diff --git a/requirements.txt b/requirements.txt
index 58437ea6..6e791585 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -9,7 +9,7 @@ cyvcf2; python_version >= '3.7'
 uvloop==0.14.0; python_version < '3.7'
 uvloop==0.16.0; python_version >= '3.7'
 aiocache==0.11.1
-ujson==4.2.0
+ujson==4.3.0
 aiomcache==0.6.0
 Authlib==0.15.5
 gunicorn==20.1.0
diff --git a/setup.py b/setup.py
index 5c08f0a1..bd1e035e 100644
--- a/setup.py
+++ b/setup.py
@@ -49,7 +49,7 @@
         "cyvcf2==0.10.1; python_version < '3.7'",
         "cyvcf2; python_version >= '3.7'",
         "aiocache==0.11.1",
-        "ujson==4.2.0",
+        "ujson==4.3.0",
         "aiomcache==0.6.0",
     ],
     extras_require={