diff --git a/requirements.txt b/requirements.txt
index 9455c56e..bc41a6c4 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -2,7 +2,7 @@ aiohttp==3.8.1
 aiohttp-cors==0.7.0
 asyncpg==0.25.0
 jsonschema==4.4.0
-Cython==0.29.27
+Cython==0.29.28
 cyvcf2==0.30.14
 uvloop==0.16.0
 aiocache==0.11.1
diff --git a/setup.py b/setup.py
index 00a08475..d9aad063 100644
--- a/setup.py
+++ b/setup.py
@@ -52,7 +52,7 @@
         "vcf": [
             "numpy==1.22.2",
             "cyvcf2==0.30.14",
-            "Cython==0.29.27",
+            "Cython==0.29.28",
         ],
         "test": [
             "coverage==6.3.2",