diff --git a/requirements.txt b/requirements.txt
index 5bad429e..892dc496 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -2,7 +2,7 @@ aiohttp==3.8.1
 aiohttp-cors==0.7.0
 asyncpg==0.25.0
 jsonschema==4.4.0
-Cython==0.29.28
+Cython==0.29.29
 cyvcf2==0.30.15
 uvloop==0.16.0
 aiocache==0.11.1
diff --git a/setup.py b/setup.py
index ee3275fe..2971bf62 100644
--- a/setup.py
+++ b/setup.py
@@ -52,7 +52,7 @@
         "vcf": [
             "numpy==1.22.3",
             "cyvcf2==0.30.15",
-            "Cython==0.29.28",
+            "Cython==0.29.29",
         ],
         "test": [
             "coverage==6.3.2",