diff --git a/requirements.txt b/requirements.txt
index 95aff06b..21c7e36f 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -3,7 +3,7 @@ aiohttp-cors==0.7.0
 asyncpg==0.26.0
 jsonschema==4.9.1
 Cython==0.29.32
-cyvcf2==0.30.15
+cyvcf2==0.30.16
 uvloop==0.16.0
 aiocache==0.11.1
 ujson==5.4.0
diff --git a/setup.py b/setup.py
index 3a62041d..2eb1dc54 100644
--- a/setup.py
+++ b/setup.py
@@ -44,14 +44,14 @@
         "jsonschema==4.9.1",
         "gunicorn==20.1.0",
         "uvloop==0.16.0",
-        "cyvcf2==0.30.15",
+        "cyvcf2==0.30.16",
         "aiocache==0.11.1",
         "ujson==5.4.0",
     ],
     extras_require={
         "vcf": [
             "numpy==1.23.2",
-            "cyvcf2==0.30.15",
+            "cyvcf2==0.30.16",
             "Cython==0.29.32",
         ],
         "test": [