diff --git a/fbcv.obo b/fbcv.obo index 6907011..c7ab006 100644 --- a/fbcv.obo +++ b/fbcv.obo @@ -1,6 +1,6 @@ format-version: 1.2 -data-version: fbcv/releases/2025-08-07 -date: 07:08:2025 16:23 +data-version: fbcv/releases/2025-10-17 +date: 17:10:2025 10:27 subsetdef: camcur "camcur" subsetdef: common_tool_use "Terms to summarize typical use of a gene from one organism that is introduced into another organism primarily for use an experimental tool, rather than to study the function of the gene" subsetdef: do_not_annotate "Term not to be used for direct annotation" @@ -13,7 +13,7 @@ idspace: terms http://purl.org/dc/terms/ ontology: fbcv.obo property_value: attributionURL "http://dx.doi.org/10.1186/2041-1480-4-30" xsd:string property_value: IAO:0000700 FBcv:0000000 -property_value: owl:versionInfo "2025-08-07" xsd:string +property_value: owl:versionInfo "2025-10-17" xsd:string property_value: terms:creator "http://orcid.org/0000-0002-1373-1705" xsd:string property_value: terms:creator "http://orcid.org/0000-0002-7073-9172" xsd:string property_value: terms:creator "https://orcid.org/0000-0001-5948-3092" xsd:string diff --git a/flybase_controlled_vocabulary.obo b/flybase_controlled_vocabulary.obo index cf6db30..7f61774 100644 --- a/flybase_controlled_vocabulary.obo +++ b/flybase_controlled_vocabulary.obo @@ -1,6 +1,6 @@ format-version: 1.2 -data-version: 2025-08-07 -date: 07:08:2025 16:23 +data-version: 2025-10-17 +date: 17:10:2025 10:28 subsetdef: camcur "camcur" subsetdef: common_tool_use "Terms to summarize typical use of a gene from one organism that is introduced into another organism primarily for use an experimental tool, rather than to study the function of the gene" subsetdef: do_not_annotate "Term not to be used for direct annotation" diff --git a/src/ontology/components/dpo-simple.owl b/src/ontology/components/dpo-simple.owl index 5643ac6..4ac0b96 100644 --- a/src/ontology/components/dpo-simple.owl +++ b/src/ontology/components/dpo-simple.owl @@ -14,7 +14,7 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + http://dx.doi.org/10.1186/2041-1480-4-30 http://orcid.org/0000-0002-1373-1705 @@ -24,9 +24,9 @@ An ontology for the description of Drosophila melanogaster phenotypes. https://creativecommons.org/licenses/by/4.0/ Drosophila Phenotype Ontology (DPO) - 07:08:2025 15:56 + 17:10:2025 10:15 FlyBase miscellaneous CV - 2025-08-07 + 2025-10-17 @@ -64,7 +64,9 @@ - + + term replaced by + @@ -418,7 +420,9 @@ - + + consider + @@ -508,13 +512,17 @@ - + + id + - + + in_subset + diff --git a/src/ontology/imports/merged_import.owl b/src/ontology/imports/merged_import.owl index a36271a..9492353 100644 --- a/src/ontology/imports/merged_import.owl +++ b/src/ontology/imports/merged_import.owl @@ -7,8 +7,8 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2025-08-07") + +Annotation(owl:versionInfo "2025-10-17") Declaration(Class()) Declaration(Class()) diff --git a/src/ontology/reports/basic-report.tsv b/src/ontology/reports/basic-report.tsv index 9807f9b..c7e775f 100644 --- a/src/ontology/reports/basic-report.tsv +++ b/src/ontology/reports/basic-report.tsv @@ -123,7 +123,7 @@ "A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." "Publication in the Spanish language." "A phenotype of a population that is the death of all animals in that population during the pharate adult stage." - "The D-enantiomer of phenylalanine." "YMDB:YMDB00995 PDBeChem:DPN ECMDB:ECMDB20144 MetaCyc:CPD-216 DrugBank:DB02556 KEGG:C02265" + "The D-enantiomer of phenylalanine." "YMDB:YMDB00995 PDBeChem:DPN MetaCyc:CPD-216 ECMDB:ECMDB20144 DrugBank:DB02556 KEGG:C02265" "Drugs that used to treat infestations by flukes (trematodes) of the genus Schistosoma." "Makes a condition worse." "Weak expression." @@ -722,7 +722,7 @@ "A stock with one or more chromosomes (balancers) that are used primarily for their ability to preserve a stock genotype without selection." "A macromolecule formed by a living organism." "Mutation caused by PM hybrid dysgenesis that is induced by the higher frequency of recombination in certain male chromosomes." - "A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone." "HMDB:HMDB0015607 Wikipedia:Lucanthone DrugBank:DB04967 KEGG:C11715" + "A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone." "KEGG:C11715 HMDB:HMDB0015607 Wikipedia:Lucanthone DrugBank:DB04967" "An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands)." "An alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum." "LINCS:LSM-6449 HMDB:HMDB0015466 DrugBank:DB01394" "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*)." @@ -1505,7 +1505,7 @@ "A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that are part of and derived from an animal with a different genotype that includes being Minute +/- and are intentionally generated in a specific tissue of the organism." "A particle smaller than an atom." "Wikipedia:Subatomic_particle" "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." - "An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia." "PPDB:1312 HMDB:HMDB0029751 MetaCyc:NAPHTHALENE KNApSAcK:C00001259 PDBeChem:NPY KEGG:C00829 Wikipedia:Naphthalene" + "An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia." "PPDB:1312 HMDB:HMDB0029751 MetaCyc:NAPHTHALENE KNApSAcK:C00001259 PDBeChem:NPY Wikipedia:Naphthalene KEGG:C00829" "Phenotype that is any abnormality in medium-term memory (GO:0072375). 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).'" "An allele that at high temperatures but not low temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." "Wikipedia:Neurotransmitter" diff --git a/src/ontology/reports/edges.tsv b/src/ontology/reports/edges.tsv index 173c4f6..7dd2e9c 100644 --- a/src/ontology/reports/edges.tsv +++ b/src/ontology/reports/edges.tsv @@ -1,721 +1,721 @@ ?x ?p ?y - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - + + + + + - - - - - - - - - + + + + + + + + + + + + + + + + + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - + + + + + + + + - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + - - - - - + + + + + + + + + + + + + + + + + + + + + + - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + - - - - - - - - - - - - + + + - - - - - - - - - - - + + + + + + + + + + + + + + + + + + - - - - - + - - - - - - - - - - - - - - + + - - + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + - + + + + + - - - - - - - - - - - - - - - - + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - + + + + - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + - - - - - - - - - - - - - - - + + + + + + + + + + + + + + - - - + - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - + + + + + - - - - - - - - - - - - - - - - - - - - - - + + + + - - - - - - - - - - - - - - - + + + + + + + + + + + - - - - - - - - - - + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - - - - - - - + + + + + + + + + + + + + + + + + - - + + + - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + - - - - - - - + + + + + + + + + + + + + + + + - - - - + + - - + + + + + + + + + + + + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + - + + + + + + + + + + + + + + + + + + + + + + - - - - - + + + + + + + + - - - - - - - - - - - - - + + + + + + + + + + + + + - - - - - - - - - - - - - - - - - + + + + + + + + + + + + - - - - - - - + + + + + + - - - - - - - - - - - - - - - - - - - - - - - + + + + - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + - - - - - - - - - - - - - + + + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + @@ -1708,12 +1708,12 @@ + - @@ -1765,9 +1765,9 @@ - + @@ -1835,10 +1835,10 @@ - + - + @@ -1889,9 +1889,9 @@ - + @@ -1928,23 +1928,23 @@ + - - + - - - + + + @@ -1963,20 +1963,20 @@ - + + + - + - - - + @@ -1993,10 +1993,10 @@ - + @@ -2026,10 +2026,10 @@ - + @@ -2076,8 +2076,8 @@ - + @@ -2091,8 +2091,8 @@ - + @@ -2105,8 +2105,8 @@ - + @@ -2115,26 +2115,26 @@ - + - + + - + - @@ -2171,20 +2171,20 @@ - + - + - + @@ -2198,8 +2198,8 @@ - + @@ -2228,10 +2228,10 @@ + - @@ -2241,9 +2241,9 @@ - + @@ -2256,8 +2256,8 @@ - + @@ -2265,10 +2265,10 @@ - - + + @@ -2280,12 +2280,12 @@ - + - + @@ -2353,8 +2353,8 @@ - + @@ -2383,8 +2383,8 @@ - + @@ -2401,9 +2401,9 @@ + - @@ -2427,9 +2427,9 @@ - + @@ -2494,9 +2494,9 @@ + - @@ -2535,8 +2535,8 @@ - + @@ -2567,8 +2567,8 @@ - + @@ -2613,8 +2613,8 @@ - + @@ -2622,8 +2622,8 @@ - + @@ -2635,18 +2635,18 @@ - + + - @@ -2685,12 +2685,12 @@ - + + - @@ -2706,11 +2706,11 @@ + - - + @@ -2749,8 +2749,8 @@ - + @@ -2768,9 +2768,9 @@ + - @@ -2784,8 +2784,8 @@ - + @@ -2797,9 +2797,9 @@ + - @@ -2808,9 +2808,9 @@ - + @@ -2851,8 +2851,8 @@ - + @@ -2870,9 +2870,9 @@ - + @@ -2889,15 +2889,15 @@ - + - + @@ -2908,13 +2908,13 @@ - + - + @@ -2927,8 +2927,8 @@ - + @@ -2951,9 +2951,9 @@ + - @@ -2977,8 +2977,8 @@ - + diff --git a/src/ontology/reports/synonyms.tsv b/src/ontology/reports/synonyms.tsv index b958dd1..cc31c63 100644 --- a/src/ontology/reports/synonyms.tsv +++ b/src/ontology/reports/synonyms.tsv @@ -118,9 +118,9 @@ "preprint" "oligo-dT priming" "DamID" - "cell cycle study" "Turkish" "obsolete ventral compartment" + "cell cycle study" "note" "group descriptor" "40-60% egg length" @@ -174,15 +174,15 @@ "obsolete Golic laboratory gene replacement kit stock" "mitochondrial protein localization tag" "physical stimulus study" + "mass spectrometry" "20-50% egg length" "distal" - "mass spectrometry" "100% egg length" "obsolete Bloomington Stock Center deficiency kit stock" "nutrition conditional" "INTACT nuclei isolation" - "0-60% egg length" "small molecule-regulated neuron activation tool" + "0-60% egg length" "high salt chromatin extraction" "project attribute" "Estonian" @@ -237,12 +237,12 @@ "p pi25.1 supplied transposase" "split nuclease" "heat sensitive hypomorphic allele - genetic evidence" - "absent" "project type" "intercalator" + "absent" "cell ablation" - "GRO-Seq" "female limited" + "GRO-Seq" "FAIRE-Seq" "80% egg length" "chemical" @@ -332,8 +332,8 @@ "caffeine" "genomic DNA isolation" "dsRNA amplicon collection" - "Ribo-Seq" "balancer descriptor" + "Ribo-Seq" "Latvian" "obsolete expressivity complete" "30-50% egg length" @@ -362,18 +362,18 @@ "expression array" "developmental stage study" "spontaneous" - "plasma membrane protein localization tag" "enhancer" + "plasma membrane protein localization tag" "uniquely mapping read alignment" - "environmental" - "construct collection" "N-nitrosodiethylamine" - "exon junction identification" + "construct collection" "Belarussian" "CRISPR/Cas9" + "environmental" "posterior" "in vitro construct" "hypermorphic allele - genetic evidence" + "exon junction identification" "intense" "ionizing radiation" "poor" @@ -497,8 +497,8 @@ "temperature conditional neomorphic allele" "small molecule-regulated RNA-guided nuclease" "driver-specific gene expression profile" - "recombinase target site" "FlyBase CV" + "recombinase target site" "blue fluorescent protein" "cell culture property" "carbohydrate mass spectrometry" @@ -579,9 +579,9 @@ "poly(A) site identification" "obsolete synthetic" "antimorphic allele - genetic evidence" + "sequence record" "granular" "epoxy hydrocarbon" - "sequence record" "obsolete In transgenic Drosophila" "cell non-autonomous" "autobiography" @@ -598,8 +598,8 @@ "deficiency screen" "Spanish" "obsolete dorsal compartment" - "metabolic pathway group" "40-100% egg length" + "metabolic pathway group" "obsolete n hr" "benzo(alpha)pyrene" "genome representation - full" @@ -619,8 +619,8 @@ "mRNA translation profile" "book review" "hexamethylphosphoramide" - "obsolete Bloomington duplication kit stock" "Affymetrix Gene Expression Array 2" + "obsolete Bloomington duplication kit stock" "origin of mutation" "surrounding" "obsolete slides" @@ -764,19 +764,19 @@ "HBL1 supplied transposase" "DNA" "neuronal activity perturbation" - "metabolite profile" "RNA tiling array" "allele descriptor" "Norwegian" "obsolete recessive visible allele recombination mapping stock" + "metabolite profile" "expression cluster" "disease qualifier" - "female" "30% egg length" - "dominance relationship qualifier" + "female" "obsolete dominant female sterile balancer" - "maternal effect" + "dominance relationship qualifier" "recessive" + "maternal effect" "obsolete stock descriptor" "60-70% egg length" "p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine" @@ -788,29 +788,29 @@ "central" "small molecule-regulated cell ablation tool" "poem" - "obsolete deficiency kit stock" "neuron inhibition tool" - "stationary phase cells" + "obsolete deficiency kit stock" "unbound RNA depletion" - "letter" + "stationary phase cells" "RNAi screen" + "letter" "Slovenian" "obsolete dorsal/ventral compartment boundary" "obsolete Vienna Drosophila RNAi Center" "MRh12 induced male recombination" "clone-based finishing" + "fly strain collection" "purification tag" "result attribute" - "fly strain collection" - "expression clustering" "obsolete in vitro construct - deletion" "obsolete extracted wild-type chromosome 1" + "expression clustering" "reagent collection type" "obsolete Whole-organism transient assay (allele of foreign species assayed in drosophilid)" "triethylenemelamine" "microtubule protein localization tag" - "gene study" "hypomorphic allele - genetic evidence" + "gene study" "thesis" "abstract" "infra-red fluorescent protein" @@ -862,8 +862,8 @@ "mated male limited" "Afrikaans" "exacerbates" - "cell clustering analysis" "obsolete ipsilateral" + "cell clustering analysis" "RPMM calculation" "single individual sample" "30-70% egg length" @@ -886,18 +886,18 @@ "Bevatron" "temperature conditional loss of function allele" "fagaronine" - "obsolete Garcia-Bellido laboratory" - "single-nucleus RNA-Seq" "temperature conditional amorphic allele - genetic evidence" - "light conditional" + "single-nucleus RNA-Seq" "temperature conditional neomorphic allele - molecular evidence" + "obsolete Garcia-Bellido laboratory" "primary cell line" "30-60% egg length" "RPKM calculation" "obsolete in vitro construct - other" - "suspension culture" "gamma ray" + "light conditional" "ICR 170" + "suspension culture" "heat sensitive antimorphic allele" "obsolete mapping stock" "split protease" @@ -937,8 +937,8 @@ "methoxy diethylnitrosamine" "binary expression system - light-regulated driver" "N-methyl-N'-nitro-N-nitrosoguanidine" - "RAMPAGE-Seq" "heat sensitive hypomorphic allele" + "RAMPAGE-Seq" "assay" "obsolete polymorphism assay" "Korean" @@ -967,8 +967,8 @@ "two hybrid screen" "binary expression system - repressor" "mononucleosomal DNA isolation" - "translated mRNA isolation" "minos activity" + "translated mRNA isolation" "hobo dysgenesis" "EMBL-EBI SCEA standard analysis method" "RNA-Seq" @@ -1015,8 +1015,8 @@ "obsolete phiC31 docking site stock" "split cell viability regulation tool" "epitope tag" - "genetic map" "mutant scorability rank" + "genetic map" "obsolete balancer for chromosome 1" "obsolete polyphasic" "subcellular component study" @@ -1058,12 +1058,12 @@ "calorie restriction conditional" "degradation tag" "random priming" - "assay material depletion" "0-70% egg length" "gene or gene product group" "40-70% egg length" - "study design" + "assay material depletion" "obsolete recessive lethal balancer for chromosome 2" + "study design" "assembly level - chromosome" "natural population" "hypermorphic allele" @@ -1111,8 +1111,8 @@ "obsolete P-element family transposable element insertions present" "biosample attribute" "biography" - "genome binding" "dorsal" + "genome binding" "obsolete recessive lethal balancer for chromosome 3" "obsolete Exelixis deficiency kit stock" "90-100% egg length" @@ -2510,8 +2510,8 @@ "Methylnitrosoharnstoff" "N-nitrosomethylurea" "N-methyl-N-nitrosocarbamide" - "NMU" "methylnitrosouree" + "NMU" "N-nitroso-N-methyluree" "Methylnitrosourea" "1-nitroso-1-methylurea" @@ -2524,9 +2524,9 @@ "2,5,-bisethylene-imine-1,4-benzoquinone" "2,5-bis(1-aziridinyl)-p-benzoquinone" "2,5-bisethyleneiminebenzoquinone" + "TW 13" "2,5-bis(aziridino)benzoquinone" "2,5-Bisaethyleniminobenzochinon-1,4" - "TW 13" "2,5-bis(1-aziridynyl)benzoquinone" "DZQ" "2,5-bis(ethyleneimino)-1,4-benzoquinone" @@ -2774,8 +2774,8 @@ "mitomycin C" "Deoxythymidine" "1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione" - "2'-deoxythymidine" "dThd" + "2'-deoxythymidine" "thymine 2'-deoxyriboside" "T" "2'-deoxy-5-methyluridine" @@ -3085,9 +3085,9 @@ "dimethylbusulfan" "2,5-hexanediol dimesylate" "1,4-dimethanesulfonoxy-1,4-dimethylbutane" + "DMM" "1,4-dimethylmyleran" "1,4-bis(methylsulfonyloxy)-1,4-dimethylbutane" - "DMM" "organosulfur heterocyclic compounds" "heterocyclic organosulfur compounds" "pnictogen molecular entities" @@ -3467,8 +3467,8 @@ "1-(2-deoxy-beta-L-ribofuranosyl)-5-methyluracil" "Beta-l-thymidine" "L-DT" - "L-thymidine" "L-deoxythymidine" + "L-thymidine" "beta-L-2'-deoxythymidine" "2'-Deoxy-L-thymidine" "organic tricyclic compounds" @@ -3763,8 +3763,8 @@ "(B(a)P)" "Benzo(a)pyrene" "3,4-Benzopyrene" - "3,4-Benzpyrene" "benzo[def]chrysene" + "3,4-Benzpyrene" "Benzpyrene" "Type I cell-death inhibitor" "Type I programmed cell-death inhibitor" @@ -4996,8 +4996,8 @@ "1728" "Aether" "1,1'-oxybisethane" - "ethyl oxide" "Anesthetic ether" + "ethyl oxide" "Diethylaether" "aether" "aether pro narcosi" @@ -5450,7 +5450,6 @@ "boron group element" "group III elements" "boron group elements" - "sodium bisulphite" "sulfurous acid sodium salt" "sulfurous acid monosodium salt" "NaHSO3" @@ -5465,6 +5464,7 @@ "sulfurous acid, monosodium salt" "sodium hydrogen sulfite" "E 222" + "sodium bisulphite" "acylamidase inhibitor" "EC 3.5.1.4 inhibitors" "acylamidase inhibitors" diff --git a/src/ontology/reports/xrefs.tsv b/src/ontology/reports/xrefs.tsv index 9f86035..9523f51 100644 --- a/src/ontology/reports/xrefs.tsv +++ b/src/ontology/reports/xrefs.tsv @@ -369,8 +369,8 @@ "MetaCyc:3-Hydroxy-Flavanones" "YMDB:YMDB00995" "PDBeChem:DPN" - "ECMDB:ECMDB20144" "MetaCyc:CPD-216" + "ECMDB:ECMDB20144" "DrugBank:DB02556" "KEGG:C02265" "Wikipedia:Adenosine_A2A_receptor" @@ -385,10 +385,10 @@ "Wikipedia:Cosmetics" "Wikipedia:Reducing_agent" "Wikipedia:Flavonoids" + "KEGG:C11715" "HMDB:HMDB0015607" "Wikipedia:Lucanthone" "DrugBank:DB04967" - "KEGG:C11715" "KEGG:C15587" "KEGG:D01038" "HMDB:HMDB0003265" @@ -461,8 +461,8 @@ "MetaCyc:NAPHTHALENE" "KNApSAcK:C00001259" "PDBeChem:NPY" - "KEGG:C00829" "Wikipedia:Naphthalene" + "KEGG:C00829" "Wikipedia:Skin_whitening" "Wikipedia:Copper(II)_sulfate" "KEGG:C18713"