diff --git a/Modules/IO/GDCM/test/Baseline/itkGDCMLegacyMultiFrameTest.mha.sha512 b/Modules/IO/GDCM/test/Baseline/itkGDCMLegacyMultiFrameTest.mha.sha512
new file mode 100644
index 00000000000..d72a7296b76
--- /dev/null
+++ b/Modules/IO/GDCM/test/Baseline/itkGDCMLegacyMultiFrameTest.mha.sha512
@@ -0,0 +1 @@
+39bdfb6ac14e79744d717a80733456dc17b23e7f8917660ded9f23f3cce50800b336f3e303ea024fc9681433c248df91b04a38cc1f9ebbfc1ead98648ed63aca
diff --git a/Modules/IO/GDCM/test/CMakeLists.txt b/Modules/IO/GDCM/test/CMakeLists.txt
index a2100b375a9..b647db28013 100644
--- a/Modules/IO/GDCM/test/CMakeLists.txt
+++ b/Modules/IO/GDCM/test/CMakeLists.txt
@@ -11,6 +11,7 @@ itkGDCMImagePositionPatientTest.cxx
 itkGDCMImageIOOrthoDirTest.cxx
 itkGDCMImageOrientationPatientTest.cxx
 itkGDCMLoadImageSpacingTest.cxx
+itkGDCMLegacyMultiFrameTest.cxx
 )
 
 CreateTestDriver(ITKIOGDCM  "${ITKIOGDCM-Test_LIBRARIES}" "${ITKIOGDCMTests}")
@@ -144,6 +145,19 @@ itk_add_test(NAME itkGDCMLoadImageNoSpacingTest
     1.0
   )
 
+itk_add_test(NAME itkGDCMLegacyMultiFrameTest
+  COMMAND ITKIOGDCMTestDriver
+    --compare ${ITK_TEST_OUTPUT_DIR}/itkGDCMLegacyMultiFrameTest.mha
+      DATA{Baseline/itkGDCMLegacyMultiFrameTest.mha}
+    itkGDCMLegacyMultiFrameTest
+      # This dataset was derived from
+      # https://www.dropbox.com/s/8m7ugu4cmw83fvd/dicoms-anon.zip?dl=0
+      # per the discussion here
+      # https://discourse.slicer.org/t/dicom-multiframe-support/4806/9
+      DATA{Input/LegacyMultiFrame.dcm}
+      ${ITK_TEST_OUTPUT_DIR}/itkGDCMLegacyMultiFrameTest.mha
+  )
+
 list(FIND ITK_WRAP_IMAGE_DIMS 2 wrap_2_index)
 if(ITK_WRAP_float AND wrap_2_index GREATER -1)
   itk_python_add_test(NAME PythonReadDicomAndReadTagTest
diff --git a/Modules/IO/GDCM/test/Input/LegacyMultiFrame.dcm.sha512 b/Modules/IO/GDCM/test/Input/LegacyMultiFrame.dcm.sha512
new file mode 100644
index 00000000000..9fb75dabda7
--- /dev/null
+++ b/Modules/IO/GDCM/test/Input/LegacyMultiFrame.dcm.sha512
@@ -0,0 +1 @@
+84d22e7b3e6df2c53eca5444d5dd113dc5d6b0f7589ee9a22667222cec99cde2d33a35eb705fbcb1b9959788eec14d7b2011312ea1270104905612698e772d2b
diff --git a/Modules/IO/GDCM/test/itkGDCMLegacyMultiFrameTest.cxx b/Modules/IO/GDCM/test/itkGDCMLegacyMultiFrameTest.cxx
new file mode 100644
index 00000000000..a6c067a8f3f
--- /dev/null
+++ b/Modules/IO/GDCM/test/itkGDCMLegacyMultiFrameTest.cxx
@@ -0,0 +1,63 @@
+/*=========================================================================
+ *
+ *  Copyright Insight Software Consortium
+ *
+ *  Licensed under the Apache License, Version 2.0 (the "License");
+ *  you may not use this file except in compliance with the License.
+ *  You may obtain a copy of the License at
+ *
+ *         http://www.apache.org/licenses/LICENSE-2.0.txt
+ *
+ *  Unless required by applicable law or agreed to in writing, software
+ *  distributed under the License is distributed on an "AS IS" BASIS,
+ *  WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ *  See the License for the specific language governing permissions and
+ *  limitations under the License.
+ *
+ *=========================================================================*/
+#include <iostream>
+#include "itkGDCMImageIO.h"
+#include "itkImageFileReader.h"
+#include "itkImageFileWriter.h"
+
+// This test verifies that we obtain the correct origin and spacing for a
+// Legacy MultiFrame DICOM file with IOD
+// LegacyConvertedEnhancedMRImageStorage.
+
+int itkGDCMLegacyMultiFrameTest(int argc, char *argv[])
+{
+  if(argc < 3)
+    {
+    std::cerr << "Usage: " << argv[0] << " <InputLegacyMultiFrameDICOM> <OutputFile>" << std::endl;
+    return EXIT_FAILURE;
+    }
+
+  const char * inputFileName = argv[1];
+  const char * outputFileName = argv[2];
+
+  using PixelType = unsigned short;
+  constexpr unsigned int Dimension = 3;
+  using ImageType = itk::Image<PixelType, Dimension>;
+
+  using ReaderType = itk::ImageFileReader<ImageType>;
+  ReaderType::Pointer reader = ReaderType::New();
+  itk::GDCMImageIO::Pointer imageIO = itk::GDCMImageIO::New();
+  reader->SetImageIO( imageIO );
+  reader->SetFileName( inputFileName );
+
+  using WriterType = itk::ImageFileWriter<ImageType>;
+  WriterType::Pointer writer = WriterType::New();
+  writer->SetInput( reader->GetOutput() );
+  writer->SetFileName( outputFileName );
+  try
+    {
+    writer->Update();
+    }
+  catch( itk::ExceptionObject & error )
+    {
+    std::cerr << "Error when running pipeline: " << error << std::endl;
+    return EXIT_FAILURE;
+    }
+
+  return EXIT_SUCCESS;
+}