diff --git a/cuda_bindings/cuda/bindings/_bindings/cydriver.pyx.in b/cuda_bindings/cuda/bindings/_bindings/cydriver.pyx.in
index 7fc86b565e..6925ff6359 100644
--- a/cuda_bindings/cuda/bindings/_bindings/cydriver.pyx.in
+++ b/cuda_bindings/cuda/bindings/_bindings/cydriver.pyx.in
@@ -490,10 +490,8 @@ cdef bint __cuPythonInit = False
 ctypedef CUresult (*__cuGetProcAddress_v2_T)(const char*, void**, int, cuuint64_t, CUdriverProcAddressQueryResult*) except?CUDA_ERROR_NOT_FOUND nogil
 cdef __cuGetProcAddress_v2_T _F_cuGetProcAddress_v2 = NULL
 
-cdef int cuPythonInit() except -1 nogil:
+cdef int _cuPythonInit() except -1 nogil:
     global __cuPythonInit
-    if __cuPythonInit:
-        return 0
 
     cdef bint usePTDS
     cdef char libPath[260]
@@ -8883,6 +8881,14 @@ cdef int cuPythonInit() except -1 nogil:
         __cuPythonInit = True
         return 0
 
+# Create a very small function to check whether we are init'ed, so the C
+# compiler can inline it.
+cdef inline int cuPythonInit() except -1 nogil:
+    if __cuPythonInit:
+        return 0
+    
+    return _cuPythonInit()
+
 {{if 'cuGetErrorString' in found_functions}}
 
 cdef CUresult _cuGetErrorString(CUresult error, const char** pStr) except ?CUDA_ERROR_NOT_FOUND nogil:
diff --git a/cuda_bindings/cuda/bindings/_bindings/cynvrtc.pyx.in b/cuda_bindings/cuda/bindings/_bindings/cynvrtc.pyx.in
index 16068f6410..44ec26ffba 100644
--- a/cuda_bindings/cuda/bindings/_bindings/cynvrtc.pyx.in
+++ b/cuda_bindings/cuda/bindings/_bindings/cynvrtc.pyx.in
@@ -40,10 +40,8 @@ cdef bint __cuPythonInit = False
 {{if 'nvrtcGetPCHHeapSizeRequired' in found_functions}}cdef void *__nvrtcGetPCHHeapSizeRequired = NULL{{endif}}
 {{if 'nvrtcSetFlowCallback' in found_functions}}cdef void *__nvrtcSetFlowCallback = NULL{{endif}}
 
-cdef int cuPythonInit() except -1 nogil:
+cdef int _cuPythonInit() except -1 nogil:
     global __cuPythonInit
-    if __cuPythonInit:
-        return 0
 
     with gil, __symbol_lock:
         {{if 'Windows' == platform.system()}}
@@ -324,6 +322,14 @@ cdef int cuPythonInit() except -1 nogil:
         __cuPythonInit = True
         return 0
 
+# Create a very small function to check whether we are init'ed, so the C
+# compiler can inline it.
+cdef inline int cuPythonInit() except -1 nogil:
+    if __cuPythonInit:
+        return 0
+
+    return _cuPythonInit()
+
 {{if 'nvrtcGetErrorString' in found_functions}}
 
 cdef const char* _nvrtcGetErrorString(nvrtcResult result) except ?NULL nogil:
diff --git a/cuda_bindings/cuda/bindings/_bindings/cyruntime.pyx.in b/cuda_bindings/cuda/bindings/_bindings/cyruntime.pyx.in
index a89dae196b..c82189fa42 100644
--- a/cuda_bindings/cuda/bindings/_bindings/cyruntime.pyx.in
+++ b/cuda_bindings/cuda/bindings/_bindings/cyruntime.pyx.in
@@ -10,16 +10,22 @@ cimport cython
 
 cdef bint __cudaPythonInit = False
 cdef bint __usePTDS = False
-cdef int cudaPythonInit() except -1 nogil:
+cdef int _cudaPythonInit() except -1 nogil:
         global __cudaPythonInit
         global __usePTDS
-        if __cudaPythonInit:
-            return __usePTDS
         with gil:
             __usePTDS = os.getenv('CUDA_PYTHON_CUDA_PER_THREAD_DEFAULT_STREAM', default=False)
         __cudaPythonInit = True
         return __usePTDS
 
+# Create a very small function to check whether we are init'ed, so the C
+# compiler can inline it.
+cdef inline int cudaPythonInit() except -1 nogil:
+    if __cudaPythonInit:
+        return __usePTDS
+
+    return _cudaPythonInit()
+
 {{if 'cudaDeviceReset' in found_functions}}
 
 cdef cudaError_t _cudaDeviceReset() except ?cudaErrorCallRequiresNewerDriver nogil:
diff --git a/cuda_bindings/docs/source/release/13.X.Y-notes.rst b/cuda_bindings/docs/source/release/13.X.Y-notes.rst
index 1ac5e42ccb..2b38504f75 100644
--- a/cuda_bindings/docs/source/release/13.X.Y-notes.rst
+++ b/cuda_bindings/docs/source/release/13.X.Y-notes.rst
@@ -14,6 +14,8 @@ Highlights
 
 * Automatic CUDA library path detection based on ``CUDA_HOME``, eliminating the need to manually set ``LIBRARY_PATH`` environment variables for installation.
 
+* The Python overhead of calling functions in CUDA bindings in `driver`, `runtime` and `nvrtc` has been reduced by approximately 30%.
+
 
 Known issues
 ------------