diff --git a/src/petab_gui/controllers/mother_controller.py b/src/petab_gui/controllers/mother_controller.py
index 3f28e43..7f9ae1e 100644
--- a/src/petab_gui/controllers/mother_controller.py
+++ b/src/petab_gui/controllers/mother_controller.py
@@ -391,6 +391,15 @@ def setup_actions(self):
         actions["redo"].triggered.connect(self.undo_stack.redo)
         actions["redo"].setEnabled(self.undo_stack.canRedo())
         self.undo_stack.canRedoChanged.connect(actions["redo"].setEnabled)
+        # Clear cells
+        actions["clear_cells"] = QAction(
+            qta.icon("mdi6.delete"),
+            "&Clear Cells", self.view
+        )
+        actions["clear_cells"].setShortcuts(
+            [QKeySequence.Delete, QKeySequence.Backspace]
+        )
+        actions["clear_cells"].triggered.connect(self.clear_cells)
         return actions
 
     def sync_visibility_with_actions(self):
@@ -768,6 +777,11 @@ def delete_column(self):
         if controller:
             controller.delete_column()
 
+    def clear_cells(self):
+        controller = self.active_controller()
+        if controller:
+            controller.clear_cells()
+
     def filter_table(self):
         """Filter the currently activated tables"""
         filter_text = self.filter_input.text()
diff --git a/src/petab_gui/controllers/table_controllers.py b/src/petab_gui/controllers/table_controllers.py
index 7e6e964..c3f8a27 100644
--- a/src/petab_gui/controllers/table_controllers.py
+++ b/src/petab_gui/controllers/table_controllers.py
@@ -13,7 +13,7 @@
     ColumnSuggestionDelegate, ComboBoxDelegate, ParameterIdSuggestionDelegate
 from ..utils import get_selected, process_file, ConditionInputDialog
 from .utils import prompt_overwrite_or_append, linter_wrapper
-from ..C import COLUMN
+from ..C import COLUMN, INDEX
 import re
 
 
@@ -286,6 +286,11 @@ def add_column(self, column_name: str = None):
                 return
         self.model.insertColumn(column_name)
 
+    def clear_cells(self):
+        """Clear all selected cells"""
+        selected = get_selected(self.view.table_view, mode=INDEX)
+        self.model.clear_cells(selected)
+
     def set_index_on_new_row(self, index: QModelIndex):
         """Set the index of the model when a new row is added."""
         proxy_index = self.proxy_model.mapFromSource(index)
diff --git a/src/petab_gui/models/pandas_table_model.py b/src/petab_gui/models/pandas_table_model.py
index 76acfea..83e1de4 100644
--- a/src/petab_gui/models/pandas_table_model.py
+++ b/src/petab_gui/models/pandas_table_model.py
@@ -148,7 +148,9 @@ def insertColumn(self, column_name: str):
 
         return True
 
-    def setData(self, index, value, role=Qt.EditRole):
+    def setData(
+        self, index, value, role=Qt.EditRole, check_multi: bool = True
+    ):
         if not (index.isValid() and role == Qt.EditRole):
             return False
 
@@ -157,8 +159,10 @@ def setData(self, index, value, role=Qt.EditRole):
 
         if is_invalid(value) or value == "":
             value = None
-        # check whether multiple rows but only one column is selected
-        multi_row_change, selected = self.check_selection()
+        multi_row_change = False
+        if check_multi:
+            # check whether multiple rows but only one column is selected
+            multi_row_change, selected = self.check_selection()
         if not multi_row_change:
             self.undo_stack.beginMacro("Set data")
             success = self._set_data_single(index, value)
@@ -250,6 +254,14 @@ def _push_change_and_notify(
                               [Qt.DisplayRole])
         self.something_changed.emit(True)
 
+    def clear_cells(self, selected):
+        """Clear the selected cells."""
+        self.undo_stack.beginMacro("Clear cells")
+        for index in selected:
+            if index.isValid():
+                self.setData(index, None, Qt.EditRole, False)
+        self.undo_stack.endMacro()
+
     def handle_named_index(self, index, value):
         """Handle the named index column."""
         pass