diff --git a/docs/source/losses.rst b/docs/source/losses.rst
index a6aa4d566d..5e19219fee 100644
--- a/docs/source/losses.rst
+++ b/docs/source/losses.rst
@@ -74,4 +74,12 @@ Registration Losses
 `GlobalMutualInformationLoss`
 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
 .. autoclass:: GlobalMutualInformationLoss
+    :members:
+
+Loss Wrappers
+--------------
+
+`MultiScaleLoss`
+~~~~~~~~~~~~~~~~~
+.. autoclass:: MultiScaleLoss
     :members:
\ No newline at end of file
diff --git a/monai/losses/__init__.py b/monai/losses/__init__.py
index 591fb08f7b..b9146a6962 100644
--- a/monai/losses/__init__.py
+++ b/monai/losses/__init__.py
@@ -23,4 +23,5 @@
 )
 from .focal_loss import FocalLoss
 from .image_dissimilarity import GlobalMutualInformationLoss, LocalNormalizedCrossCorrelationLoss
+from .multi_scale import MultiScaleLoss
 from .tversky import TverskyLoss
diff --git a/monai/losses/multi_scale.py b/monai/losses/multi_scale.py
new file mode 100644
index 0000000000..5a17bc2d07
--- /dev/null
+++ b/monai/losses/multi_scale.py
@@ -0,0 +1,100 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from typing import List, Optional, Union
+
+import torch
+from torch.nn.modules.loss import _Loss
+
+from monai.networks.layers import gaussian_1d, separable_filtering
+from monai.utils import LossReduction
+
+
+def make_gaussian_kernel(sigma: int) -> torch.Tensor:
+    if sigma <= 0:
+        raise ValueError(f"expecting positive sigma, got sigma={sigma}")
+    kernel = gaussian_1d(sigma=torch.tensor(sigma), truncated=3, approx="sampled", normalize=False)
+    return kernel
+
+
+def make_cauchy_kernel(sigma: int) -> torch.Tensor:
+    if sigma <= 0:
+        raise ValueError(f"expecting positive sigma, got sigma={sigma}")
+    tail = int(sigma * 5)
+    k = torch.tensor([((x / sigma) ** 2 + 1) for x in range(-tail, tail + 1)])
+    k = torch.reciprocal(k)
+    k = k / torch.sum(k)
+    return k
+
+
+kernel_fn_dict = {
+    "gaussian": make_gaussian_kernel,
+    "cauchy": make_cauchy_kernel,
+}
+
+
+class MultiScaleLoss(_Loss):
+    """
+    This is a wrapper class.
+    It smooths the input and target at different scales before passing them into the wrapped loss function.
+
+    Adapted from:
+        DeepReg (https://github.com/DeepRegNet/DeepReg)
+    """
+
+    def __init__(
+        self,
+        loss: _Loss,
+        scales: Optional[List] = None,
+        kernel: str = "gaussian",
+        reduction: Union[LossReduction, str] = LossReduction.MEAN,
+    ) -> None:
+        """
+        Args:
+            loss: loss function to be wrapped
+            scales: list of scalars or None, if None, do not apply any scaling.
+            kernel: gaussian or cauchy.
+        """
+        super(MultiScaleLoss, self).__init__(reduction=LossReduction(reduction).value)
+        if kernel not in kernel_fn_dict.keys():
+            raise ValueError(f"got unsupported kernel type: {kernel}", "only support gaussian and cauchy")
+        self.kernel_fn = kernel_fn_dict[kernel]
+        self.loss = loss
+        self.scales = scales
+
+    def forward(self, y_true: torch.Tensor, y_pred: torch.Tensor) -> torch.Tensor:
+        if self.scales is None:
+            loss: torch.Tensor = self.loss(y_pred, y_true)
+        else:
+            loss_list = []
+            for s in self.scales:
+                if s == 0:
+                    # no smoothing
+                    loss_list.append(self.loss(y_pred, y_true))
+                else:
+                    loss_list.append(
+                        self.loss(
+                            separable_filtering(y_pred, [self.kernel_fn(s)] * (y_true.ndim - 2)),
+                            separable_filtering(y_true, [self.kernel_fn(s)] * (y_true.ndim - 2)),
+                        )
+                    )
+            loss = torch.stack(loss_list, dim=0)
+
+        if self.reduction == LossReduction.MEAN.value:
+            loss = torch.mean(loss)  # the batch and channel average
+        elif self.reduction == LossReduction.SUM.value:
+            loss = torch.sum(loss)  # sum over the batch and channel dims
+        elif self.reduction == LossReduction.NONE.value:
+            pass  # returns [N, n_classes] losses
+        else:
+            raise ValueError(f'Unsupported reduction: {self.reduction}, available options are ["mean", "sum", "none"].')
+
+        return loss
diff --git a/tests/test_multi_scale.py b/tests/test_multi_scale.py
new file mode 100644
index 0000000000..722ae7cfce
--- /dev/null
+++ b/tests/test_multi_scale.py
@@ -0,0 +1,60 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+import unittest
+
+import numpy as np
+import torch
+from parameterized import parameterized
+
+from monai.losses import DiceLoss
+from monai.losses.multi_scale import MultiScaleLoss
+
+dice_loss = DiceLoss(include_background=True, sigmoid=True, smooth_nr=1e-5, smooth_dr=1e-5)
+
+TEST_CASES = [
+    [
+        {"loss": dice_loss, "scales": None, "kernel": "gaussian"},
+        {"y_pred": torch.tensor([[[[1.0, -1.0], [-1.0, 1.0]]]]), "y_true": torch.tensor([[[[1.0, 0.0], [1.0, 1.0]]]])},
+        0.307576,
+    ],
+    [
+        {"loss": dice_loss, "scales": [0, 1], "kernel": "gaussian"},
+        {"y_pred": torch.tensor([[[[1.0, -1.0], [-1.0, 1.0]]]]), "y_true": torch.tensor([[[[1.0, 0.0], [1.0, 1.0]]]])},
+        0.463116,
+    ],
+    [
+        {"loss": dice_loss, "scales": [0, 1, 2], "kernel": "cauchy"},
+        {
+            "y_pred": torch.tensor([[[[[1.0, -1.0], [-1.0, 1.0]]]]]),
+            "y_true": torch.tensor([[[[[1.0, 0.0], [1.0, 1.0]]]]]),
+        },
+        0.715228,
+    ],
+]
+
+
+class TestMultiScale(unittest.TestCase):
+    @parameterized.expand(TEST_CASES)
+    def test_shape(self, input_param, input_data, expected_val):
+        result = MultiScaleLoss(**input_param).forward(**input_data)
+        np.testing.assert_allclose(result.detach().cpu().numpy(), expected_val, rtol=1e-5)
+
+    def test_ill_opts(self):
+        with self.assertRaisesRegex(ValueError, ""):
+            MultiScaleLoss(loss=dice_loss, kernel="none")
+        with self.assertRaisesRegex(ValueError, ""):
+            MultiScaleLoss(loss=dice_loss, scales=[-1])(torch.ones((1, 1, 3)), torch.ones((1, 1, 3)))
+        with self.assertRaisesRegex(ValueError, ""):
+            MultiScaleLoss(loss=dice_loss, scales=[-1], reduction="none")(torch.ones((1, 1, 3)), torch.ones((1, 1, 3)))
+
+
+if __name__ == "__main__":
+    unittest.main()