diff --git a/docs/source/handlers.rst b/docs/source/handlers.rst
index 080e7e138c..869467c496 100644
--- a/docs/source/handlers.rst
+++ b/docs/source/handlers.rst
@@ -115,3 +115,8 @@ EarlyStop handler
 -----------------
 .. autoclass:: EarlyStopHandler
     :members:
+
+GarbageCollector handler
+------------------------
+.. autoclass:: GarbageCollector
+    :members:
diff --git a/monai/handlers/__init__.py b/monai/handlers/__init__.py
index a1f86310ae..2112b074a0 100644
--- a/monai/handlers/__init__.py
+++ b/monai/handlers/__init__.py
@@ -14,6 +14,7 @@
 from .classification_saver import ClassificationSaver
 from .confusion_matrix import ConfusionMatrix
 from .earlystop_handler import EarlyStopHandler
+from .garbage_collector import GarbageCollector
 from .hausdorff_distance import HausdorffDistance
 from .iteration_metric import IterationMetric
 from .lr_schedule_handler import LrScheduleHandler
diff --git a/monai/handlers/garbage_collector.py b/monai/handlers/garbage_collector.py
new file mode 100644
index 0000000000..7bb59c9049
--- /dev/null
+++ b/monai/handlers/garbage_collector.py
@@ -0,0 +1,80 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import gc
+from typing import TYPE_CHECKING
+
+from monai.utils import exact_version, optional_import
+
+if TYPE_CHECKING:
+    from ignite.engine import Engine, Events
+else:
+    Engine, _ = optional_import("ignite.engine", "0.4.4", exact_version, "Engine")
+    Events, _ = optional_import("ignite.engine", "0.4.4", exact_version, "Events")
+
+
+class GarbageCollector:
+    """
+    Run garbage collector after each epoch
+
+    Args:
+        trigger_event: the event that trigger a call to this handler.
+            - "epoch", after completion of each epoch (equivalent of ignite.engine.Events.EPOCH_COMPLETED)
+            - "iteration", after completion of each iteration (equivalent of ignite.engine.Events.ITERATION_COMPLETED)
+            - any ignite built-in event from ignite.engine.Events.
+            Defaults to "epoch".
+        log_level: log level (integer) for some garbage collection information as below. Defaults to 10 (DEBUG).
+            - 50 (CRITICAL)
+            - 40 (ERROR)
+            - 30 (WARNING)
+            - 20 (INFO)
+            - 10 (DEBUG)
+            - 0 (NOTSET)
+    """
+
+    def __init__(self, trigger_event: str = "epoch", log_level: int = 10):
+        if isinstance(trigger_event, Events):
+            self.trigger_event = trigger_event
+        elif trigger_event.lower() == "epoch":
+            self.trigger_event = Events.EPOCH_COMPLETED
+        elif trigger_event.lower() == "iteration":
+            self.trigger_event = Events.ITERATION_COMPLETED
+        else:
+            raise ValueError(
+                f"'trigger_event' should be either epoch, iteration, or an ignite built-in event from"
+                f" ignite.engine.Events, '{trigger_event}' was given."
+            )
+
+        self.log_level = log_level
+
+    def attach(self, engine: Engine) -> None:
+        if not engine.has_event_handler(self, self.trigger_event):
+            engine.add_event_handler(self.trigger_event, self)
+
+    def __call__(self, engine: Engine) -> None:
+        """
+        This method calls python garbage collector.
+
+        Args:
+            engine: Ignite Engine, it should be either a trainer or validator.
+        """
+        # get count before garbage collection
+        pre_count = gc.get_count()
+        # fits call to garbage collector
+        gc.collect()
+        # second call to garbage collector
+        unreachable = gc.collect()
+        # get count after garbage collection
+        after_count = gc.get_count()
+        engine.logger.log(
+            self.log_level,
+            f"Garbage Count: [before: {pre_count}] -> [after: {after_count}] (unreachable : {unreachable})",
+        )
diff --git a/tests/min_tests.py b/tests/min_tests.py
index 4433081c46..9b96e7eaab 100644
--- a/tests/min_tests.py
+++ b/tests/min_tests.py
@@ -42,6 +42,7 @@ def run_testsuit():
         "test_handler_confusion_matrix",
         "test_handler_confusion_matrix_dist",
         "test_handler_hausdorff_distance",
+        "test_handler_garbage_collector",
         "test_handler_mean_dice",
         "test_handler_prob_map_producer",
         "test_handler_rocauc",
diff --git a/tests/test_handler_garbage_collector.py b/tests/test_handler_garbage_collector.py
new file mode 100644
index 0000000000..5e6bd7275c
--- /dev/null
+++ b/tests/test_handler_garbage_collector.py
@@ -0,0 +1,77 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import gc
+import unittest
+from unittest import skipUnless
+
+import torch
+from ignite.engine import Engine
+from parameterized import parameterized
+
+from monai.data import Dataset
+from monai.handlers import GarbageCollector
+from monai.utils import exact_version, optional_import
+
+Events, has_ignite = optional_import("ignite.engine", "0.4.4", exact_version, "Events")
+
+
+TEST_CASE_0 = [[0, 1, 2], "epoch"]
+
+TEST_CASE_1 = [[0, 1, 2], "iteration"]
+
+TEST_CASE_2 = [[0, 1, 2], Events.EPOCH_COMPLETED]
+
+
+class TestHandlerGarbageCollector(unittest.TestCase):
+    @skipUnless(has_ignite, "Requires ignite")
+    @parameterized.expand(
+        [
+            TEST_CASE_0,
+            TEST_CASE_1,
+            TEST_CASE_2,
+        ]
+    )
+    def test_content(self, data, trigger_event):
+        # set up engine
+        gb_count_dict = {}
+
+        def _train_func(engine, batch):
+            # store garbage collection counts
+            if trigger_event == Events.EPOCH_COMPLETED or trigger_event.lower() == "epoch":
+                if engine.state.iteration % engine.state.epoch_length == 1:
+                    gb_count_dict[engine.state.epoch] = gc.get_count()
+            elif trigger_event.lower() == "iteration":
+                gb_count_dict[engine.state.iteration] = gc.get_count()
+
+        engine = Engine(_train_func)
+
+        # set up testing handler
+        dataset = Dataset(data, transform=None)
+        data_loader = torch.utils.data.DataLoader(dataset, batch_size=1)
+        GarbageCollector(trigger_event=trigger_event, log_level=30).attach(engine)
+
+        engine.run(data_loader, max_epochs=5)
+        print(gb_count_dict)
+
+        first_count = 0
+        for epoch, gb_count in gb_count_dict.items():
+            # At least one zero-generation object
+            self.assertGreater(gb_count[0], 0)
+            if epoch == 1:
+                first_count = gb_count[0]
+            else:
+                # The should be less number of collected objects in the next calls.
+                self.assertLess(gb_count[0], first_count)
+
+
+if __name__ == "__main__":
+    unittest.main()