diff --git a/monai/apps/deepedit/__init__.py b/monai/apps/deepedit/__init__.py
new file mode 100644
index 0000000000..14ae193634
--- /dev/null
+++ b/monai/apps/deepedit/__init__.py
@@ -0,0 +1,10 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
diff --git a/monai/apps/deepedit/transforms.py b/monai/apps/deepedit/transforms.py
new file mode 100644
index 0000000000..2ab2722076
--- /dev/null
+++ b/monai/apps/deepedit/transforms.py
@@ -0,0 +1,167 @@
+import json
+import logging
+from typing import Dict, Hashable, Mapping, Tuple
+
+import numpy as np
+
+from monai.config import KeysCollection
+from monai.transforms.transform import MapTransform, Randomizable, Transform
+
+logger = logging.getLogger(__name__)
+
+from monai.utils import optional_import
+
+distance_transform_cdt, _ = optional_import("scipy.ndimage.morphology", name="distance_transform_cdt")
+
+
+class DiscardAddGuidanced(MapTransform):
+    def __init__(
+        self,
+        keys: KeysCollection,
+        probability: float = 1.0,
+        allow_missing_keys: bool = False,
+    ):
+        """
+        Discard positive and negative points randomly or Add the two channels for inference time
+
+        :param probability: Discard probability; For inference it will be always 1.0
+        """
+        super().__init__(keys, allow_missing_keys)
+        self.probability = probability
+
+    def _apply(self, image):
+        if self.probability >= 1.0 or np.random.choice([True, False], p=[self.probability, 1 - self.probability]):
+            signal = np.zeros((1, image.shape[-3], image.shape[-2], image.shape[-1]), dtype=np.float32)
+            if image.shape[0] == 3:
+                image[1] = signal
+                image[2] = signal
+            else:
+                image = np.concatenate((image, signal, signal), axis=0)
+        return image
+
+    def __call__(self, data: Mapping[Hashable, np.ndarray]) -> Dict[Hashable, np.ndarray]:
+        d: Dict = dict(data)
+        for key in self.key_iterator(d):
+            if key == "image":
+                d[key] = self._apply(d[key])
+            else:
+                print("This transform only applies to the image")
+        return d
+
+
+class ResizeGuidanceCustomd(Transform):
+    """
+    Resize the guidance based on cropped vs resized image.
+    """
+
+    def __init__(
+        self,
+        guidance: str,
+        ref_image: str,
+    ) -> None:
+        self.guidance = guidance
+        self.ref_image = ref_image
+
+    def __call__(self, data):
+        d = dict(data)
+        current_shape = d[self.ref_image].shape[1:]
+
+        factor = np.divide(current_shape, d["image_meta_dict"]["dim"][1:4])
+        pos_clicks, neg_clicks = d["foreground"], d["background"]
+
+        pos = np.multiply(pos_clicks, factor).astype(int).tolist() if len(pos_clicks) else []
+        neg = np.multiply(neg_clicks, factor).astype(int).tolist() if len(neg_clicks) else []
+
+        d[self.guidance] = [pos, neg]
+        return d
+
+
+class ClickRatioAddRandomGuidanced(Randomizable, Transform):
+    """
+    Add random guidance based on discrepancies that were found between label and prediction.
+    Args:
+        guidance: key to guidance source, shape (2, N, # of dim)
+        discrepancy: key that represents discrepancies found between label and prediction, shape (2, C, D, H, W) or (2, C, H, W)
+        probability: key that represents click/interaction probability, shape (1)
+        fn_fp_click_ratio: ratio of clicks between FN and FP
+    """
+
+    def __init__(
+        self,
+        guidance: str = "guidance",
+        discrepancy: str = "discrepancy",
+        probability: str = "probability",
+        fn_fp_click_ratio: Tuple[float, float] = (1.0, 1.0),
+    ):
+        self.guidance = guidance
+        self.discrepancy = discrepancy
+        self.probability = probability
+        self.fn_fp_click_ratio = fn_fp_click_ratio
+        self._will_interact = None
+
+    def randomize(self, data=None):
+        probability = data[self.probability]
+        self._will_interact = self.R.choice([True, False], p=[probability, 1.0 - probability])
+
+    def find_guidance(self, discrepancy):
+        distance = distance_transform_cdt(discrepancy).flatten()
+        probability = np.exp(distance) - 1.0
+        idx = np.where(discrepancy.flatten() > 0)[0]
+
+        if np.sum(discrepancy > 0) > 0:
+            seed = self.R.choice(idx, size=1, p=probability[idx] / np.sum(probability[idx]))
+            dst = distance[seed]
+
+            g = np.asarray(np.unravel_index(seed, discrepancy.shape)).transpose().tolist()[0]
+            g[0] = dst[0]
+            return g
+        return None
+
+    def add_guidance(self, discrepancy, will_interact):
+        if not will_interact:
+            return None, None
+
+        pos_discr = discrepancy[0]
+        neg_discr = discrepancy[1]
+
+        can_be_positive = np.sum(pos_discr) > 0
+        can_be_negative = np.sum(neg_discr) > 0
+
+        pos_prob = self.fn_fp_click_ratio[0] / (self.fn_fp_click_ratio[0] + self.fn_fp_click_ratio[1])
+        neg_prob = self.fn_fp_click_ratio[1] / (self.fn_fp_click_ratio[0] + self.fn_fp_click_ratio[1])
+
+        correct_pos = self.R.choice([True, False], p=[pos_prob, neg_prob])
+
+        if can_be_positive and not can_be_negative:
+            return self.find_guidance(pos_discr), None
+
+        if not can_be_positive and can_be_negative:
+            return None, self.find_guidance(neg_discr)
+
+        if correct_pos and can_be_positive:
+            return self.find_guidance(pos_discr), None
+
+        if not correct_pos and can_be_negative:
+            return None, self.find_guidance(neg_discr)
+        return None, None
+
+    def _apply(self, guidance, discrepancy):
+        guidance = guidance.tolist() if isinstance(guidance, np.ndarray) else guidance
+        guidance = json.loads(guidance) if isinstance(guidance, str) else guidance
+        pos, neg = self.add_guidance(discrepancy, self._will_interact)
+        if pos:
+            guidance[0].append(pos)
+            guidance[1].append([-1] * len(pos))
+        if neg:
+            guidance[0].append([-1] * len(neg))
+            guidance[1].append(neg)
+
+        return json.dumps(np.asarray(guidance).astype(int).tolist())
+
+    def __call__(self, data):
+        d = dict(data)
+        guidance = d[self.guidance]
+        discrepancy = d[self.discrepancy]
+        self.randomize(data)
+        d[self.guidance] = self._apply(guidance, discrepancy)
+        return d
diff --git a/tests/min_tests.py b/tests/min_tests.py
index d2f8f0aff6..5b376d7b57 100644
--- a/tests/min_tests.py
+++ b/tests/min_tests.py
@@ -37,6 +37,7 @@ def run_testsuit():
         "test_csv_iterable_dataset",
         "test_dataset",
         "test_dataset_summary",
+        "test_deepedit_transforms",
         "test_deepgrow_dataset",
         "test_deepgrow_interaction",
         "test_deepgrow_transforms",
diff --git a/tests/test_deepedit_transforms.py b/tests/test_deepedit_transforms.py
new file mode 100644
index 0000000000..c2b11e8ee7
--- /dev/null
+++ b/tests/test_deepedit_transforms.py
@@ -0,0 +1,97 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+import numpy as np
+from parameterized import parameterized
+
+from monai.apps.deepedit.transforms import ClickRatioAddRandomGuidanced, DiscardAddGuidanced, ResizeGuidanceCustomd
+
+IMAGE = np.array([[[[1, 0, 2, 0, 1], [0, 1, 2, 1, 0], [2, 2, 3, 2, 2], [0, 1, 2, 1, 0], [1, 0, 2, 0, 1]]]])
+LABEL = np.array([[[[0, 0, 0, 0, 0], [0, 1, 0, 1, 0], [0, 0, 1, 0, 0], [0, 1, 0, 1, 0], [0, 0, 0, 0, 0]]]])
+
+DATA_1 = {
+    "image": IMAGE,
+    "label": LABEL,
+    "image_meta_dict": {"dim": IMAGE.shape},
+    "label_meta_dict": {},
+    "foreground": [0, 0, 0],
+    "background": [0, 0, 0],
+}
+
+DISCARD_ADD_GUIDANCE_TEST_CASE = [
+    {"image": IMAGE, "label": LABEL},
+    DATA_1,
+    (3, 1, 5, 5),
+]
+
+DATA_2 = {
+    "image": IMAGE,
+    "label": LABEL,
+    "guidance": np.array([[[1, 0, 2, 2]], [[-1, -1, -1, -1]]]),
+    "discrepancy": np.array(
+        [
+            [[[[0, 0, 0, 0, 0], [0, 0, 0, 1, 0], [0, 0, 0, 0, 0], [0, 0, 0, 0, 0], [0, 0, 0, 0, 0]]]],
+            [[[[0, 0, 0, 0, 0], [0, 0, 0, 0, 0], [0, 1, 0, 0, 0], [0, 0, 0, 0, 0], [0, 0, 0, 0, 0]]]],
+        ]
+    ),
+    "probability": 1.0,
+}
+
+CLICK_RATIO_ADD_RANDOM_GUIDANCE_TEST_CASE_1 = [
+    {"guidance": "guidance", "discrepancy": "discrepancy", "probability": "probability"},
+    DATA_2,
+    "[[[1, 0, 2, 2], [-1, -1, -1, -1]], [[-1, -1, -1, -1], [1, 0, 2, 1]]]",
+]
+
+DATA_3 = {
+    "image": np.arange(1000).reshape((1, 5, 10, 20)),
+    "image_meta_dict": {"foreground_cropped_shape": (1, 10, 20, 40), "dim": [3, 512, 512, 128]},
+    "guidance": [[[6, 10, 14], [8, 10, 14]], [[8, 10, 16]]],
+    "foreground": [[10, 14, 6], [10, 14, 8]],
+    "background": [[10, 16, 8]],
+}
+
+RESIZE_GUIDANCE_TEST_CASE_1 = [
+    {"ref_image": "image", "guidance": "guidance"},
+    DATA_3,
+    [[[0, 0, 0], [0, 0, 1]], [[0, 0, 1]]],
+]
+
+
+class TestDiscardAddGuidanced(unittest.TestCase):
+    @parameterized.expand([DISCARD_ADD_GUIDANCE_TEST_CASE])
+    def test_correct_results(self, arguments, input_data, expected_result):
+        add_fn = DiscardAddGuidanced(arguments)
+        result = add_fn(input_data)
+        self.assertEqual(result["image"].shape, expected_result)
+
+
+class TestClickRatioAddRandomGuidanced(unittest.TestCase):
+    @parameterized.expand([CLICK_RATIO_ADD_RANDOM_GUIDANCE_TEST_CASE_1])
+    def test_correct_results(self, arguments, input_data, expected_result):
+        seed = 0
+        add_fn = ClickRatioAddRandomGuidanced(**arguments)
+        add_fn.set_random_state(seed)
+        result = add_fn(input_data)
+        self.assertEqual(result[arguments["guidance"]], expected_result)
+
+
+class TestResizeGuidanced(unittest.TestCase):
+    @parameterized.expand([RESIZE_GUIDANCE_TEST_CASE_1])
+    def test_correct_results(self, arguments, input_data, expected_result):
+        result = ResizeGuidanceCustomd(**arguments)(input_data)
+        self.assertEqual(result[arguments["guidance"]], expected_result)
+
+
+if __name__ == "__main__":
+    unittest.main()