diff --git a/monai/data/dataset.py b/monai/data/dataset.py
index c970e83d0d..2549041fbd 100644
--- a/monai/data/dataset.py
+++ b/monai/data/dataset.py
@@ -575,6 +575,7 @@ def __init__(
         cache_rate: float = 1.0,
         num_workers: Optional[int] = None,
         progress: bool = True,
+        copy_cache: bool = True,
     ) -> None:
         """
         Args:
@@ -587,11 +588,16 @@ def __init__(
             num_workers: the number of worker processes to use.
                 If num_workers is None then the number returned by os.cpu_count() is used.
             progress: whether to display a progress bar.
+            copy_cache: whether to `deepcopy` the cache content before applying the random transforms,
+                default to `True`. if the random transforms don't modify the cache content
+                or every cache item is only used once in a `multi-processing` environment,
+                may set `copy=False` for better performance.
         """
         if not isinstance(transform, Compose):
             transform = Compose(transform)
         super().__init__(data=data, transform=transform)
         self.progress = progress
+        self.copy_cache = copy_cache
         self.cache_num = min(int(cache_num), int(len(data) * cache_rate), len(data))
         self.num_workers = num_workers
         if self.num_workers is not None:
@@ -656,7 +662,8 @@ def _transform(self, index: int):
                 # only need to deep copy data on first non-deterministic transform
                 if not start_run:
                     start_run = True
-                    data = deepcopy(data)
+                    if self.copy_cache:
+                        data = deepcopy(data)
                 data = apply_transform(_transform, data)
         return data
 
@@ -722,6 +729,10 @@ class SmartCacheDataset(Randomizable, CacheDataset):
         shuffle: whether to shuffle the whole data list before preparing the cache content for first epoch.
             it will not modify the original input data sequence in-place.
         seed: random seed if shuffle is `True`, default to `0`.
+        copy_cache: whether to `deepcopy` the cache content before applying the random transforms,
+            default to `True`. if the random transforms don't modify the cache content
+            or every cache item is only used once in a `multi-processing` environment,
+            may set `copy=False` for better performance.
     """
 
     def __init__(
@@ -736,6 +747,7 @@ def __init__(
         progress: bool = True,
         shuffle: bool = True,
         seed: int = 0,
+        copy_cache: bool = True,
     ) -> None:
         if shuffle:
             self.set_random_state(seed=seed)
@@ -743,7 +755,7 @@ def __init__(
             self.randomize(data)
         self.shuffle = shuffle
 
-        super().__init__(data, transform, cache_num, cache_rate, num_init_workers, progress)
+        super().__init__(data, transform, cache_num, cache_rate, num_init_workers, progress, copy_cache)
         if self._cache is None:
             self._cache = self._fill_cache()
         if self.cache_num >= len(data):
diff --git a/tests/test_cachedataset.py b/tests/test_cachedataset.py
index bbb8143631..e5bb1b9a90 100644
--- a/tests/test_cachedataset.py
+++ b/tests/test_cachedataset.py
@@ -19,7 +19,7 @@
 from parameterized import parameterized
 
 from monai.data import CacheDataset, DataLoader, PersistentDataset, SmartCacheDataset
-from monai.transforms import Compose, Lambda, LoadImaged, ThreadUnsafe, Transform
+from monai.transforms import Compose, Lambda, LoadImaged, RandLambda, ThreadUnsafe, Transform
 from monai.utils import get_torch_version_tuple
 
 TEST_CASE_1 = [Compose([LoadImaged(keys=["image", "label", "extra"])]), (128, 128, 128)]
@@ -84,7 +84,12 @@ def test_shape(self, transform, expected_shape):
     def test_set_data(self):
         data_list1 = list(range(10))
 
-        transform = Lambda(func=lambda x: np.array([x * 10]))
+        transform = Compose(
+            [
+                Lambda(func=lambda x: np.array([x * 10])),
+                RandLambda(func=lambda x: x + 1),
+            ]
+        )
 
         dataset = CacheDataset(
             data=data_list1,
@@ -92,19 +97,23 @@ def test_set_data(self):
             cache_rate=1.0,
             num_workers=4,
             progress=True,
+            copy_cache=False if sys.platform == "linux" else True,
         )
 
         num_workers = 2 if sys.platform == "linux" else 0
         dataloader = DataLoader(dataset=dataset, num_workers=num_workers, batch_size=1)
         for i, d in enumerate(dataloader):
-            np.testing.assert_allclose([[data_list1[i] * 10]], d)
+            np.testing.assert_allclose([[data_list1[i] * 10 + 1]], d)
+        # simulate another epoch, the cache content should not be modified
+        for i, d in enumerate(dataloader):
+            np.testing.assert_allclose([[data_list1[i] * 10 + 1]], d)
 
         # update the datalist and fill the cache content
         data_list2 = list(range(-10, 0))
         dataset.set_data(data=data_list2)
         # rerun with updated cache content
         for i, d in enumerate(dataloader):
-            np.testing.assert_allclose([[data_list2[i] * 10]], d)
+            np.testing.assert_allclose([[data_list2[i] * 10 + 1]], d)
 
 
 class _StatefulTransform(Transform, ThreadUnsafe):