diff --git a/docs/source/networks.rst b/docs/source/networks.rst
index 39889266d9..452df4580d 100644
--- a/docs/source/networks.rst
+++ b/docs/source/networks.rst
@@ -188,6 +188,26 @@ Blocks
 .. autoclass:: PatchEmbeddingBlock
     :members:
 
+`FactorizedIncreaseBlock`
+~~~~~~~~~~~~~~~~~~~~~~~~~
+.. autoclass:: FactorizedIncreaseBlock
+    :members:
+
+`FactorizedReduceBlock`
+~~~~~~~~~~~~~~~~~~~~~~~
+.. autoclass:: FactorizedReduceBlock
+    :members:
+
+`P3DActiConvNormBlock`
+~~~~~~~~~~~~~~~~~~~~~~
+.. autoclass:: P3DActiConvNormBlock
+    :members:
+
+`ActiConvNormBlock`
+~~~~~~~~~~~~~~~~~~~
+.. autoclass:: ActiConvNormBlock
+    :members:
+
 `Warp`
 ~~~~~~
 .. autoclass:: Warp
diff --git a/monai/networks/blocks/__init__.py b/monai/networks/blocks/__init__.py
index db723f622d..01a5bfca2a 100644
--- a/monai/networks/blocks/__init__.py
+++ b/monai/networks/blocks/__init__.py
@@ -14,6 +14,7 @@
 from .aspp import SimpleASPP
 from .convolutions import Convolution, ResidualUnit
 from .crf import CRF
+from .dints_block import ActiConvNormBlock, FactorizedIncreaseBlock, FactorizedReduceBlock, P3DActiConvNormBlock
 from .downsample import MaxAvgPool
 from .dynunet_block import UnetBasicBlock, UnetOutBlock, UnetResBlock, UnetUpBlock, get_output_padding, get_padding
 from .fcn import FCN, GCN, MCFCN, Refine
diff --git a/monai/networks/blocks/dints_block.py b/monai/networks/blocks/dints_block.py
new file mode 100644
index 0000000000..1869e09268
--- /dev/null
+++ b/monai/networks/blocks/dints_block.py
@@ -0,0 +1,265 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+
+from typing import Tuple, Union
+
+import torch
+
+from monai.networks.layers.factories import Conv
+from monai.networks.layers.utils import get_act_layer, get_norm_layer
+
+__all__ = ["FactorizedIncreaseBlock", "FactorizedReduceBlock", "P3DActiConvNormBlock", "ActiConvNormBlock"]
+
+
+class FactorizedIncreaseBlock(torch.nn.Sequential):
+    """
+    Up-sampling the features by two using linear interpolation and convolutions.
+    """
+
+    def __init__(
+        self,
+        in_channel: int,
+        out_channel: int,
+        spatial_dims: int = 3,
+        act_name: Union[Tuple, str] = "RELU",
+        norm_name: Union[Tuple, str] = "INSTANCE",
+    ):
+        """
+        Args:
+            in_channel: number of input channels
+            out_channel: number of output channels
+            spatial_dims: number of spatial dimensions
+            act_name: activation layer type and arguments.
+            norm_name: feature normalization type and arguments.
+        """
+        super().__init__()
+        self._in_channel = in_channel
+        self._out_channel = out_channel
+        self._spatial_dims = spatial_dims
+
+        conv_type = Conv[Conv.CONV, self._spatial_dims]
+
+        self.add_module("up", torch.nn.Upsample(scale_factor=2, mode="trilinear", align_corners=True))
+        self.add_module("acti", get_act_layer(name=act_name))
+        self.add_module(
+            "conv",
+            conv_type(
+                in_channels=self._in_channel,
+                out_channels=self._out_channel,
+                kernel_size=1,
+                stride=1,
+                padding=0,
+                groups=1,
+                bias=False,
+                dilation=1,
+            ),
+        )
+        self.add_module(
+            "norm", get_norm_layer(name=norm_name, spatial_dims=self._spatial_dims, channels=self._out_channel)
+        )
+
+
+class FactorizedReduceBlock(torch.nn.Module):
+    """
+    Down-sampling the feature by 2 using stride.
+    The length along each spatial dimension must be a multiple of 2.
+    """
+
+    def __init__(
+        self,
+        in_channel: int,
+        out_channel: int,
+        spatial_dims: int = 3,
+        act_name: Union[Tuple, str] = "RELU",
+        norm_name: Union[Tuple, str] = "INSTANCE",
+    ):
+        """
+        Args:
+            in_channel: number of input channels
+            out_channel: number of output channels.
+            spatial_dims: number of spatial dimensions.
+            act_name: activation layer type and arguments.
+            norm_name: feature normalization type and arguments.
+        """
+        super().__init__()
+        self._in_channel = in_channel
+        self._out_channel = out_channel
+        self._spatial_dims = spatial_dims
+
+        conv_type = Conv[Conv.CONV, self._spatial_dims]
+
+        self.act = get_act_layer(name=act_name)
+        self.conv_1 = conv_type(
+            in_channels=self._in_channel,
+            out_channels=self._out_channel // 2,
+            kernel_size=1,
+            stride=2,
+            padding=0,
+            groups=1,
+            bias=False,
+            dilation=1,
+        )
+        self.conv_2 = conv_type(
+            in_channels=self._in_channel,
+            out_channels=self._out_channel // 2,
+            kernel_size=1,
+            stride=2,
+            padding=0,
+            groups=1,
+            bias=False,
+            dilation=1,
+        )
+        self.norm = get_norm_layer(name=norm_name, spatial_dims=self._spatial_dims, channels=self._out_channel)
+
+    def forward(self, x: torch.Tensor) -> torch.Tensor:
+        """
+        The length along each spatial dimension must be a multiple of 2.
+        """
+        x = self.act(x)
+        out = torch.cat([self.conv_1(x), self.conv_2(x[:, :, 1:, 1:, 1:])], dim=1)
+        out = self.norm(out)
+        return out
+
+
+class P3DActiConvNormBlock(torch.nn.Sequential):
+    """
+    -- (act) -- (conv) -- (norm) --
+    """
+
+    def __init__(
+        self,
+        in_channel: int,
+        out_channel: int,
+        kernel_size: int,
+        padding: int,
+        mode: int = 0,
+        act_name: Union[Tuple, str] = "RELU",
+        norm_name: Union[Tuple, str] = "INSTANCE",
+    ):
+        """
+        Args:
+            in_channel: number of input channels.
+            out_channel: number of output channels.
+            kernel_size: kernel size to be expanded to 3D.
+            padding: padding size to be expanded to 3D.
+            mode: mode for the anisotropic kernels:
+
+                - 0: ``(k, k, 1)``, ``(1, 1, k)``,
+                - 1: ``(k, 1, k)``, ``(1, k, 1)``,
+                - 2: ``(1, k, k)``. ``(k, 1, 1)``.
+
+            act_name:activation layer type and arguments.
+            norm_name: feature normalization type and arguments.
+        """
+        super().__init__()
+        self._in_channel = in_channel
+        self._out_channel = out_channel
+        self._p3dmode = int(mode)
+
+        conv_type = Conv[Conv.CONV, 3]
+
+        if self._p3dmode == 0:  # (k, k, 1), (1, 1, k)
+            kernel_size0 = (kernel_size, kernel_size, 1)
+            kernel_size1 = (1, 1, kernel_size)
+            padding0 = (padding, padding, 0)
+            padding1 = (0, 0, padding)
+        elif self._p3dmode == 1:  # (k, 1, k), (1, k, 1)
+            kernel_size0 = (kernel_size, 1, kernel_size)
+            kernel_size1 = (1, kernel_size, 1)
+            padding0 = (padding, 0, padding)
+            padding1 = (0, padding, 0)
+        elif self._p3dmode == 2:  # (1, k, k), (k, 1, 1)
+            kernel_size0 = (1, kernel_size, kernel_size)
+            kernel_size1 = (kernel_size, 1, 1)
+            padding0 = (0, padding, padding)
+            padding1 = (padding, 0, 0)
+        else:
+            raise ValueError("`mode` must be 0, 1, or 2.")
+
+        self.add_module("acti", get_act_layer(name=act_name))
+        self.add_module(
+            "conv",
+            conv_type(
+                in_channels=self._in_channel,
+                out_channels=self._in_channel,
+                kernel_size=kernel_size0,
+                stride=1,
+                padding=padding0,
+                groups=1,
+                bias=False,
+                dilation=1,
+            ),
+        )
+        self.add_module(
+            "conv_1",
+            conv_type(
+                in_channels=self._in_channel,
+                out_channels=self._out_channel,
+                kernel_size=kernel_size1,
+                stride=1,
+                padding=padding1,
+                groups=1,
+                bias=False,
+                dilation=1,
+            ),
+        )
+        self.add_module("norm", get_norm_layer(name=norm_name, spatial_dims=3, channels=self._out_channel))
+
+
+class ActiConvNormBlock(torch.nn.Sequential):
+    """
+    -- (Acti) -- (Conv) -- (Norm) --
+    """
+
+    def __init__(
+        self,
+        in_channel: int,
+        out_channel: int,
+        kernel_size: int = 3,
+        padding: int = 1,
+        spatial_dims: int = 3,
+        act_name: Union[Tuple, str] = "RELU",
+        norm_name: Union[Tuple, str] = "INSTANCE",
+    ):
+        """
+        Args:
+            in_channel: number of input channels.
+            out_channel: number of output channels.
+            kernel_size: kernel size of the convolution.
+            padding: padding size of the convolution.
+            spatial_dims: number of spatial dimensions.
+            act_name: activation layer type and arguments.
+            norm_name: feature normalization type and arguments.
+        """
+        super().__init__()
+        self._in_channel = in_channel
+        self._out_channel = out_channel
+        self._spatial_dims = spatial_dims
+
+        conv_type = Conv[Conv.CONV, self._spatial_dims]
+        self.add_module("acti", get_act_layer(name=act_name))
+        self.add_module(
+            "conv",
+            conv_type(
+                in_channels=self._in_channel,
+                out_channels=self._out_channel,
+                kernel_size=kernel_size,
+                stride=1,
+                padding=padding,
+                groups=1,
+                bias=False,
+                dilation=1,
+            ),
+        )
+        self.add_module(
+            "norm", get_norm_layer(name=norm_name, spatial_dims=self._spatial_dims, channels=self._out_channel)
+        )
diff --git a/monai/networks/nets/__init__.py b/monai/networks/nets/__init__.py
index f7348b7b44..3dcb0782ed 100644
--- a/monai/networks/nets/__init__.py
+++ b/monai/networks/nets/__init__.py
@@ -29,6 +29,8 @@
     densenet201,
     densenet264,
 )
+
+# from .dints import DiNTS
 from .dynunet import DynUNet, DynUnet, Dynunet
 from .efficientnet import (
     BlockArgs,
diff --git a/tests/test_acn_block.py b/tests/test_acn_block.py
new file mode 100644
index 0000000000..5e2467a565
--- /dev/null
+++ b/tests/test_acn_block.py
@@ -0,0 +1,38 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+import torch
+from parameterized import parameterized
+
+from monai.networks.blocks.dints_block import ActiConvNormBlock
+
+TEST_CASES = [
+    [{"in_channel": 32, "out_channel": 16, "kernel_size": 3, "padding": 1}, (7, 32, 16, 31, 7), (7, 16, 16, 31, 7)],
+    [
+        {"in_channel": 32, "out_channel": 16, "kernel_size": 3, "padding": 1, "spatial_dims": 2},
+        (7, 32, 13, 32),
+        (7, 16, 13, 32),
+    ],
+]
+
+
+class TestACNBlock(unittest.TestCase):
+    @parameterized.expand(TEST_CASES)
+    def test_acn_block(self, input_param, input_shape, expected_shape):
+        net = ActiConvNormBlock(**input_param)
+        result = net(torch.randn(input_shape))
+        self.assertEqual(result.shape, expected_shape)
+
+
+if __name__ == "__main__":
+    unittest.main()
diff --git a/tests/test_factorized_increase.py b/tests/test_factorized_increase.py
new file mode 100644
index 0000000000..6ef3bb465d
--- /dev/null
+++ b/tests/test_factorized_increase.py
@@ -0,0 +1,34 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+import torch
+from parameterized import parameterized
+
+from monai.networks.blocks.dints_block import FactorizedIncreaseBlock
+
+TEST_CASES_3D = [
+    [{"in_channel": 32, "out_channel": 16}, (7, 32, 24, 16, 8), (7, 16, 48, 32, 16)],
+    [{"in_channel": 1, "out_channel": 2}, (1, 1, 1, 1, 1), (1, 2, 2, 2, 2)],
+]
+
+
+class TestFactInc(unittest.TestCase):
+    @parameterized.expand(TEST_CASES_3D)
+    def test_factorized_increase_3d(self, input_param, input_shape, expected_shape):
+        net = FactorizedIncreaseBlock(**input_param)
+        result = net(torch.randn(input_shape))
+        self.assertEqual(result.shape, expected_shape)
+
+
+if __name__ == "__main__":
+    unittest.main()
diff --git a/tests/test_factorized_reduce.py b/tests/test_factorized_reduce.py
new file mode 100644
index 0000000000..9ed1e8f6ca
--- /dev/null
+++ b/tests/test_factorized_reduce.py
@@ -0,0 +1,34 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+import torch
+from parameterized import parameterized
+
+from monai.networks.blocks.dints_block import FactorizedReduceBlock
+
+TEST_CASES_3D = [
+    [{"in_channel": 32, "out_channel": 16}, (7, 32, 24, 16, 8), (7, 16, 12, 8, 4)],
+    [{"in_channel": 16, "out_channel": 32}, (7, 16, 22, 14, 6), (7, 32, 11, 7, 3)],
+]
+
+
+class TestFactRed(unittest.TestCase):
+    @parameterized.expand(TEST_CASES_3D)
+    def test_factorized_reduce_3d(self, input_param, input_shape, expected_shape):
+        net = FactorizedReduceBlock(**input_param)
+        result = net(torch.randn(input_shape))
+        self.assertEqual(result.shape, expected_shape)
+
+
+if __name__ == "__main__":
+    unittest.main()
diff --git a/tests/test_p3d_block.py b/tests/test_p3d_block.py
new file mode 100644
index 0000000000..b9237cba01
--- /dev/null
+++ b/tests/test_p3d_block.py
@@ -0,0 +1,75 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+import torch
+from parameterized import parameterized
+
+from monai.networks.blocks.dints_block import P3DActiConvNormBlock
+
+TEST_CASES_3D = [
+    [
+        {"in_channel": 32, "out_channel": 16, "kernel_size": 3, "padding": 0, "mode": 0},
+        (7, 32, 16, 32, 8),
+        (7, 16, 14, 30, 6),
+    ],
+    [
+        {"in_channel": 32, "out_channel": 16, "kernel_size": 3, "padding": 1, "mode": 0},  # check padding
+        (7, 32, 16, 32, 8),
+        (7, 16, 16, 32, 8),
+    ],
+    [
+        {"in_channel": 32, "out_channel": 16, "kernel_size": 3, "padding": 0, "mode": 1},
+        (7, 32, 16, 32, 8),
+        (7, 16, 14, 30, 6),
+    ],
+    [
+        {
+            "in_channel": 32,
+            "out_channel": 16,
+            "kernel_size": 3,
+            "padding": 0,
+            "mode": 2,
+            "act_name": ("leakyrelu", {"inplace": True, "negative_slope": 0.2}),
+        },
+        (7, 32, 16, 32, 8),
+        (7, 16, 14, 30, 6),
+    ],
+    [
+        {
+            "in_channel": 32,
+            "out_channel": 16,
+            "kernel_size": 4,
+            "padding": 0,
+            "mode": 0,
+            "norm_name": ("INSTANCE", {"affine": True}),
+        },
+        (7, 32, 16, 32, 8),
+        (7, 16, 13, 29, 5),
+    ],
+]
+
+
+class TestP3D(unittest.TestCase):
+    @parameterized.expand(TEST_CASES_3D)
+    def test_3d(self, input_param, input_shape, expected_shape):
+        net = P3DActiConvNormBlock(**input_param)
+        result = net(torch.randn(input_shape))
+        self.assertEqual(result.shape, expected_shape)
+
+    def test_ill(self):
+        with self.assertRaises(ValueError):
+            P3DActiConvNormBlock(in_channel=32, out_channel=16, kernel_size=3, padding=0, mode=3)
+
+
+if __name__ == "__main__":
+    unittest.main()