diff --git a/monai/data/meta_tensor.py b/monai/data/meta_tensor.py
index 0b6a4b7b19..5911e218ee 100644
--- a/monai/data/meta_tensor.py
+++ b/monai/data/meta_tensor.py
@@ -18,6 +18,7 @@
 import numpy as np
 import torch
 
+import monai
 from monai.config.type_definitions import NdarrayTensor
 from monai.data.meta_obj import MetaObj, get_track_meta
 from monai.data.utils import affine_to_spacing, decollate_batch, list_data_collate, remove_extra_metadata
@@ -461,7 +462,9 @@ def clone(self):
         return new_inst
 
     @staticmethod
-    def ensure_torch_and_prune_meta(im: NdarrayTensor, meta: dict, simple_keys: bool = False):
+    def ensure_torch_and_prune_meta(
+        im: NdarrayTensor, meta: dict, simple_keys: bool = False, pattern: str | None = None, sep: str = "."
+    ):
         """
         Convert the image to `torch.Tensor`. If `affine` is in the `meta` dictionary,
         convert that to `torch.Tensor`, too. Remove any superfluous metadata.
@@ -470,6 +473,11 @@ def ensure_torch_and_prune_meta(im: NdarrayTensor, meta: dict, simple_keys: bool
             im: Input image (`np.ndarray` or `torch.Tensor`)
             meta: Metadata dictionary.
             simple_keys: whether to keep only a simple subset of metadata keys.
+            pattern: combined with `sep`, a regular expression used to match and prune keys
+                in the metadata (nested dictionary), default to None, no key deletion.
+            sep: combined with `pattern`, used to match and delete keys in the metadata (nested dictionary).
+                default is ".", see also :py:class:`monai.transforms.DeleteItemsd`.
+                e.g. ``pattern=".*_code$", sep=" "`` removes any meta keys that ends with ``"_code"``.
 
         Returns:
             By default, a `MetaTensor` is returned.
@@ -488,6 +496,9 @@ def ensure_torch_and_prune_meta(im: NdarrayTensor, meta: dict, simple_keys: bool
                 meta[MetaKeys.AFFINE] = convert_to_tensor(meta[MetaKeys.AFFINE])  # bc-breaking
             remove_extra_metadata(meta)  # bc-breaking
 
+        if pattern is not None:
+            meta = monai.transforms.DeleteItemsd(keys=pattern, sep=sep, use_re=True)(meta)
+
         # return the `MetaTensor`
         return MetaTensor(img, meta=meta)
 
diff --git a/monai/transforms/io/array.py b/monai/transforms/io/array.py
index 8dd849d33e..dc43475b63 100644
--- a/monai/transforms/io/array.py
+++ b/monai/transforms/io/array.py
@@ -112,6 +112,8 @@ def __init__(
         dtype: DtypeLike = np.float32,
         ensure_channel_first: bool = False,
         simple_keys: bool = False,
+        prune_meta_pattern: Optional[str] = None,
+        prune_meta_sep: str = ".",
         *args,
         **kwargs,
     ) -> None:
@@ -129,6 +131,11 @@ def __init__(
             ensure_channel_first: if `True` and loaded both image array and metadata, automatically convert
                 the image array shape to `channel first`. default to `False`.
             simple_keys: whether to remove redundant metadata keys, default to False for backward compatibility.
+            prune_meta_pattern: combined with `prune_meta_sep`, a regular expression used to match and prune keys
+                in the metadata (nested dictionary), default to None, no key deletion.
+            prune_meta_sep: combined with `prune_meta_pattern`, used to match and prune keys
+                in the metadata (nested dictionary). default is ".", see also :py:class:`monai.transforms.DeleteItemsd`.
+                e.g. ``prune_meta_pattern=".*_code$", prune_meta_sep=" "`` removes meta keys that ends with ``"_code"``.
             args: additional parameters for reader if providing a reader name.
             kwargs: additional parameters for reader if providing a reader name.
 
@@ -148,6 +155,8 @@ def __init__(
         self.dtype = dtype
         self.ensure_channel_first = ensure_channel_first
         self.simple_keys = simple_keys
+        self.pattern = prune_meta_pattern
+        self.sep = prune_meta_sep
 
         self.readers: List[ImageReader] = []
         for r in SUPPORTED_READERS:  # set predefined readers as default
@@ -258,7 +267,9 @@ def __call__(self, filename: Union[Sequence[PathLike], PathLike], reader: Option
         meta_data = switch_endianness(meta_data, "<")
 
         meta_data[Key.FILENAME_OR_OBJ] = f"{ensure_tuple(filename)[0]}"  # Path obj should be strings for data loader
-        img = MetaTensor.ensure_torch_and_prune_meta(img_array, meta_data, self.simple_keys)
+        img = MetaTensor.ensure_torch_and_prune_meta(
+            img_array, meta_data, self.simple_keys, pattern=self.pattern, sep=self.sep
+        )
         if self.ensure_channel_first:
             img = EnsureChannelFirst()(img)
         if self.image_only:
diff --git a/monai/transforms/io/dictionary.py b/monai/transforms/io/dictionary.py
index 42918f5e63..761c891e85 100644
--- a/monai/transforms/io/dictionary.py
+++ b/monai/transforms/io/dictionary.py
@@ -75,6 +75,8 @@ def __init__(
         image_only: bool = False,
         ensure_channel_first: bool = False,
         simple_keys: bool = False,
+        prune_meta_pattern: Optional[str] = None,
+        prune_meta_sep: str = ".",
         allow_missing_keys: bool = False,
         *args,
         **kwargs,
@@ -105,12 +107,27 @@ def __init__(
             ensure_channel_first: if `True` and loaded both image array and metadata, automatically convert
                 the image array shape to `channel first`. default to `False`.
             simple_keys: whether to remove redundant metadata keys, default to False for backward compatibility.
+            prune_meta_pattern: combined with `prune_meta_sep`, a regular expression used to match and prune keys
+                in the metadata (nested dictionary), default to None, no key deletion.
+            prune_meta_sep: combined with `prune_meta_pattern`, used to match and prune keys
+                in the metadata (nested dictionary). default is ".", see also :py:class:`monai.transforms.DeleteItemsd`.
+                e.g. ``prune_meta_pattern=".*_code$", prune_meta_sep=" "`` removes meta keys that ends with ``"_code"``.
             allow_missing_keys: don't raise exception if key is missing.
             args: additional parameters for reader if providing a reader name.
             kwargs: additional parameters for reader if providing a reader name.
         """
         super().__init__(keys, allow_missing_keys)
-        self._loader = LoadImage(reader, image_only, dtype, ensure_channel_first, simple_keys, *args, **kwargs)
+        self._loader = LoadImage(
+            reader,
+            image_only,
+            dtype,
+            ensure_channel_first,
+            simple_keys,
+            prune_meta_pattern,
+            prune_meta_sep,
+            *args,
+            **kwargs,
+        )
         if not isinstance(meta_key_postfix, str):
             raise TypeError(f"meta_key_postfix must be a str but is {type(meta_key_postfix).__name__}.")
         self.meta_keys = ensure_tuple_rep(None, len(self.keys)) if meta_keys is None else ensure_tuple(meta_keys)
diff --git a/monai/transforms/utility/dictionary.py b/monai/transforms/utility/dictionary.py
index 073e50a3be..2c4394a7da 100644
--- a/monai/transforms/utility/dictionary.py
+++ b/monai/transforms/utility/dictionary.py
@@ -718,7 +718,7 @@ def __init__(self, keys: KeysCollection, sep: str = ".", use_re: Union[Sequence[
                 See also: :py:class:`monai.transforms.compose.MapTransform`
             sep: the separator tag to define nested dictionary keys, default to ".".
             use_re: whether the specified key is a regular expression, it also can be
-                a list of bool values, map the to keys.
+                a list of bool values, mapping them to `keys`.
         """
         super().__init__(keys)
         self.sep = sep
@@ -730,7 +730,7 @@ def _delete_item(keys, d, use_re: bool = False):
             if len(keys) > 1:
                 d[key] = _delete_item(keys[1:], d[key], use_re)
                 return d
-            return {k: v for k, v in d.items() if (use_re and not re.search(key, k)) or (not use_re and k != key)}
+            return {k: v for k, v in d.items() if (use_re and not re.search(key, f"{k}")) or (not use_re and k != key)}
 
         d = dict(data)
         for key, use_re in zip(self.keys, self.use_re):
diff --git a/tests/test_load_image.py b/tests/test_load_image.py
index e6dfae0901..cc227021a2 100644
--- a/tests/test_load_image.py
+++ b/tests/test_load_image.py
@@ -332,12 +332,13 @@ def tearDownClass(cls):
     @parameterized.expand(TESTS_META)
     def test_correct(self, input_param, expected_shape, track_meta):
         set_track_meta(track_meta)
-        r = LoadImage(image_only=True, **input_param)(self.test_data)
+        r = LoadImage(image_only=True, prune_meta_pattern="glmax", prune_meta_sep="%", **input_param)(self.test_data)
         self.assertTupleEqual(r.shape, expected_shape)
         if track_meta:
             self.assertIsInstance(r, MetaTensor)
             self.assertTrue(hasattr(r, "affine"))
             self.assertIsInstance(r.affine, torch.Tensor)
+            self.assertTrue("glmax" not in r.meta)
         else:
             self.assertIsInstance(r, torch.Tensor)
             self.assertNotIsInstance(r, MetaTensor)
diff --git a/tests/test_load_imaged.py b/tests/test_load_imaged.py
index 096fbafa06..cd8b476a58 100644
--- a/tests/test_load_imaged.py
+++ b/tests/test_load_imaged.py
@@ -164,9 +164,11 @@ def tearDownClass(cls):
         super(__class__, cls).tearDownClass()
 
     @parameterized.expand(TESTS_META)
-    def test_correct(self, input_param, expected_shape, track_meta):
+    def test_correct(self, input_p, expected_shape, track_meta):
         set_track_meta(track_meta)
-        result = LoadImaged(image_only=True, **input_param)(self.test_data)
+        result = LoadImaged(image_only=True, prune_meta_pattern=".*_code$", prune_meta_sep=" ", **input_p)(
+            self.test_data
+        )
 
         # shouldn't have any extra meta data keys
         self.assertEqual(len(result), len(KEYS))
@@ -178,6 +180,7 @@ def test_correct(self, input_param, expected_shape, track_meta):
                 self.assertTrue(hasattr(r, "affine"))
                 self.assertIsInstance(r.affine, torch.Tensor)
                 self.assertEqual(r.meta["space"], "RAS")
+                self.assertTrue("qform_code" not in r.meta)
             else:
                 self.assertIsInstance(r, torch.Tensor)
                 self.assertNotIsInstance(r, MetaTensor)