diff --git a/newsfragments/4981.fixed.md b/newsfragments/4981.fixed.md
new file mode 100644
index 00000000000..0ac31b19a11
--- /dev/null
+++ b/newsfragments/4981.fixed.md
@@ -0,0 +1 @@
+Fix `is_type_of` for native types not using same specialized check as `is_type_of_bound`.
diff --git a/src/types/mod.rs b/src/types/mod.rs
index e3a317ea33a..637d07d72b6 100644
--- a/src/types/mod.rs
+++ b/src/types/mod.rs
@@ -152,7 +152,7 @@ macro_rules! pyobject_native_type_info(
 
             $(
                 #[inline]
-                fn is_type_of_bound(obj: &$crate::Bound<'_, $crate::PyAny>) -> bool {
+                fn is_type_of(obj: &$crate::Bound<'_, $crate::PyAny>) -> bool {
                     #[allow(unused_unsafe)]
                     unsafe { $checkfunction(obj.as_ptr()) > 0 }
                 }