diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 9280573518..ba3a877491 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -238,6 +238,10 @@ Improvements
 
   Contributed by @ashwini-orchestral
 
+* Drop unused python dependencies: prometheus_client, python-gnupg, more-itertools, zipp. #5228
+
+  Contributed by @cognifloyd.
+
 Fixed
 ~~~~~
 
diff --git a/fixed-requirements.txt b/fixed-requirements.txt
index 342582d79d..a289f9275e 100644
--- a/fixed-requirements.txt
+++ b/fixed-requirements.txt
@@ -32,7 +32,6 @@ prompt-toolkit==1.0.15
 pyinotify==0.9.6; platform_system=="Linux"
 pymongo==3.11.3
 python-editor==1.0.4
-python-gnupg==0.4.5
 python-keyczar==0.716
 pytz==2021.1
 pywinrm==0.3.0
@@ -56,14 +55,11 @@ zake==0.2.2
 bcrypt==3.2.0
 jinja2==2.11.3
 mock==4.0.3
-more-itertools==5.0.0
 nose-timer==0.7.5
 nose-parallel==0.3.1
 psutil==5.8.0
 python-dateutil==2.8.1
 python-statsd==2.1.0
-prometheus_client==0.1.1
 ujson==1.35
 orjson==3.5.1
 udatetime==0.0.16
-zipp>=0.5,<=1.0.0
diff --git a/requirements.txt b/requirements.txt
index da1088a468..cabec5c31b 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -30,7 +30,6 @@ kombu==4.6.6
 lockfile==0.12.2
 mock==4.0.3
 mongoengine==0.23.0
-more-itertools==5.0.0
 networkx==1.11
 nose
 nose-parallel==0.3.1
@@ -69,4 +68,3 @@ unittest2
 webob==1.8.7
 webtest
 zake==0.2.2
-zipp>=0.5,<=1.0.0
diff --git a/st2client/in-requirements.txt b/st2client/in-requirements.txt
index 13d0f3cf7f..6d1341e742 100644
--- a/st2client/in-requirements.txt
+++ b/st2client/in-requirements.txt
@@ -13,7 +13,5 @@ python-editor
 prompt-toolkit
 cryptography
 orjson
-more-itertools==5.0.0
-zipp>=0.5,<=1.0.0
 # needed by requests
 chardet
diff --git a/st2client/requirements.txt b/st2client/requirements.txt
index ab436c7878..5103232989 100644
--- a/st2client/requirements.txt
+++ b/st2client/requirements.txt
@@ -10,7 +10,6 @@ chardet<3.1.0
 cryptography==3.4.7
 jsonpath-rw==1.4.0
 jsonschema==2.6.0
-more-itertools==5.0.0
 orjson==3.5.1
 prettytable
 prompt-toolkit==1.0.15
@@ -21,4 +20,3 @@ pyyaml==5.4
 requests[security]==2.25.1
 six==1.13.0
 sseclient-py==1.7
-zipp>=0.5,<=1.0.0