diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 6770482b3a..c1091ef86a 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -169,6 +169,10 @@ Fixed
 
   Contributed by @khushboobhatia01
 
+* Fixed issue where pack index searches are ignoring no_proxy #5497
+
+  Contributed by @minsis
+
 3.6.0 - October 29, 2021
 ------------------------
 
diff --git a/st2common/st2common/services/packs.py b/st2common/st2common/services/packs.py
index 6633fbefde..ee2d937758 100644
--- a/st2common/st2common/services/packs.py
+++ b/st2common/st2common/services/packs.py
@@ -20,6 +20,7 @@
 
 import os
 import requests
+from requests.utils import should_bypass_proxies
 import six
 from six.moves import range
 from oslo_config import cfg
@@ -83,6 +84,7 @@ def _fetch_and_compile_index(index_urls, logger=None, proxy_config=None):
     if proxy_config:
         https_proxy = proxy_config.get("https_proxy", None)
         http_proxy = proxy_config.get("http_proxy", None)
+        no_proxy = proxy_config.get("no_proxy", None)
         ca_bundle_path = proxy_config.get("proxy_ca_bundle_path", None)
 
         if https_proxy:
@@ -92,7 +94,17 @@ def _fetch_and_compile_index(index_urls, logger=None, proxy_config=None):
         if http_proxy:
             proxies_dict["http"] = http_proxy
 
+        if no_proxy:
+            proxies_dict["no"] = no_proxy
+
     for index_url in index_urls:
+
+        # TODO:
+        # Bug  in requests doesn't bypass proxies, so we do it ourselves
+        # If this issue ever gets fixed then we can remove it
+        # https://github.com/psf/requests/issues/4871
+        bypass_proxy = should_bypass_proxies(index_url, proxies_dict.get("no"))
+
         index_status = {
             "url": index_url,
             "packs": 0,
@@ -102,7 +114,11 @@ def _fetch_and_compile_index(index_urls, logger=None, proxy_config=None):
         index_json = None
 
         try:
-            request = requests.get(index_url, proxies=proxies_dict, verify=verify)
+            request = requests.get(
+                index_url,
+                proxies=proxies_dict if not bypass_proxy else None,
+                verify=verify if not bypass_proxy else True,
+            )
             request.raise_for_status()
             index_json = request.json()
         except ValueError as e: