diff --git a/.storybook/custom-addons/provider/index.js b/.storybook/custom-addons/provider/index.js
index 5c8ea217863..5403b97bbfa 100644
--- a/.storybook/custom-addons/provider/index.js
+++ b/.storybook/custom-addons/provider/index.js
@@ -18,7 +18,7 @@ function ProviderUpdater(props) {
   let [themeValue, setTheme] = useState(providerValuesFromUrl.theme || undefined);
   let [scaleValue, setScale] = useState(providerValuesFromUrl.scale || undefined);
   let [expressValue, setExpress] = useState(providerValuesFromUrl.express === 'true');
-  let [storyReady, setStoryReady] = useState(window.parent === window); // reduce content flash because it takes a moment to get the provider details
+  let [storyReady, setStoryReady] = useState(window.parent === window || window.parent !== window.top); // reduce content flash because it takes a moment to get the provider details
   // Typically themes are provided with both light + dark, and both scales.
   // To build our selector to see all themes, we need to hack it a bit.
   let theme = (expressValue ? expressThemes : themes)[themeValue || 'light'] || defaultTheme;
diff --git a/packages/@react-aria/landmark/src/useLandmark.ts b/packages/@react-aria/landmark/src/useLandmark.ts
index 4f835a6a1a4..43823aa4140 100644
--- a/packages/@react-aria/landmark/src/useLandmark.ts
+++ b/packages/@react-aria/landmark/src/useLandmark.ts
@@ -17,7 +17,8 @@ import {useLayoutEffect} from '@react-aria/utils';
 export type AriaLandmarkRole = 'main' | 'region' | 'search' | 'navigation' | 'form' | 'banner' | 'contentinfo' | 'complementary';
 
 export interface AriaLandmarkProps extends AriaLabelingProps {
-  role: AriaLandmarkRole
+  role: AriaLandmarkRole,
+  focus?: (direction: 'forward' | 'backward') => void
 }
 
 export interface LandmarkAria {
@@ -29,7 +30,7 @@ type Landmark = {
   role: AriaLandmarkRole,
   label?: string,
   lastFocused?: FocusableElement,
-  focus: () => void,
+  focus: (direction: 'forward' | 'backward') => void,
   blur: () => void
 };
 
@@ -66,8 +67,8 @@ class LandmarkManager {
     this.isListening = false;
   }
 
-  private focusLandmark(landmark: Element) {
-    this.landmarks.find(l => l.ref.current === landmark)?.focus();
+  private focusLandmark(landmark: Element, direction: 'forward' | 'backward') {
+    this.landmarks.find(l => l.ref.current === landmark)?.focus(direction);
   }
 
   /**
@@ -190,16 +191,46 @@ class LandmarkManager {
     }
 
     let currentLandmark = this.closestLandmark(element);
-    let nextLandmarkIndex = backward ? -1 : 0;
+    let nextLandmarkIndex = backward ? this.landmarks.length - 1 : 0;
     if (currentLandmark) {
-      nextLandmarkIndex = this.landmarks.findIndex(landmark => landmark === currentLandmark) + (backward ? -1 : 1);
+      nextLandmarkIndex = this.landmarks.indexOf(currentLandmark) + (backward ? -1 : 1);
     }
 
-    // Wrap if necessary
-    if (nextLandmarkIndex < 0) {
-      nextLandmarkIndex = this.landmarks.length - 1;
-    } else if (nextLandmarkIndex >= this.landmarks.length) {
-      nextLandmarkIndex = 0;
+    let wrapIfNeeded = () => {
+      // When we reach the end of the landmark sequence, fire a custom event that can be listened for by applications.
+      // If this event is canceled, we return immediately. This can be used to implement landmark navigation across iframes.
+      if (nextLandmarkIndex < 0) {
+        if (!element.dispatchEvent(new CustomEvent('react-aria-landmark-navigation', {detail: {direction: 'backward'}, bubbles: true, cancelable: true}))) {
+          return true;
+        }
+
+        nextLandmarkIndex = this.landmarks.length - 1;
+      } else if (nextLandmarkIndex >= this.landmarks.length) {
+        if (!element.dispatchEvent(new CustomEvent('react-aria-landmark-navigation', {detail: {direction: 'forward'}, bubbles: true, cancelable: true}))) {
+          return true;
+        }
+
+        nextLandmarkIndex = 0;
+      }
+
+      return false;
+    };
+
+    if (wrapIfNeeded()) {
+      return undefined;
+    }
+
+    // Skip over hidden landmarks.
+    let i = nextLandmarkIndex;
+    while (this.landmarks[nextLandmarkIndex].ref.current.closest('[aria-hidden]')) {
+      nextLandmarkIndex += backward ? -1 : 1;
+      if (wrapIfNeeded()) {
+        return undefined;
+      }
+
+      if (nextLandmarkIndex === i) {
+        break;
+      }
     }
 
     return this.landmarks[nextLandmarkIndex];
@@ -212,9 +243,6 @@ class LandmarkManager {
    */
   public f6Handler(e: KeyboardEvent) {
     if (e.key === 'F6') {
-      e.preventDefault();
-      e.stopPropagation();
-
       let backward = e.shiftKey;
       let nextLandmark = this.getNextLandmark(e.target as Element, {backward});
 
@@ -223,11 +251,14 @@ class LandmarkManager {
         return;
       }
 
+      e.preventDefault();
+      e.stopPropagation();
+
       // If alt key pressed, focus main landmark
       if (e.altKey) {
         let main = this.getLandmarkByRole('main');
         if (main && document.contains(main.ref.current)) {
-          this.focusLandmark(main.ref.current);
+          this.focusLandmark(main.ref.current, 'forward');
         }
         return;
       }
@@ -243,7 +274,7 @@ class LandmarkManager {
 
       // Otherwise, focus the landmark itself
       if (document.contains(nextLandmark.ref.current)) {
-        this.focusLandmark(nextLandmark.ref.current);
+        this.focusLandmark(nextLandmark.ref.current, backward ? 'backward' : 'forward');
       }
     }
   }
@@ -292,13 +323,14 @@ export function useLandmark(props: AriaLandmarkProps, ref: MutableRefObject<Focu
   const {
     role,
     'aria-label': ariaLabel,
-    'aria-labelledby': ariaLabelledby
+    'aria-labelledby': ariaLabelledby,
+    focus
   } = props;
   let manager = LandmarkManager.getInstance();
   let label = ariaLabel || ariaLabelledby;
   let [isLandmarkFocused, setIsLandmarkFocused] = useState(false);
 
-  let focus = useCallback(() => {
+  let defaultFocus = useCallback(() => {
     setIsLandmarkFocused(true);
   }, [setIsLandmarkFocused]);
 
@@ -316,7 +348,7 @@ export function useLandmark(props: AriaLandmarkProps, ref: MutableRefObject<Focu
   }, []);
 
   useLayoutEffect(() => {
-    manager.updateLandmark({ref, label, role, focus, blur});
+    manager.updateLandmark({ref, label, role, focus: focus || defaultFocus, blur});
   // eslint-disable-next-line react-hooks/exhaustive-deps
   }, [label, ref, role]);
 
diff --git a/packages/@react-aria/landmark/stories/Landmark.stories.tsx b/packages/@react-aria/landmark/stories/Landmark.stories.tsx
index 8615322cbfe..7ffc8a49070 100644
--- a/packages/@react-aria/landmark/stories/Landmark.stories.tsx
+++ b/packages/@react-aria/landmark/stories/Landmark.stories.tsx
@@ -17,7 +17,7 @@ import {classNames, useStyleProps} from '@react-spectrum/utils';
 import {Flex} from '@react-spectrum/layout';
 import {Link} from '@react-spectrum/link';
 import {Meta, Story} from '@storybook/react';
-import React, {useRef} from 'react';
+import React, {SyntheticEvent, useEffect, useRef} from 'react';
 import {SearchField} from '@react-spectrum/searchfield';
 import styles from './index.css';
 import {TextField} from '@react-spectrum/textfield';
@@ -69,7 +69,7 @@ function Search(props) {
   let {styleProps} = useStyleProps(props);
   let {landmarkProps} = useLandmark({...props, role: 'search'}, ref);
   return (
-    <form aria-label="Magic seeing eye" ref={ref} {...props} {...landmarkProps} {...styleProps}>
+    <form aria-label="Magic seeing eye" ref={ref} {...props} {...landmarkProps} {...styleProps} className={classNames(styles, 'landmark')}>
       <SearchField label="Search" />
     </form>
   );
@@ -313,6 +313,104 @@ function ApplicationExample() {
   );
 }
 
+function IframeExample() {
+  let onLoad = (e: SyntheticEvent) => {
+    let iframe = e.target as HTMLIFrameElement;
+    let window = iframe.contentWindow;
+    let document = window.document;
+
+    let prevFocusedElement = null;
+    window.addEventListener('react-aria-landmark-navigation', (e: CustomEvent) => {
+      e.preventDefault();
+      let el = document.activeElement;
+      if (el !== document.body) {
+        prevFocusedElement = el;
+      }
+
+      // Prevent focus scope from stealing focus back when we move focus to the iframe.
+      document.body.setAttribute('data-react-aria-top-layer', 'true');
+
+      window.parent.postMessage({
+        type: 'landmark-navigation',
+        direction: e.detail.direction
+      });
+
+      setTimeout(() => {
+        document.body.removeAttribute('data-react-aria-top-layer');
+      }, 100);
+    });
+
+    // When the iframe is re-focused, restore focus back inside where it was before.
+    window.addEventListener('focus', () => {
+      if (prevFocusedElement) {
+        prevFocusedElement.focus();
+        prevFocusedElement = null;
+      }
+    });
+
+    // Move focus to first or last landmark when we receive a message from the parent page.
+    window.addEventListener('message', e => {
+      if (e.data.type === 'landmark-navigation') {
+        document.body.dispatchEvent(new KeyboardEvent('keydown', {key: 'F6', shiftKey: e.data.direction === 'backward', bubbles: true}));
+      }
+    });
+  };
+
+  useEffect(() => {
+    let onMessage = (e: MessageEvent) => {
+      let iframe = ref.current;
+      if (e.data.type === 'landmark-navigation') {
+        // Move focus to the iframe so that when focus is restored there, and we can redirect it back inside (below).
+        iframe.focus();
+
+        // Now re-dispatch the keyboard event so landmark navigation outside the iframe picks it up.
+        iframe.dispatchEvent(new KeyboardEvent('keydown', {key: 'F6', shiftKey: e.data.direction === 'backward', bubbles: true}));
+      }
+    };
+
+    window.addEventListener('message', onMessage);
+    return () => window.removeEventListener('message', onMessage);
+  }, []);
+
+  let ref = useRef(null);
+  let {landmarkProps} = useLandmark({
+    role: 'main',
+    focus(direction) {
+      // when iframe landmark receives focus via landmark navigation, go to first/last landmark inside iframe.
+      ref.current.contentWindow.postMessage({
+        type: 'landmark-navigation',
+        direction
+      });
+    }
+  }, ref);
+
+  return (
+    <div className={classNames(styles, 'application')}>
+      <Region UNSAFE_className={classNames(styles, 'globalnav')}>
+        <Flex justifyContent="space-between">
+          <Link><a href="//react-spectrum.com">React Spectrum</a></Link>
+          <Search />
+        </Flex>
+      </Region>
+      <Navigation UNSAFE_className={classNames(styles, 'navigation')} aria-label="Site Nav">
+        <ActionGroup orientation="vertical">
+          <Item>One</Item>
+          <Item>Two</Item>
+          <Item>Three</Item>
+        </ActionGroup>
+      </Navigation>
+      <iframe
+        ref={ref}
+        {...landmarkProps}
+        title="iframe"
+        style={{width: '100%', height: '100%'}}
+        src="iframe.html?providerSwitcher-express=false&providerSwitcher-toastPosition=bottom&providerSwitcher-locale=&providerSwitcher-theme=&providerSwitcher-scale=&args=&id=landmark--application-with-landmarks&viewMode=story"
+        onLoad={onLoad}
+        tabIndex={-1} />
+    </div>
+  );
+}
+
 export const FlatLandmarks = Template().bind({});
 FlatLandmarks.args = {};
 
@@ -339,3 +437,5 @@ OneWithNoFocusableChildren.args = {};
 
 export const AllWithNoFocusableChildren = AllWithNoFocusableChildrenExampleTemplate().bind({});
 AllWithNoFocusableChildren.args = {};
+
+export {IframeExample};
diff --git a/packages/@react-aria/landmark/stories/index.css b/packages/@react-aria/landmark/stories/index.css
index abd73a38d0e..59904d8e67a 100644
--- a/packages/@react-aria/landmark/stories/index.css
+++ b/packages/@react-aria/landmark/stories/index.css
@@ -9,22 +9,40 @@
     "globalnav  globalnav globalnav"
     "navigation content   navcontent";
 }
+
+.landmark {
+  outline: none;
+  position: relative;
+  &:focus:after {
+    content: '';
+    position: absolute;
+    inset: 1px;
+    border: 2px solid black;
+    z-index: 1000;
+    box-shadow: 0 0 0 1px white, inset 0 0 0 1px white;
+  }
+}
+
 .globalnav {
+  composes: landmark;
   grid-area: globalnav;
   padding: 10px;
   background: var(--spectrum-alias-categorical-color-6);
 }
 .navigation {
+  composes: landmark;
   grid-area: navigation;
   padding: 10px;
   background: var(--spectrum-alias-categorical-color-2);
 }
 .main {
+  composes: landmark;
   grid-area: content;
   padding: 10px;
   background: var(--spectrum-alias-categorical-color-3);
 }
 .navigation-content {
+  composes: landmark;
   grid-area: navcontent;
   padding: 10px;
   background: var(--spectrum-alias-categorical-color-4);
diff --git a/packages/@react-aria/landmark/test/useLandmark.test.tsx b/packages/@react-aria/landmark/test/useLandmark.test.tsx
index 07357b34ced..60e50271a71 100644
--- a/packages/@react-aria/landmark/test/useLandmark.test.tsx
+++ b/packages/@react-aria/landmark/test/useLandmark.test.tsx
@@ -1156,4 +1156,122 @@ describe('LandmarkManager', function () {
     expect(nav).toHaveAttribute('tabIndex', '-1');
     expect(document.activeElement).toBe(nav);
   });
+
+  it('landmark navigation fires custom event when wrapping forward', function () {
+    let tree = render(
+      <div>
+        <Navigation>
+          <ul>
+            <li><a href="/home">Home</a></li>
+            <li><a href="/about">About</a></li>
+            <li><a href="/contact">Contact</a></li>
+          </ul>
+        </Navigation>
+        <Main>
+          <TextField label="First Name" />
+        </Main>
+      </div>
+    );
+    let main = tree.getByRole('main');
+
+    let onLandmarkNavigation = jest.fn().mockImplementation(e => e.preventDefault());
+    window.addEventListener('react-aria-landmark-navigation', onLandmarkNavigation);
+
+    userEvent.tab();
+    expect(document.activeElement).toBe(tree.getAllByRole('link')[0]);
+
+    fireEvent.keyDown(document.activeElement, {key: 'F6'});
+    fireEvent.keyUp(document.activeElement, {key: 'F6'});
+    expect(document.activeElement).toBe(main);
+
+    fireEvent.keyDown(document.activeElement, {key: 'F6'});
+    fireEvent.keyUp(document.activeElement, {key: 'F6'});
+
+    expect(document.activeElement).toBe(main);
+
+    expect(onLandmarkNavigation).toHaveBeenCalledTimes(1);
+    expect(onLandmarkNavigation.mock.calls[0][0].detail).toEqual({
+      direction: 'forward'
+    });
+
+    window.removeEventListener('react-aria-landmark-navigation', onLandmarkNavigation);
+  });
+
+  it('landmark navigation fires custom event when wrapping backward', function () {
+    let tree = render(
+      <div>
+        <Navigation>
+          <ul>
+            <li><a href="/home">Home</a></li>
+            <li><a href="/about">About</a></li>
+            <li><a href="/contact">Contact</a></li>
+          </ul>
+        </Navigation>
+        <Main>
+          <TextField label="First Name" />
+        </Main>
+      </div>
+    );
+
+    let onLandmarkNavigation = jest.fn().mockImplementation(e => e.preventDefault());
+    window.addEventListener('react-aria-landmark-navigation', onLandmarkNavigation);
+
+    userEvent.tab();
+    expect(document.activeElement).toBe(tree.getAllByRole('link')[0]);
+
+    fireEvent.keyDown(document.activeElement, {key: 'F6', shiftKey: true});
+    fireEvent.keyUp(document.activeElement, {key: 'F6', shiftKey: true});
+    expect(document.activeElement).toBe(tree.getAllByRole('link')[0]);
+
+    expect(onLandmarkNavigation).toHaveBeenCalledTimes(1);
+    expect(onLandmarkNavigation.mock.calls[0][0].detail).toEqual({
+      direction: 'backward'
+    });
+
+    window.removeEventListener('react-aria-landmark-navigation', onLandmarkNavigation);
+  });
+
+  it('skips over aria-hidden landmarks', function () {
+    let tree = render(
+      <div>
+        <Main>
+          <div aria-hidden="true">
+            <Region aria-label="Region 1">
+              <Checkbox>Checkbox label 1</Checkbox>
+            </Region>
+          </div>
+
+          <TextField label="First Name" />
+
+          <Region aria-label="Region 2">
+            <Checkbox>Checkbox label 2</Checkbox>
+          </Region>
+
+          <TextField label="Last Name" />
+        </Main>
+      </div>
+    );
+    let main = tree.getByRole('main');
+    let region2 = tree.getAllByRole('region')[0];
+
+    fireEvent.keyDown(document.activeElement, {key: 'F6'});
+    fireEvent.keyUp(document.activeElement, {key: 'F6'});
+    expect(document.activeElement).toBe(main);
+
+    fireEvent.keyDown(document.activeElement, {key: 'F6'});
+    fireEvent.keyUp(document.activeElement, {key: 'F6'});
+    expect(document.activeElement).toBe(region2);
+
+    fireEvent.keyDown(document.activeElement, {key: 'F6'});
+    fireEvent.keyUp(document.activeElement, {key: 'F6'});
+    expect(document.activeElement).toBe(main);
+
+    fireEvent.keyDown(document.activeElement, {key: 'F6', shiftKey: true});
+    fireEvent.keyUp(document.activeElement, {key: 'F6', shiftKey: true});
+    expect(document.activeElement).toBe(region2);
+
+    fireEvent.keyDown(document.activeElement, {key: 'F6', shiftKey: true});
+    fireEvent.keyUp(document.activeElement, {key: 'F6', shiftKey: true});
+    expect(document.activeElement).toBe(main);
+  });
 });
diff --git a/packages/@react-aria/overlays/src/ariaHideOutside.ts b/packages/@react-aria/overlays/src/ariaHideOutside.ts
index d207ad7ac53..791aa9b6e8b 100644
--- a/packages/@react-aria/overlays/src/ariaHideOutside.ts
+++ b/packages/@react-aria/overlays/src/ariaHideOutside.ts
@@ -27,38 +27,54 @@ export function ariaHideOutside(targets: Element[], root = document.body) {
   let visibleNodes = new Set<Element>(targets);
   let hiddenNodes = new Set<Element>();
 
-  // Keep live announcer and top layer elements (e.g. toasts) visible.
-  for (let element of document.querySelectorAll('[data-live-announcer], [data-react-aria-top-layer]')) {
-    visibleNodes.add(element);
-  }
+  let walk = (root: Element) => {
+    // Keep live announcer and top layer elements (e.g. toasts) visible.
+    for (let element of root.querySelectorAll('[data-live-announcer], [data-react-aria-top-layer]')) {
+      visibleNodes.add(element);
+    }
 
-  let walker = document.createTreeWalker(
-    root,
-    NodeFilter.SHOW_ELEMENT,
-    {
-      acceptNode(node) {
-        // Skip this node and its children if it is one of the target nodes, or a live announcer.
-        // Also skip children of already hidden nodes, as aria-hidden is recursive. An exception is
-        // made for elements with role="row" since VoiceOver on iOS has issues hiding elements with role="row".
-        // For that case we want to hide the cells inside as well (https://bugs.webkit.org/show_bug.cgi?id=222623).
-        if (
-          visibleNodes.has(node as Element) ||
-          (hiddenNodes.has(node.parentElement) && node.parentElement.getAttribute('role') !== 'row')
-        ) {
-          return NodeFilter.FILTER_REJECT;
-        }
+    let acceptNode = (node: Element) => {
+      // Skip this node and its children if it is one of the target nodes, or a live announcer.
+      // Also skip children of already hidden nodes, as aria-hidden is recursive. An exception is
+      // made for elements with role="row" since VoiceOver on iOS has issues hiding elements with role="row".
+      // For that case we want to hide the cells inside as well (https://bugs.webkit.org/show_bug.cgi?id=222623).
+      if (
+        visibleNodes.has(node) ||
+        (hiddenNodes.has(node.parentElement) && node.parentElement.getAttribute('role') !== 'row')
+      ) {
+        return NodeFilter.FILTER_REJECT;
+      }
 
-        // Skip this node but continue to children if one of the targets is inside the node.
-        for (let target of visibleNodes) {
-          if (node.contains(target)) {
-            return NodeFilter.FILTER_SKIP;
-          }
+      // Skip this node but continue to children if one of the targets is inside the node.
+      for (let target of visibleNodes) {
+        if (node.contains(target)) {
+          return NodeFilter.FILTER_SKIP;
         }
+      }
+
+      return NodeFilter.FILTER_ACCEPT;
+    };
+
+    let walker = document.createTreeWalker(
+      root,
+      NodeFilter.SHOW_ELEMENT,
+      {acceptNode}
+    );
 
-        return NodeFilter.FILTER_ACCEPT;
+    // TreeWalker does not include the root.
+    let acceptRoot = acceptNode(root);
+    if (acceptRoot === NodeFilter.FILTER_ACCEPT) {
+      hide(root);
+    }
+
+    if (acceptRoot !== NodeFilter.FILTER_REJECT) {
+      let node = walker.nextNode() as Element;
+      while (node != null) {
+        hide(node);
+        node = walker.nextNode() as Element;
       }
     }
-  );
+  };
 
   let hide = (node: Element) => {
     let refCount = refCountMap.get(node) ?? 0;
@@ -83,11 +99,7 @@ export function ariaHideOutside(targets: Element[], root = document.body) {
     observerStack[observerStack.length - 1].disconnect();
   }
 
-  let node = walker.nextNode() as Element;
-  while (node != null) {
-    hide(node);
-    node = walker.nextNode() as Element;
-  }
+  walk(root);
 
   let observer = new MutationObserver(changes => {
     for (let change of changes) {
@@ -98,6 +110,13 @@ export function ariaHideOutside(targets: Element[], root = document.body) {
       // If the parent element of the added nodes is not within one of the targets,
       // and not already inside a hidden node, hide all of the new children.
       if (![...visibleNodes, ...hiddenNodes].some(node => node.contains(change.target))) {
+        for (let node of change.removedNodes) {
+          if (node instanceof Element) {
+            visibleNodes.delete(node);
+            hiddenNodes.delete(node);
+          }
+        }
+
         for (let node of change.addedNodes) {
           if (
             (node instanceof HTMLElement || node instanceof SVGElement) &&
@@ -105,7 +124,7 @@ export function ariaHideOutside(targets: Element[], root = document.body) {
           ) {
             visibleNodes.add(node);
           } else if (node instanceof Element) {
-            hide(node);
+            walk(node);
           }
         }
       }
diff --git a/packages/@react-aria/overlays/test/ariaHideOutside.test.js b/packages/@react-aria/overlays/test/ariaHideOutside.test.js
index da6a3708b12..44434ba32fd 100644
--- a/packages/@react-aria/overlays/test/ariaHideOutside.test.js
+++ b/packages/@react-aria/overlays/test/ariaHideOutside.test.js
@@ -206,6 +206,36 @@ describe('ariaHideOutside', function () {
     expect(getAllByRole('checkbox')).toHaveLength(2);
   });
 
+  it('should handle when a new element is added along with a top layer element', async function () {
+    let Test = props => (
+      <>
+        <button>Button</button>
+        {props.show && <div>
+          <div role="alert" data-react-aria-top-layer="true">Top layer</div>
+          <input type="checkbox" />
+        </div>}
+      </>
+    );
+
+    let {getByRole, queryByRole, getAllByRole, rerender} = render(<Test />);
+
+    let button = getByRole('button');
+    expect(queryByRole('checkbox')).toBeNull();
+
+    let revert = ariaHideOutside([button]);
+
+    rerender(<Test show />);
+
+    // MutationObserver is async
+    await waitFor(() => queryByRole('checkbox') == null);
+    expect(queryByRole('button')).not.toBeNull();
+    expect(getByRole('alert')).toHaveTextContent('Top layer');
+
+    revert();
+
+    expect(getAllByRole('checkbox')).toHaveLength(1);
+  });
+
   it('should handle when a new element is added inside a target element', async function () {
     let Test = props => (
       <>
diff --git a/packages/@react-spectrum/toast/stories/Toast.stories.tsx b/packages/@react-spectrum/toast/stories/Toast.stories.tsx
index 6449c439664..5a49576b728 100644
--- a/packages/@react-spectrum/toast/stories/Toast.stories.tsx
+++ b/packages/@react-spectrum/toast/stories/Toast.stories.tsx
@@ -18,10 +18,11 @@ import {Content} from '@react-spectrum/view';
 import {Dialog, DialogTrigger} from '@react-spectrum/dialog';
 import {Flex} from '@react-spectrum/layout';
 import {Heading} from '@react-spectrum/text';
-import React, {useState} from 'react';
+import React, {SyntheticEvent, useEffect, useRef, useState} from 'react';
 import {SpectrumToastOptions} from '../src/ToastContainer';
 import {storiesOf} from '@storybook/react';
 import {ToastContainer, ToastQueue} from '../';
+import {useLandmark} from '@react-aria/landmark';
 
 storiesOf('Toast', module)
   .addParameters({
@@ -41,7 +42,9 @@ storiesOf('Toast', module)
   .addDecorator((story, {parameters}) => (
     <>
       {!parameters.disableToastContainer && <ToastContainer />}
-      {story()}
+      <MainLandmark>
+        {story()}
+      </MainLandmark>
     </>
   ))
   .add(
@@ -74,6 +77,10 @@ storiesOf('Toast', module)
   .add(
     'programmatically closing',
     args => <ToastToggle {...args} />
+  )
+  .add(
+    'with iframe',
+    () => <IframeExample />
   );
 
 function RenderProvider(options: SpectrumToastOptions) {
@@ -146,3 +153,99 @@ function MultipleInner() {
     </>
   );
 }
+
+function IframeExample() {
+  let onLoad = (e: SyntheticEvent) => {
+    let iframe = e.target as HTMLIFrameElement;
+    let window = iframe.contentWindow;
+    let document = window.document;
+
+    // Catch toasts inside the iframe and redirect them outside.
+    window.addEventListener('react-spectrum-toast', (e: CustomEvent) => {
+      e.preventDefault();
+      ToastQueue[e.detail.variant](e.detail.children, e.detail.options);
+    });
+
+    let prevFocusedElement = null;
+    window.addEventListener('react-aria-landmark-navigation', (e: CustomEvent) => {
+      e.preventDefault();
+      let el = document.activeElement;
+      if (el !== document.body) {
+        prevFocusedElement = el;
+      }
+
+      // Prevent focus scope from stealing focus back when we move focus to the iframe.
+      document.body.setAttribute('data-react-aria-top-layer', 'true');
+
+      window.parent.postMessage({
+        type: 'landmark-navigation',
+        direction: e.detail.direction
+      });
+
+      setTimeout(() => {
+        document.body.removeAttribute('data-react-aria-top-layer');
+      }, 100);
+    });
+
+    // When the iframe is re-focused, restore focus back inside where it was before.
+    window.addEventListener('focus', () => {
+      if (prevFocusedElement) {
+        prevFocusedElement.focus();
+        prevFocusedElement = null;
+      }
+    });
+
+    // Move focus to first or last landmark when we receive a message from the parent page.
+    window.addEventListener('message', e => {
+      if (e.data.type === 'landmark-navigation') {
+        document.body.dispatchEvent(new KeyboardEvent('keydown', {key: 'F6', shiftKey: e.data.direction === 'backward', bubbles: true}));
+      }
+    });
+  };
+
+  useEffect(() => {
+    let onMessage = (e: MessageEvent) => {
+      let iframe = ref.current;
+      if (e.data.type === 'landmark-navigation') {
+        // Move focus to the iframe so that when focus is restored there, and we can redirect it back inside (below).
+        iframe.focus();
+
+        // Now re-dispatch the keyboard event so landmark navigation outside the iframe picks it up.
+        iframe.dispatchEvent(new KeyboardEvent('keydown', {key: 'F6', shiftKey: e.data.direction === 'backward', bubbles: true}));
+      }
+    };
+
+    window.addEventListener('message', onMessage);
+    return () => window.removeEventListener('message', onMessage);
+  }, []);
+
+  let ref = useRef(null);
+  let {landmarkProps} = useLandmark({
+    role: 'main',
+    focus(direction) {
+      // when iframe landmark receives focus via landmark navigation, go to first/last landmark inside iframe.
+      ref.current.contentWindow.postMessage({
+        type: 'landmark-navigation',
+        direction
+      });
+    }
+  }, ref);
+
+  return (
+    <iframe
+      ref={ref}
+      {...landmarkProps}
+      title="iframe"
+      width="500"
+      height="500"
+      src="iframe.html?providerSwitcher-express=false&providerSwitcher-toastPosition=bottom&viewMode=story&id=toast--with-dialog"
+      onLoad={onLoad}
+      tabIndex={-1} />
+  );
+}
+
+function MainLandmark(props) {
+  let ref = useRef();
+  let {landmarkProps} = useLandmark({...props, role: 'main'}, ref);
+  return <main aria-label="Danni's unicorn corral" ref={ref} {...props} {...landmarkProps} style={{padding: 40, background: 'white'}}>{props.children}</main>;
+}