diff --git a/sdks/python/apache_beam/dataframe/frames.py b/sdks/python/apache_beam/dataframe/frames.py
index ccd01f35f87b..ce6db1a12057 100644
--- a/sdks/python/apache_beam/dataframe/frames.py
+++ b/sdks/python/apache_beam/dataframe/frames.py
@@ -4232,22 +4232,11 @@ def __getitem__(self, name):
         projection=name)
 
   @frame_base.with_docs_from(DataFrameGroupBy)
-  def agg(self, fn, *args, **kwargs):
-    if _is_associative(fn):
-      return _liftable_agg(fn)(self, *args, **kwargs)
-    elif _is_liftable_with_sum(fn):
-      return _liftable_agg(fn, postagg_meth='sum')(self, *args, **kwargs)
-    elif _is_unliftable(fn):
-      return _unliftable_agg(fn)(self, *args, **kwargs)
-    elif callable(fn):
-      return DeferredDataFrame(
-          expressions.ComputedExpression(
-              'agg',
-              lambda gb: gb.agg(fn, *args, **kwargs), [self._expr],
-              requires_partition_by=partitionings.Index(),
-              preserves_partition_by=partitionings.Singleton()))
+  def agg(self, fn=None, *args, **kwargs):
+    if fn is None:
+      return _agg_with_no_function(self, *args, **kwargs)
     else:
-      raise NotImplementedError(f"GroupBy.agg(func={fn!r})")
+      return _handle_agg_function(self, fn, "agg", *args, **kwargs)
 
   @property
   def ndim(self):
@@ -4696,6 +4685,82 @@ def _check_str_or_np_builtin(agg_func, func_list):
       getattr(agg_func, '__name__', None) in func_list
       and agg_func.__module__ in ('numpy', 'builtins'))
 
+def _agg_with_no_function(gb, *args, **kwargs):
+  """
+  Applies aggregation functions to the grouped data based on the provided
+  keyword arguments and combines the results into a single DataFrame.
+
+  Args:
+      gb: The groupby instance (DeferredGroupBy).
+      *args: Additional positional arguments passed to the aggregation funcs.
+      **kwargs: A dictionary where each key is the column name to aggregate,
+                the value is a tuple containing the input column name and
+                the aggregation function to apply.
+
+  Returns:
+      DeferredDataFrame: A DataFrame that contains the aggregated results of
+                          all specified columns.
+
+  Raises:
+      ValueError: If no aggregation functions are provided in the `kwargs`.
+      NotImplementedError: If the aggregation function type is unsupported.
+  """
+  if not kwargs:
+    raise ValueError("No aggregation functions specified")
+
+  # Handle dictionary-like input for aggregation.
+  result_columns, result_frames = [], []
+  for col_name, (input_col, agg_fn) in kwargs.items():
+    frame = _handle_agg_function(
+      gb[input_col], agg_fn, f"agg_{col_name}", *args
+    )
+    result_frames.append(frame)
+    result_columns.append(col_name)
+
+  # Combine all the resulting DeferredDataFrames into a single DataFrame.
+  return DeferredDataFrame(
+      expressions.ComputedExpression(
+          "agg",
+          lambda *results: pd.concat(results, axis=1, keys=result_columns),
+          [frame._expr for frame in result_frames],
+          requires_partition_by=partitionings.Index(),
+          preserves_partition_by=partitionings.Singleton(),
+      )
+  )
+
+def _handle_agg_function(gb, agg_func, agg_name, *args, **kwargs):
+  """
+  Handles the aggregation logic based on the function type passed.
+
+  Args:
+      gb: The groupby instance (DeferredGroupBy).
+      agg_name: The name/label of the aggregation function.
+      fn: The aggregation function to apply.
+      *args: Additional arguments to pass to the aggregation function.
+      **kwargs: Keyword arguments to pass to the aggregation function.
+
+  Returns:
+      A DeferredDataFrame or the result of the aggregation function.
+
+  Raises:
+      NotImplementedError: If the aggregation function type is unsupported.
+  """
+  if _is_associative(agg_func):
+    return _liftable_agg(agg_func)(gb, *args, **kwargs)
+  elif _is_liftable_with_sum(agg_func):
+    return _liftable_agg(agg_func, postagg_meth='sum')(gb, *args, **kwargs)
+  elif _is_unliftable(agg_func):
+    return _unliftable_agg(agg_func)(gb, *args, **kwargs)
+  elif callable(agg_func):
+    return DeferredDataFrame(
+        expressions.ComputedExpression(
+            agg_name,
+            lambda gb_val: gb_val.agg(agg_func, *args, **kwargs),
+            [gb._expr],
+            requires_partition_by=partitionings.Index(),
+            preserves_partition_by=partitionings.Singleton()))
+  else:
+    raise NotImplementedError(f"GroupBy.agg(func={agg_func!r})")
 
 def _is_associative(agg_func):
   return _check_str_or_np_builtin(agg_func, LIFTABLE_AGGREGATIONS)
diff --git a/sdks/python/apache_beam/dataframe/frames_test.py b/sdks/python/apache_beam/dataframe/frames_test.py
index bfe87dab52eb..27c62d2772ad 100644
--- a/sdks/python/apache_beam/dataframe/frames_test.py
+++ b/sdks/python/apache_beam/dataframe/frames_test.py
@@ -2364,6 +2364,16 @@ def test_std_all_na(self):
     self._run_test(lambda s: s.agg('std'), s)
     self._run_test(lambda s: s.std(), s)
 
+  def test_df_agg_operations_on_columns(self):
+    self._run_test(
+        lambda df: df.groupby('group').agg(
+            mean_foo=('foo', lambda x: np.mean(x)),
+            median_bar=('bar', lambda x: np.median(x)),
+            sum_baz=('baz', 'sum'),
+            count_bool=('bool', 'count'),
+        ),
+        GROUPBY_DF)
+
   def test_std_mostly_na_with_ddof(self):
     df = pd.DataFrame({
         'one': [i if i % 8 == 0 else np.nan for i in range(8)],