diff --git a/maven-model-builder/src/main/java/org/apache/maven/model/profile/DefaultProfileActivationContext.java b/maven-model-builder/src/main/java/org/apache/maven/model/profile/DefaultProfileActivationContext.java
index fa3ed33b5818..dda76e4255c6 100644
--- a/maven-model-builder/src/main/java/org/apache/maven/model/profile/DefaultProfileActivationContext.java
+++ b/maven-model-builder/src/main/java/org/apache/maven/model/profile/DefaultProfileActivationContext.java
@@ -24,6 +24,10 @@
 import java.util.Map;
 import java.util.Properties;
 
+import org.codehaus.plexus.interpolation.InterpolationException;
+import org.codehaus.plexus.interpolation.MapBasedValueSource;
+import org.codehaus.plexus.interpolation.RegexBasedInterpolator;
+
 import static java.util.stream.Collectors.collectingAndThen;
 import static java.util.stream.Collectors.toMap;
 
@@ -205,4 +209,13 @@ public DefaultProfileActivationContext setProjectProperties(Properties projectPr
 
         return this;
     }
+
+    @Override
+    public String interpolate(String value) throws InterpolationException {
+        RegexBasedInterpolator interpolator = new RegexBasedInterpolator();
+        interpolator.addValueSource(new MapBasedValueSource(userProperties));
+        interpolator.addValueSource(new MapBasedValueSource(projectProperties));
+        interpolator.addValueSource(new MapBasedValueSource(systemProperties));
+        return interpolator.interpolate(value);
+    }
 }
diff --git a/maven-model-builder/src/main/java/org/apache/maven/model/profile/ProfileActivationContext.java b/maven-model-builder/src/main/java/org/apache/maven/model/profile/ProfileActivationContext.java
index e4d48154973a..f1baf0b3523e 100644
--- a/maven-model-builder/src/main/java/org/apache/maven/model/profile/ProfileActivationContext.java
+++ b/maven-model-builder/src/main/java/org/apache/maven/model/profile/ProfileActivationContext.java
@@ -22,6 +22,8 @@
 import java.util.List;
 import java.util.Map;
 
+import org.codehaus.plexus.interpolation.InterpolationException;
+
 /**
  * Describes the environmental context used to determine the activation status of profiles.
  *
@@ -79,4 +81,11 @@ public interface ProfileActivationContext {
      * @return The project properties, never {@code null}.
      */
     Map<String, String> getProjectProperties();
+
+    /**
+     * Interpolates value from this context.
+     *
+     * @since 3.9.7
+     */
+    String interpolate(String value) throws InterpolationException;
 }
diff --git a/maven-model-builder/src/main/java/org/apache/maven/model/profile/activation/PropertyProfileActivator.java b/maven-model-builder/src/main/java/org/apache/maven/model/profile/activation/PropertyProfileActivator.java
index 8fff2563b752..03c9b1aa7ee5 100644
--- a/maven-model-builder/src/main/java/org/apache/maven/model/profile/activation/PropertyProfileActivator.java
+++ b/maven-model-builder/src/main/java/org/apache/maven/model/profile/activation/PropertyProfileActivator.java
@@ -29,6 +29,7 @@
 import org.apache.maven.model.building.ModelProblemCollector;
 import org.apache.maven.model.building.ModelProblemCollectorRequest;
 import org.apache.maven.model.profile.ProfileActivationContext;
+import org.codehaus.plexus.interpolation.InterpolationException;
 import org.codehaus.plexus.util.StringUtils;
 
 /**
@@ -82,6 +83,10 @@ public boolean isActive(Profile profile, ProfileActivationContext context, Model
                 reverseValue = true;
                 propValue = propValue.substring(1);
             }
+            propValue = interpolate(profile, property, propValue, context, problems);
+            if (propValue == null) {
+                return false;
+            }
 
             // we have a value, so it has to match the system value...
             boolean result = propValue.equals(sysValue);
@@ -109,4 +114,20 @@ public boolean presentInConfig(Profile profile, ProfileActivationContext context
         }
         return true;
     }
+
+    private String interpolate(
+            Profile profile,
+            ActivationProperty property,
+            String value,
+            ProfileActivationContext context,
+            ModelProblemCollector problems) {
+        try {
+            return context.interpolate(value);
+        } catch (InterpolationException e) {
+            problems.add(new ModelProblemCollectorRequest(Severity.ERROR, Version.BASE)
+                    .setMessage("The property value could not be interpolated in the profile " + profile.getId())
+                    .setLocation(property.getLocation("")));
+            return null;
+        }
+    }
 }
diff --git a/maven-model-builder/src/test/java/org/apache/maven/model/profile/activation/PropertyProfileActivatorTest.java b/maven-model-builder/src/test/java/org/apache/maven/model/profile/activation/PropertyProfileActivatorTest.java
index bc827bdb218b..16b228304b4d 100644
--- a/maven-model-builder/src/test/java/org/apache/maven/model/profile/activation/PropertyProfileActivatorTest.java
+++ b/maven-model-builder/src/test/java/org/apache/maven/model/profile/activation/PropertyProfileActivatorTest.java
@@ -155,4 +155,52 @@ public void testWithValue_UserPropertyDominantOverSystemProperty() throws Except
 
         assertActivation(false, profile, newContext(props2, props1));
     }
+
+    public void testWithValueInterpolation() throws Exception {
+        Profile profile = newProfile("prop", "${value}");
+        // prop => key
+        // ${value} => key
+
+        Properties userProperties = newProperties("prop", "key");
+        Properties systemProperties = newProperties("value", "key");
+
+        assertActivation(true, profile, newContext(userProperties, systemProperties));
+        assertActivation(false, profile, newContext(new Properties(), systemProperties));
+        assertActivation(false, profile, newContext(userProperties, new Properties()));
+    }
+
+    public void testWithValueInterpolationNegation() throws Exception {
+        Profile profile = newProfile("prop", "!${value}");
+        // prop => key
+        // ${value} => key
+
+        Properties userProperties = newProperties("prop", "key");
+        Properties systemProperties = newProperties("value", "key");
+
+        assertActivation(false, profile, newContext(userProperties, systemProperties));
+        assertActivation(true, profile, newContext(new Properties(), systemProperties));
+        assertActivation(true, profile, newContext(userProperties, new Properties()));
+    }
+
+    public void testWithValueInterpolationMismatch() throws Exception {
+        Profile profile = newProfile("prop", "${value}");
+        // prop => key
+        // ${value} => anotherKey
+
+        Properties userProperties = newProperties("prop", "key");
+        Properties systemProperties = newProperties("value", "anotherKey");
+
+        assertActivation(false, profile, newContext(userProperties, systemProperties));
+    }
+
+    public void testWithValueInterpolationMismatchNegation() throws Exception {
+        Profile profile = newProfile("prop", "!${value}");
+        // prop => key
+        // ${value} => anotherKey
+
+        Properties userProperties = newProperties("prop", "key");
+        Properties systemProperties = newProperties("value", "anotherKey");
+
+        assertActivation(true, profile, newContext(userProperties, systemProperties));
+    }
 }