diff --git a/python/tvm/topi/hexagon/slice_ops/__init__.py b/python/tvm/topi/hexagon/slice_ops/__init__.py
index b96156dc46d2..5f86e706af50 100644
--- a/python/tvm/topi/hexagon/slice_ops/__init__.py
+++ b/python/tvm/topi/hexagon/slice_ops/__init__.py
@@ -35,3 +35,4 @@
 from .relu import relu_compute, relu_stir_schedule
 from .tanh import tanh_te_compute, tanhf16_schedule
 from .dwconv2d import *
+from .depth_to_space import d2s_compute, d2s_schedule
diff --git a/python/tvm/topi/hexagon/slice_ops/depth_to_space.py b/python/tvm/topi/hexagon/slice_ops/depth_to_space.py
new file mode 100644
index 000000000000..aa14a97f5ee9
--- /dev/null
+++ b/python/tvm/topi/hexagon/slice_ops/depth_to_space.py
@@ -0,0 +1,43 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#   http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+
+""" Compute and schedule for depth to space slice op
+"""
+
+from tvm import te, tir, topi
+from ..utils import get_layout_transform_fn
+
+
+def d2s_compute(inp, block_size, layout, mode):
+    """depth_to_space compute"""
+    return topi.nn.depth_to_space(inp, block_size=block_size, layout=layout, mode=mode)
+
+
+def d2s_schedule(inp, out, input_layout, output_layout):
+    """Schedule for depth to space: top level function"""
+    if (input_layout != output_layout) or (
+        output_layout not in ("nhwc-8h2w32c2w-2d", "nhwc-8h8w32c-2d")
+    ):
+        raise RuntimeError(
+            f"Unexpected input_layout, output_layout '{input_layout, output_layout}'"
+        )
+    d2s_func = te.create_prim_func([inp, out])
+    sch = tir.Schedule(d2s_func, debug_mask="all")
+    compute = sch.get_block("depth_to_space")
+    sch.transform_layout(compute, inp.name, get_layout_transform_fn(input_layout))
+    sch.transform_layout(compute, out.name, get_layout_transform_fn(output_layout))
+    return sch
diff --git a/tests/python/contrib/test_hexagon/topi/test_depth_to_space.py b/tests/python/contrib/test_hexagon/topi/test_depth_to_space.py
new file mode 100644
index 000000000000..f74d13f641d5
--- /dev/null
+++ b/tests/python/contrib/test_hexagon/topi/test_depth_to_space.py
@@ -0,0 +1,136 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#   http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+# pylint: disable=line-too-long, redefined-outer-name
+
+"""Test depth_to_space slice op for hexagon"""
+
+import numpy as np
+import pytest
+
+import tvm
+from tvm import te
+import tvm.testing
+from tvm.topi.hexagon.slice_ops.depth_to_space import d2s_compute, d2s_schedule
+from tvm.topi.testing import depth_to_space_python
+
+from ..infrastructure import allocate_hexagon_array, transform_numpy
+
+
+d2s_fp16_tests = (
+    ((1, 8, 8, 256), 2, "CDR", "float16", "nhwc-8h2w32c2w-2d", "nhwc-8h2w32c2w-2d"),
+    ((1, 8, 8, 1024), 4, "CDR", "float16", "nhwc-8h2w32c2w-2d", "nhwc-8h2w32c2w-2d"),
+    ((1, 16, 16, 256), 2, "CDR", "float16", "nhwc-8h2w32c2w-2d", "nhwc-8h2w32c2w-2d"),
+    ((1, 16, 16, 1024), 4, "CDR", "float16", "nhwc-8h2w32c2w-2d", "nhwc-8h2w32c2w-2d"),
+    ((1, 8, 8, 256), 2, "DCR", "float16", "nhwc-8h2w32c2w-2d", "nhwc-8h2w32c2w-2d"),
+    ((1, 8, 8, 1024), 4, "DCR", "float16", "nhwc-8h2w32c2w-2d", "nhwc-8h2w32c2w-2d"),
+    ((1, 16, 16, 256), 2, "DCR", "float16", "nhwc-8h2w32c2w-2d", "nhwc-8h2w32c2w-2d"),
+    ((1, 16, 16, 1024), 4, "DCR", "float16", "nhwc-8h2w32c2w-2d", "nhwc-8h2w32c2w-2d"),
+)
+
+d2s_uint8_tests = (
+    ((1, 8, 8, 256), 2, "CDR", "uint8", "nhwc-8h8w32c-2d", "nhwc-8h8w32c-2d"),
+    ((1, 8, 8, 1024), 4, "CDR", "uint8", "nhwc-8h8w32c-2d", "nhwc-8h8w32c-2d"),
+    ((1, 8, 8, 256), 2, "DCR", "uint8", "nhwc-8h8w32c-2d", "nhwc-8h8w32c-2d"),
+    ((1, 8, 8, 1024), 4, "DCR", "uint8", "nhwc-8h8w32c-2d", "nhwc-8h8w32c-2d"),
+)
+
+
+class TestD2SSlice:
+    """Test class that defines the Depth to Space slice test"""
+
+    (input_shape, block_size, mode, dtype, input_layout, output_layout,) = tvm.testing.parameters(
+        *d2s_fp16_tests,
+        *d2s_uint8_tests,
+    )
+
+    working_scope = tvm.testing.parameter("global.vtcm")
+
+    @tvm.testing.fixture
+    def input_np(self, input_shape, dtype):
+        return np.random.uniform(size=input_shape).astype(dtype)
+
+    @tvm.testing.fixture
+    def transformed_input_np(self, input_np, input_layout):
+        return transform_numpy(input_np, "nhwc", input_layout)
+
+    @tvm.testing.fixture
+    def ref_output_np(self, input_np, block_size, mode):
+        a_np = np.transpose(input_np, axes=[0, 3, 1, 2])
+        ref_np = depth_to_space_python(a_np, block_size, mode=mode)
+        ref_np = np.transpose(ref_np, axes=[0, 2, 3, 1])
+        return ref_np
+
+    @tvm.testing.fixture
+    def transformed_ref_output_np(self, ref_output_np, output_layout):
+        return transform_numpy(ref_output_np, "nhwc", output_layout)
+
+    @tvm.testing.requires_hexagon
+    def test_d2s_slice(
+        self,
+        input_shape,
+        block_size,
+        mode,
+        dtype,
+        input_layout,
+        output_layout,
+        hexagon_session,
+        working_scope,
+        transformed_input_np,
+        transformed_ref_output_np,
+    ):
+        """Top level testing function for depth to space"""
+        Input = te.placeholder(input_shape, name="Input", dtype=dtype)
+
+        Output = d2s_compute(Input, block_size, "NHWC", mode)
+
+        target_hexagon = tvm.target.hexagon("v69")
+        target = tvm.target.Target(target_hexagon, host=target_hexagon)
+
+        tir_s = d2s_schedule(Input, Output, input_layout, output_layout)
+
+        input_data = allocate_hexagon_array(
+            hexagon_session.device,
+            data=transformed_input_np,
+            axis_separators=[4],
+            mem_scope=working_scope,
+        )
+        output_data = allocate_hexagon_array(
+            hexagon_session.device,
+            tensor_shape=transformed_ref_output_np.shape,
+            dtype=transformed_ref_output_np.dtype,
+            axis_separators=[4],
+            mem_scope=working_scope,
+        )
+        with tvm.transform.PassContext(opt_level=3):
+            runtime_module = tvm.build(
+                tir_s.mod, [Input, Output], target=target, name="depth_to_space"
+            )
+        mod = hexagon_session.load_module(runtime_module)
+
+        mod(input_data, output_data)
+        output_np = output_data.numpy()
+
+        tvm.testing.assert_allclose(
+            output_np,
+            transformed_ref_output_np,
+            1e-3,
+            1e-3,
+        )
+
+
+if __name__ == "__main__":
+    tvm.testing.main()