diff --git a/src/target/llvm/codegen_llvm.cc b/src/target/llvm/codegen_llvm.cc
index 5438aecd753e..ee5a6796c994 100644
--- a/src/target/llvm/codegen_llvm.cc
+++ b/src/target/llvm/codegen_llvm.cc
@@ -1387,6 +1387,9 @@ llvm::Value* CodeGenLLVM::CreateIntrinsic(const CallNode* op) {
              op->op.same_as(builtin::end_profile_intrinsic())) {
     LOG(INFO) << "Ignoring profile_intrinsic ... " << op->op;
     return nullptr;
+  } else if (op->op.same_as(builtin::assume())) {
+    llvm::Value* cond = MakeValue(op->args[0]);
+    return builder_->CreateAssumption(cond);
   } else {
     LOG(FATAL) << "unknown intrinsic " << op->op;
   }
diff --git a/tests/python/unittest/test_target_codegen_llvm.py b/tests/python/unittest/test_target_codegen_llvm.py
index bef682435ebf..44f950c82ad3 100644
--- a/tests/python/unittest/test_target_codegen_llvm.py
+++ b/tests/python/unittest/test_target_codegen_llvm.py
@@ -978,5 +978,29 @@ def test_llvm_target_attributes():
         assert n in functions_with_target
 
 
+@tvm.testing.requires_llvm
+def test_llvm_assume():
+    """
+    Check that LLVM does not error out when generating code with tir.assume.
+    Verifying for llvm.assume being generated is not easy as the intrinsic and its
+    related instructions get removed during optimizations
+    """
+
+    @T.prim_func
+    def tir_assume_func(A: T.Buffer((4, 4), "int32"), B: T.Buffer((14,), "int32")):
+        T.func_attr({"global_symbol": "main", "tir.noalias": True})
+        A_1 = T.Buffer((16,), "int32", data=A.data)
+        for axis0, axis1 in T.grid(4, 4):
+            T.assume(axis0 < 3 or axis1 < 2 or A_1[axis0 * 4 + axis1] == 0)
+        for i in range(14):
+            B_1 = T.Buffer((14,), "int32", data=B.data)
+            B_1[i] = A_1[i] * 2
+
+    mod = tvm.IRModule.from_expr(tir_assume_func)
+    inp = te.placeholder((4, 4), name="A", dtype="int32")
+    out = te.placeholder((14,), name="B", dtype="int32")
+    m = tvm.build(mod, [inp, out], target="llvm")
+
+
 if __name__ == "__main__":
     tvm.testing.main()