diff --git a/packages/db/src/collection/index.ts b/packages/db/src/collection/index.ts
index 5a4ab3c07..335d72473 100644
--- a/packages/db/src/collection/index.ts
+++ b/packages/db/src/collection/index.ts
@@ -2,6 +2,7 @@ import {
   CollectionRequiresConfigError,
   CollectionRequiresSyncConfigError,
 } from "../errors"
+import { lazyInitForCFWorkers } from "../utils/lazy-init-for-cf-workers"
 import { currentStateAsChanges } from "./change-events"
 
 import { CollectionStateManager } from "./state"
@@ -185,18 +186,37 @@ export function createCollection(
     utils?: UtilsRecord
   }
 ): Collection<any, string | number, UtilsRecord, any, any> {
-  const collection = new CollectionImpl<any, string | number, any, any, any>(
-    options
-  )
+  function _createCollection() {
+    const collection = new CollectionImpl<any, string | number, any, any, any>(
+      options
+    )
+
+    // Copy utils to both top level and .utils namespace
+    if (options.utils) {
+      collection.utils = { ...options.utils }
+    } else {
+      collection.utils = {}
+    }
+
+    return collection
+  }
+
+  // Check if we're running in Cloudflare Workers runtime
+  // https://developers.cloudflare.com/workers/runtime-apis/web-standards/#navigatoruseragent
+  const isCloudflareWorkers =
+    typeof navigator !== `undefined` &&
+    navigator.userAgent === `Cloudflare-Workers`
 
-  // Copy utils to both top level and .utils namespace
-  if (options.utils) {
-    collection.utils = { ...options.utils }
-  } else {
-    collection.utils = {}
+  // Workers runtime limitation
+  // Without this, initializing a collection causes this error:
+  //   Disallowed operation called within global scope.
+  if (isCloudflareWorkers) {
+    return lazyInitForCFWorkers(() => {
+      return _createCollection()
+    })
   }
 
-  return collection
+  return _createCollection()
 }
 
 export class CollectionImpl<
diff --git a/packages/db/src/utils/lazy-init-for-cf-workers.ts b/packages/db/src/utils/lazy-init-for-cf-workers.ts
new file mode 100644
index 000000000..fe8336c3d
--- /dev/null
+++ b/packages/db/src/utils/lazy-init-for-cf-workers.ts
@@ -0,0 +1,87 @@
+/**
+ * Wraps a factory function in a Proxy to defer initialization until first access.
+ * This prevents async operations (Like creating Tanstack DB Collections) from running in Cloudflare Workers' global scope.
+ *
+ * @param factory - A function that creates and returns the resource.
+ *                  Must be a callback to defer execution; passing the value directly
+ *                  would evaluate it at module load time, triggering the Cloudflare error.
+ * @returns A Proxy that lazily initializes the resource on first property access
+ *
+ * @example
+ * ```ts
+ * export const myCollection = lazyInitForCFWorkers(() =>
+ *   createCollection(queryCollectionOptions({
+ *     queryKey: ["myData"],
+ *     queryFn: async () => fetchData(),
+ *     // ... other options
+ *   }))
+ * );
+ * ```
+ */
+export function lazyInitForCFWorkers<T extends object>(factory: () => T): T {
+  // Closure: This variable is captured by getInstance() and the Proxy traps below.
+  // It remains in memory as long as the returned Proxy is referenced, enabling singleton behavior.
+  let instance: T | null = null
+
+  function getInstance() {
+    if (!instance) {
+      instance = factory()
+    }
+    return instance
+  }
+
+  return new Proxy({} as T, {
+    get(_target, prop, receiver) {
+      const inst = getInstance()
+      return Reflect.get(inst, prop, receiver)
+    },
+    set(_target, prop, value, receiver) {
+      const inst = getInstance()
+      return Reflect.set(inst, prop, value, receiver)
+    },
+    deleteProperty(_target, prop) {
+      const inst = getInstance()
+      return Reflect.deleteProperty(inst, prop)
+    },
+    has(_target, prop) {
+      const inst = getInstance()
+      return Reflect.has(inst, prop)
+    },
+    ownKeys(_target) {
+      const inst = getInstance()
+      return Reflect.ownKeys(inst)
+    },
+    getOwnPropertyDescriptor(_target, prop) {
+      const inst = getInstance()
+      return Reflect.getOwnPropertyDescriptor(inst, prop)
+    },
+    defineProperty(_target, prop, descriptor) {
+      const inst = getInstance()
+      return Reflect.defineProperty(inst, prop, descriptor)
+    },
+    getPrototypeOf(_target) {
+      const inst = getInstance()
+      return Reflect.getPrototypeOf(inst)
+    },
+    setPrototypeOf(_target, proto) {
+      const inst = getInstance()
+      return Reflect.setPrototypeOf(inst, proto)
+    },
+    isExtensible(_target) {
+      const inst = getInstance()
+      return Reflect.isExtensible(inst)
+    },
+    preventExtensions(_target) {
+      const inst = getInstance()
+      return Reflect.preventExtensions(inst)
+    },
+    apply(_target, thisArg, args) {
+      const inst = getInstance()
+      return Reflect.apply(inst as any, thisArg, args)
+    },
+    construct(_target, args, newTarget) {
+      const inst = getInstance()
+      return Reflect.construct(inst as any, args, newTarget)
+    },
+  })
+}