diff --git a/build-aux/m4/bitcoin_qt.m4 b/build-aux/m4/bitcoin_qt.m4
index 7de064e04bf1..edcb8deeee8e 100644
--- a/build-aux/m4/bitcoin_qt.m4
+++ b/build-aux/m4/bitcoin_qt.m4
@@ -108,11 +108,10 @@ AC_DEFUN([BITCOIN_QT_CONFIGURE],[
   BITCOIN_QT_CHECK([_BITCOIN_QT_FIND_LIBS])
 
   dnl This is ugly and complicated. Yuck. Works as follows:
-  dnl For Qt5, we can check a header to find out whether Qt is build
-  dnl statically. When Qt is built statically, some plugins must be linked into
-  dnl the final binary as well.
-  dnl _BITCOIN_QT_CHECK_STATIC_PLUGIN does a quick link-check and appends the
-  dnl results to QT_LIBS.
+  dnl We check a header to find out whether Qt is built statically.
+  dnl When Qt is built statically, some plugins must be linked into
+  dnl the final binary as well. _BITCOIN_QT_CHECK_STATIC_PLUGIN does
+  dnl a quick link-check and appends the results to QT_LIBS.
   BITCOIN_QT_CHECK([
   TEMP_CPPFLAGS=$CPPFLAGS
   TEMP_CXXFLAGS=$CXXFLAGS
@@ -150,7 +149,7 @@ AC_DEFUN([BITCOIN_QT_CONFIGURE],[
       AC_DEFINE(QT_QPA_PLATFORM_WINDOWS, 1, [Define this symbol if the qt platform is windows])
     elif test "x$TARGET_OS" = xlinux; then
       dnl workaround for https://bugreports.qt.io/browse/QTBUG-74874
-      AX_CHECK_LINK_FLAG([-lxcb-shm], [QT_LIBS="-lxcb-shm $QT_LIBS"], [AC_MSG_ERROR([could not link against -lxcb-shm])])
+      AX_CHECK_LINK_FLAG([-lxcb-shm], [QT_LIBS="$QT_LIBS -lxcb-shm"], [AC_MSG_ERROR([could not link against -lxcb-shm])])
       _BITCOIN_QT_CHECK_STATIC_PLUGIN([QXcbIntegrationPlugin], [-lqxcb])
       AC_DEFINE(QT_QPA_PLATFORM_XCB, 1, [Define this symbol if the qt platform is xcb])
     elif test "x$TARGET_OS" = xdarwin; then
@@ -162,7 +161,7 @@ AC_DEFUN([BITCOIN_QT_CONFIGURE],[
       _BITCOIN_QT_CHECK_STATIC_PLUGIN([QMacStylePlugin], [-lqmacstyle])
       AC_DEFINE(QT_QPA_PLATFORM_COCOA, 1, [Define this symbol if the qt platform is cocoa])
     elif test "x$TARGET_OS" = xandroid; then
-      QT_LIBS="-Wl,--export-dynamic,--undefined=JNI_OnLoad -lqtforandroid -ljnigraphics -landroid -lqtfreetype -lQt5EglSupport $QT_LIBS"
+      QT_LIBS="-Wl,--export-dynamic,--undefined=JNI_OnLoad -lqtforandroid -ljnigraphics -landroid -lqtfreetype $QT_LIBS"
       AC_DEFINE(QT_QPA_PLATFORM_ANDROID, 1, [Define this symbol if the qt platform is android])
     fi
   fi
@@ -171,7 +170,7 @@ AC_DEFUN([BITCOIN_QT_CONFIGURE],[
   ])
 
   if test "x$qt_bin_path" = x; then
-    qt_bin_path="`$PKG_CONFIG --variable=host_bins Qt5Core 2>/dev/null`"
+    qt_bin_path="`$PKG_CONFIG --variable=host_bins ${qt_lib_prefix}Core 2>/dev/null`"
   fi
 
   if test "x$use_hardening" != xno; then
@@ -301,12 +300,13 @@ AC_DEFUN([BITCOIN_QT_CONFIGURE],[
   AC_SUBST(MOC_DEFS)
 ])
 
-dnl All macros below are internal and should _not_ be used from the main
-dnl configure.ac.
-dnl ----
+dnl All macros below are internal and should _not_ be used from configure.ac.
 
-dnl Internal. Check if the linked version of Qt was built as static libs.
-dnl Requires: Qt5.
+dnl Internal. Check if the linked version of Qt was built statically.
+dnl
+dnl _BITCOIN_QT_IS_STATIC
+dnl ---------------------
+dnl
 dnl Requires: INCLUDES and LIBS must be populated as necessary.
 dnl Output: bitcoin_cv_static_qt=yes|no
 AC_DEFUN([_BITCOIN_QT_IS_STATIC],[
@@ -354,47 +354,54 @@ dnl
 dnl _BITCOIN_QT_CHECK_STATIC_LIBS
 dnl -----------------------------
 dnl
-dnl Inputs: no inputs.
 dnl Outputs: QT_LIBS is prepended.
 AC_DEFUN([_BITCOIN_QT_CHECK_STATIC_LIBS], [
-  PKG_CHECK_MODULES([QTFONTDATABASE], [Qt5FontDatabaseSupport${qt_lib_suffix}], [QT_LIBS="-lQt5FontDatabaseSupport${qt_lib_suffix} $QT_LIBS"])
-  PKG_CHECK_MODULES([QTEVENTDISPATCHER], [Qt5EventDispatcherSupport${qt_lib_suffix}], [QT_LIBS="-lQt5EventDispatcherSupport${qt_lib_suffix} $QT_LIBS"])
-  PKG_CHECK_MODULES([QTTHEME], [Qt5ThemeSupport${qt_lib_suffix}], [QT_LIBS="-lQt5ThemeSupport${qt_lib_suffix} $QT_LIBS"])
-  PKG_CHECK_MODULES([QTDEVICEDISCOVERY], [Qt5DeviceDiscoverySupport${qt_lib_suffix}], [QT_LIBS="-lQt5DeviceDiscoverySupport${qt_lib_suffix} $QT_LIBS"])
-  PKG_CHECK_MODULES([QTACCESSIBILITY], [Qt5AccessibilitySupport${qt_lib_suffix}], [QT_LIBS="-lQt5AccessibilitySupport${qt_lib_suffix} $QT_LIBS"])
-  PKG_CHECK_MODULES([QTFB], [Qt5FbSupport${qt_lib_suffix}], [QT_LIBS="-lQt5FbSupport${qt_lib_suffix} $QT_LIBS"])
+  PKG_CHECK_MODULES([QT_ACCESSIBILITY], [${qt_lib_prefix}AccessibilitySupport${qt_lib_suffix}], [QT_LIBS="$QT_ACCESSIBILITY_LIBS $QT_LIBS"])
+  PKG_CHECK_MODULES([QT_DEVICEDISCOVERY], [${qt_lib_prefix}DeviceDiscoverySupport${qt_lib_suffix}], [QT_LIBS="$QT_DEVICEDISCOVERY_LIBS $QT_LIBS"])
+  PKG_CHECK_MODULES([QT_EDID], [${qt_lib_prefix}EdidSupport${qt_lib_suffix}], [QT_LIBS="$QT_EDID_LIBS $QT_LIBS"])
+  PKG_CHECK_MODULES([QT_EVENTDISPATCHER], [${qt_lib_prefix}EventDispatcherSupport${qt_lib_suffix}], [QT_LIBS="$QT_EVENTDISPATCHER_LIBS $QT_LIBS"])
+  PKG_CHECK_MODULES([QT_FB], [${qt_lib_prefix}FbSupport${qt_lib_suffix}], [QT_LIBS="$QT_FB_LIBS $QT_LIBS"])
+  PKG_CHECK_MODULES([QT_FONTDATABASE], [${qt_lib_prefix}FontDatabaseSupport${qt_lib_suffix}], [QT_LIBS="$QT_FONTDATABASE_LIBS $QT_LIBS"])
+  PKG_CHECK_MODULES([QT_THEME], [${qt_lib_prefix}ThemeSupport${qt_lib_suffix}], [QT_LIBS="$QT_THEME_LIBS $QT_LIBS"])
   if test "x$TARGET_OS" = xlinux; then
-    PKG_CHECK_MODULES([QTXCBQPA], [Qt5XcbQpa], [QT_LIBS="$QTXCBQPA_LIBS $QT_LIBS"])
+    PKG_CHECK_MODULES([QT_INPUT], [${qt_lib_prefix}InputSupport], [QT_LIBS="$QT_INPUT_LIBS $QT_LIBS"])
+    PKG_CHECK_MODULES([QT_SERVICE], [${qt_lib_prefix}ServiceSupport], [QT_LIBS="$QT_SERVICE_LIBS $QT_LIBS"])
+    PKG_CHECK_MODULES([QT_XCBQPA], [${qt_lib_prefix}XcbQpa], [QT_LIBS="$QT_XCBQPA_LIBS $QT_LIBS"])
   elif test "x$TARGET_OS" = xdarwin; then
-    PKG_CHECK_MODULES([QTCLIPBOARD], [Qt5ClipboardSupport${qt_lib_suffix}], [QT_LIBS="-lQt5ClipboardSupport${qt_lib_suffix} $QT_LIBS"])
-    PKG_CHECK_MODULES([QTGRAPHICS], [Qt5GraphicsSupport${qt_lib_suffix}], [QT_LIBS="-lQt5GraphicsSupport${qt_lib_suffix} $QT_LIBS"])
+    PKG_CHECK_MODULES([QT_CLIPBOARD], [${qt_lib_prefix}ClipboardSupport${qt_lib_suffix}], [QT_LIBS="$QT_CLIPBOARD_LIBS $QT_LIBS"])
+    PKG_CHECK_MODULES([QT_GRAPHICS], [${qt_lib_prefix}GraphicsSupport${qt_lib_suffix}], [QT_LIBS="$QT_GRAPHICS_LIBS $QT_LIBS"])
+    PKG_CHECK_MODULES([QT_SERVICE], [${qt_lib_prefix}ServiceSupport${qt_lib_suffix}], [QT_LIBS="$QT_SERVICE_LIBS $QT_LIBS"])
   elif test "x$TARGET_OS" = xwindows; then
-    PKG_CHECK_MODULES([QTWINDOWSUIAUTOMATION], [Qt5WindowsUIAutomationSupport${qt_lib_suffix}], [QT_LIBS="-lQt5WindowsUIAutomationSupport${qt_lib_suffix} $QT_LIBS"])
+    PKG_CHECK_MODULES([QT_WINDOWSUIAUTOMATION], [${qt_lib_prefix}WindowsUIAutomationSupport${qt_lib_suffix}], [QT_LIBS="$QT_WINDOWSUIAUTOMATION_LIBS $QT_LIBS"])
+  elif test "x$TARGET_OS" = xandroid; then
+    PKG_CHECK_MODULES([QT_EGL], [${qt_lib_prefix}EglSupport], [QT_LIBS="$QT_EGL_LIBS $QT_LIBS"])
   fi
 ])
 
 dnl Internal. Find Qt libraries using pkg-config.
+dnl
+dnl _BITCOIN_QT_FIND_LIBS
+dnl ---------------------
+dnl
 dnl Outputs: All necessary QT_* variables are set.
 dnl Outputs: have_qt_test and have_qt_dbus are set (if applicable) to yes|no.
 AC_DEFUN([_BITCOIN_QT_FIND_LIBS],[
   BITCOIN_QT_CHECK([
-    PKG_CHECK_MODULES([QT_CORE], [${qt_lib_prefix}Core${qt_lib_suffix} $qt_version], [],
+    PKG_CHECK_MODULES([QT_CORE], [${qt_lib_prefix}Core${qt_lib_suffix} $qt_version], [QT_INCLUDES="$QT_CORE_CFLAGS $QT_INCLUDES" QT_LIBS="$QT_CORE_LIBS $QT_LIBS"],
                       [BITCOIN_QT_FAIL([${qt_lib_prefix}Core${qt_lib_suffix} $qt_version not found])])
   ])
   BITCOIN_QT_CHECK([
-    PKG_CHECK_MODULES([QT_GUI], [${qt_lib_prefix}Gui${qt_lib_suffix} $qt_version], [],
+    PKG_CHECK_MODULES([QT_GUI], [${qt_lib_prefix}Gui${qt_lib_suffix} $qt_version], [QT_INCLUDES="$QT_GUI_CFLAGS $QT_INCLUDES" QT_LIBS="$QT_GUI_LIBS $QT_LIBS"],
                       [BITCOIN_QT_FAIL([${qt_lib_prefix}Gui${qt_lib_suffix} $qt_version not found])])
   ])
   BITCOIN_QT_CHECK([
-    PKG_CHECK_MODULES([QT_WIDGETS], [${qt_lib_prefix}Widgets${qt_lib_suffix} $qt_version], [],
+    PKG_CHECK_MODULES([QT_WIDGETS], [${qt_lib_prefix}Widgets${qt_lib_suffix} $qt_version], [QT_INCLUDES="$QT_WIDGETS_CFLAGS $QT_INCLUDES" QT_LIBS="$QT_WIDGETS_LIBS $QT_LIBS"],
                       [BITCOIN_QT_FAIL([${qt_lib_prefix}Widgets${qt_lib_suffix} $qt_version not found])])
   ])
   BITCOIN_QT_CHECK([
-    PKG_CHECK_MODULES([QT_NETWORK], [${qt_lib_prefix}Network${qt_lib_suffix} $qt_version], [],
+    PKG_CHECK_MODULES([QT_NETWORK], [${qt_lib_prefix}Network${qt_lib_suffix} $qt_version], [QT_INCLUDES="$QT_NETWORK_CFLAGS $QT_INCLUDES" QT_LIBS="$QT_NETWORK_LIBS $QT_LIBS"],
                       [BITCOIN_QT_FAIL([${qt_lib_prefix}Network${qt_lib_suffix} $qt_version not found])])
   ])
-  QT_INCLUDES="$QT_CORE_CFLAGS $QT_GUI_CFLAGS $QT_WIDGETS_CFLAGS $QT_NETWORK_CFLAGS"
-  QT_LIBS="$QT_CORE_LIBS $QT_GUI_LIBS $QT_WIDGETS_LIBS $QT_NETWORK_LIBS"
 
   BITCOIN_QT_CHECK([
     PKG_CHECK_MODULES([QT_TEST], [${qt_lib_prefix}Test${qt_lib_suffix} $qt_version], [QT_TEST_INCLUDES="$QT_TEST_CFLAGS"; have_qt_test=yes], [have_qt_test=no])
diff --git a/configure.ac b/configure.ac
index e5b43a767371..0e0e61a926b3 100644
--- a/configure.ac
+++ b/configure.ac
@@ -798,9 +798,6 @@ if test x$use_lcov_branch != xno; then
   AC_SUBST(LCOV_OPTS, "$LCOV_OPTS --rc lcov_branch_coverage=1")
 fi
 
-dnl Check for __int128
-AC_CHECK_TYPES([__int128])
-
 dnl Check for endianness
 AC_C_BIGENDIAN
 
diff --git a/depends/packages/qt.mk b/depends/packages/qt.mk
index ca191130a8a9..5a4b70b07bf0 100644
--- a/depends/packages/qt.mk
+++ b/depends/packages/qt.mk
@@ -147,6 +147,9 @@ $(package)_config_opts_riscv64_linux = -platform linux-g++ -xplatform bitcoin-li
 $(package)_config_opts_mingw32 = -no-opengl
 $(package)_config_opts_mingw32 += -no-dbus
 $(package)_config_opts_mingw32 += -xplatform win32-g++
+$(package)_config_opts_mingw32 += "QMAKE_CFLAGS = '$($(package)_cflags) $($(package)_cppflags)'"
+$(package)_config_opts_mingw32 += "QMAKE_CXXFLAGS = '$($(package)_cflags) $($(package)_cppflags)'"
+$(package)_config_opts_mingw32 += "QMAKE_LFLAGS = '$($(package)_ldflags)'"
 $(package)_config_opts_mingw32 += -device-option CROSS_COMPILE="$(host)-"
 $(package)_config_opts_mingw32 += -pch
 
@@ -236,9 +239,6 @@ define $(package)_preprocess_cmds
   echo "!host_build: QMAKE_CFLAGS     += $($(package)_cflags) $($(package)_cppflags)" >> qtbase/mkspecs/common/gcc-base.conf && \
   echo "!host_build: QMAKE_CXXFLAGS   += $($(package)_cxxflags) $($(package)_cppflags)" >> qtbase/mkspecs/common/gcc-base.conf && \
   echo "!host_build: QMAKE_LFLAGS     += $($(package)_ldflags)" >> qtbase/mkspecs/common/gcc-base.conf && \
-  sed -i.old "s|QMAKE_CFLAGS           += |!host_build: QMAKE_CFLAGS            = $($(package)_cflags) $($(package)_cppflags) |" qtbase/mkspecs/win32-g++/qmake.conf && \
-  sed -i.old "s|QMAKE_CXXFLAGS         += |!host_build: QMAKE_CXXFLAGS            = $($(package)_cxxflags) $($(package)_cppflags) |" qtbase/mkspecs/win32-g++/qmake.conf && \
-  sed -i.old "0,/^QMAKE_LFLAGS_/s|^QMAKE_LFLAGS_|!host_build: QMAKE_LFLAGS            = $($(package)_ldflags)\n&|" qtbase/mkspecs/win32-g++/qmake.conf && \
   sed -i.old "s|QMAKE_CC                = \$$$$\$$$${CROSS_COMPILE}clang|QMAKE_CC                = $($(package)_cc)|" qtbase/mkspecs/common/clang.conf && \
   sed -i.old "s|QMAKE_CXX               = \$$$$\$$$${CROSS_COMPILE}clang++|QMAKE_CXX               = $($(package)_cxx)|" qtbase/mkspecs/common/clang.conf && \
   sed -i.old "s/error(\"failed to parse default search paths from compiler output\")/\!darwin: error(\"failed to parse default search paths from compiler output\")/g" qtbase/mkspecs/features/toolchain.prf
diff --git a/src/crypto/muhash.h b/src/crypto/muhash.h
index 64a922086272..aee517c01895 100644
--- a/src/crypto/muhash.h
+++ b/src/crypto/muhash.h
@@ -24,7 +24,7 @@ class Num3072
 public:
     static constexpr size_t BYTE_SIZE = 384;
 
-#ifdef HAVE___INT128
+#ifdef __SIZEOF_INT128__
     typedef unsigned __int128 double_limb_t;
     typedef uint64_t limb_t;
     static constexpr int LIMBS = 48;