diff --git a/.azure/pipelines/helix-matrix.yml b/.azure/pipelines/helix-matrix.yml
index bf34bfd8e01f..9a6abda53f56 100644
--- a/.azure/pipelines/helix-matrix.yml
+++ b/.azure/pipelines/helix-matrix.yml
@@ -1,5 +1,9 @@
 # We only want to run full helix matrix on main
-pr: none
+pr:
+  autoCancel: true
+  branches:
+    include:
+    - '*'
 trigger: none
 schedules:
 # Cron timezone is UTC.
@@ -48,3 +52,41 @@ jobs:
     - name: Helix_logs
       path: artifacts/log/
       publishOnError: true
+      
+# Helix ARM64
+- ${{ if ne(variables['System.TeamProject'], 'internal') }}:
+  - template: jobs/default-build.yml
+    parameters:
+      jobName: Helix_matrix_arm64
+      jobDisplayName: "Tests: Helix ARM64 matrix"
+      agentOs: Windows
+      timeoutInMinutes: 480
+      steps:
+      - script: ./eng/build.cmd
+                -ci
+                -arch x64
+                -pack
+                -all
+        displayName: Build x64/arm64      
+      # Build the arm64 shared framework
+      - script: ./eng/build.cmd
+                -ci
+                -arch arm64
+                -pack
+                -noBuildJava
+                -noBuildNative
+                /p:OnlyPackPlatformSpecificPackages=true
+        displayName: Build ARM64 shared fx
+      - script: .\eng\build.cmd -ci -arch arm64 -noBuildRepoTasks -NoRestore -test -all
+                -projects eng\helix\helix.proj /p:IsHelixWindowsArmCheck=true
+                /p:IsHelixJob=true  /p:RunTemplateTests=true
+                /p:CrossgenOutput=false /p:ASPNETCORE_TEST_LOG_DIR=artifacts/log
+        displayName: Run build.cmd helix target
+        env:
+          HelixApiAccessToken: $(HelixApiAccessToken) # Needed for internal queues
+          SYSTEM_ACCESSTOKEN: $(System.AccessToken) # We need to set this env var to publish helix results to Azure Dev Ops
+      artifacts:
+      - name: Helix_arm64_logs
+        path: artifacts/log/
+        publishOnError: true
+        includeForks: true
diff --git a/eng/targets/Helix.Common.props b/eng/targets/Helix.Common.props
index 821967b2d727..5c185c59e802 100644
--- a/eng/targets/Helix.Common.props
+++ b/eng/targets/Helix.Common.props
@@ -33,6 +33,12 @@
         <HelixAvailableTargetQueue Include="Windows.Amd64.Server2022.Open" Platform="Windows" />
       </ItemGroup>
     </When>
+    <When Condition=" '$(IsHelixWindowsArmCheck)' == 'true' ">
+      <ItemGroup>
+        <!-- aspnetcore-helix-matrix[-internal] (helix-matrix.yml) arm64 job -->
+        <HelixAvailableTargetQueue Include="Windows.10.Arm64v8.Open" Platform="Windows" />
+      </ItemGroup>
+    </When>
     <Otherwise>
       <!-- aspnetcore-helix-matrix[-internal] (helix-matrix.yml) and RunHelix.ps1 -->
       <!-- aspnetcore-quarantined-tests (quarantined-tests.yml) and RunHelix.ps1 -RunQuarantinedTests -->
@@ -54,10 +60,6 @@
         <!-- Windows -->
         <HelixAvailableTargetQueue Include="Windows.10.Amd64.Server20H2.Open" Platform="Windows" />
         <HelixAvailableTargetQueue Include="Windows.Amd64.Server2022.Open" Platform="Windows" />
-
-        <!-- IIS Express isn't supported on arm64 and most of the IsWindowsOnlyTests depend on its setup scripts. -->
-        <HelixAvailableTargetQueue Include="Windows.10.Arm64v8.Open" Platform="Windows"
-            Condition=" '$(IsWindowsOnlyTest)' != 'true' "/>
       </ItemGroup>
     </Otherwise>
   </Choose>