diff --git a/.azure/pipelines/components-e2e-tests.yml b/.azure/pipelines/components-e2e-tests.yml
index d6e75be1a891..4c9915859442 100644
--- a/.azure/pipelines/components-e2e-tests.yml
+++ b/.azure/pipelines/components-e2e-tests.yml
@@ -49,10 +49,99 @@ variables:
 - template: /eng/common/templates/variables/pool-providers.yml
 
 jobs:
+# CoreCLR runtime E2E tests (UseMonoRuntime=false) — runs first for faster feedback
+# Threading tests are excluded via the csproj when UseMonoRuntime=false
+- template: jobs/default-build.yml
+  parameters:
+    jobName: Components_E2E_Test_CoreCLR
+    jobDisplayName: "Test: Blazor E2E tests on Linux (CoreCLR)"
+    agentOs: Linux
+    use1ESUbuntu: true
+    isAzDOTestingJob: true
+    enablePublishTestResults: false
+    timeoutInMinutes: 120
+    steps:
+    - script: git submodule update --init
+      displayName: Update submodules
+    - script: ./restore.sh
+      displayName: Run restore.sh
+    - script: npm ci
+      displayName: NPM install
+    - script: npm run build
+      displayName: Build JS
+    - script: .dotnet/dotnet build ./src/Components/test/E2ETest -c $(BuildConfiguration) /p:UseMonoRuntime=false
+      displayName: Build (CoreCLR)
+    - script: |
+        set -eo pipefail
+
+        .dotnet/dotnet test ./src/Components/test/E2ETest \
+          -c $(BuildConfiguration) \
+          --no-build \
+          /p:UseMonoRuntime=false \
+          --filter 'Quarantined!=true|Quarantined=false' \
+          -p:VsTestUseMSBuildOutput=false \
+          --logger:"trx%3BLogFileName=Microsoft.AspNetCore.Components.E2ETests.trx" \
+          --logger:"html%3BLogFileName=Microsoft.AspNetCore.Components.E2ETests.html" \
+          --results-directory $(Build.SourcesDirectory)/artifacts/TestResults/$(BuildConfiguration)/Unquarantined \
+          | tee e2e-test-output.log
+
+        if grep -q "No test matches the given testcase filter" e2e-test-output.log
+        then
+          echo "##vso[task.logissue type=error] No tests matched the filter."
+
+          exit 1
+        fi
+
+        # Check total tests run to detect abnormalities.
+        # Lower than Mono threshold since server-only tests (ServerExecutionTests, ServerRenderingTests) are excluded.
+        total=$(sed -nE 's/.*Failed:[[:space:]]*[0-9]+,[[:space:]]*Passed:[[:space:]]*[0-9]+,[[:space:]]*Skipped:[[:space:]]*[0-9]+,[[:space:]]*Total:[[:space:]]*([0-9]+).*/\1/p' e2e-test-output.log)
+        min_total=500
+        if [ -z "$total" ] || [ "$total" -lt "$min_total" ]
+        then
+          echo "##vso[task.logissue type=error] Insufficient total test count: $total. We expect at least $min_total tests to run."
+          exit 1
+        fi
+      displayName: Run E2E tests (CoreCLR)
+    - script: .dotnet/dotnet test ./src/Components/test/E2ETest -c $(BuildConfiguration) --no-build /p:UseMonoRuntime=false --filter 'Quarantined=true' -p:RunQuarantinedTests=true
+                 -p:VsTestUseMSBuildOutput=false
+                 --logger:"trx%3BLogFileName=Microsoft.AspNetCore.Components.E2ETests.trx"
+                 --logger:"html%3BLogFileName=Microsoft.AspNetCore.Components.E2ETests.html"
+                 --results-directory $(Build.SourcesDirectory)/artifacts/TestResults/$(BuildConfiguration)/Quarantined
+      displayName: Run Quarantined E2E tests (CoreCLR)
+      continueOnError: true
+    - task: PublishTestResults@2
+      displayName: Publish E2E Test Results (CoreCLR)
+      inputs:
+        testResultsFormat: 'VSTest'
+        testResultsFiles: '*.trx'
+        searchFolder: '$(Build.SourcesDirectory)/artifacts/TestResults/$(BuildConfiguration)/Unquarantined'
+        testRunTitle: ComponentsE2E-CoreCLR-$(AgentOsName)-$(BuildConfiguration)-xunit
+      condition: always()
+    - task: PublishTestResults@2
+      displayName: Publish Quarantined E2E Test Results (CoreCLR)
+      inputs:
+        testResultsFormat: 'VSTest'
+        testResultsFiles: '*.trx'
+        searchFolder: '$(Build.SourcesDirectory)/artifacts/TestResults/$(BuildConfiguration)/Quarantined'
+        testRunTitle: Quarantine-CoreCLR-$(AgentOsName)-$(BuildConfiguration)-xunit
+        mergeTestResults: true
+      condition: always()
+
+    artifacts:
+    - name: Components_E2E_CoreCLR_Logs
+      path: artifacts/log/
+      publishOnError: true
+      includeForks: true
+    - name: Components_E2E_CoreCLR_Test_Logs
+      path: '$(Build.SourcesDirectory)/artifacts/TestResults/$(BuildConfiguration)'
+      includeForks: true
+      publishOnError: true
+
+# Mono runtime (default) E2E tests
 - template: jobs/default-build.yml
   parameters:
     jobName: Components_E2E_Test
-    jobDisplayName: "Test: Blazor E2E tests on Linux"
+    jobDisplayName: "Test: Blazor E2E tests on Linux (Mono)"
     agentOs: Linux
     use1ESUbuntu: true
     isAzDOTestingJob: true
@@ -121,7 +210,7 @@ jobs:
         testResultsFormat: 'VSTest'
         testResultsFiles: '*.trx'
         searchFolder: '$(Build.SourcesDirectory)/artifacts/TestResults/$(BuildConfiguration)/Unquarantined'
-        testRunTitle: ComponentsE2E-$(AgentOsName)-$(BuildConfiguration)-xunit
+        testRunTitle: ComponentsE2E-Mono-$(AgentOsName)-$(BuildConfiguration)-xunit
       condition: always()
     - task: PublishTestResults@2
       displayName: Publish Quarantined E2E Test Results
@@ -129,7 +218,7 @@ jobs:
         testResultsFormat: 'VSTest'
         testResultsFiles: '*.trx'
         searchFolder: '$(Build.SourcesDirectory)/artifacts/TestResults/$(BuildConfiguration)/Quarantined'
-        testRunTitle: Quarantine-$(AgentOsName)-$(BuildConfiguration)-xunit
+        testRunTitle: Quarantine-Mono-$(AgentOsName)-$(BuildConfiguration)-xunit
         mergeTestResults: true
       condition: always()
 
diff --git a/src/Components/test/E2ETest/Microsoft.AspNetCore.Components.E2ETests.csproj b/src/Components/test/E2ETest/Microsoft.AspNetCore.Components.E2ETests.csproj
index 48c04184707e..a1edc88a05cb 100644
--- a/src/Components/test/E2ETest/Microsoft.AspNetCore.Components.E2ETests.csproj
+++ b/src/Components/test/E2ETest/Microsoft.AspNetCore.Components.E2ETests.csproj
@@ -42,6 +42,16 @@
     <Compile Include="$(SharedSourceRoot)Process\**\*.cs" LinkBase="Shared" />
   </ItemGroup>
 
+  <!-- Exclude threading test files when building with CoreCLR (UseMonoRuntime=false) since ThreadingApp requires Mono -->
+  <!-- Also exclude server-only tests since the CoreCLR job targets the WASM runtime path;
+       server-side Blazor already runs on CoreCLR by default and is covered by the Mono job. -->
+  <ItemGroup Condition="'$(UseMonoRuntime)' == 'false'">
+    <Compile Remove="Tests\ThreadingAppTest.cs" />
+    <Compile Remove="Tests\ThreadingAppHostedTest.cs" />
+    <Compile Remove="ServerExecutionTests\**\*.cs" />
+    <Compile Remove="ServerRenderingTests\**\*.cs" />
+  </ItemGroup>
+
   <ItemGroup>
     <Reference Include="Microsoft.AspNetCore" />
     <Reference Include="Microsoft.AspNetCore.Authentication.Core" />
@@ -74,13 +84,14 @@
     <ProjectReference Include="..\testassets\Components.TestServer\Components.TestServer.csproj" />
     <ProjectReference Include="..\..\WebAssembly\testassets\HostedInAspNet.Client\HostedInAspNet.Client.csproj" />
     <ProjectReference Include="..\..\WebAssembly\testassets\HostedInAspNet.Server\HostedInAspNet.Server.csproj" />
-    <ProjectReference Include="..\..\WebAssembly\testassets\ThreadingApp.Server\ThreadingApp.Server.csproj" />
+    <!-- Threading requires Mono; exclude when building with CoreCLR (UseMonoRuntime=false) -->
+    <ProjectReference Include="..\..\WebAssembly\testassets\ThreadingApp.Server\ThreadingApp.Server.csproj" Condition="'$(UseMonoRuntime)' != 'false'" />
   </ItemGroup>
 
   <ItemGroup Condition="'$(TestTrimmedOrMultithreadingApps)' != 'true'">
     <ProjectReference Include="..\..\benchmarkapps\Wasm.Performance\TestApp\Wasm.Performance.TestApp.csproj" />
     <ProjectReference Include="..\..\WebAssembly\testassets\StandaloneApp\StandaloneApp.csproj" />
-    <ProjectReference Include="..\..\WebAssembly\testassets\ThreadingApp\ThreadingApp.csproj" />
+    <ProjectReference Include="..\..\WebAssembly\testassets\ThreadingApp\ThreadingApp.csproj" Condition="'$(UseMonoRuntime)' != 'false'" />
     <ProjectReference Include="..\testassets\BasicTestApp\BasicTestApp.csproj" />
     <ProjectReference Include="..\testassets\GlobalizationWasmApp\GlobalizationWasmApp.csproj" />
     <ProjectReference Include="..\..\WebAssembly\testassets\Wasm.Prerendered.Server\Wasm.Prerendered.Server.csproj" />
@@ -97,7 +108,7 @@
 
     <ProjectReference Include="..\..\WebAssembly\testassets\Wasm.Prerendered.Server\Wasm.Prerendered.Server.csproj" Targets="Build;Publish" Properties="BuildProjectReferences=false;TestTrimmedOrMultithreadingApps=true;PublishDir=$(MSBuildThisFileDirectory)$(OutputPath)trimmed-or-threading\Wasm.Prerendered.Server\;" />
 
-    <ProjectReference Include="..\..\WebAssembly\testassets\ThreadingApp\ThreadingApp.csproj" Targets="Build;Publish" Properties="BuildProjectReferences=false;TestTrimmedOrMultithreadingApps=false;PublishDir=$(MSBuildThisFileDirectory)$(OutputPath)trimmed-or-threading\ThreadingApp\;" />
+    <ProjectReference Include="..\..\WebAssembly\testassets\ThreadingApp\ThreadingApp.csproj" Condition="'$(UseMonoRuntime)' != 'false'" Targets="Build;Publish" Properties="BuildProjectReferences=false;TestTrimmedOrMultithreadingApps=false;PublishDir=$(MSBuildThisFileDirectory)$(OutputPath)trimmed-or-threading\ThreadingApp\;" />
 
     <ProjectReference Include="..\testassets\Components.TestServer\Components.TestServer.csproj" Targets="Build;Publish" Properties="BuildProjectReferences=false;TestTrimmedOrMultithreadingApps=true;_SkipReferencedProjectPublishAssets=true;PublishDir=$(MSBuildThisFileDirectory)$(OutputPath)trimmed-or-threading\Components.TestServer\;" />
   </ItemGroup>