diff --git a/src/coreclr/nativeaot/BuildIntegration/Microsoft.DotNet.ILCompiler.SingleEntry.targets b/src/coreclr/nativeaot/BuildIntegration/Microsoft.DotNet.ILCompiler.SingleEntry.targets
index c2627502f9ddd6..059d1754c68263 100644
--- a/src/coreclr/nativeaot/BuildIntegration/Microsoft.DotNet.ILCompiler.SingleEntry.targets
+++ b/src/coreclr/nativeaot/BuildIntegration/Microsoft.DotNet.ILCompiler.SingleEntry.targets
@@ -24,6 +24,8 @@
     <_hostPackageName Condition="'$(_targetsNonPortableSdkRid)' == 'true'">runtime.$(RuntimeIdentifier).Microsoft.DotNet.ILCompiler</_hostPackageName>
     <_targetPackageName>runtime.$(_originalTargetOS)-$(_targetArchitecture).Microsoft.DotNet.ILCompiler</_targetPackageName>
     <_targetPackageName Condition="'$(_targetsNonPortableSdkRid)' == 'true'">runtime.$(RuntimeIdentifier).Microsoft.DotNet.ILCompiler</_targetPackageName>
+    <_targetRuntimePackName>Microsoft.NETCore.App.Runtime.NativeAOT.$(_originalTargetOS)-$(_targetArchitecture)</_targetRuntimePackName>
+    <_targetRuntimePackName Condition="'$(_targetsNonPortableSdkRid)' == 'true'">Microsoft.NETCore.App.Runtime.NativeAOT.$(RuntimeIdentifier)</_targetRuntimePackName>
 
     <!-- Treat linux-musl and linux-bionic etc. as linux -->
     <_targetOS>$(_originalTargetOS)</_targetOS>
@@ -64,8 +66,10 @@
 
     <PropertyGroup>
       <IlcHostPackagePath Condition="'@(ResolvedILCompilerPack)' == '$(_hostPackageName)'">@(ResolvedILCompilerPack->'%(PackageDirectory)')</IlcHostPackagePath>
-      <RuntimePackagePath Condition="'@(ResolvedTargetILCompilerPack)' == '$(_targetPackageName)'">@(ResolvedTargetILCompilerPack->'%(PackageDirectory)')</RuntimePackagePath>
       <RuntimePackagePath Condition="'@(ResolvedTargetILCompilerPack)' == ''">@(ResolvedILCompilerPack->'%(PackageDirectory)')</RuntimePackagePath>
+      <RuntimePackagePath Condition="'@(ResolvedTargetILCompilerPack)' != ''">@(ResolvedTargetILCompilerPack->'%(PackageDirectory)')</RuntimePackagePath>
+      <IlcUseNativeAOTRuntimePackLayout Condition="'@(ResolvedTargetILCompilerPack)' == '$(_targetRuntimePackName)'">true</IlcUseNativeAOTRuntimePackLayout>
+      <IlcUseNativeAOTRuntimePackLayout Condition="'$(IlcUseNativeAOTRuntimePackLayout)' == ''">$(PublishAotUsingRuntimePack)</IlcUseNativeAOTRuntimePackLayout>
     </PropertyGroup>
 
   </Target>
diff --git a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Publish.targets b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Publish.targets
index 0e633f34e3b24f..656e525ca32eb7 100644
--- a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Publish.targets
+++ b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Publish.targets
@@ -68,8 +68,8 @@
       Text="Add a PackageReference for '$(_hostPackageName)' to allow cross-compilation for $(_targetArchitecture)" />
 
     <!-- NativeAOT runtime pack assemblies need to be defined to avoid the default CoreCLR implementations being set as compiler inputs -->
-    <Error Condition="'@(PrivateSdkAssemblies)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'" Text="The PrivateSdkAssemblies ItemGroup is required for _ComputeAssembliesToCompileToNative" />
-    <Error Condition="'@(FrameworkAssemblies)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'" Text="The FrameworkAssemblies ItemGroup is required for _ComputeAssembliesToCompileToNative" />
+    <Error Condition="'@(PrivateSdkAssemblies)' == '' and '$(IlcUseNativeAOTRuntimePackLayout)' != 'true'" Text="The PrivateSdkAssemblies ItemGroup is required for _ComputeAssembliesToCompileToNative" />
+    <Error Condition="'@(FrameworkAssemblies)' == '' and '$(IlcUseNativeAOTRuntimePackLayout)' != 'true'" Text="The FrameworkAssemblies ItemGroup is required for _ComputeAssembliesToCompileToNative" />
 
     <ComputeManagedAssembliesToCompileToNative
       Assemblies="@(_ResolvedCopyLocalPublishAssets)"
diff --git a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.targets b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.targets
index 3f156ac50fe48c..2bc334f013d80a 100644
--- a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.targets
+++ b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.targets
@@ -131,25 +131,36 @@ The .NET Foundation licenses this file to you under the MIT license.
       <_NETCoreAppFrameworkReference Include="@(ResolvedFrameworkReference)" Condition="'%(ResolvedFrameworkReference.RuntimePackName)' == 'Microsoft.NETCore.App.Runtime.NativeAOT.$(RuntimeIdentifier)'" />
     </ItemGroup>
 
+    <PropertyGroup Condition="'$(IlcUseNativeAOTRuntimePackLayout)' == 'true'">
+      <!--
+        If we're actually using the runtime pack from the ResolvedFrameworkReference, pull the path from there.
+        Otherwise pull it from the RuntimePackagePath.
+      -->
+      <_NETCoreAppRuntimePackPath Condition="'$(PublishAotUsingRuntimePack)' == 'true'">%(_NETCoreAppFrameworkReference.RuntimePackPath)/runtimes/$(RuntimeIdentifier)/</_NETCoreAppRuntimePackPath>
+      <_NETCoreAppRuntimePackPath Condition="'$(PublishAotUsingRuntimePack)' != 'true'">$(RuntimePackagePath)/runtimes/$(RuntimeIdentifier)/</_NETCoreAppRuntimePackPath>
+      <IlcFrameworkNativePath Condition="'$(IlcFrameworkNativePath)' == ''">$(_NETCoreAppRuntimePackPath)\native\</IlcFrameworkNativePath>
+      <IlcSdkPath Condition="'$(IlcSdkPath)' == ''">$(IlcFrameworkNativePath)</IlcSdkPath>
+    </PropertyGroup>
+
+    <PropertyGroup Condition="'$(IlcUseNativeAOTRuntimePackLayout)' != 'true'">
+      <IlcFrameworkPath Condition="'$(IlcFrameworkPath)' == ''">$(RuntimePackagePath)\framework\</IlcFrameworkPath>
+      <IlcFrameworkNativePath Condition="'$(IlcFrameworkNativePath)' == ''">$(RuntimePackagePath)\framework\</IlcFrameworkNativePath>
+      <IlcSdkPath Condition="'$(IlcSdkPath)' == ''">$(RuntimePackagePath)\sdk\</IlcSdkPath>
+    </PropertyGroup>
+
     <PropertyGroup>
       <!-- Define paths used in build targets to point to the runtime-specific ILCompiler implementation -->
       <IlcToolsPath Condition="'$(IlcToolsPath)' == ''">$(IlcHostPackagePath)\tools\</IlcToolsPath>
-      <IlcFrameworkPath Condition="'$(IlcFrameworkPath)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'">$(RuntimePackagePath)\framework\</IlcFrameworkPath>
-      <_NETCoreAppRuntimePackPath>%(_NETCoreAppFrameworkReference.RuntimePackPath)/runtimes/$(RuntimeIdentifier)/</_NETCoreAppRuntimePackPath>
-      <IlcFrameworkNativePath Condition="'$(IlcFrameworkNativePath)' == '' and '$(PublishAotUsingRuntimePack)' == 'true'">$(_NETCoreAppRuntimePackPath)\native\</IlcFrameworkNativePath>
-      <IlcFrameworkNativePath Condition="'$(IlcFrameworkNativePath)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'">$(RuntimePackagePath)\framework\</IlcFrameworkNativePath>
-      <IlcSdkPath Condition="'$(IlcSdkPath)' == '' and '$(PublishAotUsingRuntimePack)' == 'true'">$(IlcFrameworkNativePath)</IlcSdkPath>
-      <IlcSdkPath Condition="'$(IlcSdkPath)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'">$(RuntimePackagePath)\sdk\</IlcSdkPath>
       <IlcMibcPath Condition="'$(IlcMibcPath)' == ''">$(RuntimePackagePath)\mibc\</IlcMibcPath>
     </PropertyGroup>
 
-    <ItemGroup Condition="'$(PublishAotUsingRuntimePack)' == 'true'">
+    <ItemGroup Condition="'$(IlcUseNativeAOTRuntimePackLayout)' == 'true'">
       <PrivateSdkAssemblies Include="$(IlcSdkPath)*.dll"/>
       <FrameworkAssemblies Include="@(RuntimePackAsset)" Condition="'%(Extension)' == '.dll'" />
       <DefaultFrameworkAssemblies Include="@(FrameworkAssemblies)" />
     </ItemGroup>
 
-    <ItemGroup Condition="'$(PublishAotUsingRuntimePack)' != 'true'">
+    <ItemGroup Condition="'$(IlcUseNativeAOTRuntimePackLayout)' != 'true'">
       <PrivateSdkAssemblies Include="$(IlcSdkPath)*.dll"/>
       <!-- Exclude unmanaged dlls -->
       <FrameworkAssemblies Include="$(IlcFrameworkPath)*.dll" Exclude="$(IlcFrameworkPath)*.Native.dll;$(IlcFrameworkPath)msquic.dll" />
diff --git a/src/installer/pkg/sfx/Microsoft.NETCore.App/Microsoft.NETCore.App.Runtime.NativeAOT.sfxproj b/src/installer/pkg/sfx/Microsoft.NETCore.App/Microsoft.NETCore.App.Runtime.NativeAOT.sfxproj
index 336574ffe10fc7..34587e9fa80607 100644
--- a/src/installer/pkg/sfx/Microsoft.NETCore.App/Microsoft.NETCore.App.Runtime.NativeAOT.sfxproj
+++ b/src/installer/pkg/sfx/Microsoft.NETCore.App/Microsoft.NETCore.App.Runtime.NativeAOT.sfxproj
@@ -20,8 +20,11 @@
 
   <ItemGroup>
     <IgnoredDuplicateType Include="Internal.Runtime.CompilerHelpers.LibraryInitializer" />
+    <FilesToPackage Include="$(CoreCLRArtifactsPath)StandardOptimizationData.mibc"
+                    Condition="Exists('$(CoreCLRArtifactsPath)StandardOptimizationData.mibc')" />
   </ItemGroup>
 
+
   <Import Project="Microsoft.NETCore.App.Runtime.props" />
 
   <Target Name="IncludeSymbolFilesInNativeAOTPackage"