diff --git a/src/coreclr/interpreter/compiler.cpp b/src/coreclr/interpreter/compiler.cpp
index c184a263bf1bf5..9c2dcaf0194dd8 100644
--- a/src/coreclr/interpreter/compiler.cpp
+++ b/src/coreclr/interpreter/compiler.cpp
@@ -1215,8 +1215,13 @@ InterpMethod* InterpCompiler::CreateInterpMethod()
         pDataItems[i] = m_dataItems.Get(i);
 
     bool initLocals = (m_methodInfo->options & CORINFO_OPT_INIT_LOCALS) != 0;
+    CORJIT_FLAGS corJitFlags;
+    DWORD jitFlagsSize = m_compHnd->getJitFlags(&corJitFlags, sizeof(corJitFlags));
+    assert(jitFlagsSize == sizeof(corJitFlags));
 
-    InterpMethod *pMethod = new InterpMethod(m_methodHnd, m_totalVarsStackSize, pDataItems, initLocals);
+    bool unmanagedCallersOnly = corJitFlags.IsSet(CORJIT_FLAGS::CORJIT_FLAG_REVERSE_PINVOKE);
+
+    InterpMethod *pMethod = new InterpMethod(m_methodHnd, m_totalVarsStackSize, pDataItems, initLocals, unmanagedCallersOnly);
 
     return pMethod;
 }
@@ -3038,9 +3043,13 @@ void InterpCompiler::EmitCall(CORINFO_RESOLVED_TOKEN* pConstrainedToken, bool re
                     CORINFO_CONST_LOOKUP lookup;
                     m_compHnd->getAddressOfPInvokeTarget(callInfo.hMethod, &lookup);
                     m_pLastNewIns->data[1] = GetDataItemIndex(lookup.addr);
-                    m_pLastNewIns->data[2] = lookup.accessType == IAT_PVALUE;
                     if (lookup.accessType == IAT_PPVALUE)
                         NO_WAY("IAT_PPVALUE pinvokes not implemented in interpreter");
+                    bool suppressGCTransition = false;
+                    m_compHnd->getUnmanagedCallConv(callInfo.hMethod, nullptr, &suppressGCTransition);
+                    m_pLastNewIns->data[2] =
+                        ((lookup.accessType == IAT_PVALUE) ? (int32_t)PInvokeCallFlags::Indirect : 0) |
+                        (suppressGCTransition ? (int32_t)PInvokeCallFlags::SuppressGCTransition : 0);
                 }
             }
             break;
diff --git a/src/coreclr/interpreter/interpretershared.h b/src/coreclr/interpreter/interpretershared.h
index b4bb490237ed6d..d9338543d8ea24 100644
--- a/src/coreclr/interpreter/interpretershared.h
+++ b/src/coreclr/interpreter/interpretershared.h
@@ -35,8 +35,9 @@ struct InterpMethod
     // This stub is used for calling the interpreted method from JITted/AOTed code
     CallStubHeader *pCallStub;
     bool initLocals;
+    bool unmanagedCallersOnly;
 
-    InterpMethod(CORINFO_METHOD_HANDLE methodHnd, int32_t allocaSize, void** pDataItems, bool initLocals)
+    InterpMethod(CORINFO_METHOD_HANDLE methodHnd, int32_t allocaSize, void** pDataItems, bool initLocals, bool unmanagedCallersOnly)
     {
 #if DEBUG
         this->self = this;
@@ -45,6 +46,7 @@ struct InterpMethod
         this->allocaSize = allocaSize;
         this->pDataItems = pDataItems;
         this->initLocals = initLocals;
+        this->unmanagedCallersOnly = unmanagedCallersOnly;
         pCallStub = NULL;
     }
 
@@ -157,4 +159,11 @@ struct InterpGenericLookup
     uint16_t                offsets[InterpGenericLookup_MaxIndirections];
 };
 
+enum class PInvokeCallFlags : int32_t
+{
+    None = 0,
+    Indirect = 1 << 0, // The call target address is indirect
+    SuppressGCTransition = 1 << 1, // The pinvoke is marked by the SuppressGCTransition attribute
+};
+
 #endif
diff --git a/src/coreclr/vm/interpexec.cpp b/src/coreclr/vm/interpexec.cpp
index 3419a19710d3b3..d81c2a2d0a0b60 100644
--- a/src/coreclr/vm/interpexec.cpp
+++ b/src/coreclr/vm/interpexec.cpp
@@ -1855,11 +1855,11 @@ void InterpExecMethod(InterpreterFrame *pInterpreterFrame, InterpMethodContextFr
                     callArgsOffset = ip[2];
                     methodSlot = ip[3];
                     int32_t targetAddrSlot = ip[4];
-                    int32_t indirectFlag = ip[5];
+                    int32_t flags = ip[5];
 
                     ip += 6;
                     targetMethod = (MethodDesc*)pMethod->pDataItems[methodSlot];
-                    PCODE callTarget = indirectFlag
+                    PCODE callTarget = (flags & (int32_t)PInvokeCallFlags::Indirect)
                         ? *(PCODE *)pMethod->pDataItems[targetAddrSlot]
                         : (PCODE)pMethod->pDataItems[targetAddrSlot];
 
@@ -1872,7 +1872,7 @@ void InterpExecMethod(InterpreterFrame *pInterpreterFrame, InterpMethodContextFr
                     inlinedCallFrame.Push();
 
                     {
-                        GCX_PREEMP();
+                        GCX_MAYBE_PREEMP(!(flags & (int32_t)PInvokeCallFlags::SuppressGCTransition));
                         InvokeCompiledMethod(targetMethod, stack + callArgsOffset, stack + returnOffset, callTarget);
                     }
 
diff --git a/src/coreclr/vm/prestub.cpp b/src/coreclr/vm/prestub.cpp
index f9da780c74c417..3ea82cfe8ae4d2 100644
--- a/src/coreclr/vm/prestub.cpp
+++ b/src/coreclr/vm/prestub.cpp
@@ -2001,6 +2001,8 @@ static InterpThreadContext* GetInterpThreadContext()
     return threadContext;
 }
 
+EXTERN_C void STDCALL ReversePInvokeBadTransition();
+
 extern "C" void* STDCALL ExecuteInterpretedMethod(TransitionBlock* pTransitionBlock, TADDR byteCodeAddr, void* retBuff)
 {
     // Argument registers are in the TransitionBlock
@@ -2008,6 +2010,21 @@ extern "C" void* STDCALL ExecuteInterpretedMethod(TransitionBlock* pTransitionBl
     InterpThreadContext *threadContext = GetInterpThreadContext();
     int8_t *sp = threadContext->pStackPointer;
 
+    InterpByteCodeStart* pInterpreterCode = dac_cast<PTR_InterpByteCodeStart>(byteCodeAddr);
+
+    if (pInterpreterCode->Method->unmanagedCallersOnly)
+    {
+        Thread* thread = GetThreadNULLOk();
+        if (thread == NULL)
+            CREATETHREAD_IF_NULL_FAILFAST(thread, W("Failed to setup new thread during reverse P/Invoke"));
+
+        // Verify the current thread isn't in COOP mode.
+        if (thread->PreemptiveGCDisabled())
+            ReversePInvokeBadTransition();
+    }
+
+    GCX_MAYBE_COOP(pInterpreterCode->Method->unmanagedCallersOnly);
+
     // This construct ensures that the InterpreterFrame is always stored at a higher address than the
     // InterpMethodContextFrame. This is important for the stack walking code.
     struct Frames