diff --git a/src/libraries/System.Text.Json/src/System/Text/Json/Reader/JsonReaderHelper.net8.cs b/src/libraries/System.Text.Json/src/System/Text/Json/Reader/JsonReaderHelper.net8.cs
index 08f72de280193c..8bfa2da0c0986e 100644
--- a/src/libraries/System.Text.Json/src/System/Text/Json/Reader/JsonReaderHelper.net8.cs
+++ b/src/libraries/System.Text.Json/src/System/Text/Json/Reader/JsonReaderHelper.net8.cs
@@ -2,7 +2,11 @@
 // The .NET Foundation licenses this file to you under the MIT license.
 
 using System.Buffers;
+using System.Numerics;
 using System.Runtime.CompilerServices;
+using System.Runtime.InteropServices;
+using System.Runtime.Intrinsics;
+using System.Runtime.Intrinsics.Arm;
 
 namespace System.Text.Json
 {
@@ -12,14 +16,38 @@ internal static partial class JsonReaderHelper
         /// <remarks>https://tools.ietf.org/html/rfc8259</remarks>
         private static readonly SearchValues<byte> s_controlQuoteBackslash = SearchValues.Create(
             // Any Control, < 32 (' ')
-            "\u0000\u0001\u0002\u0003\u0004\u0005\u0006\u0007\u0008\u0009\u000A\u000B\u000C\u000D\u000E\u000F\u0010\u0011\u0012\u0013\u0014\u0015\u0016\u0017\u0018\u0019\u001A\u001B\u001C\u001D\u001E\u001F"u8 +
-            // Quote
-            "\""u8 +
-            // Backslash
-            "\\"u8);
+            "\u0000\u0001\u0002\u0003\u0004\u0005\u0006\u0007\u0008\u0009"u8 +
+            "\u000A\u000B\u000C\u000D\u000E\u000F\u0010\u0011\u0012\u0013"u8 +
+            "\u0014\u0015\u0016\u0017\u0018\u0019\u001A\u001B\u001C\u001D"u8 +
+            "\u001E\u001F\"\\"u8);
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
-        public static int IndexOfQuoteOrAnyControlOrBackSlash(this ReadOnlySpan<byte> span) =>
-            span.IndexOfAny(s_controlQuoteBackslash);
+        public static int IndexOfQuoteOrAnyControlOrBackSlash(this ReadOnlySpan<byte> span)
+        {
+            // Fast path for " in the first 16 bytes
+            if (Vector128.IsHardwareAccelerated && span.Length >= 16)
+            {
+                ref byte ptr = ref MemoryMarshal.GetReference(span);
+                Vector128<byte> matches = Vector128.Equals(Vector128.LoadUnsafe(ref ptr), Vector128.Create((byte)'"'));
+                if (AdvSimd.IsSupported)
+                {
+                    // TODO: use Vector128.IndexOf for both AdvSimd and Sse2 once
+                    ulong mask = AdvSimd.ShiftRightLogicalNarrowingLower(matches.AsUInt16(), 4).AsUInt64().ToScalar();
+                    if (mask != 0)
+                    {
+                        return BitOperations.TrailingZeroCount(mask) >> 2;
+                    }
+                }
+                else
+                {
+                    uint mask = matches.ExtractMostSignificantBits();
+                    if (mask != 0)
+                    {
+                        return BitOperations.TrailingZeroCount(mask);
+                    }
+                }
+            }
+            return span.IndexOfAny(s_controlQuoteBackslash);
+        }
     }
 }