diff --git a/src/native/managed/cdac/tests/DumpTests/DumpTestBase.cs b/src/native/managed/cdac/tests/DumpTests/DumpTestBase.cs
index 0da34a20d74821..f1c826f951743f 100644
--- a/src/native/managed/cdac/tests/DumpTests/DumpTestBase.cs
+++ b/src/native/managed/cdac/tests/DumpTests/DumpTestBase.cs
@@ -142,6 +142,18 @@ private void EvaluateSkipAttributes(TestConfiguration config, string callerName,
 
         if (_dumpInfo is not null)
         {
+            // Cross-bitness dump reading is not yet supported when a 32-bit host
+            // tries to read a 64-bit dump (see microsoft/clrmd#1423).
+            // The reverse (64-bit host reading 32-bit dump) works fine.
+            bool isDump64Bit = _dumpInfo.Arch is "x64" or "arm64" or "riscv64" or "loongarch64";
+            bool isHost64Bit = IntPtr.Size == 8;
+            if (isDump64Bit && !isHost64Bit)
+            {
+                throw new SkipTestException(
+                    $"32-bit host cannot read 64-bit dumps: dump is {_dumpInfo.Arch}. " +
+                    $"See microsoft/clrmd#1423.");
+            }
+
             foreach (SkipOnOSAttribute attr in method.GetCustomAttributes<SkipOnOSAttribute>())
             {
                 if (attr.IncludeOnly is not null)