diff --git a/src/libraries/System.Diagnostics.StackTrace/tests/StackTraceTests.cs b/src/libraries/System.Diagnostics.StackTrace/tests/StackTraceTests.cs
index 0145acfb9aecd8..aa57a823d25cf0 100644
--- a/src/libraries/System.Diagnostics.StackTrace/tests/StackTraceTests.cs
+++ b/src/libraries/System.Diagnostics.StackTrace/tests/StackTraceTests.cs
@@ -652,6 +652,7 @@ public static IEnumerable<object[]> Ctor_Async_TestData()
         }
 
         [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.IsRuntimeAsyncSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/50957", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         [MemberData(nameof(Ctor_Async_TestData))]
         [MethodImpl(MethodImplOptions.NoOptimization | MethodImplOptions.NoInlining)]
         public async Task ToString_Async(Func<Task> asyncMethod, string[] expectedPatterns)
diff --git a/src/libraries/System.Runtime.Loader/tests/CollectibleAssemblyLoadContextTest.cs b/src/libraries/System.Runtime.Loader/tests/CollectibleAssemblyLoadContextTest.cs
index 9a717078bc1741..319ad51f0eeb00 100644
--- a/src/libraries/System.Runtime.Loader/tests/CollectibleAssemblyLoadContextTest.cs
+++ b/src/libraries/System.Runtime.Loader/tests/CollectibleAssemblyLoadContextTest.cs
@@ -33,6 +33,7 @@ static void CreateAndLoadContext(CollectibleChecker checker, bool unloadTwice =
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_CollectibleWithNoAssemblyLoaded()
         {
             // Use a collectible ALC + Unload
@@ -45,6 +46,7 @@ public static void Unload_CollectibleWithNoAssemblyLoaded()
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void DoubleUnload_CollectibleWithNoAssemblyLoaded()
         {
             // Use a collectible ALC + Unload
@@ -127,6 +129,7 @@ class CollectibleWithOneAssemblyLoadedTest : TestBase
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_CollectibleWithOneAssemblyLoaded()
         {
             // Use a collectible ALC + Load an assembly by path + Unload
@@ -154,6 +157,7 @@ public void Execute()
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_CollectibleWithOneAssemblyLoadedWithStatic()
         {
             // Use a collectible ALC + Load an assembly by path + New Instance + Static reference + Unload
@@ -186,6 +190,7 @@ public void CheckInstanceUnloaded()
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_CollectibleWithOneAssemblyLoadedWithWeakReferenceToType()
         {
             // Use a collectible ALC + Load an assembly by path + WeakReference on the Type + Unload
@@ -220,6 +225,7 @@ public void CheckInstanceUnloaded()
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_CollectibleWithOneAssemblyLoadedWithWeakReferenceToInstance()
         {
             // Use a collectible ALC + Load an assembly by path + WeakReference on an instance of a Type + Unload
@@ -272,6 +278,7 @@ public void CheckTypeUnloaded()
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_CollectibleWithOneAssemblyLoadedWithStrongReferenceToType()
         {
             // Use a collectible ALC + Load an assembly by path + Strong reference on the Type + Unload
@@ -333,6 +340,7 @@ public void CheckInstanceUnloaded()
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_CollectibleWithOneAssemblyLoadedWithStrongReferenceToInstance()
         {
             // Use a collectible ALC + Load an assembly by path + Strong reference on an instance of a Type + Unload
@@ -367,6 +375,7 @@ public void Execute()
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_CollectibleWithTwoAssemblies()
         {
             // Use a collectible ALC + Load two assemblies (path + stream) + Unload
@@ -428,6 +437,7 @@ public void CheckContextUnloaded2()
 
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_TwoCollectibleWithOneAssemblyAndOneInstanceReferencingAnother()
         {
             // We create 2 collectible ALC, load one assembly in each, create one instance in each, reference one instance from ALC1 to ALC2
@@ -497,6 +507,7 @@ public void CheckContextUnloaded2()
         // Test may fail when running on a different runtime
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34072", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser))]
         public static void Unload_TwoCollectibleWithOneAssemblyAndOneInstanceReferencingAnotherThroughGenericStatic()
         {
             // We create 2 collectible ALC, load one assembly in each, create one instance in the ALC2,
diff --git a/src/libraries/System.Runtime/tests/System.IO.FileSystem.Tests/FileStream/Dispose.cs b/src/libraries/System.Runtime/tests/System.IO.FileSystem.Tests/FileStream/Dispose.cs
index 803ebbb5edd6e5..e4fe6560cbacd3 100644
--- a/src/libraries/System.Runtime/tests/System.IO.FileSystem.Tests/FileStream/Dispose.cs
+++ b/src/libraries/System.Runtime/tests/System.IO.FileSystem.Tests/FileStream/Dispose.cs
@@ -169,7 +169,7 @@ public void Dispose_CallsVirtualDispose_TrueArg()
             Assert.False(disposeInvoked, "Expected finalizer to have been suppressed");
         }
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported), nameof(PlatformDetection.IsNotBrowser))]
         public void Finalizer_CallsVirtualDispose_FalseArg()
         {
             bool disposeInvoked = false;
@@ -345,24 +345,24 @@ public void VerifyAfterDispose()
             }
         }
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported), nameof(PlatformDetection.IsNotBrowser))]
         public void FinalizeFlushesWriteBuffer()
             => VerifyFlushedBufferOnFinalization(
                 filePath => new FileStream(filePath, FileMode.Create, FileAccess.Write, FileShare.ReadWrite | FileShare.Delete, bufferSize: 4096, useAsync: false));
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported), nameof(PlatformDetection.IsNotBrowser))]
         public void FinalizeFlushesWriteBufferForDerivedFileStreamWithFinalizerCreatedFromPath()
             => VerifyFlushedBufferOnFinalization(
                 filePath => new DerivedFileStreamWithFinalizer(filePath, FileMode.Create, FileAccess.Write, FileShare.ReadWrite | FileShare.Delete, bufferSize: 4096, FileOptions.None));
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported), nameof(PlatformDetection.IsNotBrowser))]
         public void FinalizeFlushesWriteBufferForDerivedFileStreamWithFinalizerCreatedFromSafeFileHandle()
             => VerifyFlushedBufferOnFinalization(
                 filePath => new DerivedFileStreamWithFinalizer(
                     File.OpenHandle(filePath, FileMode.Create, FileAccess.Write, FileShare.ReadWrite | FileShare.Delete, FileOptions.None),
                     FileAccess.Write, bufferSize: 4096, isAsync: false));
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported), nameof(PlatformDetection.IsNotBrowser))]
         public void FinalizeFlushesWriteBufferForDerivedFileStreamWithFinalizerCreatedFromIntPtr()
              => VerifyFlushedBufferOnFinalization(
                 filePath => new DerivedFileStreamWithFinalizer(
@@ -370,19 +370,19 @@ public void FinalizeFlushesWriteBufferForDerivedFileStreamWithFinalizerCreatedFr
                     FileAccess.Write,
                     ownsHandle: true));
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported), nameof(PlatformDetection.IsNotBrowser))]
         public void FinalizeFlushesWriteBufferForDerivedFileStreamWithoutFinalizerCreatedFromPath()
             => VerifyFlushedBufferOnFinalization(
                 filePath => new DerivedFileStreamWithoutFinalizer(filePath, FileMode.Create, FileAccess.Write, FileShare.ReadWrite | FileShare.Delete, bufferSize: 4096, FileOptions.None));
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported), nameof(PlatformDetection.IsNotBrowser))]
         public void FinalizeFlushesWriteBufferForDerivedFileStreamWithoutFinalizerCreatedFromSafeFileHandle()
             => VerifyFlushedBufferOnFinalization(
                 filePath => new DerivedFileStreamWithoutFinalizer(
                     File.OpenHandle(filePath, FileMode.Create, FileAccess.Write, FileShare.ReadWrite | FileShare.Delete, FileOptions.None),
                     FileAccess.Write, bufferSize: 4096, isAsync: false));
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsPreciseGcSupported), nameof(PlatformDetection.IsNotBrowser))]
         public void FinalizeFlushesWriteBufferForDerivedFileStreamWithoutFinalizerCreatedFromIntPtr()
              => VerifyFlushedBufferOnFinalization(
                 filePath => new DerivedFileStreamWithoutFinalizer(
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index e652997a3d5ef1..c935f3a2b57692 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -183,15 +183,8 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime\tests\System.IO.FileSystem.Tests\DisabledFileLockingTests\System.IO.FileSystem.DisabledFileLocking.Tests.csproj" />
   </ItemGroup>
 
-  <!-- https://github.com/dotnet/runtime/issues/125495 - These tests are disabled on browser/CoreCLR because of build errors and test failures. -->
+  <!-- https://github.com/dotnet/runtime/issues/125495 - These tests are disabled on browser/CoreCLR because of crashes and test failures. -->
   <ItemGroup Condition="'$(TargetOS)' == 'browser' and '$(RuntimeFlavor)' == 'CoreCLR' and '$(RunDisabledWasmTests)' != 'true'">
-    <!-- build errors, WasmTriggerPublishApp for CoreCLR not implemented -->
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime\tests\System.IO.FileSystem.Tests\System.IO.FileSystem.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Reflection.MetadataLoadContext\tests\System.Reflection.MetadataLoadContext.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Reflection.Metadata\tests\System.Reflection.Metadata.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Loader\tests\System.Runtime.Loader.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Diagnostics.StackTrace\tests\System.Diagnostics.StackTrace.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime\tests\System.Reflection.Tests\System.Reflection.Tests.csproj" />
     <!-- crashes -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.DependencyInjection\tests\DI.Tests\Microsoft.Extensions.DependencyInjection.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.VisualBasic.Core\tests\Microsoft.VisualBasic.Core.Tests.csproj" />