diff --git a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/HandleCallAction.cs b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/HandleCallAction.cs
index e286aa17bbebd1..016c0e7f270458 100644
--- a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/HandleCallAction.cs
+++ b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/HandleCallAction.cs
@@ -87,7 +87,7 @@ private partial bool TryHandleIntrinsic(
                                             }
                                             else
                                             {
-                                                _reflectionMarker.RuntimeDeterminedDependencies.Add(new MakeGenericTypeSite(typeInstantiated));
+                                                _reflectionMarker.RuntimeDeterminedDependencies.Add((_callingMethod, new MakeGenericTypeSite(typeInstantiated)));
                                             }
                                         }
                                     }
@@ -160,7 +160,7 @@ private partial bool TryHandleIntrinsic(
                                             }
                                             else
                                             {
-                                                _reflectionMarker.RuntimeDeterminedDependencies.Add(new MakeGenericMethodSite(methodInstantiated));
+                                                _reflectionMarker.RuntimeDeterminedDependencies.Add((_callingMethod, new MakeGenericMethodSite(methodInstantiated)));
                                             }
                                         }
                                     }
diff --git a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/ReflectionMarker.cs b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/ReflectionMarker.cs
index cb05aa36cb6099..eefe7999dcb9a4 100644
--- a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/ReflectionMarker.cs
+++ b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/ReflectionMarker.cs
@@ -30,7 +30,7 @@ public class ReflectionMarker
         public NodeFactory Factory { get; }
         public FlowAnnotations Annotations { get; }
         public DependencyList Dependencies { get => _dependencies; }
-        public List<INodeWithRuntimeDeterminedDependencies> RuntimeDeterminedDependencies { get; } = new List<INodeWithRuntimeDeterminedDependencies>();
+        public List<(MethodDesc OwningMethod, INodeWithRuntimeDeterminedDependencies Dependency)> RuntimeDeterminedDependencies { get; } = new List<(MethodDesc, INodeWithRuntimeDeterminedDependencies)>();
 
         internal enum AccessKind
         {
diff --git a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/ReflectionMethodBodyScanner.cs b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/ReflectionMethodBodyScanner.cs
index b2eb6834f97b5b..c9a3cd14f19770 100644
--- a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/ReflectionMethodBodyScanner.cs
+++ b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/Dataflow/ReflectionMethodBodyScanner.cs
@@ -124,7 +124,7 @@ protected override void Scan(MethodIL methodIL, ref InterproceduralState interpr
             base.Scan(methodIL, ref interproceduralState);
         }
 
-        public static DependencyList ScanAndProcessReturnValue(NodeFactory factory, FlowAnnotations annotations, Logger logger, MethodIL methodIL, out List<INodeWithRuntimeDeterminedDependencies> runtimeDependencies)
+        public static DependencyList ScanAndProcessReturnValue(NodeFactory factory, FlowAnnotations annotations, Logger logger, MethodIL methodIL, out List<(MethodDesc OwningMethod, INodeWithRuntimeDeterminedDependencies Dependency)> runtimeDependencies)
         {
 #if !ILTRIM
             methodIL = AsyncMaskingILProvider.WrapIL(methodIL);
diff --git a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/DependencyAnalysis/DataflowAnalyzedMethodNode.cs b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/DependencyAnalysis/DataflowAnalyzedMethodNode.cs
index 026b9a54028948..07533b6b600921 100644
--- a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/DependencyAnalysis/DataflowAnalyzedMethodNode.cs
+++ b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/DependencyAnalysis/DataflowAnalyzedMethodNode.cs
@@ -19,7 +19,7 @@ namespace ILCompiler.DependencyAnalysis
     public class DataflowAnalyzedMethodNode : DependencyNodeCore<NodeFactory>
     {
         private readonly MethodIL _methodIL;
-        private List<INodeWithRuntimeDeterminedDependencies> _runtimeDependencies;
+        private List<(MethodDesc OwningMethod, INodeWithRuntimeDeterminedDependencies Dependency)> _runtimeDependencies;
 
         public DataflowAnalyzedMethodNode(MethodIL methodIL)
         {
@@ -39,29 +39,30 @@ public override IEnumerable<DependencyListEntry> GetStaticDependencies(NodeFacto
             {
                 // Something wrong with the input - missing references, etc.
                 // The method body likely won't compile either, so we don't care.
-                _runtimeDependencies = new List<INodeWithRuntimeDeterminedDependencies>();
+                _runtimeDependencies = new List<(MethodDesc, INodeWithRuntimeDeterminedDependencies)>();
                 return Array.Empty<DependencyListEntry>();
             }
         }
 
         public override IEnumerable<CombinedDependencyListEntry> SearchDynamicDependencies(List<DependencyNodeCore<NodeFactory>> markedNodes, int firstNode, NodeFactory factory)
         {
-            MethodDesc analyzedMethod = _methodIL.OwningMethod;
-
-            // Look for any generic specialization of this method. If any are found, specialize any dataflow dependencies.
+            // Look for any generic specialization of this method or its compiler-generated callees (local methods, lambdas).
+            // If any are found, specialize the dataflow dependencies that originated from that method.
             for (int i = firstNode; i < markedNodes.Count; i++)
             {
                 if (markedNodes[i] is not IMethodBodyNode methodBody)
                     continue;
 
                 MethodDesc method = methodBody.Method;
-                if (method.GetTypicalMethodDefinition() != analyzedMethod)
-                    continue;
+                MethodDesc typicalMethod = method.GetTypicalMethodDefinition();
 
-                // Instantiate all runtime dependencies for the found generic specialization
+                // Instantiate runtime dependencies whose owning method matches this method body's typical definition
                 foreach (var n in _runtimeDependencies)
                 {
-                    foreach (var d in n.InstantiateDependencies(factory, method.OwningType.Instantiation, method.Instantiation, isConcreteInstantiation: !method.IsSharedByGenericInstantiations))
+                    if (n.OwningMethod != typicalMethod)
+                        continue;
+
+                    foreach (var d in n.Dependency.InstantiateDependencies(factory, method.OwningType.Instantiation, method.Instantiation, isConcreteInstantiation: !method.IsSharedByGenericInstantiations))
                     {
                         yield return new CombinedDependencyListEntry(d.Node, null, d.Reason);
                     }
diff --git a/src/tests/nativeaot/SmokeTests/TrimmingBehaviors/Dataflow.cs b/src/tests/nativeaot/SmokeTests/TrimmingBehaviors/Dataflow.cs
index c275b2a8b2c9d0..b4b4239c8bc240 100644
--- a/src/tests/nativeaot/SmokeTests/TrimmingBehaviors/Dataflow.cs
+++ b/src/tests/nativeaot/SmokeTests/TrimmingBehaviors/Dataflow.cs
@@ -31,6 +31,7 @@ public static int Run()
         TestMakeGenericConstrainedDataflow.Run();
         TestMarshalIntrinsics.Run();
         Regression97758.Run();
+        TestMakeGenericDataflowInLocalMethod.Run();
 
         return 100;
     }
@@ -792,6 +793,28 @@ public static void Run()
             Foo<int>.Trigger();
         }
     }
+
+    class TestMakeGenericDataflowInLocalMethod
+    {
+        class Gen<T> { }
+
+        struct Atom { }
+
+        class GenMethods
+        {
+            public static void Bridge<T>() { }
+        }
+
+        public static void Run()
+        {
+            MakeGenericType<Atom>();
+            MakeGenericMethod<Atom>();
+
+            static object MakeGenericType<T>() => Activator.CreateInstance(typeof(Gen<>).MakeGenericType(typeof(T)));
+
+            static void MakeGenericMethod<T>() => typeof(GenMethods).GetMethod(nameof(GenMethods.Bridge)).MakeGenericMethod(typeof(T)).Invoke(null, []);
+        }
+    }
 }
 
 static class Assert