diff --git a/src/coreclr/src/vm/gcenv.os.cpp b/src/coreclr/src/vm/gcenv.os.cpp
index c0ed7d79733539..6b9e042f04e9b2 100644
--- a/src/coreclr/src/vm/gcenv.os.cpp
+++ b/src/coreclr/src/vm/gcenv.os.cpp
@@ -47,8 +47,8 @@ class GroupProcNo
     GroupProcNo(uint16_t group, uint16_t procIndex) : m_groupProc((group << 6) | procIndex)
     {
         // Making this the same as the # of NUMA node we support.
-        assert(group < 0x40);
-        assert(procIndex <= 0x3f);
+        _ASSERTE(group < 0x40);
+        _ASSERTE(procIndex <= 0x3f);
     }
 
     uint16_t GetGroup() { return m_groupProc >> 6; }
@@ -120,7 +120,7 @@ bool GCToOSInterface::Initialize()
     uint32_t currentProcessCpuCount = PAL_GetLogicalCpuCountFromOS();
     if (PAL_GetCurrentThreadAffinitySet(AffinitySet::BitsetDataSize, g_processAffinitySet.GetBitsetData()))
     {
-        assert(currentProcessCpuCount == g_processAffinitySet.Count());
+        _ASSERTE(currentProcessCpuCount == g_processAffinitySet.Count());
     }
     else
     {
@@ -1322,7 +1322,7 @@ class GCEvent::Impl
     {
         WRAPPER_NO_CONTRACT;
 
-        assert(m_event.IsValid());
+        _ASSERTE(m_event.IsValid());
         m_event.CloseEvent();
     }
 
@@ -1330,7 +1330,7 @@ class GCEvent::Impl
     {
         WRAPPER_NO_CONTRACT;
 
-        assert(m_event.IsValid());
+        _ASSERTE(m_event.IsValid());
         m_event.Set();
     }
 
@@ -1338,7 +1338,7 @@ class GCEvent::Impl
     {
         WRAPPER_NO_CONTRACT;
 
-        assert(m_event.IsValid());
+        _ASSERTE(m_event.IsValid());
         m_event.Reset();
     }
 
@@ -1346,7 +1346,7 @@ class GCEvent::Impl
     {
         WRAPPER_NO_CONTRACT;
 
-        assert(m_event.IsValid());
+        _ASSERTE(m_event.IsValid());
         return m_event.Wait(timeout, alertable);
     }
 
@@ -1400,7 +1400,7 @@ void GCEvent::CloseEvent()
 {
     WRAPPER_NO_CONTRACT;
 
-    assert(m_impl != nullptr);
+    _ASSERTE(m_impl != nullptr);
     m_impl->CloseEvent();
 }
 
@@ -1408,7 +1408,7 @@ void GCEvent::Set()
 {
     WRAPPER_NO_CONTRACT;
 
-    assert(m_impl != nullptr);
+    _ASSERTE(m_impl != nullptr);
     m_impl->Set();
 }
 
@@ -1416,7 +1416,7 @@ void GCEvent::Reset()
 {
     WRAPPER_NO_CONTRACT;
 
-    assert(m_impl != nullptr);
+    _ASSERTE(m_impl != nullptr);
     m_impl->Reset();
 }
 
@@ -1424,7 +1424,7 @@ uint32_t GCEvent::Wait(uint32_t timeout, bool alertable)
 {
     WRAPPER_NO_CONTRACT;
 
-    assert(m_impl != nullptr);
+    _ASSERTE(m_impl != nullptr);
     return m_impl->Wait(timeout, alertable);
 }
 
@@ -1435,7 +1435,7 @@ bool GCEvent::CreateManualEventNoThrow(bool initialState)
       GC_NOTRIGGER;
     } CONTRACTL_END;
 
-    assert(m_impl == nullptr);
+    _ASSERTE(m_impl == nullptr);
     NewHolder<GCEvent::Impl> event = new (nothrow) GCEvent::Impl();
     if (!event)
     {
@@ -1454,7 +1454,7 @@ bool GCEvent::CreateAutoEventNoThrow(bool initialState)
       GC_NOTRIGGER;
     } CONTRACTL_END;
 
-    assert(m_impl == nullptr);
+    _ASSERTE(m_impl == nullptr);
     NewHolder<GCEvent::Impl> event = new (nothrow) GCEvent::Impl();
     if (!event)
     {
@@ -1473,7 +1473,7 @@ bool GCEvent::CreateOSAutoEventNoThrow(bool initialState)
       GC_NOTRIGGER;
     } CONTRACTL_END;
 
-    assert(m_impl == nullptr);
+    _ASSERTE(m_impl == nullptr);
     NewHolder<GCEvent::Impl> event = new (nothrow) GCEvent::Impl();
     if (!event)
     {
@@ -1492,7 +1492,7 @@ bool GCEvent::CreateOSManualEventNoThrow(bool initialState)
       GC_NOTRIGGER;
     } CONTRACTL_END;
 
-    assert(m_impl == nullptr);
+    _ASSERTE(m_impl == nullptr);
     NewHolder<GCEvent::Impl> event = new (nothrow) GCEvent::Impl();
     if (!event)
     {
diff --git a/src/coreclr/src/vm/siginfo.cpp b/src/coreclr/src/vm/siginfo.cpp
index 58b8d86f5b5c86..dc21a23eac1eb5 100644
--- a/src/coreclr/src/vm/siginfo.cpp
+++ b/src/coreclr/src/vm/siginfo.cpp
@@ -1356,7 +1356,7 @@ TypeHandle SigPointer::GetTypeHandleThrowing(
                             if (tmpEType == ELEMENT_TYPE_CLASS)
                                 typeHnd = TypeHandle(g_pCanonMethodTableClass);
                         }
-                        else if ((elemType == (CorElementType) ELEMENT_TYPE_CANON_ZAPSIG) ||
+                        else if ((elemType == (CorElementType)ELEMENT_TYPE_CANON_ZAPSIG) ||
                                  (CorTypeInfo::GetGCType_NoThrow(elemType) == TYPE_GC_REF))
                         {
                             typeHnd = TypeHandle(g_pCanonMethodTableClass);
@@ -1389,6 +1389,11 @@ TypeHandle SigPointer::GetTypeHandleThrowing(
                         thisinst = NULL;
                         break;
                     }
+
+                    if (dropGenericArgumentLevel && level == CLASS_LOAD_APPROXPARENTS)
+                    {
+                        typeHnd = ClassLoader::CanonicalizeGenericArg(typeHnd);
+                    }
                 }
                 thisinst[i] = typeHnd;
                 IfFailThrowBF(psig.SkipExactlyOne(), BFA_BAD_SIGNATURE, pOrigModule);
diff --git a/src/coreclr/tests/src/GC/Regressions/Github/runtime_32848/runtime_32848.cs b/src/coreclr/tests/src/GC/Regressions/Github/runtime_32848/runtime_32848.cs
new file mode 100644
index 00000000000000..34d0dec01bf0c4
--- /dev/null
+++ b/src/coreclr/tests/src/GC/Regressions/Github/runtime_32848/runtime_32848.cs
@@ -0,0 +1,75 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+// See the LICENSE file in the project root for more information.
+
+using System;
+using System.Diagnostics;
+using System.Runtime.CompilerServices;
+
+public struct MyStruct<TRequest, TResponse>
+{
+    int _id;
+    public MyStruct(int id) { _id = id; }
+    public override string ToString() => this.GetType().ToString() + " = " + _id;
+}
+
+public struct GenStruct<T> { }
+
+public sealed class MyStructWrapper<TRequest, TResponse>
+{
+    public MyStruct<TRequest, TResponse> _field;
+
+    public MyStructWrapper(MyStruct<TRequest, TResponse> value)
+    {
+        _field = value;
+    }
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    public override string ToString() => _field.ToString();
+}
+
+public abstract class BaseStructCreator
+{
+    public abstract MyStructWrapper<TRequest, TResponse> GetMyStructWrapper<TRequest, TResponse>() where TRequest : class;
+}
+
+public class StructCreator : BaseStructCreator
+{
+    public override MyStructWrapper<TRequest, TResponse> GetMyStructWrapper<TRequest, TResponse>()
+    {
+        return new MyStructWrapper<TRequest, TResponse>(CreateCall<TRequest, TResponse>());
+    }
+    protected virtual MyStruct<TRequest, TResponse> CreateCall<TRequest, TResponse>() where TRequest : class
+    {
+        return new MyStruct<TRequest, TResponse>(123);
+    }
+}
+
+class DerivedCreator : StructCreator
+{
+    protected override MyStruct<TRequest, TResponse> CreateCall<TRequest, TResponse>()
+    {
+        return new MyStruct<TRequest, TResponse>(456);
+    }
+}
+
+public class Test
+{
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static string RunTest()
+    {
+        var creator = new DerivedCreator();
+        var wrapper = creator.GetMyStructWrapper<Exception, GenStruct<string>>();
+        return wrapper.ToString();
+    }
+    public static int Main()
+    {
+        Console.WriteLine("Expected: MyStruct`2[System.Exception,GenStruct`1[System.String]] = 456");
+
+        string result = RunTest();
+        Console.WriteLine("Actual  : " + result);
+        
+        string expected = "MyStruct`2[System.Exception,GenStruct`1[System.String]] = 456";
+        return result == expected ? 100 : -1;
+    }
+}
diff --git a/src/coreclr/tests/src/GC/Regressions/Github/runtime_32848/runtime_32848.csproj b/src/coreclr/tests/src/GC/Regressions/Github/runtime_32848/runtime_32848.csproj
new file mode 100644
index 00000000000000..9732b0b497875e
--- /dev/null
+++ b/src/coreclr/tests/src/GC/Regressions/Github/runtime_32848/runtime_32848.csproj
@@ -0,0 +1,9 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <OutputType>Exe</OutputType>
+    <CLRTestKind>BuildAndRun</CLRTestKind>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="$(MSBuildProjectName).cs" />
+  </ItemGroup>
+</Project>