diff --git a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/GetDelegateForFunctionPointerTests.cs b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/GetDelegateForFunctionPointerTests.cs
index c04d683d45b575..6f12389d33fc4b 100644
--- a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/GetDelegateForFunctionPointerTests.cs
+++ b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/GetDelegateForFunctionPointerTests.cs
@@ -10,6 +10,7 @@
 
 namespace System.Runtime.InteropServices.Tests
 {
+    [ActiveIssue("https://github.com/dotnet/runtime/issues/39187", TestPlatforms.Browser)]
     public class GetDelegateForFunctionPointerTests
     {
         [Theory]
diff --git a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/GetFunctionPointerForDelegateTests.cs b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/GetFunctionPointerForDelegateTests.cs
index 70204afc8897ae..c9e7cd925e6b6c 100644
--- a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/GetFunctionPointerForDelegateTests.cs
+++ b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/GetFunctionPointerForDelegateTests.cs
@@ -23,6 +23,7 @@ public void GetFunctionPointerForDelegate_NormalDelegateNonGeneric_ReturnsExpect
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/39187", TestPlatforms.Browser)]
         public void GetFunctionPointerForDelegate_MarshalledDelegateNonGeneric_ReturnsExpected()
         {
             MethodInfo targetMethod = typeof(GetFunctionPointerForDelegateTests).GetMethod(nameof(Method), BindingFlags.NonPublic | BindingFlags.Static);
@@ -51,6 +52,7 @@ public void GetFunctionPointerForDelegate_NormalDelegateGeneric_ReturnsExpected(
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/39187", TestPlatforms.Browser)]
         public void GetFunctionPointerForDelegate_MarshalledDelegateGeneric_ReturnsExpected()
         {
             MethodInfo targetMethod = typeof(GetFunctionPointerForDelegateTests).GetMethod(nameof(Method), BindingFlags.NonPublic | BindingFlags.Static);
diff --git a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
index df8381a578e149..5ed3fd5313c629 100644
--- a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
+++ b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
@@ -109,7 +109,7 @@ public void OffsetOf_Decimal_ReturnsExpected()
         {
             Type t = typeof(FieldAlignmentTest_Decimal);
 
-            if (RuntimeInformation.IsOSPlatform(OSPlatform.Windows) || (RuntimeInformation.ProcessArchitecture != Architecture.X86))
+            if (RuntimeInformation.IsOSPlatform(OSPlatform.Windows) || (RuntimeInformation.ProcessArchitecture != Architecture.X86 && RuntimeInformation.ProcessArchitecture != Architecture.Wasm))
             {
                 Assert.Equal(96, Marshal.SizeOf(t));
             }
@@ -121,7 +121,7 @@ public void OffsetOf_Decimal_ReturnsExpected()
             Assert.Equal(new IntPtr(0), Marshal.OffsetOf(t, nameof(FieldAlignmentTest_Decimal.b)));
             Assert.Equal(new IntPtr(8), Marshal.OffsetOf(t, nameof(FieldAlignmentTest_Decimal.p)));
 
-            if (RuntimeInformation.IsOSPlatform(OSPlatform.Windows) || (RuntimeInformation.ProcessArchitecture != Architecture.X86))
+            if (RuntimeInformation.IsOSPlatform(OSPlatform.Windows) || (RuntimeInformation.ProcessArchitecture != Architecture.X86 && RuntimeInformation.ProcessArchitecture != Architecture.Wasm))
             {
                 Assert.Equal(new IntPtr(88), Marshal.OffsetOf(t, nameof(FieldAlignmentTest_Decimal.s)));
             }
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index 3eadd269caeba6..4b982f4f7cc708 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -58,7 +58,6 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Resources.Extensions\tests\System.Resources.Extensions.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Resources.Reader\tests\System.Resources.Reader.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Resources.ResourceManager\tests\System.Resources.ResourceManager.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.InteropServices\tests\System.Runtime.InteropServices.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Loader\tests\DefaultContext\System.Runtime.Loader.DefaultContext.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Loader\tests\System.Runtime.Loader.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Serialization.Json\tests\ReflectionOnly\System.Runtime.Serialization.Json.ReflectionOnly.Tests.csproj" />