diff --git a/src/libraries/System.Private.CoreLib/src/System/Numerics/Matrix4x4.cs b/src/libraries/System.Private.CoreLib/src/System/Numerics/Matrix4x4.cs
index c13f7e8132ed22..0b0e92e9577200 100644
--- a/src/libraries/System.Private.CoreLib/src/System/Numerics/Matrix4x4.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/Numerics/Matrix4x4.cs
@@ -1338,6 +1338,13 @@ public static unsafe bool Invert(Matrix4x4 matrix, out Matrix4x4 result)
 
             static unsafe bool SseImpl(Matrix4x4 matrix, out Matrix4x4 result)
             {
+                // Redundant test so we won't prejit remainder of this method
+                // on platforms without SSE.
+                if (!Sse.IsSupported)
+                {
+                    throw new PlatformNotSupportedException();
+                }
+
                 // This implementation is based on the DirectX Math Library XMMInverse method
                 // https://github.com/microsoft/DirectXMath/blob/master/Inc/DirectXMathMatrix.inl