diff --git a/src/coreclr/tools/r2rtest/CompilerRunner.cs b/src/coreclr/tools/r2rtest/CompilerRunner.cs
index aff944bf05ef1b..fec6ce83cf0089 100644
--- a/src/coreclr/tools/r2rtest/CompilerRunner.cs
+++ b/src/coreclr/tools/r2rtest/CompilerRunner.cs
@@ -31,6 +31,7 @@ public sealed class FrameworkExclusion
         {
             new FrameworkExclusion(ExclusionType.Ignore, "CommandLine", "Not a framework assembly"),
             new FrameworkExclusion(ExclusionType.Ignore, "R2RDump", "Not a framework assembly"),
+            new FrameworkExclusion(ExclusionType.Ignore, "System.TestStructs", "Not a framework assembly"),
 
             // TODO (DavidWr): IBC-related failures
             new FrameworkExclusion(ExclusionType.DontCrossgen2, "Microsoft.CodeAnalysis.CSharp", "Ibc TypeToken 6200019a has type token which resolves to a nil token"),