diff --git a/src/libraries/System.Configuration.ConfigurationManager/src/System.Configuration.ConfigurationManager.csproj b/src/libraries/System.Configuration.ConfigurationManager/src/System.Configuration.ConfigurationManager.csproj
index 574ed1ed373959..e9b42f71375f55 100644
--- a/src/libraries/System.Configuration.ConfigurationManager/src/System.Configuration.ConfigurationManager.csproj
+++ b/src/libraries/System.Configuration.ConfigurationManager/src/System.Configuration.ConfigurationManager.csproj
@@ -1,6 +1,8 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
     <TargetFrameworks>netstandard2.0;net461</TargetFrameworks>
+    <!-- opt-out of trimming until it works https://github.com/dotnet/runtime/issues/49062 -->
+    <SetIsTrimmable>false</SetIsTrimmable>
   </PropertyGroup>
   <!-- DesignTimeBuild requires all the TargetFramework Derived Properties to not be present in the first property group. -->
   <PropertyGroup>