diff --git a/src/libraries/System.Net.Sockets/tests/FunctionalTests/SendFile.cs b/src/libraries/System.Net.Sockets/tests/FunctionalTests/SendFile.cs
index cda5d75b48c303..aa0d967e9f783d 100644
--- a/src/libraries/System.Net.Sockets/tests/FunctionalTests/SendFile.cs
+++ b/src/libraries/System.Net.Sockets/tests/FunctionalTests/SendFile.cs
@@ -235,45 +235,6 @@ public async Task SliceBuffers_Success()
             }
         }
 
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/42534", TestPlatforms.Windows)]
-        [OuterLoop("Creates and sends a file several gigabytes long")]
-        [Fact]
-        public async Task GreaterThan2GBFile_SendsAllBytes()
-        {
-            const long FileLength = 100L + int.MaxValue;
-
-            using var tmpFile = TempFile.Create();
-            using (FileStream fs = File.Create(tmpFile.Path))
-            {
-                fs.SetLength(FileLength);
-            }
-
-            using var client = new Socket(AddressFamily.InterNetwork, SocketType.Stream, ProtocolType.Tcp);
-            using var listener = new Socket(AddressFamily.InterNetwork, SocketType.Stream, ProtocolType.Tcp);
-            listener.BindToAnonymousPort(IPAddress.Loopback);
-            listener.Listen(1);
-
-            client.Connect(listener.LocalEndPoint);
-            using Socket server = listener.Accept();
-
-            await new Task[]
-            {
-                SendFileAsync(server, tmpFile.Path),
-                Task.Run(() =>
-                {
-                    byte[] buffer = new byte[100_000];
-                    long count = 0;
-                    while (count < FileLength)
-                    {
-                        int received = client.Receive(buffer);
-                        Assert.NotEqual(0, received);
-                        count += received;
-                    }
-                    Assert.Equal(0, client.Available);
-                })
-            }.WhenAllOrAnyFailed();
-        }
-
         [Fact]
         public async Task SendFileGetsCanceledByDispose()
         {
@@ -503,4 +464,78 @@ public void EndSendFile_NullAsyncResult_Throws()
             Assert.Throws<ArgumentNullException>(() => s.EndSendFile(null));
         }
     }
+
+    // Running all cases of GreaterThan2GBFile_SendsAllBytes in parallel may attempt to allocate Min(ProcessorCount, Subclass_Count) * 2GB of disk space
+    // in extreme cases. Some CI machines may run out of disk space if this happens.
+    [Collection(nameof(NoParallelTests))]
+    public abstract class SendFile_NonParallel<T> : SocketTestHelperBase<T> where T : SocketHelperBase, new()
+    {
+        protected SendFile_NonParallel(ITestOutputHelper output) : base(output)
+        {
+        }
+
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/42534", TestPlatforms.Windows)]
+        [OuterLoop("Creates and sends a file several gigabytes long")]
+        [Fact]
+        public async Task GreaterThan2GBFile_SendsAllBytes()
+        {
+            const long FileLength = 100L + int.MaxValue;
+
+            using var tmpFile = TempFile.Create();
+            using (FileStream fs = File.Create(tmpFile.Path))
+            {
+                fs.SetLength(FileLength);
+            }
+
+            using var client = new Socket(AddressFamily.InterNetwork, SocketType.Stream, ProtocolType.Tcp);
+            using var listener = new Socket(AddressFamily.InterNetwork, SocketType.Stream, ProtocolType.Tcp);
+            listener.BindToAnonymousPort(IPAddress.Loopback);
+            listener.Listen(1);
+
+            client.Connect(listener.LocalEndPoint);
+            using Socket server = listener.Accept();
+
+            await new Task[]
+            {
+                SendFileAsync(server, tmpFile.Path),
+                Task.Run(() =>
+                {
+                    byte[] buffer = new byte[100_000];
+                    long count = 0;
+                    while (count < FileLength)
+                    {
+                        int received = client.Receive(buffer);
+                        Assert.NotEqual(0, received);
+                        count += received;
+                    }
+                    Assert.Equal(0, client.Available);
+                })
+            }.WhenAllOrAnyFailed();
+        }
+    }
+
+    public sealed class SendFile_NonParallel_SyncSpan : SendFile_NonParallel<SocketHelperSpanSync>
+    {
+        public SendFile_NonParallel_SyncSpan(ITestOutputHelper output) : base(output) { }
+    }
+
+    public sealed class SendFile_NonParallel_SyncSpanForceNonBlocking : SendFile_NonParallel<SocketHelperSpanSyncForceNonBlocking>
+    {
+        public SendFile_NonParallel_SyncSpanForceNonBlocking(ITestOutputHelper output) : base(output) { }
+    }
+
+    public sealed class SendFile_NonParallel_ArraySync : SendFile_NonParallel<SocketHelperArraySync>
+    {
+        public SendFile_NonParallel_ArraySync(ITestOutputHelper output) : base(output) { }
+    }
+
+    public sealed class SendFile_NonParallel_Task : SendFile_NonParallel<SocketHelperTask>
+    {
+        public SendFile_NonParallel_Task(ITestOutputHelper output) : base(output) { }
+    }
+
+    public sealed class SendFile_NonParallel_Apm : SendFile_NonParallel<SocketHelperApm>
+    {
+        public SendFile_NonParallel_Apm(ITestOutputHelper output) : base(output) { }
+    }
 }