diff --git a/src/coreclr/gc/gcpriv.h b/src/coreclr/gc/gcpriv.h
index 0dfae746e10d3f..d36dc0a755a789 100644
--- a/src/coreclr/gc/gcpriv.h
+++ b/src/coreclr/gc/gcpriv.h
@@ -51,8 +51,8 @@ inline void FATAL_GC_ERROR()
 //
 // This means any empty regions can be freely used for any generation. For
 // Server GC we will balance regions between heaps.
-// For now disable regions outside of StandAlone GC builds
-#if defined (HOST_64BIT) && defined (BUILD_AS_STANDALONE)
+// For now disable regions for StandAlone GC, NativeAOT and MacOS builds
+#if defined (HOST_64BIT) && !defined (BUILD_AS_STANDALONE) && !defined(__APPLE__) && !defined(FEATURE_REDHAWK)
 #define USE_REGIONS
 #endif //HOST_64BIT && BUILD_AS_STANDALONE