diff --git a/src/coreclr/scripts/superpmi_replay.py b/src/coreclr/scripts/superpmi_replay.py
index 198b0f28ff9403..76adc8c51c9bdb 100644
--- a/src/coreclr/scripts/superpmi_replay.py
+++ b/src/coreclr/scripts/superpmi_replay.py
@@ -26,11 +26,13 @@
 
 jit_flags = [
     "JitStressRegs=0",
-    "JitStressRegs=1",
+    # JitStressRegs=1 disabled due to https://github.com/dotnet/runtime/issues/65332
+    # "JitStressRegs=1",
     "JitStressRegs=2",
     "JitStressRegs=3",
     "JitStressRegs=4",
-    "JitStressRegs=8",
+    # JitStressRegs=8 disabled due to https://github.com/dotnet/runtime/issues/65332
+    # "JitStressRegs=8",
     "JitStressRegs=0x10",
     "JitStressRegs=0x80",
     "JitStressRegs=0x1000",