diff --git a/src/libraries/Common/tests/TestUtilities/System/IO/FileCleanupTestBase.cs b/src/libraries/Common/tests/TestUtilities/System/IO/FileCleanupTestBase.cs
index 0ef72bf88ef53e..8c576ab24a078e 100644
--- a/src/libraries/Common/tests/TestUtilities/System/IO/FileCleanupTestBase.cs
+++ b/src/libraries/Common/tests/TestUtilities/System/IO/FileCleanupTestBase.cs
@@ -163,7 +163,7 @@ protected static string GetNamedPipeServerStreamName()
                 return Guid.NewGuid().ToString("N");
             }
 
-            if (!PlatformDetection.IsCaseSensitiveOS)
+            if (!PlatformDetection.FileCreateCaseSensitive)
             {
                 return $"/tmp/{Guid.NewGuid().ToString("N")}";
             }
diff --git a/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs b/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
index a8d0ad4a98e8ce..85d0d234cc6b18 100644
--- a/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
+++ b/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
@@ -82,12 +82,13 @@ public static partial class PlatformDetection
         public static int SlowRuntimeTimeoutModifier = (PlatformDetection.IsDebugRuntime ? 5 : 1);
 
         public static bool IsCaseInsensitiveOS => IsWindows || IsOSX || IsMacCatalyst;
+        public static bool IsCaseSensitiveOS => !IsCaseInsensitiveOS;
 
 #if NETCOREAPP
-        public static bool IsCaseSensitiveOS => !IsCaseInsensitiveOS && !RuntimeInformation.RuntimeIdentifier.StartsWith("iossimulator")
-                                                                     && !RuntimeInformation.RuntimeIdentifier.StartsWith("tvossimulator");
+        public static bool FileCreateCaseSensitive => IsCaseSensitiveOS && !RuntimeInformation.RuntimeIdentifier.StartsWith("iossimulator")
+                                                                        && !RuntimeInformation.RuntimeIdentifier.StartsWith("tvossimulator");
 #else
-        public static bool IsCaseSensitiveOS => !IsCaseInsensitiveOS;
+        public static bool FileCreateCaseSensitive => IsCaseSensitiveOS;
 #endif
 
         public static bool IsThreadingSupported => !IsBrowser;
diff --git a/src/libraries/System.IO.FileSystem/tests/Base/FileGetSetAttributes.cs b/src/libraries/System.IO.FileSystem/tests/Base/FileGetSetAttributes.cs
index 4a43aabfb574c8..20f92242d98bd1 100644
--- a/src/libraries/System.IO.FileSystem/tests/Base/FileGetSetAttributes.cs
+++ b/src/libraries/System.IO.FileSystem/tests/Base/FileGetSetAttributes.cs
@@ -62,7 +62,7 @@ public void SettingInvalidAttributes_Unix(FileAttributes attributes)
             AssertSettingInvalidAttributes(path, attributes);
         }
 
-        [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.IsCaseSensitiveOS))]
+        [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.FileCreateCaseSensitive))]
         [InlineData(FileAttributes.Hidden)]
         [PlatformSpecific(TestPlatforms.AnyUnix & ~(TestPlatforms.OSX | TestPlatforms.FreeBSD))]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/67853", TestPlatforms.tvOS)]
diff --git a/src/libraries/System.IO.FileSystem/tests/Directory/GetFileSystemEntries_str_str.cs b/src/libraries/System.IO.FileSystem/tests/Directory/GetFileSystemEntries_str_str.cs
index d76ebd54f9e6ba..7ccdc8bcb3f930 100644
--- a/src/libraries/System.IO.FileSystem/tests/Directory/GetFileSystemEntries_str_str.cs
+++ b/src/libraries/System.IO.FileSystem/tests/Directory/GetFileSystemEntries_str_str.cs
@@ -697,7 +697,7 @@ public void WindowsSearchPatternWhitespace()
             Assert.Empty(GetEntries(TestDirectory, "\t"));
         }
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsCaseSensitiveOS))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.FileCreateCaseSensitive))]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/67853", TestPlatforms.tvOS)]
         public void SearchPatternCaseSensitive()
         {
diff --git a/src/libraries/System.IO.FileSystem/tests/File/Create.cs b/src/libraries/System.IO.FileSystem/tests/File/Create.cs
index 4a01cd24e54302..7a5eacea6322fd 100644
--- a/src/libraries/System.IO.FileSystem/tests/File/Create.cs
+++ b/src/libraries/System.IO.FileSystem/tests/File/Create.cs
@@ -217,7 +217,7 @@ public void LongFileName()
             Assert.False(File.Exists(path));
         }
 
-        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsCaseSensitiveOS))]
+        [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.FileCreateCaseSensitive))]
         public void CaseSensitive()
         {
             DirectoryInfo testDir = Directory.CreateDirectory(GetTestFilePath());
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
index 24f763de070595..b303f1e5d6f9ea 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
@@ -811,9 +811,8 @@ public static void GetPermissionSet()
 #pragma warning restore SYSLIB0003 // Obsolete: CAS
         }
 
-        [Theory]
+        [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.FileCreateCaseSensitive))]
         [MemberData(nameof(TestingCreateInstanceFromObjectHandleData))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/65560", TestPlatforms.iOS | TestPlatforms.tvOS)]
         public static void TestingCreateInstanceFromObjectHandle(string physicalFileName, string assemblyFile, string type, string returnedFullNameType, Type exceptionType)
         {
             ObjectHandle oh = null;