diff --git a/eng/Version.Details.xml b/eng/Version.Details.xml
index 91169fa67..759e133da 100644
--- a/eng/Version.Details.xml
+++ b/eng/Version.Details.xml
@@ -1,10 +1,6 @@
 <?xml version="1.0" encoding="utf-8"?>
 <Dependencies>
   <ProductDependencies>
-    <Dependency Name="Microsoft.NETCore.App" Version="5.0.0-rtm.20529.3">
-      <Uri>https://github.com/dotnet/runtime</Uri>
-      <Sha>7ef6d50b312217d2f7c17b9697891fa8ab98a19d</Sha>
-    </Dependency>
   </ProductDependencies>
   <ToolsetDependencies>
     <Dependency Name="Microsoft.DotNet.Arcade.Sdk" Version="6.0.0-beta.21264.2">
diff --git a/eng/Versions.props b/eng/Versions.props
index 44ba525f8..e20540995 100644
--- a/eng/Versions.props
+++ b/eng/Versions.props
@@ -9,8 +9,4 @@
     -->
     <PreReleaseVersionLabel>preview.12</PreReleaseVersionLabel>
   </PropertyGroup>
-  <!--Package versions-->
-  <PropertyGroup>
-    <MicrosoftNETCoreAppPackageVersion>5.0.0-rtm.20529.3</MicrosoftNETCoreAppPackageVersion>
-  </PropertyGroup>
 </Project>
diff --git a/global.json b/global.json
index 25fc148ea..641803045 100644
--- a/global.json
+++ b/global.json
@@ -1,12 +1,11 @@
 {
   "sdk": {
-    "version": "6.0.100-preview.3.21202.5"
+    "version": "6.0.100-preview.6.21271.8"
   },
   "tools": {
-    "dotnet": "6.0.100-preview.3.21202.5",
+    "dotnet": "6.0.100-preview.6.21271.8",
     "runtimes": {
       "dotnet": [
-        "$(MicrosoftNETCoreAppPackageVersion)",
         "3.1.14",
         "5.0.5"
       ],
diff --git a/samples/BasicYarpSample/BasicYarpSample.csproj b/samples/BasicYarpSample/BasicYarpSample.csproj
index b3ced3760..1d0de6612 100644
--- a/samples/BasicYarpSample/BasicYarpSample.csproj
+++ b/samples/BasicYarpSample/BasicYarpSample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFramework>net5.0</TargetFramework>
+    <TargetFrameworks>net6.0;net5.0</TargetFrameworks>
     <LangVersion>latest</LangVersion>
   </PropertyGroup>
 
diff --git a/samples/Prometheus/ReverseProxy.Metrics-Promethius.Sample/ReverseProxy.Metrics.Promethius.Sample.csproj b/samples/Prometheus/ReverseProxy.Metrics-Promethius.Sample/ReverseProxy.Metrics.Promethius.Sample.csproj
index 745977627..5fcd62218 100644
--- a/samples/Prometheus/ReverseProxy.Metrics-Promethius.Sample/ReverseProxy.Metrics.Promethius.Sample.csproj
+++ b/samples/Prometheus/ReverseProxy.Metrics-Promethius.Sample/ReverseProxy.Metrics.Promethius.Sample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.Sample</RootNamespace>
     <LangVersion>latest</LangVersion>
diff --git a/samples/ReverseProxy.Code.Sample/ReverseProxy.Code.Sample.csproj b/samples/ReverseProxy.Code.Sample/ReverseProxy.Code.Sample.csproj
index 0cf9595b7..010ee17e1 100644
--- a/samples/ReverseProxy.Code.Sample/ReverseProxy.Code.Sample.csproj
+++ b/samples/ReverseProxy.Code.Sample/ReverseProxy.Code.Sample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.Sample</RootNamespace>
     <LangVersion>latest</LangVersion>
diff --git a/samples/ReverseProxy.Config.Sample/ReverseProxy.Config.Sample.csproj b/samples/ReverseProxy.Config.Sample/ReverseProxy.Config.Sample.csproj
index 0cf9595b7..010ee17e1 100644
--- a/samples/ReverseProxy.Config.Sample/ReverseProxy.Config.Sample.csproj
+++ b/samples/ReverseProxy.Config.Sample/ReverseProxy.Config.Sample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.Sample</RootNamespace>
     <LangVersion>latest</LangVersion>
diff --git a/samples/ReverseProxy.ConfigFilter.Sample/ReverseProxy.ConfigFilter.Sample.csproj b/samples/ReverseProxy.ConfigFilter.Sample/ReverseProxy.ConfigFilter.Sample.csproj
index 0cf9595b7..010ee17e1 100644
--- a/samples/ReverseProxy.ConfigFilter.Sample/ReverseProxy.ConfigFilter.Sample.csproj
+++ b/samples/ReverseProxy.ConfigFilter.Sample/ReverseProxy.ConfigFilter.Sample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.Sample</RootNamespace>
     <LangVersion>latest</LangVersion>
diff --git a/samples/ReverseProxy.Direct.Sample/ReverseProxy.Direct.Sample.csproj b/samples/ReverseProxy.Direct.Sample/ReverseProxy.Direct.Sample.csproj
index 0cf9595b7..010ee17e1 100644
--- a/samples/ReverseProxy.Direct.Sample/ReverseProxy.Direct.Sample.csproj
+++ b/samples/ReverseProxy.Direct.Sample/ReverseProxy.Direct.Sample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.Sample</RootNamespace>
     <LangVersion>latest</LangVersion>
diff --git a/samples/ReverseProxy.Metrics.Sample/ReverseProxy.Metrics.Sample.csproj b/samples/ReverseProxy.Metrics.Sample/ReverseProxy.Metrics.Sample.csproj
index 5ba7dce09..b5af92627 100644
--- a/samples/ReverseProxy.Metrics.Sample/ReverseProxy.Metrics.Sample.csproj
+++ b/samples/ReverseProxy.Metrics.Sample/ReverseProxy.Metrics.Sample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.Sample</RootNamespace>
     <LangVersion>latest</LangVersion>
diff --git a/samples/ReverseProxy.ServiceFabric.Sample/ReverseProxy.ServiceFabric.Sample.csproj b/samples/ReverseProxy.ServiceFabric.Sample/ReverseProxy.ServiceFabric.Sample.csproj
index e7d57eec7..af48d7ee4 100644
--- a/samples/ReverseProxy.ServiceFabric.Sample/ReverseProxy.ServiceFabric.Sample.csproj
+++ b/samples/ReverseProxy.ServiceFabric.Sample/ReverseProxy.ServiceFabric.Sample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.Sample</RootNamespace>
     <PlatformTarget>x64</PlatformTarget>
diff --git a/samples/ReverseProxy.Transforms.Sample/ReverseProxy.Transforms.Sample.csproj b/samples/ReverseProxy.Transforms.Sample/ReverseProxy.Transforms.Sample.csproj
index 0cf9595b7..010ee17e1 100644
--- a/samples/ReverseProxy.Transforms.Sample/ReverseProxy.Transforms.Sample.csproj
+++ b/samples/ReverseProxy.Transforms.Sample/ReverseProxy.Transforms.Sample.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.Sample</RootNamespace>
     <LangVersion>latest</LangVersion>
diff --git a/test/ReverseProxy.FunctionalTests/Common/TestEnvironment.cs b/test/ReverseProxy.FunctionalTests/Common/TestEnvironment.cs
index 34c30a2bf..09020cc59 100644
--- a/test/ReverseProxy.FunctionalTests/Common/TestEnvironment.cs
+++ b/test/ReverseProxy.FunctionalTests/Common/TestEnvironment.cs
@@ -38,7 +38,7 @@ public TestEnvironment(
                   destinationServices => { },
                   destinationApp =>
                   {
-                      destinationApp.Use(async (context, next) => await destinationGetDelegate(context));
+                      destinationApp.Run(destinationGetDelegate);
                   },
                   configureProxy,
                   configureProxyApp,
diff --git a/test/ReverseProxy.FunctionalTests/Yarp.ReverseProxy.FunctionalTests.csproj b/test/ReverseProxy.FunctionalTests/Yarp.ReverseProxy.FunctionalTests.csproj
index 35df565e7..a1787c6ab 100644
--- a/test/ReverseProxy.FunctionalTests/Yarp.ReverseProxy.FunctionalTests.csproj
+++ b/test/ReverseProxy.FunctionalTests/Yarp.ReverseProxy.FunctionalTests.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Library</OutputType>
     <RootNamespace>Yarp.ReverseProxy</RootNamespace>
   </PropertyGroup>
diff --git a/test/ReverseProxy.Kubernetes.Tests/Yarp.ReverseProxy.Kubernetes.Tests.csproj b/test/ReverseProxy.Kubernetes.Tests/Yarp.ReverseProxy.Kubernetes.Tests.csproj
index 7ee0f8c87..33e8d169d 100644
--- a/test/ReverseProxy.Kubernetes.Tests/Yarp.ReverseProxy.Kubernetes.Tests.csproj
+++ b/test/ReverseProxy.Kubernetes.Tests/Yarp.ReverseProxy.Kubernetes.Tests.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Library</OutputType>
   </PropertyGroup>
 
diff --git a/test/ReverseProxy.ServiceFabric.Tests/Yarp.ReverseProxy.ServiceFabric.Tests.csproj b/test/ReverseProxy.ServiceFabric.Tests/Yarp.ReverseProxy.ServiceFabric.Tests.csproj
index 893c540ae..d01a077ae 100644
--- a/test/ReverseProxy.ServiceFabric.Tests/Yarp.ReverseProxy.ServiceFabric.Tests.csproj
+++ b/test/ReverseProxy.ServiceFabric.Tests/Yarp.ReverseProxy.ServiceFabric.Tests.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Library</OutputType>
     <RootNamespace>Yarp.ReverseProxy.ServiceFabric</RootNamespace>
     <PlatformTarget>x64</PlatformTarget>
diff --git a/test/ReverseProxy.Tests.Common/Yarp.ReverseProxy.Tests.Common.csproj b/test/ReverseProxy.Tests.Common/Yarp.ReverseProxy.Tests.Common.csproj
index fdeb1db01..aaa0d3f00 100644
--- a/test/ReverseProxy.Tests.Common/Yarp.ReverseProxy.Tests.Common.csproj
+++ b/test/ReverseProxy.Tests.Common/Yarp.ReverseProxy.Tests.Common.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Library</OutputType>
     <RootNamespace>Yarp.ReverseProxy</RootNamespace>
   </PropertyGroup>
diff --git a/test/ReverseProxy.Tests/Abstractions/ClusterDiscovery/Contract/ClusterTests.cs b/test/ReverseProxy.Tests/Abstractions/ClusterDiscovery/Contract/ClusterTests.cs
index 5eca5feb2..4339fb042 100644
--- a/test/ReverseProxy.Tests/Abstractions/ClusterDiscovery/Contract/ClusterTests.cs
+++ b/test/ReverseProxy.Tests/Abstractions/ClusterDiscovery/Contract/ClusterTests.cs
@@ -411,7 +411,8 @@ public void Cluster_CanBeJsonSerialized()
 
             var options = new JsonSerializerOptions
             {
-#if !NET6_0_OR_GREATER
+                // Future 6.0 builds will contain the fix to these missing converters
+//#if !NET6_0_OR_GREATER
                 Converters =
                 {
                     // TimeSpans https://github.com/dotnet/runtime/issues/29932
@@ -419,7 +420,7 @@ public void Cluster_CanBeJsonSerialized()
                     // Version https://github.com/dotnet/runtime/pull/41384
                     new VersionConverter()
                 }
-#endif
+//#endif
             };
             var json = JsonSerializer.Serialize(cluster1, options);
             var cluster2 = JsonSerializer.Deserialize<ClusterConfig>(json, options);
diff --git a/test/ReverseProxy.Tests/Yarp.ReverseProxy.Tests.csproj b/test/ReverseProxy.Tests/Yarp.ReverseProxy.Tests.csproj
index daaa8290b..f3f358c5a 100644
--- a/test/ReverseProxy.Tests/Yarp.ReverseProxy.Tests.csproj
+++ b/test/ReverseProxy.Tests/Yarp.ReverseProxy.Tests.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Library</OutputType>
     <RootNamespace>Yarp.ReverseProxy</RootNamespace>
   </PropertyGroup>
diff --git a/testassets/BenchmarkApp/BenchmarkApp.csproj b/testassets/BenchmarkApp/BenchmarkApp.csproj
index ffdf6fe88..c7067f1f9 100644
--- a/testassets/BenchmarkApp/BenchmarkApp.csproj
+++ b/testassets/BenchmarkApp/BenchmarkApp.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
   </PropertyGroup>
 
   <ItemGroup>
diff --git a/testassets/ReverseProxy.Code/ReverseProxy.Code.csproj b/testassets/ReverseProxy.Code/ReverseProxy.Code.csproj
index 83e9596e1..2334126b4 100644
--- a/testassets/ReverseProxy.Code/ReverseProxy.Code.csproj
+++ b/testassets/ReverseProxy.Code/ReverseProxy.Code.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.ReverseProxy.Sample</RootNamespace>
   </PropertyGroup>
diff --git a/testassets/ReverseProxy.Config/ReverseProxy.Config.csproj b/testassets/ReverseProxy.Config/ReverseProxy.Config.csproj
index f5e6e4aed..f2b621780 100644
--- a/testassets/ReverseProxy.Config/ReverseProxy.Config.csproj
+++ b/testassets/ReverseProxy.Config/ReverseProxy.Config.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.ReverseProxy.Sample</RootNamespace>
   </PropertyGroup>
diff --git a/testassets/ReverseProxy.Direct/ReverseProxy.Direct.csproj b/testassets/ReverseProxy.Direct/ReverseProxy.Direct.csproj
index f5e6e4aed..f2b621780 100644
--- a/testassets/ReverseProxy.Direct/ReverseProxy.Direct.csproj
+++ b/testassets/ReverseProxy.Direct/ReverseProxy.Direct.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFrameworks>net5.0;netcoreapp3.1</TargetFrameworks>
+    <TargetFrameworks>net6.0;net5.0;netcoreapp3.1</TargetFrameworks>
     <OutputType>Exe</OutputType>
     <RootNamespace>Yarp.ReverseProxy.Sample</RootNamespace>
   </PropertyGroup>
diff --git a/testassets/TestClient/TestClient.csproj b/testassets/TestClient/TestClient.csproj
index f6f12fbea..04bfb5515 100644
--- a/testassets/TestClient/TestClient.csproj
+++ b/testassets/TestClient/TestClient.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFramework>net5.0</TargetFramework>
+    <TargetFramework>net6.0</TargetFramework>
     <OutputType>Exe</OutputType>
   </PropertyGroup>
 
diff --git a/testassets/TestServer/TestServer.csproj b/testassets/TestServer/TestServer.csproj
index ee7abf0d4..4e0101aef 100644
--- a/testassets/TestServer/TestServer.csproj
+++ b/testassets/TestServer/TestServer.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk.Web">
 
   <PropertyGroup>
-    <TargetFramework>net5.0</TargetFramework>
+    <TargetFramework>net6.0</TargetFramework>
     <OutputType>Exe</OutputType>
     <RootNamespace>SampleServer</RootNamespace>
   </PropertyGroup>