diff --git a/test/core/test_stdio_locking.c b/test/core/test_stdio_locking.c
index 538c157e36236..e57edb494d40b 100644
--- a/test/core/test_stdio_locking.c
+++ b/test/core/test_stdio_locking.c
@@ -9,31 +9,69 @@
  *   musl/src/stdio/fwrite.c
  */
 #include <assert.h>
-#include <pthread.h>
 #include <stdio.h>
-#include <string.h>
 #include <stdlib.h>
+#include <string.h>
+
+#ifndef __wasm_atomics__
+#error Expected to be compiled with -matomics.
+#endif
+
+#ifndef __wasm_bulk_memory__
+#error Expected to be compiled with -mbulk-memory.
+#endif
+
+#ifdef __EMSCRIPTEN_WASM_WORKERS__
+#include <emscripten/eventloop.h>
+#include <emscripten/wasm_worker.h>
+
+emscripten_wasm_worker_t worker[2];
+
+void terminate_worker(void* userData) {
+  emscripten_terminate_all_wasm_workers();
+  printf("main done\n");
+}
+#elif defined(__EMSCRIPTEN_PTHREADS__)
+#include <pthread.h>
 
 pthread_t thread[2];
 
-char *char_repeat(int n, char c) {
-  char *dest = malloc(n + 1);
+void thread_func(void);
+
+void* thread_main(void* arg) {
+  thread_func();
+  return 0;
+}
+#else
+#error Expected to be compiled with either -sWASM_WORKERS or -pthread.
+#endif
+
+char* char_repeat(int n, char c) {
+  char* dest = malloc(n + 1);
   memset(dest, c, n);
   dest[n] = '\0';
   return dest;
 }
 
-void *thread_main(void *arg) {
-  char *msg = char_repeat(100, 'a');
+void thread_func(void) {
+  char* msg = char_repeat(100, 'a');
   for (int i = 0; i < 10; ++i)
-  printf("%s\n", msg);
+    printf("%s\n", msg);
   free(msg);
-  return 0;
 }
 
 int main() {
   printf("in main\n");
-  void *thread_rtn;
+#ifdef __EMSCRIPTEN_WASM_WORKERS__
+  worker[0] = emscripten_malloc_wasm_worker(/*stack size: */ 1024);
+  worker[1] = emscripten_malloc_wasm_worker(/*stack size: */ 1024);
+  emscripten_wasm_worker_post_function_v(worker[0], thread_func);
+  emscripten_wasm_worker_post_function_v(worker[1], thread_func);
+
+  // Terminate both workers after a small delay
+  emscripten_set_timeout(terminate_worker, 1000, 0);
+#else
+  void* thread_rtn;
   int rc;
 
   rc = pthread_create(&thread[0], NULL, thread_main, NULL);
@@ -51,5 +89,6 @@ int main() {
   assert(thread_rtn == 0);
 
   printf("main done\n");
+#endif
   return 0;
 }
diff --git a/test/test_core.py b/test/test_core.py
index c517d88fb4552..a26fd397d1519 100644
--- a/test/test_core.py
+++ b/test/test_core.py
@@ -9242,6 +9242,7 @@ def test_emscripten_futexes(self):
     self.do_core_test('pthread/emscripten_futexes.c', cflags=['-pthread', '-Wno-nonnull'])
 
   @requires_pthreads
+  @also_with_wasm_workers
   def test_stdio_locking(self):
     self.set_setting('PTHREAD_POOL_SIZE', '2')
     self.do_core_test('test_stdio_locking.c')