diff --git a/include/nighthawk/client/client_worker.h b/include/nighthawk/client/client_worker.h
index ecb651dca..ad234aa72 100644
--- a/include/nighthawk/client/client_worker.h
+++ b/include/nighthawk/client/client_worker.h
@@ -34,6 +34,11 @@ class ClientWorker : virtual public Worker {
    * @return const Phase& associated to this worker.
    */
   virtual const Phase& phase() const PURE;
+
+  /**
+   * Requests execution cancellation.
+   */
+  virtual void requestExecutionCancellation() PURE;
 };
 
 using ClientWorkerPtr = std::unique_ptr<ClientWorker>;
diff --git a/include/nighthawk/client/process.h b/include/nighthawk/client/process.h
index 39c214e4c..943517726 100644
--- a/include/nighthawk/client/process.h
+++ b/include/nighthawk/client/process.h
@@ -23,6 +23,11 @@ class Process {
    * Shuts down the worker. Mandatory call before destructing.
    */
   virtual void shutdown() PURE;
+
+  /**
+   * Will request all workers to cancel execution asap.
+   */
+  virtual bool requestExecutionCancellation() PURE;
 };
 
 using ProcessPtr = std::unique_ptr<Process>;
diff --git a/source/client/client.cc b/source/client/client.cc
index cd3b46743..8c08eda00 100644
--- a/source/client/client.cc
+++ b/source/client/client.cc
@@ -23,6 +23,7 @@
 #include "api/client/service.grpc.pb.h"
 
 #include "common/frequency.h"
+#include "common/signal_handler.h"
 #include "common/uri_impl.h"
 #include "common/utility.h"
 
@@ -73,16 +74,21 @@ bool Main::run() {
   }
   OutputFormatterFactoryImpl output_formatter_factory;
   OutputCollectorImpl output_collector(time_system, *options_);
-  const bool res = process->run(output_collector);
+  bool result;
+  {
+    auto signal_handler =
+        std::make_unique<SignalHandler>([&process]() { process->requestExecutionCancellation(); });
+    result = process->run(output_collector);
+  }
   auto formatter = output_formatter_factory.create(options_->outputFormat());
   std::cout << formatter->formatProto(output_collector.toProto());
   process->shutdown();
-  if (!res) {
+  if (!result) {
     ENVOY_LOG(error, "An error ocurred.");
   } else {
     ENVOY_LOG(info, "Done.");
   }
-  return res;
+  return result;
 }
 
 } // namespace Client
diff --git a/source/client/client_worker_impl.cc b/source/client/client_worker_impl.cc
index e4231bc87..09aaba66a 100644
--- a/source/client/client_worker_impl.cc
+++ b/source/client/client_worker_impl.cc
@@ -87,6 +87,14 @@ void ClientWorkerImpl::work() {
 
 void ClientWorkerImpl::shutdownThread() { benchmark_client_->terminate(); }
 
+void ClientWorkerImpl::requestExecutionCancellation() {
+  // We just bump a counter, which is watched by a static termination predicate.
+  // A useful side effect is that this counter will propagate to the output, which leaves
+  // a note about that execution was subject to cancellation.
+  dispatcher_->post(
+      [this]() { worker_number_scope_->counterFromString("graceful_stop_requested").inc(); });
+}
+
 StatisticPtrMap ClientWorkerImpl::statistics() const {
   StatisticPtrMap statistics;
   StatisticPtrMap s1 = benchmark_client_->statistics();
diff --git a/source/client/client_worker_impl.h b/source/client/client_worker_impl.h
index 05f2fcb35..41b2660bc 100644
--- a/source/client/client_worker_impl.h
+++ b/source/client/client_worker_impl.h
@@ -46,6 +46,8 @@ class ClientWorkerImpl : public WorkerImpl, virtual public ClientWorker {
 
   void shutdownThread() override;
 
+  void requestExecutionCancellation() override;
+
 protected:
   void work() override;
 
diff --git a/source/client/factories_impl.cc b/source/client/factories_impl.cc
index 0f63700b8..a2e3eb611 100644
--- a/source/client/factories_impl.cc
+++ b/source/client/factories_impl.cc
@@ -174,14 +174,18 @@ TerminationPredicateFactoryImpl::TerminationPredicateFactoryImpl(const Options&
 TerminationPredicatePtr
 TerminationPredicateFactoryImpl::create(Envoy::TimeSource& time_source, Envoy::Stats::Scope& scope,
                                         const Envoy::MonotonicTime scheduled_starting_time) const {
-  TerminationPredicatePtr root_predicate;
-  if (options_.noDuration()) {
-    root_predicate = std::make_unique<NullTerminationPredicateImpl>();
-  } else {
-    root_predicate = std::make_unique<DurationTerminationPredicateImpl>(
-        time_source, options_.duration(), scheduled_starting_time);
-  }
+  // We'll always link a predicate which checks for requests to cancel.
+  TerminationPredicatePtr root_predicate =
+      std::make_unique<StatsCounterAbsoluteThresholdTerminationPredicateImpl>(
+          scope.counterFromString("graceful_stop_requested"), 0,
+          TerminationPredicate::Status::TERMINATE);
+
   TerminationPredicate* current_predicate = root_predicate.get();
+  if (!options_.noDuration()) {
+    current_predicate = &current_predicate->link(std::make_unique<DurationTerminationPredicateImpl>(
+        time_source, options_.duration(), scheduled_starting_time));
+  }
+
   current_predicate = linkConfiguredPredicates(*current_predicate, options_.failurePredicates(),
                                                TerminationPredicate::Status::FAIL, scope);
   linkConfiguredPredicates(*current_predicate, options_.terminationPredicates(),
diff --git a/source/client/process_impl.cc b/source/client/process_impl.cc
index 311ef938f..85799d723 100644
--- a/source/client/process_impl.cc
+++ b/source/client/process_impl.cc
@@ -126,11 +126,15 @@ void ProcessImpl::shutdown() {
   // Before we shut down the worker threads, stop threading.
   tls_.shutdownGlobalThreading();
   store_root_.shutdownThreading();
-  // Before shutting down the cluster manager, stop the workers.
-  for (auto& worker : workers_) {
-    worker->shutdown();
+
+  {
+    auto guard = std::make_unique<Envoy::Thread::LockGuard>(workers_lock_);
+    // Before shutting down the cluster manager, stop the workers.
+    for (auto& worker : workers_) {
+      worker->shutdown();
+    }
+    workers_.clear();
   }
-  workers_.clear();
   if (cluster_manager_ != nullptr) {
     cluster_manager_->shutdown();
   }
@@ -138,7 +142,17 @@ void ProcessImpl::shutdown() {
   shutdown_ = true;
 }
 
-const std::vector<ClientWorkerPtr>& ProcessImpl::createWorkers(const uint32_t concurrency) {
+bool ProcessImpl::requestExecutionCancellation() {
+  ENVOY_LOG(debug, "Requesting workers to cancel execution");
+  auto guard = std::make_unique<Envoy::Thread::LockGuard>(workers_lock_);
+  for (auto& worker : workers_) {
+    worker->requestExecutionCancellation();
+  }
+  cancelled_ = true;
+  return true;
+}
+
+void ProcessImpl::createWorkers(const uint32_t concurrency) {
   // TODO(oschaaf): Expose kMinimalDelay in configuration.
   const std::chrono::milliseconds kMinimalWorkerDelay = 500ms + (concurrency * 50ms);
   ASSERT(workers_.empty());
@@ -168,7 +182,6 @@ const std::vector<ClientWorkerPtr>& ProcessImpl::createWorkers(const uint32_t co
                                 : ClientWorkerImpl::HardCodedWarmupStyle::OFF));
     worker_number++;
   }
-  return workers_;
 }
 
 void ProcessImpl::configureComponentLogLevels(spdlog::level::level_enum level) {
@@ -381,44 +394,50 @@ void ProcessImpl::addRequestSourceCluster(
 
 bool ProcessImpl::runInternal(OutputCollector& collector, const std::vector<UriPtr>& uris,
                               const UriPtr& request_source_uri, const UriPtr& tracing_uri) {
-  int number_of_workers = determineConcurrency();
-  shutdown_ = false;
-  const std::vector<ClientWorkerPtr>& workers = createWorkers(number_of_workers);
-  tls_.registerThread(*dispatcher_, true);
-  store_root_.initializeThreading(*dispatcher_, tls_);
-  runtime_singleton_ = std::make_unique<Envoy::Runtime::ScopedLoaderSingleton>(
-      Envoy::Runtime::LoaderPtr{new Envoy::Runtime::LoaderImpl(
-          *dispatcher_, tls_, {}, *local_info_, store_root_, generator_,
-          Envoy::ProtobufMessage::getStrictValidationVisitor(), *api_)});
-  ssl_context_manager_ =
-      std::make_unique<Extensions::TransportSockets::Tls::ContextManagerImpl>(time_system_);
-  cluster_manager_factory_ = std::make_unique<ClusterManagerFactory>(
-      admin_, Envoy::Runtime::LoaderSingleton::get(), store_root_, tls_, generator_,
-      dispatcher_->createDnsResolver({}, false), *ssl_context_manager_, *dispatcher_, *local_info_,
-      secret_manager_, validation_context_, *api_, http_context_, grpc_context_,
-      access_log_manager_, *singleton_manager_);
-  cluster_manager_factory_->setConnectionReuseStrategy(
-      options_.h1ConnectionReuseStrategy() == nighthawk::client::H1ConnectionReuseStrategy::LRU
-          ? Http1PoolImpl::ConnectionReuseStrategy::LRU
-          : Http1PoolImpl::ConnectionReuseStrategy::MRU);
-  cluster_manager_factory_->setPrefetchConnections(options_.prefetchConnections());
-  envoy::config::bootstrap::v3::Bootstrap bootstrap;
-  createBootstrapConfiguration(bootstrap, uris, request_source_uri, number_of_workers);
-  if (tracing_uri != nullptr) {
-    setupTracingImplementation(bootstrap, *tracing_uri);
-    addTracingCluster(bootstrap, *tracing_uri);
-  }
-  ENVOY_LOG(debug, "Computed configuration: {}", bootstrap.DebugString());
-  cluster_manager_ = cluster_manager_factory_->clusterManagerFromProto(bootstrap);
-  maybeCreateTracingDriver(bootstrap.tracing());
-  cluster_manager_->setInitializedCb([this]() -> void { init_manager_.initialize(init_watcher_); });
+  {
+    auto guard = std::make_unique<Envoy::Thread::LockGuard>(workers_lock_);
+    if (cancelled_) {
+      return true;
+    }
+    int number_of_workers = determineConcurrency();
+    shutdown_ = false;
+    createWorkers(number_of_workers);
+    tls_.registerThread(*dispatcher_, true);
+    store_root_.initializeThreading(*dispatcher_, tls_);
+    runtime_singleton_ = std::make_unique<Envoy::Runtime::ScopedLoaderSingleton>(
+        Envoy::Runtime::LoaderPtr{new Envoy::Runtime::LoaderImpl(
+            *dispatcher_, tls_, {}, *local_info_, store_root_, generator_,
+            Envoy::ProtobufMessage::getStrictValidationVisitor(), *api_)});
+    ssl_context_manager_ =
+        std::make_unique<Extensions::TransportSockets::Tls::ContextManagerImpl>(time_system_);
+    cluster_manager_factory_ = std::make_unique<ClusterManagerFactory>(
+        admin_, Envoy::Runtime::LoaderSingleton::get(), store_root_, tls_, generator_,
+        dispatcher_->createDnsResolver({}, false), *ssl_context_manager_, *dispatcher_,
+        *local_info_, secret_manager_, validation_context_, *api_, http_context_, grpc_context_,
+        access_log_manager_, *singleton_manager_);
+    cluster_manager_factory_->setConnectionReuseStrategy(
+        options_.h1ConnectionReuseStrategy() == nighthawk::client::H1ConnectionReuseStrategy::LRU
+            ? Http1PoolImpl::ConnectionReuseStrategy::LRU
+            : Http1PoolImpl::ConnectionReuseStrategy::MRU);
+    cluster_manager_factory_->setPrefetchConnections(options_.prefetchConnections());
+    envoy::config::bootstrap::v3::Bootstrap bootstrap;
+    createBootstrapConfiguration(bootstrap, uris, request_source_uri, number_of_workers);
+    if (tracing_uri != nullptr) {
+      setupTracingImplementation(bootstrap, *tracing_uri);
+      addTracingCluster(bootstrap, *tracing_uri);
+    }
+    ENVOY_LOG(debug, "Computed configuration: {}", bootstrap.DebugString());
+    cluster_manager_ = cluster_manager_factory_->clusterManagerFromProto(bootstrap);
+    maybeCreateTracingDriver(bootstrap.tracing());
+    cluster_manager_->setInitializedCb(
+        [this]() -> void { init_manager_.initialize(init_watcher_); });
 
-  Runtime::LoaderSingleton::get().initialize(*cluster_manager_);
+    Runtime::LoaderSingleton::get().initialize(*cluster_manager_);
 
-  for (auto& w : workers_) {
-    w->start();
+    for (auto& w : workers_) {
+      w->start();
+    }
   }
-
   for (auto& w : workers_) {
     w->waitForCompletion();
   }
@@ -447,7 +466,7 @@ bool ProcessImpl::runInternal(OutputCollector& collector, const std::vector<UriP
   const auto& counters = Utility().mapCountersFromStore(
       store_root_, [](absl::string_view, uint64_t value) { return value > 0; });
   StatisticFactoryImpl statistic_factory(options_);
-  collector.addResult("global", mergeWorkerStatistics(workers), counters,
+  collector.addResult("global", mergeWorkerStatistics(workers_), counters,
                       total_execution_duration / workers_.size());
   return counters.find("sequencer.failed_terminations") == counters.end();
 }
diff --git a/source/client/process_impl.h b/source/client/process_impl.h
index d1f0334cf..11d265fb8 100644
--- a/source/client/process_impl.h
+++ b/source/client/process_impl.h
@@ -80,6 +80,8 @@ class ProcessImpl : public Process, public Envoy::Logger::Loggable<Envoy::Logger
    */
   void shutdown() override;
 
+  bool requestExecutionCancellation() override;
+
 private:
   /**
    * @brief Creates a cluster for usage by a remote request source.
@@ -99,7 +101,13 @@ class ProcessImpl : public Process, public Envoy::Logger::Loggable<Envoy::Logger
   void maybeCreateTracingDriver(const envoy::config::trace::v3::Tracing& configuration);
 
   void configureComponentLogLevels(spdlog::level::level_enum level);
-  const std::vector<ClientWorkerPtr>& createWorkers(const uint32_t concurrency);
+  /**
+   * Prepare the ProcessImpl instance by creating and configuring the workers it needs for execution
+   * of the load test.
+   *
+   * @param concurrency the amount of workers that should be created.
+   */
+  void createWorkers(const uint32_t concurrency);
   std::vector<StatisticPtr> vectorizeStatisticPtrMap(const StatisticPtrMap& statistics) const;
   std::vector<StatisticPtr>
   mergeWorkerStatistics(const std::vector<ClientWorkerPtr>& workers) const;
@@ -145,6 +153,8 @@ class ProcessImpl : public Process, public Envoy::Logger::Loggable<Envoy::Logger
   Envoy::Server::ValidationAdmin admin_;
   Envoy::ProtobufMessage::ProdValidationContextImpl validation_context_;
   bool shutdown_{true};
+  Envoy::Thread::MutexBasicLockable workers_lock_;
+  bool cancelled_{false};
 };
 
 } // namespace Client
diff --git a/source/client/remote_process_impl.cc b/source/client/remote_process_impl.cc
index 1ee4e62b2..05e0b859f 100644
--- a/source/client/remote_process_impl.cc
+++ b/source/client/remote_process_impl.cc
@@ -54,5 +54,11 @@ bool RemoteProcessImpl::run(OutputCollector& collector) {
   return false;
 }
 
+bool RemoteProcessImpl::requestExecutionCancellation() {
+  ENVOY_LOG(error, "Remote process cancellation not supported yet");
+  // TODO(#380): Send a cancel request to the gRPC service.
+  return false;
+}
+
 } // namespace Client
 } // namespace Nighthawk
diff --git a/source/client/remote_process_impl.h b/source/client/remote_process_impl.h
index 775561568..243121cfc 100644
--- a/source/client/remote_process_impl.h
+++ b/source/client/remote_process_impl.h
@@ -34,6 +34,8 @@ class RemoteProcessImpl : public Process, public Envoy::Logger::Loggable<Envoy::
    */
   void shutdown() override{};
 
+  bool requestExecutionCancellation() override;
+
 private:
   const Options& options_;
   nighthawk::client::NighthawkService::Stub& stub_;
diff --git a/source/common/termination_predicate_impl.cc b/source/common/termination_predicate_impl.cc
index 2ad96c5a6..d32f2006b 100644
--- a/source/common/termination_predicate_impl.cc
+++ b/source/common/termination_predicate_impl.cc
@@ -15,10 +15,6 @@ TerminationPredicate::Status TerminationPredicateBaseImpl::evaluateChain() {
   return status;
 }
 
-TerminationPredicate::Status NullTerminationPredicateImpl::evaluate() {
-  return TerminationPredicate::Status::PROCEED;
-}
-
 TerminationPredicate::Status DurationTerminationPredicateImpl::evaluate() {
   return time_source_.monotonicTime() - start_ > duration_ ? TerminationPredicate::Status::TERMINATE
                                                            : TerminationPredicate::Status::PROCEED;
diff --git a/source/common/termination_predicate_impl.h b/source/common/termination_predicate_impl.h
index 80e4c67a9..c1c761345 100644
--- a/source/common/termination_predicate_impl.h
+++ b/source/common/termination_predicate_impl.h
@@ -27,14 +27,6 @@ class TerminationPredicateBaseImpl : public TerminationPredicate {
   TerminationPredicatePtr linked_child_;
 };
 
-/**
- * Predicate which always returns TerminationPredicate::Status::PROCEED.
- */
-class NullTerminationPredicateImpl : public TerminationPredicateBaseImpl {
-public:
-  TerminationPredicate::Status evaluate() override;
-};
-
 /**
  * Predicate which indicates termination iff the passed in duration has expired.
  * time tracking starts at the first call to evaluate().
diff --git a/test/integration/test_integration_basics.py b/test/integration/test_integration_basics.py
index df02ef193..d82fdb478 100644
--- a/test/integration/test_integration_basics.py
+++ b/test/integration/test_integration_basics.py
@@ -1,9 +1,13 @@
 #!/usr/bin/env python3
 
+import json
 import logging
 import os
+import subprocess
 import sys
 import pytest
+import time
+from threading import Thread
 
 from test.integration.common import IpVersion
 from test.integration.integration_test_fixtures import (
@@ -654,6 +658,35 @@ def test_http_request_release_timing(http_test_server_fixture, qps_parameterizat
     assertCounterEqual(counters, "benchmark.http_2xx", (total_requests))
 
 
+def _send_sigterm(process):
+  # Sleep for a while, under tsan the client needs a lot of time
+  # to start up. 10 seconds has been determined to work through
+  # emperical observation.
+  time.sleep(10)
+  process.terminate()
+
+
+def test_cancellation(http_test_server_fixture):
+  """
+  Make sure that we can use signals to cancel execution.
+  """
+  args = [
+      http_test_server_fixture.nighthawk_client_path, "--concurrency", "2",
+      http_test_server_fixture.getTestServerRootUri(), "--duration", "1000", "--output-format",
+      "json"
+  ]
+  client_process = subprocess.Popen(args, stdout=subprocess.PIPE, stderr=subprocess.PIPE)
+  Thread(target=(lambda: _send_sigterm(client_process))).start()
+  stdout, stderr = client_process.communicate()
+  client_process.wait()
+  output = stdout.decode('utf-8')
+  assertEqual(client_process.returncode, 0)
+  parsed_json = json.loads(output)
+  counters = http_test_server_fixture.getNighthawkCounterMapFromJson(parsed_json)
+  assertCounterEqual(counters, "graceful_stop_requested", 2)
+  assertCounterGreaterEqual(counters, "benchmark.http_2xx", 1)
+
+
 def _run_client_with_args(args):
   return run_binary_with_args("nighthawk_client", args)
 
diff --git a/test/process_test.cc b/test/process_test.cc
index 5072bf245..b2b977175 100644
--- a/test/process_test.cc
+++ b/test/process_test.cc
@@ -1,3 +1,4 @@
+#include <thread>
 #include <vector>
 
 #include "nighthawk/common/exception.h"
@@ -32,12 +33,48 @@ class ProcessTest : public TestWithParam<Envoy::Network::Address::IpVersion> {
       : loopback_address_(Envoy::Network::Test::getLoopbackAddressUrlString(GetParam())),
         options_(TestUtility::createOptionsImpl(
             fmt::format("foo --duration 1 -v error --rps 10 https://{}/", loopback_address_))){};
-  void runProcess(RunExpectation expectation) {
+
+  void runProcess(RunExpectation expectation, bool do_cancel = false,
+                  bool terminate_right_away = false) {
     ProcessPtr process = std::make_unique<ProcessImpl>(*options_, time_system_);
     OutputCollectorImpl collector(time_system_, *options_);
+    std::thread cancel_thread;
+    if (do_cancel) {
+      cancel_thread = std::thread([&process, terminate_right_away] {
+        if (!terminate_right_away) {
+          // We sleep to give the the load test execution in the other thread a change to get
+          // started before we request cancellation. Five seconds has been determined to work with
+          // the sanitizer runs in CI through emperical observation.
+          sleep(5);
+        }
+        process->requestExecutionCancellation();
+      });
+      if (terminate_right_away) {
+        cancel_thread.join();
+      }
+    }
     const auto result =
         process->run(collector) ? RunExpectation::EXPECT_SUCCESS : RunExpectation::EXPECT_FAILURE;
     EXPECT_EQ(result, expectation);
+    if (do_cancel) {
+      if (cancel_thread.joinable()) {
+        cancel_thread.join();
+      }
+      auto proto = collector.toProto();
+      if (terminate_right_away) {
+        EXPECT_EQ(0, proto.results().size());
+      } else {
+        int graceful_stop_requested = 0;
+        for (const auto& result : proto.results()) {
+          for (const auto& counter : result.counters()) {
+            if (counter.name() == "graceful_stop_requested") {
+              graceful_stop_requested++;
+            }
+          }
+        }
+        EXPECT_EQ(3, graceful_stop_requested); // global results + two workers
+      }
+    }
     process->shutdown();
   }
 
@@ -64,5 +101,22 @@ TEST_P(ProcessTest, BadTracerSpec) {
   runProcess(RunExpectation::EXPECT_FAILURE);
 }
 
+TEST_P(ProcessTest, CancelDuringLoadTest) {
+  // The failure predicate below is there to wipe out any stock ones. We want this to run for a long
+  // time, even if the upstream fails (there is no live upstream in this test, we send traffic into
+  // the void), so we can check cancellation works.
+  options_ = TestUtility::createOptionsImpl(
+      fmt::format("foo --duration 300 --failure-predicate foo:0 --concurrency 2 https://{}/",
+                  loopback_address_));
+  runProcess(RunExpectation::EXPECT_SUCCESS, true);
+}
+
+TEST_P(ProcessTest, CancelExecutionBeforeBeginLoadTest) {
+  options_ = TestUtility::createOptionsImpl(
+      fmt::format("foo --duration 300 --failure-predicate foo:0 --concurrency 2 https://{}/",
+                  loopback_address_));
+  runProcess(RunExpectation::EXPECT_SUCCESS, true, true);
+}
+
 } // namespace Client
 } // namespace Nighthawk