diff --git a/packages/react-art/src/ReactARTHostConfig.js b/packages/react-art/src/ReactARTHostConfig.js
index 034b2d7290a..d43bcd1a723 100644
--- a/packages/react-art/src/ReactARTHostConfig.js
+++ b/packages/react-art/src/ReactARTHostConfig.js
@@ -363,6 +363,8 @@ export function appendChildToContainer(parentInstance, child) {
   child.inject(parentInstance);
 }
 
+export const appendChildToPortalContainer = appendChildToContainer;
+
 export function insertBefore(parentInstance, child, beforeChild) {
   invariant(
     child !== beforeChild,
diff --git a/packages/react-dom/src/__tests__/ReactDOMComponent-test.js b/packages/react-dom/src/__tests__/ReactDOMComponent-test.js
index e695a845ff5..0fdb06641a5 100644
--- a/packages/react-dom/src/__tests__/ReactDOMComponent-test.js
+++ b/packages/react-dom/src/__tests__/ReactDOMComponent-test.js
@@ -2677,6 +2677,23 @@ describe('ReactDOMComponent', () => {
       const container = document.createElement('div');
       const portalContainer = document.createElement('div');
 
+      function Component() {
+        return ReactDOM.createPortal(
+          <div onClick={() => {}} />,
+          portalContainer,
+        );
+      }
+      const root = ReactDOM.unstable_createRoot(container);
+      root.render(<Component />);
+      jest.runAllTimers();
+
+      expect(typeof portalContainer.onclick).toBe('function');
+    });
+
+    it('adds onclick handler to a portal root mounted via a legacy React root', () => {
+      const container = document.createElement('div');
+      const portalContainer = document.createElement('div');
+
       function Component() {
         return ReactDOM.createPortal(
           <div onClick={() => {}} />,
@@ -2688,7 +2705,21 @@ describe('ReactDOMComponent', () => {
       expect(typeof portalContainer.onclick).toBe('function');
     });
 
-    it('does not add onclick handler to the React root', () => {
+    it('does not add onclick handler to a React root', () => {
+      const container = document.createElement('div');
+
+      function Component() {
+        return <div onClick={() => {}} />;
+      }
+
+      const root = ReactDOM.unstable_createRoot(container);
+      root.render(<Component />);
+      jest.runAllTimers();
+
+      expect(typeof container.onclick).not.toBe('function');
+    });
+
+    it('does not add onclick handler to a legacy React root', () => {
       const container = document.createElement('div');
 
       function Component() {
diff --git a/packages/react-dom/src/client/ReactDOMHostConfig.js b/packages/react-dom/src/client/ReactDOMHostConfig.js
index 86b88ce2bfa..fd8114acaa6 100644
--- a/packages/react-dom/src/client/ReactDOMHostConfig.js
+++ b/packages/react-dom/src/client/ReactDOMHostConfig.js
@@ -370,19 +370,29 @@ export function appendChildToContainer(
     parentNode = container;
     parentNode.appendChild(child);
   }
-  // This container might be used for a portal.
+}
+
+export function appendChildToPortalContainer(
+  container: DOMContainer,
+  child: Instance | TextInstance,
+): void {
+  let parentNode;
+  if (container.nodeType === COMMENT_NODE) {
+    parentNode = (container.parentNode: any);
+    parentNode.insertBefore(child, container);
+  } else {
+    parentNode = container;
+    parentNode.appendChild(child);
+  }
+
   // If something inside a portal is clicked, that click should bubble
   // through the React tree. However, on Mobile Safari the click would
   // never bubble through the *DOM* tree unless an ancestor with onclick
   // event exists. So we wouldn't see it and dispatch it.
-  // This is why we ensure that non React root containers have inline onclick
+  // This is why we ensure that portal containers have inline onclick
   // defined.
   // https://github.com/facebook/react/issues/11918
-  const reactRootContainer = container._reactRootContainer;
-  if (
-    (reactRootContainer === null || reactRootContainer === undefined) &&
-    parentNode.onclick === null
-  ) {
+  if (parentNode.onclick === null) {
     // TODO: This cast may not be sound for SVG, MathML or custom elements.
     trapClickOnNonInteractiveElement(((parentNode: any): HTMLElement));
   }
diff --git a/packages/react-native-renderer/src/ReactNativeHostConfig.js b/packages/react-native-renderer/src/ReactNativeHostConfig.js
index 785e98c1493..4bffd4a3e21 100644
--- a/packages/react-native-renderer/src/ReactNativeHostConfig.js
+++ b/packages/react-native-renderer/src/ReactNativeHostConfig.js
@@ -309,6 +309,8 @@ export function appendChildToContainer(
   );
 }
 
+export const appendChildToPortalContainer = appendChildToContainer;
+
 export function commitTextUpdate(
   textInstance: TextInstance,
   oldText: string,
diff --git a/packages/react-noop-renderer/src/createReactNoop.js b/packages/react-noop-renderer/src/createReactNoop.js
index 42726f41303..e1dfd1ca966 100644
--- a/packages/react-noop-renderer/src/createReactNoop.js
+++ b/packages/react-noop-renderer/src/createReactNoop.js
@@ -391,6 +391,7 @@ function createReactNoop(reconciler: Function, useMutation: boolean) {
 
         appendChild,
         appendChildToContainer,
+        appendChildToPortalContainer: appendChildToContainer,
         insertBefore,
         insertInContainerBefore,
         removeChild,
diff --git a/packages/react-reconciler/src/ReactFiberCommitWork.js b/packages/react-reconciler/src/ReactFiberCommitWork.js
index 76e136dd7db..8d973bad049 100644
--- a/packages/react-reconciler/src/ReactFiberCommitWork.js
+++ b/packages/react-reconciler/src/ReactFiberCommitWork.js
@@ -75,6 +75,7 @@ import {
   commitTextUpdate,
   appendChild,
   appendChildToContainer,
+  appendChildToPortalContainer,
   insertBefore,
   insertInContainerBefore,
   removeChild,
@@ -951,7 +952,11 @@ function commitPlacement(finishedWork: Fiber): void {
         }
       } else {
         if (isContainer) {
-          appendChildToContainer(parent, node.stateNode);
+          if (parentFiber.tag === HostRoot) {
+            appendChildToContainer(parent, node.stateNode);
+          } else {
+            appendChildToPortalContainer(parent, node.stateNode);
+          }
         } else {
           appendChild(parent, node.stateNode);
         }
diff --git a/packages/react-reconciler/src/__tests__/ReactFiberHostContext-test.js b/packages/react-reconciler/src/__tests__/ReactFiberHostContext-test.js
index 4dbc13bd814..de825a29d38 100644
--- a/packages/react-reconciler/src/__tests__/ReactFiberHostContext-test.js
+++ b/packages/react-reconciler/src/__tests__/ReactFiberHostContext-test.js
@@ -49,6 +49,9 @@ describe('ReactFiberHostContext', () => {
       appendChildToContainer: function() {
         return null;
       },
+      appendChildToPortalContainer: function() {
+        return null;
+      },
       supportsMutation: true,
     });
 
@@ -97,6 +100,9 @@ describe('ReactFiberHostContext', () => {
       appendChildToContainer: function() {
         return null;
       },
+      appendChildToPortalContainer: function() {
+        return null;
+      },
       supportsMutation: true,
     });
 
diff --git a/packages/react-reconciler/src/forks/ReactFiberHostConfig.custom.js b/packages/react-reconciler/src/forks/ReactFiberHostConfig.custom.js
index b217c22f1c6..212a054a8d7 100644
--- a/packages/react-reconciler/src/forks/ReactFiberHostConfig.custom.js
+++ b/packages/react-reconciler/src/forks/ReactFiberHostConfig.custom.js
@@ -68,6 +68,8 @@ export const supportsHydration = $$$hostConfig.supportsHydration;
 // -------------------
 export const appendChild = $$$hostConfig.appendChild;
 export const appendChildToContainer = $$$hostConfig.appendChildToContainer;
+export const appendChildToPortalContainer =
+  $$$hostConfig.appendChildToPortalContainer;
 export const commitTextUpdate = $$$hostConfig.commitTextUpdate;
 export const commitMount = $$$hostConfig.commitMount;
 export const commitUpdate = $$$hostConfig.commitUpdate;
diff --git a/packages/react-test-renderer/src/ReactTestHostConfig.js b/packages/react-test-renderer/src/ReactTestHostConfig.js
index b4e6f681fac..58ab914f7b2 100644
--- a/packages/react-test-renderer/src/ReactTestHostConfig.js
+++ b/packages/react-test-renderer/src/ReactTestHostConfig.js
@@ -251,6 +251,7 @@ export function resetTextContent(testElement: Instance): void {
 }
 
 export const appendChildToContainer = appendChild;
+export const appendChildToPortalContainer = appendChild;
 export const insertInContainerBefore = insertBefore;
 export const removeChildFromContainer = removeChild;
 
diff --git a/packages/shared/HostConfigWithNoMutation.js b/packages/shared/HostConfigWithNoMutation.js
index badb80920b1..87b86911b2c 100644
--- a/packages/shared/HostConfigWithNoMutation.js
+++ b/packages/shared/HostConfigWithNoMutation.js
@@ -25,6 +25,7 @@ function shim(...args: any) {
 export const supportsMutation = false;
 export const appendChild = shim;
 export const appendChildToContainer = shim;
+export const appendChildToPortalContainer = shim;
 export const commitTextUpdate = shim;
 export const commitMount = shim;
 export const commitUpdate = shim;