diff --git a/packages/react-dom/src/__tests__/ReactDOMServerPartialHydration-test.internal.js b/packages/react-dom/src/__tests__/ReactDOMServerPartialHydration-test.internal.js
index 8f67689f835..5b466f2431d 100644
--- a/packages/react-dom/src/__tests__/ReactDOMServerPartialHydration-test.internal.js
+++ b/packages/react-dom/src/__tests__/ReactDOMServerPartialHydration-test.internal.js
@@ -1003,4 +1003,58 @@ describe('ReactDOMServerPartialHydration', () => {
     let div = container.getElementsByTagName('div')[0];
     expect(ref.current).toBe(div);
   });
+
+  it('can client render nested boundaries', async () => {
+    let suspend = false;
+    let promise = new Promise(() => {});
+    let ref = React.createRef();
+
+    function Child() {
+      if (suspend) {
+        throw promise;
+      } else {
+        return 'Hello';
+      }
+    }
+
+    function App() {
+      return (
+        <div>
+          <Suspense
+            fallback={
+              <React.Fragment>
+                <Suspense fallback="Loading...">
+                  <Child />
+                </Suspense>
+                <span>Inner Sibling</span>
+              </React.Fragment>
+            }>
+            <Child />
+          </Suspense>
+          <span ref={ref}>Sibling</span>
+        </div>
+      );
+    }
+
+    suspend = true;
+    let html = ReactDOMServer.renderToString(<App />);
+
+    let container = document.createElement('div');
+    container.innerHTML = html + '<!--unrelated comment-->';
+
+    let span = container.getElementsByTagName('span')[1];
+
+    suspend = false;
+    let root = ReactDOM.unstable_createRoot(container, {hydrate: true});
+    root.render(<App />);
+    Scheduler.unstable_flushAll();
+    jest.runAllTimers();
+
+    expect(ref.current).toBe(span);
+    expect(span.parentNode).not.toBe(null);
+
+    // It leaves non-React comments alone.
+    expect(container.lastChild.nodeType).toBe(8);
+    expect(container.lastChild.data).toBe('unrelated comment');
+  });
 });
diff --git a/packages/react-dom/src/client/ReactDOMHostConfig.js b/packages/react-dom/src/client/ReactDOMHostConfig.js
index 48425c1c8d9..bc2e94f802d 100644
--- a/packages/react-dom/src/client/ReactDOMHostConfig.js
+++ b/packages/react-dom/src/client/ReactDOMHostConfig.js
@@ -610,15 +610,14 @@ function getNextHydratable(node) {
     }
     if (enableSuspenseServerRenderer) {
       if (nodeType === COMMENT_NODE) {
-        break;
-      }
-      const nodeData = (node: any).data;
-      if (
-        nodeData === SUSPENSE_START_DATA ||
-        nodeData === SUSPENSE_FALLBACK_START_DATA ||
-        nodeData === SUSPENSE_PENDING_START_DATA
-      ) {
-        break;
+        const nodeData = (node: any).data;
+        if (
+          nodeData === SUSPENSE_START_DATA ||
+          nodeData === SUSPENSE_FALLBACK_START_DATA ||
+          nodeData === SUSPENSE_PENDING_START_DATA
+        ) {
+          break;
+        }
       }
     }
   }
@@ -691,7 +690,11 @@ export function getNextHydratableInstanceAfterSuspenseInstance(
         } else {
           depth--;
         }
-      } else if (data === SUSPENSE_START_DATA) {
+      } else if (
+        data === SUSPENSE_START_DATA ||
+        data === SUSPENSE_FALLBACK_START_DATA ||
+        data === SUSPENSE_PENDING_START_DATA
+      ) {
         depth++;
       }
     }