diff --git a/CHANGES b/CHANGES
index 6e1bcf1c..cd8cc233 100644
--- a/CHANGES
+++ b/CHANGES
@@ -5,6 +5,7 @@
   since they are not actual properties of the class instance.
   Use `responses.mock.assert_all_requests_are_fired`,
   `responses.mock.passthru_prefixes`, `responses.mock.target` instead.
+* Fixed the issue when `reset()` method was called in not stopped mock. See #511
 
 0.19.0
 ------
diff --git a/responses/__init__.py b/responses/__init__.py
index 91ee3ea4..d8d5438a 100644
--- a/responses/__init__.py
+++ b/responses/__init__.py
@@ -560,7 +560,6 @@ def reset(self):
         self._registry = FirstMatchRegistry()
         self._calls.reset()
         self.passthru_prefixes = ()
-        self._patcher = None
 
     def add(
         self,
@@ -834,6 +833,8 @@ def _on_request(self, adapter, request, **kwargs):
     def start(self):
         if self._patcher:
             # we must not override value of the _patcher if already applied
+            # this prevents issues when one decorated function is called from
+            # another decorated function
             return
 
         def unbound_on_send(adapter, request, *a, **kwargs):
@@ -847,6 +848,10 @@ def stop(self, allow_assert=True):
             # prevent stopping unstarted patchers
             self._patcher.stop()
 
+            # once patcher is stopped, clean it. This is required to create a new
+            # fresh patcher on self.start()
+            self._patcher = None
+
         if not self.assert_all_requests_are_fired:
             return
 
diff --git a/responses/tests/test_responses.py b/responses/tests/test_responses.py
index 9f2212c2..05e816e2 100644
--- a/responses/tests/test_responses.py
+++ b/responses/tests/test_responses.py
@@ -2127,3 +2127,16 @@ def run():
 
         run()
         assert_reset()
+
+
+def test_reset_in_the_middle():
+    @responses.activate
+    def run():
+        with responses.RequestsMock() as rsps2:
+            rsps2.reset()
+        responses.add(responses.GET, "https://example.invalid", status=200)
+        resp = requests.request("GET", "https://example.invalid")
+        assert resp.status_code == 200
+
+    run()
+    assert_reset()