diff --git a/packages/hono/src/cloudflare/middleware.ts b/packages/hono/src/cloudflare/middleware.ts
index c1d6a80335a7..ffcdf5e40346 100644
--- a/packages/hono/src/cloudflare/middleware.ts
+++ b/packages/hono/src/cloudflare/middleware.ts
@@ -9,6 +9,7 @@ import {
 } from '@sentry/core';
 import type { Context, Hono, MiddlewareHandler } from 'hono';
 import { requestHandler, responseHandler } from '../shared/middlewareHandlers';
+import { patchAppUse } from '../shared/patchAppUse';
 
 export interface HonoOptions extends Options<BaseTransportOptions> {
   context?: Context;
@@ -42,6 +43,8 @@ export const sentry = (app: Hono, options: HonoOptions | undefined = {}): Middle
     app,
   );
 
+  patchAppUse(app);
+
   return async (context, next) => {
     requestHandler(context);
 
diff --git a/packages/hono/src/shared/patchAppUse.ts b/packages/hono/src/shared/patchAppUse.ts
new file mode 100644
index 000000000000..dfcd186dc38a
--- /dev/null
+++ b/packages/hono/src/shared/patchAppUse.ts
@@ -0,0 +1,64 @@
+import {
+  captureException,
+  SEMANTIC_ATTRIBUTE_SENTRY_OP,
+  SEMANTIC_ATTRIBUTE_SENTRY_ORIGIN,
+  SPAN_STATUS_ERROR,
+  SPAN_STATUS_OK,
+  startInactiveSpan,
+} from '@sentry/core';
+import type { Hono, MiddlewareHandler } from 'hono';
+
+const MIDDLEWARE_ORIGIN = 'auto.middleware.hono';
+
+/**
+ * Patches `app.use` so that every middleware registered through it is automatically
+ * wrapped in a Sentry span. Supports both forms: `app.use(...handlers)` and `app.use(path, ...handlers)`.
+ */
+export function patchAppUse(app: Hono): void {
+  app.use = new Proxy(app.use, {
+    apply(target: typeof app.use, thisArg: typeof app, args: Parameters<typeof app.use>): ReturnType<typeof app.use> {
+      const [first, ...rest] = args as [unknown, ...MiddlewareHandler[]];
+
+      if (typeof first === 'string') {
+        const wrappedHandlers = rest.map(handler => wrapMiddlewareWithSpan(handler));
+        return Reflect.apply(target, thisArg, [first, ...wrappedHandlers]);
+      }
+
+      const allHandlers = [first as MiddlewareHandler, ...rest].map(handler => wrapMiddlewareWithSpan(handler));
+      return Reflect.apply(target, thisArg, allHandlers);
+    },
+  });
+}
+
+/**
+ * Wraps a Hono middleware handler so that its execution is traced as a Sentry span.
+ * Uses startInactiveSpan so that all middleware spans are siblings under the request/transaction
+ * (onion order: A → B → handler → B → A does not nest B under A in the trace).
+ */
+function wrapMiddlewareWithSpan(handler: MiddlewareHandler): MiddlewareHandler {
+  return async function sentryTracedMiddleware(context, next) {
+    const span = startInactiveSpan({
+      name: handler.name || '<anonymous>',
+      op: 'middleware.hono',
+      onlyIfParent: true,
+      attributes: {
+        [SEMANTIC_ATTRIBUTE_SENTRY_OP]: 'middleware.hono',
+        [SEMANTIC_ATTRIBUTE_SENTRY_ORIGIN]: MIDDLEWARE_ORIGIN,
+      },
+    });
+
+    try {
+      const result = await handler(context, next);
+      span.setStatus({ code: SPAN_STATUS_OK });
+      return result;
+    } catch (error) {
+      span.setStatus({ code: SPAN_STATUS_ERROR, message: 'internal_error' });
+      captureException(error, {
+        mechanism: { handled: false, type: MIDDLEWARE_ORIGIN },
+      });
+      throw error;
+    } finally {
+      span.end();
+    }
+  };
+}
diff --git a/packages/hono/test/shared/patchAppUse.test.ts b/packages/hono/test/shared/patchAppUse.test.ts
new file mode 100644
index 000000000000..8f4e3bc0cc6c
--- /dev/null
+++ b/packages/hono/test/shared/patchAppUse.test.ts
@@ -0,0 +1,158 @@
+import * as SentryCore from '@sentry/core';
+import { Hono } from 'hono';
+import { beforeEach, describe, expect, it, vi } from 'vitest';
+import { patchAppUse } from '../../src/shared/patchAppUse';
+
+vi.mock('@sentry/core', async () => {
+  const actual = await vi.importActual('@sentry/core');
+  return {
+    ...actual,
+    startInactiveSpan: vi.fn((_opts: unknown) => ({
+      setStatus: vi.fn(),
+      end: vi.fn(),
+    })),
+    captureException: vi.fn(),
+  };
+});
+
+const startInactiveSpanMock = SentryCore.startInactiveSpan as ReturnType<typeof vi.fn>;
+const captureExceptionMock = SentryCore.captureException as ReturnType<typeof vi.fn>;
+
+describe('patchAppUse (middleware spans)', () => {
+  beforeEach(() => {
+    vi.clearAllMocks();
+  });
+
+  it('wraps handlers in app.use(handler) so startInactiveSpan is called when middleware runs', async () => {
+    const app = new Hono();
+    patchAppUse(app);
+
+    const userHandler = vi.fn(async (_c: unknown, next: () => Promise<void>) => {
+      await next();
+    });
+    app.use(userHandler);
+
+    expect(startInactiveSpanMock).not.toHaveBeenCalled();
+
+    const fetchHandler = app.fetch;
+    const req = new Request('http://localhost/');
+    await fetchHandler(req);
+
+    expect(startInactiveSpanMock).toHaveBeenCalledTimes(1);
+    expect(startInactiveSpanMock).toHaveBeenCalledWith(
+      expect.objectContaining({
+        op: 'middleware.hono',
+        onlyIfParent: true,
+        attributes: expect.objectContaining({
+          'sentry.op': 'middleware.hono',
+          'sentry.origin': 'auto.middleware.hono',
+        }),
+      }),
+    );
+    expect(userHandler).toHaveBeenCalled();
+  });
+
+  describe('span naming', () => {
+    it('uses handler.name for span when handler has a name', async () => {
+      const app = new Hono();
+      patchAppUse(app);
+
+      async function myNamedMiddleware(_c: unknown, next: () => Promise<void>) {
+        await next();
+      }
+      app.use(myNamedMiddleware);
+
+      await app.fetch(new Request('http://localhost/'));
+
+      expect(startInactiveSpanMock).toHaveBeenCalledWith(expect.objectContaining({ name: 'myNamedMiddleware' }));
+    });
+
+    it('uses <anonymous.index> for span when handler is anonymous', async () => {
+      const app = new Hono();
+      patchAppUse(app);
+
+      app.use(async (_c: unknown, next: () => Promise<void>) => next());
+
+      await app.fetch(new Request('http://localhost/'));
+
+      expect(startInactiveSpanMock).toHaveBeenCalledTimes(1);
+      const name = startInactiveSpanMock.mock.calls[0][0].name;
+      expect(name).toMatch('<anonymous>');
+    });
+  });
+
+  it('wraps each handler in app.use(path, ...handlers) and passes path through', async () => {
+    const app = new Hono();
+    patchAppUse(app);
+
+    const handler = async (_c: unknown, next: () => Promise<void>) => next();
+    app.use('/api', handler);
+    app.get('/api', () => new Response('ok'));
+
+    await app.fetch(new Request('http://localhost/api'));
+
+    expect(startInactiveSpanMock).toHaveBeenCalled();
+  });
+
+  it('calls captureException when middleware throws', async () => {
+    const app = new Hono();
+    patchAppUse(app);
+
+    const err = new Error('middleware error');
+    app.use(async () => {
+      throw err;
+    });
+
+    const res = await app.fetch(new Request('http://localhost/'));
+    expect(res.status).toBe(500);
+
+    expect(captureExceptionMock).toHaveBeenCalledWith(err, {
+      mechanism: { handled: false, type: 'auto.middleware.hono' },
+    });
+  });
+
+  it('creates sibling spans for multiple middlewares (onion order, not parent-child)', async () => {
+    const app = new Hono();
+    patchAppUse(app);
+
+    app.use(
+      async (_c: unknown, next: () => Promise<void>) => next(),
+      async function namedMiddleware(_c: unknown, next: () => Promise<void>) {
+        await next();
+      },
+      async (_c: unknown, next: () => Promise<void>) => next(),
+    );
+
+    await app.fetch(new Request('http://localhost/'));
+
+    expect(startInactiveSpanMock).toHaveBeenCalledTimes(3);
+    const [firstCall, secondCall, thirdCall] = startInactiveSpanMock.mock.calls;
+    expect(firstCall[0]).toMatchObject({ op: 'middleware.hono' });
+    expect(secondCall[0]).toMatchObject({ op: 'middleware.hono' });
+    expect(firstCall[0].name).toMatch('<anonymous>');
+    expect(secondCall[0].name).toBe('namedMiddleware');
+    expect(thirdCall[0].name).toBe('<anonymous>');
+    expect(firstCall[0].name).not.toBe(secondCall[0].name);
+  });
+
+  it('preserves this context when calling the original use (Proxy forwards thisArg)', () => {
+    type FakeApp = {
+      _capturedThis: unknown;
+      use: (...args: unknown[]) => FakeApp;
+    };
+    const fakeApp: FakeApp = {
+      _capturedThis: null,
+      use(this: FakeApp, ..._args: unknown[]) {
+        this._capturedThis = this;
+        return this;
+      },
+    };
+
+    patchAppUse(fakeApp as unknown as Parameters<typeof patchAppUse>[0]);
+
+    const noop = async (_c: unknown, next: () => Promise<void>) => next();
+    fakeApp.use(noop);
+
+    expect(fakeApp._capturedThis).toBe(fakeApp);
+  });
+});