diff --git a/github/github-accessors.go b/github/github-accessors.go
index bd94ba944c2..780f03ca084 100644
--- a/github/github-accessors.go
+++ b/github/github-accessors.go
@@ -1188,6 +1188,46 @@ func (a *AuthorizationUpdateRequest) GetNoteURL() string {
 	return *a.NoteURL
 }
 
+// GetID returns the ID field if it's non-nil, zero value otherwise.
+func (a *Autolink) GetID() int64 {
+	if a == nil || a.ID == nil {
+		return 0
+	}
+	return *a.ID
+}
+
+// GetKeyPrefix returns the KeyPrefix field if it's non-nil, zero value otherwise.
+func (a *Autolink) GetKeyPrefix() string {
+	if a == nil || a.KeyPrefix == nil {
+		return ""
+	}
+	return *a.KeyPrefix
+}
+
+// GetURLTemplate returns the URLTemplate field if it's non-nil, zero value otherwise.
+func (a *Autolink) GetURLTemplate() string {
+	if a == nil || a.URLTemplate == nil {
+		return ""
+	}
+	return *a.URLTemplate
+}
+
+// GetKeyPrefix returns the KeyPrefix field if it's non-nil, zero value otherwise.
+func (a *AutolinkOptions) GetKeyPrefix() string {
+	if a == nil || a.KeyPrefix == nil {
+		return ""
+	}
+	return *a.KeyPrefix
+}
+
+// GetURLTemplate returns the URLTemplate field if it's non-nil, zero value otherwise.
+func (a *AutolinkOptions) GetURLTemplate() string {
+	if a == nil || a.URLTemplate == nil {
+		return ""
+	}
+	return *a.URLTemplate
+}
+
 // GetAppID returns the AppID field if it's non-nil, zero value otherwise.
 func (a *AutoTriggerCheck) GetAppID() int64 {
 	if a == nil || a.AppID == nil {
diff --git a/github/github-accessors_test.go b/github/github-accessors_test.go
index 4264ce8b9ad..29b41b889a1 100644
--- a/github/github-accessors_test.go
+++ b/github/github-accessors_test.go
@@ -1417,6 +1417,56 @@ func TestAuthorizationUpdateRequest_GetNoteURL(tt *testing.T) {
 	a.GetNoteURL()
 }
 
+func TestAutolink_GetID(tt *testing.T) {
+	var zeroValue int64
+	a := &Autolink{ID: &zeroValue}
+	a.GetID()
+	a = &Autolink{}
+	a.GetID()
+	a = nil
+	a.GetID()
+}
+
+func TestAutolink_GetKeyPrefix(tt *testing.T) {
+	var zeroValue string
+	a := &Autolink{KeyPrefix: &zeroValue}
+	a.GetKeyPrefix()
+	a = &Autolink{}
+	a.GetKeyPrefix()
+	a = nil
+	a.GetKeyPrefix()
+}
+
+func TestAutolink_GetURLTemplate(tt *testing.T) {
+	var zeroValue string
+	a := &Autolink{URLTemplate: &zeroValue}
+	a.GetURLTemplate()
+	a = &Autolink{}
+	a.GetURLTemplate()
+	a = nil
+	a.GetURLTemplate()
+}
+
+func TestAutolinkOptions_GetKeyPrefix(tt *testing.T) {
+	var zeroValue string
+	a := &AutolinkOptions{KeyPrefix: &zeroValue}
+	a.GetKeyPrefix()
+	a = &AutolinkOptions{}
+	a.GetKeyPrefix()
+	a = nil
+	a.GetKeyPrefix()
+}
+
+func TestAutolinkOptions_GetURLTemplate(tt *testing.T) {
+	var zeroValue string
+	a := &AutolinkOptions{URLTemplate: &zeroValue}
+	a.GetURLTemplate()
+	a = &AutolinkOptions{}
+	a.GetURLTemplate()
+	a = nil
+	a.GetURLTemplate()
+}
+
 func TestAutoTriggerCheck_GetAppID(tt *testing.T) {
 	var zeroValue int64
 	a := &AutoTriggerCheck{AppID: &zeroValue}
diff --git a/github/repos_autolinks.go b/github/repos_autolinks.go
new file mode 100644
index 00000000000..b6404783eb7
--- /dev/null
+++ b/github/repos_autolinks.go
@@ -0,0 +1,102 @@
+// Copyright 2021 The go-github AUTHORS. All rights reserved.
+//
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package github
+
+import (
+	"context"
+	"fmt"
+)
+
+// AutolinkOptions specifies parameters for RepositoriesService.AddAutolink method.
+type AutolinkOptions struct {
+	KeyPrefix   *string `json:"key_prefix,omitempty"`
+	URLTemplate *string `json:"url_template,omitempty"`
+}
+
+// Autolink represents autolinks to external resources like JIRA issues and Zendesk tickets.
+type Autolink struct {
+	ID          *int64  `json:"id,omitempty"`
+	KeyPrefix   *string `json:"key_prefix,omitempty"`
+	URLTemplate *string `json:"url_template,omitempty"`
+}
+
+// ListAutolinks returns a list of autolinks configured for the given repository.
+// Information about autolinks are only available to repository administrators.
+//
+// GitHub API docs: https://docs.github.com/en/rest/reference/repos#list-all-autolinks-of-a-repository
+func (s *RepositoriesService) ListAutolinks(ctx context.Context, owner, repo string, opts *ListOptions) ([]*Autolink, *Response, error) {
+	u := fmt.Sprintf("repos/%v/%v/autolinks", owner, repo)
+	u, err := addOptions(u, opts)
+	if err != nil {
+		return nil, nil, err
+	}
+
+	req, err := s.client.NewRequest("GET", u, nil)
+	if err != nil {
+		return nil, nil, err
+	}
+
+	var autolinks []*Autolink
+	resp, err := s.client.Do(ctx, req, &autolinks)
+	if err != nil {
+		return nil, resp, err
+	}
+
+	return autolinks, resp, nil
+}
+
+// AddAutolink creates an autolink reference for a repository.
+// Users with admin access to the repository can create an autolink.
+//
+// GitHub API docs: https://docs.github.com/en/rest/reference/repos#create-an-autolink-reference-for-a-repository
+func (s *RepositoriesService) AddAutolink(ctx context.Context, owner, repo string, opts *AutolinkOptions) (*Autolink, *Response, error) {
+	u := fmt.Sprintf("repos/%v/%v/autolinks", owner, repo)
+	req, err := s.client.NewRequest("POST", u, opts)
+	if err != nil {
+		return nil, nil, err
+	}
+
+	al := new(Autolink)
+	resp, err := s.client.Do(ctx, req, al)
+	if err != nil {
+		return nil, resp, err
+	}
+	return al, resp, nil
+}
+
+// GetAutolink returns a single autolink reference by ID that was configured for the given repository.
+// Information about autolinks are only available to repository administrators.
+//
+// GitHub API docs: https://docs.github.com/en/rest/reference/repos#get-an-autolink-reference-of-a-repository
+func (s *RepositoriesService) GetAutolink(ctx context.Context, owner, repo string, id int64) (*Autolink, *Response, error) {
+	u := fmt.Sprintf("repos/%v/%v/autolinks/%v", owner, repo, id)
+
+	req, err := s.client.NewRequest("GET", u, nil)
+	if err != nil {
+		return nil, nil, err
+	}
+
+	var autolink *Autolink
+	resp, err := s.client.Do(ctx, req, &autolink)
+	if err != nil {
+		return nil, resp, err
+	}
+
+	return autolink, resp, nil
+}
+
+// DeleteAutolink deletes a single autolink reference by ID that was configured for the given repository.
+// Information about autolinks are only available to repository administrators.
+//
+// GitHub API docs: https://docs.github.com/en/rest/reference/repos#delete-an-autolink-reference-from-a-repository
+func (s *RepositoriesService) DeleteAutolink(ctx context.Context, owner, repo string, id int64) (*Response, error) {
+	u := fmt.Sprintf("repos/%v/%v/autolinks/%v", owner, repo, id)
+	req, err := s.client.NewRequest("DELETE", u, nil)
+	if err != nil {
+		return nil, err
+	}
+	return s.client.Do(ctx, req, nil)
+}
diff --git a/github/repos_autolinks_test.go b/github/repos_autolinks_test.go
new file mode 100644
index 00000000000..b6121d2c7bd
--- /dev/null
+++ b/github/repos_autolinks_test.go
@@ -0,0 +1,154 @@
+// Copyright 2021 The go-github AUTHORS. All rights reserved.
+//
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package github
+
+import (
+	"context"
+	"encoding/json"
+	"fmt"
+	"net/http"
+	"testing"
+
+	"github.com/google/go-cmp/cmp"
+)
+
+func TestRepositoriesService_ListAutolinks(t *testing.T) {
+	client, mux, _, teardown := setup()
+	defer teardown()
+
+	mux.HandleFunc("/repos/o/r/autolinks", func(w http.ResponseWriter, r *http.Request) {
+		testMethod(t, r, "GET")
+		testFormValues(t, r, values{"page": "2"})
+		fmt.Fprintf(w, `[{"id":1, "key_prefix": "TICKET-", "url_template": "https://example.com/TICKET?query=<num>"}, {"id":2, "key_prefix": "STORY-", "url_template": "https://example.com/STORY?query=<num>"}]`)
+	})
+
+	opt := &ListOptions{
+		Page: 2,
+	}
+	ctx := context.Background()
+	autolinks, _, err := client.Repositories.ListAutolinks(ctx, "o", "r", opt)
+	if err != nil {
+		t.Errorf("Repositories.ListAutolinks returned error: %v", err)
+	}
+
+	want := []*Autolink{
+		{ID: Int64(1), KeyPrefix: String("TICKET-"), URLTemplate: String("https://example.com/TICKET?query=<num>")},
+		{ID: Int64(2), KeyPrefix: String("STORY-"), URLTemplate: String("https://example.com/STORY?query=<num>")},
+	}
+
+	if !cmp.Equal(autolinks, want) {
+		t.Errorf("Repositories.ListAutolinks returned %+v, want %+v", autolinks, want)
+	}
+
+	const methodName = "ListAutolinks"
+	testBadOptions(t, methodName, func() (err error) {
+		_, _, err = client.Repositories.ListAutolinks(ctx, "\n", "\n", opt)
+		return err
+	})
+
+	testNewRequestAndDoFailure(t, methodName, client, func() (*Response, error) {
+		got, resp, err := client.Repositories.ListAutolinks(ctx, "o", "r", opt)
+		if got != nil {
+			t.Errorf("testNewRequestAndDoFailure %v = %#v, want nil", methodName, got)
+		}
+		return resp, err
+	})
+}
+
+func TestRepositoriesService_AddAutolink(t *testing.T) {
+	client, mux, _, teardown := setup()
+	defer teardown()
+
+	opt := &AutolinkOptions{KeyPrefix: String("TICKET-"), URLTemplate: String("https://example.com/TICKET?query=<num>")}
+	mux.HandleFunc("/repos/o/r/autolinks", func(w http.ResponseWriter, r *http.Request) {
+		v := new(AutolinkOptions)
+		json.NewDecoder(r.Body).Decode(v)
+		testMethod(t, r, "POST")
+		if !cmp.Equal(v, opt) {
+			t.Errorf("Request body = %+v, want %+v", v, opt)
+		}
+		w.WriteHeader(http.StatusOK)
+		w.Write([]byte(`{"key_prefix": "TICKET-","url_template": "https://example.com/TICKET?query=<num>"}`))
+	})
+	ctx := context.Background()
+	autolink, _, err := client.Repositories.AddAutolink(ctx, "o", "r", opt)
+	if err != nil {
+		t.Errorf("Repositories.AddAutolink returned error: %v", err)
+	}
+	want := &Autolink{
+		KeyPrefix:   String("TICKET-"),
+		URLTemplate: String("https://example.com/TICKET?query=<num>"),
+	}
+
+	if !cmp.Equal(autolink, want) {
+		t.Errorf("AddAutolink returned %+v, want %+v", autolink, want)
+	}
+
+	const methodName = "AddAutolink"
+	testBadOptions(t, methodName, func() (err error) {
+		_, _, err = client.Repositories.AddAutolink(ctx, "\n", "\n", opt)
+		return err
+	})
+
+	testNewRequestAndDoFailure(t, methodName, client, func() (*Response, error) {
+		got, resp, err := client.Repositories.AddAutolink(ctx, "o", "r", opt)
+		if got != nil {
+			t.Errorf("testNewRequestAndDoFailure %v = %#v, want nil", methodName, got)
+		}
+		return resp, err
+	})
+}
+
+func TestRepositoriesService_GetAutolink(t *testing.T) {
+	client, mux, _, teardown := setup()
+	defer teardown()
+
+	mux.HandleFunc("/repos/o/r/autolinks/1", func(w http.ResponseWriter, r *http.Request) {
+		testMethod(t, r, "GET")
+		fmt.Fprintf(w, `{"id":1, "key_prefix": "TICKET-", "url_template": "https://example.com/TICKET?query=<num>"}`)
+	})
+
+	ctx := context.Background()
+	autolink, _, err := client.Repositories.GetAutolink(ctx, "o", "r", 1)
+	if err != nil {
+		t.Errorf("Repositories.GetAutolink returned error: %v", err)
+	}
+
+	want := &Autolink{ID: Int64(1), KeyPrefix: String("TICKET-"), URLTemplate: String("https://example.com/TICKET?query=<num>")}
+	if !cmp.Equal(autolink, want) {
+		t.Errorf("Repositories.GetAutolink returned %+v, want %+v", autolink, want)
+	}
+
+	const methodName = "GetAutolink"
+	testNewRequestAndDoFailure(t, methodName, client, func() (*Response, error) {
+		got, resp, err := client.Repositories.GetAutolink(ctx, "o", "r", 2)
+		if got != nil {
+			t.Errorf("testNewRequestAndDoFailure %v = %#v, want nil", methodName, got)
+		}
+		return resp, err
+	})
+}
+
+func TestRepositoriesService_DeleteAutolink(t *testing.T) {
+	client, mux, _, teardown := setup()
+	defer teardown()
+
+	mux.HandleFunc("/repos/o/r/autolinks/1", func(w http.ResponseWriter, r *http.Request) {
+		testMethod(t, r, "DELETE")
+		w.WriteHeader(http.StatusNoContent)
+	})
+
+	ctx := context.Background()
+	_, err := client.Repositories.DeleteAutolink(ctx, "o", "r", 1)
+	if err != nil {
+		t.Errorf("Repositories.DeleteAutolink returned error: %v", err)
+	}
+
+	const methodName = "DeleteAutolink"
+	testNewRequestAndDoFailure(t, methodName, client, func() (*Response, error) {
+		return client.Repositories.DeleteAutolink(ctx, "o", "r", 2)
+	})
+}