From 40be503c356dbd5507f9107628fbb0754720c9d1 Mon Sep 17 00:00:00 2001 From: hutaobo Date: Wed, 29 Apr 2026 17:24:22 +0200 Subject: [PATCH 1/2] refactor: rename ligand receptor workflow to cci --- .gitignore | 22 +- README.md | 2 +- .../README.md | 68 +- .../configs/benchmark.yaml | 6 +- .../configs/canonical_axes.yaml | 0 .../configs/methods.yaml | 110 ++- .../configs/pathways.yaml | 0 .../data/.gitkeep | 0 .../envs/bootstrap_cellchat_mainline.R | 0 .../envs/bootstrap_env.py | 2 +- .../envs/pyx-cci-cellagentchat.yml} | 2 +- .../envs/pyx-cci-cellnest.yml} | 2 +- .../envs/pyx-cci-cellphonedb.yml} | 2 +- .../envs/pyx-cci-commot.yml} | 2 +- .../envs/pyx-cci-laris.yml} | 2 +- .../envs/pyx-cci-liana.yml} | 2 +- .../envs/pyx-cci-prep.yml} | 2 +- .../envs/pyx-cci-pyxenium.yml} | 2 +- .../envs/pyx-cci-scild.yml} | 2 +- .../envs/pyx-cci-spatialdm.yml} | 2 +- .../envs/pyx-cci-squidpy.yml} | 2 +- .../envs/pyx-cci-stlearn.yml} | 2 +- .../envs/r-cci-cellchat.yml} | 2 +- .../envs/r-cci-giotto.yml} | 2 +- .../envs/r-cci-niches.yml} | 2 +- .../envs/r-cci-spatalk.yml} | 2 +- .../logs/.gitkeep | 0 .../reports/.gitkeep | 0 .../results/.gitkeep | 0 .../runners/python/run_commot.py | 6 +- .../runners/python/run_liana.py | 6 +- .../runners/python/run_method_stub.py | 2 +- .../runners/python/run_pyxenium.py | 12 +- .../runners/python/run_squidpy.py | 6 +- .../runners/r/run_cellchat.R | 8 +- .../runners/r/run_external_cci_method.R} | 30 +- .../runners/r/run_giotto.R | 14 +- .../runners/r/run_method_stub.R | 0 .../runners/r/run_niches.R | 24 +- .../runners/r/run_r_cci_utils.R} | 14 +- .../runners/r/run_spatalk.R | 16 +- .../runs/.gitkeep | 0 .../scripts/aggregate_results.py | 2 +- .../scripts/collect_a100_results.py | 2 +- .../scripts/create_env.py | 2 +- .../scripts/finalize_a100_full_common.py | 18 +- .../scripts/pdc/collect_pdc_results.py | 6 +- .../scripts/pdc/monitor_pdc_jobs.py | 8 +- .../scripts/pdc/prepare_pdc_bundle.sh | 26 +- .../scripts/pdc/stage_to_pdc.py | 33 +- .../scripts/pdc/submit_pdc_matrix.py | 10 +- .../scripts/prepare_a100_bundle.py | 6 +- .../scripts/prepare_data.py | 6 +- .../scripts/render_report.py | 6 +- .../scripts/run_a100_plan.py | 2 +- .../scripts/run_method.py | 6 +- .../scripts/run_pyxenium_smoke.py | 6 +- .../scripts/smoke_core.py | 6 +- .../scripts/stage_to_a100.py | 0 benchmarking/gmi_pdc/README.md | 6 +- docs/api/cci.md | 11 + docs/api/index.md | 8 +- docs/api/ligand_receptor.md | 11 - docs/guides/gmi-contour.md | 2 +- docs/index.md | 6 +- .../{ligand_receptor.ipynb => cci.ipynb} | 44 +- ...or_benchmarking.md => cci_benchmarking.md} | 16 +- ...{ligand_receptor_index.md => cci_index.md} | 19 +- docs/tutorials/contour_boundary_ecology.ipynb | 2 +- docs/tutorials/index.md | 10 +- .../multimodal_bmnet_he_morphology_pdc.md | 4 +- .../tutorials/multimodal_rna_contour_he.ipynb | 2 +- docs/tutorials/pathway.ipynb | 4 +- .../atera-contour-boundary-ecology.md | 2 +- docs/workflows/atera-contour-gmi.md | 2 +- ...k.md => atera-wta-breast-cci-benchmark.md} | 40 +- docs/workflows/atera-wta-breast-topology.md | 2 +- docs/workflows/index.md | 2 +- ...tics.csv => cci_component_diagnostics.csv} | 2 +- ...res.csv => cci_sender_receiver_scores.csv} | 2 +- ...otspot_cells.csv => cci_hotspot_cells.csv} | 0 ...ells.parquet => cci_hotspot_cells.parquet} | Bin ...ot_overlay.pdf => cci_hotspot_overlay.pdf} | Bin ...ot_overlay.png => cci_hotspot_overlay.png} | Bin ...ry_heatmap.pdf => cci_summary_heatmap.pdf} | Bin ...ry_heatmap.png => cci_summary_heatmap.png} | Bin .../atera_wta_breast_topology/summary.json | 76 +- .../code/atera_wta_breast_topology.ipynb | 14 +- src/pyXenium/__init__.py | 8 +- src/pyXenium/__main__.py | 184 ++-- src/pyXenium/_topology_core.py | 8 +- src/pyXenium/analysis/__init__.py | 12 +- ...d_receptor_topology.py => cci_topology.py} | 8 +- src/pyXenium/benchmarking/__init__.py | 30 +- .../benchmarking/{lr_a100.py => cci_a100.py} | 645 +++++++++++++- .../{lr_adapters.py => cci_adapters.py} | 803 +++++++++++++++--- .../{lr_atera.py => cci_atera.py} | 48 +- src/pyXenium/cci/__init__.py | 5 + .../{ligand_receptor => cci}/_analysis.py | 58 +- src/pyXenium/contour/_feature_table.py | 28 +- src/pyXenium/gmi/_dataset.py | 2 +- src/pyXenium/gmi/_pdc.py | 6 +- src/pyXenium/ligand_receptor/__init__.py | 5 - .../multimodal/contour_boundary_ecology.py | 18 +- src/pyXenium/validation/__init__.py | 4 +- .../validation/atera_wta_breast_topology.py | 57 +- ...hmark_cli.py => test_cci_benchmark_cli.py} | 84 +- ...nchmarking.py => test_cci_benchmarking.py} | 236 +++-- tests/test_cli.py | 6 +- tests/test_gmi_pdc_plan.py | 10 +- tests/test_pdc_benchmark_scripts.py | 6 +- tests/test_topology_analysis.py | 30 +- tests/test_validation_module.py | 8 +- 113 files changed, 2202 insertions(+), 919 deletions(-) rename benchmarking/{lr_2026_atera => cci_2026_atera}/README.md (66%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/configs/benchmark.yaml (79%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/configs/canonical_axes.yaml (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/configs/methods.yaml (70%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/configs/pathways.yaml (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/data/.gitkeep (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/envs/bootstrap_cellchat_mainline.R (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/envs/bootstrap_env.py (98%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-cellagentchat.yml => cci_2026_atera/envs/pyx-cci-cellagentchat.yml} (81%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-cellnest.yml => cci_2026_atera/envs/pyx-cci-cellnest.yml} (84%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-cellphonedb.yml => cci_2026_atera/envs/pyx-cci-cellphonedb.yml} (85%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-commot.yml => cci_2026_atera/envs/pyx-cci-commot.yml} (86%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-laris.yml => cci_2026_atera/envs/pyx-cci-laris.yml} (88%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-liana.yml => cci_2026_atera/envs/pyx-cci-liana.yml} (88%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-prep.yml => cci_2026_atera/envs/pyx-cci-prep.yml} (94%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-pyxenium.yml => cci_2026_atera/envs/pyx-cci-pyxenium.yml} (92%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-scild.yml => cci_2026_atera/envs/pyx-cci-scild.yml} (89%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-spatialdm.yml => cci_2026_atera/envs/pyx-cci-spatialdm.yml} (86%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-squidpy.yml => cci_2026_atera/envs/pyx-cci-squidpy.yml} (89%) rename benchmarking/{lr_2026_atera/envs/pyx-lr-stlearn.yml => cci_2026_atera/envs/pyx-cci-stlearn.yml} (88%) rename benchmarking/{lr_2026_atera/envs/r-lr-cellchat.yml => cci_2026_atera/envs/r-cci-cellchat.yml} (97%) rename benchmarking/{lr_2026_atera/envs/r-lr-giotto.yml => cci_2026_atera/envs/r-cci-giotto.yml} (86%) rename benchmarking/{lr_2026_atera/envs/r-lr-niches.yml => cci_2026_atera/envs/r-cci-niches.yml} (86%) rename benchmarking/{lr_2026_atera/envs/r-lr-spatalk.yml => cci_2026_atera/envs/r-cci-spatalk.yml} (86%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/logs/.gitkeep (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/reports/.gitkeep (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/results/.gitkeep (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/python/run_commot.py (87%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/python/run_liana.py (85%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/python/run_method_stub.py (95%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/python/run_pyxenium.py (85%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/python/run_squidpy.py (86%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/r/run_cellchat.R (98%) rename benchmarking/{lr_2026_atera/runners/r/run_external_lr_method.R => cci_2026_atera/runners/r/run_external_cci_method.R} (92%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/r/run_giotto.R (93%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/r/run_method_stub.R (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/r/run_niches.R (91%) rename benchmarking/{lr_2026_atera/runners/r/run_r_lr_utils.R => cci_2026_atera/runners/r/run_r_cci_utils.R} (94%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runners/r/run_spatalk.R (92%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/runs/.gitkeep (100%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/aggregate_results.py (96%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/collect_a100_results.py (97%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/create_env.py (98%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/finalize_a100_full_common.py (97%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/pdc/collect_pdc_results.py (94%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/pdc/monitor_pdc_jobs.py (95%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/pdc/prepare_pdc_bundle.sh (70%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/pdc/stage_to_pdc.py (92%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/pdc/submit_pdc_matrix.py (97%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/prepare_a100_bundle.py (93%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/prepare_data.py (90%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/render_report.py (96%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/run_a100_plan.py (95%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/run_method.py (92%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/run_pyxenium_smoke.py (88%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/smoke_core.py (87%) rename benchmarking/{lr_2026_atera => cci_2026_atera}/scripts/stage_to_a100.py (100%) create mode 100644 docs/api/cci.md delete mode 100644 docs/api/ligand_receptor.md rename docs/tutorials/{ligand_receptor.ipynb => cci.ipynb} (99%) rename docs/tutorials/{ligand_receptor_benchmarking.md => cci_benchmarking.md} (88%) rename docs/tutorials/{ligand_receptor_index.md => cci_index.md} (53%) rename docs/workflows/{atera-wta-breast-lr-benchmark.md => atera-wta-breast-cci-benchmark.md} (64%) rename manuscript/atera_wta_breast_topology/{lr_component_diagnostics.csv => cci_component_diagnostics.csv} (99%) rename manuscript/atera_wta_breast_topology/{lr_sender_receiver_scores.csv => cci_sender_receiver_scores.csv} (99%) rename manuscript/atera_wta_breast_topology/figures/{lr_hotspot_cells.csv => cci_hotspot_cells.csv} (100%) rename manuscript/atera_wta_breast_topology/figures/{lr_hotspot_cells.parquet => cci_hotspot_cells.parquet} (100%) rename manuscript/atera_wta_breast_topology/figures/{lr_hotspot_overlay.pdf => cci_hotspot_overlay.pdf} (100%) rename manuscript/atera_wta_breast_topology/figures/{lr_hotspot_overlay.png => cci_hotspot_overlay.png} (100%) rename manuscript/atera_wta_breast_topology/figures/{lr_summary_heatmap.pdf => cci_summary_heatmap.pdf} (100%) rename manuscript/atera_wta_breast_topology/figures/{lr_summary_heatmap.png => cci_summary_heatmap.png} (100%) rename src/pyXenium/analysis/{ligand_receptor_topology.py => cci_topology.py} (53%) rename src/pyXenium/benchmarking/{lr_a100.py => cci_a100.py} (72%) rename src/pyXenium/benchmarking/{lr_adapters.py => cci_adapters.py} (68%) rename src/pyXenium/benchmarking/{lr_atera.py => cci_atera.py} (96%) create mode 100644 src/pyXenium/cci/__init__.py rename src/pyXenium/{ligand_receptor => cci}/_analysis.py (85%) delete mode 100644 src/pyXenium/ligand_receptor/__init__.py rename tests/{test_lr_benchmark_cli.py => test_cci_benchmark_cli.py} (90%) rename tests/{test_lr_benchmarking.py => test_cci_benchmarking.py} (80%) diff --git a/.gitignore b/.gitignore index 67aca49..e24a55c 100644 --- a/.gitignore +++ b/.gitignore @@ -8,14 +8,14 @@ build/ dist/ docs/_build/ docs/api/generated/ -benchmarking/lr_2026_atera/data/* -!benchmarking/lr_2026_atera/data/.gitkeep -benchmarking/lr_2026_atera/logs/* -!benchmarking/lr_2026_atera/logs/.gitkeep -benchmarking/lr_2026_atera/results/* -!benchmarking/lr_2026_atera/results/.gitkeep -benchmarking/lr_2026_atera/reports/* -!benchmarking/lr_2026_atera/reports/.gitkeep -benchmarking/lr_2026_atera/runs/* -!benchmarking/lr_2026_atera/runs/.gitkeep -benchmarking/lr_2026_atera/pdc_collected/ +benchmarking/cci_2026_atera/data/* +!benchmarking/cci_2026_atera/data/.gitkeep +benchmarking/cci_2026_atera/logs/* +!benchmarking/cci_2026_atera/logs/.gitkeep +benchmarking/cci_2026_atera/results/* +!benchmarking/cci_2026_atera/results/.gitkeep +benchmarking/cci_2026_atera/reports/* +!benchmarking/cci_2026_atera/reports/.gitkeep +benchmarking/cci_2026_atera/runs/* +!benchmarking/cci_2026_atera/runs/.gitkeep +benchmarking/cci_2026_atera/pdc_collected/ diff --git a/README.md b/README.md index fd71019..5e886f7 100644 --- a/README.md +++ b/README.md @@ -32,7 +32,7 @@ pyXenium is a Python toolkit for **10x Genomics Xenium** with eight feature area - `pyXenium.io`: Xenium artifact loading, partial export recovery, SData I/O, and SpatialData-compatible export. - `pyXenium.multimodal`: canonical RNA + protein loading, joint analysis, immune-resistance scoring, and packaged workflows. -- `pyXenium.ligand_receptor`: topology-native ligand-receptor analysis. +- `pyXenium.cci`: topology-native cell-cell interaction analysis. - `pyXenium.pathway`: pathway topology analysis and pathway activity scoring. - `pyXenium.contour`: contour import, contour expansion, and contour-aware density profiling around polygon annotations. - `pyXenium.gmi`: contour-level GMI modeling for sparse main-effect and interaction discovery in spatial transcriptomics. diff --git a/benchmarking/lr_2026_atera/README.md b/benchmarking/cci_2026_atera/README.md similarity index 66% rename from benchmarking/lr_2026_atera/README.md rename to benchmarking/cci_2026_atera/README.md index 4114b9b..5fa52fb 100644 --- a/benchmarking/lr_2026_atera/README.md +++ b/benchmarking/cci_2026_atera/README.md @@ -1,6 +1,6 @@ -# Atera Xenium LR Benchmark +# Atera Xenium CCI Benchmark -This workspace packages the reproducible benchmark scaffold for the Atera Xenium WTA breast ligand-receptor study. It is designed around isolated per-method environments, a shared frozen input bundle, and a standardized result schema that focuses on biological discovery quality rather than raw method scores. +This workspace packages the reproducible benchmark scaffold for the Atera Xenium WTA breast cell-cell interaction study. It is designed around isolated per-method environments, a shared frozen input bundle, and a standardized result schema that focuses on biological discovery quality rather than raw method scores. ## Layout @@ -8,7 +8,7 @@ This workspace packages the reproducible benchmark scaffold for the Atera Xenium - `envs/`: one environment manifest per method plus bootstrap helpers - `scripts/`: high-level entrypoints to prepare data, create environments, aggregate results, render reports, and stage work to A100 - `runners/`: method-side wrappers that consume the frozen bundle and emit standardized artifacts or run manifests -- `data/`: generated benchmark inputs such as optional `adata_full.h5ad`, `adata_smoke.h5ad`, sparse matrices, and shared LR databases +- `data/`: generated benchmark inputs such as optional `adata_full.h5ad`, `adata_smoke.h5ad`, sparse matrices, and shared CCI resources - `runs/`: per-method execution outputs - `results/`: merged standardized tables and evaluation summaries - `reports/`: markdown reports and method cards @@ -18,14 +18,14 @@ This workspace packages the reproducible benchmark scaffold for the Atera Xenium Create the frozen input bundle: ```powershell -python benchmarking/lr_2026_atera/scripts/prepare_data.py ` +python benchmarking/cci_2026_atera/scripts/prepare_data.py ` --dataset-root "Y:\long\10X_datasets\Xenium\Atera\WTA_Preview_FFPE_Breast_Cancer_outs" ``` For local full-pilot runs, export the full sparse bundle while keeping the full `.h5ad` optional: ```powershell -python benchmarking/lr_2026_atera/scripts/prepare_data.py ` +python benchmarking/cci_2026_atera/scripts/prepare_data.py ` --dataset-root "Y:\long\10X_datasets\Xenium\Atera\WTA_Preview_FFPE_Breast_Cancer_outs" ` --skip-full-h5ad ``` @@ -33,19 +33,19 @@ python benchmarking/lr_2026_atera/scripts/prepare_data.py ` Create and bootstrap the prep environment: ```powershell -python benchmarking/lr_2026_atera/scripts/create_env.py --method pyx-lr-prep +python benchmarking/cci_2026_atera/scripts/create_env.py --method pyx-cci-prep ``` Run the built-in `pyXenium` smoke benchmark: ```powershell -python benchmarking/lr_2026_atera/scripts/run_pyxenium_smoke.py +python benchmarking/cci_2026_atera/scripts/run_pyxenium_smoke.py ``` Dry-run or execute any real adapter through the unified contract: ```powershell -pyxenium benchmark atera-lr run-method ` +pyxenium benchmark atera-cci run-method ` --method squidpy ` --database-mode common-db ` --phase smoke ` @@ -55,50 +55,50 @@ pyxenium benchmark atera-lr run-method ` Run the first-wave core smoke panel: ```powershell -pyxenium benchmark atera-lr smoke-core ` +pyxenium benchmark atera-cci smoke-core ` --methods pyxenium,squidpy,liana,commot,cellchat ` --database-mode common-db ` - --max-lr-pairs 50 + --max-cci-pairs 50 ``` Aggregate standardized result tables and build a report: ```powershell -python benchmarking/lr_2026_atera/scripts/aggregate_results.py -python benchmarking/lr_2026_atera/scripts/render_report.py +python benchmarking/cci_2026_atera/scripts/aggregate_results.py +python benchmarking/cci_2026_atera/scripts/render_report.py ``` Generate A100 staging commands: ```powershell -python benchmarking/lr_2026_atera/scripts/stage_to_a100.py ` +python benchmarking/cci_2026_atera/scripts/stage_to_a100.py ` --plan-only ` --remote-xenium-root /mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs ` - --remote-root /data/taobo.hu/pyxenium_lr_benchmark_2026-04 + --remote-root /data/taobo.hu/pyxenium_cci_benchmark_2026-04 ``` -Build the A100 full-run plan. The generated plan reads the original Xenium export from the read-only `/mnt` path and writes the full sparse bundle, logs, runs, results, and reports only under `/data/taobo.hu/pyxenium_lr_benchmark_2026-04`: +Build the A100 full-run plan. The generated plan reads the original Xenium export from the read-only `/mnt` path and writes the full sparse bundle, logs, runs, results, and reports only under `/data/taobo.hu/pyxenium_cci_benchmark_2026-04`: ```powershell -python benchmarking/lr_2026_atera/scripts/prepare_a100_bundle.py ` +python benchmarking/cci_2026_atera/scripts/prepare_a100_bundle.py ` --methods pyxenium,squidpy,liana,commot,cellchat ` --phase full ` --database-mode common-db ` --remote-xenium-root /mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs ` - --remote-root /data/taobo.hu/pyxenium_lr_benchmark_2026-04 + --remote-root /data/taobo.hu/pyxenium_cci_benchmark_2026-04 ``` Dry-run the A100 job manifest: ```powershell -python benchmarking/lr_2026_atera/scripts/run_a100_plan.py ` - --plan-json benchmarking/lr_2026_atera/logs/a100_bundle_plan.json +python benchmarking/cci_2026_atera/scripts/run_a100_plan.py ` + --plan-json benchmarking/cci_2026_atera/logs/a100_bundle_plan.json ``` Generate result recovery commands: ```powershell -python benchmarking/lr_2026_atera/scripts/collect_a100_results.py ` +python benchmarking/cci_2026_atera/scripts/collect_a100_results.py ` --host your-a100-host ` --user taobo.hu ` --since-last @@ -107,39 +107,39 @@ python benchmarking/lr_2026_atera/scripts/collect_a100_results.py ` Build the second-wave all-method A100 smoke matrix. This creates env-audit and smoke jobs for `SpatialDM`, `stLearn`, `Giotto`, `LARIS`, `CellPhoneDB`, `SpaTalk`, `NICHES`, `CellNEST`, `CellAgentChat`, and `SCILD`, while assigning GPU slots to GPU-heavy methods and keeping every output under `/data`: ```powershell -pyxenium benchmark atera-lr build-a100-matrix ` +pyxenium benchmark atera-cci build-a100-matrix ` --phase smoke ` --methods spatialdm,stlearn,giotto,laris,cellphonedb,spatalk,niches,cellnest,cellagentchat,scild ` - --max-lr-pairs 25 ` + --max-cci-pairs 25 ` --include-bootstrap ` --include-audit ` - --output-json benchmarking/lr_2026_atera/logs/a100_second_wave_smoke_matrix.json + --output-json benchmarking/cci_2026_atera/logs/a100_second_wave_smoke_matrix.json ``` Dry-run submission and monitor collected status: ```powershell -pyxenium benchmark atera-lr submit-a100-matrix ` - --matrix-json benchmarking/lr_2026_atera/logs/a100_second_wave_smoke_matrix.json ` +pyxenium benchmark atera-cci submit-a100-matrix ` + --matrix-json benchmarking/cci_2026_atera/logs/a100_second_wave_smoke_matrix.json ` --job-type env_bootstrap ` --host sscb-a100.scilifelab.se ` --user taobo.hu -pyxenium benchmark atera-lr submit-a100-matrix ` - --matrix-json benchmarking/lr_2026_atera/logs/a100_second_wave_smoke_matrix.json ` +pyxenium benchmark atera-cci submit-a100-matrix ` + --matrix-json benchmarking/cci_2026_atera/logs/a100_second_wave_smoke_matrix.json ` --job-type env_audit ` --host sscb-a100.scilifelab.se ` --user taobo.hu -pyxenium benchmark atera-lr submit-a100-matrix ` - --matrix-json benchmarking/lr_2026_atera/logs/a100_second_wave_smoke_matrix.json ` +pyxenium benchmark atera-cci submit-a100-matrix ` + --matrix-json benchmarking/cci_2026_atera/logs/a100_second_wave_smoke_matrix.json ` --job-type method_run ` --host sscb-a100.scilifelab.se ` --user taobo.hu -pyxenium benchmark atera-lr monitor-a100-jobs ` - --matrix-json benchmarking/lr_2026_atera/logs/a100_second_wave_smoke_matrix.json ` - --output-tsv benchmarking/lr_2026_atera/results/a100_second_wave_smoke_job_status.tsv +pyxenium benchmark atera-cci monitor-a100-jobs ` + --matrix-json benchmarking/cci_2026_atera/logs/a100_second_wave_smoke_matrix.json ` + --output-tsv benchmarking/cci_2026_atera/results/a100_second_wave_smoke_job_status.tsv ``` ## Notes @@ -150,6 +150,6 @@ pyxenium benchmark atera-lr monitor-a100-jobs ` - The second-wave scaffold now includes real/bounded adapters or reproducible method-card runners for `SpatialDM`, `stLearn`, `Giotto`, `LARIS`, `CellPhoneDB`, `SpaTalk`, `NICHES`, `CellNEST`, `CellAgentChat`, and `SCILD`. - Each adapter writes method-native raw artifacts, `params.json`, `run_summary.json`, and a standardized TSV that can be consumed by the existing aggregate/report steps. - The aggregator accepts both `standardized.tsv` and `standardized.tsv.gz`, so edge-level or chunked outputs can be compressed before collection. -- Squidpy is run from its isolated `pyx-lr-squidpy` environment, which pins `zarr<3` to avoid the `ome-zarr`/`FSStore` import conflict seen in some base environments. +- Squidpy is run from its isolated `pyx-cci-squidpy` environment, which pins `zarr<3` to avoid the `ome-zarr`/`FSStore` import conflict seen in some base environments. - A100 planning never stores passwords or hard-codes hosts. Use `--plan-only` without host/user for a portable plan, then supply SSH details only when staging or collecting results. -- On A100, `/mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs` is treated as read-only. The stage/job manifest includes a path-safety check that flags any output path under `/mnt`; all writable paths are organized under `/data/taobo.hu/pyxenium_lr_benchmark_2026-04`. +- On A100, `/mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs` is treated as read-only. The stage/job manifest includes a path-safety check that flags any output path under `/mnt`; all writable paths are organized under `/data/taobo.hu/pyxenium_cci_benchmark_2026-04`. diff --git a/benchmarking/lr_2026_atera/configs/benchmark.yaml b/benchmarking/cci_2026_atera/configs/benchmark.yaml similarity index 79% rename from benchmarking/lr_2026_atera/configs/benchmark.yaml rename to benchmarking/cci_2026_atera/configs/benchmark.yaml index 95b5826..3c2f99a 100644 --- a/benchmarking/lr_2026_atera/configs/benchmark.yaml +++ b/benchmarking/cci_2026_atera/configs/benchmark.yaml @@ -1,10 +1,10 @@ -benchmark_name: atera_xenium_lr_2026 +benchmark_name: atera_xenium_cci_2026 dataset_root: Y:\long\10X_datasets\Xenium\Atera\WTA_Preview_FFPE_Breast_Cancer_outs tbc_results: Y:\long\10X_datasets\Xenium\Atera\WTA_Preview_FFPE_Breast_Cancer_outs\sfplot_tbc_formal_wta\results smoke_n_cells: 20000 seed: 0 -local_env_root: D:\GitHub\pyXenium\.envs\lr_benchmark -a100_remote_root: /data/taobo.hu/pyxenium_lr_benchmark_2026-04 +local_env_root: D:\GitHub\pyXenium\.envs\cci_benchmark +a100_remote_root: /data/taobo.hu/pyxenium_cci_benchmark_2026-04 score_weights: canonical_recovery: 0.30 spatial_coherence: 0.25 diff --git a/benchmarking/lr_2026_atera/configs/canonical_axes.yaml b/benchmarking/cci_2026_atera/configs/canonical_axes.yaml similarity index 100% rename from benchmarking/lr_2026_atera/configs/canonical_axes.yaml rename to benchmarking/cci_2026_atera/configs/canonical_axes.yaml diff --git a/benchmarking/lr_2026_atera/configs/methods.yaml b/benchmarking/cci_2026_atera/configs/methods.yaml similarity index 70% rename from benchmarking/lr_2026_atera/configs/methods.yaml rename to benchmarking/cci_2026_atera/configs/methods.yaml index 938a4cb..eb8ee37 100644 --- a/benchmarking/lr_2026_atera/configs/methods.yaml +++ b/benchmarking/cci_2026_atera/configs/methods.yaml @@ -1,10 +1,10 @@ methods: - slug: pyxenium - display_name: pyXenium topology LR + display_name: pyXenium TopoLink-CCI language: python status: implemented - env_name: pyx-lr-pyxenium - env_file: envs/pyx-lr-pyxenium.yml + env_name: pyx-cci-pyxenium + env_file: envs/pyx-cci-pyxenium.yml runner: runners/python/run_pyxenium.py default_phase: smoke resolution: celltype_pair @@ -19,8 +19,8 @@ methods: display_name: CellChat v3 / Spatial CellChat language: r status: adapter-implemented - env_name: r-lr-cellchat - env_file: envs/r-lr-cellchat.yml + env_name: r-cci-cellchat + env_file: envs/r-cci-cellchat.yml runner: runners/r/run_cellchat.R default_phase: smoke resolution: celltype_pair @@ -44,8 +44,8 @@ methods: display_name: COMMOT language: python status: adapter-implemented - env_name: pyx-lr-commot - env_file: envs/pyx-lr-commot.yml + env_name: pyx-cci-commot + env_file: envs/pyx-cci-commot.yml runner: runners/python/run_commot.py default_phase: smoke resolution: cell_pair @@ -62,11 +62,11 @@ methods: display_name: LIANA+ bivariate language: python status: adapter-implemented - env_name: pyx-lr-liana - env_file: envs/pyx-lr-liana.yml + env_name: pyx-cci-liana + env_file: envs/pyx-cci-liana.yml runner: runners/python/run_liana.py default_phase: smoke - resolution: local_lr + resolution: local_cci preferred_platform: local a100_preferred: false supports_native_db: true @@ -83,11 +83,11 @@ methods: display_name: SpatialDM language: python status: adapter-implemented - env_name: pyx-lr-spatialdm - env_file: envs/pyx-lr-spatialdm.yml + env_name: pyx-cci-spatialdm + env_file: envs/pyx-cci-spatialdm.yml runner: scripts/run_method.py default_phase: smoke - resolution: local_lr + resolution: local_cci preferred_platform: local a100_preferred: false supports_native_db: true @@ -102,11 +102,11 @@ methods: display_name: stLearn CCI language: python status: adapter-implemented - env_name: pyx-lr-stlearn - env_file: envs/pyx-lr-stlearn.yml + env_name: pyx-cci-stlearn + env_file: envs/pyx-cci-stlearn.yml runner: scripts/run_method.py default_phase: smoke - resolution: local_lr + resolution: local_cci preferred_platform: local a100_preferred: false supports_native_db: true @@ -120,8 +120,8 @@ methods: display_name: Giotto spatCellCellcom language: r status: adapter-implemented - env_name: r-lr-giotto - env_file: envs/r-lr-giotto.yml + env_name: r-cci-giotto + env_file: envs/r-cci-giotto.yml runner: runners/r/run_giotto.R default_phase: smoke resolution: celltype_pair @@ -140,8 +140,8 @@ methods: display_name: Squidpy ligrec language: python status: adapter-implemented - env_name: pyx-lr-squidpy - env_file: envs/pyx-lr-squidpy.yml + env_name: pyx-cci-squidpy + env_file: envs/pyx-cci-squidpy.yml runner: runners/python/run_squidpy.py default_phase: smoke resolution: celltype_pair @@ -159,8 +159,8 @@ methods: display_name: SpaTalk language: r status: adapter-implemented - env_name: r-lr-spatalk - env_file: envs/r-lr-spatalk.yml + env_name: r-cci-spatalk + env_file: envs/r-cci-spatalk.yml runner: runners/r/run_spatalk.R default_phase: smoke resolution: cell_pair @@ -178,9 +178,9 @@ methods: - slug: cellnest display_name: CellNEST language: python - status: adapter-pending - env_name: pyx-lr-cellnest - env_file: envs/pyx-lr-cellnest.yml + status: adapter-implemented + env_name: pyx-cci-cellnest + env_file: envs/pyx-cci-cellnest.yml runner: scripts/run_method.py default_phase: smoke resolution: cell_pair @@ -189,15 +189,22 @@ methods: supports_native_db: true supports_common_db: true install: - pip_git: - - git+https://github.com/schwartzlab-methods/CellNEST.git + source_git: + - https://github.com/schwartzlab-methods/CellNEST.git + source_commit: 2737fa8f54952b4b35a540f6070655a69f2c4999 + container: + - library://fatema/collection/cellnest_image.sif:latest + pip: + - PyYAML>=6.0 + - zarr>=2.16,<3 + notes: Official implementation is source-layout based; clone under external_src/cellnest and prefer Apptainer/Singularity for torch-geometric compatibility; source Python rebuild env installs pyXenium runtime deps without allowing zarr>=3. - slug: cellagentchat display_name: CellAgentChat language: python - status: adapter-pending - env_name: pyx-lr-cellagentchat - env_file: envs/pyx-lr-cellagentchat.yml + status: adapter-implemented + env_name: pyx-cci-cellagentchat + env_file: envs/pyx-cci-cellagentchat.yml runner: scripts/run_method.py default_phase: smoke resolution: cell_pair @@ -206,15 +213,24 @@ methods: supports_native_db: true supports_common_db: true install: - pip_git: - - git+https://github.com/mcgilldinglab/CellAgentChat.git + source_git: + - https://github.com/mcgilldinglab/CellAgentChat.git + source_commit: 37e51980cb9ba87684993d8bdae26feac8806bae + pythonpath: external_src/cellagentchat/src + pip: + - PyYAML>=6.0 + - numpy==1.26.4 + - zarr>=2.16,<3 + - Mesa==1.0.0 + - pyslingshot==0.0.2 + notes: Use source PYTHONPATH instead of relying on a package import name; the adapter drives tutorial modules directly; full common-db runs are split into CCI chunks and merged before final scoring; torch-scatter/torch-sparse are installed from the matching PyG wheel index. - slug: scild display_name: SCILD language: python - status: adapter-pending - env_name: pyx-lr-scild - env_file: envs/pyx-lr-scild.yml + status: adapter-implemented + env_name: pyx-cci-scild + env_file: envs/pyx-cci-scild.yml runner: scripts/run_method.py default_phase: appendix resolution: cell_pair @@ -225,6 +241,14 @@ methods: install: source_git: - https://github.com/jiatingyu-amss/SCILD.git + source_commit: 683515043df1878f3069c4dd5f887abb5c8976bd + pythonpath: external_src/scild + pip: + - PyYAML>=6.0 + - numpy==1.26.4 + - scipy==1.11.4 + - zarr>=2.16,<3 + - commot==0.0.3 docs: - https://scilddocs.readthedocs.io notes: Official implementation is source-layout based rather than a standard pip package; clone under external_src/scild and run via PYTHONPATH against Models.SCILD_main. @@ -233,8 +257,8 @@ methods: display_name: NICHES language: r status: adapter-implemented - env_name: r-lr-niches - env_file: envs/r-lr-niches.yml + env_name: r-cci-niches + env_file: envs/r-cci-niches.yml runner: runners/r/run_niches.R default_phase: appendix resolution: cell_pair @@ -253,8 +277,8 @@ methods: display_name: CellPhoneDB v5 baseline language: python status: adapter-implemented - env_name: pyx-lr-cellphonedb - env_file: envs/pyx-lr-cellphonedb.yml + env_name: pyx-cci-cellphonedb + env_file: envs/pyx-cci-cellphonedb.yml runner: scripts/run_method.py default_phase: smoke resolution: celltype_pair @@ -271,8 +295,8 @@ methods: display_name: LARIS language: python status: adapter-implemented - env_name: pyx-lr-laris - env_file: envs/pyx-lr-laris.yml + env_name: pyx-cci-laris + env_file: envs/pyx-cci-laris.yml runner: scripts/run_method.py default_phase: smoke resolution: celltype_pair @@ -289,8 +313,8 @@ methods: display_name: Benchmark data prep language: python status: implemented - env_name: pyx-lr-prep - env_file: envs/pyx-lr-prep.yml + env_name: pyx-cci-prep + env_file: envs/pyx-cci-prep.yml runner: scripts/prepare_data.py default_phase: prep resolution: none diff --git a/benchmarking/lr_2026_atera/configs/pathways.yaml b/benchmarking/cci_2026_atera/configs/pathways.yaml similarity index 100% rename from benchmarking/lr_2026_atera/configs/pathways.yaml rename to benchmarking/cci_2026_atera/configs/pathways.yaml diff --git a/benchmarking/lr_2026_atera/data/.gitkeep b/benchmarking/cci_2026_atera/data/.gitkeep similarity index 100% rename from benchmarking/lr_2026_atera/data/.gitkeep rename to benchmarking/cci_2026_atera/data/.gitkeep diff --git a/benchmarking/lr_2026_atera/envs/bootstrap_cellchat_mainline.R b/benchmarking/cci_2026_atera/envs/bootstrap_cellchat_mainline.R similarity index 100% rename from benchmarking/lr_2026_atera/envs/bootstrap_cellchat_mainline.R rename to benchmarking/cci_2026_atera/envs/bootstrap_cellchat_mainline.R diff --git a/benchmarking/lr_2026_atera/envs/bootstrap_env.py b/benchmarking/cci_2026_atera/envs/bootstrap_env.py similarity index 98% rename from benchmarking/lr_2026_atera/envs/bootstrap_env.py rename to benchmarking/cci_2026_atera/envs/bootstrap_env.py index 6d006d7..778b291 100644 --- a/benchmarking/lr_2026_atera/envs/bootstrap_env.py +++ b/benchmarking/cci_2026_atera/envs/bootstrap_env.py @@ -56,7 +56,7 @@ def main() -> None: args = parser.parse_args() repo_root = Path(args.repo_root).resolve() - benchmark_root = Path(args.benchmark_root).resolve() if args.benchmark_root else repo_root / "benchmarking" / "lr_2026_atera" + benchmark_root = Path(args.benchmark_root).resolve() if args.benchmark_root else repo_root / "benchmarking" / "cci_2026_atera" methods_path = Path(args.methods_config) if args.methods_config else benchmark_root / "configs" / "methods.yaml" methods = yaml.safe_load(methods_path.read_text(encoding="utf-8")).get("methods", []) method = next((item for item in methods if item.get("slug") == args.method or item.get("env_name") == args.method), None) diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-cellagentchat.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-cellagentchat.yml similarity index 81% rename from benchmarking/lr_2026_atera/envs/pyx-lr-cellagentchat.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-cellagentchat.yml index abee88e..b71f635 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-cellagentchat.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-cellagentchat.yml @@ -1,4 +1,4 @@ -name: pyx-lr-cellagentchat +name: pyx-cci-cellagentchat channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-cellnest.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-cellnest.yml similarity index 84% rename from benchmarking/lr_2026_atera/envs/pyx-lr-cellnest.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-cellnest.yml index 74c35f7..6548ae0 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-cellnest.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-cellnest.yml @@ -1,4 +1,4 @@ -name: pyx-lr-cellnest +name: pyx-cci-cellnest channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-cellphonedb.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-cellphonedb.yml similarity index 85% rename from benchmarking/lr_2026_atera/envs/pyx-lr-cellphonedb.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-cellphonedb.yml index f862468..c1a4890 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-cellphonedb.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-cellphonedb.yml @@ -1,4 +1,4 @@ -name: pyx-lr-cellphonedb +name: pyx-cci-cellphonedb channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-commot.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-commot.yml similarity index 86% rename from benchmarking/lr_2026_atera/envs/pyx-lr-commot.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-commot.yml index e0ec713..f791689 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-commot.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-commot.yml @@ -1,4 +1,4 @@ -name: pyx-lr-commot +name: pyx-cci-commot channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-laris.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-laris.yml similarity index 88% rename from benchmarking/lr_2026_atera/envs/pyx-lr-laris.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-laris.yml index 647bbbc..864ad5e 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-laris.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-laris.yml @@ -1,4 +1,4 @@ -name: pyx-lr-laris +name: pyx-cci-laris channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-liana.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-liana.yml similarity index 88% rename from benchmarking/lr_2026_atera/envs/pyx-lr-liana.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-liana.yml index bdeb190..f25da8f 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-liana.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-liana.yml @@ -1,4 +1,4 @@ -name: pyx-lr-liana +name: pyx-cci-liana channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-prep.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-prep.yml similarity index 94% rename from benchmarking/lr_2026_atera/envs/pyx-lr-prep.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-prep.yml index 7ae80ed..b9adaaf 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-prep.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-prep.yml @@ -1,4 +1,4 @@ -name: pyx-lr-prep +name: pyx-cci-prep channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-pyxenium.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-pyxenium.yml similarity index 92% rename from benchmarking/lr_2026_atera/envs/pyx-lr-pyxenium.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-pyxenium.yml index dcc178a..4843eeb 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-pyxenium.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-pyxenium.yml @@ -1,4 +1,4 @@ -name: pyx-lr-pyxenium +name: pyx-cci-pyxenium channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-scild.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-scild.yml similarity index 89% rename from benchmarking/lr_2026_atera/envs/pyx-lr-scild.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-scild.yml index 0156f31..8c0d1bc 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-scild.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-scild.yml @@ -1,4 +1,4 @@ -name: pyx-lr-scild +name: pyx-cci-scild channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-spatialdm.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-spatialdm.yml similarity index 86% rename from benchmarking/lr_2026_atera/envs/pyx-lr-spatialdm.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-spatialdm.yml index 98b1ea0..bf379c7 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-spatialdm.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-spatialdm.yml @@ -1,4 +1,4 @@ -name: pyx-lr-spatialdm +name: pyx-cci-spatialdm channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-squidpy.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-squidpy.yml similarity index 89% rename from benchmarking/lr_2026_atera/envs/pyx-lr-squidpy.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-squidpy.yml index 9806cfa..99fda0d 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-squidpy.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-squidpy.yml @@ -1,4 +1,4 @@ -name: pyx-lr-squidpy +name: pyx-cci-squidpy channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/pyx-lr-stlearn.yml b/benchmarking/cci_2026_atera/envs/pyx-cci-stlearn.yml similarity index 88% rename from benchmarking/lr_2026_atera/envs/pyx-lr-stlearn.yml rename to benchmarking/cci_2026_atera/envs/pyx-cci-stlearn.yml index 2be499d..45d1c98 100644 --- a/benchmarking/lr_2026_atera/envs/pyx-lr-stlearn.yml +++ b/benchmarking/cci_2026_atera/envs/pyx-cci-stlearn.yml @@ -1,4 +1,4 @@ -name: pyx-lr-stlearn +name: pyx-cci-stlearn channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/r-lr-cellchat.yml b/benchmarking/cci_2026_atera/envs/r-cci-cellchat.yml similarity index 97% rename from benchmarking/lr_2026_atera/envs/r-lr-cellchat.yml rename to benchmarking/cci_2026_atera/envs/r-cci-cellchat.yml index 07082be..a79c47e 100644 --- a/benchmarking/lr_2026_atera/envs/r-lr-cellchat.yml +++ b/benchmarking/cci_2026_atera/envs/r-cci-cellchat.yml @@ -1,4 +1,4 @@ -name: r-lr-cellchat +name: r-cci-cellchat channels: - conda-forge - bioconda diff --git a/benchmarking/lr_2026_atera/envs/r-lr-giotto.yml b/benchmarking/cci_2026_atera/envs/r-cci-giotto.yml similarity index 86% rename from benchmarking/lr_2026_atera/envs/r-lr-giotto.yml rename to benchmarking/cci_2026_atera/envs/r-cci-giotto.yml index a78e695..77ac87d 100644 --- a/benchmarking/lr_2026_atera/envs/r-lr-giotto.yml +++ b/benchmarking/cci_2026_atera/envs/r-cci-giotto.yml @@ -1,4 +1,4 @@ -name: r-lr-giotto +name: r-cci-giotto channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/r-lr-niches.yml b/benchmarking/cci_2026_atera/envs/r-cci-niches.yml similarity index 86% rename from benchmarking/lr_2026_atera/envs/r-lr-niches.yml rename to benchmarking/cci_2026_atera/envs/r-cci-niches.yml index f77760f..e5382d1 100644 --- a/benchmarking/lr_2026_atera/envs/r-lr-niches.yml +++ b/benchmarking/cci_2026_atera/envs/r-cci-niches.yml @@ -1,4 +1,4 @@ -name: r-lr-niches +name: r-cci-niches channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/envs/r-lr-spatalk.yml b/benchmarking/cci_2026_atera/envs/r-cci-spatalk.yml similarity index 86% rename from benchmarking/lr_2026_atera/envs/r-lr-spatalk.yml rename to benchmarking/cci_2026_atera/envs/r-cci-spatalk.yml index 4d25207..7abe51f 100644 --- a/benchmarking/lr_2026_atera/envs/r-lr-spatalk.yml +++ b/benchmarking/cci_2026_atera/envs/r-cci-spatalk.yml @@ -1,4 +1,4 @@ -name: r-lr-spatalk +name: r-cci-spatalk channels: - conda-forge dependencies: diff --git a/benchmarking/lr_2026_atera/logs/.gitkeep b/benchmarking/cci_2026_atera/logs/.gitkeep similarity index 100% rename from benchmarking/lr_2026_atera/logs/.gitkeep rename to benchmarking/cci_2026_atera/logs/.gitkeep diff --git a/benchmarking/lr_2026_atera/reports/.gitkeep b/benchmarking/cci_2026_atera/reports/.gitkeep similarity index 100% rename from benchmarking/lr_2026_atera/reports/.gitkeep rename to benchmarking/cci_2026_atera/reports/.gitkeep diff --git a/benchmarking/lr_2026_atera/results/.gitkeep b/benchmarking/cci_2026_atera/results/.gitkeep similarity index 100% rename from benchmarking/lr_2026_atera/results/.gitkeep rename to benchmarking/cci_2026_atera/results/.gitkeep diff --git a/benchmarking/lr_2026_atera/runners/python/run_commot.py b/benchmarking/cci_2026_atera/runners/python/run_commot.py similarity index 87% rename from benchmarking/lr_2026_atera/runners/python/run_commot.py rename to benchmarking/cci_2026_atera/runners/python/run_commot.py index 4f54cc6..dabc64b 100644 --- a/benchmarking/lr_2026_atera/runners/python/run_commot.py +++ b/benchmarking/cci_2026_atera/runners/python/run_commot.py @@ -7,13 +7,13 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Run the COMMOT LR benchmark adapter.") + parser = argparse.ArgumentParser(description="Run the COMMOT CCI benchmark adapter.") parser.add_argument("--input-manifest", required=True) parser.add_argument("--output-dir", required=True) parser.add_argument("--method", default="commot") parser.add_argument("--database-mode", default="common-db") parser.add_argument("--phase", choices=["smoke", "full"], default="smoke") - parser.add_argument("--max-lr-pairs", type=int, default=None) + parser.add_argument("--max-cci-pairs", type=int, default=None) parser.add_argument("--n-perms", type=int, default=100) args = parser.parse_args() @@ -23,7 +23,7 @@ def main() -> None: output_dir=args.output_dir, database_mode=args.database_mode, phase=args.phase, - max_lr_pairs=args.max_lr_pairs, + max_cci_pairs=args.max_cci_pairs, n_perms=args.n_perms, ) print(json.dumps(payload, indent=2)) diff --git a/benchmarking/lr_2026_atera/runners/python/run_liana.py b/benchmarking/cci_2026_atera/runners/python/run_liana.py similarity index 85% rename from benchmarking/lr_2026_atera/runners/python/run_liana.py rename to benchmarking/cci_2026_atera/runners/python/run_liana.py index 4ca4a5f..f5efcff 100644 --- a/benchmarking/lr_2026_atera/runners/python/run_liana.py +++ b/benchmarking/cci_2026_atera/runners/python/run_liana.py @@ -7,13 +7,13 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Run the LIANA+ spatial bivariate LR benchmark adapter.") + parser = argparse.ArgumentParser(description="Run the LIANA+ spatial bivariate CCI benchmark adapter.") parser.add_argument("--input-manifest", required=True) parser.add_argument("--output-dir", required=True) parser.add_argument("--method", default="liana") parser.add_argument("--database-mode", default="common-db") parser.add_argument("--phase", choices=["smoke", "full"], default="smoke") - parser.add_argument("--max-lr-pairs", type=int, default=None) + parser.add_argument("--max-cci-pairs", type=int, default=None) parser.add_argument("--n-perms", type=int, default=100) args = parser.parse_args() @@ -23,7 +23,7 @@ def main() -> None: output_dir=args.output_dir, database_mode=args.database_mode, phase=args.phase, - max_lr_pairs=args.max_lr_pairs, + max_cci_pairs=args.max_cci_pairs, n_perms=args.n_perms, ) print(json.dumps(payload, indent=2)) diff --git a/benchmarking/lr_2026_atera/runners/python/run_method_stub.py b/benchmarking/cci_2026_atera/runners/python/run_method_stub.py similarity index 95% rename from benchmarking/lr_2026_atera/runners/python/run_method_stub.py rename to benchmarking/cci_2026_atera/runners/python/run_method_stub.py index 5270b9e..ab97cf1 100644 --- a/benchmarking/lr_2026_atera/runners/python/run_method_stub.py +++ b/benchmarking/cci_2026_atera/runners/python/run_method_stub.py @@ -6,7 +6,7 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Placeholder runner for third-party Python LR methods.") + parser = argparse.ArgumentParser(description="Placeholder runner for third-party Python CCI methods.") parser.add_argument("--method", required=True) parser.add_argument("--input-manifest", required=True) parser.add_argument("--output-dir", required=True) diff --git a/benchmarking/lr_2026_atera/runners/python/run_pyxenium.py b/benchmarking/cci_2026_atera/runners/python/run_pyxenium.py similarity index 85% rename from benchmarking/lr_2026_atera/runners/python/run_pyxenium.py rename to benchmarking/cci_2026_atera/runners/python/run_pyxenium.py index a267375..259282a 100644 --- a/benchmarking/lr_2026_atera/runners/python/run_pyxenium.py +++ b/benchmarking/cci_2026_atera/runners/python/run_pyxenium.py @@ -7,16 +7,16 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Runner wrapper for the pyXenium LR benchmark adapter.") + parser = argparse.ArgumentParser(description="Runner wrapper for the pyXenium CCI benchmark adapter.") parser.add_argument("--input-manifest", default=None) parser.add_argument("--input-h5ad", default=None) parser.add_argument("--output-dir", required=True) parser.add_argument("--tbc-results", default=None) - parser.add_argument("--lr-panel-path", default=None) + parser.add_argument("--cci-panel-path", default=None) parser.add_argument("--method", default="pyxenium") parser.add_argument("--database-mode", default="common-db") parser.add_argument("--phase", choices=["smoke", "full"], default="smoke") - parser.add_argument("--max-lr-pairs", type=int, default=None) + parser.add_argument("--max-cci-pairs", type=int, default=None) parser.add_argument("--export-figures", action="store_true") args = parser.parse_args() @@ -27,7 +27,7 @@ def main() -> None: output_dir=args.output_dir, database_mode=args.database_mode, phase=args.phase, - max_lr_pairs=args.max_lr_pairs, + max_cci_pairs=args.max_cci_pairs, tbc_results=args.tbc_results, export_figures=args.export_figures, ) @@ -37,7 +37,7 @@ def main() -> None: for name, value in { "--input-h5ad": args.input_h5ad, "--tbc-results": args.tbc_results, - "--lr-panel-path": args.lr_panel_path, + "--cci-panel-path": args.cci_panel_path, }.items() if value is None ] @@ -47,7 +47,7 @@ def main() -> None: input_h5ad=args.input_h5ad, output_dir=args.output_dir, tbc_results=args.tbc_results, - lr_panel_path=args.lr_panel_path, + cci_panel_path=args.cci_panel_path, database_mode=args.database_mode, export_figures=args.export_figures, ) diff --git a/benchmarking/lr_2026_atera/runners/python/run_squidpy.py b/benchmarking/cci_2026_atera/runners/python/run_squidpy.py similarity index 86% rename from benchmarking/lr_2026_atera/runners/python/run_squidpy.py rename to benchmarking/cci_2026_atera/runners/python/run_squidpy.py index 013c110..d5b83c2 100644 --- a/benchmarking/lr_2026_atera/runners/python/run_squidpy.py +++ b/benchmarking/cci_2026_atera/runners/python/run_squidpy.py @@ -7,13 +7,13 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Run the Squidpy ligrec LR benchmark adapter.") + parser = argparse.ArgumentParser(description="Run the Squidpy ligrec CCI benchmark adapter.") parser.add_argument("--input-manifest", required=True) parser.add_argument("--output-dir", required=True) parser.add_argument("--method", default="squidpy") parser.add_argument("--database-mode", default="common-db") parser.add_argument("--phase", choices=["smoke", "full"], default="smoke") - parser.add_argument("--max-lr-pairs", type=int, default=None) + parser.add_argument("--max-cci-pairs", type=int, default=None) parser.add_argument("--n-perms", type=int, default=100) args = parser.parse_args() @@ -23,7 +23,7 @@ def main() -> None: output_dir=args.output_dir, database_mode=args.database_mode, phase=args.phase, - max_lr_pairs=args.max_lr_pairs, + max_cci_pairs=args.max_cci_pairs, n_perms=args.n_perms, ) print(json.dumps(payload, indent=2)) diff --git a/benchmarking/lr_2026_atera/runners/r/run_cellchat.R b/benchmarking/cci_2026_atera/runners/r/run_cellchat.R similarity index 98% rename from benchmarking/lr_2026_atera/runners/r/run_cellchat.R rename to benchmarking/cci_2026_atera/runners/r/run_cellchat.R index 613bef9..02bc073 100644 --- a/benchmarking/lr_2026_atera/runners/r/run_cellchat.R +++ b/benchmarking/cci_2026_atera/runners/r/run_cellchat.R @@ -136,7 +136,7 @@ if (!requireNamespace("CellChat", quietly = TRUE)) fail_run(output_dir, "R packa input_manifest <- opts[["input-manifest"]] %||% fail_run(output_dir, "--input-manifest is required.") database_mode <- opts[["database-mode"]] %||% "common-db" phase <- opts[["phase"]] %||% "smoke" -max_lr_pairs <- opts[["max-lr-pairs"]] +max_cci_pairs <- opts[["max-cci-pairs"]] disable_pathway <- isTRUE(opts[["disable-pathway"]]) manifest <- jsonlite::fromJSON(input_manifest, simplifyVector = FALSE) if (phase == "full") { @@ -155,7 +155,7 @@ write_json(file.path(output_dir, "params.json"), list( phase = phase, input_manifest = input_manifest, output_dir = output_dir, - max_lr_pairs = max_lr_pairs, + max_cci_pairs = max_cci_pairs, disable_pathway = disable_pathway, runner = "run_cellchat.R" )) @@ -182,10 +182,10 @@ cellchat <- tryCatch( ) if (database_mode %in% c("common", "common-db", "smoke-panel")) { - db_path <- if (database_mode == "smoke-panel") manifest$atera_smoke_panel_tsv else manifest$lr_db_common_tsv + db_path <- if (database_mode == "smoke-panel") manifest$atera_smoke_panel_tsv else manifest$cci_resource_common_tsv lr_db <- read.delim(db_path, sep = "\t", stringsAsFactors = FALSE) if (!"pathway" %in% colnames(lr_db)) lr_db$pathway <- "custom" - if (!is.null(max_lr_pairs)) lr_db <- head(lr_db, as.integer(max_lr_pairs)) + if (!is.null(max_cci_pairs)) lr_db <- head(lr_db, as.integer(max_cci_pairs)) cellchat@DB <- create_common_db(lr_db) } else { data(CellChatDB.human, package = "CellChat", envir = environment()) diff --git a/benchmarking/lr_2026_atera/runners/r/run_external_lr_method.R b/benchmarking/cci_2026_atera/runners/r/run_external_cci_method.R similarity index 92% rename from benchmarking/lr_2026_atera/runners/r/run_external_lr_method.R rename to benchmarking/cci_2026_atera/runners/r/run_external_cci_method.R index b3da966..95a61a9 100644 --- a/benchmarking/lr_2026_atera/runners/r/run_external_lr_method.R +++ b/benchmarking/cci_2026_atera/runners/r/run_external_cci_method.R @@ -7,7 +7,7 @@ now_iso <- function() { } activate_method_renv <- function(method, input_manifest = NULL, output_dir = NULL) { - benchmark_root <- Sys.getenv("PYX_LR_BENCHMARK_ROOT", unset = NA_character_) + benchmark_root <- Sys.getenv("PYX_CCI_BENCHMARK_ROOT", unset = NA_character_) if (is.na(benchmark_root) && !is.null(input_manifest) && !is.na(input_manifest)) { benchmark_root <- dirname(dirname(normalizePath(input_manifest, mustWork = FALSE))) } @@ -17,7 +17,7 @@ activate_method_renv <- function(method, input_manifest = NULL, output_dir = NUL if (is.na(benchmark_root)) { return(invisible(FALSE)) } - project_dir <- file.path(benchmark_root, "envs", paste0("r-lr-", method, "_project")) + project_dir <- file.path(benchmark_root, "envs", paste0("r-cci-", method, "_project")) if (!dir.exists(project_dir)) { return(invisible(FALSE)) } @@ -36,7 +36,7 @@ parse_args <- function() { output_dir = NULL, database_mode = "common-db", phase = "smoke", - max_lr_pairs = NULL, + max_cci_pairs = NULL, allow_expression_baseline = FALSE ) i <- 1 @@ -48,7 +48,7 @@ parse_args <- function() { if (key == "--output-dir") out$output_dir <- value if (key == "--database-mode") out$database_mode <- value if (key == "--phase") out$phase <- value - if (key == "--max-lr-pairs") out$max_lr_pairs <- as.integer(value) + if (key == "--max-cci-pairs") out$max_cci_pairs <- as.integer(value) if (key == "--allow-expression-baseline") { out$allow_expression_baseline <- TRUE i <- i + 1 @@ -104,9 +104,9 @@ run_package_present_expression_baseline <- function(opts, available) { started <- Sys.time() manifest <- fromJSON(opts$input_manifest, simplifyVector = FALSE) bundle <- select_bundle(manifest, opts$phase) - lr_path <- manifest$lr_db_common_tsv + lr_path <- manifest$cci_resource_common_tsv if (is.null(lr_path) || !file.exists(lr_path)) { - stop("Manifest lr_db_common_tsv is missing or not readable") + stop("Manifest cci_resource_common_tsv is missing or not readable") } genes <- read.table(bundle$genes_tsv, sep = "\t", header = TRUE, stringsAsFactors = FALSE, quote = "", comment.char = "") @@ -126,18 +126,18 @@ run_package_present_expression_baseline <- function(opts, available) { lr <- read.table(lr_path, sep = "\t", header = TRUE, stringsAsFactors = FALSE, quote = "", comment.char = "") if (!all(c("ligand", "receptor") %in% colnames(lr))) { - stop("LR database must contain ligand and receptor columns") + stop("CCI resource must contain ligand and receptor columns") } lr <- unique(lr[, c("ligand", "receptor"), drop = FALSE]) lr$ligand <- as.character(lr$ligand) lr$receptor <- as.character(lr$receptor) detected <- lr$ligand %in% gene_symbols & lr$receptor %in% gene_symbols lr <- lr[detected, , drop = FALSE] - if (!is.null(opts$max_lr_pairs) && !is.na(opts$max_lr_pairs)) { - lr <- head(lr, opts$max_lr_pairs) + if (!is.null(opts$max_cci_pairs) && !is.na(opts$max_cci_pairs)) { + lr <- head(lr, opts$max_cci_pairs) } if (nrow(lr) == 0) { - stop("No detectable LR pairs remained after filtering") + stop("No detectable CCI pairs remained after filtering") } needed_genes <- unique(c(lr$ligand, lr$receptor)) @@ -190,7 +190,7 @@ run_package_present_expression_baseline <- function(opts, available) { fdr_or_pvalue = NA_real_, resolution = "celltype_pair", spatial_support_type = paste0(opts$method, "_package_present_expression_baseline"), - artifact_path = file.path(opts$output_dir, "raw", paste0(opts$method, "_expression_lr_scores.tsv")), + artifact_path = file.path(opts$output_dir, "raw", paste0(opts$method, "_expression_cci_scores.tsv")), stringsAsFactors = FALSE ) } @@ -202,7 +202,7 @@ run_package_present_expression_baseline <- function(opts, available) { "resolution", "spatial_support_type", "artifact_path" )] - raw_path <- file.path(opts$output_dir, "raw", paste0(opts$method, "_expression_lr_scores.tsv")) + raw_path <- file.path(opts$output_dir, "raw", paste0(opts$method, "_expression_cci_scores.tsv")) std_path <- file.path(opts$output_dir, paste0(opts$method, "_standardized.tsv")) write.table(df, raw_path, sep = "\t", quote = FALSE, row.names = FALSE) write.table(df, std_path, sep = "\t", quote = FALSE, row.names = FALSE) @@ -214,14 +214,14 @@ run_package_present_expression_baseline <- function(opts, available) { database_mode = opts$database_mode, bounded_mode = "package_present_expression_baseline", package_available = available, - n_lr_pairs = nrow(lr), + n_interaction_pairs = nrow(lr), n_rows = nrow(df), standardized_tsv = std_path, raw_artifact = raw_path, input_manifest = opts$input_manifest, output_dir = opts$output_dir, elapsed_seconds = as.numeric(difftime(Sys.time(), started, units = "secs")), - note = "A method package was importable, but the method-specific public API mapping is not finalized; this bounded result uses the shared LR expression baseline and is kept for appendix comparison." + note = "A method package was importable, but the method-specific public API mapping is not finalized; this bounded result uses the shared CCI expression baseline and is kept for appendix comparison." ) write_json(payload, file.path(opts$output_dir, "run_summary.json"), auto_unbox = TRUE, pretty = TRUE) invisible(payload) @@ -280,7 +280,7 @@ main <- function() { allow_expression_baseline = isTRUE(opts$allow_expression_baseline), input_manifest = opts$input_manifest, output_dir = opts$output_dir, - reproduce = paste("conda run --name Rscript", "run_external_lr_method.R", "--method", opts$method) + reproduce = paste("conda run --name Rscript", "run_external_cci_method.R", "--method", opts$method) ) write_json(payload, file.path(opts$output_dir, "run_summary.json"), auto_unbox = TRUE, pretty = TRUE) write_method_card(opts$output_dir, payload) diff --git a/benchmarking/lr_2026_atera/runners/r/run_giotto.R b/benchmarking/cci_2026_atera/runners/r/run_giotto.R similarity index 93% rename from benchmarking/lr_2026_atera/runners/r/run_giotto.R rename to benchmarking/cci_2026_atera/runners/r/run_giotto.R index 0d3db9f..b893528 100644 --- a/benchmarking/lr_2026_atera/runners/r/run_giotto.R +++ b/benchmarking/cci_2026_atera/runners/r/run_giotto.R @@ -1,14 +1,14 @@ args_all <- commandArgs(trailingOnly = FALSE) file_arg <- grep("^--file=", args_all, value = TRUE) script_dir <- if (length(file_arg) > 0) dirname(normalizePath(sub("^--file=", "", file_arg[[1]]))) else getwd() -source(file.path(script_dir, "run_r_lr_utils.R")) +source(file.path(script_dir, "run_r_cci_utils.R")) suppressPackageStartupMessages({ library(jsonlite) library(Matrix) }) -opts <- parse_lr_args() +opts <- parse_cci_args() method <- "giotto" output_dir <- opts[["output-dir"]] %||% stop("--output-dir is required", call. = FALSE) dir.create(output_dir, recursive = TRUE, showWarnings = FALSE) @@ -27,7 +27,7 @@ phase <- opts[["phase"]] %||% "smoke" n_cores <- as.integer(opts[["n-cores"]] %||% 8) k <- as.integer(opts[["k"]] %||% 4) random_iter <- as.integer(opts[["random-iter"]] %||% 100) -max_lr_pairs <- opts[["max-lr-pairs"]] +max_cci_pairs <- opts[["max-cci-pairs"]] max_cells <- opts[["max-cells"]] seed <- as.integer(opts[["seed"]] %||% 1) do_parallel <- isTRUE(opts[["do-parallel"]]) @@ -42,7 +42,7 @@ params <- list( n_cores = n_cores, k = k, random_iter = random_iter, - max_lr_pairs = max_lr_pairs, + max_cci_pairs = max_cci_pairs, max_cells = max_cells, seed = seed, do_parallel = do_parallel, @@ -54,9 +54,9 @@ tryCatch({ manifest <- jsonlite::fromJSON(input_manifest, simplifyVector = FALSE) bundle <- read_sparse_bundle(manifest, phase, max_cells = max_cells, seed = seed) counts <- bundle$counts - lr <- read_lr_database(manifest, database_mode, max_lr_pairs = max_lr_pairs) + lr <- read_cci_resource(manifest, database_mode, max_cci_pairs = max_cci_pairs) lr <- lr[lr$ligand %in% rownames(counts) & lr$receptor %in% rownames(counts), , drop = FALSE] - if (nrow(lr) == 0) stop("No common LR pairs were detectable in the sparse bundle.") + if (nrow(lr) == 0) stop("No common CCI pairs were detectable in the sparse bundle.") cell_metadata <- data.frame( cell_ID = bundle$barcodes, @@ -142,7 +142,7 @@ tryCatch({ phase = phase, raw_tsv = raw_path, standardized_tsv_gz = std_path, - n_lr_pairs = nrow(lr), + n_interaction_pairs = nrow(lr), n_rows = nrow(std), elapsed_seconds = as.numeric(difftime(Sys.time(), started, units = "secs")), package_versions = list( diff --git a/benchmarking/lr_2026_atera/runners/r/run_method_stub.R b/benchmarking/cci_2026_atera/runners/r/run_method_stub.R similarity index 100% rename from benchmarking/lr_2026_atera/runners/r/run_method_stub.R rename to benchmarking/cci_2026_atera/runners/r/run_method_stub.R diff --git a/benchmarking/lr_2026_atera/runners/r/run_niches.R b/benchmarking/cci_2026_atera/runners/r/run_niches.R similarity index 91% rename from benchmarking/lr_2026_atera/runners/r/run_niches.R rename to benchmarking/cci_2026_atera/runners/r/run_niches.R index e82db01..a25e3c6 100644 --- a/benchmarking/lr_2026_atera/runners/r/run_niches.R +++ b/benchmarking/cci_2026_atera/runners/r/run_niches.R @@ -1,14 +1,14 @@ args_all <- commandArgs(trailingOnly = FALSE) file_arg <- grep("^--file=", args_all, value = TRUE) script_dir <- if (length(file_arg) > 0) dirname(normalizePath(sub("^--file=", "", file_arg[[1]]))) else getwd() -source(file.path(script_dir, "run_r_lr_utils.R")) +source(file.path(script_dir, "run_r_cci_utils.R")) suppressPackageStartupMessages({ library(jsonlite) library(Matrix) }) -opts <- parse_lr_args() +opts <- parse_cci_args() method <- "niches" output_dir <- opts[["output-dir"]] %||% stop("--output-dir is required", call. = FALSE) dir.create(output_dir, recursive = TRUE, showWarnings = FALSE) @@ -23,7 +23,7 @@ for (pkg in c("NICHES", "Seurat", "SeuratObject")) { input_manifest <- opts[["input-manifest"]] %||% fail_run(output_dir, method, "--input-manifest is required.") database_mode <- opts[["database-mode"]] %||% "common" phase <- opts[["phase"]] %||% "smoke" -max_lr_pairs <- opts[["max-lr-pairs"]] +max_cci_pairs <- opts[["max-cci-pairs"]] max_cells <- opts[["max-cells"]] seed <- as.integer(opts[["seed"]] %||% 1) k <- as.integer(opts[["k"]] %||% 4) @@ -37,7 +37,7 @@ params <- list( phase = phase, input_manifest = input_manifest, output_dir = output_dir, - max_lr_pairs = max_lr_pairs, + max_cci_pairs = max_cci_pairs, max_cells = max_cells, seed = seed, k = k, @@ -47,7 +47,7 @@ params <- list( ) write_params(output_dir, params) -split_lr_name <- function(x) { +split_interaction_name <- function(x) { dash <- intToUtf8(8212) parts <- strsplit(as.character(x), dash, fixed = TRUE)[[1]] if (length(parts) < 2) parts <- strsplit(as.character(x), "-", fixed = TRUE)[[1]] @@ -80,12 +80,12 @@ aggregate_niches_matrix <- function(mat, metadata, artifact_path, database_mode) merged$sum_score[is.na(merged$sum_score)] <- 0 merged$score_raw <- merged$sum_score / denom[merged$type] - lr_parts <- t(vapply(rownames(mat)[merged$interaction], split_lr_name, character(2))) + interaction_parts <- t(vapply(rownames(mat)[merged$interaction], split_interaction_name, character(2))) data.frame( method = method, database_mode = database_mode, - ligand = lr_parts[, 1], - receptor = lr_parts[, 2], + ligand = interaction_parts[, 1], + receptor = interaction_parts[, 2], sender = senders[merged$type], receiver = receivers[merged$type], score_raw = merged$score_raw, @@ -101,15 +101,15 @@ tryCatch({ manifest <- jsonlite::fromJSON(input_manifest, simplifyVector = FALSE) bundle <- read_sparse_bundle(manifest, phase, max_cells = max_cells, seed = seed) counts <- bundle$counts - lr <- read_lr_database( + lr <- read_cci_resource( manifest, database_mode, - max_lr_pairs = max_lr_pairs, + max_cci_pairs = max_cci_pairs, chunk_id = chunk_id, chunk_size = chunk_size ) lr <- lr[lr$ligand %in% rownames(counts) & lr$receptor %in% rownames(counts), , drop = FALSE] - if (nrow(lr) == 0) stop("No common LR pairs were detectable in the sparse bundle.") + if (nrow(lr) == 0) stop("No common CCI pairs were detectable in the sparse bundle.") custom_lr <- unique(data.frame(ligand = lr$ligand, receptor = lr$receptor, stringsAsFactors = FALSE)) suppressPackageStartupMessages({ @@ -158,7 +158,7 @@ tryCatch({ raw_rds = raw_rds, metadata_tsv = raw_meta, standardized_tsv_gz = std_path, - n_lr_pairs = nrow(lr), + n_interaction_pairs = nrow(lr), n_rows = nrow(std), elapsed_seconds = as.numeric(difftime(Sys.time(), started, units = "secs")), package_versions = list( diff --git a/benchmarking/lr_2026_atera/runners/r/run_r_lr_utils.R b/benchmarking/cci_2026_atera/runners/r/run_r_cci_utils.R similarity index 94% rename from benchmarking/lr_2026_atera/runners/r/run_r_lr_utils.R rename to benchmarking/cci_2026_atera/runners/r/run_r_cci_utils.R index 2e3cd7d..ccd24ae 100644 --- a/benchmarking/lr_2026_atera/runners/r/run_r_lr_utils.R +++ b/benchmarking/cci_2026_atera/runners/r/run_r_cci_utils.R @@ -8,7 +8,7 @@ x } -parse_lr_args <- function(args = commandArgs(trailingOnly = TRUE)) { +parse_cci_args <- function(args = commandArgs(trailingOnly = TRUE)) { parsed <- list() i <- 1 while (i <= length(args)) { @@ -147,14 +147,14 @@ read_sparse_bundle <- function(manifest, phase, max_cells = NULL, seed = 1) { ) } -read_lr_database <- function(manifest, mode, max_lr_pairs = NULL, chunk_id = NULL, chunk_size = NULL) { - db_path <- if (mode %in% c("smoke-panel", "smoke_panel")) manifest$atera_smoke_panel_tsv else manifest$lr_db_common_tsv +read_cci_resource <- function(manifest, mode, max_cci_pairs = NULL, chunk_id = NULL, chunk_size = NULL) { + db_path <- if (mode %in% c("smoke-panel", "smoke_panel")) manifest$atera_smoke_panel_tsv else manifest$cci_resource_common_tsv if (is.null(db_path) || !file.exists(db_path)) { - stop("Manifest LR database path is missing or unreadable.", call. = FALSE) + stop("Manifest CCI resource path is missing or unreadable.", call. = FALSE) } lr <- read.delim(db_path, sep = "\t", stringsAsFactors = FALSE) if (!all(c("ligand", "receptor") %in% colnames(lr))) { - stop("LR database must contain ligand and receptor columns.", call. = FALSE) + stop("CCI resource must contain ligand and receptor columns.", call. = FALSE) } lr$ligand <- as.character(lr$ligand) lr$receptor <- as.character(lr$receptor) @@ -167,8 +167,8 @@ read_lr_database <- function(manifest, mode, max_lr_pairs = NULL, chunk_id = NUL end <- min(nrow(lr), start + chunk_size - 1) if (start > nrow(lr)) lr <- lr[0, , drop = FALSE] else lr <- lr[start:end, , drop = FALSE] } - if (!is.null(max_lr_pairs)) { - lr <- head(lr, as.integer(max_lr_pairs)) + if (!is.null(max_cci_pairs)) { + lr <- head(lr, as.integer(max_cci_pairs)) } lr } diff --git a/benchmarking/lr_2026_atera/runners/r/run_spatalk.R b/benchmarking/cci_2026_atera/runners/r/run_spatalk.R similarity index 92% rename from benchmarking/lr_2026_atera/runners/r/run_spatalk.R rename to benchmarking/cci_2026_atera/runners/r/run_spatalk.R index e59ac72..07a594d 100644 --- a/benchmarking/lr_2026_atera/runners/r/run_spatalk.R +++ b/benchmarking/cci_2026_atera/runners/r/run_spatalk.R @@ -1,7 +1,7 @@ args_all <- commandArgs(trailingOnly = FALSE) file_arg <- grep("^--file=", args_all, value = TRUE) script_dir <- if (length(file_arg) > 0) dirname(normalizePath(sub("^--file=", "", file_arg[[1]]))) else getwd() -source(file.path(script_dir, "run_r_lr_utils.R")) +source(file.path(script_dir, "run_r_cci_utils.R")) suppressPackageStartupMessages({ library(jsonlite) @@ -20,7 +20,7 @@ get_spatalk_data <- function(name) { stop(sprintf("SpaTalk object '%s' was not found.", name), call. = FALSE) } -opts <- parse_lr_args() +opts <- parse_cci_args() method <- "spatalk" output_dir <- opts[["output-dir"]] %||% stop("--output-dir is required", call. = FALSE) dir.create(output_dir, recursive = TRUE, showWarnings = FALSE) @@ -34,7 +34,7 @@ input_manifest <- opts[["input-manifest"]] %||% fail_run(output_dir, method, "-- database_mode <- opts[["database-mode"]] %||% "common" phase <- opts[["phase"]] %||% "smoke" n_cores <- as.integer(opts[["n-cores"]] %||% 8) -max_lr_pairs <- opts[["max-lr-pairs"]] +max_cci_pairs <- opts[["max-cci-pairs"]] max_cells <- opts[["max-cells"]] seed <- as.integer(opts[["seed"]] %||% 1) n_neighbor <- as.integer(opts[["n-neighbor"]] %||% 10) @@ -51,7 +51,7 @@ params <- list( input_manifest = input_manifest, output_dir = output_dir, n_cores = n_cores, - max_lr_pairs = max_lr_pairs, + max_cci_pairs = max_cci_pairs, max_cells = max_cells, seed = seed, n_neighbor = n_neighbor, @@ -67,9 +67,9 @@ tryCatch({ manifest <- jsonlite::fromJSON(input_manifest, simplifyVector = FALSE) bundle <- read_sparse_bundle(manifest, phase, max_cells = max_cells, seed = seed) counts <- bundle$counts - lr <- read_lr_database(manifest, database_mode, max_lr_pairs = max_lr_pairs) + lr <- read_cci_resource(manifest, database_mode, max_cci_pairs = max_cci_pairs) lr <- lr[lr$ligand %in% rownames(counts) & lr$receptor %in% rownames(counts), , drop = FALSE] - if (nrow(lr) == 0) stop("No common LR pairs were detectable in the sparse bundle.") + if (nrow(lr) == 0) stop("No common CCI pairs were detectable in the sparse bundle.") lrpairs <- data.frame(ligand = lr$ligand, receptor = lr$receptor, species = "Human", stringsAsFactors = FALSE) suppressPackageStartupMessages(library(SpaTalk)) @@ -108,7 +108,7 @@ tryCatch({ use_n_cores = n_cores ) raw <- as.data.frame(object@lrpair) - if (nrow(raw) == 0) stop("SpaTalk dec_cci_all returned no LR rows.") + if (nrow(raw) == 0) stop("SpaTalk dec_cci_all returned no CCI rows.") raw_path <- write_raw_tsv(raw, output_dir, method, "spatalk_dec_cci_all.tsv") saveRDS(object, file.path(output_dir, "raw", "spatalk_object.rds")) @@ -139,7 +139,7 @@ tryCatch({ phase = phase, raw_tsv = raw_path, standardized_tsv_gz = std_path, - n_lr_pairs = nrow(lr), + n_interaction_pairs = nrow(lr), n_rows = nrow(std), elapsed_seconds = as.numeric(difftime(Sys.time(), started, units = "secs")), package_versions = list( diff --git a/benchmarking/lr_2026_atera/runs/.gitkeep b/benchmarking/cci_2026_atera/runs/.gitkeep similarity index 100% rename from benchmarking/lr_2026_atera/runs/.gitkeep rename to benchmarking/cci_2026_atera/runs/.gitkeep diff --git a/benchmarking/lr_2026_atera/scripts/aggregate_results.py b/benchmarking/cci_2026_atera/scripts/aggregate_results.py similarity index 96% rename from benchmarking/lr_2026_atera/scripts/aggregate_results.py rename to benchmarking/cci_2026_atera/scripts/aggregate_results.py index 704a6d7..681e71b 100644 --- a/benchmarking/lr_2026_atera/scripts/aggregate_results.py +++ b/benchmarking/cci_2026_atera/scripts/aggregate_results.py @@ -14,7 +14,7 @@ def main() -> None: parser.add_argument("--output-path", default=None) args = parser.parse_args() - layout = resolve_layout(relative_root=args.benchmark_root or Path("benchmarking") / "lr_2026_atera") + layout = resolve_layout(relative_root=args.benchmark_root or Path("benchmarking") / "cci_2026_atera") result_paths = args.result_path or [str(path) for path in sorted(layout.runs_dir.glob("**/*standardized*.tsv"))] if not result_paths: raise SystemExit("No standardized result tables were found.") diff --git a/benchmarking/lr_2026_atera/scripts/collect_a100_results.py b/benchmarking/cci_2026_atera/scripts/collect_a100_results.py similarity index 97% rename from benchmarking/lr_2026_atera/scripts/collect_a100_results.py rename to benchmarking/cci_2026_atera/scripts/collect_a100_results.py index 8eae263..3fa3c8d 100644 --- a/benchmarking/lr_2026_atera/scripts/collect_a100_results.py +++ b/benchmarking/cci_2026_atera/scripts/collect_a100_results.py @@ -10,7 +10,7 @@ def main() -> None: parser = argparse.ArgumentParser(description="Generate or execute A100 result recovery commands.") parser.add_argument("--benchmark-root", default=None) - parser.add_argument("--remote-root", default="/data/taobo.hu/pyxenium_lr_benchmark_2026-04") + parser.add_argument("--remote-root", default="/data/taobo.hu/pyxenium_cci_benchmark_2026-04") parser.add_argument("--host", default=None) parser.add_argument("--user", default=None) parser.add_argument("--transfer-mode", default="auto", choices=["auto", "rsync", "scp"]) diff --git a/benchmarking/lr_2026_atera/scripts/create_env.py b/benchmarking/cci_2026_atera/scripts/create_env.py similarity index 98% rename from benchmarking/lr_2026_atera/scripts/create_env.py rename to benchmarking/cci_2026_atera/scripts/create_env.py index dc7bca0..92a46a6 100644 --- a/benchmarking/lr_2026_atera/scripts/create_env.py +++ b/benchmarking/cci_2026_atera/scripts/create_env.py @@ -49,7 +49,7 @@ def main() -> None: args = parser.parse_args() repo_root = _repo_root(Path.cwd()) - benchmark_root = repo_root / (args.benchmark_root or Path("benchmarking") / "lr_2026_atera") + benchmark_root = repo_root / (args.benchmark_root or Path("benchmarking") / "cci_2026_atera") methods_path = Path(args.methods_config) if args.methods_config else benchmark_root / "configs" / "methods.yaml" methods = yaml.safe_load(methods_path.read_text(encoding="utf-8")).get("methods", []) diff --git a/benchmarking/lr_2026_atera/scripts/finalize_a100_full_common.py b/benchmarking/cci_2026_atera/scripts/finalize_a100_full_common.py similarity index 97% rename from benchmarking/lr_2026_atera/scripts/finalize_a100_full_common.py rename to benchmarking/cci_2026_atera/scripts/finalize_a100_full_common.py index 15438d3..1b6378b 100644 --- a/benchmarking/lr_2026_atera/scripts/finalize_a100_full_common.py +++ b/benchmarking/cci_2026_atera/scripts/finalize_a100_full_common.py @@ -18,7 +18,7 @@ compute_pathway_relevance, compute_robustness, compute_spatial_coherence, - render_atera_lr_benchmark_report, + render_atera_cci_benchmark_report, resolve_layout, score_biological_performance, ) @@ -191,7 +191,7 @@ def write_commot_gating(layout) -> dict[str, Any]: full_cells = int(manifest.get("full_n_cells") or 170057) smoke_cells = int(manifest.get("smoke_n_cells") or 20000) full_pairs = int((manifest.get("common_db") or {}).get("n_pairs") or 3299) - smoke_pairs = int(smoke_params.get("lr_pairs") or smoke_params.get("max_lr_pairs") or 100) + smoke_pairs = int(smoke_params.get("max_cci_pairs") or 100) smoke_elapsed = float(smoke_summary.get("elapsed_seconds") or 0.0) estimate = smoke_elapsed * (full_cells / smoke_cells) * (full_pairs / smoke_pairs) if smoke_elapsed else math.nan payload = { @@ -201,9 +201,9 @@ def write_commot_gating(layout) -> dict[str, Any]: "phase": "full", "smoke_elapsed_seconds": smoke_elapsed, "smoke_cells": smoke_cells, - "smoke_lr_pairs": smoke_pairs, + "smoke_cci_pairs": smoke_pairs, "full_cells": full_cells, - "full_lr_pairs": full_pairs, + "full_cci_pairs": full_pairs, "linear_runtime_estimate_seconds": estimate, "linear_runtime_estimate_hours": estimate / 3600 if not math.isnan(estimate) else None, "resource_limit_hours": 6, @@ -219,8 +219,8 @@ def write_commot_gating(layout) -> dict[str, Any]: "# Method Card: COMMOT full common-db", "", "- Status: `appendix_gated`", - f"- Smoke benchmark: `{smoke_cells}` cells x `{smoke_pairs}` LR pairs in `{smoke_elapsed:.1f}` seconds.", - f"- Full target: `{full_cells}` cells x `{full_pairs}` LR pairs.", + f"- Smoke benchmark: `{smoke_cells}` cells x `{smoke_pairs}` CCI pairs in `{smoke_elapsed:.1f}` seconds.", + f"- Full target: `{full_cells}` cells x `{full_pairs}` CCI pairs.", f"- Linear lower-bound runtime estimate: `{payload['linear_runtime_estimate_hours']:.1f}` hours.", "- Decision: keep COMMOT in appendix unless a bounded full strategy is explicitly requested.", "- Reason: the estimate is far above the 6 hour promotion gate, and COMMOT communication tensors are expected to scale worse than this simple lower bound.", @@ -285,7 +285,7 @@ def write_tables(layout, *, combined: pd.DataFrame, run_status: pd.DataFrame) -> outputs[key].parent.mkdir(parents=True, exist_ok=True) table.to_csv(outputs[key], sep="\t", index=False) - markdown = render_atera_lr_benchmark_report( + markdown = render_atera_cci_benchmark_report( combined_results=combined, canonical_summary=canonical_summary, pathway_summary=pathway_summary, @@ -304,8 +304,8 @@ def write_tables(layout, *, combined: pd.DataFrame, run_status: pd.DataFrame) -> def main() -> None: - parser = argparse.ArgumentParser(description="Finalize collected A100 full common-db LR benchmark outputs.") - parser.add_argument("--benchmark-root", default="benchmarking/lr_2026_atera") + parser = argparse.ArgumentParser(description="Finalize collected A100 full common-db CCI benchmark outputs.") + parser.add_argument("--benchmark-root", default="benchmarking/cci_2026_atera") parser.add_argument("--cellchat-status", default="running", choices=["running", "failed", "pending"]) parser.add_argument("--output-json", default=None) args = parser.parse_args() diff --git a/benchmarking/lr_2026_atera/scripts/pdc/collect_pdc_results.py b/benchmarking/cci_2026_atera/scripts/pdc/collect_pdc_results.py similarity index 94% rename from benchmarking/lr_2026_atera/scripts/pdc/collect_pdc_results.py rename to benchmarking/cci_2026_atera/scripts/pdc/collect_pdc_results.py index 3580c59..377b946 100644 --- a/benchmarking/lr_2026_atera/scripts/pdc/collect_pdc_results.py +++ b/benchmarking/cci_2026_atera/scripts/pdc/collect_pdc_results.py @@ -10,7 +10,7 @@ DEFAULT_PDC_HOST = "pdc" -DEFAULT_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04" +DEFAULT_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04" REMOTE_DIRS = ("runs", "results", "logs", "reports", "data/source_cache/breast/source_manifest.json") @@ -87,10 +87,10 @@ def collect( def main() -> None: - parser = argparse.ArgumentParser(description="Collect PDC LR benchmark outputs to the local benchmark directory.") + parser = argparse.ArgumentParser(description="Collect PDC CCI benchmark outputs to the local benchmark directory.") parser.add_argument("--host", default=DEFAULT_PDC_HOST) parser.add_argument("--remote-root", default=DEFAULT_PDC_ROOT) - parser.add_argument("--benchmark-root", default="benchmarking/lr_2026_atera") + parser.add_argument("--benchmark-root", default="benchmarking/cci_2026_atera") parser.add_argument("--tag", default=None) parser.add_argument("--execute", action="store_true") parser.add_argument("--since-last", action="store_true") diff --git a/benchmarking/lr_2026_atera/scripts/pdc/monitor_pdc_jobs.py b/benchmarking/cci_2026_atera/scripts/pdc/monitor_pdc_jobs.py similarity index 95% rename from benchmarking/lr_2026_atera/scripts/pdc/monitor_pdc_jobs.py rename to benchmarking/cci_2026_atera/scripts/pdc/monitor_pdc_jobs.py index 29ba8d6..477132f 100644 --- a/benchmarking/lr_2026_atera/scripts/pdc/monitor_pdc_jobs.py +++ b/benchmarking/cci_2026_atera/scripts/pdc/monitor_pdc_jobs.py @@ -10,7 +10,7 @@ DEFAULT_PDC_HOST = "pdc" -DEFAULT_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04" +DEFAULT_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04" def q(value: str | Path) -> str: @@ -117,7 +117,7 @@ def parse_monitor_output(text: str) -> dict[str, Any]: def render_markdown(status: dict[str, Any], remote_root: str) -> str: lines = [ - "# PDC LR Benchmark Live Status", + "# PDC CCI Benchmark Live Status", "", f"- Updated: `{status['checked_at']}`", f"- Remote root: `{remote_root}`", @@ -145,7 +145,7 @@ def render_markdown(status: dict[str, Any], remote_root: str) -> str: def main() -> None: - parser = argparse.ArgumentParser(description="Monitor PDC LR benchmark Slurm jobs and remote run artifacts.") + parser = argparse.ArgumentParser(description="Monitor PDC CCI benchmark Slurm jobs and remote run artifacts.") parser.add_argument("--host", default=DEFAULT_PDC_HOST) parser.add_argument("--remote-root", default=DEFAULT_PDC_ROOT) parser.add_argument("--local-root", default=None) @@ -163,7 +163,7 @@ def main() -> None: "raw_stderr": raw["stderr"], **parsed, } - local_root = Path(args.local_root) if args.local_root else Path.cwd() / "benchmarking" / "lr_2026_atera" + local_root = Path(args.local_root) if args.local_root else Path.cwd() / "benchmarking" / "cci_2026_atera" output_json = Path(args.output_json) if args.output_json else local_root / "results" / "pdc_live_job_status.json" output_md = Path(args.output_md) if args.output_md else local_root / "reports" / "pdc_live_status.md" output_json.parent.mkdir(parents=True, exist_ok=True) diff --git a/benchmarking/lr_2026_atera/scripts/pdc/prepare_pdc_bundle.sh b/benchmarking/cci_2026_atera/scripts/pdc/prepare_pdc_bundle.sh similarity index 70% rename from benchmarking/lr_2026_atera/scripts/pdc/prepare_pdc_bundle.sh rename to benchmarking/cci_2026_atera/scripts/pdc/prepare_pdc_bundle.sh index 637929b..b2e4c13 100644 --- a/benchmarking/lr_2026_atera/scripts/pdc/prepare_pdc_bundle.sh +++ b/benchmarking/cci_2026_atera/scripts/pdc/prepare_pdc_bundle.sh @@ -1,14 +1,14 @@ #!/usr/bin/env bash set -euo pipefail -ROOT="${PDC_LR_ROOT:-/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04}" -SOURCE_ROOT="${PDC_LR_SOURCE_ROOT:-$ROOT/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs}" -PY_ENV="${PDC_LR_PREP_ENV:-$ROOT/envs/python/prep}" +ROOT="${PDC_CCI_ROOT:-/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04}" +SOURCE_ROOT="${PDC_CCI_SOURCE_ROOT:-$ROOT/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs}" +PY_ENV="${PDC_CCI_PREP_ENV:-$ROOT/envs/python/prep}" PYTHON_MODULE="${PDC_LR_PYTHON_MODULE:-python/3.12.3}" mkdir -p "$ROOT"/{data/full,data/smoke,logs,reports,results,runs,tmp,envs/python} mkdir -p "$ROOT/configs" -cp -f "$ROOT"/repo/benchmarking/lr_2026_atera/configs/* "$ROOT/configs/" 2>/dev/null || true +cp -f "$ROOT"/repo/benchmarking/cci_2026_atera/configs/* "$ROOT/configs/" 2>/dev/null || true export TMPDIR="$ROOT/tmp" export PYTHONPATH="$ROOT/repo/src:${PYTHONPATH:-}" @@ -27,15 +27,15 @@ python -m pip install --upgrade pip setuptools wheel python -m pip install -e "$ROOT/repo" python -m pip install pyarrow -python "$ROOT/repo/benchmarking/lr_2026_atera/scripts/prepare_data.py" \ +python "$ROOT/repo/benchmarking/cci_2026_atera/scripts/prepare_data.py" \ --dataset-root "$SOURCE_ROOT" \ --benchmark-root "$ROOT" \ --prefer h5 \ --skip-full-h5ad \ --output-json "$ROOT/logs/pdc_prepare_payload.json" -if [ -f "$ROOT/data/staged_common/lr_db_common.tsv" ]; then - cp -f "$ROOT/data/staged_common/lr_db_common.tsv" "$ROOT/data/lr_db_common.tsv" +if [ -f "$ROOT/data/staged_common/cci_resource_common.tsv" ]; then + cp -f "$ROOT/data/staged_common/cci_resource_common.tsv" "$ROOT/data/cci_resource_common.tsv" [ -f "$ROOT/data/staged_common/atera_smoke_panel.tsv" ] && cp -f "$ROOT/data/staged_common/atera_smoke_panel.tsv" "$ROOT/data/atera_smoke_panel.tsv" [ -f "$ROOT/data/staged_common/celltype_pairs.tsv" ] && cp -f "$ROOT/data/staged_common/celltype_pairs.tsv" "$ROOT/data/celltype_pairs.tsv" python - <<'PY' @@ -47,14 +47,14 @@ from pathlib import Path import pandas as pd -root = Path(os.environ.get("PDC_LR_ROOT", "/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04")) +root = Path(os.environ.get("PDC_CCI_ROOT", "/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04")) manifest_path = root / "data" / "input_manifest.json" manifest = json.loads(manifest_path.read_text(encoding="utf-8")) -lr_path = root / "data" / "lr_db_common.tsv" -manifest["lr_db_common_tsv"] = str(lr_path) -manifest["common_db"] = {"source": "staged_local_lr_db_common", "n_pairs": int(len(pd.read_csv(lr_path, sep="\t")))} +lr_path = root / "data" / "cci_resource_common.tsv" +manifest["cci_resource_common_tsv"] = str(lr_path) +manifest["common_db"] = {"source": "staged_local_cci_db_common", "n_pairs": int(len(pd.read_csv(lr_path, sep="\t")))} manifest_path.write_text(json.dumps(manifest, indent=2) + "\n", encoding="utf-8") -print(f"Patched PDC manifest to use staged common LR DB: {manifest['common_db']}") +print(f"Patched PDC manifest to use staged common CCI resource: {manifest['common_db']}") PY fi @@ -65,7 +65,7 @@ import json import os from pathlib import Path -root = Path(os.environ.get("PDC_LR_ROOT", "/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04")) +root = Path(os.environ.get("PDC_CCI_ROOT", "/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04")) manifest = root / "data" / "input_manifest.json" payload = json.loads(manifest.read_text(encoding="utf-8")) full_bundle = payload.get("full_bundle") or {} diff --git a/benchmarking/lr_2026_atera/scripts/pdc/stage_to_pdc.py b/benchmarking/cci_2026_atera/scripts/pdc/stage_to_pdc.py similarity index 92% rename from benchmarking/lr_2026_atera/scripts/pdc/stage_to_pdc.py rename to benchmarking/cci_2026_atera/scripts/pdc/stage_to_pdc.py index 5d8446a..c2b78a8 100644 --- a/benchmarking/lr_2026_atera/scripts/pdc/stage_to_pdc.py +++ b/benchmarking/cci_2026_atera/scripts/pdc/stage_to_pdc.py @@ -14,7 +14,7 @@ DEFAULT_PDC_HOST = "pdc" -DEFAULT_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04" +DEFAULT_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04" DEFAULT_LOCAL_XENIUM_ROOT = Path( r"Y:\long\10X_datasets\Xenium\Atera\WTA_Preview_FFPE_Breast_Cancer_outs" ) @@ -31,22 +31,21 @@ "README.md", "LICENSE", "src", - "benchmarking/lr_2026_atera/configs", - "benchmarking/lr_2026_atera/envs", - "benchmarking/lr_2026_atera/runners", - "benchmarking/lr_2026_atera/scripts", + "benchmarking/cci_2026_atera/configs", + "benchmarking/cci_2026_atera/envs", + "benchmarking/cci_2026_atera/runners", + "benchmarking/cci_2026_atera/scripts", ) SMOKE_ITEMS = ( - "benchmarking/lr_2026_atera/data/input_manifest.json", - "benchmarking/lr_2026_atera/data/lr_db_common.tsv", - "benchmarking/lr_2026_atera/data/atera_smoke_panel.tsv", - "benchmarking/lr_2026_atera/data/celltype_pairs.tsv", - "benchmarking/lr_2026_atera/data/smoke", + "benchmarking/cci_2026_atera/data/cci_resource_common.tsv", + "benchmarking/cci_2026_atera/data/atera_smoke_panel.tsv", + "benchmarking/cci_2026_atera/data/celltype_pairs.tsv", + "benchmarking/cci_2026_atera/data/smoke", ) PANEL_ITEMS = ( - "benchmarking/lr_2026_atera/data/lr_db_common.tsv", - "benchmarking/lr_2026_atera/data/atera_smoke_panel.tsv", - "benchmarking/lr_2026_atera/data/celltype_pairs.tsv", + "benchmarking/cci_2026_atera/data/cci_resource_common.tsv", + "benchmarking/cci_2026_atera/data/atera_smoke_panel.tsv", + "benchmarking/cci_2026_atera/data/celltype_pairs.tsv", ) @@ -144,7 +143,7 @@ def create_archive(repo_root: Path, archive_path: Path, *, include_smoke: bool) for item in PANEL_ITEMS: source = repo_root / item if source.exists(): - rel = Path(item).relative_to("benchmarking/lr_2026_atera/data") + rel = Path(item).relative_to("benchmarking/cci_2026_atera/data") arcname = str(Path("data") / "staged_common" / rel).replace(os.sep, "/") add_path_to_archive(tar, source, arcname) entries.append({"local": str(source), "archive": arcname, "kind": "common_panel"}) @@ -152,7 +151,7 @@ def create_archive(repo_root: Path, archive_path: Path, *, include_smoke: bool) for item in SMOKE_ITEMS: source = repo_root / item if source.exists(): - rel = Path(item).relative_to("benchmarking/lr_2026_atera/data") + rel = Path(item).relative_to("benchmarking/cci_2026_atera/data") arcname = str(Path("data") / rel).replace(os.sep, "/") add_path_to_archive(tar, source, arcname) entries.append({"local": str(source), "archive": arcname, "kind": "smoke_data"}) @@ -172,7 +171,7 @@ def build_stage_plan( ) -> dict[str, Any]: remote_root = remote_root.rstrip("/") remote_cache = f"{remote_root}/{SOURCE_CACHE_REL}" - archive_path = archive_path or repo_root / "benchmarking" / "lr_2026_atera" / "logs" / "pdc_stage_payload.tar.gz" + archive_path = archive_path or repo_root / "benchmarking" / "cci_2026_atera" / "logs" / "pdc_stage_payload.tar.gz" raw_items = [] for name in REQUIRED_RAW_FILES: local_path = local_xenium_root / name @@ -320,7 +319,7 @@ def execute_stage_plan(plan: dict[str, Any], *, plan_only: bool = False) -> dict def main() -> None: - parser = argparse.ArgumentParser(description="Stage pyXenium LR benchmark code and breast source cache to PDC.") + parser = argparse.ArgumentParser(description="Stage pyXenium CCI benchmark code and breast source cache to PDC.") parser.add_argument("--host", default=DEFAULT_PDC_HOST) parser.add_argument("--remote-root", default=DEFAULT_PDC_ROOT) parser.add_argument("--local-xenium-root", default=str(DEFAULT_LOCAL_XENIUM_ROOT)) diff --git a/benchmarking/lr_2026_atera/scripts/pdc/submit_pdc_matrix.py b/benchmarking/cci_2026_atera/scripts/pdc/submit_pdc_matrix.py similarity index 97% rename from benchmarking/lr_2026_atera/scripts/pdc/submit_pdc_matrix.py rename to benchmarking/cci_2026_atera/scripts/pdc/submit_pdc_matrix.py index 779a9c0..16b1653 100644 --- a/benchmarking/lr_2026_atera/scripts/pdc/submit_pdc_matrix.py +++ b/benchmarking/cci_2026_atera/scripts/pdc/submit_pdc_matrix.py @@ -13,7 +13,7 @@ DEFAULT_PDC_HOST = "pdc" -DEFAULT_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04" +DEFAULT_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04" DEFAULT_ACCOUNT = "naiss2026-4-680" ALL_METHODS = ( "pyxenium", @@ -269,7 +269,7 @@ def method_run_command(method: str, cfg: MethodConfig, root: str, stage: str) -> mkdir -p "$OUT" trap 'rc=$?; mkdir -p "$OUT"; printf "# {method} PDC method card\\n\\n- Status: failed\\n- Stage: {stage}\\n- Exit code: %s\\n- PDC note: {cfg.pdc_note}\\n" "$rc" > "$OUT/method_card.md"; exit "$rc"' ERR {activate_for_method(method, cfg, root)} -python "$ROOT/repo/benchmarking/lr_2026_atera/scripts/run_method.py" \ +python "$ROOT/repo/benchmarking/cci_2026_atera/scripts/run_method.py" \ --method {q(method)} \ --input-manifest "$ROOT/data/input_manifest.json" \ --benchmark-root "$ROOT" \ @@ -282,7 +282,7 @@ def method_run_command(method: str, cfg: MethodConfig, root: str, stage: str) -> def prepare_command(root: str) -> str: - return f"bash {q(root)}/repo/benchmarking/lr_2026_atera/scripts/pdc/prepare_pdc_bundle.sh" + return f"bash {q(root)}/repo/benchmarking/cci_2026_atera/scripts/pdc/prepare_pdc_bundle.sh" def job_script( @@ -315,7 +315,7 @@ def job_script( export MKL_NUM_THREADS={cpus} mkdir -p "$ROOT"/{{logs,runs,results,reports,tmp,slurm,envs/python,envs/r_libs}} mkdir -p "$ROOT/configs" -cp -f "$ROOT"/repo/benchmarking/lr_2026_atera/configs/* "$ROOT/configs/" 2>/dev/null || true +cp -f "$ROOT"/repo/benchmarking/cci_2026_atera/configs/* "$ROOT/configs/" 2>/dev/null || true cd "$ROOT/repo" /usr/bin/time -v bash -lc {q(body)} 2> >(tee -a "$ROOT/logs/{job_id}.resource.log" >&2) """ @@ -465,7 +465,7 @@ def submit_jobs(host: str, root: str, jobs: list[dict[str, Any]]) -> list[dict[s def main() -> None: - parser = argparse.ArgumentParser(description="Generate and submit a PDC Slurm matrix for LR benchmarking.") + parser = argparse.ArgumentParser(description="Generate and submit a PDC Slurm matrix for CCI benchmarking.") parser.add_argument("--host", default=DEFAULT_PDC_HOST) parser.add_argument("--remote-root", default=DEFAULT_PDC_ROOT) parser.add_argument("--account", default=DEFAULT_ACCOUNT) diff --git a/benchmarking/lr_2026_atera/scripts/prepare_a100_bundle.py b/benchmarking/cci_2026_atera/scripts/prepare_a100_bundle.py similarity index 93% rename from benchmarking/lr_2026_atera/scripts/prepare_a100_bundle.py rename to benchmarking/cci_2026_atera/scripts/prepare_a100_bundle.py index 81b3f1e..fe67b0e 100644 --- a/benchmarking/lr_2026_atera/scripts/prepare_a100_bundle.py +++ b/benchmarking/cci_2026_atera/scripts/prepare_a100_bundle.py @@ -7,14 +7,14 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Build an A100 stage plan and LR full-run job manifest.") + parser = argparse.ArgumentParser(description="Build an A100 stage plan and CCI full-run job manifest.") parser.add_argument("--benchmark-root", default=None) parser.add_argument("--remote-root", default=DEFAULT_A100_REMOTE_ROOT) parser.add_argument("--remote-xenium-root", default=DEFAULT_A100_READONLY_XENIUM_ROOT) parser.add_argument("--methods", default="pyxenium,squidpy,liana,commot,cellchat") parser.add_argument("--database-mode", default="common-db") parser.add_argument("--phase", choices=["smoke", "full"], default="full") - parser.add_argument("--max-lr-pairs", type=int, default=None) + parser.add_argument("--max-cci-pairs", type=int, default=None) parser.add_argument("--n-perms", type=int, default=100) parser.add_argument("--skip-prepare", action="store_true") parser.add_argument("--stage-data", action="store_true", default=None) @@ -35,7 +35,7 @@ def main() -> None: methods=[item.strip() for item in args.methods.split(",") if item.strip()], database_mode=args.database_mode, phase=args.phase, - max_lr_pairs=args.max_lr_pairs, + max_cci_pairs=args.max_cci_pairs, n_perms=args.n_perms, require_full=not args.allow_missing_full, include_prepare=not args.skip_prepare, diff --git a/benchmarking/lr_2026_atera/scripts/prepare_data.py b/benchmarking/cci_2026_atera/scripts/prepare_data.py similarity index 90% rename from benchmarking/lr_2026_atera/scripts/prepare_data.py rename to benchmarking/cci_2026_atera/scripts/prepare_data.py index 367e476..c4edbf8 100644 --- a/benchmarking/lr_2026_atera/scripts/prepare_data.py +++ b/benchmarking/cci_2026_atera/scripts/prepare_data.py @@ -4,11 +4,11 @@ import json from pathlib import Path -from pyXenium.benchmarking import prepare_atera_lr_benchmark +from pyXenium.benchmarking import prepare_atera_cci_benchmark def main() -> None: - parser = argparse.ArgumentParser(description="Prepare the Atera Xenium LR benchmark input bundle.") + parser = argparse.ArgumentParser(description="Prepare the Atera Xenium CCI benchmark input bundle.") parser.add_argument("--dataset-root", "--xenium-root", dest="dataset_root", default=None) parser.add_argument("--benchmark-root", default=None) parser.add_argument("--tbc-results", default=None) @@ -20,7 +20,7 @@ def main() -> None: parser.add_argument("--output-json", default=None) args = parser.parse_args() - payload = prepare_atera_lr_benchmark( + payload = prepare_atera_cci_benchmark( dataset_root=args.dataset_root, benchmark_root=args.benchmark_root, tbc_results=args.tbc_results, diff --git a/benchmarking/lr_2026_atera/scripts/render_report.py b/benchmarking/cci_2026_atera/scripts/render_report.py similarity index 96% rename from benchmarking/lr_2026_atera/scripts/render_report.py rename to benchmarking/cci_2026_atera/scripts/render_report.py index c6c2653..2b8de38 100644 --- a/benchmarking/lr_2026_atera/scripts/render_report.py +++ b/benchmarking/cci_2026_atera/scripts/render_report.py @@ -14,7 +14,7 @@ compute_robustness, build_a100_resource_summary, build_engineering_summary, - render_atera_lr_benchmark_report, + render_atera_cci_benchmark_report, resolve_layout, score_biological_performance, summarize_run_status, @@ -30,7 +30,7 @@ def main() -> None: parser.add_argument("--output-path", default=None) args = parser.parse_args() - layout = resolve_layout(relative_root=args.benchmark_root or Path("benchmarking") / "lr_2026_atera") + layout = resolve_layout(relative_root=args.benchmark_root or Path("benchmarking") / "cci_2026_atera") combined_path = Path(args.combined_results) if args.combined_results else layout.results_dir / "combined_standardized.tsv" canonical_path = Path(args.canonical_config) if args.canonical_config else layout.config_dir / "canonical_axes.yaml" pathway_path = Path(args.pathway_config) if args.pathway_config else layout.config_dir / "pathways.yaml" @@ -56,7 +56,7 @@ def main() -> None: robustness_summary=robustness_summary, novelty_summary=novelty_summary, ) - markdown = render_atera_lr_benchmark_report( + markdown = render_atera_cci_benchmark_report( combined_results=combined, canonical_summary=canonical_summary, pathway_summary=pathway_summary, diff --git a/benchmarking/lr_2026_atera/scripts/run_a100_plan.py b/benchmarking/cci_2026_atera/scripts/run_a100_plan.py similarity index 95% rename from benchmarking/lr_2026_atera/scripts/run_a100_plan.py rename to benchmarking/cci_2026_atera/scripts/run_a100_plan.py index 213aa8b..8db76bf 100644 --- a/benchmarking/lr_2026_atera/scripts/run_a100_plan.py +++ b/benchmarking/cci_2026_atera/scripts/run_a100_plan.py @@ -7,7 +7,7 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Dry-run or execute an A100 LR benchmark job manifest.") + parser = argparse.ArgumentParser(description="Dry-run or execute an A100 CCI benchmark job manifest.") parser.add_argument("--plan-json", required=True) parser.add_argument("--job-id", action="append", default=[]) parser.add_argument("--execute", action="store_true") diff --git a/benchmarking/lr_2026_atera/scripts/run_method.py b/benchmarking/cci_2026_atera/scripts/run_method.py similarity index 92% rename from benchmarking/lr_2026_atera/scripts/run_method.py rename to benchmarking/cci_2026_atera/scripts/run_method.py index fb47232..b6fe5f8 100644 --- a/benchmarking/lr_2026_atera/scripts/run_method.py +++ b/benchmarking/cci_2026_atera/scripts/run_method.py @@ -8,14 +8,14 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Run or dry-run one Atera LR benchmark method adapter.") + parser = argparse.ArgumentParser(description="Run or dry-run one Atera CCI benchmark method adapter.") parser.add_argument("--method", required=True) parser.add_argument("--input-manifest", default=None) parser.add_argument("--output-dir", default=None) parser.add_argument("--benchmark-root", default=None) parser.add_argument("--database-mode", default="common-db") parser.add_argument("--phase", choices=["smoke", "full"], default="smoke") - parser.add_argument("--max-lr-pairs", type=int, default=None) + parser.add_argument("--max-cci-pairs", type=int, default=None) parser.add_argument("--n-perms", type=int, default=100) parser.add_argument("--chunk-id", type=int, default=None) parser.add_argument("--num-chunks", type=int, default=None) @@ -34,7 +34,7 @@ def main() -> None: "benchmark_root": args.benchmark_root, "database_mode": args.database_mode, "phase": args.phase, - "max_lr_pairs": args.max_lr_pairs, + "max_cci_pairs": args.max_cci_pairs, "n_perms": args.n_perms, "chunk_id": args.chunk_id, "num_chunks": args.num_chunks, diff --git a/benchmarking/lr_2026_atera/scripts/run_pyxenium_smoke.py b/benchmarking/cci_2026_atera/scripts/run_pyxenium_smoke.py similarity index 88% rename from benchmarking/lr_2026_atera/scripts/run_pyxenium_smoke.py rename to benchmarking/cci_2026_atera/scripts/run_pyxenium_smoke.py index 3b4a800..ae2ef69 100644 --- a/benchmarking/lr_2026_atera/scripts/run_pyxenium_smoke.py +++ b/benchmarking/cci_2026_atera/scripts/run_pyxenium_smoke.py @@ -13,18 +13,18 @@ def main() -> None: parser.add_argument("--input-h5ad", default=None) parser.add_argument("--output-dir", default=None) parser.add_argument("--tbc-results", default=None) - parser.add_argument("--lr-panel-path", default=None) + parser.add_argument("--cci-panel-path", default=None) parser.add_argument("--database-mode", default="smoke-panel") parser.add_argument("--export-figures", action="store_true") parser.add_argument("--output-json", default=None) args = parser.parse_args() - layout = resolve_layout(relative_root=args.benchmark_root or Path("benchmarking") / "lr_2026_atera") + layout = resolve_layout(relative_root=args.benchmark_root or Path("benchmarking") / "cci_2026_atera") payload = run_pyxenium_smoke( input_h5ad=args.input_h5ad or layout.data_dir / "smoke" / "adata_smoke.h5ad", output_dir=args.output_dir or layout.runs_dir / "pyxenium_smoke", tbc_results=args.tbc_results or Path(r"Y:\long\10X_datasets\Xenium\Atera\WTA_Preview_FFPE_Breast_Cancer_outs") / "sfplot_tbc_formal_wta" / "results", - lr_panel_path=args.lr_panel_path or layout.data_dir / "atera_smoke_panel.tsv", + cci_panel_path=args.cci_panel_path or layout.data_dir / "atera_smoke_panel.tsv", database_mode=args.database_mode, export_figures=args.export_figures, ) diff --git a/benchmarking/lr_2026_atera/scripts/smoke_core.py b/benchmarking/cci_2026_atera/scripts/smoke_core.py similarity index 87% rename from benchmarking/lr_2026_atera/scripts/smoke_core.py rename to benchmarking/cci_2026_atera/scripts/smoke_core.py index 8df29cb..10c3306 100644 --- a/benchmarking/lr_2026_atera/scripts/smoke_core.py +++ b/benchmarking/cci_2026_atera/scripts/smoke_core.py @@ -7,12 +7,12 @@ def main() -> None: - parser = argparse.ArgumentParser(description="Run or dry-run the first-wave Atera LR core smoke benchmark.") + parser = argparse.ArgumentParser(description="Run or dry-run the first-wave Atera CCI core smoke benchmark.") parser.add_argument("--methods", default="pyxenium,squidpy,liana,commot,cellchat") parser.add_argument("--input-manifest", default=None) parser.add_argument("--benchmark-root", default=None) parser.add_argument("--database-mode", default="common-db") - parser.add_argument("--max-lr-pairs", type=int, default=None) + parser.add_argument("--max-cci-pairs", type=int, default=None) parser.add_argument("--n-perms", type=int, default=100) parser.add_argument("--dry-run", action="store_true") parser.add_argument("--strict", action="store_true") @@ -23,7 +23,7 @@ def main() -> None: input_manifest=args.input_manifest, benchmark_root=args.benchmark_root, database_mode=args.database_mode, - max_lr_pairs=args.max_lr_pairs, + max_cci_pairs=args.max_cci_pairs, n_perms=args.n_perms, dry_run=args.dry_run, continue_on_error=not args.strict, diff --git a/benchmarking/lr_2026_atera/scripts/stage_to_a100.py b/benchmarking/cci_2026_atera/scripts/stage_to_a100.py similarity index 100% rename from benchmarking/lr_2026_atera/scripts/stage_to_a100.py rename to benchmarking/cci_2026_atera/scripts/stage_to_a100.py diff --git a/benchmarking/gmi_pdc/README.md b/benchmarking/gmi_pdc/README.md index 07055c4..89f9817 100644 --- a/benchmarking/gmi_pdc/README.md +++ b/benchmarking/gmi_pdc/README.md @@ -2,13 +2,13 @@ This scaffold runs the canonical contour-GMI Atera S1-vs-S5 validation on PDC Dardel with Slurm. It reuses the Xenium source cache already being copied for -the LR benchmark and writes all GMI-specific artifacts to a separate scratch +the CCI benchmark and writes all GMI-specific artifacts to a separate scratch root. Default dataset: ```text -/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs +/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs ``` Default GMI root: @@ -23,7 +23,7 @@ From the staged repo on Dardel: ```bash export PDC_ROOT=/cfs/klemming/scratch/h/hutaobo/pyxenium_gmi_contour_2026-04 -export PDC_XENIUM_ROOT=/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs +export PDC_XENIUM_ROOT=/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs bash benchmarking/gmi_pdc/scripts/bootstrap_pdc_env.sh bash benchmarking/gmi_pdc/scripts/prepare_pdc_inputs.sh diff --git a/docs/api/cci.md b/docs/api/cci.md new file mode 100644 index 0000000..bb32c7a --- /dev/null +++ b/docs/api/cci.md @@ -0,0 +1,11 @@ +# `pyXenium.cci` + +```{eval-rst} +.. currentmodule:: pyXenium.cci + +.. autosummary:: + :toctree: generated + :nosignatures: + + cci_topology_analysis +``` diff --git a/docs/api/index.md b/docs/api/index.md index 7efdd77..f470792 100644 --- a/docs/api/index.md +++ b/docs/api/index.md @@ -6,7 +6,7 @@ io multimodal -ligand_receptor +cci pathway contour gmi @@ -31,10 +31,10 @@ Xenium artifact readers, SData helpers, and compat export utilities. Canonical RNA + protein preparation, analysis, immune-resistance scoring, and workflows. ::: -:::{grid-item-card} pyXenium.ligand_receptor -:link: ligand_receptor +:::{grid-item-card} pyXenium.cci +:link: cci :link-type: doc -Topology-native ligand-receptor analysis. +Topology-native cell-cell interaction analysis. ::: :::{grid-item-card} pyXenium.pathway diff --git a/docs/api/ligand_receptor.md b/docs/api/ligand_receptor.md deleted file mode 100644 index 441dbe6..0000000 --- a/docs/api/ligand_receptor.md +++ /dev/null @@ -1,11 +0,0 @@ -# `pyXenium.ligand_receptor` - -```{eval-rst} -.. currentmodule:: pyXenium.ligand_receptor - -.. autosummary:: - :toctree: generated - :nosignatures: - - ligand_receptor_topology_analysis -``` diff --git a/docs/guides/gmi-contour.md b/docs/guides/gmi-contour.md index c9b84ad..c387545 100644 --- a/docs/guides/gmi-contour.md +++ b/docs/guides/gmi-contour.md @@ -32,7 +32,7 @@ GMI receives one combined design matrix: transformed to contour-level logCPM. - Spatial features are numeric contour descriptors from `build_contour_feature_table(...)`, including geometry, composition, context, - rim, gradient, edge-contrast, and ligand-receptor summaries when available. + rim, gradient, edge-contrast, and cell-cell interaction summaries when available. - `feature_metadata.tsv` records `feature_block = rna|spatial` for every design-matrix column. diff --git a/docs/index.md b/docs/index.md index cb0e886..1b683f8 100644 --- a/docs/index.md +++ b/docs/index.md @@ -16,7 +16,7 @@ changelog

Xenium I/O, multimodal analysis, topology workflows, contour-native spatial profiling, GMI inference, mechanostress analysis, and AI-driven spatial pathology handoff.

pyXenium is a Python toolkit for 10x Genomics Xenium with eight feature areas: - canonical Xenium I/O, multimodal RNA + protein analysis, topology-native ligand-receptor + canonical Xenium I/O, multimodal RNA + protein analysis, topology-native cell-cell interaction and pathway methods, contour-aware geometry workflows, contour-level GMI modeling, morphology-derived mechanostress analysis, and an optional handoff to the external AI-Driven Spatial Pathologist workflow through spatho. @@ -110,7 +110,7 @@ Call the external `spatho` workflow on Xenium cases structured by pyXenium `Xeni :::{grid-item-card} API :link: api/index :link-type: doc -Browse curated autosummary pages for `io`, `multimodal`, `ligand_receptor`, `pathway`, `contour`, `gmi`, and `mechanostress`. +Browse curated autosummary pages for `io`, `multimodal`, `cci`, `pathway`, `contour`, `gmi`, and `mechanostress`. ::: :::{grid-item-card} Changelog @@ -124,7 +124,7 @@ Track documentation, branding, and package-level changes. - `pyXenium.io`: Xenium artifact loading, partial export recovery, SData I/O, and SpatialData-compatible export. - `pyXenium.multimodal`: canonical RNA + protein loading, immune-resistance scoring, joint analyses, and packaged multimodal workflows. -- `pyXenium.ligand_receptor`: topology-native ligand-receptor analysis primitives. +- `pyXenium.cci`: topology-native cell-cell interaction analysis primitives. - `pyXenium.pathway`: pathway topology analysis and pathway activity scoring. - `pyXenium.contour`: GeoJSON contour import and contour-aware density profiling around polygon annotations. - `pyXenium.gmi`: contour-level GMI modeling for sparse main-effect and interaction discovery in spatial transcriptomics. diff --git a/docs/tutorials/ligand_receptor.ipynb b/docs/tutorials/cci.ipynb similarity index 99% rename from docs/tutorials/ligand_receptor.ipynb rename to docs/tutorials/cci.ipynb index a32a4d5..44f9304 100644 --- a/docs/tutorials/ligand_receptor.ipynb +++ b/docs/tutorials/cci.ipynb @@ -5,15 +5,15 @@ "id": "11d63fde", "metadata": {}, "source": [ - "# pyXenium.ligand_receptor Tutorial\n", + "# pyXenium.cci Tutorial\n", "\n", "## Overview\n", "\n", - "This notebook walks through the Atera WTA breast topology reproducibility bundle and focuses on how `pyXenium.ligand_receptor` turns precomputed topology anchors plus cell-type expression support into interpretable sender-receiver hypotheses.\n", + "This notebook walks through the Atera WTA breast topology reproducibility bundle and focuses on how `pyXenium.cci` turns precomputed topology anchors plus cell-type expression support into interpretable sender-receiver hypotheses.\n", "\n", "## Biological question\n", "\n", - "Which cell populations appear to drive the strongest ligand-receptor communication programs across tumor, stromal, immune, and vascular compartments in the Atera breast sample?\n" + "Which cell populations appear to drive the strongest cell-cell interaction communication programs across tumor, stromal, immune, and vascular compartments in the Atera breast sample?\n" ] }, { @@ -109,7 +109,7 @@ "\n", "- Raw study: Atera WTA FFPE breast Xenium export with precomputed `t_and_c` and `StructureMap` anchors.\n", "- Versioned outputs in this repository: `manuscript/atera_wta_breast_topology/`.\n", - "- Canonical API: `ligand_receptor_topology_analysis` and the packaged `run_atera_wta_breast_topology(...)` workflow.\n", + "- Canonical API: `cci_topology_analysis` and the packaged `run_atera_wta_breast_topology(...)` workflow.\n", "\n", "## Setup\n", "\n", @@ -154,7 +154,7 @@ " receptor\n", " sender_celltype\n", " receiver_celltype\n", - " LR_score\n", + " CCI_score\n", " local_contact\n", " \n", " \n", @@ -209,14 +209,14 @@ "" ], "text/plain": [ - " ligand receptor sender_celltype \\\n", + " cell-cell interaction sender_celltype \\\n", "0 CSF1 CSF1R CAFs, DCIS Associated \n", "1 CXCL12 CXCR4 CAFs, DCIS Associated \n", "2 DLL4 NOTCH3 Endothelial Cells \n", "3 JAG1 NOTCH1 11q13 Invasive Tumor Cells \n", "4 TGFB1 TGFBR2 Endothelial Cells \n", "\n", - " receiver_celltype LR_score local_contact \n", + " receiver_celltype CCI_score local_contact \n", "0 Macrophages 0.507387 0.044743 \n", "1 T Lymphocytes 0.633882 0.168430 \n", "2 Pericytes 0.662811 0.135465 \n", @@ -293,7 +293,7 @@ "" ], "text/plain": [ - " check ligand receptor \\\n", + " check cell-cell interaction \\\n", "0 CSF1-CSF1R top sender should not be Mast Cells CSF1 CSF1R \n", "1 CXCL12-CXCR4 should keep CAFs, DCIS Associated... CXCL12 CXCR4 \n", "2 DLL4-NOTCH3 top hit should be Endothelial Cell... DLL4 NOTCH3 \n", @@ -310,18 +310,18 @@ ], "source": [ "payload = json.loads((ARTIFACT_DIR / \"summary.json\").read_text(encoding=\"utf-8\"))\n", - "scores = pd.read_csv(ARTIFACT_DIR / \"lr_sender_receiver_scores.csv\")\n", + "scores = pd.read_csv(ARTIFACT_DIR / \"cci_sender_receiver_scores.csv\")\n", "\n", "top_pairs = (\n", - " scores.sort_values(\"LR_score\", ascending=False)\n", + " scores.sort_values(\"CCI_score\", ascending=False)\n", " .groupby([\"ligand\", \"receptor\"], as_index=False)\n", " .first()\n", - " [[\"ligand\", \"receptor\", \"sender_celltype\", \"receiver_celltype\", \"LR_score\", \"local_contact\"]]\n", + " [[\"ligand\", \"receptor\", \"sender_celltype\", \"receiver_celltype\", \"CCI_score\", \"local_contact\"]]\n", " .head(10)\n", ")\n", "\n", "display(top_pairs)\n", - "display(pd.DataFrame(payload[\"lr_acceptance\"]))\n" + "display(pd.DataFrame(payload[\"cci_acceptance\"]))\n" ] }, { @@ -331,7 +331,7 @@ "source": [ "## Core workflow\n", "\n", - "A standard rerun goes through the packaged validation entrypoint so that the same ligand-receptor panel and topology anchors are used each time.\n", + "A standard rerun goes through the packaged validation entrypoint so that the same cell-cell interaction panel and topology anchors are used each time.\n", "\n", "```python\n", "from pyXenium.validation import run_atera_wta_breast_topology\n", @@ -339,7 +339,7 @@ "study = run_atera_wta_breast_topology(\n", " dataset_root=str(ATERA_DATASET_PATH),\n", " tbc_results=str(TBC_RESULTS_PATH),\n", - " output_dir=\"./atera_lr_outputs\",\n", + " output_dir=\"./atera_cci_outputs\",\n", " export_figures=True,\n", ")\n", "```\n", @@ -363,7 +363,7 @@ { "data": { "text/markdown": [ - "Set `RUN_FULL_ANALYSIS = True` to recompute the Atera ligand-receptor bundle from the local Xenium export." + "Set `RUN_FULL_ANALYSIS = True` to recompute the Atera cell-cell interaction bundle from the local Xenium export." ], "text/plain": [ "" @@ -383,9 +383,9 @@ " output_dir=str(ARTIFACT_DIR),\n", " export_figures=True,\n", " )\n", - " display(pd.DataFrame(study[\"payload\"][\"lr_pair_summaries\"]))\n", + " display(pd.DataFrame(study[\"payload\"][\"cci_pair_summaries\"]))\n", "else:\n", - " display(Markdown(\"Set `RUN_FULL_ANALYSIS = True` to recompute the Atera ligand-receptor bundle from the local Xenium export.\"))\n" + " display(Markdown(\"Set `RUN_FULL_ANALYSIS = True` to recompute the Atera cell-cell interaction bundle from the local Xenium export.\"))\n" ] }, { @@ -433,8 +433,8 @@ } ], "source": [ - "display(Image(filename=str(ARTIFACT_DIR / \"figures\" / \"lr_summary_heatmap.png\")))\n", - "display(Image(filename=str(ARTIFACT_DIR / \"figures\" / \"lr_hotspot_overlay.png\")))\n" + "display(Image(filename=str(ARTIFACT_DIR / \"figures\" / \"cci_summary_heatmap.png\")))\n", + "display(Image(filename=str(ARTIFACT_DIR / \"figures\" / \"cci_hotspot_overlay.png\")))\n" ] }, { @@ -449,14 +449,14 @@ "## Caveats\n", "\n", "- The score is a composite; a strong hit can be driven by anchor quality, expression support, and local contact in different proportions.\n", - "- This notebook uses the fixed smoke-panel pairs from the Atera reproducibility workflow, not a whole-database ligand-receptor scan.\n", + "- This notebook uses the fixed smoke-panel pairs from the Atera reproducibility workflow, not a whole-database cell-cell interaction scan.\n", "- Precomputed topology anchors should be interpreted as study-specific spatial priors, not universal cell-type distances.\n", "\n", "## Next steps\n", "\n", "- Open the `pathway` notebook to compare communication programs with pathway-level topology on the same Atera sample.\n", - "- Inspect `lr_component_diagnostics.csv` when you need to understand why a pair ranked highly.\n", - "- Swap in a custom `lr_pairs` table if you want to test a focused biological hypothesis beyond the default smoke panel.\n" + "- Inspect `cci_component_diagnostics.csv` when you need to understand why a pair ranked highly.\n", + "- Swap in a custom `interaction_pairs` table if you want to test a focused biological hypothesis beyond the default smoke panel.\n" ] } ], diff --git a/docs/tutorials/ligand_receptor_benchmarking.md b/docs/tutorials/cci_benchmarking.md similarity index 88% rename from docs/tutorials/ligand_receptor_benchmarking.md rename to docs/tutorials/cci_benchmarking.md index 18dae07..917a4dc 100644 --- a/docs/tutorials/ligand_receptor_benchmarking.md +++ b/docs/tutorials/cci_benchmarking.md @@ -1,15 +1,15 @@ -# Whole-dataset LR benchmarking +# Whole-dataset CCI benchmarking ## Overview -This tutorial summarizes whole-dataset ligand-receptor benchmarking on the full +This tutorial summarizes whole-dataset cell-cell interaction benchmarking on the full Atera Xenium WTA breast sample (`170,057` cells). The clean PDC `full_common` -runs used a shared human ligand-receptor resource so that methods are compared +runs used a shared human cell-cell interaction resource so that methods are compared by recovered biology and method-internal rank behavior, not by raw score magnitude. -The benchmark is separate from the basic ligand-receptor tutorial, which focuses -on the fixed smoke/topology panel and the `pyXenium.ligand_receptor` workflow. +The benchmark is separate from the basic cell-cell interaction tutorial, which focuses +on the fixed smoke/topology panel and the `pyXenium.cci` workflow. ## Completed full common-db methods @@ -52,9 +52,9 @@ the `Unassigned` compartment. comparable across methods. - This page reports clean PDC `full_common` outputs only, not stale A100 salvage runs or smoke-only results. -- Non-recovery of a canonical axis in the common-db benchmark can reflect LR - resource coverage, expression filtering, or panel detectability rather than - biological absence. +- Non-recovery of a canonical axis in the common-db benchmark can reflect CCI + resource coverage, ligand-receptor-resource filtering, or panel detectability + rather than biological absence. ## Next steps diff --git a/docs/tutorials/ligand_receptor_index.md b/docs/tutorials/cci_index.md similarity index 53% rename from docs/tutorials/ligand_receptor_index.md rename to docs/tutorials/cci_index.md index b51f10a..ab41ef8 100644 --- a/docs/tutorials/ligand_receptor_index.md +++ b/docs/tutorials/cci_index.md @@ -1,29 +1,30 @@ -# pyXenium.ligand_receptor +# pyXenium.cci ```{toctree} :hidden: :maxdepth: 1 -ligand_receptor -ligand_receptor_benchmarking +cci +cci_benchmarking ``` -The ligand-receptor tutorials collect the Atera WTA breast workflows for -topology-supported LR discovery and whole-dataset method benchmarking. +The cell-cell interaction tutorials collect the Atera WTA breast workflows for +topology-supported CCI discovery, including ligand-receptor-resource mode, and +whole-dataset method benchmarking. ::::{grid} 1 1 2 2 :gutter: 2 -:::{grid-item-card} Basic Atera Ligand-Receptor Workflow -:link: ligand_receptor +:::{grid-item-card} Basic Atera Cell-Cell Interaction Workflow +:link: cci :link-type: doc Use precomputed topology anchors and cell-type expression support to interpret sender-receiver hypotheses across tumor, stromal, immune, and vascular compartments. ::: -:::{grid-item-card} Whole-Dataset LR Benchmarking -:link: ligand_receptor_benchmarking +:::{grid-item-card} Whole-Dataset CCI Benchmarking +:link: cci_benchmarking :link-type: doc Compare PDC full common-db runs for pyXenium, CellPhoneDB, LARIS, LIANA+, SpatialDM, and stLearn, with canonical Atera axis recovery and method diff --git a/docs/tutorials/contour_boundary_ecology.ipynb b/docs/tutorials/contour_boundary_ecology.ipynb index 3ce2829..a8f3464 100644 --- a/docs/tutorials/contour_boundary_ecology.ipynb +++ b/docs/tutorials/contour_boundary_ecology.ipynb @@ -42,7 +42,7 @@ "\n", "Recent histology-plus-spatial-transcriptomics methods motivate this workflow, but pyXenium intentionally keeps v1 interpretable. [STPath](https://www.nature.com/articles/s41746-025-02020-3) motivates joint whole-slide image and spatial transcriptomics modeling; [Hist2ST](https://academic.oup.com/bib/article-abstract/23/5/bbac297/6645485) motivates local image patch plus spatial-neighborhood representations; [iIMPACT](https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03289-5) motivates histology-assisted spatial domain discovery; [TITAN](https://www.nature.com/articles/s41591-025-03982-3) motivates optional foundation-model embeddings.\n", "\n", - "This tutorial uses the pathomics-first branch: color, texture, edge density, nuclear-density proxy, shape, rim contrasts, pseudobulk RNA, pathway summaries, ligand-receptor summaries, and matched controls. A foundation model can later be passed through `embedding_backend`, but it is not required for this example." + "This tutorial uses the pathomics-first branch: color, texture, edge density, nuclear-density proxy, shape, rim contrasts, pseudobulk RNA, pathway summaries, cell-cell interaction summaries, and matched controls. A foundation model can later be passed through `embedding_backend`, but it is not required for this example." ] }, { diff --git a/docs/tutorials/index.md b/docs/tutorials/index.md index be05622..c5405a5 100644 --- a/docs/tutorials/index.md +++ b/docs/tutorials/index.md @@ -5,7 +5,7 @@ :maxdepth: 1 pyXenium.io -pyXenium.ligand_receptor +pyXenium.cci pyXenium.pathway pyXenium.multimodal pyXenium.contour @@ -31,11 +31,11 @@ components, and see how I/O preserves the structures needed for downstream biology. ::: -:::{grid-item-card} pyXenium.ligand_receptor -:link: ligand_receptor_index +:::{grid-item-card} pyXenium.cci +:link: cci_index :link-type: doc -Walk through Atera WTA breast ligand-receptor topology outputs, then compare -whole-dataset benchmark results across spatial and non-spatial LR methods. +Walk through Atera WTA breast cell-cell interaction topology outputs, then compare +whole-dataset benchmark results across spatial and non-spatial CCI methods. ::: :::{grid-item-card} pyXenium.pathway diff --git a/docs/tutorials/multimodal_bmnet_he_morphology_pdc.md b/docs/tutorials/multimodal_bmnet_he_morphology_pdc.md index 16c80ac..c2359bf 100644 --- a/docs/tutorials/multimodal_bmnet_he_morphology_pdc.md +++ b/docs/tutorials/multimodal_bmnet_he_morphology_pdc.md @@ -66,7 +66,7 @@ The completed smoke run used the Atera WTA FFPE breast cancer Xenium export on PDC: ```text -/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs +/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs ``` The expected input files are: @@ -89,7 +89,7 @@ From the staged pyXenium repository on PDC: ```bash export PDC_ROOT=/cfs/klemming/scratch/h/hutaobo/pyxenium_bmnet_morphology_2026-04 -export PDC_XENIUM_ROOT=/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs +export PDC_XENIUM_ROOT=/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs bash benchmarking/bmnet_pdc/scripts/bootstrap_pdc_env.sh ``` diff --git a/docs/tutorials/multimodal_rna_contour_he.ipynb b/docs/tutorials/multimodal_rna_contour_he.ipynb index d8fee09..f1dd9c9 100644 --- a/docs/tutorials/multimodal_rna_contour_he.ipynb +++ b/docs/tutorials/multimodal_rna_contour_he.ipynb @@ -42,7 +42,7 @@ "\n", "This broader multimodal pattern is useful whenever a Xenium sample has aligned H&E imagery and biological regions represented as contours. Recent histology-plus-spatial-transcriptomics methods motivate the workflow, but pyXenium intentionally keeps v1 interpretable. [STPath](https://www.nature.com/articles/s41746-025-02020-3) motivates joint whole-slide image and spatial transcriptomics modeling; [Hist2ST](https://academic.oup.com/bib/article-abstract/23/5/bbac297/6645485) motivates local image patch plus spatial-neighborhood representations; [iIMPACT](https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03289-5) motivates histology-assisted spatial domain discovery; [TITAN](https://www.nature.com/articles/s41591-025-03982-3) motivates optional foundation-model embeddings.\n", "\n", - "This tutorial uses the pathomics-first branch: color, texture, edge density, nuclear-density proxy, shape, rim contrasts, pseudobulk RNA, pathway summaries, ligand-receptor summaries, and matched controls. A foundation model can later be passed through `embedding_backend`, but it is not required for this example." + "This tutorial uses the pathomics-first branch: color, texture, edge density, nuclear-density proxy, shape, rim contrasts, pseudobulk RNA, pathway summaries, cell-cell interaction summaries, and matched controls. A foundation model can later be passed through `embedding_backend`, but it is not required for this example." ] }, { diff --git a/docs/tutorials/pathway.ipynb b/docs/tutorials/pathway.ipynb index e7aa76d..7a6da8b 100644 --- a/docs/tutorials/pathway.ipynb +++ b/docs/tutorials/pathway.ipynb @@ -9,7 +9,7 @@ "\n", "## Overview\n", "\n", - "This notebook uses the same Atera WTA breast reproducibility bundle as the ligand-receptor walkthrough, but shifts the focus to pathway-level organization. It compares gene-topology aggregation against activity point-cloud scoring and shows how each view emphasizes different spatial programs.\n", + "This notebook uses the same Atera WTA breast reproducibility bundle as the cell-cell interaction walkthrough, but shifts the focus to pathway-level organization. It compares gene-topology aggregation against activity point-cloud scoring and shows how each view emphasizes different spatial programs.\n", "\n", "## Biological question\n", "\n", @@ -475,7 +475,7 @@ "\n", "## Next steps\n", "\n", - "- Revisit the `ligand_receptor` notebook if you want to connect pathway programs to explicit sender-receiver pairs.\n", + "- Revisit the `cci` notebook if you want to connect pathway programs to explicit sender-receiver pairs.\n", "- Replace the default pathway panel with a custom pathway table when you have a cohort-specific hypothesis.\n", "- Compare intrinsic and niche-smoothed pathway activity modes when spatial spillover is biologically plausible.\n" ] diff --git a/docs/workflows/atera-contour-boundary-ecology.md b/docs/workflows/atera-contour-boundary-ecology.md index fdf5a82..1c61c3c 100644 --- a/docs/workflows/atera-contour-boundary-ecology.md +++ b/docs/workflows/atera-contour-boundary-ecology.md @@ -32,7 +32,7 @@ It expects the standard Xenium export plus: 2. Imports a tutorial-sized subset of Xenium Explorer contours from GeoJSON. 3. Cuts one level-0 H&E patch per contour into `XeniumSData.contour_images`. 4. Builds a contour study table with geometry, pathomics, cell-level - pseudobulk RNA, pathway scores, ligand-receptor summaries, and context + pseudobulk RNA, pathway scores, cell-cell interaction summaries, and context features. 5. Scores the six default boundary programs: `immune_exclusion`, `myeloid_vascular_belt`, `emt_invasive_front`, diff --git a/docs/workflows/atera-contour-gmi.md b/docs/workflows/atera-contour-gmi.md index 8b9a480..94b8da8 100644 --- a/docs/workflows/atera-contour-gmi.md +++ b/docs/workflows/atera-contour-gmi.md @@ -54,7 +54,7 @@ Generate the reproducibility manifest with: ```bash pyxenium gmi pdc-plan \ - --pdc-xenium-root /cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs \ + --pdc-xenium-root /cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs \ --pdc-root /cfs/klemming/scratch/h/hutaobo/pyxenium_gmi_contour_2026-04 \ --output-json /cfs/klemming/scratch/h/hutaobo/pyxenium_gmi_contour_2026-04/logs/pdc_gmi_plan.json ``` diff --git a/docs/workflows/atera-wta-breast-lr-benchmark.md b/docs/workflows/atera-wta-breast-cci-benchmark.md similarity index 64% rename from docs/workflows/atera-wta-breast-lr-benchmark.md rename to docs/workflows/atera-wta-breast-cci-benchmark.md index 78d0448..d951132 100644 --- a/docs/workflows/atera-wta-breast-lr-benchmark.md +++ b/docs/workflows/atera-wta-breast-cci-benchmark.md @@ -1,12 +1,12 @@ -# Atera WTA Breast LR Benchmark +# Atera WTA Breast CCI Benchmark -`pyXenium` ships a dedicated benchmark scaffold for comparing ligand-receptor methods on the Atera Xenium WTA breast dataset used by the LR tutorial. +`pyXenium` ships a dedicated benchmark scaffold for comparing cell-cell interaction methods on the Atera Xenium WTA breast dataset used by the CCI tutorial. ## What This Workflow Produces - a frozen `AnnData` bundle for the full dataset and a stratified smoke subset - sparse cross-language matrices and metadata tables for external Python and R methods -- a shared LR resource table for `common-db` benchmarking +- a shared CCI resource table for `common-db` benchmarking - a standardized output schema across methods - biology-oriented summaries for canonical recovery, pathway relevance, spatial coherence, robustness, and novelty support @@ -15,7 +15,7 @@ The benchmark workspace lives under: ```text -benchmarking/lr_2026_atera/ +benchmarking/cci_2026_atera/ ``` This directory contains: @@ -30,74 +30,74 @@ This directory contains: Prepare the shared input bundle: ```bash -pyxenium benchmark atera-lr prepare +pyxenium benchmark atera-cci prepare ``` Prepare a full sparse bundle locally without requiring a full `.h5ad`: ```bash -pyxenium benchmark atera-lr prepare --skip-full-h5ad +pyxenium benchmark atera-cci prepare --skip-full-h5ad ``` Run the built-in `pyXenium` smoke benchmark: ```bash -pyxenium benchmark atera-lr smoke-pyxenium +pyxenium benchmark atera-cci smoke-pyxenium ``` Dry-run one method adapter: ```bash -pyxenium benchmark atera-lr run-method --method squidpy --database-mode common-db --dry-run +pyxenium benchmark atera-cci run-method --method squidpy --database-mode common-db --dry-run ``` Run the first-wave core smoke panel: ```bash -pyxenium benchmark atera-lr smoke-core --methods pyxenium,squidpy,liana,commot,cellchat --database-mode common-db +pyxenium benchmark atera-cci smoke-core --methods pyxenium,squidpy,liana,commot,cellchat --database-mode common-db ``` Aggregate standardized results: ```bash -pyxenium benchmark atera-lr aggregate +pyxenium benchmark atera-cci aggregate ``` Render a markdown report: ```bash -pyxenium benchmark atera-lr report +pyxenium benchmark atera-cci report ``` Generate A100 staging commands: ```bash -pyxenium benchmark atera-lr stage-a100 --plan-only \ +pyxenium benchmark atera-cci stage-a100 --plan-only \ --remote-xenium-root /mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs \ - --remote-root /data/taobo.hu/pyxenium_lr_benchmark_2026-04 + --remote-root /data/taobo.hu/pyxenium_cci_benchmark_2026-04 ``` -Build and dry-run the A100 full common-db plan. The plan includes a `prepare_full_bundle` job that reads from the read-only `/mnt` Xenium export and writes all bundle/runs/logs/reports under `/data/taobo.hu/pyxenium_lr_benchmark_2026-04`: +Build and dry-run the A100 full common-db plan. The plan includes a `prepare_full_bundle` job that reads from the read-only `/mnt` Xenium export and writes all bundle/runs/logs/reports under `/data/taobo.hu/pyxenium_cci_benchmark_2026-04`: ```bash -pyxenium benchmark atera-lr prepare-a100-bundle --phase full --database-mode common-db \ +pyxenium benchmark atera-cci prepare-a100-bundle --phase full --database-mode common-db \ --remote-xenium-root /mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs \ - --remote-root /data/taobo.hu/pyxenium_lr_benchmark_2026-04 -pyxenium benchmark atera-lr run-a100-plan --plan-json benchmarking/lr_2026_atera/logs/a100_bundle_plan.json + --remote-root /data/taobo.hu/pyxenium_cci_benchmark_2026-04 +pyxenium benchmark atera-cci run-a100-plan --plan-json benchmarking/cci_2026_atera/logs/a100_bundle_plan.json ``` Generate A100 result recovery commands: ```bash -pyxenium benchmark atera-lr collect-a100-results --host --user +pyxenium benchmark atera-cci collect-a100-results --host --user ``` ## Practical Note -The full Xenium matrix is exported as sparse Matrix Market rather than a dense TSV because the full matrix is too large to move or parse safely as a dense text file. The benchmark prep still emits `meta.tsv`, `coords.tsv`, `genes.tsv`, `barcodes.tsv`, and the shared LR tables expected by the method adapters. +The full Xenium matrix is exported as sparse Matrix Market rather than a dense TSV because the full matrix is too large to move or parse safely as a dense text file. The benchmark prep still emits `meta.tsv`, `coords.tsv`, `genes.tsv`, `barcodes.tsv`, and the shared CCI resource tables expected by the method adapters. The first-wave real adapter contract covers `pyXenium`, `Squidpy ligrec`, `LIANA+ spatial bivariate`, `COMMOT`, and `CellChat v3 / SpatialCellChat`. Third-party package installation remains isolated per method environment; missing packages should fail inside the method run with a reproducible `run_summary.json` rather than changing the shared schema. Use the declared per-method environments rather than a base Python environment. In particular, the Squidpy environment pins `zarr<3` because current `spatialdata`/`ome-zarr` stacks can fail to import against incompatible zarr releases. -A100 orchestration writes a portable stage/job manifest and never stores passwords. The A100 source/destination split is explicit: `/mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs` is read-only input, while `/data/taobo.hu/pyxenium_lr_benchmark_2026-04` is the only writable benchmark root. The report step automatically includes run status, engineering reproducibility, canonical pair rank matrix, and A100 resource summary when the corresponding run summaries or A100 plan exist. +A100 orchestration writes a portable stage/job manifest and never stores passwords. The A100 source/destination split is explicit: `/mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs` is read-only input, while `/data/taobo.hu/pyxenium_cci_benchmark_2026-04` is the only writable benchmark root. The report step automatically includes run status, engineering reproducibility, canonical pair rank matrix, and A100 resource summary when the corresponding run summaries or A100 plan exist. diff --git a/docs/workflows/atera-wta-breast-topology.md b/docs/workflows/atera-wta-breast-topology.md index cb98ec2..a50de8d 100644 --- a/docs/workflows/atera-wta-breast-topology.md +++ b/docs/workflows/atera-wta-breast-topology.md @@ -4,7 +4,7 @@ Core entrypoints: -- `pyXenium.ligand_receptor.ligand_receptor_topology_analysis` +- `pyXenium.cci.cci_topology_analysis` - `pyXenium.pathway.pathway_topology_analysis` - `pyXenium.pathway.compute_pathway_activity_matrix` - `pyXenium.validation.run_atera_wta_breast_topology` diff --git a/docs/workflows/index.md b/docs/workflows/index.md index fc8472a..d85963e 100644 --- a/docs/workflows/index.md +++ b/docs/workflows/index.md @@ -8,7 +8,7 @@ atera-wta-breast-topology atera-breast-contour atera-contour-boundary-ecology atera-contour-gmi -atera-wta-breast-lr-benchmark +atera-wta-breast-cci-benchmark ``` Workflows package higher-level, reproducible analyses around the lower-level APIs. They are intended diff --git a/manuscript/atera_wta_breast_topology/lr_component_diagnostics.csv b/manuscript/atera_wta_breast_topology/cci_component_diagnostics.csv similarity index 99% rename from manuscript/atera_wta_breast_topology/lr_component_diagnostics.csv rename to manuscript/atera_wta_breast_topology/cci_component_diagnostics.csv index 363e700..4f15018 100644 --- a/manuscript/atera_wta_breast_topology/lr_component_diagnostics.csv +++ b/manuscript/atera_wta_breast_topology/cci_component_diagnostics.csv @@ -1,4 +1,4 @@ -ligand,receptor,sender_celltype,receiver_celltype,anchor_source_ligand,anchor_source_receptor,structure_map_source,sender_anchor,receiver_anchor,structure_bridge,sender_expr,receiver_expr,local_contact,contact_strength_raw,contact_strength_normalized,contact_coverage,cross_edge_count,prior_confidence,LR_score +ligand,receptor,sender_celltype,receiver_celltype,anchor_source_ligand,anchor_source_receptor,structure_map_source,sender_anchor,receiver_anchor,structure_bridge,sender_expr,receiver_expr,local_contact,contact_strength_raw,contact_strength_normalized,contact_coverage,cross_edge_count,prior_confidence,CCI_score DLL4,NOTCH3,Endothelial Cells,Pericytes,precomputed,precomputed,precomputed,0.8999695474149415,0.8544260293908458,0.9385210026241833,1.0,0.8672894033034337,0.13546509820769403,0.11102322992647283,1.0,0.03031900870023728,11379,1.0,0.6628108852003319 CXCL12,CXCR4,"CAFs, DCIS Associated",T Lymphocytes,precomputed,precomputed,precomputed,0.8401391037337905,0.929067454422166,0.493435580121531,1.0,1.0,0.16843041721620092,0.1342601297358261,1.0,0.04507066528783178,11604,1.0,0.6338817490290192 TGFB1,TGFBR2,Endothelial Cells,Endothelial Cells,precomputed,precomputed,precomputed,0.7421690557741022,0.9670990634749379,1.0,0.5918084951805068,1.0,0.05166516495327473,0.0322143099355713,0.5136270386044376,0.006808044447922373,12779,1.0,0.5291256583902569 diff --git a/manuscript/atera_wta_breast_topology/lr_sender_receiver_scores.csv b/manuscript/atera_wta_breast_topology/cci_sender_receiver_scores.csv similarity index 99% rename from manuscript/atera_wta_breast_topology/lr_sender_receiver_scores.csv rename to manuscript/atera_wta_breast_topology/cci_sender_receiver_scores.csv index 363e700..4f15018 100644 --- a/manuscript/atera_wta_breast_topology/lr_sender_receiver_scores.csv +++ b/manuscript/atera_wta_breast_topology/cci_sender_receiver_scores.csv @@ -1,4 +1,4 @@ -ligand,receptor,sender_celltype,receiver_celltype,anchor_source_ligand,anchor_source_receptor,structure_map_source,sender_anchor,receiver_anchor,structure_bridge,sender_expr,receiver_expr,local_contact,contact_strength_raw,contact_strength_normalized,contact_coverage,cross_edge_count,prior_confidence,LR_score +ligand,receptor,sender_celltype,receiver_celltype,anchor_source_ligand,anchor_source_receptor,structure_map_source,sender_anchor,receiver_anchor,structure_bridge,sender_expr,receiver_expr,local_contact,contact_strength_raw,contact_strength_normalized,contact_coverage,cross_edge_count,prior_confidence,CCI_score DLL4,NOTCH3,Endothelial Cells,Pericytes,precomputed,precomputed,precomputed,0.8999695474149415,0.8544260293908458,0.9385210026241833,1.0,0.8672894033034337,0.13546509820769403,0.11102322992647283,1.0,0.03031900870023728,11379,1.0,0.6628108852003319 CXCL12,CXCR4,"CAFs, DCIS Associated",T Lymphocytes,precomputed,precomputed,precomputed,0.8401391037337905,0.929067454422166,0.493435580121531,1.0,1.0,0.16843041721620092,0.1342601297358261,1.0,0.04507066528783178,11604,1.0,0.6338817490290192 TGFB1,TGFBR2,Endothelial Cells,Endothelial Cells,precomputed,precomputed,precomputed,0.7421690557741022,0.9670990634749379,1.0,0.5918084951805068,1.0,0.05166516495327473,0.0322143099355713,0.5136270386044376,0.006808044447922373,12779,1.0,0.5291256583902569 diff --git a/manuscript/atera_wta_breast_topology/figures/lr_hotspot_cells.csv b/manuscript/atera_wta_breast_topology/figures/cci_hotspot_cells.csv similarity index 100% rename from manuscript/atera_wta_breast_topology/figures/lr_hotspot_cells.csv rename to manuscript/atera_wta_breast_topology/figures/cci_hotspot_cells.csv diff --git a/manuscript/atera_wta_breast_topology/figures/lr_hotspot_cells.parquet b/manuscript/atera_wta_breast_topology/figures/cci_hotspot_cells.parquet similarity index 100% rename from manuscript/atera_wta_breast_topology/figures/lr_hotspot_cells.parquet rename to manuscript/atera_wta_breast_topology/figures/cci_hotspot_cells.parquet diff --git a/manuscript/atera_wta_breast_topology/figures/lr_hotspot_overlay.pdf b/manuscript/atera_wta_breast_topology/figures/cci_hotspot_overlay.pdf similarity index 100% rename from manuscript/atera_wta_breast_topology/figures/lr_hotspot_overlay.pdf rename to manuscript/atera_wta_breast_topology/figures/cci_hotspot_overlay.pdf diff --git a/manuscript/atera_wta_breast_topology/figures/lr_hotspot_overlay.png b/manuscript/atera_wta_breast_topology/figures/cci_hotspot_overlay.png similarity index 100% rename from manuscript/atera_wta_breast_topology/figures/lr_hotspot_overlay.png rename to manuscript/atera_wta_breast_topology/figures/cci_hotspot_overlay.png diff --git a/manuscript/atera_wta_breast_topology/figures/lr_summary_heatmap.pdf b/manuscript/atera_wta_breast_topology/figures/cci_summary_heatmap.pdf similarity index 100% rename from manuscript/atera_wta_breast_topology/figures/lr_summary_heatmap.pdf rename to manuscript/atera_wta_breast_topology/figures/cci_summary_heatmap.pdf diff --git a/manuscript/atera_wta_breast_topology/figures/lr_summary_heatmap.png b/manuscript/atera_wta_breast_topology/figures/cci_summary_heatmap.png similarity index 100% rename from manuscript/atera_wta_breast_topology/figures/lr_summary_heatmap.png rename to manuscript/atera_wta_breast_topology/figures/cci_summary_heatmap.png diff --git a/manuscript/atera_wta_breast_topology/summary.json b/manuscript/atera_wta_breast_topology/summary.json index 59ae576..1f2b681 100644 --- a/manuscript/atera_wta_breast_topology/summary.json +++ b/manuscript/atera_wta_breast_topology/summary.json @@ -102,7 +102,7 @@ "panel_name": "Human WTA (pre-release)", "analysis_sw_version": "xenium-9.9.9.9" }, - "lr_smoke_panel": [ + "cci_smoke_panel": [ { "ligand": "CSF1", "receptor": "CSF1R", @@ -187,7 +187,7 @@ ] } ], - "lr_pair_summaries": [ + "cci_pair_summaries": [ { "ligand": "CSF1", "receptor": "CSF1R", @@ -198,27 +198,27 @@ { "sender_celltype": "CAFs, DCIS Associated", "receiver_celltype": "Macrophages", - "LR_score": 0.5073865151280754 + "CCI_score": 0.5073865151280754 }, { "sender_celltype": "Endothelial Cells", "receiver_celltype": "Macrophages", - "LR_score": 0.35154104870596287 + "CCI_score": 0.35154104870596287 }, { "sender_celltype": "CAFs, DCIS Associated", "receiver_celltype": "Dendritic Cells", - "LR_score": 0.34326136269645735 + "CCI_score": 0.34326136269645735 }, { "sender_celltype": "Pericytes", "receiver_celltype": "Macrophages", - "LR_score": 0.33750315954595617 + "CCI_score": 0.33750315954595617 }, { "sender_celltype": "Mast Cells", "receiver_celltype": "Macrophages", - "LR_score": 0.2749259699199151 + "CCI_score": 0.2749259699199151 } ] }, @@ -232,27 +232,27 @@ { "sender_celltype": "CAFs, DCIS Associated", "receiver_celltype": "T Lymphocytes", - "LR_score": 0.6338817490290192 + "CCI_score": 0.6338817490290192 }, { "sender_celltype": "CAFs, DCIS Associated", "receiver_celltype": "Dendritic Cells", - "LR_score": 0.3944579384584832 + "CCI_score": 0.3944579384584832 }, { "sender_celltype": "Endothelial Cells", "receiver_celltype": "T Lymphocytes", - "LR_score": 0.3019627849314387 + "CCI_score": 0.3019627849314387 }, { "sender_celltype": "CAFs, DCIS Associated", "receiver_celltype": "Macrophages", - "LR_score": 0.29324002045756453 + "CCI_score": 0.29324002045756453 }, { "sender_celltype": "Pericytes", "receiver_celltype": "T Lymphocytes", - "LR_score": 0.26668552231862974 + "CCI_score": 0.26668552231862974 } ] }, @@ -266,27 +266,27 @@ { "sender_celltype": "Endothelial Cells", "receiver_celltype": "Endothelial Cells", - "LR_score": 0.5291256583902569 + "CCI_score": 0.5291256583902569 }, { "sender_celltype": "T Lymphocytes", "receiver_celltype": "Endothelial Cells", - "LR_score": 0.4854183473543701 + "CCI_score": 0.4854183473543701 }, { "sender_celltype": "CAFs, Invasive Associated", "receiver_celltype": "Endothelial Cells", - "LR_score": 0.4457506759627043 + "CCI_score": 0.4457506759627043 }, { "sender_celltype": "Dendritic Cells", "receiver_celltype": "Endothelial Cells", - "LR_score": 0.42448941983499283 + "CCI_score": 0.42448941983499283 }, { "sender_celltype": "Macrophages", "receiver_celltype": "Endothelial Cells", - "LR_score": 0.41532289004992023 + "CCI_score": 0.41532289004992023 } ] }, @@ -300,27 +300,27 @@ { "sender_celltype": "11q13 Invasive Tumor Cells", "receiver_celltype": "Basal-like Structured DCIS Cells", - "LR_score": 0.5029093013588464 + "CCI_score": 0.5029093013588464 }, { "sender_celltype": "11q13 Invasive Tumor Cells", "receiver_celltype": "11q13 Invasive Tumor Cells", - "LR_score": 0.47428572234409616 + "CCI_score": 0.47428572234409616 }, { "sender_celltype": "11q13 Invasive Tumor Cells", "receiver_celltype": "Endothelial Cells", - "LR_score": 0.41047474995774563 + "CCI_score": 0.41047474995774563 }, { "sender_celltype": "11q13 Invasive Tumor Cells", "receiver_celltype": "11q13 Invasive Tumor Cells (Mitotic)", - "LR_score": 0.29793464530167624 + "CCI_score": 0.29793464530167624 }, { "sender_celltype": "11q13 Invasive Tumor Cells", "receiver_celltype": "Pericytes", - "LR_score": 0.2963946101502821 + "CCI_score": 0.2963946101502821 } ] }, @@ -334,32 +334,32 @@ { "sender_celltype": "Endothelial Cells", "receiver_celltype": "Pericytes", - "LR_score": 0.6628108852003319 + "CCI_score": 0.6628108852003319 }, { "sender_celltype": "Endothelial Cells", "receiver_celltype": "Endothelial Cells", - "LR_score": 0.47241153359396243 + "CCI_score": 0.47241153359396243 }, { "sender_celltype": "Endothelial Cells", "receiver_celltype": "11q13 Invasive Tumor Cells", - "LR_score": 0.41116804232785686 + "CCI_score": 0.41116804232785686 }, { "sender_celltype": "Pericytes", "receiver_celltype": "Pericytes", - "LR_score": 0.34812852252139787 + "CCI_score": 0.34812852252139787 }, { "sender_celltype": "Endothelial Cells", "receiver_celltype": "CAFs, Invasive Associated", - "LR_score": 0.3222123016963357 + "CCI_score": 0.3222123016963357 } ] } ], - "lr_acceptance": [ + "cci_acceptance": [ { "check": "CSF1-CSF1R top sender should not be Mast Cells", "ligand": "CSF1", @@ -502,17 +502,17 @@ "files": { "ligand_to_cell": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\ligand_to_cell.csv", "receptor_to_cell": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\receptor_to_cell.csv", - "lr_sender_receiver_scores": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\lr_sender_receiver_scores.csv", - "lr_component_diagnostics": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\lr_component_diagnostics.csv", - "lr_summary_heatmap": [ - "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\lr_summary_heatmap.png", - "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\lr_summary_heatmap.pdf" + "cci_sender_receiver_scores": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\cci_sender_receiver_scores.csv", + "cci_component_diagnostics": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\cci_component_diagnostics.csv", + "cci_summary_heatmap": [ + "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\cci_summary_heatmap.png", + "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\cci_summary_heatmap.pdf" ], - "lr_hotspot_cells_csv": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\lr_hotspot_cells.csv", - "lr_hotspot_cells_parquet": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\lr_hotspot_cells.parquet", - "lr_hotspot_overlay": [ - "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\lr_hotspot_overlay.png", - "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\lr_hotspot_overlay.pdf" + "cci_hotspot_cells_csv": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\cci_hotspot_cells.csv", + "cci_hotspot_cells_parquet": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\cci_hotspot_cells.parquet", + "cci_hotspot_overlay": [ + "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\cci_hotspot_overlay.png", + "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\figures\\cci_hotspot_overlay.pdf" ], "pathway_to_cell": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\pathway_to_cell.csv", "pathway_structuremap": "D:\\GitHub\\pyXenium\\manuscript\\atera_wta_breast_topology\\pathway_structuremap.csv", diff --git a/manuscript/code/atera_wta_breast_topology.ipynb b/manuscript/code/atera_wta_breast_topology.ipynb index 32e4d3d..a918869 100644 --- a/manuscript/code/atera_wta_breast_topology.ipynb +++ b/manuscript/code/atera_wta_breast_topology.ipynb @@ -72,9 +72,9 @@ "import pandas as pd\n", "\n", "summary = json.loads((output_dir / \"summary.json\").read_text(encoding=\"utf-8\"))\n", - "print(pd.DataFrame(summary['lr_acceptance']).to_string(index=False))\n", + "print(pd.DataFrame(summary['cci_acceptance']).to_string(index=False))\n", "print()\n", - "print(pd.DataFrame(summary['lr_pair_summaries'])[['ligand', 'receptor', 'best_sender_celltype', 'best_receiver_celltype', 'best_score']].to_string(index=False))\n" + "print(pd.DataFrame(summary['cci_pair_summaries'])[['ligand', 'receptor', 'best_sender_celltype', 'best_receiver_celltype', 'best_score']].to_string(index=False))\n" ], "outputs": [ { @@ -106,14 +106,14 @@ "metadata": {}, "execution_count": 5, "source": [ - "top_lr = pd.read_csv(output_dir / 'lr_sender_receiver_scores.csv').head(10)\n", - "print(top_lr[['ligand', 'receptor', 'sender_celltype', 'receiver_celltype', 'LR_score']].to_string(index=False))\n" + "top_cci = pd.read_csv(output_dir / 'cci_sender_receiver_scores.csv').head(10)\n", + "print(top_cci[['ligand', 'receptor', 'sender_celltype', 'receiver_celltype', 'CCI_score']].to_string(index=False))\n" ], "outputs": [ { "output_type": "stream", "name": "stdout", - "text": "ligand receptor sender_celltype receiver_celltype LR_score\n DLL4 NOTCH3 Endothelial Cells Pericytes 0.662811\nCXCL12 CXCR4 CAFs, DCIS Associated T Lymphocytes 0.633882\n TGFB1 TGFBR2 Endothelial Cells Endothelial Cells 0.529126\n CSF1 CSF1R CAFs, DCIS Associated Macrophages 0.507387\n JAG1 NOTCH1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.502909\n TGFB1 TGFBR2 T Lymphocytes Endothelial Cells 0.485418\n JAG1 NOTCH1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.474286\n DLL4 NOTCH3 Endothelial Cells Endothelial Cells 0.472412\n TGFB1 TGFBR2 CAFs, Invasive Associated Endothelial Cells 0.445751\n TGFB1 TGFBR2 Dendritic Cells Endothelial Cells 0.424489\n" + "text": "ligand receptor sender_celltype receiver_celltype CCI_score\n DLL4 NOTCH3 Endothelial Cells Pericytes 0.662811\nCXCL12 CXCR4 CAFs, DCIS Associated T Lymphocytes 0.633882\n TGFB1 TGFBR2 Endothelial Cells Endothelial Cells 0.529126\n CSF1 CSF1R CAFs, DCIS Associated Macrophages 0.507387\n JAG1 NOTCH1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.502909\n TGFB1 TGFBR2 T Lymphocytes Endothelial Cells 0.485418\n JAG1 NOTCH1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.474286\n DLL4 NOTCH3 Endothelial Cells Endothelial Cells 0.472412\n TGFB1 TGFBR2 CAFs, Invasive Associated Endothelial Cells 0.445751\n TGFB1 TGFBR2 Dendritic Cells Endothelial Cells 0.424489\n" } ] }, @@ -125,9 +125,9 @@ "\n", "Primary packaged figures generated by the workflow:\n", "\n", - "![LR summary](../atera_wta_breast_topology/figures/lr_summary_heatmap.png)\n", + "![CCI summary](../atera_wta_breast_topology/figures/cci_summary_heatmap.png)\n", "\n", - "![LR hotspot](../atera_wta_breast_topology/figures/lr_hotspot_overlay.png)\n", + "![CCI hotspot](../atera_wta_breast_topology/figures/cci_hotspot_overlay.png)\n", "\n", "![Pathway primary heatmap](../atera_wta_breast_topology/figures/pathway_to_cell_heatmap.png)\n", "\n", diff --git a/src/pyXenium/__init__.py b/src/pyXenium/__init__.py index e8a9904..edb39a6 100644 --- a/src/pyXenium/__init__.py +++ b/src/pyXenium/__init__.py @@ -9,7 +9,7 @@ "contour": ".contour", "gmi": ".gmi", "io": ".io", - "ligand_receptor": ".ligand_receptor", + "cci": ".cci", "mechanostress": ".mechanostress", "multimodal": ".multimodal", "pathway": ".pathway", @@ -52,7 +52,7 @@ "compute_rna_protein_discordance": (".multimodal", "compute_rna_protein_discordance"), "estimate_cell_axes": (".mechanostress", "estimate_cell_axes"), "extract_ranked_patches": (".multimodal", "extract_ranked_patches"), - "ligand_receptor_topology_analysis": (".ligand_receptor", "ligand_receptor_topology_analysis"), + "cci_topology_analysis": (".cci", "cci_topology_analysis"), "load_anndata_from_partial": (".io", "load_anndata_from_partial"), "load_rna_protein_anndata": (".multimodal", "load_rna_protein_anndata"), "load_xenium_gene_protein": (".io", "load_xenium_gene_protein"), @@ -155,8 +155,8 @@ def __dir__() -> list[str]: "get_public_dataset_sources", "gmi", "io", - "ligand_receptor_topology_analysis", - "ligand_receptor", + "cci_topology_analysis", + "cci", "mechanostress", "load_anndata_from_partial", "load_rna_protein_anndata", diff --git a/src/pyXenium/__main__.py b/src/pyXenium/__main__.py index d7888bc..152dce7 100644 --- a/src/pyXenium/__main__.py +++ b/src/pyXenium/__main__.py @@ -25,10 +25,11 @@ compute_robustness, execute_a100_stage_plan, finalize_a100_all, + finalize_cci_source_of_truth, monitor_a100_jobs, prepare_a100_bundle, - prepare_atera_lr_benchmark, - render_atera_lr_benchmark_report, + prepare_atera_cci_benchmark, + render_atera_cci_benchmark_report, resolve_layout, run_a100_plan, run_registered_method, @@ -104,9 +105,9 @@ def benchmark_group(): """Benchmark orchestration commands.""" -@benchmark_group.group("atera-lr") -def benchmark_atera_lr_group(): - """Atera Xenium ligand-receptor benchmark commands.""" +@benchmark_group.group("atera-cci") +def benchmark_atera_cci_group(): + """Atera Xenium cell-cell interaction benchmark commands.""" @app.group("gmi") @@ -831,7 +832,7 @@ def atera_wta_breast_topology( write_h5ad, export_figures, ): - """Run the fixed Atera WTA breast LR/pathway topology reproducibility workflow.""" + """Run the fixed Atera WTA breast CCI/pathway topology reproducibility workflow.""" study = run_atera_wta_breast_topology( dataset_root=dataset_root, tbc_results=tbc_results, @@ -845,18 +846,18 @@ def atera_wta_breast_topology( click.echo(json.dumps(study["payload"], indent=2)) -@benchmark_atera_lr_group.command("prepare") +@benchmark_atera_cci_group.command("prepare") @click.option("--dataset-root", "--xenium-root", "dataset_root", default=DEFAULT_ATERA_WTA_BREAST_DATASET_PATH, show_default=True) -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--tbc-results", default=None, help="Optional path to the topology bundle directory.") @click.option("--smoke-n-cells", type=int, default=20000, show_default=True) @click.option("--seed", type=int, default=0, show_default=True) @click.option("--prefer", type=click.Choice(["auto", "zarr", "h5", "mex"]), default="h5", show_default=True) @click.option("--export-full-bundle/--skip-full-bundle", default=True, show_default=True) @click.option("--write-full-h5ad/--skip-full-h5ad", default=True, show_default=True) -def benchmark_atera_lr_prepare(dataset_root, benchmark_root, tbc_results, smoke_n_cells, seed, prefer, export_full_bundle, write_full_h5ad): +def benchmark_atera_cci_prepare(dataset_root, benchmark_root, tbc_results, smoke_n_cells, seed, prefer, export_full_bundle, write_full_h5ad): """Freeze the Atera Xenium benchmark inputs and export the cross-language bundle.""" - payload = prepare_atera_lr_benchmark( + payload = prepare_atera_cci_benchmark( dataset_root=dataset_root, benchmark_root=benchmark_root, tbc_results=tbc_results, @@ -869,43 +870,43 @@ def benchmark_atera_lr_prepare(dataset_root, benchmark_root, tbc_results, smoke_ click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("smoke-pyxenium") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("smoke-pyxenium") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--input-h5ad", default=None, help="Optional smoke h5ad path. Defaults to /data/smoke/adata_smoke.h5ad.") @click.option("--output-dir", default=None, help="Optional output directory. Defaults to /runs/pyxenium_smoke.") @click.option("--tbc-results", default=None, help="Optional path to the topology bundle directory.") -@click.option("--lr-panel-path", default=None, help="Optional LR panel TSV. Defaults to /data/atera_smoke_panel.tsv.") +@click.option("--cci-panel-path", default=None, help="Optional CCI resource TSV. Defaults to /data/atera_smoke_panel.tsv.") @click.option("--database-mode", default="smoke-panel", show_default=True) @click.option("--export-figures/--no-export-figures", default=False, show_default=True) -def benchmark_atera_lr_smoke_pyxenium(benchmark_root, input_h5ad, output_dir, tbc_results, lr_panel_path, database_mode, export_figures): +def benchmark_atera_cci_smoke_pyxenium(benchmark_root, input_h5ad, output_dir, tbc_results, cci_panel_path, database_mode, export_figures): """Run the pyXenium smoke benchmark and standardize the result table.""" - layout = resolve_layout(relative_root=benchmark_root or Path("benchmarking") / "lr_2026_atera") + layout = resolve_layout(relative_root=benchmark_root or Path("benchmarking") / "cci_2026_atera") resolved_input_h5ad = input_h5ad or layout.data_dir / "smoke" / "adata_smoke.h5ad" resolved_output_dir = output_dir or layout.runs_dir / "pyxenium_smoke" - resolved_lr_panel = lr_panel_path or layout.data_dir / "atera_smoke_panel.tsv" + resolved_cci_panel = cci_panel_path or layout.data_dir / "atera_smoke_panel.tsv" resolved_tbc = tbc_results or Path(DEFAULT_ATERA_WTA_BREAST_DATASET_PATH) / DEFAULT_ATERA_WTA_BREAST_TBC_SUBDIR payload = run_pyxenium_smoke( input_h5ad=resolved_input_h5ad, output_dir=resolved_output_dir, tbc_results=resolved_tbc, - lr_panel_path=resolved_lr_panel, + cci_panel_path=resolved_cci_panel, database_mode=database_mode, export_figures=export_figures, ) click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("run-method") -@click.option("--method", required=True, help="Registered LR benchmark method slug, e.g. squidpy, liana, commot, cellchat.") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("run-method") +@click.option("--method", required=True, help="Registered CCI benchmark method slug, e.g. squidpy, liana, commot, cellchat.") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--input-manifest", default=None, help="Optional input manifest. Defaults to /data/input_manifest.json.") @click.option("--output-dir", default=None, help="Optional output directory. Defaults to /runs/__.") @click.option("--database-mode", default="common-db", show_default=True, help="common-db, native-db, or smoke-panel.") @click.option("--phase", type=click.Choice(["smoke", "full"]), default="smoke", show_default=True) -@click.option("--max-lr-pairs", type=int, default=None, help="Optional cap for pilot runs.") +@click.option("--max-cci-pairs", type=int, default=None, help="Optional cap for pilot runs.") @click.option("--n-perms", type=int, default=100, show_default=True, help="Permutation count for adapters that expose permutations.") -@click.option("--chunk-id", type=int, default=None, help="Optional zero-based LR chunk id for chunked methods.") -@click.option("--num-chunks", type=int, default=None, help="Optional total LR chunks for chunked methods.") +@click.option("--chunk-id", type=int, default=None, help="Optional zero-based CCI chunk id for chunked methods.") +@click.option("--num-chunks", type=int, default=None, help="Optional total CCI chunks for chunked methods.") @click.option("--bounded-mode", default=None, help="Optional bounded execution label, e.g. smoke_20k, pilot_50k, commot_chunk.") @click.option("--gpu-id", default=None, help="Optional GPU id assigned by the A100 job matrix.") @click.option("--job-id", default=None, help="Optional A100 job id/provenance label.") @@ -914,14 +915,14 @@ def benchmark_atera_lr_smoke_pyxenium(benchmark_root, input_h5ad, output_dir, tb @click.option("--export-figures/--no-export-figures", default=False, show_default=True) @click.option("--rscript", default=None, help="Optional Rscript executable for CellChat.") @click.option("--dry-run", is_flag=True, default=False, help="Validate the run contract without executing the adapter.") -def benchmark_atera_lr_run_method( +def benchmark_atera_cci_run_method( method, benchmark_root, input_manifest, output_dir, database_mode, phase, - max_lr_pairs, + max_cci_pairs, n_perms, chunk_id, num_chunks, @@ -934,7 +935,7 @@ def benchmark_atera_lr_run_method( rscript, dry_run, ): - """Run one real LR benchmark adapter using the unified contract.""" + """Run one real CCI benchmark adapter using the unified contract.""" if dry_run: payload = build_method_run_plan( method=method, @@ -943,7 +944,7 @@ def benchmark_atera_lr_run_method( benchmark_root=benchmark_root, database_mode=database_mode, phase=phase, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, chunk_id=chunk_id, num_chunks=num_chunks, @@ -960,7 +961,7 @@ def benchmark_atera_lr_run_method( benchmark_root=benchmark_root, database_mode=database_mode, phase=phase, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, chunk_id=chunk_id, num_chunks=num_chunks, @@ -975,24 +976,24 @@ def benchmark_atera_lr_run_method( click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("smoke-core") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("smoke-core") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--input-manifest", default=None, help="Optional input manifest. Defaults to /data/input_manifest.json.") @click.option("--methods", default="pyxenium,squidpy,liana,commot,cellchat", show_default=True, help="Comma-separated method slugs.") @click.option("--database-mode", default="common-db", show_default=True, help="common-db, native-db, or smoke-panel.") -@click.option("--max-lr-pairs", type=int, default=None, help="Optional cap for pilot runs.") +@click.option("--max-cci-pairs", type=int, default=None, help="Optional cap for pilot runs.") @click.option("--n-perms", type=int, default=100, show_default=True, help="Permutation count for adapters that expose permutations.") @click.option("--dry-run", is_flag=True, default=False, help="Validate all method contracts without executing adapters.") @click.option("--continue-on-error/--strict", default=True, show_default=True) -def benchmark_atera_lr_smoke_core(benchmark_root, input_manifest, methods, database_mode, max_lr_pairs, n_perms, dry_run, continue_on_error): - """Run or dry-run the core LR adapter smoke benchmark.""" +def benchmark_atera_cci_smoke_core(benchmark_root, input_manifest, methods, database_mode, max_cci_pairs, n_perms, dry_run, continue_on_error): + """Run or dry-run the core CCI adapter smoke benchmark.""" method_list = [item.strip() for item in methods.split(",") if item.strip()] payload = run_smoke_core( methods=method_list, input_manifest=input_manifest, benchmark_root=benchmark_root, database_mode=database_mode, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, dry_run=dry_run, continue_on_error=continue_on_error, @@ -1000,13 +1001,13 @@ def benchmark_atera_lr_smoke_core(benchmark_root, input_manifest, methods, datab click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("aggregate") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("aggregate") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--result-path", "result_paths", multiple=True, help="One or more standardized TSV files.") @click.option("--output-path", default=None, help="Optional output path. Defaults to /results/combined_standardized.tsv.") -def benchmark_atera_lr_aggregate(benchmark_root, result_paths, output_path): - """Aggregate one or more standardized LR result tables.""" - layout = resolve_layout(relative_root=benchmark_root or Path("benchmarking") / "lr_2026_atera") +def benchmark_atera_cci_aggregate(benchmark_root, result_paths, output_path): + """Aggregate one or more standardized CCI result tables.""" + layout = resolve_layout(relative_root=benchmark_root or Path("benchmarking") / "cci_2026_atera") discovered = sorted([*layout.runs_dir.glob("**/*standardized*.tsv"), *layout.runs_dir.glob("**/*standardized*.tsv.gz")]) selected = list(result_paths) if result_paths else [str(path) for path in discovered] if not selected: @@ -1016,15 +1017,15 @@ def benchmark_atera_lr_aggregate(benchmark_root, result_paths, output_path): click.echo(json.dumps({"output_path": str(resolved_output), "n_rows": int(len(combined)), "inputs": selected}, indent=2)) -@benchmark_atera_lr_group.command("report") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("report") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--combined-results", default=None, help="Optional aggregated standardized TSV path.") @click.option("--canonical-config", default=None, help="Optional canonical axes YAML path.") @click.option("--pathway-config", default=None, help="Optional pathway YAML path.") @click.option("--output-path", default=None, help="Optional markdown report path.") -def benchmark_atera_lr_report(benchmark_root, combined_results, canonical_config, pathway_config, output_path): +def benchmark_atera_cci_report(benchmark_root, combined_results, canonical_config, pathway_config, output_path): """Build a markdown report from standardized benchmark outputs.""" - layout = resolve_layout(relative_root=benchmark_root or Path("benchmarking") / "lr_2026_atera") + layout = resolve_layout(relative_root=benchmark_root or Path("benchmarking") / "cci_2026_atera") combined_path = Path(combined_results) if combined_results else layout.results_dir / "combined_standardized.tsv" if not combined_path.exists(): raise click.ClickException(f"Combined standardized table does not exist: {combined_path}") @@ -1052,7 +1053,7 @@ def benchmark_atera_lr_report(benchmark_root, combined_results, canonical_config robustness_summary=robustness_summary, novelty_summary=novelty_summary, ) - markdown = render_atera_lr_benchmark_report( + markdown = render_atera_cci_benchmark_report( combined_results=combined, canonical_summary=canonical_summary, pathway_summary=pathway_summary, @@ -1069,8 +1070,8 @@ def benchmark_atera_lr_report(benchmark_root, combined_results, canonical_config click.echo(json.dumps({"report_md": str(resolved_output), "n_methods": int(combined["method"].nunique()) if not combined.empty else 0}, indent=2)) -@benchmark_atera_lr_group.command("stage-a100") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("stage-a100") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--host", default=None, help="Remote SSH host or IP.") @click.option("--user", default=None, help="Remote SSH username.") @click.option("--remote-root", default=DEFAULT_A100_REMOTE_ROOT, show_default=True) @@ -1081,7 +1082,7 @@ def benchmark_atera_lr_report(benchmark_root, combined_results, canonical_config @click.option("--output-json", default=None, help="Optional JSON path to persist the staging manifest.") @click.option("--plan-only", is_flag=True, default=False, help="Generate a host-agnostic A100 stage plan without requiring host/user.") @click.option("--dry-run/--execute", default=True, show_default=True, help="When executing, run mkdir + transfer commands immediately.") -def benchmark_atera_lr_stage_a100(benchmark_root, host, user, remote_root, remote_xenium_root, stage_data, transfer_mode, include_paths, output_json, plan_only, dry_run): +def benchmark_atera_cci_stage_a100(benchmark_root, host, user, remote_root, remote_xenium_root, stage_data, transfer_mode, include_paths, output_json, plan_only, dry_run): """Generate SSH/SCP commands for staging the benchmark to A100.""" payload = build_a100_stage_plan( benchmark_root=benchmark_root, @@ -1105,15 +1106,15 @@ def benchmark_atera_lr_stage_a100(benchmark_root, host, user, remote_root, remot click.echo(json.dumps(response, indent=2)) -@benchmark_atera_lr_group.command("prepare-a100-bundle") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("prepare-a100-bundle") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--remote-root", default=DEFAULT_A100_REMOTE_ROOT, show_default=True) @click.option("--remote-xenium-root", default=DEFAULT_A100_READONLY_XENIUM_ROOT, show_default=True, help="Read-only Xenium outs path on A100.") @click.option("--transfer-mode", type=click.Choice(["auto", "rsync", "scp", "tar-scp"]), default="auto", show_default=True) @click.option("--methods", default="pyxenium,squidpy,liana,commot,cellchat", show_default=True) @click.option("--database-mode", default="common-db", show_default=True) @click.option("--phase", type=click.Choice(["smoke", "full"]), default="full", show_default=True) -@click.option("--max-lr-pairs", type=int, default=None) +@click.option("--max-cci-pairs", type=int, default=None) @click.option("--n-perms", type=int, default=100, show_default=True) @click.option("--include-prepare/--skip-prepare", default=True, show_default=True, help="Include the A100 job that builds full sparse bundle from the read-only Xenium root.") @click.option("--stage-data/--skip-data", default=None, help="Whether to copy local data in the stage plan. Defaults to skip with remote Xenium root.") @@ -1124,7 +1125,7 @@ def benchmark_atera_lr_stage_a100(benchmark_root, host, user, remote_root, remot @click.option("--user", default=None) @click.option("--require-full/--allow-missing-full", default=True, show_default=True) @click.option("--output-json", default=None) -def benchmark_atera_lr_prepare_a100_bundle( +def benchmark_atera_cci_prepare_a100_bundle( benchmark_root, remote_root, remote_xenium_root, @@ -1132,7 +1133,7 @@ def benchmark_atera_lr_prepare_a100_bundle( methods, database_mode, phase, - max_lr_pairs, + max_cci_pairs, n_perms, include_prepare, stage_data, @@ -1153,7 +1154,7 @@ def benchmark_atera_lr_prepare_a100_bundle( methods=[item.strip() for item in methods.split(",") if item.strip()], database_mode=database_mode, phase=phase, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, require_full=require_full, include_prepare=include_prepare, @@ -1168,14 +1169,14 @@ def benchmark_atera_lr_prepare_a100_bundle( click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("run-a100-plan") +@benchmark_atera_cci_group.command("run-a100-plan") @click.option("--plan-json", required=True, help="A100 job manifest or bundle plan JSON.") @click.option("--job-id", "job_ids", multiple=True, help="Optional job id filter.") @click.option("--dry-run/--execute", default=True, show_default=True) @click.option("--remote/--local", default=False, show_default=True, help="Execute the plan over SSH instead of locally.") @click.option("--host", default=None, help="Remote SSH host or IP.") @click.option("--user", default=None, help="Remote SSH username.") -def benchmark_atera_lr_run_a100_plan(plan_json, job_ids, dry_run, remote, host, user): +def benchmark_atera_cci_run_a100_plan(plan_json, job_ids, dry_run, remote, host, user): """Dry-run or execute commands from an A100 job manifest.""" payload = run_a100_plan( plan_json=plan_json, @@ -1188,30 +1189,32 @@ def benchmark_atera_lr_run_a100_plan(plan_json, job_ids, dry_run, remote, host, click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("build-a100-matrix") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("build-a100-matrix") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--remote-root", default=DEFAULT_A100_REMOTE_ROOT, show_default=True) @click.option("--methods", default=",".join(DEFAULT_A100_ALL_METHODS), show_default=True) @click.option("--database-mode", default="common-db", show_default=True) @click.option("--phase", type=click.Choice(["smoke", "full"]), default="smoke", show_default=True) -@click.option("--max-lr-pairs", type=int, default=None) +@click.option("--max-cci-pairs", type=int, default=None) @click.option("--n-perms", type=int, default=100, show_default=True) @click.option("--commot-chunks", type=int, default=16, show_default=True) +@click.option("--cellagentchat-chunks", type=int, default=16, show_default=True) @click.option("--gpu-count", type=int, default=8, show_default=True) @click.option("--gzip-edge-outputs/--plain-edge-outputs", default=True, show_default=True) @click.option("--include-bootstrap", is_flag=True, default=False) @click.option("--include-audit", is_flag=True, default=False) @click.option("--repeat-id", default=None) @click.option("--output-json", default=None) -def benchmark_atera_lr_build_a100_matrix( +def benchmark_atera_cci_build_a100_matrix( benchmark_root, remote_root, methods, database_mode, phase, - max_lr_pairs, + max_cci_pairs, n_perms, commot_chunks, + cellagentchat_chunks, gpu_count, gzip_edge_outputs, include_bootstrap, @@ -1219,16 +1222,17 @@ def benchmark_atera_lr_build_a100_matrix( repeat_id, output_json, ): - """Build the parallel A100 job matrix for second-wave LR methods.""" + """Build the parallel A100 job matrix for second-wave CCI methods.""" payload = build_a100_job_matrix( benchmark_root=benchmark_root, remote_root=remote_root, methods=[item.strip() for item in methods.split(",") if item.strip()], database_mode=database_mode, phase=phase, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, commot_chunks=commot_chunks, + cellagentchat_chunks=cellagentchat_chunks, gpu_count=gpu_count, gzip_edge_outputs=gzip_edge_outputs, include_bootstrap=include_bootstrap, @@ -1241,14 +1245,14 @@ def benchmark_atera_lr_build_a100_matrix( click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("build-a100-sidecar") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("build-a100-sidecar") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--remote-root", default=DEFAULT_A100_REMOTE_ROOT, show_default=True) @click.option("--methods", default="spatialdm,stlearn,giotto,laris,cellphonedb,spatalk,niches,cellnest,cellagentchat,scild", show_default=True) @click.option("--ready-methods", default=None, help="Comma-separated methods whose env bootstrap is already complete. Defaults to --methods.") @click.option("--database-mode", default="common-db", show_default=True) -@click.option("--smoke-max-lr-pairs", type=int, default=25, show_default=True) -@click.option("--pilot-max-lr-pairs", type=int, default=100, show_default=True) +@click.option("--smoke-max-cci-pairs", type=int, default=25, show_default=True) +@click.option("--pilot-max-cci-pairs", type=int, default=100, show_default=True) @click.option("--pilot-n-cells", type=int, default=50000, show_default=True) @click.option("--pilot-seed", type=int, default=1, show_default=True) @click.option("--include-audit/--skip-audit", default=True, show_default=True) @@ -1260,14 +1264,14 @@ def benchmark_atera_lr_build_a100_matrix( @click.option("--gpu-start", type=int, default=3, show_default=True) @click.option("--gzip-edge-outputs/--plain-edge-outputs", default=True, show_default=True) @click.option("--output-json", default=None) -def benchmark_atera_lr_build_a100_sidecar( +def benchmark_atera_cci_build_a100_sidecar( benchmark_root, remote_root, methods, ready_methods, database_mode, - smoke_max_lr_pairs, - pilot_max_lr_pairs, + smoke_max_cci_pairs, + pilot_max_cci_pairs, pilot_n_cells, pilot_seed, include_audit, @@ -1280,15 +1284,15 @@ def benchmark_atera_lr_build_a100_sidecar( gzip_edge_outputs, output_json, ): - """Build a balanced A100 sidecar matrix for already bootstrapped LR methods.""" + """Build a balanced A100 sidecar matrix for already bootstrapped CCI methods.""" payload = build_a100_sidecar_matrix( benchmark_root=benchmark_root, remote_root=remote_root, methods=[item.strip() for item in methods.split(",") if item.strip()], ready_methods=None if not ready_methods else [item.strip() for item in ready_methods.split(",") if item.strip()], database_mode=database_mode, - smoke_max_lr_pairs=smoke_max_lr_pairs, - pilot_max_lr_pairs=pilot_max_lr_pairs, + smoke_max_cci_pairs=smoke_max_cci_pairs, + pilot_max_cci_pairs=pilot_max_cci_pairs, pilot_n_cells=pilot_n_cells, pilot_seed=pilot_seed, include_audit=include_audit, @@ -1306,7 +1310,7 @@ def benchmark_atera_lr_build_a100_sidecar( click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("submit-a100-matrix") +@benchmark_atera_cci_group.command("submit-a100-matrix") @click.option("--matrix-json", required=True, help="A100 job matrix JSON produced by build-a100-matrix.") @click.option("--job-id", "job_ids", multiple=True, help="Optional job id filter.") @click.option("--job-type", "job_types", multiple=True, help="Optional job type filter, e.g. env_bootstrap, env_audit, method_run.") @@ -1314,7 +1318,7 @@ def benchmark_atera_lr_build_a100_sidecar( @click.option("--remote/--local", default=True, show_default=True) @click.option("--host", default=None) @click.option("--user", default=None) -def benchmark_atera_lr_submit_a100_matrix(matrix_json, job_ids, job_types, dry_run, remote, host, user): +def benchmark_atera_cci_submit_a100_matrix(matrix_json, job_ids, job_types, dry_run, remote, host, user): """Submit A100 matrix jobs with remote nohup wrappers.""" payload = submit_a100_matrix( matrix_json=matrix_json, @@ -1328,27 +1332,45 @@ def benchmark_atera_lr_submit_a100_matrix(matrix_json, job_ids, job_types, dry_r click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("monitor-a100-jobs") +@benchmark_atera_cci_group.command("monitor-a100-jobs") @click.option("--matrix-json", required=True, help="A100 job matrix JSON.") @click.option("--benchmark-root", default=None) @click.option("--output-tsv", default=None) -def benchmark_atera_lr_monitor_a100_jobs(matrix_json, benchmark_root, output_tsv): +def benchmark_atera_cci_monitor_a100_jobs(matrix_json, benchmark_root, output_tsv): """Summarize collected status for planned A100 jobs.""" table = monitor_a100_jobs(matrix_json=matrix_json, benchmark_root=benchmark_root, output_tsv=output_tsv) click.echo(table.to_json(orient="records", indent=2)) -@benchmark_atera_lr_group.command("finalize-a100-all") +@benchmark_atera_cci_group.command("finalize-a100-all") @click.option("--benchmark-root", default=None) @click.option("--output-path", default=None) -def benchmark_atera_lr_finalize_a100_all(benchmark_root, output_path): +def benchmark_atera_cci_finalize_a100_all(benchmark_root, output_path): """Aggregate all collected A100 standardized TSV/TSV.GZ outputs.""" payload = finalize_a100_all(benchmark_root=benchmark_root, output_path=output_path) click.echo(json.dumps(payload, indent=2)) -@benchmark_atera_lr_group.command("collect-a100-results") -@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/lr_2026_atera under the repo root.") +@benchmark_atera_cci_group.command("finalize-source-of-truth") +@click.option("--benchmark-root", default=None) +@click.option("--output-prefix", default="source_of_truth_full_common", show_default=True) +@click.option("--pdc-tag", default=None, help="Optional pdc_collected tag to use for PDC backfill outputs.") +@click.option("--commot-chunks", type=int, default=16, show_default=True) +@click.option("--render-report/--skip-report", default=True, show_default=True) +def benchmark_atera_cci_finalize_source_of_truth(benchmark_root, output_prefix, pdc_tag, commot_chunks, render_report): + """Finalize CCI outputs using A100-first, PDC-backfill precedence.""" + payload = finalize_cci_source_of_truth( + benchmark_root=benchmark_root, + output_prefix=output_prefix, + pdc_tag=pdc_tag, + commot_chunks=commot_chunks, + render_report=render_report, + ) + click.echo(json.dumps(payload, indent=2)) + + +@benchmark_atera_cci_group.command("collect-a100-results") +@click.option("--benchmark-root", default=None, help="Optional benchmark root. Defaults to benchmarking/cci_2026_atera under the repo root.") @click.option("--remote-root", default=DEFAULT_A100_REMOTE_ROOT, show_default=True) @click.option("--host", default=None) @click.option("--user", default=None) @@ -1356,7 +1378,7 @@ def benchmark_atera_lr_finalize_a100_all(benchmark_root, output_path): @click.option("--dry-run/--execute", default=True, show_default=True) @click.option("--since-last", is_flag=True, default=False, help="Record that this collection pass should only fetch newly finished outputs when implemented by the transfer backend.") @click.option("--output-json", default=None) -def benchmark_atera_lr_collect_a100_results(benchmark_root, remote_root, host, user, transfer_mode, dry_run, since_last, output_json): +def benchmark_atera_cci_collect_a100_results(benchmark_root, remote_root, host, user, transfer_mode, dry_run, since_last, output_json): """Generate or execute result recovery commands from A100.""" payload = collect_a100_results( benchmark_root=benchmark_root, diff --git a/src/pyXenium/_topology_core.py b/src/pyXenium/_topology_core.py index 044ce04..e4f69ef 100644 --- a/src/pyXenium/_topology_core.py +++ b/src/pyXenium/_topology_core.py @@ -552,10 +552,10 @@ def summarize_expression_by_celltype( return raw, normalized -def normalize_lr_prior(lr_pairs: pd.DataFrame, prior_col: Optional[str]) -> pd.Series: - if prior_col is None or prior_col not in lr_pairs.columns: - return pd.Series(np.ones(len(lr_pairs)), index=lr_pairs.index, name="prior_confidence") - prior = pd.to_numeric(lr_pairs[prior_col], errors="coerce").fillna(0.0).astype(float) +def normalize_interaction_prior(interaction_pairs: pd.DataFrame, prior_col: Optional[str]) -> pd.Series: + if prior_col is None or prior_col not in interaction_pairs.columns: + return pd.Series(np.ones(len(interaction_pairs)), index=interaction_pairs.index, name="prior_confidence") + prior = pd.to_numeric(interaction_pairs[prior_col], errors="coerce").fillna(0.0).astype(float) return normalize_series(prior).rename("prior_confidence") diff --git a/src/pyXenium/analysis/__init__.py b/src/pyXenium/analysis/__init__.py index 442656b..6f91605 100644 --- a/src/pyXenium/analysis/__init__.py +++ b/src/pyXenium/analysis/__init__.py @@ -1,7 +1,7 @@ from __future__ import annotations from pyXenium._compat import deprecated_callable, deprecated_symbol -from pyXenium.ligand_receptor import ligand_receptor_topology_analysis as _ligand_receptor_topology_analysis +from pyXenium.cci import cci_topology_analysis as _cci_topology_analysis from pyXenium.multimodal import ( plot_auc_heatmap as _plot_auc_heatmap, plot_DE_volcano as _plot_DE_volcano, @@ -62,10 +62,10 @@ old_path="pyXenium.analysis.plot_topk_per_cluster", new_path="pyXenium.multimodal.plot_topk_per_cluster", ) -ligand_receptor_topology_analysis = deprecated_callable( - _ligand_receptor_topology_analysis, - old_path="pyXenium.analysis.ligand_receptor_topology_analysis", - new_path="pyXenium.ligand_receptor.ligand_receptor_topology_analysis", +cci_topology_analysis = deprecated_callable( + _cci_topology_analysis, + old_path="pyXenium.analysis.cci_topology_analysis", + new_path="pyXenium.cci.cci_topology_analysis", ) pathway_topology_analysis = deprecated_callable( _pathway_topology_analysis, @@ -109,7 +109,7 @@ def __getattr__(name: str): __all__ = [ "compute_pathway_activity_matrix", "differential", - "ligand_receptor_topology_analysis", + "cci_topology_analysis", "microenv_analysis", "pathway_topology_analysis", "plot_auc_heatmap", diff --git a/src/pyXenium/analysis/ligand_receptor_topology.py b/src/pyXenium/analysis/cci_topology.py similarity index 53% rename from src/pyXenium/analysis/ligand_receptor_topology.py rename to src/pyXenium/analysis/cci_topology.py index cb8ac7f..e60fe85 100644 --- a/src/pyXenium/analysis/ligand_receptor_topology.py +++ b/src/pyXenium/analysis/cci_topology.py @@ -2,17 +2,17 @@ from pyXenium._compat import deprecated_symbol -_PUBLIC_NAMES = {"ligand_receptor_topology_analysis"} +_PUBLIC_NAMES = {"cci_topology_analysis"} def __getattr__(name: str): return deprecated_symbol( name, - target_module="pyXenium.ligand_receptor", + target_module="pyXenium.cci", public_names=_PUBLIC_NAMES, old_namespace=__name__, - new_namespace="pyXenium.ligand_receptor", + new_namespace="pyXenium.cci", ) -__all__ = ["ligand_receptor_topology_analysis"] +__all__ = ["cci_topology_analysis"] diff --git a/src/pyXenium/benchmarking/__init__.py b/src/pyXenium/benchmarking/__init__.py index 7edeb41..e727a39 100644 --- a/src/pyXenium/benchmarking/__init__.py +++ b/src/pyXenium/benchmarking/__init__.py @@ -1,6 +1,6 @@ from __future__ import annotations -from .lr_atera import ( +from .cci_atera import ( ATERA_BENCHMARK_RELATIVE_ROOT, STANDARDIZED_RESULT_COLUMNS, aggregate_standardized_results, @@ -13,35 +13,37 @@ compute_robustness, ensure_layout, load_method_registry, - prepare_atera_lr_benchmark, - render_atera_lr_benchmark_report, + prepare_atera_cci_benchmark, + render_atera_cci_benchmark_report, resolve_layout, run_pyxenium_smoke, score_biological_performance, standardize_result_table, ) -from .lr_adapters import ( +from .cci_adapters import ( SUPPORTED_REAL_ADAPTERS, MethodRunSpec, aggregate_commot_obsp_result, aggregate_liana_bivariate_result, build_method_run_plan, ensure_spatial_connectivities, - flatten_squidpy_ligrec_result, + flatten_squidpy_cci_result, load_adata_from_manifest, load_input_manifest, - read_lr_resource, + read_cci_resource, read_sparse_bundle_as_adata, run_registered_method, run_smoke_core, select_input_source, validate_input_manifest, ) -from .lr_a100 import ( +from .cci_a100 import ( DEFAULT_A100_ALL_METHODS, + A100_AUTHORITATIVE_FULL_METHODS, DEFAULT_A100_METHOD_ORDER, DEFAULT_A100_READONLY_XENIUM_ROOT, DEFAULT_A100_REMOTE_ROOT, + PDC_FULL_BACKFILL_METHODS, build_a100_job_manifest, build_a100_job_matrix, build_a100_resource_summary, @@ -51,9 +53,11 @@ collect_a100_results, execute_a100_stage_plan, finalize_a100_all, + finalize_cci_source_of_truth, monitor_a100_jobs, prepare_a100_bundle, run_a100_plan, + select_cci_source_of_truth_inputs, submit_a100_matrix, summarize_run_status, validate_a100_path_policy, @@ -67,8 +71,10 @@ "STANDARDIZED_RESULT_COLUMNS", "DEFAULT_A100_METHOD_ORDER", "DEFAULT_A100_ALL_METHODS", + "A100_AUTHORITATIVE_FULL_METHODS", "DEFAULT_A100_READONLY_XENIUM_ROOT", "DEFAULT_A100_REMOTE_ROOT", + "PDC_FULL_BACKFILL_METHODS", "aggregate_commot_obsp_result", "aggregate_liana_bivariate_result", "aggregate_standardized_results", @@ -84,6 +90,7 @@ "collect_a100_results", "execute_a100_stage_plan", "finalize_a100_all", + "finalize_cci_source_of_truth", "monitor_a100_jobs", "compute_canonical_recovery", "compute_novelty_support", @@ -92,17 +99,18 @@ "compute_robustness", "ensure_layout", "ensure_spatial_connectivities", - "flatten_squidpy_ligrec_result", + "flatten_squidpy_cci_result", "load_adata_from_manifest", "load_input_manifest", "load_method_registry", - "prepare_atera_lr_benchmark", + "prepare_atera_cci_benchmark", "prepare_a100_bundle", - "read_lr_resource", + "read_cci_resource", "read_sparse_bundle_as_adata", - "render_atera_lr_benchmark_report", + "render_atera_cci_benchmark_report", "resolve_layout", "run_a100_plan", + "select_cci_source_of_truth_inputs", "submit_a100_matrix", "run_registered_method", "run_pyxenium_smoke", diff --git a/src/pyXenium/benchmarking/lr_a100.py b/src/pyXenium/benchmarking/cci_a100.py similarity index 72% rename from src/pyXenium/benchmarking/lr_a100.py rename to src/pyXenium/benchmarking/cci_a100.py index 01dfc65..2d1aba8 100644 --- a/src/pyXenium/benchmarking/lr_a100.py +++ b/src/pyXenium/benchmarking/cci_a100.py @@ -14,11 +14,11 @@ import pandas as pd -from .lr_atera import ATERA_BENCHMARK_RELATIVE_ROOT, BenchmarkLayout, load_method_registry, resolve_layout -from .lr_adapters import SUPPORTED_REAL_ADAPTERS, load_input_manifest, validate_input_manifest +from .cci_atera import ATERA_BENCHMARK_RELATIVE_ROOT, BenchmarkLayout, load_method_registry, resolve_layout +from .cci_adapters import SUPPORTED_REAL_ADAPTERS, load_input_manifest, validate_input_manifest -DEFAULT_A100_REMOTE_ROOT = "/data/taobo.hu/pyxenium_lr_benchmark_2026-04" +DEFAULT_A100_REMOTE_ROOT = "/data/taobo.hu/pyxenium_cci_benchmark_2026-04" DEFAULT_A100_READONLY_XENIUM_ROOT = "/mnt/taobo.hu/long/10X_datasets/Xenium/Atera/WTA_Preview_FFPE_Breast_Cancer_outs" DEFAULT_A100_METHOD_ORDER = ("pyxenium", "squidpy", "liana", "commot", "cellchat") DEFAULT_A100_ALL_METHODS = ( @@ -38,7 +38,31 @@ "cellagentchat", "scild", ) +A100_AUTHORITATIVE_FULL_METHODS = ( + "pyxenium", + "squidpy", + "liana", + "spatialdm", + "stlearn", + "cellphonedb", + "laris", +) +PDC_FULL_BACKFILL_METHODS = tuple(method for method in DEFAULT_A100_ALL_METHODS if method not in A100_AUTHORITATIVE_FULL_METHODS) A100_GPU_METHODS = {"cellnest", "cellagentchat", "scild"} +A100_SOURCE_CHECKOUTS = { + "cellnest": { + "repo": "https://github.com/schwartzlab-methods/CellNEST.git", + "commit": "2737fa8f54952b4b35a540f6070655a69f2c4999", + }, + "cellagentchat": { + "repo": "https://github.com/mcgilldinglab/CellAgentChat.git", + "commit": "37e51980cb9ba87684993d8bdae26feac8806bae", + }, + "scild": { + "repo": "https://github.com/jiatingyu-amss/SCILD.git", + "commit": "683515043df1878f3069c4dd5f887abb5c8976bd", + }, +} A100_R_HEAVY_METHODS = {"cellchat", "spatalk", "niches", "giotto"} A100_PYTHON_AUDIT_MODULES = { "commot": ("commot",), @@ -56,6 +80,7 @@ "repo", "configs", "envs", + "external_src", "scripts", "runners", "data", @@ -77,6 +102,16 @@ def _write_json(path: str | Path, payload: Mapping[str, Any]) -> Path: return path +def _read_json(path: str | Path) -> dict[str, Any]: + path = Path(path) + if not path.exists(): + return {} + try: + return json.loads(path.read_text(encoding="utf-8")) + except json.JSONDecodeError: + return {"status": "unreadable", "error": f"Could not parse {path}"} + + def _safe_slug(value: str) -> str: return "".join(ch if ch.isalnum() else "_" for ch in str(value)).strip("_").lower() @@ -120,6 +155,26 @@ def _join_command(parts: Sequence[str | Path | int]) -> str: return " ".join(_q(str(part)) for part in parts) +def _a100_source_checkout_command(method: str, remote_root: str | Path) -> str: + checkout = A100_SOURCE_CHECKOUTS.get(str(method).lower()) + if not checkout: + return "" + repo = str(checkout["repo"]) + commit = str(checkout["commit"]) + external_root = _remote_path(remote_root, "external_src") + src = _remote_path(external_root, method) + ok_message = f"source_checkout_ok {method} already at {commit}" + return ( + f"mkdir -p {_q(external_root)} && " + f"if [ ! -d {_q(src)}/.git ]; then rm -rf {_q(src)} && git clone {_q(repo)} {_q(src)}; fi && " + f'current_commit="$(git -C {_q(src)} rev-parse HEAD 2>/dev/null || true)"; ' + f"if [ \"$current_commit\" = {_q(commit)} ]; then echo {_q(ok_message)}; " + f"else if ! git -C {_q(src)} cat-file -e {_q(commit + '^{commit}')} 2>/dev/null; " + f"then git -C {_q(src)} fetch --all --tags --prune; fi; " + f"git -C {_q(src)} checkout {_q(commit)}; fi" + ) + + def _remote_target(host: str | None, user: str | None) -> str: return f"{user}@{host}" if host and user else "@" @@ -211,7 +266,7 @@ def _prepare_full_bundle_command( "conda", "run", "--name", - "pyx-lr-prep", + "pyx-cci-prep", "python", _remote_path(remote_root, "scripts", "prepare_data.py"), "--xenium-root", @@ -232,7 +287,7 @@ def _prepare_full_bundle_command( _join_command(parts), remote_root=remote_root, job_id=job_id, - env_name="pyx-lr-prep", + env_name="pyx-cci-prep", ) @@ -244,7 +299,7 @@ def _method_run_command( phase: str, database_mode: str, run_group: str, - max_lr_pairs: int | None, + max_cci_pairs: int | None, n_perms: int, input_manifest: str | Path | None = None, repeat_id: str | None = None, @@ -266,7 +321,7 @@ def _method_run_command( input_manifest = str(input_manifest) if input_manifest is not None else _remote_path(remote_root, "data", "input_manifest.json") python_contract_runner = method_info.get("language") != "r" if method_info.get("language") == "r": - runner_name = "run_cellchat.R" if method == "cellchat" else "run_external_lr_method.R" + runner_name = "run_cellchat.R" if method == "cellchat" else "run_external_cci_method.R" parts = [ "conda", "run", @@ -308,8 +363,8 @@ def _method_run_command( "--n-perms", str(n_perms), ] - if max_lr_pairs is not None: - parts.extend(["--max-lr-pairs", str(max_lr_pairs)]) + if max_cci_pairs is not None: + parts.extend(["--max-cci-pairs", str(max_cci_pairs)]) if python_contract_runner: if chunk_id is not None: parts.extend(["--chunk-id", str(chunk_id)]) @@ -322,9 +377,20 @@ def _method_run_command( parts.extend(["--job-id", str(job_id)]) if gzip_standardized: parts.append("--gzip-standardized") + inner_command = _join_command(parts) + if method == "cellagentchat": + inner_command = ( + 'export CELLAGENTCHAT_FEATURE_SELECTION="${CELLAGENTCHAT_FEATURE_SELECTION:-0}" && ' + 'export CELLAGENTCHAT_EPOCHS="${CELLAGENTCHAT_EPOCHS:-10}" && ' + 'export CELLAGENTCHAT_MAX_STEPS="${CELLAGENTCHAT_MAX_STEPS:-1}" && ' + f"{inner_command}" + ) + source_setup = _a100_source_checkout_command(method, remote_root) + if source_setup: + inner_command = f"{source_setup} && {inner_command}" profile = _resource_profile(method) return _wrap_a100_job( - _join_command(parts), + inner_command, remote_root=remote_root, job_id=job_id, env_name=env_name, @@ -334,6 +400,95 @@ def _method_run_command( ) +def _cellagentchat_aggregate_command( + *, + remote_root: str | Path, + run_group: str, + database_mode: str, + num_chunks: int, + job_id: str, +) -> tuple[str, str]: + output_dir = _remote_path(remote_root, "runs", run_group, "cellagentchat") + python_code = f""" +import json +from pathlib import Path + +import pandas as pd + +from pyXenium.benchmarking.cci_atera import STANDARDIZED_RESULT_COLUMNS, _resolve_ordered_rank + +root = Path({output_dir!r}) +num_chunks = {int(num_chunks)} +paths = [] +missing = [] +for idx in range(num_chunks): + chunk_dir = root / f"chunk_{{idx:03d}}_of_{{num_chunks:03d}}" + candidates = [ + chunk_dir / "cellagentchat_standardized.tsv.gz", + chunk_dir / "cellagentchat_standardized.tsv", + ] + path = next((candidate for candidate in candidates if candidate.exists()), None) + if path is None: + missing.append(str(chunk_dir)) + else: + paths.append(path) +if missing: + raise SystemExit("missing cellagentchat chunk standardized outputs: " + ", ".join(missing)) + +frames = [] +extra_columns = [] +for path in paths: + table = pd.read_csv(path, sep=chr(9), compression="infer") + missing_columns = [column for column in STANDARDIZED_RESULT_COLUMNS if column not in table.columns] + if missing_columns: + raise SystemExit(f"standardized chunk {{path}} is missing columns: {{missing_columns}}") + for column in table.columns: + if column not in STANDARDIZED_RESULT_COLUMNS and column not in extra_columns: + extra_columns.append(column) + frames.append(table.copy()) +if not frames: + raise SystemExit("no cellagentchat chunk tables to aggregate") + +ordered_columns = STANDARDIZED_RESULT_COLUMNS + extra_columns +combined = pd.concat(frames, ignore_index=True).reindex(columns=ordered_columns) +if combined.empty: + raise SystemExit("cellagentchat chunk aggregation produced an empty table") +scores = pd.to_numeric(combined["score_raw"], errors="coerce") +fill = scores.min(skipna=True) if scores.notna().any() else 0.0 +scores = scores.fillna(fill) +pvalues = pd.to_numeric(combined["fdr_or_pvalue"], errors="coerce") +rank, rank_fraction = _resolve_ordered_rank(scores, pvalues) +combined["rank_within_method"] = rank.astype(float) +combined["rank_fraction"] = rank_fraction.astype(float) +combined["score_std"] = rank_fraction.astype(float) +combined = combined.loc[:, ordered_columns].sort_values("rank_within_method").reset_index(drop=True) +root.mkdir(parents=True, exist_ok=True) +output = root / "cellagentchat_standardized.tsv.gz" +combined.to_csv(output, sep=chr(9), index=False, compression="gzip") +summary = {{ + "status": "success", + "method": "cellagentchat", + "phase": "full", + "database_mode": {database_mode!r}, + "num_chunks": num_chunks, + "chunk_standardized_tsvs": [str(path) for path in paths], + "standardized_tsv": str(output), + "n_rows": int(len(combined)), +}} +(root / "run_summary.json").write_text(json.dumps(summary, indent=2) + chr(10), encoding="utf-8") +print(json.dumps(summary, indent=2)) +""".strip() + inner = _join_command(["conda", "run", "--name", "pyx-cci-cellagentchat", "python", "-c", python_code]) + return _wrap_a100_job( + inner, + remote_root=remote_root, + job_id=job_id, + env_name="pyx-cci-cellagentchat", + omp_threads=4, + mkl_threads=4, + ) + + def _audit_command(method: str, method_info: Mapping[str, Any], remote_root: str | Path, *, job_id: str) -> tuple[str, str]: env_name = str(method_info.get("env_name", "")) if method_info.get("language") == "r": @@ -592,7 +747,7 @@ def build_a100_job_manifest( methods: Sequence[str] = DEFAULT_A100_METHOD_ORDER, database_mode: str = "common-db", phase: str = "full", - max_lr_pairs: int | None = None, + max_cci_pairs: int | None = None, n_perms: int = 100, include_audit: bool = True, include_prepare: bool = True, @@ -622,7 +777,7 @@ def build_a100_job_manifest( "method": "prep", "phase": "prepare", "database_mode": database_mode, - "env_name": "pyx-lr-prep", + "env_name": "pyx-cci-prep", "command": prepare_command, "input_root": str(remote_xenium_root), "input_manifest": _remote_path(remote_root, "data", "input_manifest.json"), @@ -679,7 +834,7 @@ def build_a100_job_manifest( phase=phase, database_mode=database_mode, run_group=run_group, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, repeat_id=repeat_id, job_id=job_id, @@ -716,7 +871,7 @@ def build_a100_job_manifest( "phase": phase, "database_mode": database_mode, "methods": list(methods), - "max_lr_pairs": max_lr_pairs, + "max_cci_pairs": max_cci_pairs, "n_perms": n_perms, "run_group": run_group, "resource_limits": {"max_memory_gb": 64, "max_runtime_seconds": 6 * 60 * 60}, @@ -735,7 +890,7 @@ def prepare_a100_bundle( methods: Sequence[str] = DEFAULT_A100_METHOD_ORDER, database_mode: str = "common-db", phase: str = "full", - max_lr_pairs: int | None = None, + max_cci_pairs: int | None = None, n_perms: int = 100, require_full: bool = True, include_prepare: bool = True, @@ -767,7 +922,7 @@ def prepare_a100_bundle( methods=methods, database_mode=database_mode, phase=phase, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, include_prepare=include_prepare, smoke_n_cells=smoke_n_cells, @@ -1097,9 +1252,10 @@ def build_a100_job_matrix( methods: Sequence[str] = DEFAULT_A100_ALL_METHODS, database_mode: str = "common-db", phase: str = "smoke", - max_lr_pairs: int | None = None, + max_cci_pairs: int | None = None, n_perms: int = 100, commot_chunks: int = 16, + cellagentchat_chunks: int = 16, gpu_count: int = 8, gzip_edge_outputs: bool = True, include_bootstrap: bool = False, @@ -1172,6 +1328,9 @@ def build_a100_job_matrix( if method == "commot" and phase == "full" and commot_chunks > 1: chunk_ids = list(range(int(commot_chunks))) num_chunks = int(commot_chunks) + elif method == "cellagentchat" and phase == "full" and cellagentchat_chunks > 1: + chunk_ids = list(range(int(cellagentchat_chunks))) + num_chunks = int(cellagentchat_chunks) else: chunk_ids = [None] num_chunks = None @@ -1191,7 +1350,7 @@ def build_a100_job_matrix( phase=phase, database_mode=database_mode, run_group=run_group, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, repeat_id=repeat_id, job_id=job_id, @@ -1226,6 +1385,49 @@ def build_a100_job_matrix( **profile, } ) + if method == "cellagentchat" and phase == "full" and num_chunks and num_chunks > 1: + repeat_suffix = "" if repeat_id is None else f"_{_safe_slug(repeat_id)}" + aggregate_id = f"{phase}_{_safe_slug(database_mode)}{repeat_suffix}_cellagentchat_aggregate" + dependencies = [ + f"{phase}_{_safe_slug(database_mode)}{repeat_suffix}_cellagentchat_chunk_{idx:03d}_of_{num_chunks:03d}" + for idx in range(int(num_chunks)) + ] + aggregate_command, aggregate_resource_log = _cellagentchat_aggregate_command( + remote_root=remote_root, + run_group=run_group, + database_mode=database_mode, + num_chunks=int(num_chunks), + job_id=aggregate_id, + ) + jobs.append( + { + "job_id": aggregate_id, + "job_type": "method_aggregate", + "method": "cellagentchat", + "phase": phase, + "database_mode": database_mode, + "repeat_id": repeat_id, + "chunk_id": None, + "num_chunks": int(num_chunks), + "gpu_id": None, + "env_name": method_info.get("env_name"), + "command": aggregate_command, + "input_manifest": _remote_path(remote_root, "data", "input_manifest.json"), + "output_dir": _remote_path(remote_root, "runs", run_group, "cellagentchat"), + "stdout": _remote_path(remote_root, "logs", f"{aggregate_id}.stdout.log"), + "stderr": _remote_path(remote_root, "logs", f"{aggregate_id}.stderr.log"), + "resource_log": aggregate_resource_log, + "dependencies": dependencies, + "status": "planned", + "runtime_seconds": None, + "peak_memory_gb": None, + "exit_code": None, + "gpu_required": False, + "max_parallel_group": "aggregate", + "omp_threads": 4, + "mkl_threads": 4, + } + ) payload = { "kind": "a100_job_matrix", @@ -1234,7 +1436,7 @@ def build_a100_job_matrix( "database_mode": database_mode, "methods": [str(item).strip().lower() for item in methods if str(item).strip()], "run_group": run_group, - "max_lr_pairs": max_lr_pairs, + "max_cci_pairs": max_cci_pairs, "n_perms": n_perms, "include_bootstrap": include_bootstrap, "include_audit": include_audit, @@ -1244,7 +1446,9 @@ def build_a100_job_matrix( "max_r_heavy_parallel": 2, "max_cpu_heavy_parallel": 3, "max_commot_chunks_parallel": 4, + "max_cellagentchat_chunks_parallel": int(min(max(1, int(gpu_count)), max(1, int(cellagentchat_chunks)))), }, + "cellagentchat_chunks": int(cellagentchat_chunks), "jobs": jobs, } payload["path_policy"] = validate_a100_path_policy(payload, remote_root=remote_root, readonly_xenium_root=DEFAULT_A100_READONLY_XENIUM_ROOT) @@ -1273,8 +1477,8 @@ def _prepare_pilot_bundle_command( print(json.dumps({{"status": "exists", "input_manifest": str(pilot_manifest_path)}})) raise SystemExit(0) -from pyXenium.benchmarking.lr_adapters import read_sparse_bundle_as_adata -from pyXenium.benchmarking.lr_atera import _bundle_fingerprints, _write_sparse_bundle, stratified_subset +from pyXenium.benchmarking.cci_adapters import read_sparse_bundle_as_adata +from pyXenium.benchmarking.cci_atera import _bundle_fingerprints, _write_sparse_bundle, stratified_subset manifest = json.loads(input_manifest_path.read_text(encoding="utf-8")) full_bundle = manifest.get("full_bundle") or {{}} @@ -1294,16 +1498,16 @@ def _prepare_pilot_bundle_command( pilot_manifest["pilot_source_manifest"] = str(input_manifest_path) pilot_manifest["pilot_n_cells"] = int(pilot.n_obs) pilot_manifest["pilot_seed"] = {int(seed)} -pilot_manifest["pilot_note"] = "50k stratified pilot bundle used for A100 LR method runtime projection." +pilot_manifest["pilot_note"] = "50k stratified pilot bundle used for A100 CCI method runtime projection." pilot_manifest_path.write_text(json.dumps(pilot_manifest, indent=2, default=str) + chr(10), encoding="utf-8") print(json.dumps({{"status": "created", "input_manifest": str(pilot_manifest_path), "n_cells": int(pilot.n_obs)}})) """.strip() - inner = _join_command(["conda", "run", "--name", "pyx-lr-prep", "python", "-c", python_code]) + inner = _join_command(["conda", "run", "--name", "pyx-cci-prep", "python", "-c", python_code]) return _wrap_a100_job( inner, remote_root=remote_root, job_id=job_id, - env_name="pyx-lr-prep", + env_name="pyx-cci-prep", ) @@ -1314,8 +1518,8 @@ def build_a100_sidecar_matrix( methods: Sequence[str] = DEFAULT_A100_ALL_METHODS, ready_methods: Sequence[str] | None = None, database_mode: str = "common-db", - smoke_max_lr_pairs: int | None = 25, - pilot_max_lr_pairs: int | None = 100, + smoke_max_cci_pairs: int | None = 25, + pilot_max_cci_pairs: int | None = 100, pilot_n_cells: int = 50_000, pilot_seed: int = 1, include_audit: bool = True, @@ -1350,7 +1554,7 @@ def build_a100_sidecar_matrix( "method": "data", "phase": "pilot_prep", "database_mode": database_mode, - "env_name": "pyx-lr-prep", + "env_name": "pyx-cci-prep", "command": command, "input_manifest": _remote_path(remote_root, "data", "input_manifest.json"), "output_dir": _remote_path(remote_root, "data", "pilot50k"), @@ -1406,7 +1610,7 @@ def build_a100_sidecar_matrix( phase="smoke", database_mode=database_mode, run_group="smoke_sidecar_common", - max_lr_pairs=smoke_max_lr_pairs, + max_cci_pairs=smoke_max_cci_pairs, n_perms=100, job_id=job_id, bounded_mode="sidecar_smoke_20k", @@ -1452,11 +1656,11 @@ def build_a100_sidecar_matrix( phase="full", database_mode=database_mode, run_group="pilot50k_common", - max_lr_pairs=pilot_max_lr_pairs, + max_cci_pairs=pilot_max_cci_pairs, n_perms=100, input_manifest=_remote_path(remote_root, "data", "pilot50k", "input_manifest.json"), job_id=job_id, - bounded_mode=f"pilot50k_{pilot_max_lr_pairs or 'all'}lr", + bounded_mode=f"pilot50k_{pilot_max_cci_pairs or 'all'}cci", gpu_id=gpu_id, gzip_standardized=gzip_edge_outputs and method in {"commot", "spatialdm", "stlearn", "laris", "cellnest", "cellagentchat", "scild", "niches", "spatalk"}, @@ -1468,7 +1672,7 @@ def build_a100_sidecar_matrix( "method": method, "phase": "full", "database_mode": database_mode, - "bounded_mode": f"pilot50k_{pilot_max_lr_pairs or 'all'}lr", + "bounded_mode": f"pilot50k_{pilot_max_cci_pairs or 'all'}cci", "gpu_id": gpu_id, "env_name": method_info.get("env_name"), "command": command, @@ -1493,8 +1697,8 @@ def build_a100_sidecar_matrix( "database_mode": database_mode, "smoke_run_group": "smoke_sidecar_common", "pilot_run_group": "pilot50k_common", - "smoke_max_lr_pairs": smoke_max_lr_pairs, - "pilot_max_lr_pairs": pilot_max_lr_pairs, + "smoke_max_cci_pairs": smoke_max_cci_pairs, + "pilot_max_cci_pairs": pilot_max_cci_pairs, "pilot_n_cells": int(pilot_n_cells), "pilot_seed": int(pilot_seed), "completed_job_ids": sorted(set(completed_job_ids or [])), @@ -1612,12 +1816,385 @@ def monitor_a100_jobs( return table +FAILED_RUN_STATUSES = { + "failed", + "failed_resource_oom", + "submit_failed", + "skipped_missing_dependency", + "unreadable", +} + + +def _standardized_outputs(run_dir: Path, *, recursive: bool = False) -> list[Path]: + patterns = ("*standardized.tsv", "*standardized.tsv.gz") + outputs: list[Path] = [] + for pattern in patterns: + iterator = run_dir.rglob(pattern) if recursive else run_dir.glob(pattern) + outputs.extend(path for path in iterator if path.is_file()) + return sorted(set(outputs)) + + +def _run_summary_status(run_dir: Path) -> str: + summary = _read_json(run_dir / "run_summary.json") + status = str(summary.get("status") or "").strip().lower() + if not status: + return "standardized_present" if _standardized_outputs(run_dir) else "missing_summary" + return status + + +def _run_allows_standardized(run_dir: Path) -> bool: + status = _run_summary_status(run_dir) + return status not in FAILED_RUN_STATUSES + + +def _latest_record(records: list[dict[str, Any]]) -> dict[str, Any] | None: + if not records: + return None + return max(records, key=lambda row: (float(row.get("mtime") or 0.0), str(row.get("path") or ""))) + + +def _direct_method_records( + *, + run_roots: Sequence[Path], + method: str, + platform_name: str, + source_label_prefix: str, +) -> list[dict[str, Any]]: + records: list[dict[str, Any]] = [] + for root in run_roots: + method_dir = root / method + if not method_dir.exists() or not _run_allows_standardized(method_dir): + continue + for path in _standardized_outputs(method_dir): + records.append( + { + "method": method, + "platform": platform_name, + "source_label": source_label_prefix, + "path": str(path), + "run_dir": str(method_dir), + "status": _run_summary_status(method_dir), + "chunk_id": None, + "num_chunks": None, + "mtime": path.stat().st_mtime, + } + ) + return records + + +def _pdc_full_roots(layout: BenchmarkLayout, pdc_tag: str | None = None) -> list[tuple[str, Path]]: + collected = layout.root / "pdc_collected" + if not collected.exists(): + return [] + tags = [collected / pdc_tag] if pdc_tag else sorted(path for path in collected.iterdir() if path.is_dir()) + roots: list[tuple[str, Path]] = [] + for tag_dir in tags: + run_root = tag_dir / "runs" / "full_common" + if run_root.exists(): + roots.append((tag_dir.name, run_root)) + return roots + + +def _pdc_direct_method_record(layout: BenchmarkLayout, method: str, *, pdc_tag: str | None) -> dict[str, Any] | None: + records: list[dict[str, Any]] = [] + for tag, run_root in _pdc_full_roots(layout, pdc_tag=pdc_tag): + records.extend( + _direct_method_records( + run_roots=[run_root], + method=method, + platform_name="pdc", + source_label_prefix=f"pdc:{tag}", + ) + ) + return _latest_record(records) + + +def _chunk_number_from_dir(path: Path) -> int | None: + name = path.name + if not name.startswith("chunk_") or "_of_" not in name: + return None + value = name.split("_of_", 1)[0].replace("chunk_", "") + try: + return int(value) + except ValueError: + return None + + +def _pdc_commot_chunk_records(layout: BenchmarkLayout, *, pdc_tag: str | None, expected_chunks: int) -> tuple[list[dict[str, Any]], dict[str, Any] | None]: + best: list[dict[str, Any]] = [] + best_issue: dict[str, Any] | None = None + for tag, run_root in _pdc_full_roots(layout, pdc_tag=pdc_tag): + commot_root = run_root / "commot" + if not commot_root.exists(): + continue + paths = _standardized_outputs(commot_root, recursive=True) + by_chunk: dict[int, Path] = {} + blocked_chunks: list[int] = [] + for path in paths: + chunk_id = _chunk_number_from_dir(path.parent) + if chunk_id is None: + continue + if not _run_allows_standardized(path.parent): + blocked_chunks.append(chunk_id) + continue + existing = by_chunk.get(chunk_id) + if existing is None or path.stat().st_mtime > existing.stat().st_mtime: + by_chunk[chunk_id] = path + missing = [idx for idx in range(int(expected_chunks)) if idx not in by_chunk] + if missing or blocked_chunks: + best_issue = { + "method": "commot", + "platform": "pdc", + "source_label": f"pdc:{tag}", + "expected_chunks": int(expected_chunks), + "observed_chunks": sorted(by_chunk), + "missing_chunks": missing, + "blocked_chunks": sorted(set(blocked_chunks)), + } + continue + records = [ + { + "method": "commot", + "platform": "pdc", + "source_label": f"pdc:{tag}", + "path": str(by_chunk[idx]), + "run_dir": str(by_chunk[idx].parent), + "status": _run_summary_status(by_chunk[idx].parent), + "chunk_id": idx, + "num_chunks": int(expected_chunks), + "mtime": by_chunk[idx].stat().st_mtime, + } + for idx in range(int(expected_chunks)) + ] + if not best or max(row["mtime"] for row in records) > max(row["mtime"] for row in best): + best = records + best_issue = None + return best, best_issue + + +def _pdc_failure_cards(layout: BenchmarkLayout, method: str, *, pdc_tag: str | None) -> list[str]: + cards: list[str] = [] + for _, run_root in _pdc_full_roots(layout, pdc_tag=pdc_tag): + method_root = run_root / method + if method_root.exists(): + cards.extend(str(path) for path in sorted(method_root.rglob("method_card.md")) if path.is_file()) + return cards + + +def select_cci_source_of_truth_inputs( + *, + benchmark_root: str | Path | None = None, + a100_methods: Sequence[str] = A100_AUTHORITATIVE_FULL_METHODS, + pdc_methods: Sequence[str] = PDC_FULL_BACKFILL_METHODS, + pdc_tag: str | None = None, + commot_chunks: int = 16, +) -> dict[str, Any]: + layout = resolve_layout(relative_root=benchmark_root or ATERA_BENCHMARK_RELATIVE_ROOT) + a100_full = layout.runs_dir / "a100_collected" / "full_common" + selected: list[dict[str, Any]] = [] + issues: list[dict[str, Any]] = [] + selected_methods: set[str] = set() + + for method in [str(item).strip().lower() for item in a100_methods if str(item).strip()]: + record = _latest_record( + _direct_method_records( + run_roots=[a100_full], + method=method, + platform_name="a100", + source_label_prefix="a100:full_common", + ) + ) + if record is None: + issues.append({"method": method, "platform": "a100", "status": "missing_authoritative_full"}) + continue + selected.append(record) + selected_methods.add(method) + + for method in [str(item).strip().lower() for item in pdc_methods if str(item).strip()]: + if method in selected_methods: + continue + if method == "commot": + records, issue = _pdc_commot_chunk_records(layout, pdc_tag=pdc_tag, expected_chunks=commot_chunks) + if records: + selected.extend(records) + selected_methods.add(method) + elif issue: + issue["failure_cards"] = _pdc_failure_cards(layout, method, pdc_tag=pdc_tag) + issues.append(issue) + else: + issues.append( + { + "method": method, + "platform": "pdc", + "status": "missing_full_chunks", + "expected_chunks": int(commot_chunks), + "failure_cards": _pdc_failure_cards(layout, method, pdc_tag=pdc_tag), + } + ) + continue + record = _pdc_direct_method_record(layout, method, pdc_tag=pdc_tag) + if record is None: + issues.append( + { + "method": method, + "platform": "pdc", + "status": "missing_full_standardized", + "failure_cards": _pdc_failure_cards(layout, method, pdc_tag=pdc_tag), + } + ) + continue + selected.append(record) + selected_methods.add(method) + + selected = sorted(selected, key=lambda row: (str(row["method"]), row.get("chunk_id") is not None, row.get("chunk_id") or -1)) + return { + "selected": selected, + "issues": issues, + "a100_authoritative_full_methods": [str(item).strip().lower() for item in a100_methods if str(item).strip()], + "pdc_full_backfill_methods": [str(item).strip().lower() for item in pdc_methods if str(item).strip()], + "selected_methods": sorted(selected_methods), + "input_paths": [row["path"] for row in selected], + "commot_chunks": int(commot_chunks), + "pdc_tag": pdc_tag, + } + + +def _schema_validation(result_paths: Sequence[str | Path], combined: pd.DataFrame) -> dict[str, Any]: + from .cci_atera import STANDARDIZED_RESULT_COLUMNS + + missing_by_file: dict[str, list[str]] = {} + for path_value in result_paths: + path = Path(path_value) + header = pd.read_csv(path, sep="\t", nrows=0, compression="infer") + missing = [column for column in STANDARDIZED_RESULT_COLUMNS if column not in header.columns] + if missing: + missing_by_file[str(path)] = missing + return { + "status": "passed" if not missing_by_file else "failed", + "n_inputs": len(result_paths), + "n_rows": int(len(combined)), + "n_methods": int(combined["method"].nunique()) if not combined.empty and "method" in combined else 0, + "missing_columns_by_file": missing_by_file, + "required_columns": STANDARDIZED_RESULT_COLUMNS, + } + + +def finalize_cci_source_of_truth( + *, + benchmark_root: str | Path | None = None, + output_prefix: str = "source_of_truth_full_common", + pdc_tag: str | None = None, + commot_chunks: int = 16, + render_report: bool = True, +) -> dict[str, Any]: + from .cci_atera import ( + aggregate_standardized_results, + build_canonical_rank_matrix, + compute_canonical_recovery, + compute_novelty_support, + compute_pathway_relevance, + compute_robustness, + compute_spatial_coherence, + render_atera_cci_benchmark_report, + score_biological_performance, + ) + + layout = resolve_layout(relative_root=benchmark_root or ATERA_BENCHMARK_RELATIVE_ROOT) + selection = select_cci_source_of_truth_inputs( + benchmark_root=layout.root, + pdc_tag=pdc_tag, + commot_chunks=commot_chunks, + ) + input_paths = [Path(path) for path in selection["input_paths"]] + combined_path = layout.results_dir / f"{output_prefix}_combined.tsv" + combined = aggregate_standardized_results(input_paths, output_path=combined_path) if input_paths else pd.DataFrame() + validation = _schema_validation(input_paths, combined) if input_paths else { + "status": "empty", + "n_inputs": 0, + "n_rows": 0, + "n_methods": 0, + "missing_columns_by_file": {}, + "required_columns": [], + } + + inputs_path = layout.results_dir / f"{output_prefix}_inputs.tsv" + pd.DataFrame(selection["selected"]).drop(columns=["mtime"], errors="ignore").to_csv(inputs_path, sep="\t", index=False) + validation_path = layout.results_dir / f"{output_prefix}_schema_validation.json" + _write_json(validation_path, validation) + + outputs: dict[str, str] = { + "combined_results": str(combined_path), + "inputs": str(inputs_path), + "schema_validation": str(validation_path), + } + if render_report and not combined.empty and (layout.config_dir / "canonical_axes.yaml").exists() and (layout.config_dir / "pathways.yaml").exists(): + canonical_detail, canonical_summary = compute_canonical_recovery(combined, canonical_axes=layout.config_dir / "canonical_axes.yaml") + pathway_detail, pathway_summary = compute_pathway_relevance(combined, pathway_config=layout.config_dir / "pathways.yaml") + spatial_summary = compute_spatial_coherence(combined) + novelty_detail, novelty_summary = compute_novelty_support(combined) + robustness_summary = compute_robustness(combined) + biology_summary = score_biological_performance( + canonical_summary=canonical_summary, + pathway_summary=pathway_summary, + spatial_summary=spatial_summary, + robustness_summary=robustness_summary, + novelty_summary=novelty_summary, + ) + rank_matrix = build_canonical_rank_matrix(canonical_detail) + run_status = pd.DataFrame(selection["selected"]).drop(columns=["mtime"], errors="ignore") + table_outputs = { + "canonical_detail": (layout.results_dir / f"{output_prefix}_canonical_detail.tsv", canonical_detail), + "canonical_summary": (layout.results_dir / f"{output_prefix}_canonical_summary.tsv", canonical_summary), + "canonical_rank_matrix": (layout.results_dir / f"{output_prefix}_canonical_rank_matrix.tsv", rank_matrix), + "pathway_detail": (layout.results_dir / f"{output_prefix}_pathway_detail.tsv", pathway_detail), + "pathway_summary": (layout.results_dir / f"{output_prefix}_pathway_summary.tsv", pathway_summary), + "spatial_summary": (layout.results_dir / f"{output_prefix}_spatial_coherence.tsv", spatial_summary), + "novelty_detail": (layout.results_dir / f"{output_prefix}_novelty_top.tsv", novelty_detail), + "novelty_summary": (layout.results_dir / f"{output_prefix}_novelty_summary.tsv", novelty_summary), + "robustness_summary": (layout.results_dir / f"{output_prefix}_robustness_summary.tsv", robustness_summary), + "biology_scoreboard": (layout.results_dir / f"{output_prefix}_biology_scoreboard.tsv", biology_summary), + "engineering_scoreboard": (layout.results_dir / f"{output_prefix}_engineering_scoreboard.tsv", run_status), + } + for key, (path, table) in table_outputs.items(): + path.parent.mkdir(parents=True, exist_ok=True) + table.to_csv(path, sep="\t", index=False) + outputs[key] = str(path) + report = render_atera_cci_benchmark_report( + combined_results=combined, + canonical_summary=canonical_summary, + pathway_summary=pathway_summary, + biology_summary=biology_summary, + benchmark_root=layout.root, + run_status=run_status, + engineering_summary=run_status, + canonical_detail=canonical_detail, + a100_resource_summary=run_status[run_status["platform"] == "a100"] if "platform" in run_status else run_status, + ) + report_path = layout.reports_dir / f"{output_prefix}_report.md" + report_path.parent.mkdir(parents=True, exist_ok=True) + report_path.write_text(report, encoding="utf-8") + outputs["report"] = str(report_path) + + payload = { + "kind": "cci_source_of_truth_finalize", + "benchmark_root": str(layout.root), + "n_rows": int(len(combined)), + "n_methods": int(combined["method"].nunique()) if not combined.empty and "method" in combined.columns else 0, + "methods": sorted(combined["method"].dropna().unique().tolist()) if not combined.empty and "method" in combined.columns else [], + "selection": selection, + "validation": validation, + "outputs": outputs, + } + _write_json(layout.results_dir / f"{output_prefix}_finalize_summary.json", payload) + return payload + + def finalize_a100_all( *, benchmark_root: str | Path | None = None, output_path: str | Path | None = None, ) -> dict[str, Any]: - from .lr_atera import aggregate_standardized_results + from .cci_atera import aggregate_standardized_results layout = resolve_layout(relative_root=benchmark_root or ATERA_BENCHMARK_RELATIVE_ROOT) discovered = sorted( diff --git a/src/pyXenium/benchmarking/lr_adapters.py b/src/pyXenium/benchmarking/cci_adapters.py similarity index 68% rename from src/pyXenium/benchmarking/lr_adapters.py rename to src/pyXenium/benchmarking/cci_adapters.py index 4136b1d..b91828a 100644 --- a/src/pyXenium/benchmarking/lr_adapters.py +++ b/src/pyXenium/benchmarking/cci_adapters.py @@ -7,6 +7,7 @@ import os import shutil import subprocess +import sys import time from dataclasses import asdict, dataclass, field from pathlib import Path @@ -24,7 +25,7 @@ DEFAULT_ATERA_WTA_BREAST_TBC_SUBDIR, ) -from .lr_atera import ( +from .cci_atera import ( ATERA_BENCHMARK_RELATIVE_ROOT, STANDARDIZED_RESULT_COLUMNS, load_method_registry, @@ -52,7 +53,7 @@ "scild", ) -EXTERNAL_ATTEMPT_METHODS = {"giotto", "spatalk", "niches", "cellnest", "cellagentchat", "scild"} +EXTERNAL_ATTEMPT_METHODS = {"giotto", "spatalk", "niches"} @dataclass(frozen=True) @@ -62,7 +63,7 @@ class MethodRunSpec: output_dir: Path database_mode: str = "common-db" phase: str = "smoke" - max_lr_pairs: int | None = None + max_cci_pairs: int | None = None n_perms: int = 100 benchmark_root: Path | None = None tbc_results: Path | None = None @@ -150,10 +151,10 @@ def check_bundle(bundle: Mapping[str, Any], label: str) -> None: if not Path(str(bundle[key])).exists(): issues.append(f"{label} bundle path for {key} does not exist: {bundle[key]}") - if not manifest.get("lr_db_common_tsv"): - issues.append("missing lr_db_common_tsv") - elif not Path(str(manifest["lr_db_common_tsv"])).exists(): - issues.append(f"lr_db_common_tsv does not exist: {manifest['lr_db_common_tsv']}") + if not manifest.get("cci_resource_common_tsv"): + issues.append("missing cci_resource_common_tsv") + elif not Path(str(manifest["cci_resource_common_tsv"])).exists(): + issues.append(f"cci_resource_common_tsv does not exist: {manifest['cci_resource_common_tsv']}") if manifest.get("smoke_h5ad"): if not Path(str(manifest["smoke_h5ad"])).exists(): issues.append(f"smoke_h5ad does not exist: {manifest['smoke_h5ad']}") @@ -314,11 +315,89 @@ def _package_versions(packages: Sequence[str]) -> dict[str, str]: return versions -def read_lr_resource( +def _benchmark_root_for_spec(spec: MethodRunSpec) -> Path: + if spec.benchmark_root is not None: + return Path(spec.benchmark_root) + return resolve_layout(relative_root=ATERA_BENCHMARK_RELATIVE_ROOT).root + + +def _external_source_dir(spec: MethodRunSpec, method: str) -> Path: + method_key = method.lower() + env_key = f"{method_key.upper()}_SRC" + candidates: list[Path] = [] + if os.environ.get(env_key): + candidates.append(Path(str(os.environ[env_key]))) + if os.environ.get("PDC_CCI_ROOT"): + candidates.append(Path(str(os.environ["PDC_CCI_ROOT"])) / "external_src" / method_key) + candidates.append(_benchmark_root_for_spec(spec) / "external_src" / method_key) + for candidate in candidates: + if candidate.exists(): + return candidate + checked = ", ".join(str(path) for path in candidates) + raise FileNotFoundError(f"Source checkout for {method_key} was not found. Checked: {checked}") + + +def _prepend_sys_path(path: str | Path) -> None: + text = str(Path(path)) + if text not in sys.path: + sys.path.insert(0, text) + + +def _run_logged_command( + command: Sequence[str], + *, + cwd: Path | None, + stdout_path: Path, + stderr_path: Path, + env: Mapping[str, str] | None = None, +) -> subprocess.CompletedProcess[str]: + stdout_path.parent.mkdir(parents=True, exist_ok=True) + stderr_path.parent.mkdir(parents=True, exist_ok=True) + completed = subprocess.run( + list(command), + cwd=str(cwd) if cwd is not None else None, + env=dict(env) if env is not None else None, + text=True, + stdout=subprocess.PIPE, + stderr=subprocess.PIPE, + check=False, + ) + stdout_path.write_text(completed.stdout, encoding="utf-8") + stderr_path.write_text(completed.stderr, encoding="utf-8") + if completed.returncode != 0: + raise RuntimeError( + f"Command failed with exit code {completed.returncode}: {' '.join(command)}. " + f"See {stdout_path} and {stderr_path}." + ) + return completed + + +def _filter_cci_resource_to_present_genes(cci_resource: pd.DataFrame, adata: ad.AnnData) -> pd.DataFrame: + genes = {str(gene) for gene in adata.var_names} + selected = cci_resource.loc[ + cci_resource["ligand"].astype(str).isin(genes) & cci_resource["receptor"].astype(str).isin(genes) + ].drop_duplicates(["ligand", "receptor"]) + if selected.empty: + raise ValueError("No common CCI pairs have both ligand and receptor genes present in the selected AnnData.") + return selected.reset_index(drop=True) + + +def _celltype_pair_from_token(token: str, labels: Sequence[str]) -> tuple[str, str]: + exact = {(f"{sender}_{receiver}", sender, receiver) for sender in labels for receiver in labels} + for candidate, sender, receiver in exact: + if token == candidate: + return sender, receiver + if "_" in token: + sender, receiver = token.rsplit("_", 1) + return sender, receiver + return token, token + + +def read_cci_resource( manifest: Mapping[str, Any], *, database_mode: str, - max_lr_pairs: int | None = None, + max_cci_pairs: int | None = None, ) -> pd.DataFrame | None: mode = _normalize_database_mode(database_mode) if mode == "native-db": @@ -327,7 +406,7 @@ def read_lr_resource( if mode == "smoke-panel": path_key = "atera_smoke_panel_tsv" else: - path_key = "lr_db_common_tsv" + path_key = "cci_resource_common_tsv" if not manifest.get(path_key): raise ValueError(f"Input manifest is missing {path_key!r} for database mode {mode!r}.") @@ -336,7 +415,7 @@ def read_lr_resource( resource = resource.rename(columns={old: new for old, new in rename.items() if old in resource.columns}) missing = [col for col in ("ligand", "receptor") if col not in resource.columns] if missing: - raise ValueError(f"LR resource {manifest[path_key]!r} is missing columns: {missing}") + raise ValueError(f"CCI resource {manifest[path_key]!r} is missing columns: {missing}") resource["ligand"] = resource["ligand"].astype(str) resource["receptor"] = resource["receptor"].astype(str) @@ -345,30 +424,30 @@ def read_lr_resource( if "evidence_weight" not in resource.columns: resource["evidence_weight"] = 1.0 resource = resource.drop_duplicates(["ligand", "receptor"]).reset_index(drop=True) - if max_lr_pairs is not None and max_lr_pairs > 0: - resource = resource.head(int(max_lr_pairs)).copy() + if max_cci_pairs is not None and max_cci_pairs > 0: + resource = resource.head(int(max_cci_pairs)).copy() return resource -def _select_lr_chunk( +def _select_cci_chunk( resource: pd.DataFrame, *, chunk_id: int | None = None, num_chunks: int | None = None, - max_lr_pairs: int | None = None, + max_cci_pairs: int | None = None, ) -> pd.DataFrame: selected = resource.drop_duplicates(["ligand", "receptor"]).reset_index(drop=True).copy() if num_chunks is not None or chunk_id is not None: if num_chunks is None or chunk_id is None: - raise ValueError("Both chunk_id and num_chunks must be provided for LR chunking.") + raise ValueError("Both chunk_id and num_chunks must be provided for CCI chunking.") if num_chunks <= 0: raise ValueError("num_chunks must be positive.") if chunk_id < 0 or chunk_id >= num_chunks: raise ValueError(f"chunk_id must be in [0, {num_chunks - 1}], got {chunk_id}.") indices = np.array_split(np.arange(len(selected)), int(num_chunks))[int(chunk_id)] selected = selected.iloc[indices].reset_index(drop=True) - if max_lr_pairs is not None and max_lr_pairs > 0: - selected = selected.head(int(max_lr_pairs)).copy() + if max_cci_pairs is not None and max_cci_pairs > 0: + selected = selected.head(int(max_cci_pairs)).copy() return selected @@ -388,13 +467,13 @@ def _dense_gene_matrix(adata: ad.AnnData, genes: Sequence[str]) -> np.ndarray: return np.asarray(values, dtype=float) -def aggregate_lr_by_spatial_neighbors( +def aggregate_cci_by_spatial_neighbors( adata: ad.AnnData, - lr_resource: pd.DataFrame, + cci_resource: pd.DataFrame, *, connectivity_key: str = "spatial_connectivities", global_scores: pd.DataFrame | None = None, - global_score_col: str = "LR_score", + global_score_col: str = "CCI_score", pvalue_col: str | None = "pvalue", ) -> pd.DataFrame: if connectivity_key not in adata.obsp: @@ -409,9 +488,9 @@ def aggregate_lr_by_spatial_neighbors( score_lookup[(str(row["ligand"]), str(row["receptor"]))] = row.to_dict() rows: list[dict[str, Any]] = [] - for _, lr in lr_resource.iterrows(): - ligand = str(lr["ligand"]) - receptor = str(lr["receptor"]) + for _, interaction in cci_resource.iterrows(): + ligand = str(interaction["ligand"]) + receptor = str(interaction["receptor"]) if ligand not in adata.var_names or receptor not in adata.var_names: continue ligand_expr = _dense_gene_vector(adata, ligand) @@ -438,8 +517,8 @@ def aggregate_lr_by_spatial_neighbors( "receptor": receptor, "sender_celltype": sender, "receiver_celltype": receiver, - "LR_score": local_score * positive_weight, - "local_lr_score": local_score, + "CCI_score": local_score * positive_weight, + "local_cci_score": local_score, "edge_count": edges, "spatial_coherence": local_score / edges if edges > 0 else np.nan, } @@ -454,14 +533,14 @@ def aggregate_lr_by_spatial_neighbors( return pd.DataFrame(rows) -def aggregate_lr_by_celltype_means(adata: ad.AnnData, lr_resource: pd.DataFrame) -> pd.DataFrame: +def aggregate_cci_by_celltype_means(adata: ad.AnnData, cci_resource: pd.DataFrame) -> pd.DataFrame: labels, _, one_hot = _celltype_one_hot(adata.obs["cell_type"].astype(str).to_numpy()) counts = np.asarray(one_hot.sum(axis=0)).reshape(-1) counts = np.where(counts > 0, counts, 1.0) rows: list[dict[str, Any]] = [] - for _, lr in lr_resource.iterrows(): - ligand = str(lr["ligand"]) - receptor = str(lr["receptor"]) + for _, interaction in cci_resource.iterrows(): + ligand = str(interaction["ligand"]) + receptor = str(interaction["receptor"]) if ligand not in adata.var_names or receptor not in adata.var_names: continue ligand_expr = _dense_gene_vector(adata, ligand) @@ -480,7 +559,7 @@ def aggregate_lr_by_celltype_means(adata: ad.AnnData, lr_resource: pd.DataFrame) "receptor": receptor, "sender_celltype": sender, "receiver_celltype": receiver, - "LR_score": score, + "CCI_score": score, "sender_mean_expr": float(ligand_mean[sender_idx]), "receiver_mean_expr": float(receptor_mean[receiver_idx]), } @@ -491,7 +570,7 @@ def aggregate_lr_by_celltype_means(adata: ad.AnnData, lr_resource: pd.DataFrame) def _prepare_expression_adata(adata: ad.AnnData, *, normalize: bool = True) -> ad.AnnData: prepared = adata.copy() if "cell_type" not in prepared.obs.columns: - raise ValueError("AnnData.obs must contain 'cell_type' for LR benchmark adapters.") + raise ValueError("AnnData.obs must contain 'cell_type' for CCI benchmark adapters.") if "spatial" not in prepared.obsm: spatial_cols = [col for col in ("x", "y") if col in prepared.obs.columns] if len(spatial_cols) == 2: @@ -577,7 +656,7 @@ def _gene_symbol_key(adata: ad.AnnData) -> str | None: return None -def _split_lr_token(value: Any) -> tuple[str, str]: +def _split_interaction_token(value: Any) -> tuple[str, str]: if isinstance(value, tuple) and len(value) >= 2: return str(value[0]), str(value[1]) token = str(value) @@ -602,7 +681,7 @@ def _split_sender_receiver(value: Any) -> tuple[str, str]: return token, token -def flatten_squidpy_ligrec_result(result: Mapping[str, Any]) -> pd.DataFrame: +def flatten_squidpy_cci_result(result: Mapping[str, Any]) -> pd.DataFrame: means = result.get("means") if not isinstance(means, pd.DataFrame): raise ValueError("Squidpy result must contain a 'means' DataFrame.") @@ -619,9 +698,9 @@ def flatten_squidpy_ligrec_result(result: Mapping[str, Any]) -> pd.DataFrame: ligand = meta.get("source", meta.get("ligand", None)) receptor = meta.get("target", meta.get("receptor", None)) if pd.isna(ligand) or pd.isna(receptor): - ligand, receptor = _split_lr_token(idx) + ligand, receptor = _split_interaction_token(idx) else: - ligand, receptor = _split_lr_token(idx) + ligand, receptor = _split_interaction_token(idx) for col in means.columns: sender, receiver = _split_sender_receiver(col) score = means.loc[idx, col] @@ -632,7 +711,7 @@ def flatten_squidpy_ligrec_result(result: Mapping[str, Any]) -> pd.DataFrame: "receptor": str(receptor), "sender_celltype": str(sender), "receiver_celltype": str(receiver), - "LR_score": score, + "CCI_score": score, "pvalue": pvalue, } ) @@ -650,14 +729,14 @@ def _celltype_one_hot(celltypes: Sequence[str]) -> tuple[list[str], np.ndarray, return labels, codes, one_hot -def _liana_lr_pairs(local_scores: ad.AnnData) -> list[tuple[str, str]]: +def _liana_interaction_pairs(local_scores: ad.AnnData) -> list[tuple[str, str]]: pairs: list[tuple[str, str]] = [] var = local_scores.var for idx, name in enumerate(local_scores.var_names.astype(str)): ligand = var.iloc[idx].get("ligand", var.iloc[idx].get("source", None)) receptor = var.iloc[idx].get("receptor", var.iloc[idx].get("target", None)) if pd.isna(ligand) or pd.isna(receptor): - ligand, receptor = _split_lr_token(name) + ligand, receptor = _split_interaction_token(name) pairs.append((str(ligand), str(receptor))) return pairs @@ -677,7 +756,7 @@ def aggregate_liana_bivariate_result( labels, receiver_codes, receiver_one_hot = _celltype_one_hot(source_adata.obs["cell_type"].astype(str).to_numpy()) conn = source_adata.obsp[connectivity_key].tocsr() sender_mix = np.asarray(conn @ receiver_one_hot.toarray(), dtype=float) - lr_pairs = _liana_lr_pairs(local_scores) + interaction_pairs = _liana_interaction_pairs(local_scores) score_matrix = local_scores.X rows: list[dict[str, Any]] = [] @@ -696,7 +775,7 @@ def aggregate_liana_bivariate_result( continue aggregate = block_dense[mask, :].T @ mix mean_scores = np.divide(aggregate, denom.reshape(1, -1), out=np.zeros_like(aggregate), where=denom.reshape(1, -1) > 0) - for local_col, (ligand, receptor) in enumerate(lr_pairs[start:end]): + for local_col, (ligand, receptor) in enumerate(interaction_pairs[start:end]): for sender_idx, sender in enumerate(labels): score = float(mean_scores[local_col, sender_idx]) if not np.isfinite(score) or score <= 0: @@ -707,7 +786,7 @@ def aggregate_liana_bivariate_result( "receptor": receptor, "sender_celltype": sender, "receiver_celltype": receiver, - "LR_score": score, + "CCI_score": score, "spatial_coherence": score, } ) @@ -716,15 +795,15 @@ def aggregate_liana_bivariate_result( def aggregate_commot_obsp_result( adata: ad.AnnData, - lr_resource: pd.DataFrame, + cci_resource: pd.DataFrame, *, database_name: str, ) -> pd.DataFrame: labels, _, one_hot = _celltype_one_hot(adata.obs["cell_type"].astype(str).to_numpy()) rows: list[dict[str, Any]] = [] - for _, lr in lr_resource.iterrows(): - ligand = str(lr["ligand"]) - receptor = str(lr["receptor"]) + for _, interaction in cci_resource.iterrows(): + ligand = str(interaction["ligand"]) + receptor = str(interaction["receptor"]) candidates = [ f"commot-{database_name}-{ligand}-{receptor}", f"commot-{database_name}-{ligand}-{receptor}".replace("/", "_"), @@ -752,7 +831,7 @@ def aggregate_commot_obsp_result( "receptor": receptor, "sender_celltype": sender, "receiver_celltype": receiver, - "LR_score": score, + "CCI_score": score, "communication_mass": score, "edge_count": edges, "spatial_coherence": score / edges if edges > 0 else np.nan, @@ -777,7 +856,7 @@ def _write_standardized( raw, method=method, database_mode=database_mode, - score_col="LR_score", + score_col="CCI_score", sender_col="sender_celltype", receiver_col="receiver_celltype", pvalue_col=pvalue_col, @@ -797,17 +876,17 @@ def run_squidpy_adapter(spec: MethodRunSpec) -> dict[str, Any]: import squidpy as sq # type: ignore except ImportError as exc: if "FSStore" in str(exc) or "zarr.storage" in str(exc): - raise ImportError("Squidpy import failed because the active environment has an incompatible zarr/ome-zarr stack. Rebuild pyx-lr-squidpy with the benchmark env file, which pins zarr<3.") from exc + raise ImportError("Squidpy import failed because the active environment has an incompatible zarr/ome-zarr stack. Rebuild pyx-cci-squidpy with the benchmark env file, which pins zarr<3.") from exc raise manifest = load_input_manifest(spec.input_manifest) - lr_resource = read_lr_resource(manifest, database_mode=spec.database_mode, max_lr_pairs=spec.max_lr_pairs) + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=spec.max_cci_pairs) raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) adata = _prepare_expression_adata(raw_adata, normalize=True) adata = ensure_categorical_obs(adata, "cell_type") interactions = None - if lr_resource is not None: - interactions = lr_resource.rename(columns={"ligand": "source", "receptor": "target"}).loc[:, ["source", "target"]] + if cci_resource is not None: + interactions = cci_resource.rename(columns={"ligand": "source", "receptor": "target"}).loc[:, ["source", "target"]] gene_symbols = _gene_symbol_key(adata) result = sq.gr.ligrec( @@ -828,7 +907,7 @@ def run_squidpy_adapter(spec: MethodRunSpec) -> dict[str, Any]: for key, value in result.items(): if isinstance(value, pd.DataFrame): _write_tsv(raw_dir / f"squidpy_{key}.tsv", value.reset_index()) - raw = flatten_squidpy_ligrec_result(result) + raw = flatten_squidpy_cci_result(result) raw_path = _write_tsv(raw_dir / "squidpy_flat.tsv", raw) standardized_path, standardized = _write_standardized( raw, @@ -850,7 +929,7 @@ def run_squidpy_adapter(spec: MethodRunSpec) -> dict[str, Any]: } -def _call_liana_bivariate(adata: ad.AnnData, lr_resource: pd.DataFrame | None, *, n_perms: int | None = None) -> ad.AnnData: +def _call_liana_bivariate(adata: ad.AnnData, cci_resource: pd.DataFrame | None, *, n_perms: int | None = None) -> ad.AnnData: import liana as li # type: ignore method_namespace = getattr(li, "mt", None) or getattr(li, "method", None) @@ -876,8 +955,8 @@ def _call_liana_bivariate(adata: ad.AnnData, lr_resource: pd.DataFrame | None, * "use_raw": False, "verbose": False, } - if lr_resource is not None: - kwargs["resource"] = lr_resource.loc[:, ["ligand", "receptor"]].copy() + if cci_resource is not None: + kwargs["resource"] = cci_resource.loc[:, ["ligand", "receptor"]].copy() kwargs["x_name"] = "ligand" kwargs["y_name"] = "receptor" else: @@ -898,12 +977,12 @@ def _call_liana_bivariate(adata: ad.AnnData, lr_resource: pd.DataFrame | None, * def run_liana_adapter(spec: MethodRunSpec) -> dict[str, Any]: manifest = load_input_manifest(spec.input_manifest) - lr_resource = read_lr_resource(manifest, database_mode=spec.database_mode, max_lr_pairs=spec.max_lr_pairs) + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=spec.max_cci_pairs) raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) adata = _prepare_expression_adata(raw_adata, normalize=True) ensure_spatial_connectivities(adata, key="spatial_connectivities") - local_scores = _call_liana_bivariate(adata, lr_resource, n_perms=spec.n_perms if spec.n_perms > 0 else None) + local_scores = _call_liana_bivariate(adata, cci_resource, n_perms=spec.n_perms if spec.n_perms > 0 else None) raw_dir = spec.output_dir / "raw" raw_dir.mkdir(parents=True, exist_ok=True) local_scores.write_h5ad(raw_dir / "liana_bivariate_local_scores.h5ad") @@ -915,7 +994,7 @@ def run_liana_adapter(spec: MethodRunSpec) -> dict[str, Any]: output_dir=spec.output_dir, method="liana", database_mode=spec.database_mode, - resolution="local_lr", + resolution="local_cci", spatial_support_type="spatial_bivariate_neighbor", extra_numeric_cols=("spatial_coherence",), gzip_output=spec.gzip_standardized, @@ -949,23 +1028,23 @@ def _commot_native_resource() -> pd.DataFrame: return resource.loc[:, ["ligand", "receptor", "pathway"]].drop_duplicates().reset_index(drop=True) except Exception: continue - raise RuntimeError("Could not load a COMMOT native ligand-receptor database.") + raise RuntimeError("Could not load a COMMOT native cell-cell interaction database.") def run_commot_adapter(spec: MethodRunSpec) -> dict[str, Any]: import commot as ct # type: ignore manifest = load_input_manifest(spec.input_manifest) - lr_resource = read_lr_resource(manifest, database_mode=spec.database_mode, max_lr_pairs=None) - if lr_resource is None: - lr_resource = _commot_native_resource() - lr_resource = _select_lr_chunk( - lr_resource, + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=None) + if cci_resource is None: + cci_resource = _commot_native_resource() + cci_resource = _select_cci_chunk( + cci_resource, chunk_id=spec.chunk_id, num_chunks=spec.num_chunks, - max_lr_pairs=spec.max_lr_pairs, + max_cci_pairs=spec.max_cci_pairs, ) - lr_resource = lr_resource.loc[:, ["ligand", "receptor", "pathway"]].copy() + cci_resource = cci_resource.loc[:, ["ligand", "receptor", "pathway"]].copy() raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) adata = _prepare_expression_adata(raw_adata, normalize=True) @@ -974,7 +1053,7 @@ def run_commot_adapter(spec: MethodRunSpec) -> dict[str, Any]: ct.tl.spatial_communication( adata, database_name=database_name, - df_ligrec=lr_resource, + df_ligrec=cci_resource, pathway_sum=True, heteromeric=True, heteromeric_delimiter="_", @@ -985,7 +1064,7 @@ def run_commot_adapter(spec: MethodRunSpec) -> dict[str, Any]: raw_dir = spec.output_dir / "raw" raw_dir.mkdir(parents=True, exist_ok=True) adata.write_h5ad(raw_dir / "commot_result.h5ad") - raw = aggregate_commot_obsp_result(adata, lr_resource, database_name=database_name) + raw = aggregate_commot_obsp_result(adata, cci_resource, database_name=database_name) raw_path = _write_tsv(raw_dir / "commot_flat.tsv", raw) standardized_path, standardized = _write_standardized( raw, @@ -1016,14 +1095,14 @@ def run_spatialdm_adapter(spec: MethodRunSpec) -> dict[str, Any]: from spatialdm.stats import Moran_R, rbfweight # type: ignore manifest = load_input_manifest(spec.input_manifest) - lr_resource = read_lr_resource(manifest, database_mode=spec.database_mode, max_lr_pairs=None) - if lr_resource is None: + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=None) + if cci_resource is None: raise NotImplementedError("SpatialDM native-db mode is not implemented in this benchmark adapter; use common-db.") - lr_resource = _select_lr_chunk( - lr_resource, + cci_resource = _select_cci_chunk( + cci_resource, chunk_id=spec.chunk_id, num_chunks=spec.num_chunks, - max_lr_pairs=spec.max_lr_pairs, + max_cci_pairs=spec.max_cci_pairs, ) raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) adata = _prepare_expression_adata(raw_adata, normalize=True) @@ -1032,7 +1111,7 @@ def run_spatialdm_adapter(spec: MethodRunSpec) -> dict[str, Any]: spatial_w, knn_connect = rbfweight(coords, l=spatial_scale, n_neighbors=6, single_cell=True) adata.obsp["spatial_connectivities"] = knn_connect.tocsr() if sparse.issparse(knn_connect) else sparse.csr_matrix(knn_connect) - available = lr_resource[lr_resource["ligand"].isin(adata.var_names) & lr_resource["receptor"].isin(adata.var_names)].reset_index(drop=True) + available = cci_resource[cci_resource["ligand"].isin(adata.var_names) & cci_resource["receptor"].isin(adata.var_names)].reset_index(drop=True) global_rows: list[pd.DataFrame] = [] batch_size = int(spec.extra.get("batch_size", 64)) if spec.extra else 64 for start in range(0, len(available), batch_size): @@ -1051,29 +1130,29 @@ def run_spatialdm_adapter(spec: MethodRunSpec) -> dict[str, Any]: { "ligand": ligands, "receptor": receptors, - "LR_score": score, + "CCI_score": score, "spatialdm_moran_r": moran_r, "spatialdm_zscore": zscore, "pvalue": pvalue, } ) ) - global_scores = pd.concat(global_rows, ignore_index=True) if global_rows else pd.DataFrame(columns=["ligand", "receptor", "LR_score"]) + global_scores = pd.concat(global_rows, ignore_index=True) if global_rows else pd.DataFrame(columns=["ligand", "receptor", "CCI_score"]) raw_dir = spec.output_dir / "raw" raw_dir.mkdir(parents=True, exist_ok=True) global_path = _write_tsv(raw_dir / "spatialdm_global.tsv", global_scores) - raw = aggregate_lr_by_spatial_neighbors(adata, available, global_scores=global_scores, pvalue_col="pvalue") + raw = aggregate_cci_by_spatial_neighbors(adata, available, global_scores=global_scores, pvalue_col="pvalue") raw_path = _write_tsv(raw_dir / "spatialdm_celltype_flat.tsv", raw) standardized_path, standardized = _write_standardized( raw, output_dir=spec.output_dir, method="spatialdm", database_mode=spec.database_mode, - resolution="local_lr", + resolution="local_cci", spatial_support_type="bivariate_moran_neighbor", pvalue_col="pvalue", - extra_numeric_cols=("local_lr_score", "edge_count", "spatial_coherence", "spatialdm_moran_r", "spatialdm_zscore"), + extra_numeric_cols=("local_cci_score", "edge_count", "spatial_coherence", "spatialdm_moran_r", "spatialdm_zscore"), gzip_output=spec.gzip_standardized, ) return { @@ -1097,19 +1176,19 @@ def run_stlearn_adapter(spec: MethodRunSpec) -> dict[str, Any]: import stlearn as st # type: ignore manifest = load_input_manifest(spec.input_manifest) - lr_resource = read_lr_resource(manifest, database_mode=spec.database_mode, max_lr_pairs=None) - if lr_resource is None: + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=None) + if cci_resource is None: try: native_lrs = st.tl.cci.load_lrs(["connectomeDB2020_lit"], species="human") except Exception as exc: raise NotImplementedError("stLearn native-db mode failed to load connectomeDB2020_lit.") from exc - lr_resource = pd.DataFrame([_split_lr_token(value) for value in native_lrs], columns=["ligand", "receptor"]) - lr_resource["pathway"] = "stlearn_native" - lr_resource = _select_lr_chunk( - lr_resource, + cci_resource = pd.DataFrame([_split_interaction_token(value) for value in native_lrs], columns=["ligand", "receptor"]) + cci_resource["pathway"] = "stlearn_native" + cci_resource = _select_cci_chunk( + cci_resource, chunk_id=spec.chunk_id, num_chunks=spec.num_chunks, - max_lr_pairs=spec.max_lr_pairs, + max_cci_pairs=spec.max_cci_pairs, ) raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) adata = raw_adata.copy() @@ -1125,7 +1204,7 @@ def run_stlearn_adapter(spec: MethodRunSpec) -> dict[str, Any]: adata.layers["counts"] = adata.X.copy() sc.pp.normalize_total(adata, target_sum=1e4) - lrs = np.asarray([f"{row.ligand}_{row.receptor}" for row in lr_resource.itertuples(index=False)], dtype=str) + lrs = np.asarray([f"{row.ligand}_{row.receptor}" for row in cci_resource.itertuples(index=False)], dtype=str) n_pairs = max(1, int(spec.n_perms)) st.tl.cci.run( adata, @@ -1137,30 +1216,30 @@ def run_stlearn_adapter(spec: MethodRunSpec) -> dict[str, Any]: ) summary = pd.DataFrame(adata.uns.get("lr_summary", pd.DataFrame())).copy() if summary.empty: - global_scores = pd.DataFrame(columns=["ligand", "receptor", "LR_score"]) + global_scores = pd.DataFrame(columns=["ligand", "receptor", "CCI_score"]) else: - summary = summary.reset_index(names="lr_pair") - pairs = summary["lr_pair"].map(_split_lr_token) + summary = summary.reset_index(names="interaction_pair") + pairs = summary["interaction_pair"].map(_split_interaction_token) summary["ligand"] = [p[0] for p in pairs] summary["receptor"] = [p[1] for p in pairs] score_col = "n_spots_sig" if "n_spots_sig" in summary.columns else "n_spots" - summary["LR_score"] = pd.to_numeric(summary.get(score_col, 0), errors="coerce").fillna(0.0) + 1e-12 - global_scores = summary.loc[:, [col for col in ["ligand", "receptor", "LR_score", "n_spots", "n_spots_sig", "n_spots_sig_pval"] if col in summary.columns]] + summary["CCI_score"] = pd.to_numeric(summary.get(score_col, 0), errors="coerce").fillna(0.0) + 1e-12 + global_scores = summary.loc[:, [col for col in ["ligand", "receptor", "CCI_score", "n_spots", "n_spots_sig", "n_spots_sig_pval"] if col in summary.columns]] ensure_spatial_connectivities(adata, key="spatial_connectivities") raw_dir = spec.output_dir / "raw" raw_dir.mkdir(parents=True, exist_ok=True) - summary_path = _write_tsv(raw_dir / "stlearn_lr_summary.tsv", global_scores) - raw = aggregate_lr_by_spatial_neighbors(adata, lr_resource, global_scores=global_scores, pvalue_col=None) + summary_path = _write_tsv(raw_dir / "stlearn_cci_summary.tsv", global_scores) + raw = aggregate_cci_by_spatial_neighbors(adata, cci_resource, global_scores=global_scores, pvalue_col=None) raw_path = _write_tsv(raw_dir / "stlearn_celltype_flat.tsv", raw) standardized_path, standardized = _write_standardized( raw, output_dir=spec.output_dir, method="stlearn", database_mode=spec.database_mode, - resolution="local_lr", - spatial_support_type="significant_lr_hotspot_neighbor", - extra_numeric_cols=("local_lr_score", "edge_count", "spatial_coherence", "n_spots", "n_spots_sig", "n_spots_sig_pval"), + resolution="local_cci", + spatial_support_type="significant_cci_hotspot_neighbor", + extra_numeric_cols=("local_cci_score", "edge_count", "spatial_coherence", "n_spots", "n_spots_sig", "n_spots_sig_pval"), gzip_output=spec.gzip_standardized, ) return { @@ -1180,18 +1259,18 @@ def run_stlearn_adapter(spec: MethodRunSpec) -> dict[str, Any]: def run_cellphonedb_baseline_adapter(spec: MethodRunSpec) -> dict[str, Any]: manifest = load_input_manifest(spec.input_manifest) - lr_resource = read_lr_resource(manifest, database_mode=spec.database_mode, max_lr_pairs=None) - if lr_resource is None: + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=None) + if cci_resource is None: raise NotImplementedError("CellPhoneDB native-db mode requires the external CellPhoneDB database export; use common-db for this baseline.") - lr_resource = _select_lr_chunk( - lr_resource, + cci_resource = _select_cci_chunk( + cci_resource, chunk_id=spec.chunk_id, num_chunks=spec.num_chunks, - max_lr_pairs=spec.max_lr_pairs, + max_cci_pairs=spec.max_cci_pairs, ) raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) adata = _prepare_expression_adata(raw_adata, normalize=True) - raw = aggregate_lr_by_celltype_means(adata, lr_resource) + raw = aggregate_cci_by_celltype_means(adata, cci_resource) raw_dir = spec.output_dir / "raw" raw_path = _write_tsv(raw_dir / "cellphonedb_mean_product_flat.tsv", raw) standardized_path, standardized = _write_standardized( @@ -1220,14 +1299,14 @@ def run_cellphonedb_baseline_adapter(spec: MethodRunSpec) -> dict[str, Any]: def run_laris_adapter(spec: MethodRunSpec) -> dict[str, Any]: manifest = load_input_manifest(spec.input_manifest) - lr_resource = read_lr_resource(manifest, database_mode=spec.database_mode, max_lr_pairs=None) - if lr_resource is None: + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=None) + if cci_resource is None: raise NotImplementedError("LARIS native-db mode is not implemented in this benchmark adapter; use common-db.") - lr_resource = _select_lr_chunk( - lr_resource, + cci_resource = _select_cci_chunk( + cci_resource, chunk_id=spec.chunk_id, num_chunks=spec.num_chunks, - max_lr_pairs=spec.max_lr_pairs, + max_cci_pairs=spec.max_cci_pairs, ) raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) adata = _prepare_expression_adata(raw_adata, normalize=True) @@ -1237,9 +1316,9 @@ def run_laris_adapter(spec: MethodRunSpec) -> dict[str, Any]: labels, _, one_hot = _celltype_one_hot(adata.obs["cell_type"].astype(str).to_numpy()) counts = np.asarray(one_hot.sum(axis=0)).reshape(-1) counts = np.where(counts > 0, counts, 1.0) - for _, lr in lr_resource.iterrows(): - ligand = str(lr["ligand"]) - receptor = str(lr["receptor"]) + for _, interaction in cci_resource.iterrows(): + ligand = str(interaction["ligand"]) + receptor = str(interaction["receptor"]) if ligand not in adata.var_names or receptor not in adata.var_names: continue ligand_expr = _dense_gene_vector(adata, ligand) @@ -1260,7 +1339,7 @@ def run_laris_adapter(spec: MethodRunSpec) -> dict[str, Any]: "receptor": receptor, "sender_celltype": sender, "receiver_celltype": receiver, - "LR_score": score, + "CCI_score": score, "sender_diffused_mean": float(ligand_mean[sender_idx]), "receiver_diffused_mean": float(receptor_mean[receiver_idx]), "diffusion_alpha": alpha, @@ -1275,7 +1354,7 @@ def run_laris_adapter(spec: MethodRunSpec) -> dict[str, Any]: method="laris", database_mode=spec.database_mode, resolution="celltype_pair", - spatial_support_type="knn_diffusion_lr", + spatial_support_type="knn_diffusion_cci", extra_numeric_cols=("sender_diffused_mean", "receiver_diffused_mean", "diffusion_alpha"), gzip_output=spec.gzip_standardized, ) @@ -1293,6 +1372,450 @@ def run_laris_adapter(spec: MethodRunSpec) -> dict[str, Any]: } +def _cellnest_command(script: Path, args: Sequence[str], *, source_dir: Path, work_dir: Path) -> list[str]: + image = os.environ.get("CELLNEST_CONTAINER") or os.environ.get("CELLNEST_IMAGE") + runtime = shutil.which("apptainer") or shutil.which("singularity") + if image and Path(image).exists() and runtime: + return [ + runtime, + "exec", + "--bind", + f"{source_dir}:{source_dir}", + "--bind", + f"{work_dir}:{work_dir}", + str(image), + "python", + str(script), + *list(args), + ] + return [sys.executable, str(script), *list(args)] + + +def _parse_cellnest_allccc(path: Path, source_adata: ad.AnnData) -> pd.DataFrame: + if not path.exists(): + raise FileNotFoundError(f"CellNEST postprocess output was not found: {path}") + table = pd.read_csv(path) + table.columns = [str(col).strip() for col in table.columns] + rename = { + "from_cell": "from_cell", + "to_cell": "to_cell", + "ligand": "ligand", + "receptor": "receptor", + "edge_rank": "edge_rank", + "attention_score": "attention_score", + } + missing = [col for col in ("from_cell", "to_cell", "ligand", "receptor") if col not in table.columns] + if missing: + raise ValueError(f"CellNEST allCCC output is missing required columns: {missing}") + table = table.rename(columns=rename).copy() + obs = source_adata.obs.copy() + obs.index = obs.index.astype(str) + celltype = obs["cell_type"].astype(str).to_dict() + table["sender_celltype"] = table["from_cell"].astype(str).map(celltype) + table["receiver_celltype"] = table["to_cell"].astype(str).map(celltype) + table = table.dropna(subset=["sender_celltype", "receiver_celltype"]) + if table.empty: + raise ValueError("CellNEST allCCC output did not contain cell IDs matching the benchmark AnnData.") + score_col = "attention_score" if "attention_score" in table.columns else "edge_rank" + table[score_col] = pd.to_numeric(table[score_col], errors="coerce") + if score_col == "edge_rank": + table["CCI_score"] = 1.0 / table["edge_rank"].replace(0, np.nan) + else: + table["CCI_score"] = table[score_col] + table = table.replace([np.inf, -np.inf], np.nan).dropna(subset=["CCI_score"]) + grouped = ( + table.groupby(["ligand", "receptor", "sender_celltype", "receiver_celltype"], as_index=False) + .agg(CCI_score=("CCI_score", "mean"), cell_pair_count=("CCI_score", "size")) + ) + return grouped + + +def run_cellnest_adapter(spec: MethodRunSpec) -> dict[str, Any]: + manifest = load_input_manifest(spec.input_manifest) + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=spec.max_cci_pairs) + if cci_resource is None: + raise NotImplementedError("CellNEST native-db mode is not supported by this standardized adapter; use common-db.") + raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) + raw_adata = _prepare_expression_adata(raw_adata, normalize=False) + cci_resource = _filter_cci_resource_to_present_genes(cci_resource, raw_adata) + + source_dir = _external_source_dir(spec, "cellnest") + raw_dir = spec.output_dir / "raw" + work_dir = raw_dir / "cellnest_work" + input_dir = work_dir / "input" + input_dir.mkdir(parents=True, exist_ok=True) + data_name = f"atera_{spec.phase}_{_safe_slug(spec.database_mode)}" + model_name = "CellNEST_atera" + h5ad_path = input_dir / f"{data_name}.h5ad" + raw_adata.write_h5ad(h5ad_path) + cci_csv = input_dir / "common_cci_cellnest.csv" + cellnest_cci = cci_resource.rename(columns={"ligand": "Ligand", "receptor": "Receptor"}).loc[:, ["Ligand", "Receptor"]].copy() + cellnest_cci["Annotation"] = "Benchmark common-db" + cellnest_cci["Reference"] = "pyXenium CCI benchmark" + cellnest_cci.to_csv(cci_csv, index=False) + + epochs_default = "1000" if spec.phase == "full" else "500" + num_epoch = int(os.environ.get("CELLNEST_NUM_EPOCH", epochs_default)) + hidden = int(os.environ.get("CELLNEST_HIDDEN", "64")) + common_env = {**os.environ, "PYTHONPATH": f"{source_dir}{os.pathsep}{os.environ.get('PYTHONPATH', '')}"} + preprocess_args = [ + "--data_name", + data_name, + "--data_from", + str(h5ad_path), + "--data_type", + "anndata", + "--data_to", + str(work_dir / "input_graph") + os.sep, + "--metadata_to", + str(work_dir / "metadata") + os.sep, + "--database_path", + str(cci_csv), + "--skip_normalize", + "1", + "--distance_measure", + "knn", + "--k", + os.environ.get("CELLNEST_K", "6"), + ] + _run_logged_command( + _cellnest_command(source_dir / "data_preprocess_CellNEST.py", preprocess_args, source_dir=source_dir, work_dir=work_dir), + cwd=source_dir, + stdout_path=raw_dir / "cellnest_preprocess.stdout.log", + stderr_path=raw_dir / "cellnest_preprocess.stderr.log", + env=common_env, + ) + run_args = [ + "--data_name", + data_name, + "--model_name", + model_name, + "--run_id", + "0", + "--num_epoch", + str(num_epoch), + "--model_path", + str(work_dir / "model") + os.sep, + "--embedding_path", + str(work_dir / "embedding_data") + os.sep, + "--training_data", + str(work_dir / "input_graph") + os.sep, + "--metadata_to", + str(work_dir / "metadata") + os.sep, + "--hidden", + str(hidden), + "--manual_seed", + "yes", + "--seed", + "0", + ] + _run_logged_command( + _cellnest_command(source_dir / "run_CellNEST.py", run_args, source_dir=source_dir, work_dir=work_dir), + cwd=source_dir, + stdout_path=raw_dir / "cellnest_run.stdout.log", + stderr_path=raw_dir / "cellnest_run.stderr.log", + env=common_env, + ) + post_args = [ + "--data_name", + data_name, + "--model_name", + model_name, + "--total_runs", + "1", + "--embedding_path", + str(work_dir / "embedding_data") + os.sep, + "--metadata_from", + str(work_dir / "metadata") + os.sep, + "--data_from", + str(work_dir / "input_graph") + os.sep, + "--output_path", + str(work_dir / "output") + os.sep, + "--top_percent", + "100", + "--output_all", + "1", + "--integrate_layers", + "1", + ] + _run_logged_command( + _cellnest_command(source_dir / "output_postprocess_CellNEST.py", post_args, source_dir=source_dir, work_dir=work_dir), + cwd=source_dir, + stdout_path=raw_dir / "cellnest_postprocess.stdout.log", + stderr_path=raw_dir / "cellnest_postprocess.stderr.log", + env=common_env, + ) + raw_path = work_dir / "output" / data_name / f"{model_name}_allCCC.csv" + raw = _parse_cellnest_allccc(raw_path, raw_adata) + if raw.empty: + raise ValueError("CellNEST completed but produced no standardized CCI rows.") + flat_path = _write_tsv(raw_dir / "cellnest_celltype_flat.tsv", raw) + standardized_path, standardized = _write_standardized( + raw, + output_dir=spec.output_dir, + method="cellnest", + database_mode=spec.database_mode, + resolution="celltype_pair", + spatial_support_type="cellnest_attention", + extra_numeric_cols=("cell_pair_count",), + gzip_output=spec.gzip_standardized, + ) + return { + "method": "cellnest", + "status": "success", + "raw_tsv": str(flat_path), + "cellnest_allccc": str(raw_path), + "standardized_tsv": str(standardized_path), + "standardized_tsv_gz": str(standardized_path) if str(standardized_path).endswith(".gz") else None, + "n_rows": int(len(standardized)), + "top_hit": standardized.head(1).to_dict(orient="records"), + "cellnest_num_epoch": num_epoch, + "cellnest_hidden": hidden, + } + + +def run_cellagentchat_adapter(spec: MethodRunSpec) -> dict[str, Any]: + manifest = load_input_manifest(spec.input_manifest) + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=None) + if cci_resource is None: + raise NotImplementedError("CellAgentChat native-db mode is not supported by this standardized adapter; use common-db.") + cci_resource = _select_cci_chunk( + cci_resource, + chunk_id=spec.chunk_id, + num_chunks=spec.num_chunks, + max_cci_pairs=spec.max_cci_pairs, + ) + raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) + adata = _prepare_expression_adata(raw_adata, normalize=True) + cci_resource = _filter_cci_resource_to_present_genes(cci_resource, adata) + source_dir = _external_source_dir(spec, "cellagentchat") + source_src = source_dir / "src" + _prepend_sys_path(source_src) + + from abm import CellModel # type: ignore + from model_setup import add_rates, feature_selection, load_tf_db, train # type: ignore + + raw_dir = spec.output_dir / "raw" + work_dir = raw_dir / "cellagentchat_work" + work_dir.mkdir(parents=True, exist_ok=True) + labels, _, _ = _celltype_one_hot(adata.obs["cell_type"].astype(str).to_numpy()) + cci_tsv = work_dir / "common_cci_cellagentchat.tsv" + cellagent_cci = pd.DataFrame( + { + "pair_id": np.arange(len(cci_resource), dtype=int), + "ligand": cci_resource["ligand"].astype(str).to_numpy(), + "receptor": cci_resource["receptor"].astype(str).to_numpy(), + } + ) + cellagent_cci.to_csv(cci_tsv, sep="\t", index=False) + coords = np.asarray(adata.obsm["spatial"], dtype=float) + x = coords[:, 0] + y = coords[:, 1] + x_span = float(np.ptp(x)) or 1.0 + y_span = float(np.ptp(y)) or 1.0 + adata.obs["x_true"] = x + adata.obs["y_true"] = y + adata.obs["x"] = np.clip(np.rint(((x - float(np.min(x))) / x_span) * 100.0), 0, 100).astype(int) + adata.obs["y"] = np.clip(np.rint(((y - float(np.min(y))) / y_span) * 100.0), 0, 100).astype(int) + adata.obs["Batch"] = adata.obs.get("Batch", "benchmark").astype(str) if "Batch" in adata.obs else "benchmark" + + lig_uni: dict[str, list[str]] = {} + rec_uni: dict[str, list[str]] = {} + for _, row in cci_resource.iterrows(): + ligand = str(row["ligand"]) + receptor = str(row["receptor"]) + lig_uni.setdefault(ligand, []).append(receptor) + rec_uni.setdefault(receptor, []).append(ligand) + interaction_pairs = [f"{ligand}_{receptor}" for ligand, receptors in lig_uni.items() for receptor in receptors] + old_cwd = Path.cwd() + os.chdir(source_src) + try: + tf_uni, rec_tf_uni = load_tf_db("human", adata, rec_uni) + epochs = int(os.environ.get("CELLAGENTCHAT_EPOCHS", "50" if spec.phase == "full" else "10")) + model_path = work_dir / "cellagentchat_model.pt" + mat, target = train(adata, lig_uni, rec_uni, tf_uni, rec_tf_uni, interaction_pairs, path=str(model_path), epochs=epochs) + finally: + os.chdir(old_cwd) + use_feature_selection = os.environ.get("CELLAGENTCHAT_FEATURE_SELECTION", "1").strip().lower() not in {"0", "false", "no"} + if use_feature_selection: + import torch + + try: + model_dl = torch.load(str(model_path), weights_only=False) + except TypeError: + model_dl = torch.load(str(model_path)) + conversion_rates = feature_selection(model=model_dl, mat=mat, C=target, rec_uni=rec_uni) + rates = add_rates(conversion_rates, rec_uni) + else: + rates = {receptor: 1.0 for receptor in rec_uni} + + model = CellModel( + N=len(adata.obs), + adata=adata, + lig_uni=lig_uni, + rec_uni=rec_uni, + rates=rates, + max_steps=int(os.environ.get("CELLAGENTCHAT_MAX_STEPS", "1")), + dist=True, + delta=float(os.environ.get("CELLAGENTCHAT_DELTA", "1")), + tau=float(os.environ.get("CELLAGENTCHAT_TAU", "2")), + diff=float(os.environ.get("CELLAGENTCHAT_DIFF", "1")), + rec_block=False, + net=str(model_path), + ) + for _ in range(model.max_steps): + model.step() + rows: list[dict[str, Any]] = [] + for cpair, cci_scores in model.results2.items(): + sender, receiver = _celltype_pair_from_token(str(cpair), labels) + for interaction_token, score in dict(cci_scores).items(): + ligand, receptor = ( + str(interaction_token).split("-", 1) + if "-" in str(interaction_token) + else _split_interaction_token(interaction_token) + ) + value = float(score) + if not np.isfinite(value) or value <= 0: + continue + rows.append( + { + "ligand": ligand, + "receptor": receptor, + "sender_celltype": sender, + "receiver_celltype": receiver, + "CCI_score": value, + } + ) + raw = pd.DataFrame(rows) + if raw.empty: + raise ValueError("CellAgentChat completed but produced no CCI interaction rows.") + flat_path = _write_tsv(raw_dir / "cellagentchat_celltype_flat.tsv", raw) + standardized_path, standardized = _write_standardized( + raw, + output_dir=spec.output_dir, + method="cellagentchat", + database_mode=spec.database_mode, + resolution="celltype_pair", + spatial_support_type="agent_based_cci", + gzip_output=spec.gzip_standardized, + ) + return { + "method": "cellagentchat", + "status": "success", + "raw_tsv": str(flat_path), + "standardized_tsv": str(standardized_path), + "standardized_tsv_gz": str(standardized_path) if str(standardized_path).endswith(".gz") else None, + "n_rows": int(len(standardized)), + "top_hit": standardized.head(1).to_dict(orient="records"), + "epochs": epochs, + "feature_selection": use_feature_selection, + "chunk_id": spec.chunk_id, + "num_chunks": spec.num_chunks, + } + + +def _scild_cci_database(cci_resource: pd.DataFrame) -> pd.DataFrame: + ligands = sorted(cci_resource["ligand"].astype(str).unique()) + receptors = sorted(cci_resource["receptor"].astype(str).unique()) + database = pd.DataFrame(0, index=ligands, columns=receptors, dtype=int) + for _, row in cci_resource.iterrows(): + database.loc[str(row["ligand"]), str(row["receptor"])] = 1 + return database + + +def run_scild_adapter(spec: MethodRunSpec) -> dict[str, Any]: + manifest = load_input_manifest(spec.input_manifest) + cci_resource = read_cci_resource(manifest, database_mode=spec.database_mode, max_cci_pairs=spec.max_cci_pairs) + if cci_resource is None: + raise NotImplementedError("SCILD native-db mode is not supported by this standardized adapter; use common-db.") + raw_adata, _ = load_adata_from_manifest(manifest, spec.phase) + adata = _prepare_expression_adata(raw_adata, normalize=True) + if not sparse.issparse(adata.X): + adata.X = sparse.csr_matrix(adata.X) + else: + adata.X = adata.X.tocsr() + cci_resource = _filter_cci_resource_to_present_genes(cci_resource, adata) + source_dir = _external_source_dir(spec, "scild") + _prepend_sys_path(source_dir) + from Models.SCILD_main import SCILD # type: ignore + + np.random.seed(0) + cci_database = _scild_cci_database(cci_resource) + niter_max = int(os.environ.get("SCILD_NITER_MAX", "100" if spec.phase == "full" else "20")) + scild = SCILD( + adata=adata, + LRDatabase_D=cci_database, + neighbor_k=int(os.environ.get("SCILD_NEIGHBOR_K", "5")), + niter_max=niter_max, + eps=float(os.environ.get("SCILD_EPS", "1e-4")), + verbose=True, + plot_error=False, + ) + scild.preparing() + mu0 = np.random.random(scild.nl * scild.ns).reshape(-1, 1) + v0 = np.random.random(scild.nr * scild.ns).reshape(-1, 1) + scild.solving_optimization(mu0, v0) + + labels, _, one_hot = _celltype_one_hot(adata.obs["cell_type"].astype(str).to_numpy()) + rows: list[dict[str, Any]] = [] + p_matrix = scild.P.tocsr() + cell_indices = np.arange(scild.ns) + for ligand_idx, ligand in enumerate(scild.LRDatabase_D.index.astype(str)): + row_index = ligand_idx + cell_indices * scild.nl + for receptor_idx, receptor in enumerate(scild.LRDatabase_D.columns.astype(str)): + if scild.LRDatabase_D.iloc[ligand_idx, receptor_idx] != 1: + continue + col_index = receptor_idx + cell_indices * scild.nr + pair_matrix = p_matrix[row_index, :][:, col_index].tocsr() + aggregate = one_hot.T @ pair_matrix @ one_hot + edge_counts = one_hot.T @ pair_matrix.astype(bool).astype(float) @ one_hot + aggregate_arr = np.asarray(aggregate.toarray() if sparse.issparse(aggregate) else aggregate, dtype=float) + edge_arr = np.asarray(edge_counts.toarray() if sparse.issparse(edge_counts) else edge_counts, dtype=float) + for sender_idx, sender in enumerate(labels): + for receiver_idx, receiver in enumerate(labels): + score = float(aggregate_arr[sender_idx, receiver_idx]) + if not np.isfinite(score) or score <= 0: + continue + edges = float(edge_arr[sender_idx, receiver_idx]) + rows.append( + { + "ligand": ligand, + "receptor": receptor, + "sender_celltype": sender, + "receiver_celltype": receiver, + "CCI_score": score, + "communication_mass": score, + "edge_count": edges, + "spatial_coherence": score / edges if edges > 0 else np.nan, + } + ) + raw = pd.DataFrame(rows) + if raw.empty: + raise ValueError("SCILD completed but produced no CCI interaction rows.") + raw_dir = spec.output_dir / "raw" + flat_path = _write_tsv(raw_dir / "scild_celltype_flat.tsv", raw) + standardized_path, standardized = _write_standardized( + raw, + output_dir=spec.output_dir, + method="scild", + database_mode=spec.database_mode, + resolution="celltype_pair", + spatial_support_type="scild_probability", + extra_numeric_cols=("communication_mass", "edge_count", "spatial_coherence"), + gzip_output=spec.gzip_standardized, + ) + return { + "method": "scild", + "status": "success", + "raw_tsv": str(flat_path), + "standardized_tsv": str(standardized_path), + "standardized_tsv_gz": str(standardized_path) if str(standardized_path).endswith(".gz") else None, + "n_rows": int(len(standardized)), + "top_hit": standardized.head(1).to_dict(orient="records"), + "niter_max": niter_max, + } + + def run_external_attempt_adapter(spec: MethodRunSpec, *, package_candidates: Sequence[str]) -> dict[str, Any]: if spec.method in {"giotto", "spatalk", "niches"}: rscript = spec.rscript or os.environ.get("RSCRIPT", "Rscript") @@ -1350,7 +1873,7 @@ def run_external_attempt_adapter(spec: MethodRunSpec, *, package_candidates: Seq "database_mode": spec.database_mode, "reason": "No supported package distribution was importable in the method-specific environment.", "package_candidates": list(package_candidates), - "reproduce": f"conda run --name python -m pyXenium benchmark atera-lr run-method --method {spec.method}", + "reproduce": f"conda run --name python -m pyXenium benchmark atera-cci run-method --method {spec.method}", } _write_json(spec.output_dir / "run_summary.json", payload) _write_method_card(spec.output_dir, payload) @@ -1363,7 +1886,7 @@ def run_external_attempt_adapter(spec: MethodRunSpec, *, package_candidates: Seq "reason": "Package is installed, but a stable benchmark adapter for its public API has not been finalized yet.", "package_versions": found, "package_candidates": list(package_candidates), - "reproduce": f"conda run --name python -m pyXenium benchmark atera-lr run-method --method {spec.method}", + "reproduce": f"conda run --name python -m pyXenium benchmark atera-cci run-method --method {spec.method}", } _write_json(spec.output_dir / "run_summary.json", payload) _write_method_card(spec.output_dir, payload) @@ -1381,7 +1904,7 @@ def run_cellchat_subprocess(spec: MethodRunSpec) -> dict[str, Any]: "method": "cellchat", "status": "failed", "reason": f"Rscript executable was not found: {rscript}", - "reproduce": f"conda run --name r-lr-cellchat Rscript {script} --method cellchat --input-manifest {spec.input_manifest} --output-dir {spec.output_dir}", + "reproduce": f"conda run --name r-cci-cellchat Rscript {script} --method cellchat --input-manifest {spec.input_manifest} --output-dir {spec.output_dir}", } _write_json(spec.output_dir / "run_summary.json", payload) _write_method_card(spec.output_dir, payload) @@ -1401,8 +1924,8 @@ def run_cellchat_subprocess(spec: MethodRunSpec) -> dict[str, Any]: "--phase", spec.phase, ] - if spec.max_lr_pairs is not None: - command.extend(["--max-lr-pairs", str(spec.max_lr_pairs)]) + if spec.max_cci_pairs is not None: + command.extend(["--max-cci-pairs", str(spec.max_cci_pairs)]) completed = subprocess.run(command, text=True, stdout=subprocess.PIPE, stderr=subprocess.PIPE, check=False) (spec.output_dir / "cellchat_stdout.log").write_text(completed.stdout, encoding="utf-8") (spec.output_dir / "cellchat_stderr.log").write_text(completed.stderr, encoding="utf-8") @@ -1431,7 +1954,7 @@ def build_method_run_plan( benchmark_root: str | Path | None = None, database_mode: str = "common-db", phase: str = "smoke", - max_lr_pairs: int | None = None, + max_cci_pairs: int | None = None, n_perms: int = 100, chunk_id: int | None = None, num_chunks: int | None = None, @@ -1451,7 +1974,7 @@ def build_method_run_plan( raise ValueError(f"Method {method!r} is not registered in {layout.config_dir / 'methods.yaml'}.") resolved_output_dir = Path(output_dir) if output_dir else layout.runs_dir / f"{method_key}_{phase}_{_safe_slug(mode)}" input_source = select_input_source(manifest, phase) - lr_resource = read_lr_resource(manifest, database_mode=mode, max_lr_pairs=max_lr_pairs) + cci_resource = read_cci_resource(manifest, database_mode=mode, max_cci_pairs=max_cci_pairs) runner = layout.root / str(method_info.get("runner", "")) return { "method": method_key, @@ -1466,7 +1989,7 @@ def build_method_run_plan( "output_dir": str(resolved_output_dir), "database_mode": mode, "phase": phase, - "max_lr_pairs": max_lr_pairs, + "max_cci_pairs": max_cci_pairs, "n_perms": n_perms, "chunk_id": chunk_id, "num_chunks": num_chunks, @@ -1474,7 +1997,7 @@ def build_method_run_plan( "gpu_id": gpu_id, "job_id": job_id, "gzip_standardized": gzip_standardized, - "lr_pairs": None if lr_resource is None else int(len(lr_resource)), + "interaction_pairs": None if cci_resource is None else int(len(cci_resource)), "will_execute": method_key in SUPPORTED_REAL_ADAPTERS, } @@ -1487,7 +2010,7 @@ def run_registered_method( benchmark_root: str | Path | None = None, database_mode: str = "common-db", phase: str = "smoke", - max_lr_pairs: int | None = None, + max_cci_pairs: int | None = None, n_perms: int = 100, tbc_results: str | Path | None = None, export_figures: bool = False, @@ -1506,7 +2029,7 @@ def run_registered_method( benchmark_root=benchmark_root, database_mode=database_mode, phase=phase, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, chunk_id=chunk_id, num_chunks=num_chunks, @@ -1524,13 +2047,13 @@ def run_registered_method( manifest_path = Path(plan["input_manifest"]) manifest = load_input_manifest(manifest_path) input_source = select_input_source(manifest, phase) - lr_resource = read_lr_resource(manifest, database_mode=plan["database_mode"], max_lr_pairs=max_lr_pairs) + cci_resource = read_cci_resource(manifest, database_mode=plan["database_mode"], max_cci_pairs=max_cci_pairs) input_fingerprint_path = input_source["path"] if input_source.get("path") else manifest_path params = { **plan, "input_fingerprint": _file_fingerprint(input_fingerprint_path), "input_manifest_sha256": _file_sha256(manifest_path), - "lr_resource_sha256": None if lr_resource is None else _file_sha256(str(manifest["lr_db_common_tsv"])) if plan["database_mode"] == "common-db" else None, + "cci_resource_sha256": None if cci_resource is None else _file_sha256(str(manifest["cci_resource_common_tsv"])) if plan["database_mode"] == "common-db" else None, } _write_json(resolved_output_dir / "params.json", params) @@ -1540,7 +2063,7 @@ def run_registered_method( output_dir=resolved_output_dir, database_mode=plan["database_mode"], phase=phase, - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, benchmark_root=Path(benchmark_root) if benchmark_root else None, tbc_results=Path(tbc_results) if tbc_results else None, @@ -1567,11 +2090,11 @@ def run_registered_method( if method_key == "pyxenium": if plan["database_mode"] == "native-db": raise ValueError("pyXenium topology adapter does not expose a native database mode; use common-db or smoke-panel.") - lr_path = manifest.get("lr_db_common_tsv") if plan["database_mode"] == "common-db" else manifest.get("atera_smoke_panel_tsv") - if max_lr_pairs is not None and lr_path: - limited = read_lr_resource(manifest, database_mode=plan["database_mode"], max_lr_pairs=max_lr_pairs) - lr_path = resolved_output_dir / "raw" / "limited_lr_panel.tsv" - _write_tsv(lr_path, limited if limited is not None else pd.DataFrame()) + cci_path = manifest.get("cci_resource_common_tsv") if plan["database_mode"] == "common-db" else manifest.get("atera_smoke_panel_tsv") + if max_cci_pairs is not None and cci_path: + limited = read_cci_resource(manifest, database_mode=plan["database_mode"], max_cci_pairs=max_cci_pairs) + cci_path = resolved_output_dir / "raw" / "limited_cci_resource.tsv" + _write_tsv(cci_path, limited if limited is not None else pd.DataFrame()) if input_source["kind"] == "h5ad": selected_h5ad = Path(str(input_source["path"])) else: @@ -1584,7 +2107,7 @@ def run_registered_method( input_h5ad=selected_h5ad, output_dir=resolved_output_dir, tbc_results=tbc_results or manifest.get("tbc_results") or Path(DEFAULT_ATERA_WTA_BREAST_DATASET_PATH) / DEFAULT_ATERA_WTA_BREAST_TBC_SUBDIR, - lr_panel_path=lr_path, + cci_panel_path=cci_path, database_mode=plan["database_mode"], export_figures=export_figures, ) @@ -1611,11 +2134,11 @@ def run_registered_method( elif method_key == "niches": payload = run_external_attempt_adapter(spec, package_candidates=("NICHES",)) elif method_key == "cellnest": - payload = run_external_attempt_adapter(spec, package_candidates=("CellNEST", "cellnest")) + payload = run_cellnest_adapter(spec) elif method_key == "cellagentchat": - payload = run_external_attempt_adapter(spec, package_candidates=("CellAgentChat", "cellagentchat")) + payload = run_cellagentchat_adapter(spec) elif method_key == "scild": - payload = run_external_attempt_adapter(spec, package_candidates=("SCILD", "scild")) + payload = run_scild_adapter(spec) else: raise NotImplementedError(f"Method {method_key!r} does not have a real adapter yet.") payload = { @@ -1646,7 +2169,7 @@ def run_smoke_core( input_manifest: str | Path | None = None, benchmark_root: str | Path | None = None, database_mode: str = "common-db", - max_lr_pairs: int | None = None, + max_cci_pairs: int | None = None, n_perms: int = 100, dry_run: bool = False, continue_on_error: bool = True, @@ -1668,7 +2191,7 @@ def run_smoke_core( benchmark_root=benchmark_root, database_mode=database_mode, phase="smoke", - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, ) payload["status"] = "dry-run" @@ -1680,7 +2203,7 @@ def run_smoke_core( benchmark_root=benchmark_root, database_mode=database_mode, phase="smoke", - max_lr_pairs=max_lr_pairs, + max_cci_pairs=max_cci_pairs, n_perms=n_perms, ) rows.append(payload) diff --git a/src/pyXenium/benchmarking/lr_atera.py b/src/pyXenium/benchmarking/cci_atera.py similarity index 96% rename from src/pyXenium/benchmarking/lr_atera.py rename to src/pyXenium/benchmarking/cci_atera.py index fcbd5a3..9edbca0 100644 --- a/src/pyXenium/benchmarking/lr_atera.py +++ b/src/pyXenium/benchmarking/cci_atera.py @@ -16,15 +16,15 @@ from scipy import sparse from scipy.io import mmwrite -from pyXenium.ligand_receptor import ligand_receptor_topology_analysis +from pyXenium.cci import cci_topology_analysis from pyXenium.validation.atera_wta_breast_topology import ( DEFAULT_ATERA_WTA_BREAST_CELL_GROUPS, DEFAULT_ATERA_WTA_BREAST_DATASET_PATH, DEFAULT_ATERA_WTA_BREAST_TBC_SUBDIR, - DEFAULT_LR_SMOKE_PANEL, + DEFAULT_CCI_SMOKE_PANEL, ) -ATERA_BENCHMARK_RELATIVE_ROOT = Path("benchmarking") / "lr_2026_atera" +ATERA_BENCHMARK_RELATIVE_ROOT = Path("benchmarking") / "cci_2026_atera" STANDARDIZED_RESULT_COLUMNS = [ "method", "database_mode", @@ -131,7 +131,7 @@ def _as_sparse_matrix(matrix: Any) -> sparse.spmatrix: def harmonize_adata_for_benchmark(adata: ad.AnnData, *, cell_type_col: str = "cluster", copy: bool = True) -> ad.AnnData: bench = adata.copy() if copy else adata if "spatial" not in bench.obsm: - raise ValueError("AnnData must contain .obsm['spatial'] to participate in the LR benchmark.") + raise ValueError("AnnData must contain .obsm['spatial'] to participate in the CCI benchmark.") bench.obs = bench.obs.copy() bench.var = bench.var.copy() @@ -270,7 +270,7 @@ def _build_celltype_pairs(celltypes: Sequence[str]) -> pd.DataFrame: return pd.DataFrame(rows) -def _default_lr_common_db(adata: ad.AnnData) -> tuple[pd.DataFrame, dict[str, Any]]: +def _default_cci_common_resource(adata: ad.AnnData) -> tuple[pd.DataFrame, dict[str, Any]]: genes = set(adata.var_names.astype(str)) resource: pd.DataFrame | None = None source = "liana_consensus" @@ -280,7 +280,7 @@ def _default_lr_common_db(adata: ad.AnnData) -> tuple[pd.DataFrame, dict[str, An resource = li.resource.select_resource("consensus")[["ligand", "receptor"]].drop_duplicates() except Exception: source = "atera_smoke_panel_fallback" - resource = DEFAULT_LR_SMOKE_PANEL.loc[:, ["ligand", "receptor"]].drop_duplicates() + resource = DEFAULT_CCI_SMOKE_PANEL.loc[:, ["ligand", "receptor"]].drop_duplicates() resource = resource.copy() resource["ligand"] = resource["ligand"].astype(str) @@ -289,13 +289,13 @@ def _default_lr_common_db(adata: ad.AnnData) -> tuple[pd.DataFrame, dict[str, An if resource.empty: source = "smoke_panel_only" - resource = DEFAULT_LR_SMOKE_PANEL.loc[:, ["ligand", "receptor"]].drop_duplicates().copy() + resource = DEFAULT_CCI_SMOKE_PANEL.loc[:, ["ligand", "receptor"]].drop_duplicates().copy() resource = resource.sort_values(["ligand", "receptor"]).reset_index(drop=True) return resource, {"source": source, "n_pairs": int(len(resource))} -def prepare_atera_lr_benchmark( +def prepare_atera_cci_benchmark( *, dataset_root: str | Path | None = DEFAULT_ATERA_WTA_BREAST_DATASET_PATH, benchmark_root: str | Path | None = None, @@ -341,13 +341,13 @@ def prepare_atera_lr_benchmark( full_bundle = _write_sparse_bundle(adata, full_dir) if export_full_bundle else {} smoke_bundle = _write_sparse_bundle(smoke, smoke_dir) - common_db, common_db_meta = _default_lr_common_db(adata) + common_db, common_db_meta = _default_cci_common_resource(adata) common_db["evidence_weight"] = 1.0 - common_db_path = layout.data_dir / "lr_db_common.tsv" + common_db_path = layout.data_dir / "cci_resource_common.tsv" common_db.to_csv(common_db_path, sep="\t", index=False) smoke_panel_path = layout.data_dir / "atera_smoke_panel.tsv" - smoke_panel = DEFAULT_LR_SMOKE_PANEL.copy() + smoke_panel = DEFAULT_CCI_SMOKE_PANEL.copy() smoke_panel.to_csv(smoke_panel_path, sep="\t", index=False) celltype_pairs = _build_celltype_pairs(adata.obs["cell_type"].astype(str)) @@ -363,7 +363,7 @@ def prepare_atera_lr_benchmark( "benchmark_root": str(layout.root), "full_h5ad": str(full_h5ad) if export_full_bundle and write_full_h5ad else None, "smoke_h5ad": str(smoke_h5ad), - "lr_db_common_tsv": str(common_db_path), + "cci_resource_common_tsv": str(common_db_path), "atera_smoke_panel_tsv": str(smoke_panel_path), "celltype_pairs_tsv": str(celltype_pairs_path), "full_bundle": full_bundle, @@ -439,7 +439,7 @@ def standardize_result_table( receptor_col: str = "receptor", sender_col: str = "sender_celltype", receiver_col: str = "receiver_celltype", - score_col: str = "LR_score", + score_col: str = "CCI_score", pvalue_col: str | None = None, resolution: str = "celltype_pair", spatial_support_type: str = "local_contact", @@ -484,7 +484,7 @@ def run_pyxenium_smoke( input_h5ad: str | Path, output_dir: str | Path, tbc_results: str | Path, - lr_panel_path: str | Path | None = None, + cci_panel_path: str | Path | None = None, database_mode: str = "common-db", export_figures: bool = False, ) -> dict[str, Any]: @@ -495,13 +495,13 @@ def run_pyxenium_smoke( tbc_results = _portable_path(tbc_results) adata = ad.read_h5ad(input_h5ad) - lr_pairs = pd.read_csv(lr_panel_path, sep="\t") if lr_panel_path else DEFAULT_LR_SMOKE_PANEL.copy() - if "evidence_weight" not in lr_pairs.columns: - lr_pairs["evidence_weight"] = 1.0 + interaction_pairs = pd.read_csv(cci_panel_path, sep="\t") if cci_panel_path else DEFAULT_CCI_SMOKE_PANEL.copy() + if "evidence_weight" not in interaction_pairs.columns: + interaction_pairs["evidence_weight"] = 1.0 - result = ligand_receptor_topology_analysis( + result = cci_topology_analysis( adata=adata, - lr_pairs=lr_pairs, + interaction_pairs=interaction_pairs, output_dir=artifact_dir, tbc_results=tbc_results, cluster_col="cell_type", @@ -509,7 +509,7 @@ def run_pyxenium_smoke( x_col="x", y_col="y", anchor_mode="precomputed", - top_n_pairs=min(len(lr_pairs), 50), + top_n_pairs=min(len(interaction_pairs), 50), min_cross_edges=50, export_figures=export_figures, use_raw=False, @@ -519,7 +519,7 @@ def run_pyxenium_smoke( scores, method="pyxenium", database_mode=database_mode, - score_col="LR_score", + score_col="CCI_score", sender_col="sender_celltype", receiver_col="receiver_celltype", spatial_support_type="topology_local_contact", @@ -536,7 +536,7 @@ def run_pyxenium_smoke( "method": "pyxenium", "database_mode": database_mode, "input_h5ad": str(input_h5ad), - "lr_panel_path": str(lr_panel_path) if lr_panel_path else None, + "cci_panel_path": str(cci_panel_path) if cci_panel_path else None, "scores_tsv": str(scores_path), "standardized_tsv": str(standardized_path), "artifact_dir": str(artifact_dir), @@ -854,7 +854,7 @@ def build_canonical_rank_matrix(canonical_detail: pd.DataFrame) -> pd.DataFrame: return pivot.reset_index() -def render_atera_lr_benchmark_report( +def render_atera_cci_benchmark_report( *, combined_results: pd.DataFrame, canonical_summary: pd.DataFrame, @@ -867,7 +867,7 @@ def render_atera_lr_benchmark_report( a100_resource_summary: pd.DataFrame | None = None, ) -> str: lines = [ - "# Atera Xenium LR Benchmark", + "# Atera Xenium CCI Benchmark", "", f"- Benchmark root: `{Path(benchmark_root)}`", f"- Methods with standardized results: `{combined_results['method'].nunique() if not combined_results.empty else 0}`", diff --git a/src/pyXenium/cci/__init__.py b/src/pyXenium/cci/__init__.py new file mode 100644 index 0000000..0d9751e --- /dev/null +++ b/src/pyXenium/cci/__init__.py @@ -0,0 +1,5 @@ +from __future__ import annotations + +from ._analysis import cci_topology_analysis + +__all__ = ["cci_topology_analysis"] diff --git a/src/pyXenium/ligand_receptor/_analysis.py b/src/pyXenium/cci/_analysis.py similarity index 85% rename from src/pyXenium/ligand_receptor/_analysis.py rename to src/pyXenium/cci/_analysis.py index 1d5173d..3c31da5 100644 --- a/src/pyXenium/ligand_receptor/_analysis.py +++ b/src/pyXenium/cci/_analysis.py @@ -14,7 +14,7 @@ ensure_figures_dir, ensure_output_dir, geometric_mean, - normalize_lr_prior, + normalize_interaction_prior, prepare_hotspot_table, resolve_gene_topology_anchors, save_hotspot_overlay, @@ -25,11 +25,11 @@ ) -def ligand_receptor_topology_analysis( +def cci_topology_analysis( *, reference_df: Optional[pd.DataFrame] = None, expression_df: Optional[pd.DataFrame] = None, - lr_pairs: pd.DataFrame, + interaction_pairs: pd.DataFrame, output_dir: Optional[str | Path] = None, adata: Any = None, entity_points_df: Optional[pd.DataFrame] = None, @@ -61,7 +61,7 @@ def ligand_receptor_topology_analysis( use_raw: bool = False, ) -> dict[str, Any]: """ - Score ligand-receptor hypotheses using topology anchors, sender/receiver + Score cell-cell interaction hypotheses using topology anchors, sender/receiver expression support, and de-saturated local contact structure. """ @@ -69,8 +69,8 @@ def ligand_receptor_topology_analysis( raise ValueError("expression_support_mode currently supports only 'pseudobulk_detection'.") if contact_mode != "strength_coverage": raise ValueError("contact_mode currently supports only 'strength_coverage'.") - if ligand_col not in lr_pairs.columns or receptor_col not in lr_pairs.columns: - raise ValueError(f"lr_pairs must contain {ligand_col!r} and {receptor_col!r}.") + if ligand_col not in interaction_pairs.columns or receptor_col not in interaction_pairs.columns: + raise ValueError(f"interaction_pairs must contain {ligand_col!r} and {receptor_col!r}.") reference = coerce_reference_df( reference_df, @@ -84,10 +84,10 @@ def ligand_receptor_topology_analysis( reference.index = reference[cell_id_col].astype(str) reference["cell_id"] = reference[cell_id_col].astype(str) - pairs = lr_pairs.copy() + pairs = interaction_pairs.copy() pairs[ligand_col] = pairs[ligand_col].astype(str) pairs[receptor_col] = pairs[receptor_col].astype(str) - pairs["prior_confidence"] = normalize_lr_prior(pairs, prior_col) + pairs["prior_confidence"] = normalize_interaction_prior(pairs, prior_col) genes = list(dict.fromkeys(pairs[ligand_col].tolist() + pairs[receptor_col].tolist())) expression = coerce_expression_df( @@ -191,7 +191,7 @@ def ligand_receptor_topology_analysis( "contact_coverage": float(contact_coverage.loc[sender, receiver]), "cross_edge_count": int(cross_edge_count.loc[sender, receiver]), "prior_confidence": prior, - "LR_score": float( + "CCI_score": float( geometric_mean( [ float(sender_anchor.loc[sender]), @@ -209,7 +209,7 @@ def ligand_receptor_topology_analysis( scores = pd.DataFrame(score_rows) if not scores.empty: - scores = scores.sort_values("LR_score", ascending=False).reset_index(drop=True) + scores = scores.sort_values("CCI_score", ascending=False).reset_index(drop=True) component_diagnostics = scores.copy() out_dir = ensure_output_dir(output_dir) @@ -219,36 +219,36 @@ def ligand_receptor_topology_analysis( if out_dir is not None: ligand_path = out_dir / "ligand_to_cell.csv" receptor_path = out_dir / "receptor_to_cell.csv" - scores_path = out_dir / "lr_sender_receiver_scores.csv" - diagnostics_path = out_dir / "lr_component_diagnostics.csv" + scores_path = out_dir / "cci_sender_receiver_scores.csv" + diagnostics_path = out_dir / "cci_component_diagnostics.csv" ligand_to_cell.to_csv(ligand_path) receptor_to_cell.to_csv(receptor_path) scores.to_csv(scores_path, index=False) component_diagnostics.to_csv(diagnostics_path, index=False) output_files["ligand_to_cell"] = str(ligand_path) output_files["receptor_to_cell"] = str(receptor_path) - output_files["lr_sender_receiver_scores"] = str(scores_path) - output_files["lr_component_diagnostics"] = str(diagnostics_path) + output_files["cci_sender_receiver_scores"] = str(scores_path) + output_files["cci_component_diagnostics"] = str(diagnostics_path) if export_figures and figures_dir is not None and not scores.empty: summary = scores.copy() - summary["lr_pair"] = summary["ligand"] + "→" + summary["receptor"] + summary["interaction_pair"] = summary["ligand"] + "→" + summary["receptor"] summary["sender_receiver"] = summary["sender_celltype"] + "→" + summary["receiver_celltype"] top_pairs = ( - summary.groupby("lr_pair")["LR_score"].max().sort_values(ascending=False).head(int(top_n_pairs)).index.tolist() + summary.groupby("interaction_pair")["CCI_score"].max().sort_values(ascending=False).head(int(top_n_pairs)).index.tolist() ) - summary_matrix = summary.loc[summary["lr_pair"].isin(top_pairs)].pivot_table( - index="lr_pair", + summary_matrix = summary.loc[summary["interaction_pair"].isin(top_pairs)].pivot_table( + index="interaction_pair", columns="sender_receiver", - values="LR_score", + values="CCI_score", aggfunc="max", fill_value=0.0, ) if not summary_matrix.empty: - output_files["lr_summary_heatmap"] = save_matrix_heatmap( + output_files["cci_summary_heatmap"] = save_matrix_heatmap( summary_matrix, - title="Ligand-receptor topology summary", - output_prefix=figures_dir / "lr_summary_heatmap", + title="Cell-cell interaction topology summary", + output_prefix=figures_dir / "cci_summary_heatmap", cmap="magma", ) @@ -285,13 +285,13 @@ def ligand_receptor_topology_analysis( x_col=x_col, y_col=y_col, ) - hotspot_csv = figures_dir / "lr_hotspot_cells.csv" + hotspot_csv = figures_dir / "cci_hotspot_cells.csv" hotspot_table.to_csv(hotspot_csv, index=False) - output_files["lr_hotspot_cells_csv"] = str(hotspot_csv) - hotspot_parquet = figures_dir / "lr_hotspot_cells.parquet" + output_files["cci_hotspot_cells_csv"] = str(hotspot_csv) + hotspot_parquet = figures_dir / "cci_hotspot_cells.parquet" if safe_to_parquet(hotspot_table, hotspot_parquet): - output_files["lr_hotspot_cells_parquet"] = str(hotspot_parquet) - output_files["lr_hotspot_overlay"] = save_hotspot_overlay( + output_files["cci_hotspot_cells_parquet"] = str(hotspot_parquet) + output_files["cci_hotspot_overlay"] = save_hotspot_overlay( reference, x_col=x_col, y_col=y_col, @@ -300,7 +300,7 @@ def ligand_receptor_topology_analysis( sender_score=ligand_cell, receiver_score=receptor_cell, title=f"{best_ligand}→{best_receptor} hotspot ({best_sender}→{best_receiver})", - output_prefix=figures_dir / "lr_hotspot_overlay", + output_prefix=figures_dir / "cci_hotspot_overlay", ) return { @@ -314,4 +314,4 @@ def ligand_receptor_topology_analysis( } -__all__ = ["ligand_receptor_topology_analysis"] +__all__ = ["cci_topology_analysis"] diff --git a/src/pyXenium/contour/_feature_table.py b/src/pyXenium/contour/_feature_table.py index 0b2079e..1030763 100644 --- a/src/pyXenium/contour/_feature_table.py +++ b/src/pyXenium/contour/_feature_table.py @@ -21,7 +21,7 @@ _polygon_mask_for_bbox, ) -__all__ = ["DEFAULT_CONTOUR_LR_PAIRS", "DEFAULT_CONTOUR_PATHWAYS", "build_contour_feature_table"] +__all__ = ["DEFAULT_CONTOUR_CCI_PAIRS", "DEFAULT_CONTOUR_PATHWAYS", "build_contour_feature_table"] _DEFAULT_NEIGHBOR_K = 6 _DEFAULT_IMAGE_KEY = "he" @@ -40,7 +40,7 @@ "hypoxia_necrosis": ["CA9", "ENO1", "LDHA", "HILPDA", "SLC2A1"], } -DEFAULT_CONTOUR_LR_PAIRS: dict[str, tuple[str, str]] = { +DEFAULT_CONTOUR_CCI_PAIRS: dict[str, tuple[str, str]] = { "spp1_cd44": ("SPP1", "CD44"), "cxcl13_cxcr5": ("CXCL13", "CXCR5"), "cxcl12_cxcr4": ("CXCL12", "CXCR4"), @@ -127,7 +127,7 @@ def build_contour_feature_table( rna_rows: list[dict[str, Any]] = [] protein_rows: list[dict[str, Any]] = [] pathway_rows: list[dict[str, Any]] = [] - lr_rows: list[dict[str, Any]] = [] + cci_rows: list[dict[str, Any]] = [] embedding_rows: list[dict[str, Any]] = [] context_features = _compute_contour_context_features( @@ -264,20 +264,20 @@ def build_contour_feature_table( protein_rows.append(protein_row) pathway_rows.append(pathway_row) - lr_row = { + cci_row = { "sample_id": sample_id, "contour_key": contour_key, "contour_id": contour_id, } - lr_row.update( - _ligand_receptor_features( + cci_row.update( + _cci_features( expression=expression, inner_mask=zone_memberships["inner_rim"], outer_mask=zone_memberships["outer_rim"], ) ) - lr_rows.append(lr_row) - row.update({f"lr__{key}": value for key, value in lr_row.items() if key not in {"sample_id", "contour_key", "contour_id"}}) + cci_rows.append(cci_row) + row.update({f"cci__{key}": value for key, value in cci_row.items() if key not in {"sample_id", "contour_key", "contour_id"}}) contour_gradients = edge_gradients.loc[edge_gradients["contour_id"] == contour_id] if not contour_gradients.empty: @@ -297,7 +297,7 @@ def build_contour_feature_table( rna_pseudobulk = pd.DataFrame(rna_rows).sort_values("contour_id", kind="stable").reset_index(drop=True) protein_summary = pd.DataFrame(protein_rows).sort_values("contour_id", kind="stable").reset_index(drop=True) pathway_summary = pd.DataFrame(pathway_rows).sort_values("contour_id", kind="stable").reset_index(drop=True) - ligand_receptor_summary = pd.DataFrame(lr_rows).sort_values("contour_id", kind="stable").reset_index(drop=True) + cci_summary = pd.DataFrame(cci_rows).sort_values("contour_id", kind="stable").reset_index(drop=True) embedding_summary = ( pd.DataFrame(embedding_rows).sort_values("contour_id", kind="stable").reset_index(drop=True) if embedding_rows @@ -314,7 +314,7 @@ def build_contour_feature_table( "rna_pseudobulk": rna_pseudobulk, "protein_summary": protein_summary, "pathway_activity": pathway_summary, - "ligand_receptor_summary": ligand_receptor_summary, + "cci_summary": cci_summary, "edge_gradients": edge_gradients, "embedding_summary": embedding_summary, "available_states": state_categories, @@ -329,7 +329,7 @@ def build_contour_feature_table( "rna": [column for column in contour_features.columns if column.startswith("rna__")], "edge_contrast": [column for column in contour_features.columns if column.startswith("edge_contrast__")], "gradient": [column for column in contour_features.columns if column.startswith("gradient__")], - "ligand_receptor": [column for column in contour_features.columns if column.startswith("lr__")], + "cci": [column for column in contour_features.columns if column.startswith("cci__")], "embedding": [column for column in contour_features.columns if column.startswith("embedding__")], }, "context": { @@ -462,7 +462,7 @@ def _resolve_selected_genes(adata) -> list[str]: resolved = available.get(gene.casefold()) if resolved is not None and resolved not in selected: selected.append(resolved) - for ligand, receptor in DEFAULT_CONTOUR_LR_PAIRS.values(): + for ligand, receptor in DEFAULT_CONTOUR_CCI_PAIRS.values(): for gene in (ligand, receptor): resolved = available.get(gene.casefold()) if resolved is not None and resolved not in selected: @@ -1096,7 +1096,7 @@ def _tight_crop(image: np.ndarray, mask: np.ndarray) -> np.ndarray: return image[y0:y1, x0:x1].copy() -def _ligand_receptor_features( +def _cci_features( *, expression: pd.DataFrame, inner_mask: np.ndarray, @@ -1105,7 +1105,7 @@ def _ligand_receptor_features( features: dict[str, float] = {} inner_mean = expression.loc[inner_mask].mean(axis=0) if inner_mask.any() else pd.Series(dtype=float) outer_mean = expression.loc[outer_mask].mean(axis=0) if outer_mask.any() else pd.Series(dtype=float) - for pair_name, (ligand, receptor) in DEFAULT_CONTOUR_LR_PAIRS.items(): + for pair_name, (ligand, receptor) in DEFAULT_CONTOUR_CCI_PAIRS.items(): ligand_inner = float(inner_mean.get(ligand, 0.0)) receptor_inner = float(inner_mean.get(receptor, 0.0)) ligand_outer = float(outer_mean.get(ligand, 0.0)) diff --git a/src/pyXenium/gmi/_dataset.py b/src/pyXenium/gmi/_dataset.py index d588110..f321543 100644 --- a/src/pyXenium/gmi/_dataset.py +++ b/src/pyXenium/gmi/_dataset.py @@ -24,7 +24,7 @@ "protein__": "protein", "edge_contrast__": "edge_contrast", "gradient__": "gradient", - "lr__": "ligand_receptor", + "cci__": "cci", "pathomics__": "pathomics", "embedding__": "embedding", } diff --git a/src/pyXenium/gmi/_pdc.py b/src/pyXenium/gmi/_pdc.py index 5c7e0de..edc7d9e 100644 --- a/src/pyXenium/gmi/_pdc.py +++ b/src/pyXenium/gmi/_pdc.py @@ -8,7 +8,7 @@ DEFAULT_GMI_PDC_ROOT = "/cfs/klemming/scratch/h/hutaobo/pyxenium_gmi_contour_2026-04" DEFAULT_GMI_PDC_XENIUM_ROOT = ( - "/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04/" + "/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04/" "data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs" ) DEFAULT_GMI_PDC_CONTOUR_GEOJSON = "xenium_explorer_annotations.s1_s5.generated.geojson" @@ -41,8 +41,8 @@ def validate_pdc_gmi_path_policy(*, pdc_xenium_root: str, pdc_root: str) -> dict issues.append("pdc_root should be under /cfs/klemming/scratch for PDC GMI runs.") if root.startswith("/cfs/klemming/home/"): issues.append("pdc_root must not write into the PDC home area.") - if "/pyxenium_lr_benchmark_2026-04/" in root: - issues.append("pdc_root must be separate from the LR benchmark root.") + if "/pyxenium_cci_benchmark_2026-04/" in root: + issues.append("pdc_root must be separate from the CCI benchmark root.") if root == xenium or root.startswith(xenium + "/"): issues.append("pdc_root must not be inside the read-only Xenium source cache.") return {"valid": not issues, "issues": issues, "pdc_xenium_root": xenium, "pdc_root": root} diff --git a/src/pyXenium/ligand_receptor/__init__.py b/src/pyXenium/ligand_receptor/__init__.py deleted file mode 100644 index 684c53b..0000000 --- a/src/pyXenium/ligand_receptor/__init__.py +++ /dev/null @@ -1,5 +0,0 @@ -from __future__ import annotations - -from ._analysis import ligand_receptor_topology_analysis - -__all__ = ["ligand_receptor_topology_analysis"] diff --git a/src/pyXenium/multimodal/contour_boundary_ecology.py b/src/pyXenium/multimodal/contour_boundary_ecology.py index 454293b..bd11426 100644 --- a/src/pyXenium/multimodal/contour_boundary_ecology.py +++ b/src/pyXenium/multimodal/contour_boundary_ecology.py @@ -11,7 +11,7 @@ from sklearn.preprocessing import StandardScaler from pyXenium.contour import build_contour_feature_table -from pyXenium.contour._feature_table import DEFAULT_CONTOUR_LR_PAIRS, DEFAULT_CONTOUR_PATHWAYS +from pyXenium.contour._feature_table import DEFAULT_CONTOUR_CCI_PAIRS, DEFAULT_CONTOUR_PATHWAYS from pyXenium.io.sdata_model import XeniumSData __all__ = ["DEFAULT_BOUNDARY_PROGRAM_LIBRARY", "score_contour_boundary_programs"] @@ -30,7 +30,7 @@ "edge_contrast__omics__state_fraction__b_plasma_like": 0.8, "edge_contrast__omics__niche_fraction__immune_rich": 1.0, "edge_contrast__pathway__immune_activation": 1.0, - "lr__cxcl13_cxcr5__outer_minus_inner": 0.6, + "cci__cxcl13_cxcr5__outer_minus_inner": 0.6, }, "spatial": { "gradient__immune__outer_minus_inner": 1.2, @@ -49,8 +49,8 @@ "omics__outer_rim__state_fraction__endothelial_perivascular": 1.2, "pathway__outer_rim__myeloid_activation": 1.0, "pathway__outer_rim__vascular_stromal": 1.0, - "lr__spp1_cd44__cross_zone": 0.7, - "lr__vegfa_kdr__cross_zone": 0.7, + "cci__spp1_cd44__cross_zone": 0.7, + "cci__vegfa_kdr__cross_zone": 0.7, }, "spatial": { "gradient__myeloid__outer_minus_inner": 1.0, @@ -105,7 +105,7 @@ "omics__outer_rim__state_fraction__b_plasma_like": 1.1, "omics__outer_rim__state_fraction__t_cell_exhausted_cytotoxic": 0.9, "pathway__outer_rim__tls_activation": 1.1, - "lr__cxcl13_cxcr5__cross_zone": 0.8, + "cci__cxcl13_cxcr5__cross_zone": 0.8, }, "spatial": { "gradient__immune__outer_minus_inner": 0.8, @@ -297,7 +297,7 @@ def associate_contour_image_omics( ) omics_columns = _select_columns( merged, - prefixes=("omics__", "pathway__", "protein__", "rna__", "gradient__", "lr__", "edge_contrast__omics__", "edge_contrast__pathway__"), + prefixes=("omics__", "pathway__", "protein__", "rna__", "gradient__", "cci__", "edge_contrast__omics__", "edge_contrast__pathway__"), ) correlation_rows: list[dict[str, Any]] = [] for image_column in image_columns: @@ -421,7 +421,7 @@ def _select_model_features(frame: pd.DataFrame) -> pd.DataFrame: "protein__whole__", "rna__whole__", "gradient__", - "lr__", + "cci__", "edge_contrast__", ), ) + list(DEFAULT_BOUNDARY_PROGRAM_LIBRARY) @@ -546,12 +546,12 @@ def _program_feature_delta_table( contour_index = merged.set_index("contour_id", drop=False) rna = feature_table["rna_pseudobulk"].set_index("contour_id", drop=False) pathways = feature_table["pathway_activity"].set_index("contour_id", drop=False) - lr = feature_table["ligand_receptor_summary"].set_index("contour_id", drop=False) + cci = feature_table["cci_summary"].set_index("contour_id", drop=False) tables = [ ("gene", rna), ("pathway", pathways), - ("marker_pair", lr), + ("marker_pair", cci), ] rows: list[dict[str, Any]] = [] for program_name, program_matches in matched_exemplars.groupby("program", sort=False, dropna=False): diff --git a/src/pyXenium/validation/__init__.py b/src/pyXenium/validation/__init__.py index 3877571..01f5175 100644 --- a/src/pyXenium/validation/__init__.py +++ b/src/pyXenium/validation/__init__.py @@ -22,7 +22,7 @@ DEFAULT_ATERA_WTA_BREAST_DATASET_PATH, DEFAULT_ATERA_WTA_BREAST_SAMPLE_ID, DEFAULT_ATERA_WTA_BREAST_TBC_SUBDIR, - DEFAULT_LR_SMOKE_PANEL, + DEFAULT_CCI_SMOKE_PANEL, DEFAULT_PATHWAY_PANEL, build_serializable_breast_topology_summary, render_atera_wta_breast_topology_report, @@ -120,7 +120,7 @@ def __getattr__(name: str): "DEFAULT_ATERA_WTA_BREAST_SAMPLE_ID", "DEFAULT_ATERA_WTA_BREAST_TBC_SUBDIR", "DEFAULT_DATASET_PATH", - "DEFAULT_LR_SMOKE_PANEL", + "DEFAULT_CCI_SMOKE_PANEL", "DEFAULT_PATHWAY_PANEL", "EXPECTED_CELLS", "EXPECTED_PROTEIN_MARKERS", diff --git a/src/pyXenium/validation/atera_wta_breast_topology.py b/src/pyXenium/validation/atera_wta_breast_topology.py index d5de578..9a379c9 100644 --- a/src/pyXenium/validation/atera_wta_breast_topology.py +++ b/src/pyXenium/validation/atera_wta_breast_topology.py @@ -7,8 +7,7 @@ import pandas as pd -from pyXenium.io import read_xenium -from pyXenium.ligand_receptor import ligand_receptor_topology_analysis +from pyXenium.cci import cci_topology_analysis from pyXenium.pathway import pathway_topology_analysis DEFAULT_ATERA_WTA_BREAST_DATASET_PATH = ( @@ -18,7 +17,7 @@ DEFAULT_ATERA_WTA_BREAST_CELL_GROUPS = "WTA_Preview_FFPE_Breast_Cancer_cell_groups.csv" DEFAULT_ATERA_WTA_BREAST_SAMPLE_ID = "atera_wta_ffpe_breast" -DEFAULT_LR_SMOKE_PANEL = pd.DataFrame( +DEFAULT_CCI_SMOKE_PANEL = pd.DataFrame( [ {"ligand": "CSF1", "receptor": "CSF1R", "evidence_weight": 1.0}, {"ligand": "CXCL12", "receptor": "CXCR4", "evidence_weight": 1.0}, @@ -51,6 +50,8 @@ def _default_tbc_results_path(dataset_root: str | Path) -> Path: def _load_atera_wta_breast_adata(dataset_root: str | Path): + from pyXenium.io import read_xenium + return read_xenium( str(dataset_root), as_="anndata", @@ -99,7 +100,7 @@ def _cluster_counts(adata) -> pd.DataFrame: return pd.DataFrame({"cluster": counts.index.astype(str), "n_cells": counts.to_numpy(dtype=int)}) -def _lr_pair_summary(scores: pd.DataFrame, ligand: str, receptor: str) -> dict[str, Any]: +def _cci_pair_summary(scores: pd.DataFrame, ligand: str, receptor: str) -> dict[str, Any]: pair_scores = scores.loc[(scores["ligand"] == ligand) & (scores["receptor"] == receptor)].copy() if pair_scores.empty: return { @@ -110,7 +111,7 @@ def _lr_pair_summary(scores: pd.DataFrame, ligand: str, receptor: str) -> dict[s "best_score": None, "top_rows": [], } - pair_scores = pair_scores.sort_values("LR_score", ascending=False).reset_index(drop=True) + pair_scores = pair_scores.sort_values("CCI_score", ascending=False).reset_index(drop=True) best = pair_scores.iloc[0] top_rows = [] for _, row in pair_scores.head(5).iterrows(): @@ -118,7 +119,7 @@ def _lr_pair_summary(scores: pd.DataFrame, ligand: str, receptor: str) -> dict[s { "sender_celltype": str(row["sender_celltype"]), "receiver_celltype": str(row["receiver_celltype"]), - "LR_score": float(row["LR_score"]), + "CCI_score": float(row["CCI_score"]), } ) return { @@ -126,7 +127,7 @@ def _lr_pair_summary(scores: pd.DataFrame, ligand: str, receptor: str) -> dict[s "receptor": receptor, "best_sender_celltype": str(best["sender_celltype"]), "best_receiver_celltype": str(best["receiver_celltype"]), - "best_score": float(best["LR_score"]), + "best_score": float(best["CCI_score"]), "top_rows": top_rows, } @@ -134,18 +135,18 @@ def _lr_pair_summary(scores: pd.DataFrame, ligand: str, receptor: str) -> dict[s def _rank_of_pair(pair_scores: pd.DataFrame, sender: str, receiver: str) -> int | None: if pair_scores.empty: return None - ranked = pair_scores.sort_values("LR_score", ascending=False).reset_index(drop=True) + ranked = pair_scores.sort_values("CCI_score", ascending=False).reset_index(drop=True) matches = ranked.index[(ranked["sender_celltype"] == sender) & (ranked["receiver_celltype"] == receiver)] if len(matches) == 0: return None return int(matches[0]) + 1 -def _build_lr_acceptance(scores: pd.DataFrame) -> list[dict[str, Any]]: +def _build_cci_acceptance(scores: pd.DataFrame) -> list[dict[str, Any]]: checks: list[dict[str, Any]] = [] csf1 = scores.loc[(scores["ligand"] == "CSF1") & (scores["receptor"] == "CSF1R")].copy() - csf1 = csf1.sort_values("LR_score", ascending=False).reset_index(drop=True) + csf1 = csf1.sort_values("CCI_score", ascending=False).reset_index(drop=True) csf1_sender = str(csf1.iloc[0]["sender_celltype"]) if not csf1.empty else None checks.append( { @@ -170,7 +171,7 @@ def _build_lr_acceptance(scores: pd.DataFrame) -> list[dict[str, Any]]: ) dll4 = scores.loc[(scores["ligand"] == "DLL4") & (scores["receptor"] == "NOTCH3")].copy() - dll4 = dll4.sort_values("LR_score", ascending=False).reset_index(drop=True) + dll4 = dll4.sort_values("CCI_score", ascending=False).reset_index(drop=True) if dll4.empty: dll4_sender = None dll4_receiver = None @@ -247,15 +248,15 @@ def _build_pathway_acceptance(pathway_to_cell: pd.DataFrame) -> list[dict[str, A def build_serializable_breast_topology_summary(study: dict) -> dict[str, Any]: adata = study["adata"] cluster_counts = _cluster_counts(adata) - lr_scores = study["lr"]["scores"] + cci_scores = study["cci"]["scores"] pathway_to_cell = study["pathway"]["pathway_to_cell"] pathway_activity_to_cell = study["pathway"]["pathway_activity_to_cell"] metrics_summary = _load_metrics_summary(Path(study["dataset_root"])) experiment_metadata = _load_experiment_metadata(Path(study["dataset_root"])) - lr_pair_summaries = [ - _lr_pair_summary(lr_scores, ligand=row["ligand"], receptor=row["receptor"]) - for _, row in DEFAULT_LR_SMOKE_PANEL.iterrows() + cci_pair_summaries = [ + _cci_pair_summary(cci_scores, ligand=row["ligand"], receptor=row["receptor"]) + for _, row in DEFAULT_CCI_SMOKE_PANEL.iterrows() ] payload = { @@ -271,12 +272,12 @@ def build_serializable_breast_topology_summary(study: dict) -> dict[str, Any]: "cluster_cell_counts": cluster_counts.to_dict(orient="records"), "metrics_summary": metrics_summary, "experiment_metadata": experiment_metadata, - "lr_smoke_panel": DEFAULT_LR_SMOKE_PANEL.to_dict(orient="records"), + "cci_smoke_panel": DEFAULT_CCI_SMOKE_PANEL.to_dict(orient="records"), "pathway_smoke_panel": [ {"pathway": pathway, "genes": genes} for pathway, genes in DEFAULT_PATHWAY_PANEL.items() ], - "lr_pair_summaries": lr_pair_summaries, - "lr_acceptance": _build_lr_acceptance(lr_scores), + "cci_pair_summaries": cci_pair_summaries, + "cci_acceptance": _build_cci_acceptance(cci_scores), "pathway_primary_best": _pathway_best_assignments(pathway_to_cell), "pathway_activity_best": _pathway_best_assignments(pathway_activity_to_cell), "pathway_acceptance": _build_pathway_acceptance(pathway_to_cell), @@ -305,11 +306,11 @@ def render_atera_wta_breast_topology_report(payload: dict) -> str: f"- median_transcripts_per_cell: `{payload['metrics_summary'].get('median_transcripts_per_cell')}`", f"- Runtime (s): `{payload['runtime_seconds']:.2f}`", "", - "## LR Smoke Panel", + "## CCI Smoke Panel", "", ] - for entry in payload["lr_pair_summaries"]: + for entry in payload["cci_pair_summaries"]: ligand = entry["ligand"] receptor = entry["receptor"] best_sender = entry["best_sender_celltype"] @@ -320,8 +321,8 @@ def render_atera_wta_breast_topology_report(payload: dict) -> str: + (f" (`{best_score:.4f}`)" if best_score is not None else "") ) - lines.extend(["", "## LR Acceptance", ""]) - for check in payload["lr_acceptance"]: + lines.extend(["", "## CCI Acceptance", ""]) + for check in payload["cci_acceptance"]: status = "PASS" if check["pass"] else "FAIL" lines.append(f"- `{status}` {check['check']}") @@ -379,9 +380,9 @@ def run_atera_wta_breast_topology( adata = _load_atera_wta_breast_adata(dataset_root_path) - lr_result = ligand_receptor_topology_analysis( + cci_result = cci_topology_analysis( adata=adata, - lr_pairs=DEFAULT_LR_SMOKE_PANEL, + interaction_pairs=DEFAULT_CCI_SMOKE_PANEL, output_dir=resolved_output_dir, tbc_results=resolved_tbc_results, cluster_col="cluster", @@ -389,7 +390,7 @@ def run_atera_wta_breast_topology( x_col="x", y_col="y", anchor_mode="precomputed", - top_n_pairs=len(DEFAULT_LR_SMOKE_PANEL), + top_n_pairs=len(DEFAULT_CCI_SMOKE_PANEL), min_cross_edges=50, export_figures=export_figures, ) @@ -415,7 +416,7 @@ def run_atera_wta_breast_topology( runtime_seconds = time.perf_counter() - start merged_files = {} - merged_files.update(lr_result.get("files", {})) + merged_files.update(cci_result.get("files", {})) merged_files.update(pathway_result.get("files", {})) study = { @@ -423,7 +424,7 @@ def run_atera_wta_breast_topology( "dataset_root": str(dataset_root_path), "tbc_results": str(resolved_tbc_results), "adata": adata, - "lr": lr_result, + "cci": cci_result, "pathway": pathway_result, "files": merged_files, "runtime_seconds": runtime_seconds, @@ -455,7 +456,7 @@ def run_atera_wta_breast_topology( "DEFAULT_ATERA_WTA_BREAST_DATASET_PATH", "DEFAULT_ATERA_WTA_BREAST_SAMPLE_ID", "DEFAULT_ATERA_WTA_BREAST_TBC_SUBDIR", - "DEFAULT_LR_SMOKE_PANEL", + "DEFAULT_CCI_SMOKE_PANEL", "DEFAULT_PATHWAY_PANEL", "build_serializable_breast_topology_summary", "render_atera_wta_breast_topology_report", diff --git a/tests/test_lr_benchmark_cli.py b/tests/test_cci_benchmark_cli.py similarity index 90% rename from tests/test_lr_benchmark_cli.py rename to tests/test_cci_benchmark_cli.py index e0ab7df..e1ac060 100644 --- a/tests/test_lr_benchmark_cli.py +++ b/tests/test_cci_benchmark_cli.py @@ -17,22 +17,22 @@ def _write_adapter_dry_run_fixture(tmp_path: Path) -> Path: - slug: squidpy display_name: Squidpy ligrec language: python - env_name: pyx-lr-squidpy + env_name: pyx-cci-squidpy runner: runners/python/run_squidpy.py - slug: liana display_name: LIANA+ bivariate language: python - env_name: pyx-lr-liana + env_name: pyx-cci-liana runner: runners/python/run_liana.py - slug: commot display_name: COMMOT language: python - env_name: pyx-lr-commot + env_name: pyx-cci-commot runner: runners/python/run_commot.py - slug: cellchat display_name: CellChat v3 / Spatial CellChat language: r - env_name: r-lr-cellchat + env_name: r-cci-cellchat runner: runners/r/run_cellchat.R """ (benchmark / "configs" / "methods.yaml").write_text(methods_yaml, encoding="utf-8") @@ -46,16 +46,16 @@ def _write_adapter_dry_run_fixture(tmp_path: Path) -> Path: (tmp_path / "README.md").write_text("toy\n", encoding="utf-8") (tmp_path / "LICENSE").write_text("toy\n", encoding="utf-8") (tmp_path / "src").mkdir(exist_ok=True) - lr_db = benchmark / "data" / "lr_db_common.tsv" + cci_resource = benchmark / "data" / "cci_resource_common.tsv" smoke_panel = benchmark / "data" / "atera_smoke_panel.tsv" (benchmark / "data" / "smoke").mkdir() (benchmark / "data" / "smoke" / "adata_smoke.h5ad").touch() - lr_db.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") + cci_resource.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") smoke_panel.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") manifest = { "smoke_h5ad": str(benchmark / "data" / "smoke" / "adata_smoke.h5ad"), "full_h5ad": None, - "lr_db_common_tsv": str(lr_db), + "cci_resource_common_tsv": str(cci_resource), "atera_smoke_panel_tsv": str(smoke_panel), "smoke_bundle": {}, "full_bundle": {"counts_symbol_mtx": str(benchmark / "data" / "full" / "counts_symbol.mtx")}, @@ -67,7 +67,7 @@ def _write_adapter_dry_run_fixture(tmp_path: Path) -> Path: def test_benchmark_prepare_command(monkeypatch, tmp_path): captured = {} - def fake_prepare_atera_lr_benchmark(**kwargs): + def fake_prepare_atera_cci_benchmark(**kwargs): captured.update(kwargs) return { "dataset_root": kwargs["dataset_root"], @@ -75,13 +75,13 @@ def fake_prepare_atera_lr_benchmark(**kwargs): "smoke_n_cells": kwargs["smoke_n_cells"], } - monkeypatch.setattr("pyXenium.__main__.prepare_atera_lr_benchmark", fake_prepare_atera_lr_benchmark) + monkeypatch.setattr("pyXenium.__main__.prepare_atera_cci_benchmark", fake_prepare_atera_cci_benchmark) result = CliRunner().invoke( app, [ "benchmark", - "atera-lr", + "atera-cci", "prepare", "--dataset-root", str(tmp_path / "dataset"), @@ -102,7 +102,7 @@ def fake_prepare_atera_lr_benchmark(**kwargs): def test_benchmark_prepare_command_accepts_xenium_root_alias(monkeypatch, tmp_path): captured = {} - def fake_prepare_atera_lr_benchmark(**kwargs): + def fake_prepare_atera_cci_benchmark(**kwargs): captured.update(kwargs) return { "dataset_root": kwargs["dataset_root"], @@ -110,13 +110,13 @@ def fake_prepare_atera_lr_benchmark(**kwargs): "smoke_n_cells": kwargs["smoke_n_cells"], } - monkeypatch.setattr("pyXenium.__main__.prepare_atera_lr_benchmark", fake_prepare_atera_lr_benchmark) + monkeypatch.setattr("pyXenium.__main__.prepare_atera_cci_benchmark", fake_prepare_atera_cci_benchmark) result = CliRunner().invoke( app, [ "benchmark", - "atera-lr", + "atera-cci", "prepare", "--xenium-root", str(tmp_path / "dataset"), @@ -163,7 +163,7 @@ def fake_run_pyxenium_smoke(**kwargs): app, [ "benchmark", - "atera-lr", + "atera-cci", "smoke-pyxenium", "--benchmark-root", str(tmp_path / "benchmark"), @@ -209,13 +209,13 @@ def fake_resolve_layout(*, relative_root): monkeypatch.setattr("pyXenium.__main__.compute_novelty_support", lambda combined: (None, pd.DataFrame([{"method": "pyxenium", "database_mode": "common-db", "novelty_support_score": 0.0}]))) monkeypatch.setattr("pyXenium.__main__.compute_robustness", lambda combined: pd.DataFrame([{"method": "pyxenium", "database_mode": "common-db", "robustness_score": 0.0}])) monkeypatch.setattr("pyXenium.__main__.score_biological_performance", lambda **kwargs: pd.DataFrame([{"method": "pyxenium", "database_mode": "common-db", "biology_score": 0.75, "spatial_coherence_score": 1.0}])) - monkeypatch.setattr("pyXenium.__main__.render_atera_lr_benchmark_report", lambda **kwargs: "# report\n") + monkeypatch.setattr("pyXenium.__main__.render_atera_cci_benchmark_report", lambda **kwargs: "# report\n") result = CliRunner().invoke( app, [ "benchmark", - "atera-lr", + "atera-cci", "report", "--benchmark-root", str(tmp_path / "benchmark"), @@ -238,14 +238,14 @@ def test_benchmark_run_method_dry_run_command(tmp_path): app, [ "benchmark", - "atera-lr", + "atera-cci", "run-method", "--method", "squidpy", "--benchmark-root", str(benchmark), "--dry-run", - "--max-lr-pairs", + "--max-cci-pairs", "1", ], ) @@ -254,7 +254,7 @@ def test_benchmark_run_method_dry_run_command(tmp_path): payload = json.loads(result.output) assert payload["method"] == "squidpy" assert payload["will_execute"] is True - assert payload["lr_pairs"] == 1 + assert payload["interaction_pairs"] == 1 assert payload["output_dir"].endswith("squidpy_smoke_common_db") @@ -265,7 +265,7 @@ def test_benchmark_run_method_dry_run_accepts_chunk_and_gzip_options(tmp_path): app, [ "benchmark", - "atera-lr", + "atera-cci", "run-method", "--method", "commot", @@ -300,14 +300,14 @@ def test_benchmark_smoke_core_dry_run_command(tmp_path): app, [ "benchmark", - "atera-lr", + "atera-cci", "smoke-core", "--benchmark-root", str(benchmark), "--methods", "squidpy,liana,commot,cellchat", "--dry-run", - "--max-lr-pairs", + "--max-cci-pairs", "1", ], ) @@ -327,7 +327,7 @@ def test_benchmark_stage_a100_plan_only_command(tmp_path, monkeypatch): app, [ "benchmark", - "atera-lr", + "atera-cci", "stage-a100", "--benchmark-root", str(benchmark), @@ -357,7 +357,7 @@ def test_benchmark_prepare_a100_bundle_command(tmp_path, monkeypatch): app, [ "benchmark", - "atera-lr", + "atera-cci", "prepare-a100-bundle", "--benchmark-root", str(benchmark), @@ -403,7 +403,7 @@ def test_benchmark_run_a100_plan_dry_run_command(tmp_path): app, [ "benchmark", - "atera-lr", + "atera-cci", "run-a100-plan", "--plan-json", str(plan), @@ -431,7 +431,7 @@ def test_benchmark_collect_a100_results_dry_run_command(tmp_path, monkeypatch): app, [ "benchmark", - "atera-lr", + "atera-cci", "collect-a100-results", "--benchmark-root", str(benchmark), @@ -459,7 +459,7 @@ def test_benchmark_a100_matrix_submit_monitor_finalize_commands(tmp_path, monkey app, [ "benchmark", - "atera-lr", + "atera-cci", "build-a100-matrix", "--benchmark-root", str(benchmark), @@ -487,7 +487,7 @@ def test_benchmark_a100_matrix_submit_monitor_finalize_commands(tmp_path, monkey app, [ "benchmark", - "atera-lr", + "atera-cci", "submit-a100-matrix", "--matrix-json", str(matrix_json), @@ -509,7 +509,7 @@ def test_benchmark_a100_matrix_submit_monitor_finalize_commands(tmp_path, monkey app, [ "benchmark", - "atera-lr", + "atera-cci", "monitor-a100-jobs", "--matrix-json", str(matrix_json), @@ -526,7 +526,7 @@ def test_benchmark_a100_matrix_submit_monitor_finalize_commands(tmp_path, monkey app, [ "benchmark", - "atera-lr", + "atera-cci", "finalize-a100-all", "--benchmark-root", str(benchmark), @@ -546,7 +546,7 @@ def test_benchmark_build_a100_sidecar_command(tmp_path, monkeypatch): app, [ "benchmark", - "atera-lr", + "atera-cci", "build-a100-sidecar", "--benchmark-root", str(benchmark), @@ -566,3 +566,25 @@ def test_benchmark_build_a100_sidecar_command(tmp_path, monkeypatch): assert payload["ready_methods"] == ["squidpy"] assert any(job["job_id"] == "sidecar_smoke_common_db_squidpy" for job in payload["jobs"]) assert not any(job["method"] == "cellchat" for job in payload["jobs"]) + + +def test_benchmark_finalize_source_of_truth_command(tmp_path, monkeypatch): + benchmark = _write_adapter_dry_run_fixture(tmp_path) + monkeypatch.chdir(tmp_path) + + result = CliRunner().invoke( + app, + [ + "benchmark", + "atera-cci", + "finalize-source-of-truth", + "--benchmark-root", + str(benchmark), + "--skip-report", + ], + ) + + assert result.exit_code == 0 + payload = json.loads(result.output) + assert payload["kind"] == "cci_source_of_truth_finalize" + assert payload["n_rows"] == 0 diff --git a/tests/test_lr_benchmarking.py b/tests/test_cci_benchmarking.py similarity index 80% rename from tests/test_lr_benchmarking.py rename to tests/test_cci_benchmarking.py index 149bc68..c7961f5 100644 --- a/tests/test_lr_benchmarking.py +++ b/tests/test_cci_benchmarking.py @@ -11,7 +11,7 @@ from scipy import sparse from scipy.io import mmwrite -from pyXenium.benchmarking.lr_atera import ( +from pyXenium.benchmarking.cci_atera import ( STANDARDIZED_RESULT_COLUMNS, aggregate_standardized_results, compute_canonical_recovery, @@ -20,12 +20,12 @@ compute_robustness, compute_spatial_coherence, harmonize_adata_for_benchmark, - prepare_atera_lr_benchmark, - render_atera_lr_benchmark_report, + prepare_atera_cci_benchmark, + render_atera_cci_benchmark_report, score_biological_performance, standardize_result_table, ) -from pyXenium.benchmarking.lr_a100 import ( +from pyXenium.benchmarking.cci_a100 import ( DEFAULT_A100_READONLY_XENIUM_ROOT, build_a100_job_matrix, build_a100_job_manifest, @@ -35,6 +35,7 @@ collect_a100_results, execute_a100_stage_plan, finalize_a100_all, + finalize_cci_source_of_truth, monitor_a100_jobs, prepare_a100_bundle, run_a100_plan, @@ -43,14 +44,14 @@ validate_a100_path_policy, write_failed_method_card, ) -from pyXenium.benchmarking.lr_adapters import ( +from pyXenium.benchmarking.cci_adapters import ( _call_liana_bivariate, aggregate_commot_obsp_result, aggregate_liana_bivariate_result, estimate_commot_distance_threshold, ensure_categorical_obs, ensure_spatial_connectivities, - flatten_squidpy_ligrec_result, + flatten_squidpy_cci_result, read_sparse_bundle_as_adata, validate_input_manifest, ) @@ -93,6 +94,32 @@ def _toy_adata() -> ad.AnnData: return adata +def _write_standardized_result(path: Path, *, method: str, ligand: str = "CXCL12", receptor: str = "CXCR4") -> Path: + path.parent.mkdir(parents=True, exist_ok=True) + row = { + "method": method, + "database_mode": "common-db", + "ligand": ligand, + "receptor": receptor, + "sender": "A", + "receiver": "B", + "score_raw": 1.0, + "score_std": 1.0, + "rank_within_method": 1, + "rank_fraction": 1.0, + "fdr_or_pvalue": np.nan, + "resolution": "celltype_pair", + "spatial_support_type": "test", + "artifact_path": str(path.parent), + } + pd.DataFrame([row], columns=STANDARDIZED_RESULT_COLUMNS).to_csv(path, sep="\t", index=False) + (path.parent / "run_summary.json").write_text( + json.dumps({"method": method, "status": "success", "n_rows": 1, "standardized_tsv": str(path)}), + encoding="utf-8", + ) + return path + + def test_harmonize_adata_for_benchmark_promotes_gene_symbols_and_spatial_coords(): bench = harmonize_adata_for_benchmark(_toy_adata()) @@ -104,10 +131,10 @@ def test_harmonize_adata_for_benchmark_promotes_gene_symbols_and_spatial_coords( assert list(bench.var["ensembl_id"]) == ["ENSG1", "ENSG2", "ENSG3"] -def test_prepare_atera_lr_benchmark_writes_sparse_bundle_and_manifest(monkeypatch, tmp_path): +def test_prepare_atera_cci_benchmark_writes_sparse_bundle_and_manifest(monkeypatch, tmp_path): monkeypatch.setattr("pyXenium.io.read_xenium", lambda *args, **kwargs: _toy_adata()) - payload = prepare_atera_lr_benchmark( + payload = prepare_atera_cci_benchmark( dataset_root=tmp_path / "dataset", benchmark_root=tmp_path / "benchmark", tbc_results=tmp_path / "dataset" / "results", @@ -119,7 +146,7 @@ def test_prepare_atera_lr_benchmark_writes_sparse_bundle_and_manifest(monkeypatc manifest_path = tmp_path / "benchmark" / "data" / "input_manifest.json" full_h5ad = tmp_path / "benchmark" / "data" / "full" / "adata_full.h5ad" smoke_h5ad = tmp_path / "benchmark" / "data" / "smoke" / "adata_smoke.h5ad" - common_db = tmp_path / "benchmark" / "data" / "lr_db_common.tsv" + common_db = tmp_path / "benchmark" / "data" / "cci_resource_common.tsv" assert manifest_path.exists() assert full_h5ad.exists() @@ -137,10 +164,10 @@ def test_prepare_atera_lr_benchmark_writes_sparse_bundle_and_manifest(monkeypatc assert manifest["full_bundle_fingerprints"]["counts_symbol_mtx"]["exists"] is True -def test_prepare_atera_lr_benchmark_can_skip_full_h5ad_but_keep_sparse_full_bundle(monkeypatch, tmp_path): +def test_prepare_atera_cci_benchmark_can_skip_full_h5ad_but_keep_sparse_full_bundle(monkeypatch, tmp_path): monkeypatch.setattr("pyXenium.io.read_xenium", lambda *args, **kwargs: _toy_adata()) - payload = prepare_atera_lr_benchmark( + payload = prepare_atera_cci_benchmark( dataset_root=tmp_path / "dataset", benchmark_root=tmp_path / "benchmark", tbc_results=tmp_path / "dataset" / "results", @@ -189,9 +216,9 @@ def test_read_sparse_bundle_as_adata_round_trips_bundle(tmp_path): def test_validate_input_manifest_requires_full_input(tmp_path): - lr_db = tmp_path / "lr.tsv" - lr_db.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") - manifest = {"lr_db_common_tsv": str(lr_db), "smoke_h5ad": str(tmp_path / "smoke.h5ad"), "full_bundle": {}} + cci_resource = tmp_path / "cci.tsv" + cci_resource.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") + manifest = {"cci_resource_common_tsv": str(cci_resource), "smoke_h5ad": str(tmp_path / "smoke.h5ad"), "full_bundle": {}} validation = validate_input_manifest(manifest, require_full=True) @@ -207,7 +234,7 @@ def test_standardize_and_score_biological_results(): "receptor": "CXCR4", "sender_celltype": "CAFs, DCIS Associated", "receiver_celltype": "T Lymphocytes", - "LR_score": 0.8, + "CCI_score": 0.8, "local_contact": 0.5, }, { @@ -215,7 +242,7 @@ def test_standardize_and_score_biological_results(): "receptor": "TGFBR2", "sender_celltype": "Endothelial Cells", "receiver_celltype": "Endothelial Cells", - "LR_score": 0.3, + "CCI_score": 0.3, "local_contact": 0.2, }, ] @@ -315,7 +342,7 @@ def test_standardize_uses_pvalue_to_break_score_ties(): "receptor": "B", "sender_celltype": "s1", "receiver_celltype": "r1", - "LR_score": 1.0, + "CCI_score": 1.0, "pvalue": 0.05, }, { @@ -323,7 +350,7 @@ def test_standardize_uses_pvalue_to_break_score_ties(): "receptor": "D", "sender_celltype": "s1", "receiver_celltype": "r1", - "LR_score": 1.0, + "CCI_score": 1.0, "pvalue": 0.001, }, ] @@ -345,7 +372,7 @@ def test_aggregate_standardized_results_reads_gzip_outputs(tmp_path): "receptor": "CXCR4", "sender_celltype": "CAFs, DCIS Associated", "receiver_celltype": "T Lymphocytes", - "LR_score": 1.0, + "CCI_score": 1.0, } ] ), @@ -364,7 +391,7 @@ def test_aggregate_standardized_results_reads_gzip_outputs(tmp_path): assert combined.iloc[0]["method"] == "laris" -def test_flatten_squidpy_ligrec_result_handles_multiindex_columns(): +def test_flatten_squidpy_cci_result_handles_multiindex_columns(): means = pd.DataFrame( [[0.8, 0.2], [0.1, 0.5]], index=pd.Index(["CXCL12^CXCR4", "TGFB1^TGFBR2"], name="interaction"), @@ -382,10 +409,10 @@ def test_flatten_squidpy_ligrec_result_handles_multiindex_columns(): ) metadata = pd.DataFrame({"source": ["CXCL12", "TGFB1"], "target": ["CXCR4", "TGFBR2"]}, index=means.index) - flat = flatten_squidpy_ligrec_result({"means": means, "pvalues": pvalues, "metadata": metadata}) + flat = flatten_squidpy_cci_result({"means": means, "pvalues": pvalues, "metadata": metadata}) assert len(flat) == 4 - top = flat.sort_values("LR_score", ascending=False).iloc[0] + top = flat.sort_values("CCI_score", ascending=False).iloc[0] assert top["ligand"] == "CXCL12" assert top["receptor"] == "CXCR4" assert top["sender_celltype"] == "CAFs, DCIS Associated" @@ -404,9 +431,9 @@ def test_aggregate_liana_bivariate_result_uses_spatial_neighbor_mix(): flat = aggregate_liana_bivariate_result(local_scores, source) - assert {"ligand", "receptor", "sender_celltype", "receiver_celltype", "LR_score"}.issubset(flat.columns) + assert {"ligand", "receptor", "sender_celltype", "receiver_celltype", "CCI_score"}.issubset(flat.columns) assert set(flat["ligand"]) == {"CXCL12"} - assert flat["LR_score"].max() > 0 + assert flat["CCI_score"].max() > 0 def test_call_liana_bivariate_disables_raw_lookup(monkeypatch): @@ -448,15 +475,15 @@ def test_aggregate_commot_obsp_result_collapses_cell_pair_matrix(): ) ) adata.obsp["commot-pyx_common-CXCL12-CXCR4"] = matrix - lr_resource = pd.DataFrame({"ligand": ["CXCL12"], "receptor": ["CXCR4"], "pathway": ["chemokine"]}) + cci_resource = pd.DataFrame({"ligand": ["CXCL12"], "receptor": ["CXCR4"], "pathway": ["chemokine"]}) - flat = aggregate_commot_obsp_result(adata, lr_resource, database_name="pyx_common") + flat = aggregate_commot_obsp_result(adata, cci_resource, database_name="pyx_common") assert len(flat) == 1 row = flat.iloc[0] assert row["sender_celltype"] == "CAFs, DCIS Associated" assert row["receiver_celltype"] == "T Lymphocytes" - assert row["LR_score"] == 3.0 + assert row["CCI_score"] == 3.0 assert row["edge_count"] == 2.0 @@ -480,7 +507,7 @@ def test_ensure_categorical_obs_promotes_string_labels(): def test_build_a100_stage_and_job_manifest(tmp_path, monkeypatch): repo = tmp_path / "repo" - benchmark = repo / "benchmarking" / "lr_2026_atera" + benchmark = repo / "benchmarking" / "cci_2026_atera" (benchmark / "configs").mkdir(parents=True) (benchmark / "envs").mkdir() (benchmark / "scripts").mkdir() @@ -495,12 +522,12 @@ def test_build_a100_stage_and_job_manifest(tmp_path, monkeypatch): - slug: pyxenium display_name: pyXenium language: python - env_name: pyx-lr-pyxenium + env_name: pyx-cci-pyxenium runner: runners/python/run_pyxenium.py - slug: cellchat display_name: CellChat language: r - env_name: r-lr-cellchat + env_name: r-cci-cellchat runner: runners/r/run_cellchat.R """, encoding="utf-8", @@ -529,7 +556,7 @@ def test_build_a100_stage_and_job_manifest(tmp_path, monkeypatch): assert DEFAULT_A100_READONLY_XENIUM_ROOT in jobs["jobs"][0]["command"] assert 'PATH="$HOME/miniconda3/bin:$HOME/miniconda3/condabin:$PATH"' in jobs["jobs"][0]["command"] assert "PYTHONNOUSERSITE=1" in jobs["jobs"][0]["command"] - assert 'LD_LIBRARY_PATH="$HOME/miniconda3/envs/pyx-lr-prep/lib:$HOME/miniconda3/lib:${LD_LIBRARY_PATH:-}"' in jobs["jobs"][0]["command"] + assert 'LD_LIBRARY_PATH="$HOME/miniconda3/envs/pyx-cci-prep/lib:$HOME/miniconda3/lib:${LD_LIBRARY_PATH:-}"' in jobs["jobs"][0]["command"] assert "TMPDIR=/data/taobo.hu/test/tmp" in jobs["jobs"][0]["command"] assert jobs["jobs"][0]["output_dir"] == "/data/taobo.hu/test/data" assert jobs["run_group"] == "full_common" @@ -541,7 +568,7 @@ def test_build_a100_stage_and_job_manifest(tmp_path, monkeypatch): def test_build_a100_job_matrix_chunks_commot_and_assigns_gpu_slots(tmp_path, monkeypatch): repo = tmp_path / "repo" - benchmark = repo / "benchmarking" / "lr_2026_atera" + benchmark = repo / "benchmarking" / "cci_2026_atera" (benchmark / "configs").mkdir(parents=True) (benchmark / "runs").mkdir(parents=True) (benchmark / "results").mkdir(parents=True) @@ -552,18 +579,23 @@ def test_build_a100_job_matrix_chunks_commot_and_assigns_gpu_slots(tmp_path, mon - slug: commot display_name: COMMOT language: python - env_name: pyx-lr-commot + env_name: pyx-cci-commot runner: scripts/run_method.py - slug: cellnest display_name: CellNEST language: python - env_name: pyx-lr-cellnest + env_name: pyx-cci-cellnest + runner: scripts/run_method.py + - slug: cellagentchat + display_name: CellAgentChat + language: python + env_name: pyx-cci-cellagentchat runner: scripts/run_method.py - slug: giotto display_name: Giotto language: r - env_name: r-lr-giotto - runner: runners/r/run_external_lr_method.R + env_name: r-cci-giotto + runner: runners/r/run_external_cci_method.R """, encoding="utf-8", ) @@ -572,19 +604,22 @@ def test_build_a100_job_matrix_chunks_commot_and_assigns_gpu_slots(tmp_path, mon matrix = build_a100_job_matrix( benchmark_root=benchmark, remote_root="/data/taobo.hu/test", - methods=["commot", "cellnest", "giotto"], + methods=["commot", "cellnest", "cellagentchat", "giotto"], phase="full", database_mode="common-db", - max_lr_pairs=25, + max_cci_pairs=25, commot_chunks=4, + cellagentchat_chunks=4, gpu_count=8, include_bootstrap=True, include_audit=True, ) - bootstrap = next(job for job in matrix["jobs"] if job["job_id"] == "bootstrap_pyx_lr_commot") + bootstrap = next(job for job in matrix["jobs"] if job["job_id"] == "bootstrap_pyx_cci_commot") commot_jobs = [job for job in matrix["jobs"] if job["method"] == "commot" and job["job_type"] == "method_run"] cellnest_job = next(job for job in matrix["jobs"] if job["method"] == "cellnest" and job["job_type"] == "method_run") + cellagentchat_jobs = [job for job in matrix["jobs"] if job["method"] == "cellagentchat" and job["job_type"] == "method_run"] + cellagentchat_aggregate = next(job for job in matrix["jobs"] if job["job_id"] == "full_common_db_cellagentchat_aggregate") giotto_audit = next(job for job in matrix["jobs"] if job["job_id"] == "audit_giotto") assert matrix["path_policy"]["valid"] is True @@ -601,6 +636,24 @@ def test_build_a100_job_matrix_chunks_commot_and_assigns_gpu_slots(tmp_path, mon assert "OMP_NUM_THREADS=8" in commot_jobs[0]["command"] assert cellnest_job["gpu_id"] == 0 assert "CUDA_VISIBLE_DEVICES=0" in cellnest_job["command"] + assert "source_checkout_ok cellnest already at" in cellnest_job["command"] + assert len(cellagentchat_jobs) == 4 + assert {job["chunk_id"] for job in cellagentchat_jobs} == {0, 1, 2, 3} + assert all(job["num_chunks"] == 4 for job in cellagentchat_jobs) + assert "--chunk-id 0" in cellagentchat_jobs[0]["command"] + assert "--num-chunks 4" in cellagentchat_jobs[0]["command"] + assert "CELLAGENTCHAT_FEATURE_SELECTION" in cellagentchat_jobs[0]["command"] + assert "source_checkout_ok cellagentchat already at" in cellagentchat_jobs[0]["command"] + assert cellagentchat_jobs[0]["gpu_id"] == 1 + assert cellagentchat_aggregate["job_type"] == "method_aggregate" + assert cellagentchat_aggregate["output_dir"] == "/data/taobo.hu/test/runs/full_common/cellagentchat" + assert set(cellagentchat_aggregate["dependencies"]) == { + "full_common_db_cellagentchat_chunk_000_of_004", + "full_common_db_cellagentchat_chunk_001_of_004", + "full_common_db_cellagentchat_chunk_002_of_004", + "full_common_db_cellagentchat_chunk_003_of_004", + } + assert "cellagentchat_standardized.tsv.gz" in cellagentchat_aggregate["command"] assert "Rscript" in giotto_audit["command"] assert "renv::load" in giotto_audit["command"] assert "intToUtf8(10)" in giotto_audit["command"] @@ -610,7 +663,7 @@ def test_build_a100_job_matrix_chunks_commot_and_assigns_gpu_slots(tmp_path, mon def test_build_a100_sidecar_matrix_uses_distinct_outputs_and_pilot_manifest(tmp_path, monkeypatch): repo = tmp_path / "repo" - benchmark = repo / "benchmarking" / "lr_2026_atera" + benchmark = repo / "benchmarking" / "cci_2026_atera" (benchmark / "configs").mkdir(parents=True) (repo / "src").mkdir() (repo / "pyproject.toml").write_text("[project]\nname='toy'\n", encoding="utf-8") @@ -619,18 +672,18 @@ def test_build_a100_sidecar_matrix_uses_distinct_outputs_and_pilot_manifest(tmp_ - slug: spatialdm display_name: SpatialDM language: python - env_name: pyx-lr-spatialdm + env_name: pyx-cci-spatialdm runner: scripts/run_method.py - slug: cellnest display_name: CellNEST language: python - env_name: pyx-lr-cellnest + env_name: pyx-cci-cellnest runner: scripts/run_method.py - slug: giotto display_name: Giotto language: r - env_name: r-lr-giotto - runner: runners/r/run_external_lr_method.R + env_name: r-cci-giotto + runner: runners/r/run_external_cci_method.R """, encoding="utf-8", ) @@ -642,8 +695,8 @@ def test_build_a100_sidecar_matrix_uses_distinct_outputs_and_pilot_manifest(tmp_ methods=["spatialdm", "cellnest", "giotto"], ready_methods=["spatialdm", "cellnest"], completed_job_ids=["sidecar_audit_spatialdm"], - smoke_max_lr_pairs=25, - pilot_max_lr_pairs=100, + smoke_max_cci_pairs=25, + pilot_max_cci_pairs=100, gpu_start=3, ) @@ -667,6 +720,59 @@ def test_build_a100_sidecar_matrix_uses_distinct_outputs_and_pilot_manifest(tmp_ assert matrix["path_policy"]["valid"] is True +def test_finalize_cci_source_of_truth_prefers_a100_and_requires_commot_chunks(tmp_path, monkeypatch): + repo = tmp_path / "repo" + benchmark = repo / "benchmarking" / "cci_2026_atera" + (benchmark / "configs").mkdir(parents=True) + (benchmark / "runs").mkdir(parents=True) + (benchmark / "results").mkdir(parents=True) + (benchmark / "reports").mkdir(parents=True) + (repo / "pyproject.toml").write_text("[project]\nname='toy'\n", encoding="utf-8") + monkeypatch.chdir(repo) + + _write_standardized_result(benchmark / "runs" / "a100_collected" / "full_common" / "pyxenium" / "pyxenium_standardized.tsv", method="pyxenium") + _write_standardized_result( + benchmark / "pdc_collected" / "pdc_old" / "runs" / "full_common" / "pyxenium" / "pyxenium_standardized.tsv", + method="pyxenium", + ligand="OLD", + receptor="OLD", + ) + _write_standardized_result( + benchmark / "pdc_collected" / "pdc_new" / "runs" / "full_common" / "cellchat" / "cellchat_standardized.tsv", + method="cellchat", + ) + _write_standardized_result( + benchmark / "pdc_collected" / "pdc_new" / "runs" / "full_common" / "cellagentchat" / "cellagentchat_standardized.tsv", + method="cellagentchat", + ) + _write_standardized_result( + benchmark / "pdc_collected" / "pdc_new" / "runs" / "full_common" / "commot" / "chunk_000_of_002" / "commot_standardized.tsv", + method="commot", + ) + _write_standardized_result( + benchmark / "pdc_collected" / "pdc_new" / "runs" / "full_common" / "commot" / "chunk_001_of_002" / "commot_standardized.tsv", + method="commot", + ligand="DLL4", + receptor="NOTCH3", + ) + + payload = finalize_cci_source_of_truth( + benchmark_root=benchmark, + pdc_tag="pdc_new", + commot_chunks=2, + render_report=False, + ) + + assert payload["methods"] == ["cellagentchat", "cellchat", "commot", "pyxenium"] + selected_paths = payload["selection"]["input_paths"] + assert any("a100_collected" in path and "pyxenium" in path for path in selected_paths) + assert not any("pdc_old" in path for path in selected_paths) + assert len([path for path in selected_paths if "commot" in path]) == 2 + assert payload["validation"]["status"] == "passed" + combined = pd.read_csv(payload["outputs"]["combined_results"], sep="\t") + assert set(combined["method"]) == {"pyxenium", "cellchat", "commot", "cellagentchat"} + + def test_a100_path_policy_flags_write_targets_in_readonly_root(): policy = validate_a100_path_policy( { @@ -689,7 +795,7 @@ def test_a100_path_policy_flags_write_targets_in_readonly_root(): def test_prepare_a100_bundle_reports_blocked_without_full_bundle(monkeypatch, tmp_path): monkeypatch.chdir(tmp_path) - benchmark = tmp_path / "benchmarking" / "lr_2026_atera" + benchmark = tmp_path / "benchmarking" / "cci_2026_atera" (benchmark / "configs").mkdir(parents=True) (benchmark / "envs").mkdir() (benchmark / "scripts").mkdir() @@ -705,15 +811,15 @@ def test_prepare_a100_bundle_reports_blocked_without_full_bundle(monkeypatch, tm - slug: pyxenium display_name: pyXenium language: python - env_name: pyx-lr-pyxenium + env_name: pyx-cci-pyxenium runner: runners/python/run_pyxenium.py """, encoding="utf-8", ) - lr_db = benchmark / "data" / "lr.tsv" - lr_db.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") + cci_resource = benchmark / "data" / "cci.tsv" + cci_resource.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") (benchmark / "data" / "input_manifest.json").write_text( - json.dumps({"lr_db_common_tsv": str(lr_db), "smoke_h5ad": str(benchmark / "data" / "smoke.h5ad"), "full_bundle": {}}), + json.dumps({"cci_resource_common_tsv": str(cci_resource), "smoke_h5ad": str(benchmark / "data" / "smoke.h5ad"), "full_bundle": {}}), encoding="utf-8", ) @@ -731,7 +837,7 @@ def test_prepare_a100_bundle_reports_blocked_without_full_bundle(monkeypatch, tm def test_prepare_a100_bundle_can_plan_remote_prepare_when_full_bundle_is_missing(monkeypatch, tmp_path): monkeypatch.chdir(tmp_path) - benchmark = tmp_path / "benchmarking" / "lr_2026_atera" + benchmark = tmp_path / "benchmarking" / "cci_2026_atera" (benchmark / "configs").mkdir(parents=True) (benchmark / "envs").mkdir() (benchmark / "scripts").mkdir() @@ -747,17 +853,17 @@ def test_prepare_a100_bundle_can_plan_remote_prepare_when_full_bundle_is_missing - slug: pyxenium display_name: pyXenium language: python - env_name: pyx-lr-pyxenium + env_name: pyx-cci-pyxenium runner: runners/python/run_pyxenium.py """, encoding="utf-8", ) - lr_db = benchmark / "data" / "lr.tsv" + cci_resource = benchmark / "data" / "cci.tsv" smoke_h5ad = benchmark / "data" / "smoke.h5ad" - lr_db.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") + cci_resource.write_text("ligand\treceptor\nCXCL12\tCXCR4\n", encoding="utf-8") smoke_h5ad.touch() (benchmark / "data" / "input_manifest.json").write_text( - json.dumps({"lr_db_common_tsv": str(lr_db), "smoke_h5ad": str(smoke_h5ad), "full_bundle": {}}), + json.dumps({"cci_resource_common_tsv": str(cci_resource), "smoke_h5ad": str(smoke_h5ad), "full_bundle": {}}), encoding="utf-8", ) @@ -778,7 +884,7 @@ def test_prepare_a100_bundle_can_plan_remote_prepare_when_full_bundle_is_missing def test_execute_a100_stage_plan_tar_scp_dry_run(tmp_path, monkeypatch): repo = tmp_path / "repo" - benchmark = repo / "benchmarking" / "lr_2026_atera" + benchmark = repo / "benchmarking" / "cci_2026_atera" (benchmark / "configs").mkdir(parents=True) (benchmark / "envs").mkdir() (benchmark / "scripts").mkdir() @@ -835,7 +941,7 @@ def test_run_a100_plan_remote_dry_run_exposes_wrapper_command(tmp_path): def test_collect_a100_results_scp_dry_run(tmp_path, monkeypatch): - benchmark = tmp_path / "benchmarking" / "lr_2026_atera" + benchmark = tmp_path / "benchmarking" / "cci_2026_atera" (tmp_path / "pyproject.toml").write_text("[project]\nname='toy'\n", encoding="utf-8") (benchmark / "configs").mkdir(parents=True) (benchmark / "results").mkdir() @@ -859,7 +965,7 @@ def test_collect_a100_results_scp_dry_run(tmp_path, monkeypatch): def test_collect_a100_results_records_since_last_flag(tmp_path, monkeypatch): - benchmark = tmp_path / "benchmarking" / "lr_2026_atera" + benchmark = tmp_path / "benchmarking" / "cci_2026_atera" (tmp_path / "pyproject.toml").write_text("[project]\nname='toy'\n", encoding="utf-8") (benchmark / "configs").mkdir(parents=True) (benchmark / "results").mkdir() @@ -881,7 +987,7 @@ def test_collect_a100_results_records_since_last_flag(tmp_path, monkeypatch): def test_submit_monitor_and_finalize_a100_matrix_dry_run(tmp_path, monkeypatch): repo = tmp_path / "repo" - benchmark = repo / "benchmarking" / "lr_2026_atera" + benchmark = repo / "benchmarking" / "cci_2026_atera" (benchmark / "configs").mkdir(parents=True) (benchmark / "runs" / "a100_collected" / "full_common" / "laris").mkdir(parents=True) (benchmark / "results").mkdir(parents=True) @@ -892,7 +998,7 @@ def test_submit_monitor_and_finalize_a100_matrix_dry_run(tmp_path, monkeypatch): - slug: laris display_name: LARIS language: python - env_name: pyx-lr-laris + env_name: pyx-cci-laris runner: scripts/run_method.py """, encoding="utf-8", @@ -904,7 +1010,7 @@ def test_submit_monitor_and_finalize_a100_matrix_dry_run(tmp_path, monkeypatch): methods=["laris"], phase="full", database_mode="common-db", - max_lr_pairs=3, + max_cci_pairs=3, ) matrix_json = benchmark / "logs" / "matrix.json" matrix_json.parent.mkdir(parents=True, exist_ok=True) @@ -930,7 +1036,7 @@ def test_submit_monitor_and_finalize_a100_matrix_dry_run(tmp_path, monkeypatch): "receptor": "CXCR4", "sender_celltype": "A", "receiver_celltype": "B", - "LR_score": 1.0, + "CCI_score": 1.0, } ] ), @@ -997,7 +1103,7 @@ def test_render_report_includes_run_status_and_canonical_rank_matrix(): "receptor": "CXCR4", "sender_celltype": "CAFs, DCIS Associated", "receiver_celltype": "T Lymphocytes", - "LR_score": 1.0, + "CCI_score": 1.0, } ] ), @@ -1018,7 +1124,7 @@ def test_render_report_includes_run_status_and_canonical_rank_matrix(): biology = score_biological_performance(canonical_summary=canonical_summary, pathway_summary=pathway_summary) run_status = pd.DataFrame([{"method": "pyxenium", "phase": "full", "database_mode": "common-db", "status": "success", "n_rows": 1}]) - report = render_atera_lr_benchmark_report( + report = render_atera_cci_benchmark_report( combined_results=combined, canonical_summary=canonical_summary, pathway_summary=pathway_summary, diff --git a/tests/test_cli.py b/tests/test_cli.py index cc72a14..9b01734 100644 --- a/tests/test_cli.py +++ b/tests/test_cli.py @@ -309,10 +309,10 @@ def fake_run_atera_wta_breast_topology(**kwargs): "cluster_cell_counts": [], "metrics_summary": {"median_transcripts_per_cell": 2116}, "experiment_metadata": {"panel_num_targets_predesigned": 18028}, - "lr_smoke_panel": [], + "cci_smoke_panel": [], "pathway_smoke_panel": [], - "lr_pair_summaries": [], - "lr_acceptance": [], + "cci_pair_summaries": [], + "cci_acceptance": [], "pathway_primary_best": [], "pathway_activity_best": [], "pathway_acceptance": [], diff --git a/tests/test_gmi_pdc_plan.py b/tests/test_gmi_pdc_plan.py index 25e1f31..75016c4 100644 --- a/tests/test_gmi_pdc_plan.py +++ b/tests/test_gmi_pdc_plan.py @@ -24,9 +24,9 @@ def test_pdc_path_policy_requires_separate_klemming_scratch_root(): pdc_xenium_root=DEFAULT_GMI_PDC_XENIUM_ROOT, pdc_root="/cfs/klemming/home/h/hutaobo/pyxenium_gmi", ) - lr_root = validate_pdc_gmi_path_policy( + cci_root = validate_pdc_gmi_path_policy( pdc_xenium_root=DEFAULT_GMI_PDC_XENIUM_ROOT, - pdc_root="/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04/runs/gmi", + pdc_root="/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04/runs/gmi", ) inside_data = validate_pdc_gmi_path_policy( pdc_xenium_root=DEFAULT_GMI_PDC_XENIUM_ROOT, @@ -36,8 +36,8 @@ def test_pdc_path_policy_requires_separate_klemming_scratch_root(): assert valid["valid"] is True assert home["valid"] is False assert any("scratch" in issue or "home" in issue for issue in home["issues"]) - assert lr_root["valid"] is False - assert any("separate from the LR benchmark root" in issue for issue in lr_root["issues"]) + assert cci_root["valid"] is False + assert any("separate from the CCI benchmark root" in issue for issue in cci_root["issues"]) assert inside_data["valid"] is False assert any("source cache" in issue for issue in inside_data["issues"]) @@ -78,7 +78,7 @@ def test_build_gmi_pdc_plan_uses_slurm_chain_and_expected_stages(): assert "--dependency=afterok:${full_contour_top500_spatial100_JOB_ID}" in " ".join(stability["sbatch"]) assert all("--account=naiss-test" in stage["sbatch"] for stage in payload["stages"]) assert all("--contour-geojson" in stage["command"] for stage in payload["stages"]) - assert all("/pyxenium_lr_benchmark_2026-04/" not in stage["output_dir"] for stage in payload["stages"]) + assert all("/pyxenium_cci_benchmark_2026-04/" not in stage["output_dir"] for stage in payload["stages"]) assert all("nohup" not in stage["sbatch_command"] for stage in payload["stages"]) assert all("sbatch" == stage["sbatch"][0] for stage in payload["stages"]) diff --git a/tests/test_pdc_benchmark_scripts.py b/tests/test_pdc_benchmark_scripts.py index a495997..e5523fa 100644 --- a/tests/test_pdc_benchmark_scripts.py +++ b/tests/test_pdc_benchmark_scripts.py @@ -6,7 +6,7 @@ REPO_ROOT = Path(__file__).resolve().parents[1] -PDC_SCRIPT_DIR = REPO_ROOT / "benchmarking" / "lr_2026_atera" / "scripts" / "pdc" +PDC_SCRIPT_DIR = REPO_ROOT / "benchmarking" / "cci_2026_atera" / "scripts" / "pdc" def _load_script(name: str): @@ -31,7 +31,7 @@ def test_pdc_stage_plan_uses_scratch_outputs_and_minimal_raw_inputs(tmp_path): plan = stage.build_stage_plan( repo_root=tmp_path, local_xenium_root=source, - remote_root="/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04", + remote_root="/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04", host="pdc", include_smoke=True, include_spatialdata_zarr=True, @@ -51,7 +51,7 @@ def test_pdc_submit_matrix_builds_slurm_dependencies_and_path_policy(): jobs = submit.build_jobs( ["pyxenium", "cellchat"], - "/cfs/klemming/scratch/h/hutaobo/pyxenium_lr_benchmark_2026-04", + "/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04", "naiss2026-4-680", {"prepare", "env", "smoke", "pilot"}, include_full=False, diff --git a/tests/test_topology_analysis.py b/tests/test_topology_analysis.py index dc4c69b..01b50aa 100644 --- a/tests/test_topology_analysis.py +++ b/tests/test_topology_analysis.py @@ -5,10 +5,10 @@ from pyXenium import ( compute_pathway_activity_matrix, - ligand_receptor_topology_analysis, + cci_topology_analysis, pathway_topology_analysis, ) -from pyXenium.ligand_receptor import ligand_receptor_topology_analysis as ligand_receptor_topology_analysis_direct +from pyXenium.cci import cci_topology_analysis as cci_topology_analysis_direct from pyXenium.pathway import ( compute_pathway_activity_matrix as compute_pathway_activity_matrix_direct, pathway_topology_analysis as pathway_topology_analysis_direct, @@ -61,18 +61,18 @@ def _toy_structure_map() -> pd.DataFrame: def test_public_topology_exports_are_importable(): - assert callable(ligand_receptor_topology_analysis) + assert callable(cci_topology_analysis) assert callable(pathway_topology_analysis) assert callable(compute_pathway_activity_matrix) - assert callable(ligand_receptor_topology_analysis_direct) + assert callable(cci_topology_analysis_direct) assert callable(pathway_topology_analysis_direct) assert callable(compute_pathway_activity_matrix_direct) def test_analysis_topology_compatibility_imports_warn_and_resolve(): with pytest.warns(DeprecationWarning): - from pyXenium.analysis.ligand_receptor_topology import ( - ligand_receptor_topology_analysis as legacy_lr_topology_analysis, + from pyXenium.analysis.cci_topology import ( + cci_topology_analysis as analysis_cci_topology_analysis, ) with pytest.warns(DeprecationWarning): @@ -81,22 +81,22 @@ def test_analysis_topology_compatibility_imports_warn_and_resolve(): pathway_topology_analysis as legacy_pathway_topology_analysis, ) - assert legacy_lr_topology_analysis is ligand_receptor_topology_analysis_direct + assert analysis_cci_topology_analysis is cci_topology_analysis_direct assert legacy_pathway_topology_analysis is pathway_topology_analysis_direct assert legacy_compute_pathway_activity_matrix is compute_pathway_activity_matrix_direct -def test_ligand_receptor_precomputed_anchors_match_supplied_topology(): +def test_cci_precomputed_anchors_match_supplied_topology(): reference = _toy_reference() expression = _toy_expression(reference) t_and_c = _toy_t_and_c() structure_map = _toy_structure_map() - lr_pairs = pd.DataFrame([{"ligand": "L1", "receptor": "R1", "evidence_weight": 1.0}]) + interaction_pairs = pd.DataFrame([{"ligand": "L1", "receptor": "R1", "evidence_weight": 1.0}]) - result = ligand_receptor_topology_analysis( + result = cci_topology_analysis( reference_df=reference, expression_df=expression, - lr_pairs=lr_pairs, + interaction_pairs=interaction_pairs, t_and_c_df=t_and_c, structure_map_df=structure_map, export_figures=False, @@ -108,17 +108,17 @@ def test_ligand_receptor_precomputed_anchors_match_supplied_topology(): assert set(result["scores"]["anchor_source_receptor"]) == {"precomputed"} -def test_ligand_receptor_hybrid_marks_fallback_sources_and_zeroes_sparse_contact(): +def test_cci_hybrid_marks_fallback_sources_and_zeroes_sparse_contact(): reference = _toy_reference() expression = _toy_expression(reference) t_and_c = _toy_t_and_c().drop(index=["R2"]) structure_map = _toy_structure_map() - lr_pairs = pd.DataFrame([{"ligand": "L2", "receptor": "R2", "evidence_weight": 1.0}]) + interaction_pairs = pd.DataFrame([{"ligand": "L2", "receptor": "R2", "evidence_weight": 1.0}]) - result = ligand_receptor_topology_analysis( + result = cci_topology_analysis( reference_df=reference, expression_df=expression, - lr_pairs=lr_pairs, + interaction_pairs=interaction_pairs, t_and_c_df=t_and_c, structure_map_df=structure_map, anchor_mode="hybrid", diff --git a/tests/test_validation_module.py b/tests/test_validation_module.py index 55e9448..cf0f0d0 100644 --- a/tests/test_validation_module.py +++ b/tests/test_validation_module.py @@ -108,7 +108,7 @@ def test_renal_immune_resistance_helpers_render_expected_sections(): assert not build_panel_gap_table().empty -def test_atera_breast_topology_report_mentions_lr_and_pathway_sections(): +def test_atera_breast_topology_report_mentions_cci_and_pathway_sections(): payload = { "sample_id": "atera_test", "dataset_root": "/tmp/atera", @@ -121,8 +121,8 @@ def test_atera_breast_topology_report_mentions_lr_and_pathway_sections(): "experiment_metadata": {"panel_num_targets_predesigned": 18028}, "metrics_summary": {"median_transcripts_per_cell": 2116}, "runtime_seconds": 1.23, - "lr_pair_summaries": [{"ligand": "CSF1", "receptor": "CSF1R", "best_sender_celltype": "CAFs", "best_receiver_celltype": "Macrophages", "best_score": 0.42}], - "lr_acceptance": [{"check": "CSF1-CSF1R top sender should not be Mast Cells", "pass": True}], + "cci_pair_summaries": [{"ligand": "CSF1", "receptor": "CSF1R", "best_sender_celltype": "CAFs", "best_receiver_celltype": "Macrophages", "best_score": 0.42}], + "cci_acceptance": [{"check": "CSF1-CSF1R top sender should not be Mast Cells", "pass": True}], "pathway_primary_best": [{"pathway": "MacrophageProgram", "best_celltype": "Macrophages", "best_distance": 0.02}], "pathway_acceptance": [{"pathway": "MacrophageProgram", "expected_best_celltypes": ["Macrophages"], "observed_best_celltype": "Macrophages", "pass": True}], "files": {"summary_json": "/tmp/atera/summary.json"}, @@ -131,5 +131,5 @@ def test_atera_breast_topology_report_mentions_lr_and_pathway_sections(): report = render_atera_wta_breast_topology_report(payload) assert "# Atera WTA Breast Topology Reproducibility Bundle" in report - assert "## LR Smoke Panel" in report + assert "## CCI Smoke Panel" in report assert "## Pathway Primary Results" in report From 4cf4868cbeeeeac76d3a0e9bf2c7adaec25a3559 Mon Sep 17 00:00:00 2001 From: hutaobo Date: Wed, 29 Apr 2026 17:39:59 +0200 Subject: [PATCH 2/2] chore: collect 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-5,7 +5,7 @@

pyXenium

- Xenium I/O, multimodal analysis, topology workflows, contour-native spatial profiling, GMI inference, mechanostress analysis, and AI-driven spatial pathology handoff. + Xenium I/O, multimodal analysis, topology workflows, contour-native spatial profiling, GMI inference, mechanostress analysis, and optional external workflow bridges.

@@ -28,7 +28,7 @@ Releases

-pyXenium is a Python toolkit for **10x Genomics Xenium** with eight feature areas: +pyXenium is a Python toolkit for **10x Genomics Xenium** with nine feature areas: - `pyXenium.io`: Xenium artifact loading, partial export recovery, SData I/O, and SpatialData-compatible export. - `pyXenium.multimodal`: canonical RNA + protein loading, joint analysis, immune-resistance scoring, and packaged workflows. @@ -38,11 +38,12 @@ pyXenium is a Python toolkit for **10x Genomics Xenium** with eight feature area - `pyXenium.gmi`: contour-level GMI modeling for sparse main-effect and interaction discovery in spatial transcriptomics. - `pyXenium.mechanostress`: morphology-derived mechanical stress states, including fibroblast axis strength, tumor-stroma growth patterning, and cell polarity. - AI-Driven Spatial Pathologist via `spatho`: an optional external workflow layer for AI-driven spatial pathology, built on the Xenium data foundation provided by pyXenium's `XeniumSData` structure. +- `pyXenium.perturb`: SpatialPerturb Bridge for optional Perturb-seq reference projection onto Xenium tissue through the external `SpatialPerturb` package. Legacy compatibility entry points under `pyXenium.analysis`, `pyXenium.validation`, and `pyXenium.io.load_xenium_gene_protein(...)` remain importable, but new code should target the -canonical pyXenium namespaces above. The `spatho` workflow is installed and run separately; pyXenium -does not vendor it or add it as a runtime dependency. +canonical pyXenium namespaces above. The `spatho` and `SpatialPerturb` workflows are installed +and run separately; pyXenium does not vendor them or add them as core runtime dependencies. ## Release & Build @@ -73,6 +74,12 @@ For documentation work: pip install -e ".[docs]" ``` +For the optional SpatialPerturb Bridge runtime on Python 3.9+: + +```bash +pip install -e ".[perturb]" +``` + ## Quick examples ### Xenium I/O @@ -166,11 +173,39 @@ spatho doctor --config workflow.json spatho run --config workflow.json ``` -In pyXenium, this is documented as the eighth feature area rather than a new package namespace. +In pyXenium, this is documented as an optional external workflow bridge rather than a new +`pyXenium.spatho` namespace. The handoff is possible because `XeniumSData` keeps the cell table, transcript points, cell/nucleus boundaries, H&E image metadata, and SpatialData-compatible organization together for downstream tools. +### SpatialPerturb Bridge via SpatialPerturb + +[`SpatialPerturb`](https://github.com/hutaobo/SpatialPerturb) is an external workflow package +for combining spatial transcriptomics with Perturb-seq references. pyXenium exposes a lightweight +`pyXenium.perturb` bridge that writes a handoff JSON and stable external CLI commands without +vendoring the SpatialPerturb algorithms. + +```python +from pyXenium.perturb import SpatialPerturbBridgeConfig, write_spatialperturb_handoff + +spec = write_spatialperturb_handoff( + SpatialPerturbBridgeConfig( + xenium_path="/path/to/Xenium_outs", + output_dir="spatialperturb_reports/breast_case_01", + cell_group_path="/path/to/cell_groups.csv", + roi_geojson_path="/path/to/xenium_explorer_annotations.geojson", + sample_name="breast_case_01", + ), + "spatialperturb_bridge.json", +) +print(spec["command_text"]["run_reference_benchmark"]) +``` + +SpatialPerturb Bridge scores mean Perturb-seq-derived program similarity projected onto Xenium +tissue. They do not mean the tissue cell contains the corresponding knockout, guide, or drug +perturbation. + ## Documentation structure The docs mirror the package surfaces, high-level workflows, and external handoffs: @@ -180,6 +215,7 @@ The docs mirror the package surfaces, high-level workflows, and external handoff - Workflows - API Reference - AI-Driven Spatial Pathologist via `spatho` +- SpatialPerturb Bridge via `SpatialPerturb` - Changelog Start here: [pyxenium.readthedocs.io](https://pyxenium.readthedocs.io/en/latest/) diff --git a/benchmarking/bmnet_pdc/README.md b/benchmarking/bmnet_pdc/README.md new file mode 100644 index 0000000..35d431c --- /dev/null +++ b/benchmarking/bmnet_pdc/README.md @@ -0,0 +1,85 @@ +# BM-Net/H&E morphology increment pilot on PDC + +This scaffold runs a breast H&E morphology increment pilot for the aligned +Xenium RNA + H&E contour workflow. It is intentionally separate from the +published tutorial path so existing `run_contour_boundary_ecology_pilot` +behavior stays unchanged. + +Default dataset: + +```text +/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs +``` + +Default BM-Net pilot root: + +```text +/cfs/klemming/scratch/h/hutaobo/pyxenium_bmnet_morphology_2026-04 +``` + +## Backends + +- `deterministic-smoke`: dependency-free BM-Net-like H&E proxy for validating + contour cropping, schema, artifacts, Slurm, and downstream increment tests. + This is not biological evidence. +- `bmnet-local`: loads a local checkpoint through a MobileNetV3-small BM-Net-like + head. Use this only when a compatible BM-Net checkpoint is available. +- `bmnet-like-trainable`: MobileNetV3-small + classifier head for local + training/fine-tuning experiments. +- `hf-pathology-backbone`: uses a Hugging Face pathology backbone such as + `1aurent/vit_small_patch8_224.lunit_dino` or `wisdomik/QuiltNet-B-32` as a + surrogate feature extractor and writes `pathology__...` features rather than + BM-Net probabilities. + +## PDC workflow + +From the staged repo on Dardel: + +```bash +export PDC_ROOT=/cfs/klemming/scratch/h/hutaobo/pyxenium_bmnet_morphology_2026-04 +export PDC_XENIUM_ROOT=/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs + +bash benchmarking/bmnet_pdc/scripts/bootstrap_pdc_env.sh +bash benchmarking/bmnet_pdc/scripts/submit_pdc_bmnet_pilot.sh --backend deterministic-smoke --include-full +``` + +For a real BM-Net checkpoint: + +```bash +bash benchmarking/bmnet_pdc/scripts/submit_pdc_bmnet_pilot.sh \ + --backend bmnet-local \ + --checkpoint /cfs/klemming/scratch/h/hutaobo/models/bmnet/bmnet.pt \ + --include-full +``` + +For the Hugging Face surrogate backbone discovered during setup: + +```bash +bash benchmarking/bmnet_pdc/scripts/submit_pdc_bmnet_pilot.sh \ + --backend hf-pathology-backbone \ + --hf-model 1aurent/vit_small_patch8_224.lunit_dino \ + --smoke-max-contours 20 +``` + +The smoke job limits the run to 50 contours by default. The full job is +submitted with an `afterok` dependency when `--include-full` is used. + +## Outputs + +Each run directory writes: + +- `contour_features_with_bmnet.csv` +- `bmnet_patch_predictions.csv` +- `program_scores.csv` +- `xenium_native_morphology.csv` +- `he_morphology_features.csv` +- `feature_redundancy.csv` +- `incremental_prediction.csv` +- `partial_associations.csv` +- `matched_review_table.csv` +- `morphology_increment_summary.json` +- `bmnet_pdc_run_summary.json` + +`morphology_increment_summary.json` includes `model_metadata` so downstream +reports can distinguish trained BM-Net, Hugging Face surrogate, and smoke-only +outputs. diff --git a/benchmarking/bmnet_pdc/envs/pyx-bmnet-pdc.yml b/benchmarking/bmnet_pdc/envs/pyx-bmnet-pdc.yml new file mode 100644 index 0000000..d4becfb --- /dev/null +++ b/benchmarking/bmnet_pdc/envs/pyx-bmnet-pdc.yml @@ -0,0 +1,34 @@ +name: pyx-bmnet +channels: + - conda-forge +dependencies: + - python=3.11 + - pip + - git + - numpy + - pandas + - scipy + - scikit-learn + - seaborn + - anndata + - scanpy + - pyarrow + - h5py + - click + - matplotlib + - shapely + - statsmodels + - tifffile + - imagecodecs + - zarr + - fsspec + - requests + - pyyaml + - aiohttp + - pillow + - pip: + - -e ../../.. + - torch + - timm>=1.0 + - transformers>=4.40 + - huggingface_hub>=0.24 diff --git a/benchmarking/bmnet_pdc/scripts/bootstrap_pdc_env.sh b/benchmarking/bmnet_pdc/scripts/bootstrap_pdc_env.sh new file mode 100644 index 0000000..f2e3246 --- /dev/null +++ b/benchmarking/bmnet_pdc/scripts/bootstrap_pdc_env.sh @@ -0,0 +1,34 @@ +#!/usr/bin/env bash +set -euo pipefail + +PDC_ROOT="${PDC_ROOT:-/cfs/klemming/scratch/h/hutaobo/pyxenium_bmnet_morphology_2026-04}" +REPO_DIR="${REPO_DIR:-${PDC_ROOT}/repo}" +CONDA_PREFIX="${CONDA_PREFIX:-${PDC_ROOT}/conda/envs/pyx-bmnet}" +CONDA_PKGS_DIR="${CONDA_PKGS_DIR:-${PDC_ROOT}/conda/pkgs}" +LOG_DIR="${PDC_ROOT}/logs" + +mkdir -p "${LOG_DIR}" "${PDC_ROOT}/conda/envs" "${CONDA_PKGS_DIR}" "${PDC_ROOT}/tmp" +exec > >(tee -a "${LOG_DIR}/bootstrap_pdc_env.log") 2>&1 + +echo "[bmnet-pdc] bootstrap started $(date -Is)" +echo "[bmnet-pdc] pdc_root=${PDC_ROOT}" +echo "[bmnet-pdc] repo_dir=${REPO_DIR}" +echo "[bmnet-pdc] conda_prefix=${CONDA_PREFIX}" + +module load PDC/24.11 +module load miniconda3/25.3.1-1-cpeGNU-24.11 + +export CONDA_PKGS_DIRS="${CONDA_PKGS_DIR}" +export TMPDIR="${PDC_ROOT}/tmp" + +cd "${REPO_DIR}" + +if [[ -d "${CONDA_PREFIX}" ]]; then + echo "[bmnet-pdc] updating conda prefix" + conda env update --prefix "${CONDA_PREFIX}" --file benchmarking/bmnet_pdc/envs/pyx-bmnet-pdc.yml --prune +else + echo "[bmnet-pdc] creating conda prefix" + conda env create --prefix "${CONDA_PREFIX}" --file benchmarking/bmnet_pdc/envs/pyx-bmnet-pdc.yml +fi + +echo "[bmnet-pdc] bootstrap completed $(date -Is)" diff --git a/benchmarking/bmnet_pdc/scripts/run_bmnet_morphology_increment.py b/benchmarking/bmnet_pdc/scripts/run_bmnet_morphology_increment.py new file mode 100644 index 0000000..ce28996 --- /dev/null +++ b/benchmarking/bmnet_pdc/scripts/run_bmnet_morphology_increment.py @@ -0,0 +1,79 @@ +#!/usr/bin/env python +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +from pyXenium.multimodal import run_bmnet_morphology_increment_pilot + + +def build_parser() -> argparse.ArgumentParser: + parser = argparse.ArgumentParser(description="Run BM-Net/H&E morphology increment pilot.") + parser.add_argument("--dataset-root", required=True) + parser.add_argument("--output-dir", required=True) + parser.add_argument("--contour-geojson", default=None) + parser.add_argument("--contour-key", default="s1_s5_contours") + parser.add_argument("--contour-id-key", default="polygon_id") + parser.add_argument("--contour-coordinate-space", default="xenium_pixel") + parser.add_argument("--contour-pixel-size-um", type=float, default=None) + parser.add_argument("--he-image-key", default="he") + parser.add_argument("--cells-parquet", default="cells.parquet") + parser.add_argument("--clusters-relpath", default="WTA_Preview_FFPE_Breast_Cancer_cell_groups.csv") + parser.add_argument("--cluster-column-name", default="cluster") + parser.add_argument( + "--backend", + default="deterministic-smoke", + choices=["deterministic-smoke", "bmnet-local", "bmnet-like-trainable", "hf-pathology-backbone"], + ) + parser.add_argument("--checkpoint", default=None) + parser.add_argument("--hf-model", default="1aurent/vit_small_patch8_224.lunit_dino") + parser.add_argument("--timm-architecture", default="mobilenetv3_small_100") + parser.add_argument("--timm-pretrained", action="store_true") + parser.add_argument("--max-contours", type=int, default=None) + parser.add_argument("--inner-rim-um", type=float, default=20.0) + parser.add_argument("--outer-rim-um", type=float, default=30.0) + parser.add_argument("--skip-pathomics", action="store_true") + parser.add_argument("--include-transcripts", action="store_true") + parser.add_argument("--program-library", default="breast_boundary_bmnet_v1") + parser.add_argument("--random-state", type=int, default=0) + parser.add_argument("--min-contours", type=int, default=8) + return parser + + +def main(argv: list[str] | None = None) -> int: + args = build_parser().parse_args(argv) + result = run_bmnet_morphology_increment_pilot( + dataset_root=args.dataset_root, + output_dir=args.output_dir, + contour_geojson=args.contour_geojson, + contour_key=args.contour_key, + contour_id_key=args.contour_id_key, + contour_coordinate_space=args.contour_coordinate_space, + contour_pixel_size_um=args.contour_pixel_size_um, + he_image_key=args.he_image_key, + cells_parquet=args.cells_parquet, + clusters_relpath=args.clusters_relpath, + cluster_column_name=args.cluster_column_name, + backend=args.backend, + checkpoint=args.checkpoint, + hf_model=args.hf_model, + timm_architecture=args.timm_architecture, + timm_pretrained=args.timm_pretrained, + max_contours=args.max_contours, + inner_rim_um=args.inner_rim_um, + outer_rim_um=args.outer_rim_um, + include_pathomics=not args.skip_pathomics, + include_transcripts=args.include_transcripts, + program_library=args.program_library, + random_state=args.random_state, + min_contours=args.min_contours, + ) + summary = result["summary"] + print(json.dumps({"artifact_dir": result["artifact_dir"], "summary": summary}, indent=2, default=str)) + summary_path = Path(summary["artifact_files"]["run_summary"]) + return 0 if summary_path.exists() else 1 + + +if __name__ == "__main__": + raise SystemExit(main()) diff --git a/benchmarking/bmnet_pdc/scripts/run_pdc_bmnet_pilot.sh b/benchmarking/bmnet_pdc/scripts/run_pdc_bmnet_pilot.sh new file mode 100644 index 0000000..5ac29b9 --- /dev/null +++ b/benchmarking/bmnet_pdc/scripts/run_pdc_bmnet_pilot.sh @@ -0,0 +1,88 @@ +#!/usr/bin/env bash +set -euo pipefail + +RUN_ID="${RUN_ID:-bmnet_smoke_$(date +%Y%m%d_%H%M%S)}" +PDC_ROOT="${PDC_ROOT:-/cfs/klemming/scratch/h/hutaobo/pyxenium_bmnet_morphology_2026-04}" +PDC_XENIUM_ROOT="${PDC_XENIUM_ROOT:-/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs}" +REPO_DIR="${REPO_DIR:-${PDC_ROOT}/repo}" +CONDA_PREFIX="${CONDA_PREFIX:-${PDC_ROOT}/conda/envs/pyx-bmnet}" +CONTOUR_GEOJSON="${CONTOUR_GEOJSON:-${PDC_XENIUM_ROOT}/xenium_explorer_annotations.s1_s5.generated.geojson}" +BACKEND="${BACKEND:-deterministic-smoke}" +CHECKPOINT="${CHECKPOINT:-}" +HF_MODEL="${HF_MODEL:-1aurent/vit_small_patch8_224.lunit_dino}" +MAX_CONTOURS="${MAX_CONTOURS:-50}" +PROGRAM_LIBRARY="${PROGRAM_LIBRARY:-breast_boundary_bmnet_v1}" + +while [[ $# -gt 0 ]]; do + case "$1" in + --run-id) RUN_ID="$2"; shift 2 ;; + --pdc-root) PDC_ROOT="$2"; shift 2 ;; + --dataset-root|--pdc-xenium-root) PDC_XENIUM_ROOT="$2"; shift 2 ;; + --repo-dir) REPO_DIR="$2"; shift 2 ;; + --conda-prefix) CONDA_PREFIX="$2"; shift 2 ;; + --contour-geojson) CONTOUR_GEOJSON="$2"; shift 2 ;; + --backend) BACKEND="$2"; shift 2 ;; + --checkpoint) CHECKPOINT="$2"; shift 2 ;; + --hf-model) HF_MODEL="$2"; shift 2 ;; + --max-contours) MAX_CONTOURS="$2"; shift 2 ;; + --program-library) PROGRAM_LIBRARY="$2"; shift 2 ;; + *) echo "[bmnet-pdc] unknown option: $1" >&2; exit 2 ;; + esac +done + +if [[ ! -d "${PDC_XENIUM_ROOT}" ]]; then + echo "[bmnet-pdc] missing dataset root: ${PDC_XENIUM_ROOT}" >&2 + exit 2 +fi +if [[ ! -d "${CONDA_PREFIX}" ]]; then + echo "[bmnet-pdc] missing conda prefix: ${CONDA_PREFIX}" >&2 + echo "[bmnet-pdc] run benchmarking/bmnet_pdc/scripts/bootstrap_pdc_env.sh first." >&2 + exit 2 +fi +if [[ ! -s "${CONTOUR_GEOJSON}" ]]; then + echo "[bmnet-pdc] missing contour GeoJSON: ${CONTOUR_GEOJSON}" >&2 + echo "[bmnet-pdc] run benchmarking/gmi_pdc/scripts/prepare_pdc_inputs.sh if the S1/S5 GeoJSON has not been generated." >&2 + exit 2 +fi + +LOG_DIR="${PDC_ROOT}/logs" +OUT_DIR="${PDC_ROOT}/runs/${RUN_ID}" +mkdir -p "${LOG_DIR}" "${OUT_DIR}" "${PDC_ROOT}/tmp" +exec > >(tee -a "${LOG_DIR}/${RUN_ID}.log") 2>&1 + +echo "[bmnet-pdc] run_id=${RUN_ID} started $(date -Is)" +echo "[bmnet-pdc] dataset=${PDC_XENIUM_ROOT}" +echo "[bmnet-pdc] output=${OUT_DIR}" +echo "[bmnet-pdc] backend=${BACKEND}" +echo "[bmnet-pdc] checkpoint=${CHECKPOINT:-none}" +echo "[bmnet-pdc] hf_model=${HF_MODEL}" +echo "[bmnet-pdc] max_contours=${MAX_CONTOURS:-all}" + +module load PDC/24.11 +module load miniconda3/25.3.1-1-cpeGNU-24.11 + +export TMPDIR="${PDC_ROOT}/tmp" +export PYTHONNOUSERSITE=1 +export PYTHONPATH="${REPO_DIR}/src:${PYTHONPATH:-}" + +cd "${REPO_DIR}" + +ARGS=( + benchmarking/bmnet_pdc/scripts/run_bmnet_morphology_increment.py + --dataset-root "${PDC_XENIUM_ROOT}" + --output-dir "${OUT_DIR}" + --contour-geojson "${CONTOUR_GEOJSON}" + --backend "${BACKEND}" + --hf-model "${HF_MODEL}" + --program-library "${PROGRAM_LIBRARY}" +) +if [[ -n "${CHECKPOINT}" ]]; then + ARGS+=(--checkpoint "${CHECKPOINT}") +fi +if [[ -n "${MAX_CONTOURS}" ]]; then + ARGS+=(--max-contours "${MAX_CONTOURS}") +fi + +conda run --prefix "${CONDA_PREFIX}" python "${ARGS[@]}" + +echo "[bmnet-pdc] run_id=${RUN_ID} completed $(date -Is)" diff --git a/benchmarking/bmnet_pdc/scripts/submit_pdc_bmnet_pilot.sh b/benchmarking/bmnet_pdc/scripts/submit_pdc_bmnet_pilot.sh new file mode 100644 index 0000000..d9070c2 --- /dev/null +++ b/benchmarking/bmnet_pdc/scripts/submit_pdc_bmnet_pilot.sh @@ -0,0 +1,98 @@ +#!/usr/bin/env bash +set -euo pipefail + +PDC_ROOT="${PDC_ROOT:-/cfs/klemming/scratch/h/hutaobo/pyxenium_bmnet_morphology_2026-04}" +PDC_XENIUM_ROOT="${PDC_XENIUM_ROOT:-/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/data/source_cache/breast/WTA_Preview_FFPE_Breast_Cancer_outs}" +REPO_DIR="${REPO_DIR:-${PDC_ROOT}/repo}" +CONDA_PREFIX="${CONDA_PREFIX:-${PDC_ROOT}/conda/envs/pyx-bmnet}" +CONTOUR_GEOJSON="${CONTOUR_GEOJSON:-${PDC_XENIUM_ROOT}/xenium_explorer_annotations.s1_s5.generated.geojson}" +BACKEND="${BACKEND:-deterministic-smoke}" +CHECKPOINT="${CHECKPOINT:-}" +HF_MODEL="${HF_MODEL:-1aurent/vit_small_patch8_224.lunit_dino}" +ACCOUNT="${PDC_PROJECT:-}" +SMOKE_MAX_CONTOURS="${SMOKE_MAX_CONTOURS:-50}" +INCLUDE_FULL=0 +DRY_RUN=0 + +while [[ $# -gt 0 ]]; do + case "$1" in + --pdc-root) PDC_ROOT="$2"; shift 2 ;; + --dataset-root|--pdc-xenium-root) PDC_XENIUM_ROOT="$2"; shift 2 ;; + --repo-dir) REPO_DIR="$2"; shift 2 ;; + --conda-prefix) CONDA_PREFIX="$2"; shift 2 ;; + --contour-geojson) CONTOUR_GEOJSON="$2"; shift 2 ;; + --backend) BACKEND="$2"; shift 2 ;; + --checkpoint) CHECKPOINT="$2"; shift 2 ;; + --hf-model) HF_MODEL="$2"; shift 2 ;; + --account) ACCOUNT="$2"; shift 2 ;; + --smoke-max-contours) SMOKE_MAX_CONTOURS="$2"; shift 2 ;; + --include-full) INCLUDE_FULL=1; shift ;; + --dry-run) DRY_RUN=1; shift ;; + *) echo "[bmnet-pdc] unknown option: $1" >&2; exit 2 ;; + esac +done + +mkdir -p "${PDC_ROOT}/logs" "${PDC_ROOT}/runs" "${PDC_ROOT}/tmp" + +module load PDC/24.11 +module load miniconda3/25.3.1-1-cpeGNU-24.11 + +if [[ -z "${ACCOUNT}" ]]; then + mapfile -t ACCOUNTS < <(projinfo 2>/dev/null | awk '/^[a-zA-Z0-9_-]+[[:space:]]/ {print $1}' | sort -u) + if [[ ${#ACCOUNTS[@]} -eq 1 ]]; then + ACCOUNT="${ACCOUNTS[0]}" + else + echo "[bmnet-pdc] unable to infer a single Slurm account. Set PDC_PROJECT or pass --account." >&2 + printf '[bmnet-pdc] projinfo candidates: %s\n' "${ACCOUNTS[*]:-none}" >&2 + exit 2 + fi +fi + +submit_job() { + local run_id="$1" + local max_contours="$2" + local partition="$3" + local mem="$4" + local time_limit="$5" + local dependency="${6:-}" + local cmd="bash ${REPO_DIR}/benchmarking/bmnet_pdc/scripts/run_pdc_bmnet_pilot.sh --run-id ${run_id} --pdc-root ${PDC_ROOT} --dataset-root ${PDC_XENIUM_ROOT} --repo-dir ${REPO_DIR} --conda-prefix ${CONDA_PREFIX} --contour-geojson ${CONTOUR_GEOJSON} --backend ${BACKEND} --hf-model ${HF_MODEL} --program-library breast_boundary_bmnet_v1" + if [[ -n "${CHECKPOINT}" ]]; then + cmd="${cmd} --checkpoint ${CHECKPOINT}" + fi + if [[ -n "${max_contours}" ]]; then + cmd="${cmd} --max-contours ${max_contours}" + else + cmd="${cmd} --max-contours ''" + fi + local sbatch_cmd=( + sbatch + "--job-name=pyxbmnet_${run_id:0:20}" + "--partition=${partition}" + "--nodes=1" + "--ntasks=1" + "--cpus-per-task=16" + "--mem=${mem}" + "--time=${time_limit}" + "--output=${PDC_ROOT}/logs/${run_id}.%j.log" + "--account=${ACCOUNT}" + ) + if [[ -n "${dependency}" ]]; then + sbatch_cmd+=("--dependency=afterok:${dependency}") + fi + sbatch_cmd+=(--wrap "${cmd}") + if [[ "${DRY_RUN}" -eq 1 ]]; then + printf '%q ' "${sbatch_cmd[@]}" >&2 + printf '\n' >&2 + echo "DRYRUN_${run_id}" + else + local result + result="$("${sbatch_cmd[@]}")" + echo "${result}" >&2 + awk '{print $NF}' <<<"${result}" + fi +} + +SMOKE_ID="$(submit_job "bmnet_smoke_${BACKEND//-/_}" "${SMOKE_MAX_CONTOURS}" "shared" "80GB" "04:00:00")" +if [[ "${INCLUDE_FULL}" -eq 1 ]]; then + submit_job "bmnet_full_${BACKEND//-/_}" "" "main" "220GB" "24:00:00" "${SMOKE_ID}" >/dev/null +fi diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/README.md b/benchmarking/cci_2026_atera/a100_validation_collected/README.md new file mode 100644 index 0000000..89c9121 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/README.md @@ -0,0 +1,16 @@ +# TopoLink-CCI validation run on A100 + +Purpose: computational false-positive controls for top TopoLink-CCI axes. + +This folder intentionally reuses existing benchmark artifacts via symlinks instead of duplicating the full Xenium export. + +Layout: +- scripts/: validation framework and launch script. +- data_links/full_sparse_bundle -> /data/taobo.hu/topolink_cci_benchmark_2026-04/data/full +- data_links/full_common_results -> /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common +- data_links/input_manifest.json -> /data/taobo.hu/topolink_cci_benchmark_2026-04/data/input_manifest.json +- outputs/: evidence tables, false-positive controls, scoreboard, figures, run_summary.json. +- logs/: stdout/stderr plus /usr/bin/time resource report. +- tmp/: job-local temporary files. + +No writes are made to /mnt. The original local Windows Xenium outs are not re-uploaded because the A100 already has the derived full sparse bundle and benchmark outputs needed for this validation. diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_logs/run.stderr.log b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_logs/run.stderr.log new file mode 100644 index 0000000..635dd8a --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_logs/run.stderr.log @@ -0,0 +1,23 @@ + Command being timed: "/home/taobo.hu/miniconda3/bin/conda run -n pyx-cci-pyxenium python /data/taobo.hu/topolink_cci_validation_20260428/scripts/topolink_cci_validation_framework.py --root /data/taobo.hu/topolink_cci_benchmark_2026-04 --output-dir /data/taobo.hu/topolink_cci_validation_20260428/outputs --n-matched-controls 250 --seed 20260428" + User time (seconds): 66.42 + System time (seconds): 29.87 + Percent of CPU this job got: 175% + Elapsed (wall clock) time (h:mm:ss or m:ss): 0:54.82 + Average shared text size (kbytes): 0 + Average unshared data size (kbytes): 0 + Average stack size (kbytes): 0 + Average total size (kbytes): 0 + Maximum resident set size (kbytes): 8917204 + Average resident set size (kbytes): 0 + Major (requiring I/O) page faults: 441 + Minor (reclaiming a frame) page faults: 836764 + Voluntary context switches: 10346 + Involuntary context switches: 9193 + Swaps: 0 + File system inputs: 10927824 + File system outputs: 648 + Socket messages sent: 0 + Socket messages received: 0 + Signals delivered: 0 + Page size (bytes): 4096 + Exit status: 0 diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_logs/run.stdout.log b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_logs/run.stdout.log new file mode 100644 index 0000000..e69de29 diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/figures/topolink_cci_validation_figure.pdf b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/figures/topolink_cci_validation_figure.pdf new file mode 100644 index 0000000000000000000000000000000000000000..d51c97238ce46c6e5caebc8487c563207f803d4a GIT binary patch literal 29716 zcmd442UJu`(>6*F$skdXG-S!l3=A2`86;ME%Szy(E!ILl{XWsO8| zm@v%C?kthCG)&0wytgAvNYU2c*4@h)CZucY?C1wWfCuzpva&>uo(|B1;=jG1;^pZN zL!uuLGCgf~*3sS{CU)>sImlntz~9#25hikQLD$yb-_h3-CJOx|5;AbHb#V1`hM|7m z_4TqhaP)^+fM%6c04a_^{xBhR4?u##&s_0mt`4*MjU4!&9f0VDsP}aQ)E$s7r0?kG z72spTDo8tp`z1&O`HQ z&uQ^vmnKZMs<6jNoP(~I!2$%Q+1}Nv57U~ihfnBH9dF?be73xK?&KMcz7+S{d01la z4YMVjgTxn-BxDD3RXe`DSrB-8#<}}--77ZSop9N6TK8GDKlg@M4X+4NZF{7cUEB7v z{FXN5EBA%1@62ZP`h~!Y3grB&Epa4FzVEKr%-q-#=M{{nzCBUow|+s~wtF+= z=F=A|>&Oc)f~eCnUK)AV?Pz9bg{?dz8oOU;CdzXUXK-D>@ssn8+&qgqsXXW9S$*Zjjp{QWyV;|ttvm&HxX$paRIgEd&75r> zdg}RL$cLaKL9q;5k>Ix0ooXgl+K(5-zsR0Q%n&ll#CxTsU(`&SLD|A-4u43QKJH87 znWDoY_c2)3H1X&nt;RDR&ven%p2^D!qs8xoGGh@@ZiIISGt{4t^(l>9QO}FdWR8~! 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"strong", + "support_count": 6 + }, + { + "axis_id": "DLL4-NOTCH3|Endothelial Cells->Pericytes", + "evidence_class": "strong", + "support_count": 5 + }, + { + "axis_id": "CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes", + "evidence_class": "strong", + "support_count": 5 + }, + { + "axis_id": "JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells", + "evidence_class": "moderate", + "support_count": 4 + } + ], + "outputs": { + "evidence": "/data/taobo.hu/topolink_cci_validation_20260428/outputs/tables/topolink_cci_validation_evidence.tsv", + "controls": "/data/taobo.hu/topolink_cci_validation_20260428/outputs/tables/topolink_cci_false_positive_controls.tsv", + "scoreboard": "/data/taobo.hu/topolink_cci_validation_20260428/outputs/topolink_cci_validation_scoreboard.md", + "figure": "/data/taobo.hu/topolink_cci_validation_20260428/outputs/figures/topolink_cci_validation_figure.png" + } +} \ No newline at end of file diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_component_ablation.tsv b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_component_ablation.tsv new file mode 100644 index 0000000..ede4740 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_component_ablation.tsv @@ -0,0 +1,50 @@ +axis_id removed_component score_without_component rank_without_component +VWF-SELP|Endothelial Cells->Endothelial Cells sender_anchor 0.7936685312319989 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated sender_anchor 0.7223245865106046 8 +MMRN2-CD93|Endothelial Cells->Endothelial Cells sender_anchor 0.7085348212720359 13 +DLL4-NOTCH3|Endothelial Cells->Pericytes sender_anchor 0.6745564828093611 25 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes sender_anchor 0.6525538738821847 36 +CD48-CD2|T Lymphocytes->T Lymphocytes sender_anchor 0.6964889406614021 16 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells sender_anchor 0.650110468858211 40 +VWF-SELP|Endothelial Cells->Endothelial Cells receiver_anchor 0.805686300976693 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated receiver_anchor 0.7689017668792069 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells receiver_anchor 0.7246305722691555 9 +DLL4-NOTCH3|Endothelial Cells->Pericytes receiver_anchor 0.6804202200885041 21 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes receiver_anchor 0.6417024502434168 49 +CD48-CD2|T Lymphocytes->T Lymphocytes receiver_anchor 0.6967533196814983 16 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells receiver_anchor 0.6692416628881765 30 +VWF-SELP|Endothelial Cells->Endothelial Cells structure_bridge 0.7854081482043567 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated structure_bridge 0.7708926279250373 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells structure_bridge 0.7055697377300002 12 +DLL4-NOTCH3|Endothelial Cells->Pericytes structure_bridge 0.6698572931376457 27 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes structure_bridge 0.7130771089942796 8 +CD48-CD2|T Lymphocytes->T Lymphocytes structure_bridge 0.6870622598572897 19 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells structure_bridge 0.6167922060783549 65 +VWF-SELP|Endothelial Cells->Endothelial Cells sender_expr 0.7854081482043567 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated sender_expr 0.7148067405584678 8 +MMRN2-CD93|Endothelial Cells->Endothelial Cells sender_expr 0.7055697377300002 9 +DLL4-NOTCH3|Endothelial Cells->Pericytes sender_expr 0.6628108709697559 33 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes sender_expr 0.6338817361079696 51 +CD48-CD2|T Lymphocytes->T Lymphocytes sender_expr 0.6870622598572897 20 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells sender_expr 0.6167922060783549 75 +VWF-SELP|Endothelial Cells->Endothelial Cells receiver_expr 0.7854081482043567 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated receiver_expr 0.7148067405584678 6 +MMRN2-CD93|Endothelial Cells->Endothelial Cells receiver_expr 0.7055697377300002 8 +DLL4-NOTCH3|Endothelial Cells->Pericytes receiver_expr 0.6787277660885117 24 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes receiver_expr 0.6338817361079696 52 +CD48-CD2|T Lymphocytes->T Lymphocytes receiver_expr 0.6870622598572897 19 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells receiver_expr 0.6167922060783549 79 +VWF-SELP|Endothelial Cells->Endothelial Cells local_contact 0.9646853087387212 16 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated local_contact 0.8530387672375239 614 +MMRN2-CD93|Endothelial Cells->Endothelial Cells local_contact 0.9696210584915509 11 +DLL4-NOTCH3|Endothelial Cells->Pericytes local_contact 0.9248792871416435 76 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes local_contact 0.8529786310985624 615 +CD48-CD2|T Lymphocytes->T Lymphocytes local_contact 0.9727447950557435 7 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells local_contact 0.8743949187647442 329 +VWF-SELP|Endothelial Cells->Endothelial Cells prior_confidence 0.7854081482043567 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated prior_confidence 0.7148067405584678 5 +MMRN2-CD93|Endothelial Cells->Endothelial Cells prior_confidence 0.7055697377300002 6 +DLL4-NOTCH3|Endothelial Cells->Pericytes prior_confidence 0.6628108709697559 20 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes prior_confidence 0.6338817361079696 29 +CD48-CD2|T Lymphocytes->T Lymphocytes prior_confidence 0.6870622598572897 13 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells prior_confidence 0.6167922060783549 41 diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_cross_method_support_detail.tsv b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_cross_method_support_detail.tsv new file mode 100644 index 0000000..ab60aa3 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_cross_method_support_detail.tsv @@ -0,0 +1,50 @@ +axis_id method exact_support same_lr_any_celltype_support same_sender_receiver_support exact_best_rank same_lr_best_rank same_lr_best_score_std artifact_path +VWF-SELP|Endothelial Cells->Endothelial Cells cellchat_conda_full True True True 805.0 805.0 0.974550519118764 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated cellchat_conda_full True True True 22.0 22.0 0.999335274753102 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +MMRN2-CD93|Endothelial Cells->Endothelial Cells cellchat_conda_full True True True 2460.0 2460.0 0.922163838946569 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +DLL4-NOTCH3|Endothelial Cells->Pericytes cellchat_conda_full True True True 4379.0 4379.0 0.86142061281337 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes cellchat_conda_full True True True 638.0 638.0 0.979836667510762 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +CD48-CD2|T Lymphocytes->T Lymphocytes cellchat_conda_full True True True 9528.0 9528.0 0.698436312990631 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cellchat_conda_full True True True 1152.0 389.0 0.987718409723981 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +VWF-SELP|Endothelial Cells->Endothelial Cells cellphonedb True True True 692.0 692.0 0.9994161168645052 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated cellphonedb True True True 2.0 2.0 0.99999915501717 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +MMRN2-CD93|Endothelial Cells->Endothelial Cells cellphonedb True True True 1352.0 1352.0 0.9988584281967392 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +DLL4-NOTCH3|Endothelial Cells->Pericytes cellphonedb True True True 2869.0 2869.0 0.9975765892437064 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes cellphonedb True True True 171.0 171.0 0.9998563529189088 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +CD48-CD2|T Lymphocytes->T Lymphocytes cellphonedb True True True 6381.0 6381.0 0.994609009544926 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cellphonedb True True True 2782.0 1232.0 0.9989598261363328 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +VWF-SELP|Endothelial Cells->Endothelial Cells laris True True True 2845.0 2845.0 0.9978205811017408 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated laris True True True 18.0 18.0 0.9999869725311988 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells laris True True True 5577.0 5577.0 0.99572699023323 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes laris True True True 9878.0 9878.0 0.9924310406265446 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes laris True True True 226.0 226.0 0.9998275776188086 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes laris True True True 15762.0 15762.0 0.987922003777966 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells laris True True True 2153.0 889.0 0.9993195063355648 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells liana True True True 8450.0 1616.0 0.9978299106836924 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated liana True True True 58588.0 3227.0 0.9956651962016048 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +MMRN2-CD93|Endothelial Cells->Endothelial Cells liana True True True 6324.0 3314.0 0.9955482935573206 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +DLL4-NOTCH3|Endothelial Cells->Pericytes liana True True True 81639.0 32868.0 0.955836330923168 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes liana True True True 69984.0 9542.0 0.9871796766768476 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +CD48-CD2|T Lymphocytes->T Lymphocytes liana True True True 23050.0 23050.0 0.9690288615160526 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells liana True True True 1437.0 170.0 0.9997729132542068 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +VWF-SELP|Endothelial Cells->Endothelial Cells spatialdm True True True 1967.0 1896.0 0.9957513401775244 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatialdm True True True 13686.0 13543.0 0.9696383370364308 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatialdm True True True 5602.0 5520.0 0.9876261986489486 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes spatialdm True True True 22202.0 22100.0 0.9504532277483448 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatialdm True True True 16101.0 16018.0 0.964089295843488 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes spatialdm True True True 4354.0 4221.0 0.9905386045114264 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatialdm True True True 9527.0 9527.0 0.9786423570084952 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells squidpy True True True 316.0 316.0 0.999761291300394 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated squidpy True True True 1.0 1.0 1.0 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +MMRN2-CD93|Endothelial Cells->Endothelial Cells squidpy True True True 5514.0 5514.0 0.9958222188541982 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +DLL4-NOTCH3|Endothelial Cells->Pericytes squidpy True True True 5956.0 5956.0 0.9954872688693543 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes squidpy True True True 204.0 204.0 0.9998461655046984 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +CD48-CD2|T Lymphocytes->T Lymphocytes squidpy True True True 26974.0 26974.0 0.9795597150651713 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells squidpy True True True 12740.0 4514.0 0.9965800242497728 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +VWF-SELP|Endothelial Cells->Endothelial Cells stlearn True True True 82562.0 82474.0 0.8367779512785954 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated stlearn True True True 100691.0 100539.0 0.8010255679512984 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells stlearn True True True 88744.0 88651.0 0.8245530704696991 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes stlearn True True True 37015.0 36895.0 0.9269832034056298 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes stlearn True True True 47550.0 47459.0 0.9060760250236995 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes stlearn True True True 161703.0 161549.0 0.6802808734149909 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells stlearn True True True 40130.0 40130.0 0.9205808253229392 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_expression_gene_specificity.tsv b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_expression_gene_specificity.tsv new file mode 100644 index 0000000..e50665c --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_expression_gene_specificity.tsv @@ -0,0 +1,217 @@ +gene detected_in_wta top_celltype_rank cell_type mean_expr detection_fraction +ANGPT2 True 1.0 CAFs, Invasive Associated 0.07923019245188703 0.056235939264297485 +ANGPT2 True 2.0 Pericytes 0.07468777049585755 0.05440830811858177 +ANGPT2 True 3.0 Endothelial Cells 0.06064471243042672 0.0460343211889267 +ANGPT2 True 4.0 Mast Cells 0.02710027100271003 0.027100270614027977 +ANGPT2 True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.0231519090170593 0.01909017004072666 +CCL19 True 1.0 Pericytes 0.16520341288487697 0.053171757608652115 +CCL19 True 2.0 Endothelial Cells 0.0912569573283859 0.04359925910830498 +CCL19 True 3.0 T Lymphocytes 0.08605637316038912 0.05238214135169983 +CCL19 True 4.0 Dendritic Cells 0.07784431137724551 0.04241516813635826 +CCL19 True 5.0 B Cells 0.04856687898089172 0.029458599165081978 +CCL21 True 1.0 Endothelial Cells 0.02481447124304267 0.01982838660478592 +CCL21 True 2.0 Myeloid Cells 0.02214022140221402 0.019680196419358253 +CCL21 True 3.0 Pericytes 0.017559045381476443 0.013725732453167439 +CCL21 True 4.0 Apocrine Cells 0.01488833746898263 0.014888337813317776 +CCL21 True 5.0 Plasma Cells 0.012600229095074456 0.010309278033673763 +CCND1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 45.75142160844842 0.995938241481781 +CCND1 True 2.0 11q13 Invasive Tumor Cells (G1/S) 44.573715248525694 0.9978938698768616 +CCND1 True 3.0 11q13 Invasive Tumor Cells 35.123071397339 0.991645336151123 +CCND1 True 4.0 Basal-like Structured DCIS Cells 14.588698630136987 0.928196370601654 +CCND1 True 5.0 Luminal-like Amorphous DCIS Cells 5.254068160884249 0.8043444752693176 +CD2 True 1.0 T Lymphocytes 0.49837864804190574 0.3382389545440674 +CD2 True 2.0 B Cells 0.09156050955414012 0.07762739062309265 +CD2 True 3.0 Plasma Cells 0.07331042382588775 0.05154639109969139 +CD2 True 4.0 Dendritic Cells 0.060129740518962076 0.049151696264743805 +CD2 True 5.0 Mast Cells 0.04607046070460705 0.04065040498971939 +CD3D True 1.0 T Lymphocytes 0.7599151908206535 0.42105263471603394 +CD3D True 2.0 B Cells 0.1664012738853503 0.10748407989740372 +CD3D True 3.0 Plasma Cells 0.1111111111111111 0.07445590198040009 +CD3D True 4.0 Mast Cells 0.08401084010840108 0.056910570710897446 +CD3D True 5.0 Dendritic Cells 0.08383233532934131 0.057135727256536484 +CD3E True 1.0 T Lymphocytes 1.2775006235969069 0.6097530722618103 +CD3E True 2.0 B Cells 0.2929936305732484 0.20700636506080627 +CD3E True 3.0 Plasma Cells 0.1775486827033219 0.0996563583612442 +CD3E True 4.0 Dendritic Cells 0.12250499001996008 0.08283433318138123 +CD3E True 5.0 Mast Cells 0.056910569105691054 0.046070460230112076 +CD48 True 1.0 T Lymphocytes 0.5604888999750561 0.37989524006843567 +CD48 True 2.0 Dendritic Cells 0.5446606786427146 0.33582833409309387 +CD48 True 3.0 Plasma Cells 0.3104238258877434 0.2279496043920517 +CD48 True 4.0 Mast Cells 0.20596205962059622 0.16802167892456055 +CD48 True 5.0 B Cells 0.18431528662420382 0.14331209659576416 +CD63 False +CD93 True 1.0 Endothelial Cells 0.9689239332096475 0.5012755393981934 +CD93 True 2.0 Pericytes 0.23234821318164955 0.16285395622253418 +CD93 True 3.0 Dendritic Cells 0.2315369261477046 0.16017964482307434 +CD93 True 4.0 Macrophages 0.1983941983941984 0.139860138297081 +CD93 True 5.0 Mast Cells 0.08130081300813008 0.056910570710897446 +CLEC14A True 1.0 Endothelial Cells 1.3179499072356216 0.5895176529884338 +CLEC14A True 2.0 Pericytes 0.31643378261407196 0.20934833586215973 +CLEC14A True 3.0 Myeloid Cells 0.0959409594095941 0.084870845079422 +CLEC14A True 4.0 CAFs, Invasive Associated 0.07173206698325418 0.05373656749725342 +CLEC14A True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.06498781478472786 0.058489032089710236 +COL4A1 True 1.0 Endothelial Cells 2.700139146567718 0.6525974273681641 +COL4A1 True 2.0 CAFs, Invasive Associated 2.4473881529617594 0.6213446855545044 +COL4A1 True 3.0 Pericytes 1.5722764931371336 0.5163843035697937 +COL4A1 True 4.0 CAFs, DCIS Associated 0.6216348907618034 0.3171180784702301 +COL4A1 True 5.0 Myoepithelial Cells 0.40009480919649204 0.2188907265663147 +COL4A2 True 1.0 Endothelial Cells 1.5338589981447124 0.5666744112968445 +COL4A2 True 2.0 CAFs, Invasive Associated 1.4781304673831541 0.5351161956787109 +COL4A2 True 3.0 Pericytes 1.0337578830221343 0.4361320734024048 +COL4A2 True 4.0 CAFs, DCIS Associated 0.5452499795434089 0.33074215054512024 +COL4A2 True 5.0 Myoepithelial Cells 0.5319981038160702 0.31879591941833496 +CXCL12 True 1.0 CAFs, DCIS Associated 3.649660420587513 0.7872514724731445 +CXCL12 True 2.0 CAFs, Invasive Associated 1.556610847288178 0.4851287305355072 +CXCL12 True 3.0 Endothelial Cells 1.3608534322820036 0.47993969917297363 +CXCL12 True 4.0 Macrophages 1.0893550893550894 0.40663039684295654 +CXCL12 True 5.0 Pericytes 1.0134784221590207 0.37875601649284363 +CXCR3 True 1.0 T Lymphocytes 0.034048391119980044 0.03280119597911835 +CXCR3 True 2.0 Plasma Cells 0.014891179839633447 0.014891180209815502 +CXCR3 True 3.0 Dendritic Cells 0.011477045908183632 0.010479042306542397 +CXCR3 True 4.0 Myeloid Cells 0.008610086100861008 0.008610086515545845 +CXCR3 True 5.0 Mast Cells 0.008130081300813009 0.008130080997943878 +CXCR4 True 1.0 T Lymphocytes 0.9085806934397606 0.4825392961502075 +CXCR4 True 2.0 Dendritic Cells 0.6749001996007984 0.3540419042110443 +CXCR4 True 3.0 Plasma Cells 0.36769759450171824 0.21305841207504272 +CXCR4 True 4.0 B Cells 0.21934713375796178 0.1675955355167389 +CXCR4 True 5.0 Macrophages 0.1761201761201761 0.1339031308889389 +DLL4 True 1.0 Endothelial Cells 0.476461038961039 0.2467532455921173 +DLL4 True 2.0 Pericytes 0.10634351428218128 0.07703722268342972 +DLL4 True 3.0 Myeloid Cells 0.04551045510455105 0.03198032081127167 +DLL4 True 4.0 11q13 Invasive Tumor Cells (Mitotic) 0.038180341186027617 0.03452477604150772 +DLL4 True 5.0 Plasma Cells 0.020618556701030927 0.019473081454634666 +EMCN True 1.0 Endothelial Cells 1.4728664192949907 0.6341604590415955 +EMCN True 2.0 Pericytes 0.32274020032150363 0.21491281688213348 +EMCN True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.09057676685621446 0.07514216005802155 +EMCN True 4.0 Myeloid Cells 0.06888068880688807 0.05781057849526405 +EMCN True 5.0 Plasma Cells 0.06758304696449026 0.05841924250125885 +FLT1 True 1.0 Endothelial Cells 1.5473098330241188 0.6168830990791321 +FLT1 True 2.0 Pericytes 0.3560034623469766 0.23519228398799896 +FLT1 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.24654752233956134 0.20633630454540253 +FLT1 True 4.0 Myeloid Cells 0.21648216482164823 0.16851168870925903 +FLT1 True 5.0 Apocrine Cells 0.15632754342431762 0.14640198647975922 +HES1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 0.4435418359057677 0.307879775762558 +HES1 True 2.0 Luminal-like Amorphous DCIS Cells 0.40067546822229044 0.2689591646194458 +HES1 True 3.0 11q13 Invasive Tumor Cells (G1/S) 0.33403538331929233 0.24136479198932648 +HES1 True 4.0 11q13 Invasive Tumor Cells 0.2922418639515273 0.21926729381084442 +HES1 True 5.0 Basal-like Structured DCIS Cells 0.2264840182648402 0.1742009073495865 +HEY1 True 1.0 Endothelial Cells 0.24570964749536178 0.15584415197372437 +HEY1 True 2.0 11q13 Invasive Tumor Cells (Mitotic) 0.17749796913078797 0.1486596316099167 +HEY1 True 3.0 Basal-like Structured DCIS Cells 0.1430365296803653 0.10844749212265015 +HEY1 True 4.0 Myoepithelial Cells 0.1268073003081299 0.10630480945110321 +HEY1 True 5.0 Myeloid Cells 0.10947109471094711 0.08733087033033371 +HSPG2 True 1.0 Endothelial Cells 5.104359925788497 0.8711734414100647 +HSPG2 True 2.0 CAFs, Invasive Associated 2.2671832041989504 0.6923269033432007 +HSPG2 True 3.0 Pericytes 1.1843699765055027 0.48237913846969604 +HSPG2 True 4.0 CAFs, DCIS Associated 0.8459618689141641 0.4324932396411896 +HSPG2 True 5.0 Myoepithelial Cells 0.5875799952595402 0.3209291398525238 +IL7R True 1.0 T Lymphocytes 0.20990271888251436 0.15851832926273346 +IL7R True 2.0 Myeloid Cells 0.05289052890528905 0.046740468591451645 +IL7R True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.05280259951259139 0.05158407613635063 +IL7R True 4.0 Apocrine Cells 0.04714640198511166 0.04466501250863075 +IL7R True 5.0 Dendritic Cells 0.046656686626746505 0.037425149232149124 +JAG1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 1.9065800162469537 0.7083671689033508 +JAG1 True 2.0 11q13 Invasive Tumor Cells 1.4774345680554688 0.6293959617614746 +JAG1 True 3.0 11q13 Invasive Tumor Cells (G1/S) 1.3336141533277168 0.5867733955383301 +JAG1 True 4.0 Luminal-like Amorphous DCIS Cells 1.0723825606386246 0.5086736083030701 +JAG1 True 5.0 Basal-like Structured DCIS Cells 0.6257990867579909 0.3481735289096832 +KDR True 1.0 Endothelial Cells 2.37569573283859 0.6372912526130676 +KDR True 2.0 Pericytes 0.6527760603437616 0.3185359239578247 +KDR True 3.0 CAFs, Invasive Associated 0.10547363159210198 0.06723318994045258 +KDR True 4.0 Myeloid Cells 0.09471094710947109 0.084870845079422 +KDR True 5.0 Basal-like Structured DCIS Cells 0.08367579908675798 0.06061643734574318 +LCK True 1.0 T Lymphocytes 0.6152407084060864 0.3986031413078308 +LCK True 2.0 B Cells 0.11544585987261147 0.0927547737956047 +LCK True 3.0 Plasma Cells 0.08476517754868271 0.06643757224082947 +LCK True 4.0 Myeloid Cells 0.06150061500615006 0.05166051536798477 +LCK True 5.0 Dendritic Cells 0.058632734530938126 0.04466067999601364 +LRP1 True 1.0 CAFs, Invasive Associated 2.662834291427143 0.7233191728591919 +LRP1 True 2.0 CAFs, DCIS Associated 2.585713116766222 0.7374191880226135 +LRP1 True 3.0 Dendritic Cells 1.0197105788423153 0.44386228919029236 +LRP1 True 4.0 Macrophages 0.9233359233359233 0.440559446811676 +LRP1 True 5.0 Myoepithelial Cells 0.4869637354823418 0.302085816860199 +MMP2 True 1.0 CAFs, DCIS Associated 1.4687423287783323 0.5307257771492004 +MMP2 True 2.0 CAFs, Invasive Associated 1.3129217695576105 0.4966258406639099 +MMP2 True 3.0 Endothelial Cells 0.2912801484230056 0.1832096427679062 +MMP2 True 4.0 Dendritic Cells 0.2657185628742515 0.15668663382530212 +MMP2 True 5.0 Myoepithelial Cells 0.2623844512917753 0.1821521669626236 +MMRN2 True 1.0 Endothelial Cells 1.2184601113172542 0.5637755393981934 +MMRN2 True 2.0 Pericytes 0.2594287127488562 0.17744527757167816 +MMRN2 True 3.0 Basal-like Structured DCIS Cells 0.06746575342465753 0.05319634824991226 +MMRN2 True 4.0 Myoepithelial Cells 0.06245555818914435 0.05131547898054123 +MMRN2 True 5.0 Mast Cells 0.04607046070460705 0.0379403792321682 +MYC True 1.0 Basal-like Structured DCIS Cells 1.5598173515981735 0.5699771642684937 +MYC True 2.0 Endothelial Cells 1.1174628942486085 0.4582560360431671 +MYC True 3.0 11q13 Invasive Tumor Cells (G1/S) 0.9334456613310868 0.45408591628074646 +MYC True 4.0 11q13 Invasive Tumor Cells 0.8824879755137734 0.44670185446739197 +MYC True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.8273761169780666 0.43013811111450195 +NOTCH1 True 1.0 Endothelial Cells 0.5613404452690167 0.35366418957710266 +NOTCH1 True 2.0 Basal-like Structured DCIS Cells 0.4221461187214612 0.263812780380249 +NOTCH1 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.30381803411860275 0.22542648017406464 +NOTCH1 True 4.0 Pericytes 0.22517620873006058 0.15951527655124664 +NOTCH1 True 5.0 Myoepithelial Cells 0.2188907324010429 0.15868689119815826 +NOTCH2 True 1.0 Apocrine Cells 2.1861042183622827 0.7171216011047363 +NOTCH2 True 2.0 11q13 Invasive Tumor Cells 1.3958398400899494 0.607002317905426 +NOTCH2 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 1.334281072298944 0.6255077123641968 +NOTCH2 True 4.0 Luminal-like Amorphous DCIS Cells 1.1538992938286767 0.5558028817176819 +NOTCH2 True 5.0 11q13 Invasive Tumor Cells (G1/S) 1.0602358887952823 0.5395956039428711 +NOTCH3 True 1.0 Pericytes 2.3809818226783728 0.5623840689659119 +NOTCH3 True 2.0 CAFs, Invasive Associated 1.1647088227943014 0.4973756670951843 +NOTCH3 True 3.0 Luminal-like Amorphous DCIS Cells 0.9322229045133559 0.4947804808616638 +NOTCH3 True 4.0 Endothelial Cells 0.7337662337662337 0.27516233921051025 +NOTCH3 True 5.0 Basal-like Structured DCIS Cells 0.6931506849315069 0.3960045576095581 +NOTCH4 True 1.0 Endothelial Cells 0.4457328385899815 0.28038033843040466 +NOTCH4 True 2.0 Myoepithelial Cells 0.10997866793078928 0.09042426943778992 +NOTCH4 True 3.0 Pericytes 0.08445653517991838 0.0650426596403122 +NOTCH4 True 4.0 Basal-like Structured DCIS Cells 0.07682648401826483 0.06255707889795303 +NOTCH4 True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.07636068237205523 0.06986190378665924 +PDGFRB True 1.0 CAFs, Invasive Associated 0.6135966008497875 0.3709072768688202 +PDGFRB True 2.0 Pericytes 0.42549771237789047 0.2529986500740051 +PDGFRB True 3.0 CAFs, DCIS Associated 0.32493249324932494 0.2368464171886444 +PDGFRB True 4.0 Endothelial Cells 0.15213358070500926 0.10227272659540176 +PDGFRB True 5.0 Dendritic Cells 0.05189620758483034 0.0416666679084301 +PECAM1 True 1.0 Endothelial Cells 4.5438311688311686 0.8918135166168213 +PECAM1 True 2.0 Plasma Cells 1.7445589919816724 0.6300114393234253 +PECAM1 True 3.0 Pericytes 1.0775318412266601 0.4703845679759979 +PECAM1 True 4.0 Dendritic Cells 0.7437624750499002 0.4149201512336731 +PECAM1 True 5.0 Macrophages 0.4421134421134421 0.28671327233314514 +PLAT True 1.0 11q13 Invasive Tumor Cells 8.869838840652132 0.956024706363678 +PLAT True 2.0 11q13 Invasive Tumor Cells (Mitotic) 7.280259951259139 0.9549146890640259 +PLAT True 3.0 11q13 Invasive Tumor Cells (G1/S) 6.233361415332772 0.9182813763618469 +PLAT True 4.0 Apocrine Cells 3.3101736972704714 0.8114144206047058 +PLAT True 5.0 Luminal-like Amorphous DCIS Cells 2.8183143997543754 0.6322535872459412 +RGS5 True 1.0 Pericytes 0.6418943984172129 0.3001112937927246 +RGS5 True 2.0 Endothelial Cells 0.5906771799628943 0.3025278151035309 +RGS5 True 3.0 CAFs, Invasive Associated 0.10747313171707074 0.06723318994045258 +RGS5 True 4.0 Myeloid Cells 0.07995079950799508 0.06519065052270889 +RGS5 True 5.0 Mast Cells 0.07859078590785908 0.0731707289814949 +SELP True 1.0 Endothelial Cells 0.7355055658627088 0.259508341550827 +SELP True 2.0 Pericytes 0.10980586125881044 0.07270928472280502 +SELP True 3.0 T Lymphocytes 0.06023946121227239 0.050511348992586136 +SELP True 4.0 Myeloid Cells 0.05166051660516605 0.04428044334053993 +SELP True 5.0 Plasma Cells 0.043528064146620846 0.03665521368384361 +SERPINE1 True 1.0 CAFs, Invasive Associated 0.3504123969007748 0.20569857954978943 +SERPINE1 True 2.0 Myoepithelial Cells 0.05724105238208106 0.03507940098643303 +SERPINE1 True 3.0 Endothelial Cells 0.05322356215213358 0.04012059420347214 +SERPINE1 True 4.0 CAFs, DCIS Associated 0.04107683495622289 0.03358972445130348 +SERPINE1 True 5.0 Dendritic Cells 0.036926147704590816 0.03168662637472153 +THBD True 1.0 Endothelial Cells 0.8287337662337663 0.40491652488708496 +THBD True 2.0 Pericytes 0.2860145913194015 0.18770866096019745 +THBD True 3.0 Dendritic Cells 0.1217564870259481 0.09356287121772766 +THBD True 4.0 CAFs, Invasive Associated 0.10847288177955511 0.0794801265001297 +THBD True 5.0 Myeloid Cells 0.08487084870848709 0.07503075152635574 +THBS2 True 1.0 CAFs, Invasive Associated 1.8375406148462885 0.5576105713844299 +THBS2 True 2.0 CAFs, DCIS Associated 1.6160297847966616 0.5173472166061401 +THBS2 True 3.0 Dendritic Cells 0.1317365269461078 0.071856290102005 +THBS2 True 4.0 CXCL14+ Fibroblasts 0.11588330632090761 0.07698541134595871 +THBS2 True 5.0 Pericytes 0.1151230369729195 0.07122542709112167 +TRAC True 1.0 T Lymphocytes 2.8600648540783236 0.7904714345932007 +TRAC True 2.0 B Cells 0.6871019108280255 0.3626592457294464 +TRAC True 3.0 Plasma Cells 0.33791523482245134 0.1477663218975067 +TRAC True 4.0 Dendritic Cells 0.24176646706586827 0.1230039894580841 +TRAC True 5.0 CAFs, Invasive Associated 0.15571107223194203 0.10172457247972488 +VWF True 1.0 Endothelial Cells 6.707908163265306 0.8781307935714722 +VWF True 2.0 Pericytes 1.29108445653518 0.4304439127445221 +VWF True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.11169780666125101 0.09423232823610306 +VWF True 4.0 Dendritic Cells 0.11052894211576847 0.05913173779845238 +VWF True 5.0 Mast Cells 0.10840108401084012 0.08130080997943878 diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_false_positive_controls.tsv b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_false_positive_controls.tsv new file mode 100644 index 0000000..8443750 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_false_positive_controls.tsv @@ -0,0 +1,36 @@ +axis_id control_type observed expected_or_control_mean z_or_rank p_or_percentile note +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_abundance_null 13942.0 9916.101448337911 40.577088952341676 0.0 cell-type-label abundance null for graph edge count +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 4.0 3299.0 4.0 0.9990906335253107 rank percentile against all LR pairs in the same sender-receiver cell-type pair +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_abundance_null 11379.0 3280.889960425034 141.55074144031974 0.0 cell-type-label abundance null for graph edge count +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_abundance_null 11604.0 9219.306750089676 24.92068208259856 2.220471678964988e-137 cell-type-label abundance null for graph edge count +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_abundance_null 21212.0 3024.318857794739 331.09056328473696 0.0 cell-type-label abundance null for graph edge count +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_abundance_null 423716.0 192905.1692550145 567.2684147856648 0.0 cell-type-label abundance null for graph edge count +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_sender_receiver 8.0 3299.0 8.0 0.9978781448923917 rank percentile against all LR pairs in the same sender-receiver cell-type pair +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-SELP|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.690919789894645 0.1174789121765555 6.674917611699146 1.0 matched by global mean expression and detection fraction +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated matched_gene_expression_control 0.8904867455342288 0.1132557384471686 11.234674798948532 1.0 matched by global mean expression and detection fraction +MMRN2-CD93|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.7291144166273554 0.13022764647610297 6.198278570208171 1.0 matched by global mean expression and detection fraction +DLL4-NOTCH3|Endothelial Cells->Pericytes matched_gene_expression_control 0.6103430039507179 0.10700066735274656 8.301941713984622 1.0 matched by global mean expression and detection fraction +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes matched_gene_expression_control 0.7850757124806441 0.1029738649850631 11.218977606863426 1.0 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes matched_gene_expression_control 0.5987173848132842 0.10702942070910819 9.860708047779738 1.0 matched by global mean expression and detection fraction +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells matched_gene_expression_control 0.6593758884575077 0.6351644259334726 0.3126368933035661 0.576 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes component_ablation_max_rank 20.0 7.0 20.0 worst and best rank after removing one score component +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes component_ablation_max_rank 615.0 8.0 615.0 worst and best rank after removing one score component +DLL4-NOTCH3|Endothelial Cells->Pericytes component_ablation_max_rank 76.0 20.0 76.0 worst and best rank after removing one score component +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells component_ablation_max_rank 329.0 30.0 329.0 worst and best rank after removing one score component +MMRN2-CD93|Endothelial Cells->Endothelial Cells component_ablation_max_rank 13.0 6.0 13.0 worst and best rank after removing one score component +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated component_ablation_max_rank 614.0 2.0 614.0 worst and best rank after removing one score component +VWF-SELP|Endothelial Cells->Endothelial Cells component_ablation_max_rank 16.0 1.0 16.0 worst and best rank after removing one score component diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_matched_gene_controls.tsv b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_matched_gene_controls.tsv new file mode 100644 index 0000000..59725eb --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_matched_gene_controls.tsv @@ -0,0 +1,8 @@ +axis_id matched_gene_status n_controls observed_expression_specificity_score control_mean control_sd matched_gene_z matched_gene_percentile +VWF-SELP|Endothelial Cells->Endothelial Cells success 250 0.690919789894645 0.1174789121765555 0.08590980609453787 6.674917611699146 1.0 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 250 0.8904867455342288 0.1132557384471686 0.06918144236447345 11.234674798948532 1.0 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 250 0.7291144166273554 0.13022764647610297 0.09662146729412627 6.198278570208171 1.0 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 250 0.6103430039507179 0.10700066735274656 0.060629471265751134 8.301941713984622 1.0 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 250 0.7850757124806441 0.1029738649850631 0.06079893118587669 11.218977606863426 1.0 +CD48-CD2|T Lymphocytes->T Lymphocytes success 250 0.5987173848132842 0.10702942070910819 0.04986335278579571 9.860708047779738 1.0 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 250 0.6593758884575077 0.6351644259334726 0.07744275561402209 0.3126368933035661 0.576 diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_spatial_null_summary.tsv b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_spatial_null_summary.tsv new file mode 100644 index 0000000..88f4c43 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_spatial_null_summary.tsv @@ -0,0 +1,8 @@ +axis_id observed_cross_edge_count expected_cross_edge_count_abundance_null cross_edge_enrichment_fold cross_edge_enrichment_z cross_edge_enrichment_p_approx local_contact contact_coverage within_sender_receiver_rank within_sender_receiver_n within_sender_receiver_percentile within_lr_pair_rank within_lr_pair_n within_lr_pair_percentile +VWF-SELP|Endothelial Cells->Endothelial Cells 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.2912449657481761 0.1111198059316065 1 3299 1.0 1 400 1.0 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 13942 9916.101448337911 1.4059961036740796 40.577088952341676 0.0 0.3461937505325735 0.1319036006311863 1 3299 1.0 1 400 1.0 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.1484661470807383 0.0288754988653259 4 3299 0.9990906335253107 1 400 1.0 +DLL4-NOTCH3|Endothelial Cells->Pericytes 11379 3280.889960425034 3.4682662744732435 141.55074144031974 0.0 0.135465098207694 0.0303190087002372 1 3299 1.0 1 400 1.0 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 11604 9219.306750089676 1.258662968328625 24.92068208259856 2.220471678964988e-137 0.1684304172162009 0.0450706652878317 1 3299 1.0 1 400 1.0 +CD48-CD2|T Lymphocytes->T Lymphocytes 21212 3024.318857794739 7.0138107115687145 331.09056328473696 0.0 0.1241603897223811 0.0154158023760135 1 3299 1.0 1 400 1.0 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 423716 192905.1692550145 2.1964989410929725 567.2684147856648 0.0 0.1231934200799743 0.0168391092146626 8 3299 0.9978781448923917 1 400 1.0 diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_validation_evidence.tsv b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_validation_evidence.tsv new file mode 100644 index 0000000..4c1c8fd --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/tables/topolink_cci_validation_evidence.tsv @@ -0,0 +1,15 @@ +axis_id biology_label ligand receptor sender_celltype receiver_celltype CCI_score global_rank sender_anchor receiver_anchor structure_bridge sender_expr receiver_expr local_contact_x prior_confidence cross_edge_count sender receiver ligand_sender_mean ligand_sender_detection_fraction ligand_sender_celltype_rank ligand_sender_specificity_ratio receptor_receiver_mean receptor_receiver_detection_fraction receptor_receiver_celltype_rank receptor_receiver_specificity_ratio observed_cross_edge_count expected_cross_edge_count_abundance_null cross_edge_enrichment_fold cross_edge_enrichment_z cross_edge_enrichment_p_approx local_contact_y contact_coverage within_sender_receiver_rank within_sender_receiver_n within_sender_receiver_percentile within_lr_pair_rank within_lr_pair_n within_lr_pair_percentile matched_gene_status n_controls observed_expression_specificity_score control_mean control_sd matched_gene_z matched_gene_percentile max_rank_after_component_removal min_rank_after_component_removal cross_method_exact_count cross_method_same_lr_count cross_method_same_sender_receiver_count supporting_methods_exact supporting_methods_same_lr target_panel_present_n receiver_context_panel_score receiver_context_panel_genes expression_support spatial_abundance_null_support matched_gene_control_support component_ablation_support cross_method_support receiver_context_support support_count evidence_class axis_label +VWF-SELP|Endothelial Cells->Endothelial Cells WPB / endothelial activation VWF SELP Endothelial Cells Endothelial Cells 0.7854081595451057 1 0.939155377105368 0.8581763436107446 1.0 1.0 1.0 0.2912449657481761 1.0 12779 Endothelial Cells Endothelial Cells 6.707908163265306 0.8781307935714722 1 1.0 0.7355055658627088 0.259508341550827 1 1.0 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.2912449657481761 0.1111198059316065 1 3299 1.0 1 400 1.0 success 250 0.690919789894645 0.1174789121765555 0.08590980609453787 6.674917611699146 1.0 16 1 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 6 0.6656207262750022 VWF,SELP,ANGPT2,THBD,PLAT,SERPINE1 True True True True True True 6 strong "VWF-SELP +Endothelial Cells -> Endothelial Cells" +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated vascular-stromal matrix/scavenger axis VWF LRP1 Endothelial Cells CAFs, DCIS Associated 0.7148067513709494 5 0.939155377105368 0.6455155104503945 0.6355774498689515 1.0 1.0 0.3461937505325735 1.0 13942 Endothelial Cells CAFs, DCIS Associated 6.707908163265306 0.8781307935714722 1 1.0 2.585713116766222 0.7374191880226135 2 0.971037936942149 13942 9916.101448337911 1.4059961036740796 40.577088952341676 0.0 0.3461937505325735 0.1319036006311863 1 3299 1.0 1 400 1.0 success 250 0.8904867455342288 0.1132557384471686 0.06918144236447345 11.234674798948532 1.0 614 2 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 7 0.5161052675482147 VWF,LRP1,HSPG2,COL4A1,COL4A2,MMP2,THBS2 True True True False True True 5 strong "VWF-LRP1 +Endothelial Cells -> CAFs, DCIS Associated" +MMRN2-CD93|Endothelial Cells->Endothelial Cells CD93-MMRN2 angiogenesis MMRN2 CD93 Endothelial Cells Endothelial Cells 0.7055697517643245 6 0.9751523688982604 0.8521965156573951 1.0 1.0 1.0 0.1484661470807383 1.0 12779 Endothelial Cells Endothelial Cells 1.2184601113172542 0.5637755393981934 1 1.0 0.9689239332096475 0.5012755393981934 1 1.0 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.1484661470807383 0.0288754988653259 4 3299 0.9990906335253107 1 400 1.0 success 250 0.7291144166273554 0.13022764647610297 0.09662146729412627 6.198278570208171 1.0 13 6 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 7 1.0 MMRN2,CD93,CLEC14A,KDR,FLT1,PECAM1,EMCN True True True True True True 6 strong "MMRN2-CD93 +Endothelial Cells -> Endothelial Cells" +CD48-CD2|T Lymphocytes->T Lymphocytes T-cell adhesion/co-stimulation CD48 CD2 T Lymphocytes T Lymphocytes 0.6870622750035398 13 0.9214912429371794 0.9193953048895664 1.0 1.0 1.0 0.1241603897223811 1.0 21212 T Lymphocytes T Lymphocytes 0.5604888999750561 0.37989524006843567 1 1.0 0.49837864804190574 0.3382389545440674 1 1.0 21212 3024.318857794739 7.0138107115687145 331.09056328473696 0.0 0.1241603897223811 0.0154158023760135 1 3299 1.0 1 400 1.0 success 250 0.5987173848132842 0.10702942070910819 0.04986335278579571 9.860708047779738 1.0 20 7 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 7 1.0 CD48,CD2,CD3D,CD3E,TRAC,IL7R,LCK True True True True True True 6 strong "CD48-CD2 +T Lymphocytes -> T Lymphocytes" +DLL4-NOTCH3|Endothelial Cells->Pericytes endothelial-pericyte Notch DLL4 NOTCH3 Endothelial Cells Pericytes 0.6628108852003319 20 0.8999695474149415 0.8544260293908458 0.9385210026241833 1.0 0.8672894033034337 0.135465098207694 1.0 11379 Endothelial Cells Pericytes 0.476461038961039 0.2467532455921173 1 1.0 2.3809818226783728 0.5623840689659119 1 1.0 11379 3280.889960425034 3.4682662744732435 141.55074144031974 0.0 0.135465098207694 0.0303190087002372 1 3299 1.0 1 400 1.0 success 250 0.6103430039507179 0.10700066735274656 0.060629471265751134 8.301941713984622 1.0 76 20 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 8 0.48688694950414185 DLL4,NOTCH3,NOTCH4,JAG1,HEY1,HES1,PDGFRB,RGS5 True True True True True False 5 strong "DLL4-NOTCH3 +Endothelial Cells -> Pericytes" +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes CAF-immune chemokine recruitment CXCL12 CXCR4 CAFs, DCIS Associated T Lymphocytes 0.6338817490290192 29 0.8401391037337905 0.929067454422166 0.493435580121531 1.0 1.0 0.1684304172162009 1.0 11604 CAFs, DCIS Associated T Lymphocytes 3.649660420587513 0.7872514724731445 1 1.0 0.9085806934397606 0.4825392961502075 1 1.0 11604 9219.306750089676 1.258662968328625 24.92068208259856 2.220471678964988e-137 0.1684304172162009 0.0450706652878317 1 3299 1.0 1 400 1.0 success 250 0.7850757124806441 0.1029738649850631 0.06079893118587669 11.218977606863426 1.0 615 8 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 8 0.7664489835769633 CXCL12,CXCR4,CXCR3,CCL19,CCL21,CD3D,CD3E,IL7R True True True False True True 5 strong "CXCL12-CXCR4 +CAFs, DCIS Associated -> T Lymphocytes" +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells tumor-intrinsic Notch signaling JAG1 NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6167922205938116 41 0.7293068717997298 0.6128235489150379 1.0 1.0 1.0 0.1231934200799743 1.0 423716 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 1.4774345680554688 0.6293959617614746 2 0.7749134866963281 1.3958398400899494 0.607002317905426 2 0.6385056249219633 423716 192905.1692550145 2.1964989410929725 567.2684147856648 0.0 0.1231934200799743 0.0168391092146626 8 3299 0.9978781448923917 1 400 1.0 success 250 0.6593758884575077 0.6351644259334726 0.07744275561402209 0.3126368933035661 0.576 329 30 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 7 0.5860530033828537 JAG1,NOTCH2,NOTCH1,HES1,HEY1,MYC,CCND1 True True False False True True 4 moderate "JAG1-NOTCH2 +11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells" diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/topolink_cci_false_positive_controls.tsv b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/topolink_cci_false_positive_controls.tsv new file mode 100644 index 0000000..8443750 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/topolink_cci_false_positive_controls.tsv @@ -0,0 +1,36 @@ +axis_id control_type observed expected_or_control_mean z_or_rank p_or_percentile note +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_abundance_null 13942.0 9916.101448337911 40.577088952341676 0.0 cell-type-label abundance null for graph edge count +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 4.0 3299.0 4.0 0.9990906335253107 rank percentile against all LR pairs in the same sender-receiver cell-type pair +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_abundance_null 11379.0 3280.889960425034 141.55074144031974 0.0 cell-type-label abundance null for graph edge count +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_abundance_null 11604.0 9219.306750089676 24.92068208259856 2.220471678964988e-137 cell-type-label abundance null for graph edge count +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_abundance_null 21212.0 3024.318857794739 331.09056328473696 0.0 cell-type-label abundance null for graph edge count +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_abundance_null 423716.0 192905.1692550145 567.2684147856648 0.0 cell-type-label abundance null for graph edge count +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_sender_receiver 8.0 3299.0 8.0 0.9978781448923917 rank percentile against all LR pairs in the same sender-receiver cell-type pair +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-SELP|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.690919789894645 0.1174789121765555 6.674917611699146 1.0 matched by global mean expression and detection fraction +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated matched_gene_expression_control 0.8904867455342288 0.1132557384471686 11.234674798948532 1.0 matched by global mean expression and detection fraction +MMRN2-CD93|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.7291144166273554 0.13022764647610297 6.198278570208171 1.0 matched by global mean expression and detection fraction +DLL4-NOTCH3|Endothelial Cells->Pericytes matched_gene_expression_control 0.6103430039507179 0.10700066735274656 8.301941713984622 1.0 matched by global mean expression and detection fraction +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes matched_gene_expression_control 0.7850757124806441 0.1029738649850631 11.218977606863426 1.0 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes matched_gene_expression_control 0.5987173848132842 0.10702942070910819 9.860708047779738 1.0 matched by global mean expression and detection fraction +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells matched_gene_expression_control 0.6593758884575077 0.6351644259334726 0.3126368933035661 0.576 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes component_ablation_max_rank 20.0 7.0 20.0 worst and best rank after removing one score component +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes component_ablation_max_rank 615.0 8.0 615.0 worst and best rank after removing one score component +DLL4-NOTCH3|Endothelial Cells->Pericytes component_ablation_max_rank 76.0 20.0 76.0 worst and best rank after removing one score component +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells component_ablation_max_rank 329.0 30.0 329.0 worst and best rank after removing one score component +MMRN2-CD93|Endothelial Cells->Endothelial Cells component_ablation_max_rank 13.0 6.0 13.0 worst and best rank after removing one score component +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated component_ablation_max_rank 614.0 2.0 614.0 worst and best rank after removing one score component +VWF-SELP|Endothelial Cells->Endothelial Cells component_ablation_max_rank 16.0 1.0 16.0 worst and best rank after removing one score component diff --git a/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/topolink_cci_validation_scoreboard.md b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/topolink_cci_validation_scoreboard.md new file mode 100644 index 0000000..061f27a --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_collected/topolink_cci_validation_20260428_outputs/topolink_cci_validation_scoreboard.md @@ -0,0 +1,41 @@ +# TopoLink-CCI validation evidence scoreboard + +This PDC run applies the computational false-positive-control logic used by classic CCC/LR papers: expression specificity, spatial/label nulls, matched-gene controls, component ablation, cross-method triangulation, and receiver-context support. It is computational evidence, not wet-lab proof. + +## Evidence classes + +- Strong axes: 6 +- Moderate axes: 1 +- Hypothesis-only axes: 0 + +axis_label biology_label CCI_score global_rank evidence_class support_count cross_method_same_lr_count matched_gene_percentile cross_edge_enrichment_z max_rank_after_component_removal +"VWF-SELP +Endothelial Cells -> Endothelial Cells" WPB / endothelial activation 0.7854081595451057 1 strong 6 7 1.0 157.09499064265975 16 +"VWF-LRP1 +Endothelial Cells -> CAFs, DCIS Associated" vascular-stromal matrix/scavenger axis 0.7148067513709494 5 strong 5 7 1.0 40.577088952341676 614 +"MMRN2-CD93 +Endothelial Cells -> Endothelial Cells" CD93-MMRN2 angiogenesis 0.7055697517643245 6 strong 6 7 1.0 157.09499064265975 13 +"CD48-CD2 +T Lymphocytes -> T Lymphocytes" T-cell adhesion/co-stimulation 0.6870622750035398 13 strong 6 7 1.0 331.09056328473696 20 +"DLL4-NOTCH3 +Endothelial Cells -> Pericytes" endothelial-pericyte Notch 0.6628108852003319 20 strong 5 7 1.0 141.55074144031974 76 +"CXCL12-CXCR4 +CAFs, DCIS Associated -> T Lymphocytes" CAF-immune chemokine recruitment 0.6338817490290192 29 strong 5 7 1.0 24.92068208259856 615 +"JAG1-NOTCH2 +11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells" tumor-intrinsic Notch signaling 0.6167922205938116 41 moderate 4 7 0.576 567.2684147856648 329 + + +## Control interpretation + +- `spatial_abundance_null`: compares observed sender-receiver graph edges with a label-abundance null; it is conservative about exact geometry but catches cell-type-pair edge enrichment. +- `matched_gene_control`: compares ligand/receptor sender-receiver expression specificity with genes matched by global mean and detection. +- `lr_label_permutation`: reports where the candidate ranks within the same sender-receiver cell-type pair and within the same LR pair across cell-type pairs. +- `component_ablation`: recomputes geometric-mean LR scores after removing one pyXenium component at a time. + +## References to validation patterns + +- CellPhoneDB: curated LR database, complex filtering, and cell-label permutation specificity. +- CellChat: mass-action communication probability, curated cofactors/complexes, and label permutation. +- NicheNet: downstream receiver target-gene support rather than co-expression alone. +- stLearn/SpatialDM/Squidpy: spatially constrained LR evidence and permutation/random-pair controls. +- LIANA benchmark: multi-method consensus and rank aggregation because no single LR score is ground truth. diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/logs/run.stderr.log b/benchmarking/cci_2026_atera/a100_validation_v2_collected/logs/run.stderr.log new file mode 100644 index 0000000..2ffc4c6 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/logs/run.stderr.log @@ -0,0 +1,23 @@ + Command being timed: "/home/taobo.hu/miniconda3/bin/conda run -n pyx-cci-pyxenium python /data/taobo.hu/topolink_cci_validation_20260428_v2/scripts/topolink_cci_validation_v2.py --root /data/taobo.hu/topolink_cci_benchmark_2026-04 --output-dir /data/taobo.hu/topolink_cci_validation_20260428_v2/outputs --n-label-permutations 500 --n-spatial-permutations 300 --n-spatial-matched-pairs 120 --n-matched-controls 250 --n-downstream-permutations 120 --n-bootstraps 5 --k-neighbors 10 --seed 20260428" + User time (seconds): 80.13 + System time (seconds): 54.35 + Percent of CPU this job got: 186% + Elapsed (wall clock) time (h:mm:ss or m:ss): 1:12.28 + Average shared text size (kbytes): 0 + Average unshared data size (kbytes): 0 + Average stack size (kbytes): 0 + Average total size (kbytes): 0 + Maximum resident set size (kbytes): 8977084 + Average resident set size (kbytes): 0 + Major (requiring I/O) page faults: 480 + Minor (reclaiming a frame) page faults: 1243039 + Voluntary context switches: 9968 + Involuntary context switches: 17531 + Swaps: 0 + File system inputs: 1635344 + 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zEe;1yqNJg}0MeTrAps7Ed-0%s!?#4@kW1`O$UA-=88)e%X!&vppt9AA1H*7p&?2wc z5!)%KhHJmNBk^ T Lymphocytes + +- Biology label: T-cell adhesion/co-stimulation +- TopoLink-CCI_score: 0.687062 +- pyXenium rank: 13 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.011627906976744186 +- `matched_gene_z`: 9.860708047779738 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 11.544674396514893 +- `downstream_target_fdr`: 0.008323424494649227 +- `received_signal_target_spearman`: 0.4228849179250702 +- `cross_method_exact_count`: 7 +- `cross_method_same_lr_count`: 7 +- `bootstrap_rank_median`: 5.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/CXCL12_CXCR4_CAFs_DCIS_Associated_T_Lymphocytes.md b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/CXCL12_CXCR4_CAFs_DCIS_Associated_T_Lymphocytes.md new file mode 100644 index 0000000..d1d4bf4 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/CXCL12_CXCR4_CAFs_DCIS_Associated_T_Lymphocytes.md @@ -0,0 +1,25 @@ +# CXCL12-CXCR4: CAFs, DCIS Associated -> T Lymphocytes + +- Biology label: CAF-immune chemokine recruitment +- TopoLink-CCI_score: 0.633882 +- pyXenium rank: 29 +- Evidence class: strong +- Supported layers: 7/9 +- Interpretation: strong: 7/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.5813953488372093 +- `matched_gene_z`: 11.218977606863426 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 6.800970241427422 +- `downstream_target_fdr`: 0.025494276795005204 +- `received_signal_target_spearman`: 0.4955612441859473 +- `cross_method_exact_count`: 7 +- `cross_method_same_lr_count`: 7 +- `bootstrap_rank_median`: 4.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/DLL4_NOTCH3_Endothelial_Cells_Pericytes.md b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/DLL4_NOTCH3_Endothelial_Cells_Pericytes.md new file mode 100644 index 0000000..d5ec4cf --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/DLL4_NOTCH3_Endothelial_Cells_Pericytes.md @@ -0,0 +1,25 @@ +# DLL4-NOTCH3: Endothelial Cells -> Pericytes + +- Biology label: endothelial-pericyte Notch +- TopoLink-CCI_score: 0.662811 +- pyXenium rank: 20 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 8.301941713984622 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 2.61274266988039 +- `downstream_target_fdr`: 0.025494276795005204 +- `received_signal_target_spearman`: 0.721750076253441 +- `cross_method_exact_count`: 7 +- `cross_method_same_lr_count`: 7 +- `bootstrap_rank_median`: 6.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/JAG1_NOTCH2_11q13_Invasive_Tumor_Cells_11q13_Invasive_Tumor_Cells.md b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/JAG1_NOTCH2_11q13_Invasive_Tumor_Cells_11q13_Invasive_Tumor_Cells.md new file mode 100644 index 0000000..62f9a06 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/JAG1_NOTCH2_11q13_Invasive_Tumor_Cells_11q13_Invasive_Tumor_Cells.md @@ -0,0 +1,25 @@ +# JAG1-NOTCH2: 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells + +- Biology label: tumor-intrinsic Notch signaling +- TopoLink-CCI_score: 0.616792 +- pyXenium rank: 41 +- Evidence class: strong +- Supported layers: 6/9 +- Interpretation: strong: 6/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 0.3126368933035661 +- `matched_gene_percentile`: 0.576 +- `downstream_target_score`: 1.5110729336738586 +- `downstream_target_fdr`: 0.6076099881093936 +- `received_signal_target_spearman`: 0.5874875426315861 +- `cross_method_exact_count`: 7 +- `cross_method_same_lr_count`: 7 +- `bootstrap_rank_median`: 7.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/MMRN2_CD93_Endothelial_Cells_Endothelial_Cells.md b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/MMRN2_CD93_Endothelial_Cells_Endothelial_Cells.md new file mode 100644 index 0000000..c2ac74d --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/MMRN2_CD93_Endothelial_Cells_Endothelial_Cells.md @@ -0,0 +1,25 @@ +# MMRN2-CD93: Endothelial Cells -> Endothelial Cells + +- Biology label: CD93-MMRN2 angiogenesis +- TopoLink-CCI_score: 0.70557 +- pyXenium rank: 6 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 6.198278570208171 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 11.116392135620117 +- `downstream_target_fdr`: 0.008323424494649227 +- `received_signal_target_spearman`: 0.4506380910061747 +- `cross_method_exact_count`: 7 +- `cross_method_same_lr_count`: 7 +- `bootstrap_rank_median`: 2.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/VWF_LRP1_Endothelial_Cells_CAFs_DCIS_Associated.md b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/VWF_LRP1_Endothelial_Cells_CAFs_DCIS_Associated.md new file mode 100644 index 0000000..7c4d936 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/VWF_LRP1_Endothelial_Cells_CAFs_DCIS_Associated.md @@ -0,0 +1,25 @@ +# VWF-LRP1: Endothelial Cells -> CAFs, DCIS Associated + +- Biology label: vascular-stromal matrix/scavenger axis +- TopoLink-CCI_score: 0.714807 +- pyXenium rank: 5 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 11.234674798948532 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 2.588202246597835 +- `downstream_target_fdr`: 0.029131985731272295 +- `received_signal_target_spearman`: 0.6575063035069829 +- `cross_method_exact_count`: 7 +- `cross_method_same_lr_count`: 7 +- `bootstrap_rank_median`: 3.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/VWF_SELP_Endothelial_Cells_Endothelial_Cells.md b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/VWF_SELP_Endothelial_Cells_Endothelial_Cells.md new file mode 100644 index 0000000..3b8cfe4 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/reports/validation_cards/VWF_SELP_Endothelial_Cells_Endothelial_Cells.md @@ -0,0 +1,25 @@ +# VWF-SELP: Endothelial Cells -> Endothelial Cells + +- Biology label: WPB / endothelial activation +- TopoLink-CCI_score: 0.785408 +- pyXenium rank: 1 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 6.674917611699146 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 6.738417175908883 +- `downstream_target_fdr`: 0.027184466019417475 +- `received_signal_target_spearman`: 0.6283646829850982 +- `cross_method_exact_count`: 7 +- `cross_method_same_lr_count`: 7 +- `bootstrap_rank_median`: 1.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/run_summary.json b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/run_summary.json new file mode 100644 index 0000000..4c9940b --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/run_summary.json @@ -0,0 +1,15 @@ +{ + "status": "success", + "runtime_seconds": 69.638, + "n_scores": 1319600, + "n_target_axes": 7, + "evidence_class_counts": { + "strong": 7 + }, + "outputs": { + "evidence": "/data/taobo.hu/topolink_cci_validation_20260428_v2/outputs/tables/topolink_cci_validation_v2_evidence.tsv", + "controls": "/data/taobo.hu/topolink_cci_validation_20260428_v2/outputs/tables/topolink_cci_validation_v2_false_positive_controls.tsv", + "report": "/data/taobo.hu/topolink_cci_validation_20260428_v2/outputs/reports/topolink_cci_validation_v2_report.md", + "figure": "/data/taobo.hu/topolink_cci_validation_20260428_v2/outputs/figures/topolink_cci_validation_v2_evidence_matrix.png" + } +} \ No newline at end of file diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/bootstrap_stability_repeats.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/bootstrap_stability_repeats.tsv new file mode 100644 index 0000000..ec48a81 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/bootstrap_stability_repeats.tsv @@ -0,0 +1,36 @@ +axis_id bootstrap_id bootstrap_validation_score bootstrap_rank +VWF-SELP|Endothelial Cells->Endothelial Cells 1 2.5294846037115666 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 1 2.4775096018215743 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 1 2.492760816959846 2 +DLL4-NOTCH3|Endothelial Cells->Pericytes 1 1.6468683289549024 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 1 1.9733111259538318 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 1 1.9415515823178238 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 1 1.0242960341055216 7 +VWF-SELP|Endothelial Cells->Endothelial Cells 2 2.5171162335011186 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 2 2.473767032097854 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 2 2.4772141734693474 2 +DLL4-NOTCH3|Endothelial Cells->Pericytes 2 1.6386355219882283 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 2 1.9703233264062612 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 2 1.9142494261725485 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 2 1.0252292828485567 7 +VWF-SELP|Endothelial Cells->Endothelial Cells 3 2.5103975259149602 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 3 2.471284260537661 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 3 2.4798530594772266 2 +DLL4-NOTCH3|Endothelial Cells->Pericytes 3 1.6483774045144926 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 3 1.972576240962361 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 3 1.941759991358487 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 3 1.0218695412958279 7 +VWF-SELP|Endothelial Cells->Endothelial Cells 4 2.5250901302802897 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 4 2.476756834260751 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 4 2.4928706890779577 2 +DLL4-NOTCH3|Endothelial Cells->Pericytes 4 1.6169876523117452 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 4 1.978781084743746 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 4 1.9076236376944962 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 4 1.02607284368184 7 +VWF-SELP|Endothelial Cells->Endothelial Cells 5 2.541566594354046 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 5 2.4811317184193578 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 5 2.473281442649322 3 +DLL4-NOTCH3|Endothelial Cells->Pericytes 5 1.6233431845634525 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 5 1.9747722688717537 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 5 1.921048420646914 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 5 1.025995534799094 7 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/bootstrap_stability_summary.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/bootstrap_stability_summary.tsv new file mode 100644 index 0000000..7ba975b --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/bootstrap_stability_summary.tsv @@ -0,0 +1,8 @@ +axis_id bootstrap_rank_median bootstrap_rank_iqr bootstrap_score_mean bootstrap_score_sd bootstrap_n +CD48-CD2|T Lymphocytes->T Lymphocytes 5.0 0.0 1.925246611638054 0.015713655566381553 5 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 4.0 0.0 1.9739528093875909 0.0031410030934122366 5 +DLL4-NOTCH3|Endothelial Cells->Pericytes 6.0 0.0 1.634842418466564 0.014082178981952163 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 7.0 0.0 1.0246926473461682 0.0017333252101482156 5 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 2.0 0.0 2.48319603632674 0.009087646555426442 5 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 3.0 0.0 2.4760898894274397 0.003754003645322219 5 +VWF-SELP|Endothelial Cells->Endothelial Cells 1.0 0.0 2.5247310175523965 0.011933106345753796 5 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/cell_label_permutation.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/cell_label_permutation.tsv new file mode 100644 index 0000000..e4e88df --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/cell_label_permutation.tsv @@ -0,0 +1,8 @@ +axis_id cell_label_perm_status cell_label_comm_prob cell_label_perm_mean cell_label_perm_sd cell_label_perm_z cell_label_perm_p cell_label_perm_n cell_label_perm_fdr +VWF-SELP|Endothelial Cells->Endothelial Cells success 4.933703899383545 0.02757341218739748 0.002595310303671029 1890.383003626386 0.001996007984031936 500 0.001996007984031936 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 17.3447265625 0.2998358674645424 0.016262341095952152 1048.1203533037499 0.001996007984031936 500 0.001996007984031936 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 1.1805951595306396 0.008823287986218929 0.0006422116967277436 1824.588180992251 0.001996007984031936 500 0.001996007984031936 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 1.1344451904296875 0.022496088080108164 0.0018236492093399003 609.7384829575133 0.001996007984031936 500 0.001996007984031936 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 3.3160109519958496 0.08272893443703651 0.004327497961377857 747.1481318801938 0.001996007984031936 500 0.001996007984031936 +CD48-CD2|T Lymphocytes->T Lymphocytes success 0.2793356776237488 0.0026596546296495946 0.00022015248609680323 1256.7472114416275 0.001996007984031936 500 0.001996007984031936 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 2.0622618198394775 0.7131924320459366 0.005215585602508038 258.6611534368852 0.001996007984031936 500 0.001996007984031936 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/component_ablation.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/component_ablation.tsv new file mode 100644 index 0000000..ede4740 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/component_ablation.tsv @@ -0,0 +1,50 @@ +axis_id removed_component score_without_component rank_without_component +VWF-SELP|Endothelial Cells->Endothelial Cells sender_anchor 0.7936685312319989 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated sender_anchor 0.7223245865106046 8 +MMRN2-CD93|Endothelial Cells->Endothelial Cells sender_anchor 0.7085348212720359 13 +DLL4-NOTCH3|Endothelial Cells->Pericytes sender_anchor 0.6745564828093611 25 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes sender_anchor 0.6525538738821847 36 +CD48-CD2|T Lymphocytes->T Lymphocytes sender_anchor 0.6964889406614021 16 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells sender_anchor 0.650110468858211 40 +VWF-SELP|Endothelial Cells->Endothelial Cells receiver_anchor 0.805686300976693 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated receiver_anchor 0.7689017668792069 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells receiver_anchor 0.7246305722691555 9 +DLL4-NOTCH3|Endothelial Cells->Pericytes receiver_anchor 0.6804202200885041 21 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes receiver_anchor 0.6417024502434168 49 +CD48-CD2|T Lymphocytes->T Lymphocytes receiver_anchor 0.6967533196814983 16 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells receiver_anchor 0.6692416628881765 30 +VWF-SELP|Endothelial Cells->Endothelial Cells structure_bridge 0.7854081482043567 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated structure_bridge 0.7708926279250373 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells structure_bridge 0.7055697377300002 12 +DLL4-NOTCH3|Endothelial Cells->Pericytes structure_bridge 0.6698572931376457 27 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes structure_bridge 0.7130771089942796 8 +CD48-CD2|T Lymphocytes->T Lymphocytes structure_bridge 0.6870622598572897 19 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells structure_bridge 0.6167922060783549 65 +VWF-SELP|Endothelial Cells->Endothelial Cells sender_expr 0.7854081482043567 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated sender_expr 0.7148067405584678 8 +MMRN2-CD93|Endothelial Cells->Endothelial Cells sender_expr 0.7055697377300002 9 +DLL4-NOTCH3|Endothelial Cells->Pericytes sender_expr 0.6628108709697559 33 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes sender_expr 0.6338817361079696 51 +CD48-CD2|T Lymphocytes->T Lymphocytes sender_expr 0.6870622598572897 20 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells sender_expr 0.6167922060783549 75 +VWF-SELP|Endothelial Cells->Endothelial Cells receiver_expr 0.7854081482043567 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated receiver_expr 0.7148067405584678 6 +MMRN2-CD93|Endothelial Cells->Endothelial Cells receiver_expr 0.7055697377300002 8 +DLL4-NOTCH3|Endothelial Cells->Pericytes receiver_expr 0.6787277660885117 24 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes receiver_expr 0.6338817361079696 52 +CD48-CD2|T Lymphocytes->T Lymphocytes receiver_expr 0.6870622598572897 19 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells receiver_expr 0.6167922060783549 79 +VWF-SELP|Endothelial Cells->Endothelial Cells local_contact 0.9646853087387212 16 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated local_contact 0.8530387672375239 614 +MMRN2-CD93|Endothelial Cells->Endothelial Cells local_contact 0.9696210584915509 11 +DLL4-NOTCH3|Endothelial Cells->Pericytes local_contact 0.9248792871416435 76 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes local_contact 0.8529786310985624 615 +CD48-CD2|T Lymphocytes->T Lymphocytes local_contact 0.9727447950557435 7 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells local_contact 0.8743949187647442 329 +VWF-SELP|Endothelial Cells->Endothelial Cells prior_confidence 0.7854081482043567 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated prior_confidence 0.7148067405584678 5 +MMRN2-CD93|Endothelial Cells->Endothelial Cells prior_confidence 0.7055697377300002 6 +DLL4-NOTCH3|Endothelial Cells->Pericytes prior_confidence 0.6628108709697559 20 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes prior_confidence 0.6338817361079696 29 +CD48-CD2|T Lymphocytes->T Lymphocytes prior_confidence 0.6870622598572897 13 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells prior_confidence 0.6167922060783549 41 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/contamination_controls.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/contamination_controls.tsv new file mode 100644 index 0000000..85ff31b --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/contamination_controls.tsv @@ -0,0 +1,8 @@ +axis_id contamination_marker_mean contamination_marker_detection contamination_marker_n endothelial_marker_mean endothelial_marker_detection endothelial_marker_n contamination_to_endothelial_ratio contamination_flag +VWF-SELP|Endothelial Cells->Endothelial Cells 0.05890538077801466 0.024628942486085346 5 2.5959966480731964 0.684963474025974 8 0.022690853943026265 False +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 0.026129559427499772 0.01609508256214843 5 0.717039417475462 0.20992484727514668 8 0.036440896819168185 False +MMRN2-CD93|Endothelial Cells->Endothelial Cells 0.05890538077801466 0.024628942486085346 5 2.5959966480731964 0.684963474025974 8 0.022690853943026265 False +DLL4-NOTCH3|Endothelial Cells->Pericytes 0.04168511740863323 0.01809586499910239 5 1.6176096498966217 0.4904778289749267 8 0.02576957760563387 False +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 0.01597042493522167 0.014516327788046826 5 0.060339648043736815 0.047238909426987066 8 0.2646754738053097 False +CD48-CD2|T Lymphocytes->T Lymphocytes 0.020254427567124367 0.018882514342728862 5 0.07943065511062741 0.06225056123721627 8 0.2549950965268374 False +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 0.013545505329966545 0.012730339184208883 5 0.05200395057909191 0.04524603348116684 8 0.26047069845906073 False diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/cross_method_support_detail.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/cross_method_support_detail.tsv new file mode 100644 index 0000000..ab60aa3 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/cross_method_support_detail.tsv @@ -0,0 +1,50 @@ +axis_id method exact_support same_lr_any_celltype_support same_sender_receiver_support exact_best_rank same_lr_best_rank same_lr_best_score_std artifact_path +VWF-SELP|Endothelial Cells->Endothelial Cells cellchat_conda_full True True True 805.0 805.0 0.974550519118764 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated cellchat_conda_full True True True 22.0 22.0 0.999335274753102 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +MMRN2-CD93|Endothelial Cells->Endothelial Cells cellchat_conda_full True True True 2460.0 2460.0 0.922163838946569 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +DLL4-NOTCH3|Endothelial Cells->Pericytes cellchat_conda_full True True True 4379.0 4379.0 0.86142061281337 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes cellchat_conda_full True True True 638.0 638.0 0.979836667510762 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +CD48-CD2|T Lymphocytes->T Lymphocytes cellchat_conda_full True True True 9528.0 9528.0 0.698436312990631 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cellchat_conda_full True True True 1152.0 389.0 0.987718409723981 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellchat_conda_full/cellchat_standardized.tsv +VWF-SELP|Endothelial Cells->Endothelial Cells cellphonedb True True True 692.0 692.0 0.9994161168645052 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated cellphonedb True True True 2.0 2.0 0.99999915501717 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +MMRN2-CD93|Endothelial Cells->Endothelial Cells cellphonedb True True True 1352.0 1352.0 0.9988584281967392 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +DLL4-NOTCH3|Endothelial Cells->Pericytes cellphonedb True True True 2869.0 2869.0 0.9975765892437064 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes cellphonedb True True True 171.0 171.0 0.9998563529189088 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +CD48-CD2|T Lymphocytes->T Lymphocytes cellphonedb True True True 6381.0 6381.0 0.994609009544926 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cellphonedb True True True 2782.0 1232.0 0.9989598261363328 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv +VWF-SELP|Endothelial Cells->Endothelial Cells laris True True True 2845.0 2845.0 0.9978205811017408 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated laris True True True 18.0 18.0 0.9999869725311988 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells laris True True True 5577.0 5577.0 0.99572699023323 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes laris True True True 9878.0 9878.0 0.9924310406265446 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes laris True True True 226.0 226.0 0.9998275776188086 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes laris True True True 15762.0 15762.0 0.987922003777966 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells laris True True True 2153.0 889.0 0.9993195063355648 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells liana True True True 8450.0 1616.0 0.9978299106836924 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated liana True True True 58588.0 3227.0 0.9956651962016048 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +MMRN2-CD93|Endothelial Cells->Endothelial Cells liana True True True 6324.0 3314.0 0.9955482935573206 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +DLL4-NOTCH3|Endothelial Cells->Pericytes liana True True True 81639.0 32868.0 0.955836330923168 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes liana True True True 69984.0 9542.0 0.9871796766768476 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +CD48-CD2|T Lymphocytes->T Lymphocytes liana True True True 23050.0 23050.0 0.9690288615160526 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells liana True True True 1437.0 170.0 0.9997729132542068 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv +VWF-SELP|Endothelial Cells->Endothelial Cells spatialdm True True True 1967.0 1896.0 0.9957513401775244 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatialdm True True True 13686.0 13543.0 0.9696383370364308 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatialdm True True True 5602.0 5520.0 0.9876261986489486 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes spatialdm True True True 22202.0 22100.0 0.9504532277483448 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatialdm True True True 16101.0 16018.0 0.964089295843488 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes spatialdm True True True 4354.0 4221.0 0.9905386045114264 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatialdm True True True 9527.0 9527.0 0.9786423570084952 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells squidpy True True True 316.0 316.0 0.999761291300394 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated squidpy True True True 1.0 1.0 1.0 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +MMRN2-CD93|Endothelial Cells->Endothelial Cells squidpy True True True 5514.0 5514.0 0.9958222188541982 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +DLL4-NOTCH3|Endothelial Cells->Pericytes squidpy True True True 5956.0 5956.0 0.9954872688693543 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes squidpy True True True 204.0 204.0 0.9998461655046984 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +CD48-CD2|T Lymphocytes->T Lymphocytes squidpy True True True 26974.0 26974.0 0.9795597150651713 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells squidpy True True True 12740.0 4514.0 0.9965800242497728 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/squidpy/squidpy_standardized.tsv +VWF-SELP|Endothelial Cells->Endothelial Cells stlearn True True True 82562.0 82474.0 0.8367779512785954 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated stlearn True True True 100691.0 100539.0 0.8010255679512984 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells stlearn True True True 88744.0 88651.0 0.8245530704696991 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes stlearn True True True 37015.0 36895.0 0.9269832034056298 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes stlearn True True True 47550.0 47459.0 0.9060760250236995 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes stlearn True True True 161703.0 161549.0 0.6802808734149909 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells stlearn True True True 40130.0 40130.0 0.9205808253229392 /data/taobo.hu/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/downstream_target_support.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/downstream_target_support.tsv new file mode 100644 index 0000000..312a2bc --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/downstream_target_support.tsv @@ -0,0 +1,8 @@ +axis_id downstream_status downstream_target_genes_present downstream_target_score downstream_target_null_mean downstream_target_null_sd downstream_target_z downstream_target_p downstream_target_gene_panel downstream_target_fdr +VWF-SELP|Endothelial Cells->Endothelial Cells success 6 6.738417175908883 1.0064762527795716 1.4133941349379884 4.055444112466758 0.019417475728155338 VWF,SELP,ANGPT2,THBD,PLAT,SERPINE1 0.027184466019417475 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 7 2.588202246597835 0.41110825241499005 0.5784531172302644 3.763648132120292 0.02497027348394768 VWF,LRP1,HSPG2,COL4A1,COL4A2,MMP2,THBS2 0.029131985731272295 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 7 11.116392135620117 1.047396860657526 1.5327809936425985 6.56910238104792 0.0023781212841854932 MMRN2,CD93,CLEC14A,KDR,FLT1,PECAM1,EMCN 0.008323424494649227 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 8 2.61274266988039 0.5068325942343411 0.5551530740828993 3.7933863180438414 0.014568158168574402 DLL4,NOTCH3,NOTCH4,JAG1,HEY1,HES1,PDGFRB,RGS5 0.025494276795005204 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 8 6.800970241427422 1.15657870703144 1.2287697052997264 4.59353083824538 0.012486992715920915 CXCL12,CXCR4,CXCR3,CCL19,CCL21,CD3D,CD3E,IL7R 0.025494276795005204 +CD48-CD2|T Lymphocytes->T Lymphocytes success 7 11.544674396514893 1.0685981322434686 1.2195936012363278 8.589809141054532 0.0023781212841854932 CD48,CD2,CD3D,CD3E,TRAC,IL7R,LCK 0.008323424494649227 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 7 1.5110729336738586 1.5341725096816108 0.3373003415056495 -0.06848370180901593 0.6076099881093936 JAG1,NOTCH2,NOTCH1,HES1,HEY1,MYC,CCND1 0.6076099881093936 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/expression_gene_specificity.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/expression_gene_specificity.tsv new file mode 100644 index 0000000..e50665c --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/expression_gene_specificity.tsv @@ -0,0 +1,217 @@ +gene detected_in_wta top_celltype_rank cell_type mean_expr detection_fraction +ANGPT2 True 1.0 CAFs, Invasive Associated 0.07923019245188703 0.056235939264297485 +ANGPT2 True 2.0 Pericytes 0.07468777049585755 0.05440830811858177 +ANGPT2 True 3.0 Endothelial Cells 0.06064471243042672 0.0460343211889267 +ANGPT2 True 4.0 Mast Cells 0.02710027100271003 0.027100270614027977 +ANGPT2 True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.0231519090170593 0.01909017004072666 +CCL19 True 1.0 Pericytes 0.16520341288487697 0.053171757608652115 +CCL19 True 2.0 Endothelial Cells 0.0912569573283859 0.04359925910830498 +CCL19 True 3.0 T Lymphocytes 0.08605637316038912 0.05238214135169983 +CCL19 True 4.0 Dendritic Cells 0.07784431137724551 0.04241516813635826 +CCL19 True 5.0 B Cells 0.04856687898089172 0.029458599165081978 +CCL21 True 1.0 Endothelial Cells 0.02481447124304267 0.01982838660478592 +CCL21 True 2.0 Myeloid Cells 0.02214022140221402 0.019680196419358253 +CCL21 True 3.0 Pericytes 0.017559045381476443 0.013725732453167439 +CCL21 True 4.0 Apocrine Cells 0.01488833746898263 0.014888337813317776 +CCL21 True 5.0 Plasma Cells 0.012600229095074456 0.010309278033673763 +CCND1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 45.75142160844842 0.995938241481781 +CCND1 True 2.0 11q13 Invasive Tumor Cells (G1/S) 44.573715248525694 0.9978938698768616 +CCND1 True 3.0 11q13 Invasive Tumor Cells 35.123071397339 0.991645336151123 +CCND1 True 4.0 Basal-like Structured DCIS Cells 14.588698630136987 0.928196370601654 +CCND1 True 5.0 Luminal-like Amorphous DCIS Cells 5.254068160884249 0.8043444752693176 +CD2 True 1.0 T Lymphocytes 0.49837864804190574 0.3382389545440674 +CD2 True 2.0 B Cells 0.09156050955414012 0.07762739062309265 +CD2 True 3.0 Plasma Cells 0.07331042382588775 0.05154639109969139 +CD2 True 4.0 Dendritic Cells 0.060129740518962076 0.049151696264743805 +CD2 True 5.0 Mast Cells 0.04607046070460705 0.04065040498971939 +CD3D True 1.0 T Lymphocytes 0.7599151908206535 0.42105263471603394 +CD3D True 2.0 B Cells 0.1664012738853503 0.10748407989740372 +CD3D True 3.0 Plasma Cells 0.1111111111111111 0.07445590198040009 +CD3D True 4.0 Mast Cells 0.08401084010840108 0.056910570710897446 +CD3D True 5.0 Dendritic Cells 0.08383233532934131 0.057135727256536484 +CD3E True 1.0 T Lymphocytes 1.2775006235969069 0.6097530722618103 +CD3E True 2.0 B Cells 0.2929936305732484 0.20700636506080627 +CD3E True 3.0 Plasma Cells 0.1775486827033219 0.0996563583612442 +CD3E True 4.0 Dendritic Cells 0.12250499001996008 0.08283433318138123 +CD3E True 5.0 Mast Cells 0.056910569105691054 0.046070460230112076 +CD48 True 1.0 T Lymphocytes 0.5604888999750561 0.37989524006843567 +CD48 True 2.0 Dendritic Cells 0.5446606786427146 0.33582833409309387 +CD48 True 3.0 Plasma Cells 0.3104238258877434 0.2279496043920517 +CD48 True 4.0 Mast Cells 0.20596205962059622 0.16802167892456055 +CD48 True 5.0 B Cells 0.18431528662420382 0.14331209659576416 +CD63 False +CD93 True 1.0 Endothelial Cells 0.9689239332096475 0.5012755393981934 +CD93 True 2.0 Pericytes 0.23234821318164955 0.16285395622253418 +CD93 True 3.0 Dendritic Cells 0.2315369261477046 0.16017964482307434 +CD93 True 4.0 Macrophages 0.1983941983941984 0.139860138297081 +CD93 True 5.0 Mast Cells 0.08130081300813008 0.056910570710897446 +CLEC14A True 1.0 Endothelial Cells 1.3179499072356216 0.5895176529884338 +CLEC14A True 2.0 Pericytes 0.31643378261407196 0.20934833586215973 +CLEC14A True 3.0 Myeloid Cells 0.0959409594095941 0.084870845079422 +CLEC14A True 4.0 CAFs, Invasive Associated 0.07173206698325418 0.05373656749725342 +CLEC14A True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.06498781478472786 0.058489032089710236 +COL4A1 True 1.0 Endothelial Cells 2.700139146567718 0.6525974273681641 +COL4A1 True 2.0 CAFs, Invasive Associated 2.4473881529617594 0.6213446855545044 +COL4A1 True 3.0 Pericytes 1.5722764931371336 0.5163843035697937 +COL4A1 True 4.0 CAFs, DCIS Associated 0.6216348907618034 0.3171180784702301 +COL4A1 True 5.0 Myoepithelial Cells 0.40009480919649204 0.2188907265663147 +COL4A2 True 1.0 Endothelial Cells 1.5338589981447124 0.5666744112968445 +COL4A2 True 2.0 CAFs, Invasive Associated 1.4781304673831541 0.5351161956787109 +COL4A2 True 3.0 Pericytes 1.0337578830221343 0.4361320734024048 +COL4A2 True 4.0 CAFs, DCIS Associated 0.5452499795434089 0.33074215054512024 +COL4A2 True 5.0 Myoepithelial Cells 0.5319981038160702 0.31879591941833496 +CXCL12 True 1.0 CAFs, DCIS Associated 3.649660420587513 0.7872514724731445 +CXCL12 True 2.0 CAFs, Invasive Associated 1.556610847288178 0.4851287305355072 +CXCL12 True 3.0 Endothelial Cells 1.3608534322820036 0.47993969917297363 +CXCL12 True 4.0 Macrophages 1.0893550893550894 0.40663039684295654 +CXCL12 True 5.0 Pericytes 1.0134784221590207 0.37875601649284363 +CXCR3 True 1.0 T Lymphocytes 0.034048391119980044 0.03280119597911835 +CXCR3 True 2.0 Plasma Cells 0.014891179839633447 0.014891180209815502 +CXCR3 True 3.0 Dendritic Cells 0.011477045908183632 0.010479042306542397 +CXCR3 True 4.0 Myeloid Cells 0.008610086100861008 0.008610086515545845 +CXCR3 True 5.0 Mast Cells 0.008130081300813009 0.008130080997943878 +CXCR4 True 1.0 T Lymphocytes 0.9085806934397606 0.4825392961502075 +CXCR4 True 2.0 Dendritic Cells 0.6749001996007984 0.3540419042110443 +CXCR4 True 3.0 Plasma Cells 0.36769759450171824 0.21305841207504272 +CXCR4 True 4.0 B Cells 0.21934713375796178 0.1675955355167389 +CXCR4 True 5.0 Macrophages 0.1761201761201761 0.1339031308889389 +DLL4 True 1.0 Endothelial Cells 0.476461038961039 0.2467532455921173 +DLL4 True 2.0 Pericytes 0.10634351428218128 0.07703722268342972 +DLL4 True 3.0 Myeloid Cells 0.04551045510455105 0.03198032081127167 +DLL4 True 4.0 11q13 Invasive Tumor Cells (Mitotic) 0.038180341186027617 0.03452477604150772 +DLL4 True 5.0 Plasma Cells 0.020618556701030927 0.019473081454634666 +EMCN True 1.0 Endothelial Cells 1.4728664192949907 0.6341604590415955 +EMCN True 2.0 Pericytes 0.32274020032150363 0.21491281688213348 +EMCN True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.09057676685621446 0.07514216005802155 +EMCN True 4.0 Myeloid Cells 0.06888068880688807 0.05781057849526405 +EMCN True 5.0 Plasma Cells 0.06758304696449026 0.05841924250125885 +FLT1 True 1.0 Endothelial Cells 1.5473098330241188 0.6168830990791321 +FLT1 True 2.0 Pericytes 0.3560034623469766 0.23519228398799896 +FLT1 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.24654752233956134 0.20633630454540253 +FLT1 True 4.0 Myeloid Cells 0.21648216482164823 0.16851168870925903 +FLT1 True 5.0 Apocrine Cells 0.15632754342431762 0.14640198647975922 +HES1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 0.4435418359057677 0.307879775762558 +HES1 True 2.0 Luminal-like Amorphous DCIS Cells 0.40067546822229044 0.2689591646194458 +HES1 True 3.0 11q13 Invasive Tumor Cells (G1/S) 0.33403538331929233 0.24136479198932648 +HES1 True 4.0 11q13 Invasive Tumor Cells 0.2922418639515273 0.21926729381084442 +HES1 True 5.0 Basal-like Structured DCIS Cells 0.2264840182648402 0.1742009073495865 +HEY1 True 1.0 Endothelial Cells 0.24570964749536178 0.15584415197372437 +HEY1 True 2.0 11q13 Invasive Tumor Cells (Mitotic) 0.17749796913078797 0.1486596316099167 +HEY1 True 3.0 Basal-like Structured DCIS Cells 0.1430365296803653 0.10844749212265015 +HEY1 True 4.0 Myoepithelial Cells 0.1268073003081299 0.10630480945110321 +HEY1 True 5.0 Myeloid Cells 0.10947109471094711 0.08733087033033371 +HSPG2 True 1.0 Endothelial Cells 5.104359925788497 0.8711734414100647 +HSPG2 True 2.0 CAFs, Invasive Associated 2.2671832041989504 0.6923269033432007 +HSPG2 True 3.0 Pericytes 1.1843699765055027 0.48237913846969604 +HSPG2 True 4.0 CAFs, DCIS Associated 0.8459618689141641 0.4324932396411896 +HSPG2 True 5.0 Myoepithelial Cells 0.5875799952595402 0.3209291398525238 +IL7R True 1.0 T Lymphocytes 0.20990271888251436 0.15851832926273346 +IL7R True 2.0 Myeloid Cells 0.05289052890528905 0.046740468591451645 +IL7R True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.05280259951259139 0.05158407613635063 +IL7R True 4.0 Apocrine Cells 0.04714640198511166 0.04466501250863075 +IL7R True 5.0 Dendritic Cells 0.046656686626746505 0.037425149232149124 +JAG1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 1.9065800162469537 0.7083671689033508 +JAG1 True 2.0 11q13 Invasive Tumor Cells 1.4774345680554688 0.6293959617614746 +JAG1 True 3.0 11q13 Invasive Tumor Cells (G1/S) 1.3336141533277168 0.5867733955383301 +JAG1 True 4.0 Luminal-like Amorphous DCIS Cells 1.0723825606386246 0.5086736083030701 +JAG1 True 5.0 Basal-like Structured DCIS Cells 0.6257990867579909 0.3481735289096832 +KDR True 1.0 Endothelial Cells 2.37569573283859 0.6372912526130676 +KDR True 2.0 Pericytes 0.6527760603437616 0.3185359239578247 +KDR True 3.0 CAFs, Invasive Associated 0.10547363159210198 0.06723318994045258 +KDR True 4.0 Myeloid Cells 0.09471094710947109 0.084870845079422 +KDR True 5.0 Basal-like Structured DCIS Cells 0.08367579908675798 0.06061643734574318 +LCK True 1.0 T Lymphocytes 0.6152407084060864 0.3986031413078308 +LCK True 2.0 B Cells 0.11544585987261147 0.0927547737956047 +LCK True 3.0 Plasma Cells 0.08476517754868271 0.06643757224082947 +LCK True 4.0 Myeloid Cells 0.06150061500615006 0.05166051536798477 +LCK True 5.0 Dendritic Cells 0.058632734530938126 0.04466067999601364 +LRP1 True 1.0 CAFs, Invasive Associated 2.662834291427143 0.7233191728591919 +LRP1 True 2.0 CAFs, DCIS Associated 2.585713116766222 0.7374191880226135 +LRP1 True 3.0 Dendritic Cells 1.0197105788423153 0.44386228919029236 +LRP1 True 4.0 Macrophages 0.9233359233359233 0.440559446811676 +LRP1 True 5.0 Myoepithelial Cells 0.4869637354823418 0.302085816860199 +MMP2 True 1.0 CAFs, DCIS Associated 1.4687423287783323 0.5307257771492004 +MMP2 True 2.0 CAFs, Invasive Associated 1.3129217695576105 0.4966258406639099 +MMP2 True 3.0 Endothelial Cells 0.2912801484230056 0.1832096427679062 +MMP2 True 4.0 Dendritic Cells 0.2657185628742515 0.15668663382530212 +MMP2 True 5.0 Myoepithelial Cells 0.2623844512917753 0.1821521669626236 +MMRN2 True 1.0 Endothelial Cells 1.2184601113172542 0.5637755393981934 +MMRN2 True 2.0 Pericytes 0.2594287127488562 0.17744527757167816 +MMRN2 True 3.0 Basal-like Structured DCIS Cells 0.06746575342465753 0.05319634824991226 +MMRN2 True 4.0 Myoepithelial Cells 0.06245555818914435 0.05131547898054123 +MMRN2 True 5.0 Mast Cells 0.04607046070460705 0.0379403792321682 +MYC True 1.0 Basal-like Structured DCIS Cells 1.5598173515981735 0.5699771642684937 +MYC True 2.0 Endothelial Cells 1.1174628942486085 0.4582560360431671 +MYC True 3.0 11q13 Invasive Tumor Cells (G1/S) 0.9334456613310868 0.45408591628074646 +MYC True 4.0 11q13 Invasive Tumor Cells 0.8824879755137734 0.44670185446739197 +MYC True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.8273761169780666 0.43013811111450195 +NOTCH1 True 1.0 Endothelial Cells 0.5613404452690167 0.35366418957710266 +NOTCH1 True 2.0 Basal-like Structured DCIS Cells 0.4221461187214612 0.263812780380249 +NOTCH1 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.30381803411860275 0.22542648017406464 +NOTCH1 True 4.0 Pericytes 0.22517620873006058 0.15951527655124664 +NOTCH1 True 5.0 Myoepithelial Cells 0.2188907324010429 0.15868689119815826 +NOTCH2 True 1.0 Apocrine Cells 2.1861042183622827 0.7171216011047363 +NOTCH2 True 2.0 11q13 Invasive Tumor Cells 1.3958398400899494 0.607002317905426 +NOTCH2 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 1.334281072298944 0.6255077123641968 +NOTCH2 True 4.0 Luminal-like Amorphous DCIS Cells 1.1538992938286767 0.5558028817176819 +NOTCH2 True 5.0 11q13 Invasive Tumor Cells (G1/S) 1.0602358887952823 0.5395956039428711 +NOTCH3 True 1.0 Pericytes 2.3809818226783728 0.5623840689659119 +NOTCH3 True 2.0 CAFs, Invasive Associated 1.1647088227943014 0.4973756670951843 +NOTCH3 True 3.0 Luminal-like Amorphous DCIS Cells 0.9322229045133559 0.4947804808616638 +NOTCH3 True 4.0 Endothelial Cells 0.7337662337662337 0.27516233921051025 +NOTCH3 True 5.0 Basal-like Structured DCIS Cells 0.6931506849315069 0.3960045576095581 +NOTCH4 True 1.0 Endothelial Cells 0.4457328385899815 0.28038033843040466 +NOTCH4 True 2.0 Myoepithelial Cells 0.10997866793078928 0.09042426943778992 +NOTCH4 True 3.0 Pericytes 0.08445653517991838 0.0650426596403122 +NOTCH4 True 4.0 Basal-like Structured DCIS Cells 0.07682648401826483 0.06255707889795303 +NOTCH4 True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.07636068237205523 0.06986190378665924 +PDGFRB True 1.0 CAFs, Invasive Associated 0.6135966008497875 0.3709072768688202 +PDGFRB True 2.0 Pericytes 0.42549771237789047 0.2529986500740051 +PDGFRB True 3.0 CAFs, DCIS Associated 0.32493249324932494 0.2368464171886444 +PDGFRB True 4.0 Endothelial Cells 0.15213358070500926 0.10227272659540176 +PDGFRB True 5.0 Dendritic Cells 0.05189620758483034 0.0416666679084301 +PECAM1 True 1.0 Endothelial Cells 4.5438311688311686 0.8918135166168213 +PECAM1 True 2.0 Plasma Cells 1.7445589919816724 0.6300114393234253 +PECAM1 True 3.0 Pericytes 1.0775318412266601 0.4703845679759979 +PECAM1 True 4.0 Dendritic Cells 0.7437624750499002 0.4149201512336731 +PECAM1 True 5.0 Macrophages 0.4421134421134421 0.28671327233314514 +PLAT True 1.0 11q13 Invasive Tumor Cells 8.869838840652132 0.956024706363678 +PLAT True 2.0 11q13 Invasive Tumor Cells (Mitotic) 7.280259951259139 0.9549146890640259 +PLAT True 3.0 11q13 Invasive Tumor Cells (G1/S) 6.233361415332772 0.9182813763618469 +PLAT True 4.0 Apocrine Cells 3.3101736972704714 0.8114144206047058 +PLAT True 5.0 Luminal-like Amorphous DCIS Cells 2.8183143997543754 0.6322535872459412 +RGS5 True 1.0 Pericytes 0.6418943984172129 0.3001112937927246 +RGS5 True 2.0 Endothelial Cells 0.5906771799628943 0.3025278151035309 +RGS5 True 3.0 CAFs, Invasive Associated 0.10747313171707074 0.06723318994045258 +RGS5 True 4.0 Myeloid Cells 0.07995079950799508 0.06519065052270889 +RGS5 True 5.0 Mast Cells 0.07859078590785908 0.0731707289814949 +SELP True 1.0 Endothelial Cells 0.7355055658627088 0.259508341550827 +SELP True 2.0 Pericytes 0.10980586125881044 0.07270928472280502 +SELP True 3.0 T Lymphocytes 0.06023946121227239 0.050511348992586136 +SELP True 4.0 Myeloid Cells 0.05166051660516605 0.04428044334053993 +SELP True 5.0 Plasma Cells 0.043528064146620846 0.03665521368384361 +SERPINE1 True 1.0 CAFs, Invasive Associated 0.3504123969007748 0.20569857954978943 +SERPINE1 True 2.0 Myoepithelial Cells 0.05724105238208106 0.03507940098643303 +SERPINE1 True 3.0 Endothelial Cells 0.05322356215213358 0.04012059420347214 +SERPINE1 True 4.0 CAFs, DCIS Associated 0.04107683495622289 0.03358972445130348 +SERPINE1 True 5.0 Dendritic Cells 0.036926147704590816 0.03168662637472153 +THBD True 1.0 Endothelial Cells 0.8287337662337663 0.40491652488708496 +THBD True 2.0 Pericytes 0.2860145913194015 0.18770866096019745 +THBD True 3.0 Dendritic Cells 0.1217564870259481 0.09356287121772766 +THBD True 4.0 CAFs, Invasive Associated 0.10847288177955511 0.0794801265001297 +THBD True 5.0 Myeloid Cells 0.08487084870848709 0.07503075152635574 +THBS2 True 1.0 CAFs, Invasive Associated 1.8375406148462885 0.5576105713844299 +THBS2 True 2.0 CAFs, DCIS Associated 1.6160297847966616 0.5173472166061401 +THBS2 True 3.0 Dendritic Cells 0.1317365269461078 0.071856290102005 +THBS2 True 4.0 CXCL14+ Fibroblasts 0.11588330632090761 0.07698541134595871 +THBS2 True 5.0 Pericytes 0.1151230369729195 0.07122542709112167 +TRAC True 1.0 T Lymphocytes 2.8600648540783236 0.7904714345932007 +TRAC True 2.0 B Cells 0.6871019108280255 0.3626592457294464 +TRAC True 3.0 Plasma Cells 0.33791523482245134 0.1477663218975067 +TRAC True 4.0 Dendritic Cells 0.24176646706586827 0.1230039894580841 +TRAC True 5.0 CAFs, Invasive Associated 0.15571107223194203 0.10172457247972488 +VWF True 1.0 Endothelial Cells 6.707908163265306 0.8781307935714722 +VWF True 2.0 Pericytes 1.29108445653518 0.4304439127445221 +VWF True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.11169780666125101 0.09423232823610306 +VWF True 4.0 Dendritic Cells 0.11052894211576847 0.05913173779845238 +VWF True 5.0 Mast Cells 0.10840108401084012 0.08130080997943878 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/functional_received_signal_support.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/functional_received_signal_support.tsv new file mode 100644 index 0000000..0345974 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/functional_received_signal_support.tsv @@ -0,0 +1,8 @@ +axis_id functional_signal_status received_signal_n_cells received_signal_target_spearman received_signal_target_p received_signal_top_vs_bottom_target_delta received_signal_target_fdr +VWF-SELP|Endothelial Cells->Endothelial Cells success 8624 0.6283646829850982 0.0 0.48874330520629883 0.0 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 24442 0.6575063035069829 0.0 0.5568488836288452 0.0 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 8624 0.4506380910061747 0.0 0.37315094470977783 0.0 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 8087 0.721750076253441 0.0 0.3684804439544678 0.0 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 8018 0.4955612441859473 0.0 0.19490374624729156 0.0 +CD48-CD2|T Lymphocytes->T Lymphocytes success 8018 0.4228849179250702 0.0 0.2631298005580902 0.0 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 64036 0.5874875426315861 0.0 0.44811439514160156 0.0 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/spatial_edge_summary.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/spatial_edge_summary.tsv new file mode 100644 index 0000000..0581a61 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/spatial_edge_summary.tsv @@ -0,0 +1,8 @@ +axis_id edge_count mean_distance median_distance p90_distance +VWF-SELP|Endothelial Cells->Endothelial Cells 86240 76.04301478064798 68.93717988356124 138.33223775288278 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 86240 80.87535740094346 57.15353528817341 178.660086189941 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 86240 76.04301478064798 68.93717988356124 138.33223775288278 +DLL4-NOTCH3|Endothelial Cells->Pericytes 86240 84.10916634767867 78.14056887409708 151.5374911181689 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 244420 164.7070669332812 146.09120882284316 307.8334754314995 +CD48-CD2|T Lymphocytes->T Lymphocytes 80180 61.10885372104813 33.60942094304036 154.61747704003622 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 640360 18.888647018391932 17.47750226471102 28.465688513696342 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/spatial_neighborhood_controls.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/spatial_neighborhood_controls.tsv new file mode 100644 index 0000000..a21b768 --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/spatial_neighborhood_controls.tsv @@ -0,0 +1,8 @@ +axis_id spatial_neighborhood_status spatial_edge_count spatial_edge_mean_distance spatial_lr_edge_score spatial_lr_active_edge_fraction spatial_perm_mean spatial_perm_sd spatial_perm_z spatial_perm_p spatial_matched_gene_mean spatial_matched_gene_sd spatial_matched_gene_z spatial_matched_gene_p spatial_null_fdr spatial_matched_gene_fdr +VWF-SELP|Endothelial Cells->Endothelial Cells success 86240 76.04301478064798 7.3085808753967285 0.25011595547309834 5.2657176113128665 0.04370881998253159 46.73800996916185 0.0033222591362126247 0.018927508491591045 0.027477133079608154 265.29890675949275 0.008264462809917356 0.004651162790697674 0.009641873278236915 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 86240 80.87535740094346 17.646312713623047 0.6248144712430427 16.915456352233885 0.07295353245322052 10.01810792174873 0.0033222591362126247 0.09186524196557003 0.5419791132694604 32.389527643899775 0.008264462809917356 0.004651162790697674 0.009641873278236915 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 86240 76.04301478064798 1.2517509460449219 0.29074675324675325 1.2041044370333354 0.00651539452823075 7.312912334799914 0.0033222591362126247 0.019798527385379808 0.041071614915599616 29.99522714631871 0.008264462809917356 0.004651162790697674 0.009641873278236915 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 86240 84.10916634767867 1.1946196556091309 0.14225417439703153 1.1400103183587391 0.011914708983071235 4.58335468604246 0.0033222591362126247 0.010454062237477047 0.01560259723839002 75.89541505679755 0.008264462809917356 0.004651162790697674 0.009641873278236915 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 244420 164.7070669332812 3.6240406036376953 0.3872269045086327 3.6269676375389097 0.011749306634564156 -0.24912396895010336 0.5813953488372093 0.017585406292346305 0.025217267011605142 143.01530755436883 0.008264462809917356 0.5813953488372093 0.009641873278236915 +CD48-CD2|T Lymphocytes->T Lymphocytes success 80180 61.10885372104813 0.2860439121723175 0.1294462459466201 0.27965914239486056 0.0026717226614147317 2.3897576906714106 0.009966777408637873 0.004725929109872596 0.017223321423744452 16.333550082541787 0.008264462809917356 0.011627906976744186 0.009641873278236915 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 640360 18.888647018391932 2.253023386001587 0.39369885689299766 2.055801842212677 0.0037028198352934225 53.26252763072426 0.0033222591362126247 1.8470757191379865 0.5534657573718224 0.7334648285944125 0.2066115702479339 0.004651162790697674 0.2066115702479339 diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/topolink_cci_validation_v2_evidence.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/topolink_cci_validation_v2_evidence.tsv new file mode 100644 index 0000000..86c251f --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/topolink_cci_validation_v2_evidence.tsv @@ -0,0 +1,15 @@ +axis_id biology_label ligand receptor sender receiver CCI_score pyxenium_rank sender_anchor receiver_anchor structure_bridge sender_expr receiver_expr local_contact_x prior_confidence cross_edge_count sender_expr_label receiver_expr_label ligand_sender_mean ligand_sender_detection_fraction ligand_sender_celltype_rank ligand_sender_specificity_ratio receptor_receiver_mean receptor_receiver_detection_fraction receptor_receiver_celltype_rank receptor_receiver_specificity_ratio observed_cross_edge_count expected_cross_edge_count_abundance_null cross_edge_enrichment_fold cross_edge_enrichment_z cross_edge_enrichment_p_approx local_contact_y contact_coverage within_sender_receiver_rank within_sender_receiver_n within_sender_receiver_percentile within_lr_pair_rank within_lr_pair_n within_lr_pair_percentile matched_gene_status n_controls observed_expression_specificity_score control_mean control_sd matched_gene_z matched_gene_percentile max_rank_after_ablation min_rank_after_ablation cross_method_exact_count cross_method_same_lr_count cross_method_same_sender_receiver_count supporting_methods_exact supporting_methods_same_lr target_panel_present_n receiver_context_panel_score receiver_context_panel_genes cell_label_perm_status cell_label_comm_prob cell_label_perm_mean cell_label_perm_sd cell_label_perm_z cell_label_perm_p cell_label_perm_n cell_label_perm_fdr spatial_neighborhood_status spatial_edge_count spatial_edge_mean_distance spatial_lr_edge_score spatial_lr_active_edge_fraction spatial_perm_mean spatial_perm_sd spatial_perm_z spatial_perm_p spatial_matched_gene_mean spatial_matched_gene_sd spatial_matched_gene_z spatial_matched_gene_p spatial_null_fdr spatial_matched_gene_fdr downstream_status downstream_target_genes_present downstream_target_score downstream_target_null_mean downstream_target_null_sd downstream_target_z downstream_target_p downstream_target_gene_panel downstream_target_fdr functional_signal_status received_signal_n_cells received_signal_target_spearman received_signal_target_p received_signal_top_vs_bottom_target_delta received_signal_target_fdr contamination_marker_mean contamination_marker_detection contamination_marker_n endothelial_marker_mean endothelial_marker_detection endothelial_marker_n contamination_to_endothelial_ratio contamination_flag bootstrap_rank_median bootstrap_rank_iqr bootstrap_score_mean bootstrap_score_sd bootstrap_n expression_specificity_support cell_label_permutation_support spatial_null_support matched_gene_control_support downstream_target_support functional_received_signal_support cross_method_support component_ablation_support bootstrap_stability_support support_count evidence_class interpretation_note axis_label +VWF-SELP|Endothelial Cells->Endothelial Cells WPB / endothelial activation VWF SELP Endothelial Cells Endothelial Cells 0.7854081595451057 1 0.939155377105368 0.8581763436107446 1.0 1.0 1.0 0.2912449657481761 1.0 12779 Endothelial Cells Endothelial Cells 6.707908163265306 0.8781307935714722 1 1.0 0.7355055658627088 0.259508341550827 1 1.0 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.2912449657481761 0.1111198059316065 1 3299 1.0 1 400 1.0 success 250 0.690919789894645 0.1174789121765555 0.08590980609453787 6.674917611699146 1.0 16 1 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 6 0.6656207262750022 VWF,SELP,ANGPT2,THBD,PLAT,SERPINE1 success 4.933703899383545 0.02757341218739748 0.002595310303671029 1890.383003626386 0.001996007984031936 500 0.001996007984031936 success 86240 76.04301478064798 7.3085808753967285 0.25011595547309834 5.2657176113128665 0.04370881998253159 46.73800996916185 0.0033222591362126247 0.018927508491591045 0.027477133079608154 265.29890675949275 0.008264462809917356 0.004651162790697674 0.009641873278236915 success 6 6.738417175908883 1.0064762527795716 1.4133941349379884 4.055444112466758 0.019417475728155338 VWF,SELP,ANGPT2,THBD,PLAT,SERPINE1 0.027184466019417475 success 8624 0.6283646829850982 0.0 0.48874330520629883 0.0 0.05890538077801466 0.024628942486085346 5 2.5959966480731964 0.684963474025974 8 0.022690853943026265 False 1.0 0.0 2.5247310175523965 0.011933106345753796 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "VWF-SELP +Endothelial Cells -> Endothelial Cells" +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated vascular-stromal matrix/scavenger axis VWF LRP1 Endothelial Cells CAFs, DCIS Associated 0.7148067513709494 5 0.939155377105368 0.6455155104503945 0.6355774498689515 1.0 1.0 0.3461937505325735 1.0 13942 Endothelial Cells CAFs, DCIS Associated 6.707908163265306 0.8781307935714722 1 1.0 2.585713116766222 0.7374191880226135 2 0.971037936942149 13942 9916.101448337911 1.4059961036740796 40.577088952341676 0.0 0.3461937505325735 0.1319036006311863 1 3299 1.0 1 400 1.0 success 250 0.8904867455342288 0.1132557384471686 0.06918144236447345 11.234674798948532 1.0 614 2 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 7 0.5161052675482147 VWF,LRP1,HSPG2,COL4A1,COL4A2,MMP2,THBS2 success 17.3447265625 0.2998358674645424 0.016262341095952152 1048.1203533037499 0.001996007984031936 500 0.001996007984031936 success 86240 80.87535740094346 17.646312713623047 0.6248144712430427 16.915456352233885 0.07295353245322052 10.01810792174873 0.0033222591362126247 0.09186524196557003 0.5419791132694604 32.389527643899775 0.008264462809917356 0.004651162790697674 0.009641873278236915 success 7 2.588202246597835 0.41110825241499005 0.5784531172302644 3.763648132120292 0.02497027348394768 VWF,LRP1,HSPG2,COL4A1,COL4A2,MMP2,THBS2 0.029131985731272295 success 24442 0.6575063035069829 0.0 0.5568488836288452 0.0 0.026129559427499772 0.01609508256214843 5 0.717039417475462 0.20992484727514668 8 0.036440896819168185 False 3.0 0.0 2.4760898894274397 0.003754003645322219 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "VWF-LRP1 +Endothelial Cells -> CAFs, DCIS Associated" +MMRN2-CD93|Endothelial Cells->Endothelial Cells CD93-MMRN2 angiogenesis MMRN2 CD93 Endothelial Cells Endothelial Cells 0.7055697517643245 6 0.9751523688982604 0.8521965156573951 1.0 1.0 1.0 0.1484661470807383 1.0 12779 Endothelial Cells Endothelial Cells 1.2184601113172542 0.5637755393981934 1 1.0 0.9689239332096475 0.5012755393981934 1 1.0 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.1484661470807383 0.0288754988653259 4 3299 0.9990906335253107 1 400 1.0 success 250 0.7291144166273554 0.13022764647610297 0.09662146729412627 6.198278570208171 1.0 13 6 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 7 1.0 MMRN2,CD93,CLEC14A,KDR,FLT1,PECAM1,EMCN success 1.1805951595306396 0.008823287986218929 0.0006422116967277436 1824.588180992251 0.001996007984031936 500 0.001996007984031936 success 86240 76.04301478064798 1.2517509460449219 0.29074675324675325 1.2041044370333354 0.00651539452823075 7.312912334799914 0.0033222591362126247 0.019798527385379808 0.041071614915599616 29.99522714631871 0.008264462809917356 0.004651162790697674 0.009641873278236915 success 7 11.116392135620117 1.047396860657526 1.5327809936425985 6.56910238104792 0.0023781212841854932 MMRN2,CD93,CLEC14A,KDR,FLT1,PECAM1,EMCN 0.008323424494649227 success 8624 0.4506380910061747 0.0 0.37315094470977783 0.0 0.05890538077801466 0.024628942486085346 5 2.5959966480731964 0.684963474025974 8 0.022690853943026265 False 2.0 0.0 2.48319603632674 0.009087646555426442 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "MMRN2-CD93 +Endothelial Cells -> Endothelial Cells" +CD48-CD2|T Lymphocytes->T Lymphocytes T-cell adhesion/co-stimulation CD48 CD2 T Lymphocytes T Lymphocytes 0.6870622750035398 13 0.9214912429371794 0.9193953048895664 1.0 1.0 1.0 0.1241603897223811 1.0 21212 T Lymphocytes T Lymphocytes 0.5604888999750561 0.37989524006843567 1 1.0 0.49837864804190574 0.3382389545440674 1 1.0 21212 3024.318857794739 7.0138107115687145 331.09056328473696 0.0 0.1241603897223811 0.0154158023760135 1 3299 1.0 1 400 1.0 success 250 0.5987173848132842 0.10702942070910819 0.04986335278579571 9.860708047779738 1.0 20 7 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 7 1.0 CD48,CD2,CD3D,CD3E,TRAC,IL7R,LCK success 0.2793356776237488 0.0026596546296495946 0.00022015248609680323 1256.7472114416275 0.001996007984031936 500 0.001996007984031936 success 80180 61.10885372104813 0.2860439121723175 0.1294462459466201 0.27965914239486056 0.0026717226614147317 2.3897576906714106 0.009966777408637873 0.004725929109872596 0.017223321423744452 16.333550082541787 0.008264462809917356 0.011627906976744186 0.009641873278236915 success 7 11.544674396514893 1.0685981322434686 1.2195936012363278 8.589809141054532 0.0023781212841854932 CD48,CD2,CD3D,CD3E,TRAC,IL7R,LCK 0.008323424494649227 success 8018 0.4228849179250702 0.0 0.2631298005580902 0.0 0.020254427567124367 0.018882514342728862 5 0.07943065511062741 0.06225056123721627 8 0.2549950965268374 False 5.0 0.0 1.925246611638054 0.015713655566381553 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "CD48-CD2 +T Lymphocytes -> T Lymphocytes" +DLL4-NOTCH3|Endothelial Cells->Pericytes endothelial-pericyte Notch DLL4 NOTCH3 Endothelial Cells Pericytes 0.6628108852003319 20 0.8999695474149415 0.8544260293908458 0.9385210026241833 1.0 0.8672894033034337 0.135465098207694 1.0 11379 Endothelial Cells Pericytes 0.476461038961039 0.2467532455921173 1 1.0 2.3809818226783728 0.5623840689659119 1 1.0 11379 3280.889960425034 3.4682662744732435 141.55074144031974 0.0 0.135465098207694 0.0303190087002372 1 3299 1.0 1 400 1.0 success 250 0.6103430039507179 0.10700066735274656 0.060629471265751134 8.301941713984622 1.0 76 20 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 8 0.48688694950414185 DLL4,NOTCH3,NOTCH4,JAG1,HEY1,HES1,PDGFRB,RGS5 success 1.1344451904296875 0.022496088080108164 0.0018236492093399003 609.7384829575133 0.001996007984031936 500 0.001996007984031936 success 86240 84.10916634767867 1.1946196556091309 0.14225417439703153 1.1400103183587391 0.011914708983071235 4.58335468604246 0.0033222591362126247 0.010454062237477047 0.01560259723839002 75.89541505679755 0.008264462809917356 0.004651162790697674 0.009641873278236915 success 8 2.61274266988039 0.5068325942343411 0.5551530740828993 3.7933863180438414 0.014568158168574402 DLL4,NOTCH3,NOTCH4,JAG1,HEY1,HES1,PDGFRB,RGS5 0.025494276795005204 success 8087 0.721750076253441 0.0 0.3684804439544678 0.0 0.04168511740863323 0.01809586499910239 5 1.6176096498966217 0.4904778289749267 8 0.02576957760563387 False 6.0 0.0 1.634842418466564 0.014082178981952163 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "DLL4-NOTCH3 +Endothelial Cells -> Pericytes" +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes CAF-immune chemokine recruitment CXCL12 CXCR4 CAFs, DCIS Associated T Lymphocytes 0.6338817490290192 29 0.8401391037337905 0.929067454422166 0.493435580121531 1.0 1.0 0.1684304172162009 1.0 11604 CAFs, DCIS Associated T Lymphocytes 3.649660420587513 0.7872514724731445 1 1.0 0.9085806934397606 0.4825392961502075 1 1.0 11604 9219.306750089676 1.258662968328625 24.92068208259856 2.220471678964988e-137 0.1684304172162009 0.0450706652878317 1 3299 1.0 1 400 1.0 success 250 0.7850757124806441 0.1029738649850631 0.06079893118587669 11.218977606863426 1.0 615 8 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 8 0.7664489835769633 CXCL12,CXCR4,CXCR3,CCL19,CCL21,CD3D,CD3E,IL7R success 3.3160109519958496 0.08272893443703651 0.004327497961377857 747.1481318801938 0.001996007984031936 500 0.001996007984031936 success 244420 164.7070669332812 3.6240406036376953 0.3872269045086327 3.6269676375389097 0.011749306634564156 -0.24912396895010336 0.5813953488372093 0.017585406292346305 0.025217267011605142 143.01530755436883 0.008264462809917356 0.5813953488372093 0.009641873278236915 success 8 6.800970241427422 1.15657870703144 1.2287697052997264 4.59353083824538 0.012486992715920915 CXCL12,CXCR4,CXCR3,CCL19,CCL21,CD3D,CD3E,IL7R 0.025494276795005204 success 8018 0.4955612441859473 0.0 0.19490374624729156 0.0 0.01597042493522167 0.014516327788046826 5 0.060339648043736815 0.047238909426987066 8 0.2646754738053097 False 4.0 0.0 1.9739528093875909 0.0031410030934122366 5 True True False True True True True False True 7 strong strong: 7/9 computational evidence layers support the axis; contamination_flag=False. "CXCL12-CXCR4 +CAFs, DCIS Associated -> T Lymphocytes" +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells tumor-intrinsic Notch signaling JAG1 NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6167922205938116 41 0.7293068717997298 0.6128235489150379 1.0 1.0 1.0 0.1231934200799743 1.0 423716 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 1.4774345680554688 0.6293959617614746 2 0.7749134866963281 1.3958398400899494 0.607002317905426 2 0.6385056249219633 423716 192905.1692550145 2.1964989410929725 567.2684147856648 0.0 0.1231934200799743 0.0168391092146626 8 3299 0.9978781448923917 1 400 1.0 success 250 0.6593758884575077 0.6351644259334726 0.07744275561402209 0.3126368933035661 0.576 329 30 7 7 7 cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn cellchat_conda_full,cellphonedb,laris,liana,spatialdm,squidpy,stlearn 7 0.5860530033828537 JAG1,NOTCH2,NOTCH1,HES1,HEY1,MYC,CCND1 success 2.0622618198394775 0.7131924320459366 0.005215585602508038 258.6611534368852 0.001996007984031936 500 0.001996007984031936 success 640360 18.888647018391932 2.253023386001587 0.39369885689299766 2.055801842212677 0.0037028198352934225 53.26252763072426 0.0033222591362126247 1.8470757191379865 0.5534657573718224 0.7334648285944125 0.2066115702479339 0.004651162790697674 0.2066115702479339 success 7 1.5110729336738586 1.5341725096816108 0.3373003415056495 -0.06848370180901593 0.6076099881093936 JAG1,NOTCH2,NOTCH1,HES1,HEY1,MYC,CCND1 0.6076099881093936 success 64036 0.5874875426315861 0.0 0.44811439514160156 0.0 0.013545505329966545 0.012730339184208883 5 0.05200395057909191 0.04524603348116684 8 0.26047069845906073 False 7.0 0.0 1.0246926473461682 0.0017333252101482156 5 True True True False False True True False True 6 strong strong: 6/9 computational evidence layers support the axis; contamination_flag=False. "JAG1-NOTCH2 +11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells" diff --git a/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/topolink_cci_validation_v2_false_positive_controls.tsv b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/topolink_cci_validation_v2_false_positive_controls.tsv new file mode 100644 index 0000000..5db84db --- /dev/null +++ b/benchmarking/cci_2026_atera/a100_validation_v2_collected/outputs/tables/topolink_cci_validation_v2_false_positive_controls.tsv @@ -0,0 +1,78 @@ +axis_id control_type observed expected_or_control_mean z_or_rank p_or_percentile note cell_label_comm_prob cell_label_perm_mean cell_label_perm_z cell_label_perm_p cell_label_perm_fdr spatial_lr_edge_score spatial_perm_mean spatial_perm_z spatial_perm_p spatial_null_fdr spatial_matched_gene_mean spatial_matched_gene_z spatial_matched_gene_p spatial_matched_gene_fdr downstream_target_score downstream_target_null_mean downstream_target_z downstream_target_p downstream_target_fdr received_signal_target_spearman received_signal_target_p received_signal_target_fdr received_signal_top_vs_bottom_target_delta bootstrap_rank_median bootstrap_rank_iqr bootstrap_score_mean bootstrap_score_sd +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_abundance_null 13942.0 9916.101448337911 40.577088952341676 0.0 cell-type-label abundance null for graph edge count +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 4.0 3299.0 4.0 0.9990906335253107 rank percentile against all LR pairs in the same sender-receiver cell-type pair +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_abundance_null 11379.0 3280.889960425034 141.55074144031974 0.0 cell-type-label abundance null for graph edge count +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_abundance_null 11604.0 9219.306750089676 24.92068208259856 2.220471678964988e-137 cell-type-label abundance null for graph edge count +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_abundance_null 21212.0 3024.318857794739 331.09056328473696 0.0 cell-type-label abundance null for graph edge count +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_abundance_null 423716.0 192905.1692550145 567.2684147856648 0.0 cell-type-label abundance null for graph edge count +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_sender_receiver 8.0 3299.0 8.0 0.9978781448923917 rank percentile against all LR pairs in the same sender-receiver cell-type pair +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-SELP|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.690919789894645 0.1174789121765555 6.674917611699146 1.0 matched by global mean expression and detection fraction +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated matched_gene_expression_control 0.8904867455342288 0.1132557384471686 11.234674798948532 1.0 matched by global mean expression and detection fraction +MMRN2-CD93|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.7291144166273554 0.13022764647610297 6.198278570208171 1.0 matched by global mean expression and detection fraction +DLL4-NOTCH3|Endothelial Cells->Pericytes matched_gene_expression_control 0.6103430039507179 0.10700066735274656 8.301941713984622 1.0 matched by global mean expression and detection fraction +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes matched_gene_expression_control 0.7850757124806441 0.1029738649850631 11.218977606863426 1.0 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes matched_gene_expression_control 0.5987173848132842 0.10702942070910819 9.860708047779738 1.0 matched by global mean expression and detection fraction +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells matched_gene_expression_control 0.6593758884575077 0.6351644259334726 0.3126368933035661 0.576 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes component_ablation_max_rank 20.0 7.0 20.0 worst and best rank after removing one score component +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes component_ablation_max_rank 615.0 8.0 615.0 worst and best rank after removing one score component +DLL4-NOTCH3|Endothelial Cells->Pericytes component_ablation_max_rank 76.0 20.0 76.0 worst and best rank after removing one score component +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells component_ablation_max_rank 329.0 30.0 329.0 worst and best rank after removing one score component +MMRN2-CD93|Endothelial Cells->Endothelial Cells component_ablation_max_rank 13.0 6.0 13.0 worst and best rank after removing one score component +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated component_ablation_max_rank 614.0 2.0 614.0 worst and best rank after removing one score component +VWF-SELP|Endothelial Cells->Endothelial Cells component_ablation_max_rank 16.0 1.0 16.0 worst and best rank after removing one score component +VWF-SELP|Endothelial Cells->Endothelial Cells cell_label_permutation 4.933703899383545 0.02757341218739748 1890.383003626386 0.001996007984031936 0.001996007984031936 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated cell_label_permutation 17.3447265625 0.2998358674645424 1048.1203533037499 0.001996007984031936 0.001996007984031936 +MMRN2-CD93|Endothelial Cells->Endothelial Cells cell_label_permutation 1.1805951595306396 0.008823287986218929 1824.588180992251 0.001996007984031936 0.001996007984031936 +DLL4-NOTCH3|Endothelial Cells->Pericytes cell_label_permutation 1.1344451904296875 0.022496088080108164 609.7384829575133 0.001996007984031936 0.001996007984031936 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes cell_label_permutation 3.3160109519958496 0.08272893443703651 747.1481318801938 0.001996007984031936 0.001996007984031936 +CD48-CD2|T Lymphocytes->T Lymphocytes cell_label_permutation 0.2793356776237488 0.0026596546296495946 1256.7472114416275 0.001996007984031936 0.001996007984031936 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cell_label_permutation 2.0622618198394775 0.7131924320459366 258.6611534368852 0.001996007984031936 0.001996007984031936 +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_neighborhood_permutation 7.3085808753967285 5.2657176113128665 46.73800996916185 0.0033222591362126247 0.004651162790697674 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_neighborhood_permutation 17.646312713623047 16.915456352233885 10.01810792174873 0.0033222591362126247 0.004651162790697674 +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_neighborhood_permutation 1.2517509460449219 1.2041044370333354 7.312912334799914 0.0033222591362126247 0.004651162790697674 +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_neighborhood_permutation 1.1946196556091309 1.1400103183587391 4.58335468604246 0.0033222591362126247 0.004651162790697674 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_neighborhood_permutation 3.6240406036376953 3.6269676375389097 -0.24912396895010336 0.5813953488372093 0.5813953488372093 +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_neighborhood_permutation 0.2860439121723175 0.27965914239486056 2.3897576906714106 0.009966777408637873 0.011627906976744186 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_neighborhood_permutation 2.253023386001587 2.055801842212677 53.26252763072426 0.0033222591362126247 0.004651162790697674 +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_matched_gene_pairs 7.3085808753967285 0.018927508491591045 265.29890675949275 0.008264462809917356 0.009641873278236915 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_matched_gene_pairs 17.646312713623047 0.09186524196557003 32.389527643899775 0.008264462809917356 0.009641873278236915 +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_matched_gene_pairs 1.2517509460449219 0.019798527385379808 29.99522714631871 0.008264462809917356 0.009641873278236915 +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_matched_gene_pairs 1.1946196556091309 0.010454062237477047 75.89541505679755 0.008264462809917356 0.009641873278236915 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_matched_gene_pairs 3.6240406036376953 0.017585406292346305 143.01530755436883 0.008264462809917356 0.009641873278236915 +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_matched_gene_pairs 0.2860439121723175 0.004725929109872596 16.333550082541787 0.008264462809917356 0.009641873278236915 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_matched_gene_pairs 2.253023386001587 1.8470757191379865 0.7334648285944125 0.2066115702479339 0.2066115702479339 +VWF-SELP|Endothelial Cells->Endothelial Cells downstream_target_enrichment 6.738417175908883 1.0064762527795716 4.055444112466758 0.019417475728155338 0.027184466019417475 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated downstream_target_enrichment 2.588202246597835 0.41110825241499005 3.763648132120292 0.02497027348394768 0.029131985731272295 +MMRN2-CD93|Endothelial Cells->Endothelial Cells downstream_target_enrichment 11.116392135620117 1.047396860657526 6.56910238104792 0.0023781212841854932 0.008323424494649227 +DLL4-NOTCH3|Endothelial Cells->Pericytes downstream_target_enrichment 2.61274266988039 0.5068325942343411 3.7933863180438414 0.014568158168574402 0.025494276795005204 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes downstream_target_enrichment 6.800970241427422 1.15657870703144 4.59353083824538 0.012486992715920915 0.025494276795005204 +CD48-CD2|T Lymphocytes->T Lymphocytes downstream_target_enrichment 11.544674396514893 1.0685981322434686 8.589809141054532 0.0023781212841854932 0.008323424494649227 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells downstream_target_enrichment 1.5110729336738586 1.5341725096816108 -0.06848370180901593 0.6076099881093936 0.6076099881093936 +VWF-SELP|Endothelial Cells->Endothelial Cells received_signal_target_correlation 0.6283646829850982 0.0 0.0 0.48874330520629883 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated received_signal_target_correlation 0.6575063035069829 0.0 0.0 0.5568488836288452 +MMRN2-CD93|Endothelial Cells->Endothelial Cells received_signal_target_correlation 0.4506380910061747 0.0 0.0 0.37315094470977783 +DLL4-NOTCH3|Endothelial Cells->Pericytes received_signal_target_correlation 0.721750076253441 0.0 0.0 0.3684804439544678 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes received_signal_target_correlation 0.4955612441859473 0.0 0.0 0.19490374624729156 +CD48-CD2|T Lymphocytes->T Lymphocytes received_signal_target_correlation 0.4228849179250702 0.0 0.0 0.2631298005580902 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells received_signal_target_correlation 0.5874875426315861 0.0 0.0 0.44811439514160156 +CD48-CD2|T Lymphocytes->T Lymphocytes bootstrap_stability 5.0 0.0 1.925246611638054 0.015713655566381553 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes bootstrap_stability 4.0 0.0 1.9739528093875909 0.0031410030934122366 +DLL4-NOTCH3|Endothelial Cells->Pericytes bootstrap_stability 6.0 0.0 1.634842418466564 0.014082178981952163 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells bootstrap_stability 7.0 0.0 1.0246926473461682 0.0017333252101482156 +MMRN2-CD93|Endothelial Cells->Endothelial Cells bootstrap_stability 2.0 0.0 2.48319603632674 0.009087646555426442 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated bootstrap_stability 3.0 0.0 2.4760898894274397 0.003754003645322219 +VWF-SELP|Endothelial Cells->Endothelial Cells bootstrap_stability 1.0 0.0 2.5247310175523965 0.011933106345753796 diff --git a/benchmarking/cci_2026_atera/method_manuscript/topolink_cci_method_bilingual.md b/benchmarking/cci_2026_atera/method_manuscript/topolink_cci_method_bilingual.md new file mode 100644 index 0000000..57436a5 --- /dev/null +++ b/benchmarking/cci_2026_atera/method_manuscript/topolink_cci_method_bilingual.md @@ -0,0 +1,489 @@ +# TopoLink-CCI: a topology-guided local interaction score for spatial cell-cell interaction discovery + +> **Naming update for manuscript use:** The recommended manuscript-level method name is now **TopoLink-CCI** (*Topology-guided Cell-Cell Interaction scoring*). The term **TopoLink-CCI** should be used only for the cell-cell interaction-resource mode of TopoLink-CCI, because several high-ranking axes are better described as molecular interaction or cell-cell interaction axes rather than strictly classical cell-cell interaction events. + +**Chinese name:** 拓扑引导的局部互作配体-受体评分法 +**Recommended abbreviation:** **TopoLink-CCI** +**Implementation:** `pyXenium.cci.cci_topology_analysis` + +## English Manuscript-Style Method Description + +### Title + +**TopoLink-CCI: topology-guided local interaction scoring identifies spatially supported cell-cell interaction axes in Xenium WTA data** + +### Short Title + +TopoLink-CCI for spatial cell-cell interaction discovery + +### Abstract + +Spatial cell-cell interaction analysis in imaging-based transcriptomics requires more than ligand and receptor co-expression. A candidate communication axis should also be compatible with tissue topology, sender and receiver cellular niches, local spatial contact, and prior biological plausibility. We therefore developed **TopoLink-CCI**, a topology-guided local interaction score implemented in `pyXenium`. TopoLink-CCI ranks cell-cell interaction hypotheses by integrating six evidence components: ligand-to-sender topology anchoring, receptor-to-receiver topology anchoring, sender-receiver structural bridging, sender expression support, receiver expression support, and local contact support. A curated cell-cell interaction prior can optionally modulate the final score. The resulting `CCI_score` is a discovery score rather than a standalone proof of communication; downstream validation should use expression specificity, permutation nulls, spatial nulls, matched-gene controls, cross-method consensus, downstream target support, and bootstrap stability. On the Atera Xenium WTA breast cancer dataset, TopoLink-CCI generated 1,319,600 sender-receiver cell-cell interaction hypotheses and prioritized interpretable vascular, stromal, immune, and Notch axes, including `VWF-SELP`, `VWF-LRP1`, `MMRN2-CD93`, `DLL4-NOTCH3`, `CXCL12-CXCR4`, `CD48-CD2`, and `JAG1-NOTCH2`. + +### Rationale + +Most classical cell-cell communication methods begin with the same biological premise: ligands expressed by one cell population and receptors expressed by another population may indicate intercellular signaling. Methods such as CellPhoneDB, CellChat, Squidpy, LIANA, NicheNet, stLearn, SpatialDM, COMMOT, and SpaTalk then add different layers of evidence, including curated interaction databases, expression thresholds, permutation tests, spatial proximity, downstream target response, and cross-method consensus. TopoLink-CCI follows the same cautious principle: a high score is a hypothesis generator, and orthogonal evidence is required before interpreting a candidate axis as biologically credible. + +TopoLink-CCI was designed for pyXenium analyses where a topology or structure map has already been inferred from Xenium WTA data. Instead of treating all expressed cell-cell interaction pairs equally, TopoLink-CCI asks whether the ligand is topologically anchored to the sender compartment, whether the receptor is anchored to the receiver compartment, whether the sender and receiver lie in a plausible tissue-structural relationship, whether both genes are expressed in the relevant populations, and whether local neighboring cells support the proposed contact. + +### Method Name + +We recommend naming the method **TopoLink-CCI**. + +**Full name:** Topology-guided Local Interaction Cell-Cell Interaction scoring +**Chinese full name:** 拓扑引导的局部互作配体-受体评分法 + +The name captures the three defining properties of the method: + +1. **Topo:** it uses topology-derived gene-to-cell and cell-to-cell structure information. +2. **Link:** it links ligand, receptor, sender, receiver, and local spatial contact into one hypothesis. +3. **LR:** it is designed specifically for cell-cell interaction discovery and prioritization. + +### Inputs + +TopoLink-CCI uses the following inputs: + +1. A spatial expression matrix, ideally with gene symbols as feature names. +2. Cell metadata containing a sender/receiver grouping column, typically `cell_type` or `cluster`. +3. Spatial coordinates for every cell. +4. A topology output that maps genes to cell types and cell types to tissue structures. +5. A cell-cell interaction resource containing at minimum ligand and receptor gene symbols. +6. Optional prior confidence weights for cell-cell interaction pairs. + +For the Atera Xenium WTA breast benchmark, the full dataset contained 170,057 cells, 18,028 RNA features, 20 annotated cell clusters, and a common cell-cell interaction resource of 3,299 pairs. + +### Score Components + +For a ligand \(l\), receptor \(r\), sender cell type \(s\), and receiver cell type \(t\), TopoLink-CCI computes the following components. + +#### 1. Sender Anchor + +The sender anchor measures whether the ligand is topologically close to the sender population: + +\[ +A_{\mathrm{sender}}(l,s) = 1 - D_{\mathrm{topology}}(l,s) +\] + +where \(D_{\mathrm{topology}}(l,s)\) is the topology distance or dissimilarity between ligand \(l\) and sender cell type \(s\). Higher values indicate stronger ligand-sender anchoring. + +#### 2. Receiver Anchor + +The receiver anchor measures whether the receptor is topologically close to the receiver population: + +\[ +A_{\mathrm{receiver}}(r,t) = 1 - D_{\mathrm{topology}}(r,t) +\] + +Higher values indicate stronger receptor-receiver anchoring. + +#### 3. Structure Bridge + +The structure bridge measures whether the sender and receiver compartments are compatible in the inferred tissue structure: + +\[ +B(s,t) = 1 - D_{\mathrm{structure}}(s,t) +\] + +This term favors cell-cell interaction hypotheses whose sender and receiver cell types are topologically or structurally connected. + +#### 4. Sender Expression Support + +The sender expression component measures whether ligand \(l\) is expressed in sender cell type \(s\). pyXenium uses a pseudobulk-detection support score: + +\[ +E(l,s) = \mathrm{rowNorm}\left(P(l,s)\sqrt{F(l,s)}\right) +\] + +where \(P(l,s)\) is the pseudobulk expression share of ligand \(l\) in sender \(s\), and \(F(l,s)\) is the detection fraction of ligand \(l\) in sender cells. + +#### 5. Receiver Expression Support + +The receiver expression component is computed analogously: + +\[ +E(r,t) = \mathrm{rowNorm}\left(P(r,t)\sqrt{F(r,t)}\right) +\] + +This term requires the receptor to be detected in the receiver population. + +#### 6. Local Contact Support + +The local contact component measures whether neighboring sender and receiver cells jointly express the ligand and receptor: + +\[ +C(l,r,s,t) = +\mathbb{1}_{N_{s,t} \geq N_{\min}} +\sqrt{S_{\mathrm{norm}}(l,r,s,t) \cdot Q(l,r,s,t)} +\cdot W(N_{s,t}) +\] + +where \(N_{s,t}\) is the number of local sender-receiver edges, \(N_{\min}\) is the minimum edge threshold, \(S_{\mathrm{norm}}\) is the normalized mean cell-cell interaction edge strength, \(Q\) is the active-edge coverage fraction, and \(W\) is an edge-count support term. In the current implementation, local neighborhoods are constructed by K-nearest neighbors or radius-based spatial neighborhoods. + +### Final Score + +The final score is a prior-weighted geometric mean: + +\[ +\mathrm{TopoLink\mbox{-}LR}(l,r,s,t) += +\pi(l,r) +\cdot +\mathrm{GM} +\left[ +A_{\mathrm{sender}}, +A_{\mathrm{receiver}}, +B, +E_{\mathrm{sender}}, +E_{\mathrm{receiver}}, +C +\right] +\] + +where \(\pi(l,r)\) is the optional prior confidence of the cell-cell interaction pair, and GM is the geometric mean. The geometric mean is used because a strong candidate should be supported by all major evidence components; one extremely high component should not fully compensate for missing topology, expression, or contact evidence. + +### Output + +TopoLink-CCI produces a ranked sender-receiver cell-cell interaction table. The main columns are: + +| Column | Meaning | +|---|---| +| `ligand` | Ligand gene symbol | +| `receptor` | Receptor gene symbol | +| `sender` | Sender cell type | +| `receiver` | Receiver cell type | +| `CCI_score` | TopoLink-CCI discovery score | +| `sender_anchor` | Ligand-sender topology support | +| `receiver_anchor` | Receptor-receiver topology support | +| `structure_bridge` | Sender-receiver structural support | +| `sender_expr` | Ligand expression support in sender | +| `receiver_expr` | Receptor expression support in receiver | +| `local_contact` | Spatial contact support | +| `prior_confidence` | Ligand-receptor database prior | +| `cross_edge_count` | Number of local sender-receiver edges | + +### Interpretation + +TopoLink-CCI should be interpreted as a **spatially constrained ranking method**. A high `CCI_score` indicates that the cell-cell interaction pair is simultaneously supported by topology, expression, tissue structure, and local contact. It does not prove protein secretion, receptor binding, or downstream signaling by itself. + +The most appropriate interpretation is: + +> "This cell-cell interaction axis is a high-priority spatial communication hypothesis supported by Xenium WTA topology and local tissue organization." + +### Benchmark Example + +In the Atera Xenium WTA breast cancer benchmark, TopoLink-CCI produced 1,319,600 full common-database results. The top-ranked axis was: + +| CCI pair | Sender -> Receiver | CCI_score | Interpretation | +|---|---|---:|---| +| `VWF-SELP` | Endothelial Cells -> Endothelial Cells | 0.791289 | Endothelial activation / Weibel-Palade body / vascular adhesion state | + +For this axis, the score was supported by high sender anchor, high receiver anchor, maximal structure bridge, maximal expression support, and measurable endothelial-endothelial local contact: + +| Component | Value | +|---|---:| +| `sender_anchor` | 0.955713 | +| `receiver_anchor` | 0.881913 | +| `structure_bridge` | 1.000000 | +| `sender_expr` | 1.000000 | +| `receiver_expr` | 1.000000 | +| `local_contact` | 0.291245 | +| `prior_confidence` | 1.000000 | + +### Validation Strategy + +Following the computational validation principles used in classical cell-cell interaction and cell-cell communication studies, TopoLink-CCI discoveries should be validated with orthogonal evidence layers: + +1. **Expression specificity:** ligand enriched in sender and receptor enriched in receiver. +2. **Cell-label permutation:** sender-receiver specificity exceeds randomized cell-type labels. +3. **Spatial null control:** spatial contact exceeds randomized or permuted spatial neighborhoods. +4. **Matched-gene negative controls:** the axis outperforms expression-matched random gene pairs. +5. **Downstream target support:** receiver cells show compatible target or pathway activity. +6. **Cross-method consensus:** related biology appears in CellPhoneDB, LIANA, SpatialDM, stLearn, LARIS, Squidpy, CellChat, COMMOT, SpaTalk, or other methods. +7. **Component ablation:** the score is not driven by one isolated component. +8. **Bootstrap stability:** top axes remain stable under stratified cell subsampling. + +In the current PDC clean validation run, seven biologically interpretable TopoLink-CCI axes were classified as having strong computational support: `VWF-SELP`, `VWF-LRP1`, `MMRN2-CD93`, `CD48-CD2`, `DLL4-NOTCH3`, `CXCL12-CXCR4`, and `JAG1-NOTCH2`. + +### Strengths + +TopoLink-CCI has several practical advantages for Xenium WTA data: + +1. It explicitly uses spatial topology rather than only pseudobulk expression. +2. It penalizes cell-cell interaction hypotheses lacking local cell-cell contact. +3. It keeps component-level diagnostics, making biological interpretation transparent. +4. It works naturally with pyXenium topology, contour, pathway, and mechanostress analyses. +5. It can be benchmarked against both spatial and non-spatial CCI methods through a common standardized output schema. + +### Limitations + +TopoLink-CCI has important limitations: + +1. RNA co-localization does not prove protein-level ligand secretion or receptor binding. +2. A high score may reflect a shared cellular state, especially for autocrine or same-cell-type axes. +3. The method depends on the quality of cell-type annotation and topology inference. +4. Genes with very strong cell-type specificity may score highly and still require null controls. +5. Prior database quality affects which cell-cell interaction pairs are tested. +6. Downstream functional validation remains necessary for causal claims. + +### Recommended Reporting Language + +For manuscripts, we recommend the following language: + +> "We used TopoLink-CCI, a topology-guided local interaction score implemented in pyXenium, to prioritize spatial cell-cell interaction hypotheses. TopoLink-CCI integrates ligand-sender topology anchoring, receptor-receiver topology anchoring, sender-receiver structural bridging, sender and receiver expression support, and local spatial contact. Candidate axes were then evaluated using expression specificity, permutation nulls, spatial controls, matched-gene negative controls, cross-method consensus, downstream target support, ablation analysis, and bootstrap stability. We therefore interpret high-scoring axes as computationally supported spatial communication hypotheses rather than direct proof of protein-level signaling." + +### References + +1. Efremova M, et al. CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit cell-cell interaction complexes. *Nature Protocols*. 2020. https://www.nature.com/articles/s41596-020-0292-x +2. Jin S, et al. Inference and analysis of cell-cell communication using CellChat. *Nature Communications*. 2021. https://www.nature.com/articles/s41467-021-21246-9 +3. Browaeys R, et al. NicheNet: modeling intercellular communication by linking ligands to target genes. *Nature Methods*. 2020. https://www.nature.com/articles/s41592-019-0667-5 +4. Dimitrov D, et al. Comparison of methods and resources for cell-cell communication inference from single-cell RNA-seq data. *Nature Communications*. 2022. https://www.nature.com/articles/s41467-022-30755-0 +5. Palla G, et al. Squidpy: a scalable framework for spatial omics analysis. *Nature Methods*. 2022. https://www.nature.com/articles/s41592-021-01358-2 +6. Pham D, et al. stLearn: integrating spatial location, tissue morphology and gene expression to find cell-cell interactions. *Nature Communications*. 2023. https://www.nature.com/articles/s41467-023-43120-6 +7. Li H, et al. SpatialDM for spatially resolved transcriptomics cell-cell interaction inference. *Nature Communications*. 2023. https://www.nature.com/articles/s41467-023-39608-w +8. Cang Z, et al. Screening cell-cell communication in spatial transcriptomics via collective optimal transport. *Nature Methods*. 2023. https://www.nature.com/articles/s41592-022-01728-4 +9. Shao X, et al. SpaTalk: inferring spatially resolved cell-cell communication. *Nature Communications*. 2022. https://www.nature.com/articles/s41467-022-32111-8 + +--- + +# TopoLink-CCI：用于空间配体-受体发现的拓扑引导局部互作评分法 + +**英文名称：** Topology-guided Local Interaction Cell-Cell Interaction scoring +**推荐缩写：** **TopoLink-CCI** +**实现函数：** `pyXenium.cci.cci_topology_analysis` + +## 中文论文式方法说明 + +### 标题 + +**TopoLink-CCI：一种用于 Xenium WTA 空间配体-受体发现的拓扑引导局部互作评分方法** + +### 短标题 + +TopoLink-CCI 空间配体-受体分析 + +### 摘要 + +在基于成像的空间转录组数据中，配体-受体分析不能只依赖配体和受体是否表达。一个可信的细胞通讯候选轴还应当同时满足组织拓扑合理性、sender 和 receiver 细胞生态位匹配、局部空间接触支持以及已有配体-受体知识库的生物学先验。为此，我们在 pyXenium 中开发了 **TopoLink-CCI**，即拓扑引导的局部互作配体-受体评分法。TopoLink-CCI 综合六类证据：配体与 sender 的拓扑锚定、受体与 receiver 的拓扑锚定、sender-receiver 结构桥接、sender 表达支持、receiver 表达支持以及局部空间接触支持，并可进一步引入配体-受体数据库先验。TopoLink-CCI 的 `CCI_score` 是候选发现评分，而不是单独证明细胞通讯真实存在的证据。因此，高分候选轴需要进一步通过表达特异性、置换检验、空间 null、表达匹配随机基因对、跨方法一致性、下游靶基因支持和重采样稳定性进行验证。在 Atera Xenium WTA 乳腺癌数据中，TopoLink-CCI 生成了 1,319,600 条 sender-receiver 配体-受体假设，并优先发现了具有明确生物学解释的血管、基质、免疫和 Notch 相关轴，例如 `VWF-SELP`、`VWF-LRP1`、`MMRN2-CD93`、`DLL4-NOTCH3`、`CXCL12-CXCR4`、`CD48-CD2` 和 `JAG1-NOTCH2`。 + +### 方法动机 + +经典细胞通讯方法通常从同一个生物学假设出发：如果一个细胞群表达配体，另一个细胞群表达相应受体，那么二者之间可能存在细胞间通讯。CellPhoneDB、CellChat、Squidpy、LIANA、NicheNet、stLearn、SpatialDM、COMMOT 和 SpaTalk 等方法会在这个基础上叠加不同的证据层，例如配体-受体知识库、表达阈值、置换检验、空间邻近性、下游靶基因响应和多方法一致性。TopoLink-CCI 采用同样谨慎的思想：高分结果首先是一个候选发现，真正的生物学解释需要独立证据支持。 + +TopoLink-CCI 面向已经完成 pyXenium 拓扑分析的 Xenium WTA 数据。它不仅判断配体和受体是否表达，还进一步询问：配体是否拓扑上锚定到 sender 细胞类型，受体是否拓扑上锚定到 receiver 细胞类型，sender 和 receiver 是否具有合理的组织结构关系，两者是否在局部空间邻域中实际相邻，以及局部邻接细胞是否共同支持该配体-受体轴。 + +### 方法命名 + +推荐方法名称为 **TopoLink-CCI**。 + +**英文全称：** Topology-guided Local Interaction Cell-Cell Interaction scoring +**中文全称：** 拓扑引导的局部互作配体-受体评分法 + +这个名称概括了方法的三个核心特征： + +1. **Topo：** 方法使用基因-细胞类型和细胞类型-组织结构的拓扑信息。 +2. **Link：** 方法把配体、受体、sender、receiver 和局部空间接触连接成一个完整假设。 +3. **LR：** 方法专门用于 cell-cell interaction 候选轴发现和排序。 + +### 输入数据 + +TopoLink-CCI 需要以下输入： + +1. 空间表达矩阵，推荐使用 gene symbol 作为特征名。 +2. 细胞元数据，其中包含 sender/receiver 分组列，例如 `cell_type` 或 `cluster`。 +3. 每个细胞的空间坐标。 +4. pyXenium 拓扑分析结果，包括基因到细胞类型、细胞类型到组织结构的映射。 +5. 配体-受体数据库，至少包含 ligand 和 receptor 基因名。 +6. 可选的配体-受体先验置信度。 + +在 Atera Xenium WTA 乳腺癌 benchmark 中，完整数据包含 170,057 个细胞、18,028 个 RNA features、20 个细胞簇，以及 3,299 对 common cell-cell interaction pairs。 + +### 评分组件 + +对于配体 \(l\)、受体 \(r\)、sender 细胞类型 \(s\) 和 receiver 细胞类型 \(t\)，TopoLink-CCI 计算以下六个组件。 + +#### 1. Sender Anchor + +sender anchor 衡量配体是否在拓扑上贴近 sender 细胞群： + +\[ +A_{\mathrm{sender}}(l,s) = 1 - D_{\mathrm{topology}}(l,s) +\] + +其中 \(D_{\mathrm{topology}}(l,s)\) 表示配体 \(l\) 与 sender 细胞类型 \(s\) 之间的拓扑距离或不相似度。数值越高，说明配体越锚定到 sender。 + +#### 2. Receiver Anchor + +receiver anchor 衡量受体是否在拓扑上贴近 receiver 细胞群： + +\[ +A_{\mathrm{receiver}}(r,t) = 1 - D_{\mathrm{topology}}(r,t) +\] + +数值越高，说明受体越锚定到 receiver。 + +#### 3. Structure Bridge + +structure bridge 衡量 sender 和 receiver 在组织结构中是否存在合理连接： + +\[ +B(s,t) = 1 - D_{\mathrm{structure}}(s,t) +\] + +该项提高那些发生在结构上相邻、相连或组织生态位上相关的 sender-receiver 组合的得分。 + +#### 4. Sender Expression Support + +sender expression support 衡量配体 \(l\) 是否在 sender 细胞群 \(s\) 中表达。pyXenium 使用 pseudobulk-detection 组合评分： + +\[ +E(l,s) = \mathrm{rowNorm}\left(P(l,s)\sqrt{F(l,s)}\right) +\] + +其中 \(P(l,s)\) 是配体 \(l\) 在 sender \(s\) 中的 pseudobulk 表达份额，\(F(l,s)\) 是 sender 细胞中检测到该配体的细胞比例。 + +#### 5. Receiver Expression Support + +receiver expression support 以同样方式计算： + +\[ +E(r,t) = \mathrm{rowNorm}\left(P(r,t)\sqrt{F(r,t)}\right) +\] + +该项要求受体在 receiver 细胞群中有表达支持。 + +#### 6. Local Contact Support + +local contact support 衡量局部相邻的 sender 和 receiver 细胞是否共同表达该配体-受体组合： + +\[ +C(l,r,s,t) = +\mathbb{1}_{N_{s,t} \geq N_{\min}} +\sqrt{S_{\mathrm{norm}}(l,r,s,t) \cdot Q(l,r,s,t)} +\cdot W(N_{s,t}) +\] + +其中 \(N_{s,t}\) 是 sender-receiver 局部边数量，\(N_{\min}\) 是最小边数阈值，\(S_{\mathrm{norm}}\) 是标准化后的局部边表达强度，\(Q\) 是活跃边覆盖比例，\(W\) 是边数支持项。当前实现可使用 K 近邻或半径邻域构建局部空间图。 + +### 最终得分 + +最终得分为先验加权的几何平均： + +\[ +\mathrm{TopoLink\mbox{-}LR}(l,r,s,t) += +\pi(l,r) +\cdot +\mathrm{GM} +\left[ +A_{\mathrm{sender}}, +A_{\mathrm{receiver}}, +B, +E_{\mathrm{sender}}, +E_{\mathrm{receiver}}, +C +\right] +\] + +其中 \(\pi(l,r)\) 是配体-受体先验置信度，GM 为几何平均。使用几何平均的原因是：一个可信的 LR 轴应当同时得到多个证据组件支持；某一个组件极高不应完全补偿拓扑、表达或局部接触证据的缺失。 + +### 输出结果 + +TopoLink-CCI 输出一个按 sender-receiver 配体-受体候选轴排序的表格。主要列包括： + +| 列名 | 含义 | +|---|---| +| `ligand` | 配体基因名 | +| `receptor` | 受体基因名 | +| `sender` | sender 细胞类型 | +| `receiver` | receiver 细胞类型 | +| `CCI_score` | TopoLink-CCI 发现评分 | +| `sender_anchor` | 配体-sender 拓扑支持 | +| `receiver_anchor` | 受体-receiver 拓扑支持 | +| `structure_bridge` | sender-receiver 结构支持 | +| `sender_expr` | sender 中配体表达支持 | +| `receiver_expr` | receiver 中受体表达支持 | +| `local_contact` | 局部空间接触支持 | +| `prior_confidence` | 配体-受体数据库先验 | +| `cross_edge_count` | 局部 sender-receiver 边数量 | + +### 结果解释 + +TopoLink-CCI 应被理解为一种 **空间约束的候选排序方法**。高 `CCI_score` 表示该配体-受体轴同时获得拓扑、表达、组织结构和局部接触支持，但它本身不能证明蛋白分泌、受体结合或下游信号激活。 + +推荐的解释方式是： + +> "该配体-受体轴是一个由 Xenium WTA 拓扑和局部组织结构支持的高优先级空间细胞通讯候选假设。" + +### Benchmark 示例 + +在 Atera Xenium WTA 乳腺癌 benchmark 中，TopoLink-CCI 生成了 1,319,600 条 full common-database 结果。排名第一的轴为： + +| CCI pair | Sender -> Receiver | CCI_score | 生物学解释 | +|---|---|---:|---| +| `VWF-SELP` | Endothelial Cells -> Endothelial Cells | 0.791289 | 内皮激活 / Weibel-Palade body / 血管黏附状态 | + +该轴同时具有较高的 sender anchor、receiver anchor、structure bridge、表达支持和可测量的 endothelial-endothelial 局部接触： + +| 组件 | 数值 | +|---|---:| +| `sender_anchor` | 0.955713 | +| `receiver_anchor` | 0.881913 | +| `structure_bridge` | 1.000000 | +| `sender_expr` | 1.000000 | +| `receiver_expr` | 1.000000 | +| `local_contact` | 0.291245 | +| `prior_confidence` | 1.000000 | + +### 验证策略 + +参考经典 LR/CCC 方法论文中的计算型防假阳性思想，TopoLink-CCI 发现需要通过以下独立证据层验证： + +1. **表达特异性：** 配体在 sender 中富集，受体在 receiver 中富集。 +2. **细胞标签置换：** 真实 sender-receiver 特异性高于随机 cell-type label。 +3. **空间 null：** 真实局部接触高于随机或置换后的空间邻域。 +4. **表达匹配随机基因对：** 真实 LR 轴优于表达水平相近的随机 gene pairs。 +5. **下游靶基因支持：** receiver 细胞具有兼容的靶基因或通路活性。 +6. **跨方法一致性：** 相关生物学主题可被 CellPhoneDB、LIANA、SpatialDM、stLearn、LARIS、Squidpy、CellChat、COMMOT、SpaTalk 或其他方法支持。 +7. **组件消融：** 高分结果不是由单一组件人为推高。 +8. **重采样稳定性：** 在分层 bootstrap 子采样中，高分轴排名稳定。 + +在当前 PDC clean validation run 中，七条具有明确生物学解释的 TopoLink-CCI 轴被评为 strong computational support：`VWF-SELP`、`VWF-LRP1`、`MMRN2-CD93`、`CD48-CD2`、`DLL4-NOTCH3`、`CXCL12-CXCR4` 和 `JAG1-NOTCH2`。 + +### 方法优势 + +TopoLink-CCI 对 Xenium WTA 数据具有以下优势： + +1. 显式利用空间拓扑，而不仅仅依赖 pseudobulk 表达。 +2. 对缺乏局部细胞接触的 LR 假设进行惩罚。 +3. 保留组件级诊断，使生物学解释更加透明。 +4. 能自然结合 pyXenium 的 topology、contour、pathway 和 mechanostress 分析。 +5. 可通过统一输出 schema 与空间和非空间 LR 方法进行 benchmark。 + +### 局限性 + +TopoLink-CCI 也有重要局限： + +1. RNA 共定位不能证明蛋白水平分泌、受体结合或功能激活。 +2. 高分同细胞类型轴可能反映共享细胞状态，而不一定是经典旁分泌信号。 +3. 方法依赖细胞类型注释和拓扑推断质量。 +4. 细胞类型特异性极强的高表达基因可能得到高分，因此仍需 null controls。 +5. 配体-受体数据库质量会影响候选集合。 +6. 若要提出因果机制，仍需要功能实验或蛋白层验证。 + +### 论文推荐表述 + +建议在论文中这样描述： + +> "我们使用 TopoLink-CCI，一种在 pyXenium 中实现的拓扑引导局部互作评分方法，对空间配体-受体候选轴进行排序。TopoLink-CCI 综合配体-sender 拓扑锚定、受体-receiver 拓扑锚定、sender-receiver 结构桥接、sender 和 receiver 表达支持以及局部空间接触。随后，我们使用表达特异性、置换 null、空间 controls、表达匹配随机基因对、跨方法一致性、下游靶基因支持、组件消融和 bootstrap 稳定性对候选轴进行验证。因此，我们将高分轴解释为具有计算证据支持的空间细胞通讯假设，而不是蛋白水平信号传递的直接证明。" + +### 参考文献 + +1. Efremova M, et al. CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit cell-cell interaction complexes. *Nature Protocols*. 2020. https://www.nature.com/articles/s41596-020-0292-x +2. Jin S, et al. Inference and analysis of cell-cell communication using CellChat. *Nature Communications*. 2021. https://www.nature.com/articles/s41467-021-21246-9 +3. Browaeys R, et al. NicheNet: modeling intercellular communication by linking ligands to target genes. *Nature Methods*. 2020. https://www.nature.com/articles/s41592-019-0667-5 +4. Dimitrov D, et al. Comparison of methods and resources for cell-cell communication inference from single-cell RNA-seq data. *Nature Communications*. 2022. https://www.nature.com/articles/s41467-022-30755-0 +5. Palla G, et al. Squidpy: a scalable framework for spatial omics analysis. *Nature Methods*. 2022. https://www.nature.com/articles/s41592-021-01358-2 +6. Pham D, et al. stLearn: integrating spatial location, tissue morphology and gene expression to find cell-cell interactions. *Nature Communications*. 2023. https://www.nature.com/articles/s41467-023-43120-6 +7. Li H, et al. SpatialDM for spatially resolved transcriptomics cell-cell interaction inference. *Nature Communications*. 2023. https://www.nature.com/articles/s41467-023-39608-w +8. Cang Z, et al. Screening cell-cell communication in spatial transcriptomics via collective optimal transport. *Nature Methods*. 2023. https://www.nature.com/articles/s41592-022-01728-4 +9. Shao X, et al. 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"/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_false_positive_controls_shared/tables/topolink_cci_validation_evidence.tsv", + "controls": "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_false_positive_controls_shared/tables/topolink_cci_false_positive_controls.tsv", + "scoreboard": "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_false_positive_controls_shared/topolink_cci_validation_scoreboard.md", + "figure": "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_false_positive_controls_shared/figures/topolink_cci_validation_figure.png" + } +} \ No newline at end of file diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_component_ablation.tsv b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_component_ablation.tsv new file mode 100644 index 0000000..3f55128 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_component_ablation.tsv @@ -0,0 +1,50 @@ +axis_id removed_component score_without_component rank_without_component +VWF-SELP|Endothelial Cells->Endothelial Cells sender_anchor 0.7972857392911651 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated sender_anchor 0.7536441590057466 4 +MMRN2-CD93|Endothelial Cells->Endothelial Cells sender_anchor 0.7125678529202889 14 +DLL4-NOTCH3|Endothelial Cells->Pericytes sender_anchor 0.6790747556139168 28 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes sender_anchor 0.6743531931310739 33 +CD48-CD2|T Lymphocytes->T Lymphocytes sender_anchor 0.6935160950384847 20 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells sender_anchor 0.6587434848395158 43 +VWF-SELP|Endothelial Cells->Endothelial Cells receiver_anchor 0.8080365281394246 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated receiver_anchor 0.7874256371615272 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells receiver_anchor 0.7257852420645114 10 +DLL4-NOTCH3|Endothelial Cells->Pericytes receiver_anchor 0.6836951692860163 27 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes receiver_anchor 0.6733001253395631 37 +CD48-CD2|T Lymphocytes->T Lymphocytes receiver_anchor 0.6976271933807175 20 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells receiver_anchor 0.6788097405077063 32 +VWF-SELP|Endothelial Cells->Endothelial Cells structure_bridge 0.7912892254406051 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated structure_bridge 0.7899855906874971 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells structure_bridge 0.710716588607183 16 +DLL4-NOTCH3|Endothelial Cells->Pericytes structure_bridge 0.6756766094906939 28 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes structure_bridge 0.7165895274301202 11 +CD48-CD2|T Lymphocytes->T Lymphocytes structure_bridge 0.6849876914223857 24 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells structure_bridge 0.6339180916556525 64 +VWF-SELP|Endothelial Cells->Endothelial Cells sender_expr 0.7912892254406051 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated sender_expr 0.7479758804762829 4 +MMRN2-CD93|Endothelial Cells->Endothelial Cells sender_expr 0.710716588607183 15 +DLL4-NOTCH3|Endothelial Cells->Pericytes sender_expr 0.6695148328230778 40 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes sender_expr 0.6616803560938078 46 +CD48-CD2|T Lymphocytes->T Lymphocytes sender_expr 0.6849876914223857 27 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells sender_expr 0.6339180916556525 74 +VWF-SELP|Endothelial Cells->Endothelial Cells receiver_expr 0.7912892254406051 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated receiver_expr 0.7479758804762829 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells receiver_expr 0.710716588607183 12 +DLL4-NOTCH3|Endothelial Cells->Pericytes receiver_expr 0.6855927184481351 25 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes receiver_expr 0.6616803560938078 47 +CD48-CD2|T Lymphocytes->T Lymphocytes receiver_expr 0.6849876914223857 26 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells receiver_expr 0.6339180916556525 82 +VWF-SELP|Endothelial Cells->Endothelial Cells local_contact 0.9719087998908531 13 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated local_contact 0.8926222806830125 566 +MMRN2-CD93|Endothelial Cells->Endothelial Cells local_contact 0.9766940588323647 9 +DLL4-NOTCH3|Endothelial Cells->Pericytes local_contact 0.9342339246883292 86 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes local_contact 0.890385654319548 708 +CD48-CD2|T Lymphocytes->T Lymphocytes local_contact 0.9698076148830775 16 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells local_contact 0.8986734151214785 387 +VWF-SELP|Endothelial Cells->Endothelial Cells prior_confidence 0.7912892254406051 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated prior_confidence 0.7479758804762829 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells prior_confidence 0.710716588607183 10 +DLL4-NOTCH3|Endothelial Cells->Pericytes prior_confidence 0.6695148328230778 24 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes prior_confidence 0.6616803560938078 28 +CD48-CD2|T Lymphocytes->T Lymphocytes prior_confidence 0.6849876914223857 16 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells prior_confidence 0.6339180916556525 45 diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_cross_method_support_detail.tsv b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_cross_method_support_detail.tsv 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/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes cellphonedb True True True 2869.0 2869.0 0.9975765892437064 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes cellphonedb True True True 171.0 171.0 0.9998563529189088 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes cellphonedb True True True 6381.0 6381.0 0.994609009544926 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cellphonedb True True True 2782.0 1232.0 0.9989598261363328 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells laris True True True 2845.0 2845.0 0.9978205811017408 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated laris True True True 18.0 18.0 0.9999869725311988 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells laris True True True 5577.0 5577.0 0.99572699023323 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes laris True True True 9878.0 9878.0 0.9924310406265446 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes laris True True True 226.0 226.0 0.9998275776188086 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes laris True True True 15762.0 15762.0 0.987922003777966 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells laris True True True 2153.0 889.0 0.9993195063355648 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells liana True True True 8450.0 1616.0 0.9978299106836924 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated liana True True True 58588.0 3227.0 0.9956651962016048 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells liana True True True 6324.0 3314.0 0.9955482935573206 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes liana True True True 81639.0 32868.0 0.955836330923168 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes liana True True True 69984.0 9542.0 0.9871796766768476 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes liana True True True 23050.0 23050.0 0.9690288615160526 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor 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/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatialdm True True True 16101.0 16018.0 0.964089295843488 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes spatialdm True True True 4354.0 4221.0 0.9905386045114264 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatialdm True True True 9527.0 9527.0 0.9786423570084952 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells stlearn True True True 86660.0 86572.0 0.8286676126749274 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated stlearn True True True 111879.0 111727.0 0.7788834331787658 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells stlearn True True True 114076.0 113983.0 0.7744185908435108 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes stlearn True True True 39734.0 39614.0 0.921602039261322 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes stlearn True True True 40249.0 40158.0 0.9205254106131044 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes stlearn True True True 181555.0 181401.0 0.6409918441421705 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells stlearn True True True 36606.0 36606.0 0.9275551623749954 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_expression_gene_specificity.tsv b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_expression_gene_specificity.tsv new file mode 100644 index 0000000..e50665c --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_expression_gene_specificity.tsv @@ -0,0 +1,217 @@ +gene detected_in_wta top_celltype_rank cell_type mean_expr detection_fraction +ANGPT2 True 1.0 CAFs, Invasive Associated 0.07923019245188703 0.056235939264297485 +ANGPT2 True 2.0 Pericytes 0.07468777049585755 0.05440830811858177 +ANGPT2 True 3.0 Endothelial Cells 0.06064471243042672 0.0460343211889267 +ANGPT2 True 4.0 Mast Cells 0.02710027100271003 0.027100270614027977 +ANGPT2 True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.0231519090170593 0.01909017004072666 +CCL19 True 1.0 Pericytes 0.16520341288487697 0.053171757608652115 +CCL19 True 2.0 Endothelial Cells 0.0912569573283859 0.04359925910830498 +CCL19 True 3.0 T Lymphocytes 0.08605637316038912 0.05238214135169983 +CCL19 True 4.0 Dendritic Cells 0.07784431137724551 0.04241516813635826 +CCL19 True 5.0 B Cells 0.04856687898089172 0.029458599165081978 +CCL21 True 1.0 Endothelial Cells 0.02481447124304267 0.01982838660478592 +CCL21 True 2.0 Myeloid Cells 0.02214022140221402 0.019680196419358253 +CCL21 True 3.0 Pericytes 0.017559045381476443 0.013725732453167439 +CCL21 True 4.0 Apocrine Cells 0.01488833746898263 0.014888337813317776 +CCL21 True 5.0 Plasma Cells 0.012600229095074456 0.010309278033673763 +CCND1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 45.75142160844842 0.995938241481781 +CCND1 True 2.0 11q13 Invasive Tumor Cells (G1/S) 44.573715248525694 0.9978938698768616 +CCND1 True 3.0 11q13 Invasive Tumor Cells 35.123071397339 0.991645336151123 +CCND1 True 4.0 Basal-like Structured DCIS Cells 14.588698630136987 0.928196370601654 +CCND1 True 5.0 Luminal-like Amorphous DCIS Cells 5.254068160884249 0.8043444752693176 +CD2 True 1.0 T Lymphocytes 0.49837864804190574 0.3382389545440674 +CD2 True 2.0 B Cells 0.09156050955414012 0.07762739062309265 +CD2 True 3.0 Plasma Cells 0.07331042382588775 0.05154639109969139 +CD2 True 4.0 Dendritic Cells 0.060129740518962076 0.049151696264743805 +CD2 True 5.0 Mast Cells 0.04607046070460705 0.04065040498971939 +CD3D True 1.0 T Lymphocytes 0.7599151908206535 0.42105263471603394 +CD3D True 2.0 B Cells 0.1664012738853503 0.10748407989740372 +CD3D True 3.0 Plasma Cells 0.1111111111111111 0.07445590198040009 +CD3D True 4.0 Mast Cells 0.08401084010840108 0.056910570710897446 +CD3D True 5.0 Dendritic Cells 0.08383233532934131 0.057135727256536484 +CD3E True 1.0 T Lymphocytes 1.2775006235969069 0.6097530722618103 +CD3E True 2.0 B Cells 0.2929936305732484 0.20700636506080627 +CD3E True 3.0 Plasma Cells 0.1775486827033219 0.0996563583612442 +CD3E True 4.0 Dendritic Cells 0.12250499001996008 0.08283433318138123 +CD3E True 5.0 Mast Cells 0.056910569105691054 0.046070460230112076 +CD48 True 1.0 T Lymphocytes 0.5604888999750561 0.37989524006843567 +CD48 True 2.0 Dendritic Cells 0.5446606786427146 0.33582833409309387 +CD48 True 3.0 Plasma Cells 0.3104238258877434 0.2279496043920517 +CD48 True 4.0 Mast Cells 0.20596205962059622 0.16802167892456055 +CD48 True 5.0 B Cells 0.18431528662420382 0.14331209659576416 +CD63 False +CD93 True 1.0 Endothelial Cells 0.9689239332096475 0.5012755393981934 +CD93 True 2.0 Pericytes 0.23234821318164955 0.16285395622253418 +CD93 True 3.0 Dendritic Cells 0.2315369261477046 0.16017964482307434 +CD93 True 4.0 Macrophages 0.1983941983941984 0.139860138297081 +CD93 True 5.0 Mast Cells 0.08130081300813008 0.056910570710897446 +CLEC14A True 1.0 Endothelial Cells 1.3179499072356216 0.5895176529884338 +CLEC14A True 2.0 Pericytes 0.31643378261407196 0.20934833586215973 +CLEC14A True 3.0 Myeloid Cells 0.0959409594095941 0.084870845079422 +CLEC14A True 4.0 CAFs, Invasive Associated 0.07173206698325418 0.05373656749725342 +CLEC14A True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.06498781478472786 0.058489032089710236 +COL4A1 True 1.0 Endothelial Cells 2.700139146567718 0.6525974273681641 +COL4A1 True 2.0 CAFs, Invasive Associated 2.4473881529617594 0.6213446855545044 +COL4A1 True 3.0 Pericytes 1.5722764931371336 0.5163843035697937 +COL4A1 True 4.0 CAFs, DCIS Associated 0.6216348907618034 0.3171180784702301 +COL4A1 True 5.0 Myoepithelial Cells 0.40009480919649204 0.2188907265663147 +COL4A2 True 1.0 Endothelial Cells 1.5338589981447124 0.5666744112968445 +COL4A2 True 2.0 CAFs, Invasive Associated 1.4781304673831541 0.5351161956787109 +COL4A2 True 3.0 Pericytes 1.0337578830221343 0.4361320734024048 +COL4A2 True 4.0 CAFs, DCIS Associated 0.5452499795434089 0.33074215054512024 +COL4A2 True 5.0 Myoepithelial Cells 0.5319981038160702 0.31879591941833496 +CXCL12 True 1.0 CAFs, DCIS Associated 3.649660420587513 0.7872514724731445 +CXCL12 True 2.0 CAFs, Invasive Associated 1.556610847288178 0.4851287305355072 +CXCL12 True 3.0 Endothelial Cells 1.3608534322820036 0.47993969917297363 +CXCL12 True 4.0 Macrophages 1.0893550893550894 0.40663039684295654 +CXCL12 True 5.0 Pericytes 1.0134784221590207 0.37875601649284363 +CXCR3 True 1.0 T Lymphocytes 0.034048391119980044 0.03280119597911835 +CXCR3 True 2.0 Plasma Cells 0.014891179839633447 0.014891180209815502 +CXCR3 True 3.0 Dendritic Cells 0.011477045908183632 0.010479042306542397 +CXCR3 True 4.0 Myeloid Cells 0.008610086100861008 0.008610086515545845 +CXCR3 True 5.0 Mast Cells 0.008130081300813009 0.008130080997943878 +CXCR4 True 1.0 T Lymphocytes 0.9085806934397606 0.4825392961502075 +CXCR4 True 2.0 Dendritic Cells 0.6749001996007984 0.3540419042110443 +CXCR4 True 3.0 Plasma Cells 0.36769759450171824 0.21305841207504272 +CXCR4 True 4.0 B Cells 0.21934713375796178 0.1675955355167389 +CXCR4 True 5.0 Macrophages 0.1761201761201761 0.1339031308889389 +DLL4 True 1.0 Endothelial Cells 0.476461038961039 0.2467532455921173 +DLL4 True 2.0 Pericytes 0.10634351428218128 0.07703722268342972 +DLL4 True 3.0 Myeloid Cells 0.04551045510455105 0.03198032081127167 +DLL4 True 4.0 11q13 Invasive Tumor Cells (Mitotic) 0.038180341186027617 0.03452477604150772 +DLL4 True 5.0 Plasma Cells 0.020618556701030927 0.019473081454634666 +EMCN True 1.0 Endothelial Cells 1.4728664192949907 0.6341604590415955 +EMCN True 2.0 Pericytes 0.32274020032150363 0.21491281688213348 +EMCN True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.09057676685621446 0.07514216005802155 +EMCN True 4.0 Myeloid Cells 0.06888068880688807 0.05781057849526405 +EMCN True 5.0 Plasma Cells 0.06758304696449026 0.05841924250125885 +FLT1 True 1.0 Endothelial Cells 1.5473098330241188 0.6168830990791321 +FLT1 True 2.0 Pericytes 0.3560034623469766 0.23519228398799896 +FLT1 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.24654752233956134 0.20633630454540253 +FLT1 True 4.0 Myeloid Cells 0.21648216482164823 0.16851168870925903 +FLT1 True 5.0 Apocrine Cells 0.15632754342431762 0.14640198647975922 +HES1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 0.4435418359057677 0.307879775762558 +HES1 True 2.0 Luminal-like Amorphous DCIS Cells 0.40067546822229044 0.2689591646194458 +HES1 True 3.0 11q13 Invasive Tumor Cells (G1/S) 0.33403538331929233 0.24136479198932648 +HES1 True 4.0 11q13 Invasive Tumor Cells 0.2922418639515273 0.21926729381084442 +HES1 True 5.0 Basal-like Structured DCIS Cells 0.2264840182648402 0.1742009073495865 +HEY1 True 1.0 Endothelial Cells 0.24570964749536178 0.15584415197372437 +HEY1 True 2.0 11q13 Invasive Tumor Cells (Mitotic) 0.17749796913078797 0.1486596316099167 +HEY1 True 3.0 Basal-like Structured DCIS Cells 0.1430365296803653 0.10844749212265015 +HEY1 True 4.0 Myoepithelial Cells 0.1268073003081299 0.10630480945110321 +HEY1 True 5.0 Myeloid Cells 0.10947109471094711 0.08733087033033371 +HSPG2 True 1.0 Endothelial Cells 5.104359925788497 0.8711734414100647 +HSPG2 True 2.0 CAFs, Invasive Associated 2.2671832041989504 0.6923269033432007 +HSPG2 True 3.0 Pericytes 1.1843699765055027 0.48237913846969604 +HSPG2 True 4.0 CAFs, DCIS Associated 0.8459618689141641 0.4324932396411896 +HSPG2 True 5.0 Myoepithelial Cells 0.5875799952595402 0.3209291398525238 +IL7R True 1.0 T Lymphocytes 0.20990271888251436 0.15851832926273346 +IL7R True 2.0 Myeloid Cells 0.05289052890528905 0.046740468591451645 +IL7R True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.05280259951259139 0.05158407613635063 +IL7R True 4.0 Apocrine Cells 0.04714640198511166 0.04466501250863075 +IL7R True 5.0 Dendritic Cells 0.046656686626746505 0.037425149232149124 +JAG1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 1.9065800162469537 0.7083671689033508 +JAG1 True 2.0 11q13 Invasive Tumor Cells 1.4774345680554688 0.6293959617614746 +JAG1 True 3.0 11q13 Invasive Tumor Cells (G1/S) 1.3336141533277168 0.5867733955383301 +JAG1 True 4.0 Luminal-like Amorphous DCIS Cells 1.0723825606386246 0.5086736083030701 +JAG1 True 5.0 Basal-like Structured DCIS Cells 0.6257990867579909 0.3481735289096832 +KDR True 1.0 Endothelial Cells 2.37569573283859 0.6372912526130676 +KDR True 2.0 Pericytes 0.6527760603437616 0.3185359239578247 +KDR True 3.0 CAFs, Invasive Associated 0.10547363159210198 0.06723318994045258 +KDR True 4.0 Myeloid Cells 0.09471094710947109 0.084870845079422 +KDR True 5.0 Basal-like Structured DCIS Cells 0.08367579908675798 0.06061643734574318 +LCK True 1.0 T Lymphocytes 0.6152407084060864 0.3986031413078308 +LCK True 2.0 B Cells 0.11544585987261147 0.0927547737956047 +LCK True 3.0 Plasma Cells 0.08476517754868271 0.06643757224082947 +LCK True 4.0 Myeloid Cells 0.06150061500615006 0.05166051536798477 +LCK True 5.0 Dendritic Cells 0.058632734530938126 0.04466067999601364 +LRP1 True 1.0 CAFs, Invasive Associated 2.662834291427143 0.7233191728591919 +LRP1 True 2.0 CAFs, DCIS Associated 2.585713116766222 0.7374191880226135 +LRP1 True 3.0 Dendritic Cells 1.0197105788423153 0.44386228919029236 +LRP1 True 4.0 Macrophages 0.9233359233359233 0.440559446811676 +LRP1 True 5.0 Myoepithelial Cells 0.4869637354823418 0.302085816860199 +MMP2 True 1.0 CAFs, DCIS Associated 1.4687423287783323 0.5307257771492004 +MMP2 True 2.0 CAFs, Invasive Associated 1.3129217695576105 0.4966258406639099 +MMP2 True 3.0 Endothelial Cells 0.2912801484230056 0.1832096427679062 +MMP2 True 4.0 Dendritic Cells 0.2657185628742515 0.15668663382530212 +MMP2 True 5.0 Myoepithelial Cells 0.2623844512917753 0.1821521669626236 +MMRN2 True 1.0 Endothelial Cells 1.2184601113172542 0.5637755393981934 +MMRN2 True 2.0 Pericytes 0.2594287127488562 0.17744527757167816 +MMRN2 True 3.0 Basal-like Structured DCIS Cells 0.06746575342465753 0.05319634824991226 +MMRN2 True 4.0 Myoepithelial Cells 0.06245555818914435 0.05131547898054123 +MMRN2 True 5.0 Mast Cells 0.04607046070460705 0.0379403792321682 +MYC True 1.0 Basal-like Structured DCIS Cells 1.5598173515981735 0.5699771642684937 +MYC True 2.0 Endothelial Cells 1.1174628942486085 0.4582560360431671 +MYC True 3.0 11q13 Invasive Tumor Cells (G1/S) 0.9334456613310868 0.45408591628074646 +MYC True 4.0 11q13 Invasive Tumor Cells 0.8824879755137734 0.44670185446739197 +MYC True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.8273761169780666 0.43013811111450195 +NOTCH1 True 1.0 Endothelial Cells 0.5613404452690167 0.35366418957710266 +NOTCH1 True 2.0 Basal-like Structured DCIS Cells 0.4221461187214612 0.263812780380249 +NOTCH1 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.30381803411860275 0.22542648017406464 +NOTCH1 True 4.0 Pericytes 0.22517620873006058 0.15951527655124664 +NOTCH1 True 5.0 Myoepithelial Cells 0.2188907324010429 0.15868689119815826 +NOTCH2 True 1.0 Apocrine Cells 2.1861042183622827 0.7171216011047363 +NOTCH2 True 2.0 11q13 Invasive Tumor Cells 1.3958398400899494 0.607002317905426 +NOTCH2 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 1.334281072298944 0.6255077123641968 +NOTCH2 True 4.0 Luminal-like Amorphous DCIS Cells 1.1538992938286767 0.5558028817176819 +NOTCH2 True 5.0 11q13 Invasive Tumor Cells (G1/S) 1.0602358887952823 0.5395956039428711 +NOTCH3 True 1.0 Pericytes 2.3809818226783728 0.5623840689659119 +NOTCH3 True 2.0 CAFs, Invasive Associated 1.1647088227943014 0.4973756670951843 +NOTCH3 True 3.0 Luminal-like Amorphous DCIS Cells 0.9322229045133559 0.4947804808616638 +NOTCH3 True 4.0 Endothelial Cells 0.7337662337662337 0.27516233921051025 +NOTCH3 True 5.0 Basal-like Structured DCIS Cells 0.6931506849315069 0.3960045576095581 +NOTCH4 True 1.0 Endothelial Cells 0.4457328385899815 0.28038033843040466 +NOTCH4 True 2.0 Myoepithelial Cells 0.10997866793078928 0.09042426943778992 +NOTCH4 True 3.0 Pericytes 0.08445653517991838 0.0650426596403122 +NOTCH4 True 4.0 Basal-like Structured DCIS Cells 0.07682648401826483 0.06255707889795303 +NOTCH4 True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.07636068237205523 0.06986190378665924 +PDGFRB True 1.0 CAFs, Invasive Associated 0.6135966008497875 0.3709072768688202 +PDGFRB True 2.0 Pericytes 0.42549771237789047 0.2529986500740051 +PDGFRB True 3.0 CAFs, DCIS Associated 0.32493249324932494 0.2368464171886444 +PDGFRB True 4.0 Endothelial Cells 0.15213358070500926 0.10227272659540176 +PDGFRB True 5.0 Dendritic Cells 0.05189620758483034 0.0416666679084301 +PECAM1 True 1.0 Endothelial Cells 4.5438311688311686 0.8918135166168213 +PECAM1 True 2.0 Plasma Cells 1.7445589919816724 0.6300114393234253 +PECAM1 True 3.0 Pericytes 1.0775318412266601 0.4703845679759979 +PECAM1 True 4.0 Dendritic Cells 0.7437624750499002 0.4149201512336731 +PECAM1 True 5.0 Macrophages 0.4421134421134421 0.28671327233314514 +PLAT True 1.0 11q13 Invasive Tumor Cells 8.869838840652132 0.956024706363678 +PLAT True 2.0 11q13 Invasive Tumor Cells (Mitotic) 7.280259951259139 0.9549146890640259 +PLAT True 3.0 11q13 Invasive Tumor Cells (G1/S) 6.233361415332772 0.9182813763618469 +PLAT True 4.0 Apocrine Cells 3.3101736972704714 0.8114144206047058 +PLAT True 5.0 Luminal-like Amorphous DCIS Cells 2.8183143997543754 0.6322535872459412 +RGS5 True 1.0 Pericytes 0.6418943984172129 0.3001112937927246 +RGS5 True 2.0 Endothelial Cells 0.5906771799628943 0.3025278151035309 +RGS5 True 3.0 CAFs, Invasive Associated 0.10747313171707074 0.06723318994045258 +RGS5 True 4.0 Myeloid Cells 0.07995079950799508 0.06519065052270889 +RGS5 True 5.0 Mast Cells 0.07859078590785908 0.0731707289814949 +SELP True 1.0 Endothelial Cells 0.7355055658627088 0.259508341550827 +SELP True 2.0 Pericytes 0.10980586125881044 0.07270928472280502 +SELP True 3.0 T Lymphocytes 0.06023946121227239 0.050511348992586136 +SELP True 4.0 Myeloid Cells 0.05166051660516605 0.04428044334053993 +SELP True 5.0 Plasma Cells 0.043528064146620846 0.03665521368384361 +SERPINE1 True 1.0 CAFs, Invasive Associated 0.3504123969007748 0.20569857954978943 +SERPINE1 True 2.0 Myoepithelial Cells 0.05724105238208106 0.03507940098643303 +SERPINE1 True 3.0 Endothelial Cells 0.05322356215213358 0.04012059420347214 +SERPINE1 True 4.0 CAFs, DCIS Associated 0.04107683495622289 0.03358972445130348 +SERPINE1 True 5.0 Dendritic Cells 0.036926147704590816 0.03168662637472153 +THBD True 1.0 Endothelial Cells 0.8287337662337663 0.40491652488708496 +THBD True 2.0 Pericytes 0.2860145913194015 0.18770866096019745 +THBD True 3.0 Dendritic Cells 0.1217564870259481 0.09356287121772766 +THBD True 4.0 CAFs, Invasive Associated 0.10847288177955511 0.0794801265001297 +THBD True 5.0 Myeloid Cells 0.08487084870848709 0.07503075152635574 +THBS2 True 1.0 CAFs, Invasive Associated 1.8375406148462885 0.5576105713844299 +THBS2 True 2.0 CAFs, DCIS Associated 1.6160297847966616 0.5173472166061401 +THBS2 True 3.0 Dendritic Cells 0.1317365269461078 0.071856290102005 +THBS2 True 4.0 CXCL14+ Fibroblasts 0.11588330632090761 0.07698541134595871 +THBS2 True 5.0 Pericytes 0.1151230369729195 0.07122542709112167 +TRAC True 1.0 T Lymphocytes 2.8600648540783236 0.7904714345932007 +TRAC True 2.0 B Cells 0.6871019108280255 0.3626592457294464 +TRAC True 3.0 Plasma Cells 0.33791523482245134 0.1477663218975067 +TRAC True 4.0 Dendritic Cells 0.24176646706586827 0.1230039894580841 +TRAC True 5.0 CAFs, Invasive Associated 0.15571107223194203 0.10172457247972488 +VWF True 1.0 Endothelial Cells 6.707908163265306 0.8781307935714722 +VWF True 2.0 Pericytes 1.29108445653518 0.4304439127445221 +VWF True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.11169780666125101 0.09423232823610306 +VWF True 4.0 Dendritic Cells 0.11052894211576847 0.05913173779845238 +VWF True 5.0 Mast Cells 0.10840108401084012 0.08130080997943878 diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_false_positive_controls.tsv b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_false_positive_controls.tsv new file mode 100644 index 0000000..000494f --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_false_positive_controls.tsv @@ -0,0 +1,36 @@ +axis_id control_type observed expected_or_control_mean z_or_rank p_or_percentile note +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_abundance_null 13942.0 9916.101448337911 40.577088952341676 0.0 cell-type-label abundance null for graph edge count +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 5.0 3299.0 5.0 0.9987875113670809 rank percentile against all LR pairs in the same sender-receiver cell-type pair +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_abundance_null 11379.0 3280.889960425034 141.55074144031974 0.0 cell-type-label abundance null for graph edge count +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_abundance_null 11604.0 9219.306750089676 24.92068208259856 2.220471678964988e-137 cell-type-label abundance null for graph edge count +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_sender_receiver 2.0 3299.0 2.0 0.9996968778417702 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_abundance_null 21212.0 3024.318857794739 331.09056328473696 0.0 cell-type-label abundance null for graph edge count +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_abundance_null 423716.0 192905.1692550145 567.2684147856648 0.0 cell-type-label abundance null for graph edge count +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_sender_receiver 10.0 3299.0 10.0 0.9972719005759321 rank percentile against all LR pairs in the same sender-receiver cell-type pair +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-SELP|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.690919789894645 0.1174789121765555 6.674917611699146 1.0 matched by global mean expression and detection fraction +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated matched_gene_expression_control 0.8904867455342288 0.1132557384471686 11.234674798948532 1.0 matched by global mean expression and detection fraction +MMRN2-CD93|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.7291144166273554 0.13022764647610297 6.198278570208171 1.0 matched by global mean expression and detection fraction +DLL4-NOTCH3|Endothelial Cells->Pericytes matched_gene_expression_control 0.6103430039507179 0.10700066735274656 8.301941713984622 1.0 matched by global mean expression and detection fraction +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes matched_gene_expression_control 0.7850757124806441 0.1029738649850631 11.218977606863426 1.0 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes matched_gene_expression_control 0.5987173848132842 0.10702942070910819 9.860708047779738 1.0 matched by global mean expression and detection fraction +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells matched_gene_expression_control 0.6593758884575077 0.6351644259334726 0.3126368933035661 0.576 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes component_ablation_max_rank 27.0 16.0 27.0 worst and best rank after removing one score component +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes component_ablation_max_rank 708.0 11.0 708.0 worst and best rank after removing one score component +DLL4-NOTCH3|Endothelial Cells->Pericytes component_ablation_max_rank 86.0 24.0 86.0 worst and best rank after removing one score component +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells component_ablation_max_rank 387.0 32.0 387.0 worst and best rank after removing one score component +MMRN2-CD93|Endothelial Cells->Endothelial Cells component_ablation_max_rank 16.0 9.0 16.0 worst and best rank after removing one score component +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated component_ablation_max_rank 566.0 2.0 566.0 worst and best rank after removing one score component +VWF-SELP|Endothelial Cells->Endothelial Cells component_ablation_max_rank 13.0 1.0 13.0 worst and best rank after removing one score component diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_matched_gene_controls.tsv b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_matched_gene_controls.tsv new file mode 100644 index 0000000..59725eb --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_matched_gene_controls.tsv @@ -0,0 +1,8 @@ +axis_id matched_gene_status n_controls observed_expression_specificity_score control_mean control_sd matched_gene_z matched_gene_percentile +VWF-SELP|Endothelial Cells->Endothelial Cells success 250 0.690919789894645 0.1174789121765555 0.08590980609453787 6.674917611699146 1.0 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 250 0.8904867455342288 0.1132557384471686 0.06918144236447345 11.234674798948532 1.0 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 250 0.7291144166273554 0.13022764647610297 0.09662146729412627 6.198278570208171 1.0 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 250 0.6103430039507179 0.10700066735274656 0.060629471265751134 8.301941713984622 1.0 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 250 0.7850757124806441 0.1029738649850631 0.06079893118587669 11.218977606863426 1.0 +CD48-CD2|T Lymphocytes->T Lymphocytes success 250 0.5987173848132842 0.10702942070910819 0.04986335278579571 9.860708047779738 1.0 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 250 0.6593758884575077 0.6351644259334726 0.07744275561402209 0.3126368933035661 0.576 diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_spatial_null_summary.tsv b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_spatial_null_summary.tsv new file mode 100644 index 0000000..b93a219 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_spatial_null_summary.tsv @@ -0,0 +1,8 @@ +axis_id observed_cross_edge_count expected_cross_edge_count_abundance_null cross_edge_enrichment_fold cross_edge_enrichment_z cross_edge_enrichment_p_approx local_contact contact_coverage within_sender_receiver_rank within_sender_receiver_n within_sender_receiver_percentile within_lr_pair_rank within_lr_pair_n within_lr_pair_percentile +VWF-SELP|Endothelial Cells->Endothelial Cells 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.2912449657481761 0.1111198059316065 1 3299 1.0 1 400 1.0 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 13942 9916.101448337911 1.4059961036740796 40.577088952341676 0.0 0.3461937505325735 0.1319036006311863 1 3299 1.0 1 400 1.0 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.1484661470807383 0.0288754988653259 5 3299 0.9987875113670809 1 400 1.0 +DLL4-NOTCH3|Endothelial Cells->Pericytes 11379 3280.889960425034 3.4682662744732435 141.55074144031974 0.0 0.135465098207694 0.0303190087002372 1 3299 1.0 1 400 1.0 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 11604 9219.306750089676 1.258662968328625 24.92068208259856 2.220471678964988e-137 0.1684304172162009 0.0450706652878317 2 3299 0.9996968778417702 1 400 1.0 +CD48-CD2|T Lymphocytes->T Lymphocytes 21212 3024.318857794739 7.0138107115687145 331.09056328473696 0.0 0.1241603897223811 0.0154158023760135 1 3299 1.0 1 400 1.0 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 423716 192905.1692550145 2.1964989410929725 567.2684147856648 0.0 0.1231934200799743 0.0168391092146626 10 3299 0.9972719005759321 1 400 1.0 diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_validation_evidence.tsv b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_validation_evidence.tsv new file mode 100644 index 0000000..b0758c8 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/tables/topolink_cci_validation_evidence.tsv @@ -0,0 +1,15 @@ +axis_id biology_label ligand receptor sender_celltype receiver_celltype CCI_score global_rank sender_anchor receiver_anchor structure_bridge sender_expr receiver_expr local_contact_x prior_confidence cross_edge_count sender receiver ligand_sender_mean ligand_sender_detection_fraction ligand_sender_celltype_rank ligand_sender_specificity_ratio receptor_receiver_mean receptor_receiver_detection_fraction receptor_receiver_celltype_rank receptor_receiver_specificity_ratio observed_cross_edge_count expected_cross_edge_count_abundance_null cross_edge_enrichment_fold cross_edge_enrichment_z cross_edge_enrichment_p_approx local_contact_y contact_coverage within_sender_receiver_rank within_sender_receiver_n within_sender_receiver_percentile within_lr_pair_rank within_lr_pair_n within_lr_pair_percentile matched_gene_status n_controls observed_expression_specificity_score control_mean control_sd matched_gene_z matched_gene_percentile max_rank_after_component_removal min_rank_after_component_removal cross_method_exact_count cross_method_same_lr_count cross_method_same_sender_receiver_count supporting_methods_exact supporting_methods_same_lr target_panel_present_n receiver_context_panel_score receiver_context_panel_genes expression_support spatial_abundance_null_support matched_gene_control_support component_ablation_support cross_method_support receiver_context_support support_count evidence_class axis_label +VWF-SELP|Endothelial Cells->Endothelial Cells WPB / endothelial activation VWF SELP Endothelial Cells Endothelial Cells 0.7912892368005828 1 0.955713094717548 0.8819126042133903 1.0 1.0 1.0 0.2912449657481761 1.0 12779 Endothelial Cells Endothelial Cells 6.707908163265306 0.8781307935714722 1 1.0 0.7355055658627088 0.259508341550827 1 1.0 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.2912449657481761 0.1111198059316065 1 3299 1.0 1 400 1.0 success 250 0.690919789894645 0.1174789121765555 0.08590980609453787 6.674917611699146 1.0 13 1 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 6 0.6656207262750022 VWF,SELP,ANGPT2,THBD,PLAT,SERPINE1 True True True True True True 6 strong "VWF-SELP +Endothelial Cells -> Endothelial Cells" +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated vascular-stromal matrix/scavenger axis VWF LRP1 Endothelial Cells CAFs, DCIS Associated 0.7479758913021439 2 0.955713094717548 0.7346293219749174 0.7204611100467462 1.0 1.0 0.3461937505325735 1.0 13942 Endothelial Cells CAFs, DCIS Associated 6.707908163265306 0.8781307935714722 1 1.0 2.585713116766222 0.7374191880226135 2 0.971037936942149 13942 9916.101448337911 1.4059961036740796 40.577088952341676 0.0 0.3461937505325735 0.1319036006311863 1 3299 1.0 1 400 1.0 success 250 0.8904867455342288 0.1132557384471686 0.06918144236447345 11.234674798948532 1.0 566 2 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 7 0.5161052675482147 VWF,LRP1,HSPG2,COL4A1,COL4A2,MMP2,THBS2 True True True False True True 5 strong "VWF-LRP1 +Endothelial Cells -> CAFs, DCIS Associated" +MMRN2-CD93|Endothelial Cells->Endothelial Cells CD93-MMRN2 angiogenesis MMRN2 CD93 Endothelial Cells Endothelial Cells 0.7107166026857937 10 0.9845127857250529 0.8817184225858201 1.0 1.0 1.0 0.1484661470807383 1.0 12779 Endothelial Cells Endothelial Cells 1.2184601113172542 0.5637755393981934 1 1.0 0.9689239332096475 0.5012755393981934 1 1.0 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.1484661470807383 0.0288754988653259 5 3299 0.9987875113670809 1 400 1.0 success 250 0.7291144166273554 0.13022764647610297 0.09662146729412627 6.198278570208171 1.0 16 9 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 7 1.0 MMRN2,CD93,CLEC14A,KDR,FLT1,PECAM1,EMCN True True True True True True 6 strong "MMRN2-CD93 +Endothelial Cells -> Endothelial Cells" +CD48-CD2|T Lymphocytes->T Lymphocytes T-cell adhesion/co-stimulation CD48 CD2 T Lymphocytes T Lymphocytes 0.6849877065459009 16 0.928447473463448 0.8960994285623033 1.0 1.0 1.0 0.1241603897223811 1.0 21212 T Lymphocytes T Lymphocytes 0.5604888999750561 0.37989524006843567 1 1.0 0.49837864804190574 0.3382389545440674 1 1.0 21212 3024.318857794739 7.0138107115687145 331.09056328473696 0.0 0.1241603897223811 0.0154158023760135 1 3299 1.0 1 400 1.0 success 250 0.5987173848132842 0.10702942070910819 0.04986335278579571 9.860708047779738 1.0 27 16 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 7 1.0 CD48,CD2,CD3D,CD3E,TRAC,IL7R,LCK True True True True True True 6 strong "CD48-CD2 +T Lymphocytes -> T Lymphocytes" +DLL4-NOTCH3|Endothelial Cells->Pericytes endothelial-pericyte Notch DLL4 NOTCH3 Endothelial Cells Pericytes 0.6695148471220083 24 0.9184503888425788 0.8818326005152037 0.946515890536252 1.0 0.8672894033034337 0.135465098207694 1.0 11379 Endothelial Cells Pericytes 0.476461038961039 0.2467532455921173 1 1.0 2.3809818226783728 0.5623840689659119 1 1.0 11379 3280.889960425034 3.4682662744732435 141.55074144031974 0.0 0.135465098207694 0.0303190087002372 1 3299 1.0 1 400 1.0 success 250 0.6103430039507179 0.10700066735274656 0.060629471265751134 8.301941713984622 1.0 86 24 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 8 0.48688694950414185 DLL4,NOTCH3,NOTCH4,JAG1,HEY1,HES1,PDGFRB,RGS5 True True True True True False 5 strong "DLL4-NOTCH3 +Endothelial Cells -> Pericytes" +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes CAF-immune chemokine recruitment CXCL12 CXCR4 CAFs, DCIS Associated T Lymphocytes 0.6616803690861207 28 0.8924110508951895 0.9008184599638702 0.6198216015396206 1.0 1.0 0.1684304172162009 1.0 11604 CAFs, DCIS Associated T Lymphocytes 3.649660420587513 0.7872514724731445 1 1.0 0.9085806934397606 0.4825392961502075 1 1.0 11604 9219.306750089676 1.258662968328625 24.92068208259856 2.220471678964988e-137 0.1684304172162009 0.0450706652878317 2 3299 0.9996968778417702 1 400 1.0 success 250 0.7850757124806441 0.1029738649850631 0.06079893118587669 11.218977606863426 1.0 708 11 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 8 0.7664489835769633 CXCL12,CXCR4,CXCR3,CCL19,CCL21,CD3D,CD3E,IL7R True True True False True True 5 strong "CXCL12-CXCR4 +CAFs, DCIS Associated -> T Lymphocytes" +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells tumor-intrinsic Notch signaling JAG1 NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6339181063246662 45 0.7941469661104034 0.663300745568453 1.0 1.0 1.0 0.1231934200799743 1.0 423716 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 1.4774345680554688 0.6293959617614746 2 0.7749134866963281 1.3958398400899494 0.607002317905426 2 0.6385056249219633 423716 192905.1692550145 2.1964989410929725 567.2684147856648 0.0 0.1231934200799743 0.0168391092146626 10 3299 0.9972719005759321 1 400 1.0 success 250 0.6593758884575077 0.6351644259334726 0.07744275561402209 0.3126368933035661 0.576 387 32 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 7 0.5860530033828537 JAG1,NOTCH2,NOTCH1,HES1,HEY1,MYC,CCND1 True True False False True True 4 moderate "JAG1-NOTCH2 +11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells" diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/topolink_cci_false_positive_controls.tsv b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/topolink_cci_false_positive_controls.tsv new file mode 100644 index 0000000..000494f --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/topolink_cci_false_positive_controls.tsv @@ -0,0 +1,36 @@ +axis_id control_type observed expected_or_control_mean z_or_rank p_or_percentile note +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_abundance_null 13942.0 9916.101448337911 40.577088952341676 0.0 cell-type-label abundance null for graph edge count +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 5.0 3299.0 5.0 0.9987875113670809 rank percentile against all LR pairs in the same sender-receiver cell-type pair +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_abundance_null 11379.0 3280.889960425034 141.55074144031974 0.0 cell-type-label abundance null for graph edge count +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_abundance_null 11604.0 9219.306750089676 24.92068208259856 2.220471678964988e-137 cell-type-label abundance null for graph edge count +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_sender_receiver 2.0 3299.0 2.0 0.9996968778417702 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_abundance_null 21212.0 3024.318857794739 331.09056328473696 0.0 cell-type-label abundance null for graph edge count +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_abundance_null 423716.0 192905.1692550145 567.2684147856648 0.0 cell-type-label abundance null for graph edge count +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_sender_receiver 10.0 3299.0 10.0 0.9972719005759321 rank percentile against all LR pairs in the same sender-receiver cell-type pair +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-SELP|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.690919789894645 0.1174789121765555 6.674917611699146 1.0 matched by global mean expression and detection fraction +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated matched_gene_expression_control 0.8904867455342288 0.1132557384471686 11.234674798948532 1.0 matched by global mean expression and detection fraction +MMRN2-CD93|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.7291144166273554 0.13022764647610297 6.198278570208171 1.0 matched by global mean expression and detection fraction +DLL4-NOTCH3|Endothelial Cells->Pericytes matched_gene_expression_control 0.6103430039507179 0.10700066735274656 8.301941713984622 1.0 matched by global mean expression and detection fraction +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes matched_gene_expression_control 0.7850757124806441 0.1029738649850631 11.218977606863426 1.0 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes matched_gene_expression_control 0.5987173848132842 0.10702942070910819 9.860708047779738 1.0 matched by global mean expression and detection fraction +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells matched_gene_expression_control 0.6593758884575077 0.6351644259334726 0.3126368933035661 0.576 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes component_ablation_max_rank 27.0 16.0 27.0 worst and best rank after removing one score component +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes component_ablation_max_rank 708.0 11.0 708.0 worst and best rank after removing one score component +DLL4-NOTCH3|Endothelial Cells->Pericytes component_ablation_max_rank 86.0 24.0 86.0 worst and best rank after removing one score component +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells component_ablation_max_rank 387.0 32.0 387.0 worst and best rank after removing one score component +MMRN2-CD93|Endothelial Cells->Endothelial Cells component_ablation_max_rank 16.0 9.0 16.0 worst and best rank after removing one score component +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated component_ablation_max_rank 566.0 2.0 566.0 worst and best rank after removing one score component +VWF-SELP|Endothelial Cells->Endothelial Cells component_ablation_max_rank 13.0 1.0 13.0 worst and best rank after removing one score component diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/topolink_cci_validation_scoreboard.md b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/topolink_cci_validation_scoreboard.md new file mode 100644 index 0000000..c5a6269 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_false_positive_controls_shared/topolink_cci_validation_scoreboard.md @@ -0,0 +1,41 @@ +# TopoLink-CCI validation evidence scoreboard + +This PDC run applies the computational false-positive-control logic used by classic CCC/LR papers: expression specificity, spatial/label nulls, matched-gene controls, component ablation, cross-method triangulation, and receiver-context support. It is computational evidence, not wet-lab proof. + +## Evidence classes + +- Strong axes: 6 +- Moderate axes: 1 +- Hypothesis-only axes: 0 + +axis_label biology_label CCI_score global_rank evidence_class support_count cross_method_same_lr_count matched_gene_percentile cross_edge_enrichment_z max_rank_after_component_removal +"VWF-SELP +Endothelial Cells -> Endothelial Cells" WPB / endothelial activation 0.7912892368005828 1 strong 6 5 1.0 157.09499064265975 13 +"VWF-LRP1 +Endothelial Cells -> CAFs, DCIS Associated" vascular-stromal matrix/scavenger axis 0.7479758913021439 2 strong 5 5 1.0 40.577088952341676 566 +"MMRN2-CD93 +Endothelial Cells -> Endothelial Cells" CD93-MMRN2 angiogenesis 0.7107166026857937 10 strong 6 5 1.0 157.09499064265975 16 +"CD48-CD2 +T Lymphocytes -> T Lymphocytes" T-cell adhesion/co-stimulation 0.6849877065459009 16 strong 6 5 1.0 331.09056328473696 27 +"DLL4-NOTCH3 +Endothelial Cells -> Pericytes" endothelial-pericyte Notch 0.6695148471220083 24 strong 5 5 1.0 141.55074144031974 86 +"CXCL12-CXCR4 +CAFs, DCIS Associated -> T Lymphocytes" CAF-immune chemokine recruitment 0.6616803690861207 28 strong 5 5 1.0 24.92068208259856 708 +"JAG1-NOTCH2 +11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells" tumor-intrinsic Notch signaling 0.6339181063246662 45 moderate 4 5 0.576 567.2684147856648 387 + + +## Control interpretation + +- `spatial_abundance_null`: compares observed sender-receiver graph edges with a label-abundance null; it is conservative about exact geometry but catches cell-type-pair edge enrichment. +- `matched_gene_control`: compares ligand/receptor sender-receiver expression specificity with genes matched by global mean and detection. +- `lr_label_permutation`: reports where the candidate ranks within the same sender-receiver cell-type pair and within the same LR pair across cell-type pairs. +- `component_ablation`: recomputes geometric-mean LR scores after removing one pyXenium component at a time. + +## References to validation patterns + +- CellPhoneDB: curated LR database, complex filtering, and cell-label permutation specificity. +- CellChat: mass-action communication probability, curated cofactors/complexes, and label permutation. +- NicheNet: downstream receiver target-gene support rather than co-expression alone. +- stLearn/SpatialDM/Squidpy: spatially constrained LR evidence and permutation/random-pair controls. +- LIANA benchmark: multi-method consensus and rank aggregation because no single LR score is ground truth. diff --git a/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_validation_shared_20101850.stderr.log b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_validation_shared_20101850.stderr.log new file mode 100644 index 0000000..085a9c2 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_collected/topolink_cci_validation_shared_20101850.stderr.log @@ -0,0 +1,23 @@ + Command being timed: "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/envs/python/pyxenium/bin/python /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/repo/benchmarking/cci_2026_atera/scripts/topolink_cci_validation_framework.py --root /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04 --output-dir /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_false_positive_controls_shared --n-matched-controls 250 --seed 20260428" + User time (seconds): 61.97 + System time (seconds): 6.23 + Percent of CPU this job got: 97% + Elapsed (wall clock) time (h:mm:ss or m:ss): 1:10.11 + Average shared text size (kbytes): 0 + Average unshared data size (kbytes): 0 + Average stack size (kbytes): 0 + Average total size (kbytes): 0 + Maximum resident set size (kbytes): 8749684 + Average resident set size (kbytes): 0 + Major (requiring I/O) page faults: 3035 + Minor (reclaiming a frame) page faults: 424067 + Voluntary context switches: 14563 + Involuntary context switches: 615 + Swaps: 0 + File system inputs: 1822958 + File system outputs: 688 + Socket messages sent: 0 + Socket messages received: 0 + Signals delivered: 0 + Page size (bytes): 4096 + Exit status: 0 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/figures/topolink_cci_validation_v2_evidence_matrix.pdf b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/figures/topolink_cci_validation_v2_evidence_matrix.pdf new file mode 100644 index 0000000000000000000000000000000000000000..00b26e89d15213638f09957ca6973f74adcf4001 GIT binary patch literal 31395 zcmd431yohd_diU7q_p%!8p(Svmqxllx6fVAo=qu_4BF#GX6~*-ajhl+*?8E3cz>2BYv%ye7Q`*<0H{FP%EH;w3NEy}hntm|BeqxCbAuVT z8QA3q>$;1tQ;JPFwl}0~9KLDT#6zn@6s(0Fs9E*s$db>*e>~c0%3_QQke46Dr=?b) zav7#I9p)0>JLGtjth)DMKofk$s`qV$LJab^&_{OyVlod86n%`A7mRy$Cq&$XR@Tc- z;*~YS7N(BtjyaBFXfhXfQRIxRja*9v2>q~6+Dm;ve4&8o#{e{qS4W&ONU)7Z!N#)`rtWJMnZHDn8GV_u>TWj 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"/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_validation_v2", + "expected_score_rows": 1319600, + "n_label_permutations": 500, + "n_spatial_permutations": 300, + "n_spatial_matched_pairs": 120, + "n_matched_controls": 250, + "n_downstream_permutations": 120, + "n_bootstraps": 5, + "bootstrap_fraction": 0.8, + "k_neighbors": 10, + "seed": 20260428 +} \ No newline at end of file diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/publication_figures/figure_caption.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/publication_figures/figure_caption.md new file mode 100644 index 0000000..f12d544 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/publication_figures/figure_caption.md @@ -0,0 +1,10 @@ +# Figure caption + +**Figure. TopoLink-CCI discoveries pass multi-layer computational false-positive controls.** +**A**, Schematic of the validation framework. pyXenium nominates candidate ligand-receptor axes, which are then evaluated with validation principles adapted from CellPhoneDB/Squidpy, CellChat, stLearn/SpatialDM, NicheNet, LIANA, and pyXenium-specific robustness checks. +**B**, Evidence matrix across seven biologically interpretable LR axes. Filled circles indicate evidence layers that passed the pre-specified thresholds. All seven axes were classified as strong and none were flagged as contamination/artifact risk. +**C**, Quantitative strength of selected controls: cell-label permutation FDR, spatial-null FDR, matched-gene z-score, and downstream target FDR. The top-ranked axis, VWF-SELP, had CCI_score=0.791, label-permutation FDR=0.002, spatial-null FDR=0.00465, and matched-gene z=6.67. +**D**, Bootstrap and component-ablation robustness. Bootstrap ranks are medians from five 80% stratified resamples; ablation shows the worst rank after removing one pyXenium score component at a time. +**E**, Biological interpretation cards for the retained LR axes. These results support computational credibility, but do not prove protein-level ligand-receptor binding, secretion, or functional causality. + +Supplementary Fig. S1 visualizes saved null summaries in standardized z-space; raw permutation draws were not retained. Supplementary Fig. S2 shows per-axis validation cards and weak evidence layers. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/publication_figures/figure_caption_readable.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/publication_figures/figure_caption_readable.md new file mode 100644 index 0000000..808d280 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/publication_figures/figure_caption_readable.md @@ -0,0 +1,8 @@ +# Readable figure caption + +**Figure. Orthogonal computational controls support TopoLink-CCI discoveries.** +**A**, TopoLink-CCI scores are used to nominate candidate ligand-receptor axes, which are then tested with independent control layers adapted from classic LR/CCC methods: permutation, spatial nulls, matched-gene controls, downstream/received-signal support, cross-method consensus, component ablation, and bootstrap stability. +**B**, Readable evidence table for seven biologically interpretable LR axes, ordered by pyXenium rank. The compact gates show label permutation, spatial null, matched-gene control, and downstream target support; full nine-layer support is included in source data. All seven axes are classified as strong. `CXCL12-CXCR4` is spatial-null weak but supported by other evidence layers; `JAG1-NOTCH2` has weaker matched-gene/downstream support but still meets the strong threshold. +**C**, Summary support counts and interpretive take-home points. 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The result should be read as computational validation, not wet-lab proof. + +## Summary + +- strong: 7 +- moderate: 0 +- hypothesis_only: 0 +- artifact_risk: 0 + +ligand receptor sender receiver CCI_score pyxenium_rank evidence_class support_count cell_label_perm_fdr spatial_null_fdr matched_gene_z downstream_target_fdr cross_method_same_lr_count bootstrap_rank_median contamination_flag +VWF SELP Endothelial Cells Endothelial Cells 0.7912892368005828 1 strong 8 0.001996007984031936 0.004651162790697674 6.674917611699146 0.027184466019417475 5 1.0 False +VWF LRP1 Endothelial Cells CAFs, DCIS Associated 0.7479758913021439 2 strong 8 0.001996007984031936 0.004651162790697674 11.234674798948532 0.029131985731272295 5 3.0 False +MMRN2 CD93 Endothelial Cells Endothelial Cells 0.7107166026857937 10 strong 8 0.001996007984031936 0.004651162790697674 6.198278570208171 0.008323424494649227 5 2.0 False +CD48 CD2 T Lymphocytes T Lymphocytes 0.6849877065459009 16 strong 8 0.001996007984031936 0.011627906976744186 9.860708047779738 0.008323424494649227 5 5.0 False +DLL4 NOTCH3 Endothelial Cells Pericytes 0.6695148471220083 24 strong 8 0.001996007984031936 0.004651162790697674 8.301941713984622 0.025494276795005204 5 6.0 False +CXCL12 CXCR4 CAFs, DCIS Associated T Lymphocytes 0.6616803690861207 28 strong 7 0.001996007984031936 0.5813953488372093 11.218977606863426 0.025494276795005204 5 4.0 False +JAG1 NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6339181063246662 45 strong 6 0.001996007984031936 0.004651162790697674 0.3126368933035661 0.6076099881093936 5 7.0 False + + +## Evidence layers implemented + +- CellPhoneDB/Squidpy-style cell-label permutation of ligand/receptor communication probability. +- CellChat-style sender/receiver group specificity and permutation significance. +- stLearn-style spatial-neighborhood LR co-expression plus matched-expression random gene pairs. +- SpatialDM-style spatial expression null based on ligand/receptor neighborhood coupling. +- NicheNet-style receiver target/pathway support using predefined biology panels. +- COMMOT/SpaTalk-style received-signal association with receiver target programs. +- LIANA-style cross-method consensus across completed benchmark methods. +- pyXenium component ablation and stratified bootstrap stability. + +## Caveat + +The framework reduces false-positive risk, but protein-level receptor binding, secretion, and functional causality require orthogonal experimental validation. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/CD48_CD2_T_Lymphocytes_T_Lymphocytes.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/CD48_CD2_T_Lymphocytes_T_Lymphocytes.md new file mode 100644 index 0000000..78eedae --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/CD48_CD2_T_Lymphocytes_T_Lymphocytes.md @@ -0,0 +1,25 @@ +# CD48-CD2: T Lymphocytes -> T Lymphocytes + +- Biology label: T-cell adhesion/co-stimulation +- TopoLink-CCI_score: 0.684988 +- pyXenium rank: 16 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.011627906976744186 +- `matched_gene_z`: 9.860708047779738 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 11.544674396514893 +- `downstream_target_fdr`: 0.008323424494649227 +- `received_signal_target_spearman`: 0.4228849179250702 +- `cross_method_exact_count`: 5 +- `cross_method_same_lr_count`: 5 +- `bootstrap_rank_median`: 5.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/CXCL12_CXCR4_CAFs_DCIS_Associated_T_Lymphocytes.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/CXCL12_CXCR4_CAFs_DCIS_Associated_T_Lymphocytes.md new file mode 100644 index 0000000..c673269 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/CXCL12_CXCR4_CAFs_DCIS_Associated_T_Lymphocytes.md @@ -0,0 +1,25 @@ +# CXCL12-CXCR4: CAFs, DCIS Associated -> T Lymphocytes + +- Biology label: CAF-immune chemokine recruitment +- TopoLink-CCI_score: 0.66168 +- pyXenium rank: 28 +- Evidence class: strong +- Supported layers: 7/9 +- Interpretation: strong: 7/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.5813953488372093 +- `matched_gene_z`: 11.218977606863426 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 6.800970241427422 +- `downstream_target_fdr`: 0.025494276795005204 +- `received_signal_target_spearman`: 0.4955612441859473 +- `cross_method_exact_count`: 5 +- `cross_method_same_lr_count`: 5 +- `bootstrap_rank_median`: 4.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/DLL4_NOTCH3_Endothelial_Cells_Pericytes.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/DLL4_NOTCH3_Endothelial_Cells_Pericytes.md new file mode 100644 index 0000000..5d1e52f --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/DLL4_NOTCH3_Endothelial_Cells_Pericytes.md @@ -0,0 +1,25 @@ +# DLL4-NOTCH3: Endothelial Cells -> Pericytes + +- Biology label: endothelial-pericyte Notch +- TopoLink-CCI_score: 0.669515 +- pyXenium rank: 24 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 8.301941713984622 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 2.61274266988039 +- `downstream_target_fdr`: 0.025494276795005204 +- `received_signal_target_spearman`: 0.721750076253441 +- `cross_method_exact_count`: 5 +- `cross_method_same_lr_count`: 5 +- `bootstrap_rank_median`: 6.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/JAG1_NOTCH2_11q13_Invasive_Tumor_Cells_11q13_Invasive_Tumor_Cells.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/JAG1_NOTCH2_11q13_Invasive_Tumor_Cells_11q13_Invasive_Tumor_Cells.md new file mode 100644 index 0000000..8640779 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/JAG1_NOTCH2_11q13_Invasive_Tumor_Cells_11q13_Invasive_Tumor_Cells.md @@ -0,0 +1,25 @@ +# JAG1-NOTCH2: 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells + +- Biology label: tumor-intrinsic Notch signaling +- TopoLink-CCI_score: 0.633918 +- pyXenium rank: 45 +- Evidence class: strong +- Supported layers: 6/9 +- Interpretation: strong: 6/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 0.3126368933035661 +- `matched_gene_percentile`: 0.576 +- `downstream_target_score`: 1.5110729336738586 +- `downstream_target_fdr`: 0.6076099881093936 +- `received_signal_target_spearman`: 0.5874875426315861 +- `cross_method_exact_count`: 5 +- `cross_method_same_lr_count`: 5 +- `bootstrap_rank_median`: 7.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/MMRN2_CD93_Endothelial_Cells_Endothelial_Cells.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/MMRN2_CD93_Endothelial_Cells_Endothelial_Cells.md new file mode 100644 index 0000000..689efcb --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/MMRN2_CD93_Endothelial_Cells_Endothelial_Cells.md @@ -0,0 +1,25 @@ +# MMRN2-CD93: Endothelial Cells -> Endothelial Cells + +- Biology label: CD93-MMRN2 angiogenesis +- TopoLink-CCI_score: 0.710717 +- pyXenium rank: 10 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 6.198278570208171 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 11.116392135620117 +- `downstream_target_fdr`: 0.008323424494649227 +- `received_signal_target_spearman`: 0.4506380910061747 +- `cross_method_exact_count`: 5 +- `cross_method_same_lr_count`: 5 +- `bootstrap_rank_median`: 2.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/VWF_LRP1_Endothelial_Cells_CAFs_DCIS_Associated.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/VWF_LRP1_Endothelial_Cells_CAFs_DCIS_Associated.md new file mode 100644 index 0000000..7ef93e5 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/VWF_LRP1_Endothelial_Cells_CAFs_DCIS_Associated.md @@ -0,0 +1,25 @@ +# VWF-LRP1: Endothelial Cells -> CAFs, DCIS Associated + +- Biology label: vascular-stromal matrix/scavenger axis +- TopoLink-CCI_score: 0.747976 +- pyXenium rank: 2 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 11.234674798948532 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 2.588202246597835 +- `downstream_target_fdr`: 0.029131985731272295 +- `received_signal_target_spearman`: 0.6575063035069829 +- `cross_method_exact_count`: 5 +- `cross_method_same_lr_count`: 5 +- `bootstrap_rank_median`: 3.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/VWF_SELP_Endothelial_Cells_Endothelial_Cells.md b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/VWF_SELP_Endothelial_Cells_Endothelial_Cells.md new file mode 100644 index 0000000..d2c8399 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/reports/validation_cards/VWF_SELP_Endothelial_Cells_Endothelial_Cells.md @@ -0,0 +1,25 @@ +# VWF-SELP: Endothelial Cells -> Endothelial Cells + +- Biology label: WPB / endothelial activation +- TopoLink-CCI_score: 0.791289 +- pyXenium rank: 1 +- Evidence class: strong +- Supported layers: 8/9 +- Interpretation: strong: 8/9 computational evidence layers support the axis; contamination_flag=False. + +## Key controls + +- `cell_label_perm_fdr`: 0.001996007984031936 +- `spatial_null_fdr`: 0.004651162790697674 +- `matched_gene_z`: 6.674917611699146 +- `matched_gene_percentile`: 1.0 +- `downstream_target_score`: 6.738417175908883 +- `downstream_target_fdr`: 0.027184466019417475 +- `received_signal_target_spearman`: 0.6283646829850982 +- `cross_method_exact_count`: 5 +- `cross_method_same_lr_count`: 5 +- `bootstrap_rank_median`: 1.0 +- `bootstrap_rank_iqr`: 0.0 +- `contamination_flag`: False + +This is computational support only; it does not prove protein-level binding or functional signaling. diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/run_summary.json b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/run_summary.json new file mode 100644 index 0000000..a197261 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/run_summary.json @@ -0,0 +1,15 @@ +{ + "status": "success", + "runtime_seconds": 70.934, + "n_scores": 1319600, + "n_target_axes": 7, + "evidence_class_counts": { + "strong": 7 + }, + "outputs": { + "evidence": "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_evidence.tsv", + "controls": "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_false_positive_controls.tsv", + "report": "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_validation_v2/reports/topolink_cci_validation_v2_report.md", + "figure": "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_validation_v2/figures/topolink_cci_validation_v2_evidence_matrix.png" + } +} \ No newline at end of file diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/bootstrap_stability_repeats.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/bootstrap_stability_repeats.tsv new file mode 100644 index 0000000..ec48a81 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/bootstrap_stability_repeats.tsv @@ -0,0 +1,36 @@ +axis_id bootstrap_id bootstrap_validation_score bootstrap_rank +VWF-SELP|Endothelial Cells->Endothelial Cells 1 2.5294846037115666 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 1 2.4775096018215743 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 1 2.492760816959846 2 +DLL4-NOTCH3|Endothelial Cells->Pericytes 1 1.6468683289549024 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 1 1.9733111259538318 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 1 1.9415515823178238 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 1 1.0242960341055216 7 +VWF-SELP|Endothelial Cells->Endothelial Cells 2 2.5171162335011186 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 2 2.473767032097854 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 2 2.4772141734693474 2 +DLL4-NOTCH3|Endothelial Cells->Pericytes 2 1.6386355219882283 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 2 1.9703233264062612 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 2 1.9142494261725485 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 2 1.0252292828485567 7 +VWF-SELP|Endothelial Cells->Endothelial Cells 3 2.5103975259149602 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 3 2.471284260537661 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 3 2.4798530594772266 2 +DLL4-NOTCH3|Endothelial Cells->Pericytes 3 1.6483774045144926 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 3 1.972576240962361 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 3 1.941759991358487 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 3 1.0218695412958279 7 +VWF-SELP|Endothelial Cells->Endothelial Cells 4 2.5250901302802897 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 4 2.476756834260751 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 4 2.4928706890779577 2 +DLL4-NOTCH3|Endothelial Cells->Pericytes 4 1.6169876523117452 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 4 1.978781084743746 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 4 1.9076236376944962 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 4 1.02607284368184 7 +VWF-SELP|Endothelial Cells->Endothelial Cells 5 2.541566594354046 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 5 2.4811317184193578 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 5 2.473281442649322 3 +DLL4-NOTCH3|Endothelial Cells->Pericytes 5 1.6233431845634525 6 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 5 1.9747722688717537 4 +CD48-CD2|T Lymphocytes->T Lymphocytes 5 1.921048420646914 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 5 1.025995534799094 7 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/bootstrap_stability_summary.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/bootstrap_stability_summary.tsv new file mode 100644 index 0000000..7ba975b --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/bootstrap_stability_summary.tsv @@ -0,0 +1,8 @@ +axis_id bootstrap_rank_median bootstrap_rank_iqr bootstrap_score_mean bootstrap_score_sd bootstrap_n +CD48-CD2|T Lymphocytes->T Lymphocytes 5.0 0.0 1.925246611638054 0.015713655566381553 5 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 4.0 0.0 1.9739528093875909 0.0031410030934122366 5 +DLL4-NOTCH3|Endothelial Cells->Pericytes 6.0 0.0 1.634842418466564 0.014082178981952163 5 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 7.0 0.0 1.0246926473461682 0.0017333252101482156 5 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 2.0 0.0 2.48319603632674 0.009087646555426442 5 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 3.0 0.0 2.4760898894274397 0.003754003645322219 5 +VWF-SELP|Endothelial Cells->Endothelial Cells 1.0 0.0 2.5247310175523965 0.011933106345753796 5 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/cell_label_permutation.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/cell_label_permutation.tsv new file mode 100644 index 0000000..e4e88df --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/cell_label_permutation.tsv @@ -0,0 +1,8 @@ +axis_id cell_label_perm_status cell_label_comm_prob cell_label_perm_mean cell_label_perm_sd cell_label_perm_z cell_label_perm_p cell_label_perm_n cell_label_perm_fdr +VWF-SELP|Endothelial Cells->Endothelial Cells success 4.933703899383545 0.02757341218739748 0.002595310303671029 1890.383003626386 0.001996007984031936 500 0.001996007984031936 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 17.3447265625 0.2998358674645424 0.016262341095952152 1048.1203533037499 0.001996007984031936 500 0.001996007984031936 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 1.1805951595306396 0.008823287986218929 0.0006422116967277436 1824.588180992251 0.001996007984031936 500 0.001996007984031936 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 1.1344451904296875 0.022496088080108164 0.0018236492093399003 609.7384829575133 0.001996007984031936 500 0.001996007984031936 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 3.3160109519958496 0.08272893443703651 0.004327497961377857 747.1481318801938 0.001996007984031936 500 0.001996007984031936 +CD48-CD2|T Lymphocytes->T Lymphocytes success 0.2793356776237488 0.0026596546296495946 0.00022015248609680323 1256.7472114416275 0.001996007984031936 500 0.001996007984031936 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 2.0622618198394775 0.7131924320459366 0.005215585602508038 258.6611534368852 0.001996007984031936 500 0.001996007984031936 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/component_ablation.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/component_ablation.tsv new file mode 100644 index 0000000..3f55128 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/component_ablation.tsv @@ -0,0 +1,50 @@ +axis_id removed_component score_without_component rank_without_component +VWF-SELP|Endothelial Cells->Endothelial Cells sender_anchor 0.7972857392911651 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated sender_anchor 0.7536441590057466 4 +MMRN2-CD93|Endothelial Cells->Endothelial Cells sender_anchor 0.7125678529202889 14 +DLL4-NOTCH3|Endothelial Cells->Pericytes sender_anchor 0.6790747556139168 28 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes sender_anchor 0.6743531931310739 33 +CD48-CD2|T Lymphocytes->T Lymphocytes sender_anchor 0.6935160950384847 20 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells sender_anchor 0.6587434848395158 43 +VWF-SELP|Endothelial Cells->Endothelial Cells receiver_anchor 0.8080365281394246 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated receiver_anchor 0.7874256371615272 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells receiver_anchor 0.7257852420645114 10 +DLL4-NOTCH3|Endothelial Cells->Pericytes receiver_anchor 0.6836951692860163 27 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes receiver_anchor 0.6733001253395631 37 +CD48-CD2|T Lymphocytes->T Lymphocytes receiver_anchor 0.6976271933807175 20 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells receiver_anchor 0.6788097405077063 32 +VWF-SELP|Endothelial Cells->Endothelial Cells structure_bridge 0.7912892254406051 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated structure_bridge 0.7899855906874971 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells structure_bridge 0.710716588607183 16 +DLL4-NOTCH3|Endothelial Cells->Pericytes structure_bridge 0.6756766094906939 28 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes structure_bridge 0.7165895274301202 11 +CD48-CD2|T Lymphocytes->T Lymphocytes structure_bridge 0.6849876914223857 24 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells structure_bridge 0.6339180916556525 64 +VWF-SELP|Endothelial Cells->Endothelial Cells sender_expr 0.7912892254406051 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated sender_expr 0.7479758804762829 4 +MMRN2-CD93|Endothelial Cells->Endothelial Cells sender_expr 0.710716588607183 15 +DLL4-NOTCH3|Endothelial Cells->Pericytes sender_expr 0.6695148328230778 40 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes sender_expr 0.6616803560938078 46 +CD48-CD2|T Lymphocytes->T Lymphocytes sender_expr 0.6849876914223857 27 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells sender_expr 0.6339180916556525 74 +VWF-SELP|Endothelial Cells->Endothelial Cells receiver_expr 0.7912892254406051 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated receiver_expr 0.7479758804762829 3 +MMRN2-CD93|Endothelial Cells->Endothelial Cells receiver_expr 0.710716588607183 12 +DLL4-NOTCH3|Endothelial Cells->Pericytes receiver_expr 0.6855927184481351 25 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes receiver_expr 0.6616803560938078 47 +CD48-CD2|T Lymphocytes->T Lymphocytes receiver_expr 0.6849876914223857 26 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells receiver_expr 0.6339180916556525 82 +VWF-SELP|Endothelial Cells->Endothelial Cells local_contact 0.9719087998908531 13 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated local_contact 0.8926222806830125 566 +MMRN2-CD93|Endothelial Cells->Endothelial Cells local_contact 0.9766940588323647 9 +DLL4-NOTCH3|Endothelial Cells->Pericytes local_contact 0.9342339246883292 86 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes local_contact 0.890385654319548 708 +CD48-CD2|T Lymphocytes->T Lymphocytes local_contact 0.9698076148830775 16 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells local_contact 0.8986734151214785 387 +VWF-SELP|Endothelial Cells->Endothelial Cells prior_confidence 0.7912892254406051 1 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated prior_confidence 0.7479758804762829 2 +MMRN2-CD93|Endothelial Cells->Endothelial Cells prior_confidence 0.710716588607183 10 +DLL4-NOTCH3|Endothelial Cells->Pericytes prior_confidence 0.6695148328230778 24 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes prior_confidence 0.6616803560938078 28 +CD48-CD2|T Lymphocytes->T Lymphocytes prior_confidence 0.6849876914223857 16 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells prior_confidence 0.6339180916556525 45 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/contamination_controls.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/contamination_controls.tsv new file mode 100644 index 0000000..85ff31b --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/contamination_controls.tsv @@ -0,0 +1,8 @@ +axis_id contamination_marker_mean contamination_marker_detection contamination_marker_n endothelial_marker_mean endothelial_marker_detection endothelial_marker_n contamination_to_endothelial_ratio contamination_flag +VWF-SELP|Endothelial Cells->Endothelial Cells 0.05890538077801466 0.024628942486085346 5 2.5959966480731964 0.684963474025974 8 0.022690853943026265 False +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 0.026129559427499772 0.01609508256214843 5 0.717039417475462 0.20992484727514668 8 0.036440896819168185 False +MMRN2-CD93|Endothelial Cells->Endothelial Cells 0.05890538077801466 0.024628942486085346 5 2.5959966480731964 0.684963474025974 8 0.022690853943026265 False +DLL4-NOTCH3|Endothelial Cells->Pericytes 0.04168511740863323 0.01809586499910239 5 1.6176096498966217 0.4904778289749267 8 0.02576957760563387 False +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 0.01597042493522167 0.014516327788046826 5 0.060339648043736815 0.047238909426987066 8 0.2646754738053097 False +CD48-CD2|T Lymphocytes->T Lymphocytes 0.020254427567124367 0.018882514342728862 5 0.07943065511062741 0.06225056123721627 8 0.2549950965268374 False +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 0.013545505329966545 0.012730339184208883 5 0.05200395057909191 0.04524603348116684 8 0.26047069845906073 False diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/cross_method_support_detail.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/cross_method_support_detail.tsv new file mode 100644 index 0000000..4e94fb3 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/cross_method_support_detail.tsv @@ -0,0 +1,36 @@ +axis_id method exact_support same_lr_any_celltype_support same_sender_receiver_support exact_best_rank same_lr_best_rank same_lr_best_score_std artifact_path +VWF-SELP|Endothelial Cells->Endothelial Cells cellphonedb True True True 692.0 692.0 0.9994161168645052 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated cellphonedb True True True 2.0 2.0 0.99999915501717 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells cellphonedb True True True 1352.0 1352.0 0.9988584281967392 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes cellphonedb True True True 2869.0 2869.0 0.9975765892437064 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes cellphonedb True True True 171.0 171.0 0.9998563529189088 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes cellphonedb True True True 6381.0 6381.0 0.994609009544926 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cellphonedb True True True 2782.0 1232.0 0.9989598261363328 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells laris True True True 2845.0 2845.0 0.9978205811017408 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated laris True True True 18.0 18.0 0.9999869725311988 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells laris True True True 5577.0 5577.0 0.99572699023323 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes laris True True True 9878.0 9878.0 0.9924310406265446 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes laris True True True 226.0 226.0 0.9998275776188086 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes laris True True True 15762.0 15762.0 0.987922003777966 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells laris True True True 2153.0 889.0 0.9993195063355648 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells liana True True True 8450.0 1616.0 0.9978299106836924 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated liana True True True 58588.0 3227.0 0.9956651962016048 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells liana True True True 6324.0 3314.0 0.9955482935573206 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes liana True True True 81639.0 32868.0 0.955836330923168 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes liana True True True 69984.0 9542.0 0.9871796766768476 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes liana True True True 23050.0 23050.0 0.9690288615160526 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells liana True True True 1437.0 170.0 0.9997729132542068 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells spatialdm True True True 1967.0 1896.0 0.9957513401775244 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatialdm True True True 13686.0 13543.0 0.9696383370364308 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatialdm True True True 5602.0 5520.0 0.9876261986489486 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes spatialdm True True True 22202.0 22100.0 0.9504532277483448 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatialdm True True True 16101.0 16018.0 0.964089295843488 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes spatialdm True True True 4354.0 4221.0 0.9905386045114264 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatialdm True True True 9527.0 9527.0 0.9786423570084952 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/spatialdm/spatialdm_standardized.tsv.gz +VWF-SELP|Endothelial Cells->Endothelial Cells stlearn True True True 86660.0 86572.0 0.8286676126749274 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated stlearn True True True 111879.0 111727.0 0.7788834331787658 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +MMRN2-CD93|Endothelial Cells->Endothelial Cells stlearn True True True 114076.0 113983.0 0.7744185908435108 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +DLL4-NOTCH3|Endothelial Cells->Pericytes stlearn True True True 39734.0 39614.0 0.921602039261322 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes stlearn True True True 40249.0 40158.0 0.9205254106131044 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +CD48-CD2|T Lymphocytes->T Lymphocytes stlearn True True True 181555.0 181401.0 0.6409918441421705 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells stlearn True True True 36606.0 36606.0 0.9275551623749954 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/stlearn/stlearn_standardized.tsv.gz diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/downstream_target_support.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/downstream_target_support.tsv new file mode 100644 index 0000000..312a2bc --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/downstream_target_support.tsv @@ -0,0 +1,8 @@ +axis_id downstream_status downstream_target_genes_present downstream_target_score downstream_target_null_mean downstream_target_null_sd downstream_target_z downstream_target_p downstream_target_gene_panel downstream_target_fdr +VWF-SELP|Endothelial Cells->Endothelial Cells success 6 6.738417175908883 1.0064762527795716 1.4133941349379884 4.055444112466758 0.019417475728155338 VWF,SELP,ANGPT2,THBD,PLAT,SERPINE1 0.027184466019417475 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 7 2.588202246597835 0.41110825241499005 0.5784531172302644 3.763648132120292 0.02497027348394768 VWF,LRP1,HSPG2,COL4A1,COL4A2,MMP2,THBS2 0.029131985731272295 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 7 11.116392135620117 1.047396860657526 1.5327809936425985 6.56910238104792 0.0023781212841854932 MMRN2,CD93,CLEC14A,KDR,FLT1,PECAM1,EMCN 0.008323424494649227 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 8 2.61274266988039 0.5068325942343411 0.5551530740828993 3.7933863180438414 0.014568158168574402 DLL4,NOTCH3,NOTCH4,JAG1,HEY1,HES1,PDGFRB,RGS5 0.025494276795005204 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 8 6.800970241427422 1.15657870703144 1.2287697052997264 4.59353083824538 0.012486992715920915 CXCL12,CXCR4,CXCR3,CCL19,CCL21,CD3D,CD3E,IL7R 0.025494276795005204 +CD48-CD2|T Lymphocytes->T Lymphocytes success 7 11.544674396514893 1.0685981322434686 1.2195936012363278 8.589809141054532 0.0023781212841854932 CD48,CD2,CD3D,CD3E,TRAC,IL7R,LCK 0.008323424494649227 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 7 1.5110729336738586 1.5341725096816108 0.3373003415056495 -0.06848370180901593 0.6076099881093936 JAG1,NOTCH2,NOTCH1,HES1,HEY1,MYC,CCND1 0.6076099881093936 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/expression_gene_specificity.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/expression_gene_specificity.tsv new file mode 100644 index 0000000..e50665c --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/expression_gene_specificity.tsv @@ -0,0 +1,217 @@ +gene detected_in_wta top_celltype_rank cell_type mean_expr detection_fraction +ANGPT2 True 1.0 CAFs, Invasive Associated 0.07923019245188703 0.056235939264297485 +ANGPT2 True 2.0 Pericytes 0.07468777049585755 0.05440830811858177 +ANGPT2 True 3.0 Endothelial Cells 0.06064471243042672 0.0460343211889267 +ANGPT2 True 4.0 Mast Cells 0.02710027100271003 0.027100270614027977 +ANGPT2 True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.0231519090170593 0.01909017004072666 +CCL19 True 1.0 Pericytes 0.16520341288487697 0.053171757608652115 +CCL19 True 2.0 Endothelial Cells 0.0912569573283859 0.04359925910830498 +CCL19 True 3.0 T Lymphocytes 0.08605637316038912 0.05238214135169983 +CCL19 True 4.0 Dendritic Cells 0.07784431137724551 0.04241516813635826 +CCL19 True 5.0 B Cells 0.04856687898089172 0.029458599165081978 +CCL21 True 1.0 Endothelial Cells 0.02481447124304267 0.01982838660478592 +CCL21 True 2.0 Myeloid Cells 0.02214022140221402 0.019680196419358253 +CCL21 True 3.0 Pericytes 0.017559045381476443 0.013725732453167439 +CCL21 True 4.0 Apocrine Cells 0.01488833746898263 0.014888337813317776 +CCL21 True 5.0 Plasma Cells 0.012600229095074456 0.010309278033673763 +CCND1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 45.75142160844842 0.995938241481781 +CCND1 True 2.0 11q13 Invasive Tumor Cells (G1/S) 44.573715248525694 0.9978938698768616 +CCND1 True 3.0 11q13 Invasive Tumor Cells 35.123071397339 0.991645336151123 +CCND1 True 4.0 Basal-like Structured DCIS Cells 14.588698630136987 0.928196370601654 +CCND1 True 5.0 Luminal-like Amorphous DCIS Cells 5.254068160884249 0.8043444752693176 +CD2 True 1.0 T Lymphocytes 0.49837864804190574 0.3382389545440674 +CD2 True 2.0 B Cells 0.09156050955414012 0.07762739062309265 +CD2 True 3.0 Plasma Cells 0.07331042382588775 0.05154639109969139 +CD2 True 4.0 Dendritic Cells 0.060129740518962076 0.049151696264743805 +CD2 True 5.0 Mast Cells 0.04607046070460705 0.04065040498971939 +CD3D True 1.0 T Lymphocytes 0.7599151908206535 0.42105263471603394 +CD3D True 2.0 B Cells 0.1664012738853503 0.10748407989740372 +CD3D True 3.0 Plasma Cells 0.1111111111111111 0.07445590198040009 +CD3D True 4.0 Mast Cells 0.08401084010840108 0.056910570710897446 +CD3D True 5.0 Dendritic Cells 0.08383233532934131 0.057135727256536484 +CD3E True 1.0 T Lymphocytes 1.2775006235969069 0.6097530722618103 +CD3E True 2.0 B Cells 0.2929936305732484 0.20700636506080627 +CD3E True 3.0 Plasma Cells 0.1775486827033219 0.0996563583612442 +CD3E True 4.0 Dendritic Cells 0.12250499001996008 0.08283433318138123 +CD3E True 5.0 Mast Cells 0.056910569105691054 0.046070460230112076 +CD48 True 1.0 T Lymphocytes 0.5604888999750561 0.37989524006843567 +CD48 True 2.0 Dendritic Cells 0.5446606786427146 0.33582833409309387 +CD48 True 3.0 Plasma Cells 0.3104238258877434 0.2279496043920517 +CD48 True 4.0 Mast Cells 0.20596205962059622 0.16802167892456055 +CD48 True 5.0 B Cells 0.18431528662420382 0.14331209659576416 +CD63 False +CD93 True 1.0 Endothelial Cells 0.9689239332096475 0.5012755393981934 +CD93 True 2.0 Pericytes 0.23234821318164955 0.16285395622253418 +CD93 True 3.0 Dendritic Cells 0.2315369261477046 0.16017964482307434 +CD93 True 4.0 Macrophages 0.1983941983941984 0.139860138297081 +CD93 True 5.0 Mast Cells 0.08130081300813008 0.056910570710897446 +CLEC14A True 1.0 Endothelial Cells 1.3179499072356216 0.5895176529884338 +CLEC14A True 2.0 Pericytes 0.31643378261407196 0.20934833586215973 +CLEC14A True 3.0 Myeloid Cells 0.0959409594095941 0.084870845079422 +CLEC14A True 4.0 CAFs, Invasive Associated 0.07173206698325418 0.05373656749725342 +CLEC14A True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.06498781478472786 0.058489032089710236 +COL4A1 True 1.0 Endothelial Cells 2.700139146567718 0.6525974273681641 +COL4A1 True 2.0 CAFs, Invasive Associated 2.4473881529617594 0.6213446855545044 +COL4A1 True 3.0 Pericytes 1.5722764931371336 0.5163843035697937 +COL4A1 True 4.0 CAFs, DCIS Associated 0.6216348907618034 0.3171180784702301 +COL4A1 True 5.0 Myoepithelial Cells 0.40009480919649204 0.2188907265663147 +COL4A2 True 1.0 Endothelial Cells 1.5338589981447124 0.5666744112968445 +COL4A2 True 2.0 CAFs, Invasive Associated 1.4781304673831541 0.5351161956787109 +COL4A2 True 3.0 Pericytes 1.0337578830221343 0.4361320734024048 +COL4A2 True 4.0 CAFs, DCIS Associated 0.5452499795434089 0.33074215054512024 +COL4A2 True 5.0 Myoepithelial Cells 0.5319981038160702 0.31879591941833496 +CXCL12 True 1.0 CAFs, DCIS Associated 3.649660420587513 0.7872514724731445 +CXCL12 True 2.0 CAFs, Invasive Associated 1.556610847288178 0.4851287305355072 +CXCL12 True 3.0 Endothelial Cells 1.3608534322820036 0.47993969917297363 +CXCL12 True 4.0 Macrophages 1.0893550893550894 0.40663039684295654 +CXCL12 True 5.0 Pericytes 1.0134784221590207 0.37875601649284363 +CXCR3 True 1.0 T Lymphocytes 0.034048391119980044 0.03280119597911835 +CXCR3 True 2.0 Plasma Cells 0.014891179839633447 0.014891180209815502 +CXCR3 True 3.0 Dendritic Cells 0.011477045908183632 0.010479042306542397 +CXCR3 True 4.0 Myeloid Cells 0.008610086100861008 0.008610086515545845 +CXCR3 True 5.0 Mast Cells 0.008130081300813009 0.008130080997943878 +CXCR4 True 1.0 T Lymphocytes 0.9085806934397606 0.4825392961502075 +CXCR4 True 2.0 Dendritic Cells 0.6749001996007984 0.3540419042110443 +CXCR4 True 3.0 Plasma Cells 0.36769759450171824 0.21305841207504272 +CXCR4 True 4.0 B Cells 0.21934713375796178 0.1675955355167389 +CXCR4 True 5.0 Macrophages 0.1761201761201761 0.1339031308889389 +DLL4 True 1.0 Endothelial Cells 0.476461038961039 0.2467532455921173 +DLL4 True 2.0 Pericytes 0.10634351428218128 0.07703722268342972 +DLL4 True 3.0 Myeloid Cells 0.04551045510455105 0.03198032081127167 +DLL4 True 4.0 11q13 Invasive Tumor Cells (Mitotic) 0.038180341186027617 0.03452477604150772 +DLL4 True 5.0 Plasma Cells 0.020618556701030927 0.019473081454634666 +EMCN True 1.0 Endothelial Cells 1.4728664192949907 0.6341604590415955 +EMCN True 2.0 Pericytes 0.32274020032150363 0.21491281688213348 +EMCN True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.09057676685621446 0.07514216005802155 +EMCN True 4.0 Myeloid Cells 0.06888068880688807 0.05781057849526405 +EMCN True 5.0 Plasma Cells 0.06758304696449026 0.05841924250125885 +FLT1 True 1.0 Endothelial Cells 1.5473098330241188 0.6168830990791321 +FLT1 True 2.0 Pericytes 0.3560034623469766 0.23519228398799896 +FLT1 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.24654752233956134 0.20633630454540253 +FLT1 True 4.0 Myeloid Cells 0.21648216482164823 0.16851168870925903 +FLT1 True 5.0 Apocrine Cells 0.15632754342431762 0.14640198647975922 +HES1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 0.4435418359057677 0.307879775762558 +HES1 True 2.0 Luminal-like Amorphous DCIS Cells 0.40067546822229044 0.2689591646194458 +HES1 True 3.0 11q13 Invasive Tumor Cells (G1/S) 0.33403538331929233 0.24136479198932648 +HES1 True 4.0 11q13 Invasive Tumor Cells 0.2922418639515273 0.21926729381084442 +HES1 True 5.0 Basal-like Structured DCIS Cells 0.2264840182648402 0.1742009073495865 +HEY1 True 1.0 Endothelial Cells 0.24570964749536178 0.15584415197372437 +HEY1 True 2.0 11q13 Invasive Tumor Cells (Mitotic) 0.17749796913078797 0.1486596316099167 +HEY1 True 3.0 Basal-like Structured DCIS Cells 0.1430365296803653 0.10844749212265015 +HEY1 True 4.0 Myoepithelial Cells 0.1268073003081299 0.10630480945110321 +HEY1 True 5.0 Myeloid Cells 0.10947109471094711 0.08733087033033371 +HSPG2 True 1.0 Endothelial Cells 5.104359925788497 0.8711734414100647 +HSPG2 True 2.0 CAFs, Invasive Associated 2.2671832041989504 0.6923269033432007 +HSPG2 True 3.0 Pericytes 1.1843699765055027 0.48237913846969604 +HSPG2 True 4.0 CAFs, DCIS Associated 0.8459618689141641 0.4324932396411896 +HSPG2 True 5.0 Myoepithelial Cells 0.5875799952595402 0.3209291398525238 +IL7R True 1.0 T Lymphocytes 0.20990271888251436 0.15851832926273346 +IL7R True 2.0 Myeloid Cells 0.05289052890528905 0.046740468591451645 +IL7R True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.05280259951259139 0.05158407613635063 +IL7R True 4.0 Apocrine Cells 0.04714640198511166 0.04466501250863075 +IL7R True 5.0 Dendritic Cells 0.046656686626746505 0.037425149232149124 +JAG1 True 1.0 11q13 Invasive Tumor Cells (Mitotic) 1.9065800162469537 0.7083671689033508 +JAG1 True 2.0 11q13 Invasive Tumor Cells 1.4774345680554688 0.6293959617614746 +JAG1 True 3.0 11q13 Invasive Tumor Cells (G1/S) 1.3336141533277168 0.5867733955383301 +JAG1 True 4.0 Luminal-like Amorphous DCIS Cells 1.0723825606386246 0.5086736083030701 +JAG1 True 5.0 Basal-like Structured DCIS Cells 0.6257990867579909 0.3481735289096832 +KDR True 1.0 Endothelial Cells 2.37569573283859 0.6372912526130676 +KDR True 2.0 Pericytes 0.6527760603437616 0.3185359239578247 +KDR True 3.0 CAFs, Invasive Associated 0.10547363159210198 0.06723318994045258 +KDR True 4.0 Myeloid Cells 0.09471094710947109 0.084870845079422 +KDR True 5.0 Basal-like Structured DCIS Cells 0.08367579908675798 0.06061643734574318 +LCK True 1.0 T Lymphocytes 0.6152407084060864 0.3986031413078308 +LCK True 2.0 B Cells 0.11544585987261147 0.0927547737956047 +LCK True 3.0 Plasma Cells 0.08476517754868271 0.06643757224082947 +LCK True 4.0 Myeloid Cells 0.06150061500615006 0.05166051536798477 +LCK True 5.0 Dendritic Cells 0.058632734530938126 0.04466067999601364 +LRP1 True 1.0 CAFs, Invasive Associated 2.662834291427143 0.7233191728591919 +LRP1 True 2.0 CAFs, DCIS Associated 2.585713116766222 0.7374191880226135 +LRP1 True 3.0 Dendritic Cells 1.0197105788423153 0.44386228919029236 +LRP1 True 4.0 Macrophages 0.9233359233359233 0.440559446811676 +LRP1 True 5.0 Myoepithelial Cells 0.4869637354823418 0.302085816860199 +MMP2 True 1.0 CAFs, DCIS Associated 1.4687423287783323 0.5307257771492004 +MMP2 True 2.0 CAFs, Invasive Associated 1.3129217695576105 0.4966258406639099 +MMP2 True 3.0 Endothelial Cells 0.2912801484230056 0.1832096427679062 +MMP2 True 4.0 Dendritic Cells 0.2657185628742515 0.15668663382530212 +MMP2 True 5.0 Myoepithelial Cells 0.2623844512917753 0.1821521669626236 +MMRN2 True 1.0 Endothelial Cells 1.2184601113172542 0.5637755393981934 +MMRN2 True 2.0 Pericytes 0.2594287127488562 0.17744527757167816 +MMRN2 True 3.0 Basal-like Structured DCIS Cells 0.06746575342465753 0.05319634824991226 +MMRN2 True 4.0 Myoepithelial Cells 0.06245555818914435 0.05131547898054123 +MMRN2 True 5.0 Mast Cells 0.04607046070460705 0.0379403792321682 +MYC True 1.0 Basal-like Structured DCIS Cells 1.5598173515981735 0.5699771642684937 +MYC True 2.0 Endothelial Cells 1.1174628942486085 0.4582560360431671 +MYC True 3.0 11q13 Invasive Tumor Cells (G1/S) 0.9334456613310868 0.45408591628074646 +MYC True 4.0 11q13 Invasive Tumor Cells 0.8824879755137734 0.44670185446739197 +MYC True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.8273761169780666 0.43013811111450195 +NOTCH1 True 1.0 Endothelial Cells 0.5613404452690167 0.35366418957710266 +NOTCH1 True 2.0 Basal-like Structured DCIS Cells 0.4221461187214612 0.263812780380249 +NOTCH1 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.30381803411860275 0.22542648017406464 +NOTCH1 True 4.0 Pericytes 0.22517620873006058 0.15951527655124664 +NOTCH1 True 5.0 Myoepithelial Cells 0.2188907324010429 0.15868689119815826 +NOTCH2 True 1.0 Apocrine Cells 2.1861042183622827 0.7171216011047363 +NOTCH2 True 2.0 11q13 Invasive Tumor Cells 1.3958398400899494 0.607002317905426 +NOTCH2 True 3.0 11q13 Invasive Tumor Cells (Mitotic) 1.334281072298944 0.6255077123641968 +NOTCH2 True 4.0 Luminal-like Amorphous DCIS Cells 1.1538992938286767 0.5558028817176819 +NOTCH2 True 5.0 11q13 Invasive Tumor Cells (G1/S) 1.0602358887952823 0.5395956039428711 +NOTCH3 True 1.0 Pericytes 2.3809818226783728 0.5623840689659119 +NOTCH3 True 2.0 CAFs, Invasive Associated 1.1647088227943014 0.4973756670951843 +NOTCH3 True 3.0 Luminal-like Amorphous DCIS Cells 0.9322229045133559 0.4947804808616638 +NOTCH3 True 4.0 Endothelial Cells 0.7337662337662337 0.27516233921051025 +NOTCH3 True 5.0 Basal-like Structured DCIS Cells 0.6931506849315069 0.3960045576095581 +NOTCH4 True 1.0 Endothelial Cells 0.4457328385899815 0.28038033843040466 +NOTCH4 True 2.0 Myoepithelial Cells 0.10997866793078928 0.09042426943778992 +NOTCH4 True 3.0 Pericytes 0.08445653517991838 0.0650426596403122 +NOTCH4 True 4.0 Basal-like Structured DCIS Cells 0.07682648401826483 0.06255707889795303 +NOTCH4 True 5.0 11q13 Invasive Tumor Cells (Mitotic) 0.07636068237205523 0.06986190378665924 +PDGFRB True 1.0 CAFs, Invasive Associated 0.6135966008497875 0.3709072768688202 +PDGFRB True 2.0 Pericytes 0.42549771237789047 0.2529986500740051 +PDGFRB True 3.0 CAFs, DCIS Associated 0.32493249324932494 0.2368464171886444 +PDGFRB True 4.0 Endothelial Cells 0.15213358070500926 0.10227272659540176 +PDGFRB True 5.0 Dendritic Cells 0.05189620758483034 0.0416666679084301 +PECAM1 True 1.0 Endothelial Cells 4.5438311688311686 0.8918135166168213 +PECAM1 True 2.0 Plasma Cells 1.7445589919816724 0.6300114393234253 +PECAM1 True 3.0 Pericytes 1.0775318412266601 0.4703845679759979 +PECAM1 True 4.0 Dendritic Cells 0.7437624750499002 0.4149201512336731 +PECAM1 True 5.0 Macrophages 0.4421134421134421 0.28671327233314514 +PLAT True 1.0 11q13 Invasive Tumor Cells 8.869838840652132 0.956024706363678 +PLAT True 2.0 11q13 Invasive Tumor Cells (Mitotic) 7.280259951259139 0.9549146890640259 +PLAT True 3.0 11q13 Invasive Tumor Cells (G1/S) 6.233361415332772 0.9182813763618469 +PLAT True 4.0 Apocrine Cells 3.3101736972704714 0.8114144206047058 +PLAT True 5.0 Luminal-like Amorphous DCIS Cells 2.8183143997543754 0.6322535872459412 +RGS5 True 1.0 Pericytes 0.6418943984172129 0.3001112937927246 +RGS5 True 2.0 Endothelial Cells 0.5906771799628943 0.3025278151035309 +RGS5 True 3.0 CAFs, Invasive Associated 0.10747313171707074 0.06723318994045258 +RGS5 True 4.0 Myeloid Cells 0.07995079950799508 0.06519065052270889 +RGS5 True 5.0 Mast Cells 0.07859078590785908 0.0731707289814949 +SELP True 1.0 Endothelial Cells 0.7355055658627088 0.259508341550827 +SELP True 2.0 Pericytes 0.10980586125881044 0.07270928472280502 +SELP True 3.0 T Lymphocytes 0.06023946121227239 0.050511348992586136 +SELP True 4.0 Myeloid Cells 0.05166051660516605 0.04428044334053993 +SELP True 5.0 Plasma Cells 0.043528064146620846 0.03665521368384361 +SERPINE1 True 1.0 CAFs, Invasive Associated 0.3504123969007748 0.20569857954978943 +SERPINE1 True 2.0 Myoepithelial Cells 0.05724105238208106 0.03507940098643303 +SERPINE1 True 3.0 Endothelial Cells 0.05322356215213358 0.04012059420347214 +SERPINE1 True 4.0 CAFs, DCIS Associated 0.04107683495622289 0.03358972445130348 +SERPINE1 True 5.0 Dendritic Cells 0.036926147704590816 0.03168662637472153 +THBD True 1.0 Endothelial Cells 0.8287337662337663 0.40491652488708496 +THBD True 2.0 Pericytes 0.2860145913194015 0.18770866096019745 +THBD True 3.0 Dendritic Cells 0.1217564870259481 0.09356287121772766 +THBD True 4.0 CAFs, Invasive Associated 0.10847288177955511 0.0794801265001297 +THBD True 5.0 Myeloid Cells 0.08487084870848709 0.07503075152635574 +THBS2 True 1.0 CAFs, Invasive Associated 1.8375406148462885 0.5576105713844299 +THBS2 True 2.0 CAFs, DCIS Associated 1.6160297847966616 0.5173472166061401 +THBS2 True 3.0 Dendritic Cells 0.1317365269461078 0.071856290102005 +THBS2 True 4.0 CXCL14+ Fibroblasts 0.11588330632090761 0.07698541134595871 +THBS2 True 5.0 Pericytes 0.1151230369729195 0.07122542709112167 +TRAC True 1.0 T Lymphocytes 2.8600648540783236 0.7904714345932007 +TRAC True 2.0 B Cells 0.6871019108280255 0.3626592457294464 +TRAC True 3.0 Plasma Cells 0.33791523482245134 0.1477663218975067 +TRAC True 4.0 Dendritic Cells 0.24176646706586827 0.1230039894580841 +TRAC True 5.0 CAFs, Invasive Associated 0.15571107223194203 0.10172457247972488 +VWF True 1.0 Endothelial Cells 6.707908163265306 0.8781307935714722 +VWF True 2.0 Pericytes 1.29108445653518 0.4304439127445221 +VWF True 3.0 11q13 Invasive Tumor Cells (Mitotic) 0.11169780666125101 0.09423232823610306 +VWF True 4.0 Dendritic Cells 0.11052894211576847 0.05913173779845238 +VWF True 5.0 Mast Cells 0.10840108401084012 0.08130080997943878 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/functional_received_signal_support.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/functional_received_signal_support.tsv new file mode 100644 index 0000000..0345974 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/functional_received_signal_support.tsv @@ -0,0 +1,8 @@ +axis_id functional_signal_status received_signal_n_cells received_signal_target_spearman received_signal_target_p received_signal_top_vs_bottom_target_delta received_signal_target_fdr +VWF-SELP|Endothelial Cells->Endothelial Cells success 8624 0.6283646829850982 0.0 0.48874330520629883 0.0 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 24442 0.6575063035069829 0.0 0.5568488836288452 0.0 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 8624 0.4506380910061747 0.0 0.37315094470977783 0.0 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 8087 0.721750076253441 0.0 0.3684804439544678 0.0 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 8018 0.4955612441859473 0.0 0.19490374624729156 0.0 +CD48-CD2|T Lymphocytes->T Lymphocytes success 8018 0.4228849179250702 0.0 0.2631298005580902 0.0 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 64036 0.5874875426315861 0.0 0.44811439514160156 0.0 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/spatial_edge_summary.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/spatial_edge_summary.tsv new file mode 100644 index 0000000..6482437 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/spatial_edge_summary.tsv @@ -0,0 +1,8 @@ +axis_id edge_count mean_distance median_distance p90_distance +VWF-SELP|Endothelial Cells->Endothelial Cells 86240 76.043014780648 68.93717988356124 138.33223775288278 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated 86240 80.87535740094347 57.15353528817341 178.660086189941 +MMRN2-CD93|Endothelial Cells->Endothelial Cells 86240 76.043014780648 68.93717988356124 138.33223775288278 +DLL4-NOTCH3|Endothelial Cells->Pericytes 86240 84.10916634767867 78.14056887409708 151.5374911181689 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes 244420 164.70706693328117 146.09120882284316 307.8334754314995 +CD48-CD2|T Lymphocytes->T Lymphocytes 80180 61.10885372104814 33.60942094304036 154.61747704003622 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells 640360 18.888647018391925 17.47750226471102 28.465688513696342 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/spatial_neighborhood_controls.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/spatial_neighborhood_controls.tsv new file mode 100644 index 0000000..e2cb46f --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/spatial_neighborhood_controls.tsv @@ -0,0 +1,8 @@ +axis_id spatial_neighborhood_status spatial_edge_count spatial_edge_mean_distance spatial_lr_edge_score spatial_lr_active_edge_fraction spatial_perm_mean spatial_perm_sd spatial_perm_z spatial_perm_p spatial_matched_gene_mean spatial_matched_gene_sd spatial_matched_gene_z spatial_matched_gene_p spatial_null_fdr spatial_matched_gene_fdr +VWF-SELP|Endothelial Cells->Endothelial Cells success 86240 76.043014780648 7.3085808753967285 0.25011595547309834 5.2657176113128665 0.04370881998253159 46.73800996916185 0.0033222591362126247 0.018927508491591045 0.027477133079608154 265.29890675949275 0.008264462809917356 0.004651162790697674 0.009641873278236915 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated success 86240 80.87535740094347 17.646312713623047 0.6248144712430427 16.915456352233885 0.07295353245322052 10.01810792174873 0.0033222591362126247 0.09186524196557003 0.5419791132694604 32.389527643899775 0.008264462809917356 0.004651162790697674 0.009641873278236915 +MMRN2-CD93|Endothelial Cells->Endothelial Cells success 86240 76.043014780648 1.2517509460449219 0.29074675324675325 1.2041044370333354 0.00651539452823075 7.312912334799914 0.0033222591362126247 0.019798527385379808 0.041071614915599616 29.99522714631871 0.008264462809917356 0.004651162790697674 0.009641873278236915 +DLL4-NOTCH3|Endothelial Cells->Pericytes success 86240 84.10916634767867 1.1946196556091309 0.14225417439703153 1.1400103183587391 0.011914708983071235 4.58335468604246 0.0033222591362126247 0.010454062237477047 0.01560259723839002 75.89541505679755 0.008264462809917356 0.004651162790697674 0.009641873278236915 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes success 244420 164.70706693328117 3.6240406036376953 0.3872269045086327 3.6269676375389097 0.011749306634564156 -0.24912396895010336 0.5813953488372093 0.017585406292346305 0.025217267011605142 143.01530755436883 0.008264462809917356 0.5813953488372093 0.009641873278236915 +CD48-CD2|T Lymphocytes->T Lymphocytes success 80180 61.10885372104814 0.2860439121723175 0.1294462459466201 0.27965914239486056 0.0026717226614147317 2.3897576906714106 0.009966777408637873 0.004725929109872596 0.017223321423744452 16.333550082541787 0.008264462809917356 0.011627906976744186 0.009641873278236915 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells success 640360 18.888647018391925 2.253023386001587 0.39369885689299766 2.055801842212677 0.0037028198352934225 53.26252763072426 0.0033222591362126247 1.8470757191379865 0.5534657573718224 0.7334648285944125 0.2066115702479339 0.004651162790697674 0.2066115702479339 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_evidence.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_evidence.tsv new file mode 100644 index 0000000..4e4310d --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_evidence.tsv @@ -0,0 +1,15 @@ +axis_id biology_label ligand receptor sender receiver CCI_score pyxenium_rank sender_anchor receiver_anchor structure_bridge sender_expr receiver_expr local_contact_x prior_confidence cross_edge_count sender_expr_label receiver_expr_label ligand_sender_mean ligand_sender_detection_fraction ligand_sender_celltype_rank ligand_sender_specificity_ratio receptor_receiver_mean receptor_receiver_detection_fraction receptor_receiver_celltype_rank receptor_receiver_specificity_ratio observed_cross_edge_count expected_cross_edge_count_abundance_null cross_edge_enrichment_fold cross_edge_enrichment_z cross_edge_enrichment_p_approx local_contact_y contact_coverage within_sender_receiver_rank within_sender_receiver_n within_sender_receiver_percentile within_lr_pair_rank within_lr_pair_n within_lr_pair_percentile matched_gene_status n_controls observed_expression_specificity_score control_mean control_sd matched_gene_z matched_gene_percentile max_rank_after_ablation min_rank_after_ablation cross_method_exact_count cross_method_same_lr_count cross_method_same_sender_receiver_count supporting_methods_exact supporting_methods_same_lr target_panel_present_n receiver_context_panel_score receiver_context_panel_genes cell_label_perm_status cell_label_comm_prob cell_label_perm_mean cell_label_perm_sd cell_label_perm_z cell_label_perm_p cell_label_perm_n cell_label_perm_fdr spatial_neighborhood_status spatial_edge_count spatial_edge_mean_distance spatial_lr_edge_score spatial_lr_active_edge_fraction spatial_perm_mean spatial_perm_sd spatial_perm_z spatial_perm_p spatial_matched_gene_mean spatial_matched_gene_sd spatial_matched_gene_z spatial_matched_gene_p spatial_null_fdr spatial_matched_gene_fdr downstream_status downstream_target_genes_present downstream_target_score downstream_target_null_mean downstream_target_null_sd downstream_target_z downstream_target_p downstream_target_gene_panel downstream_target_fdr functional_signal_status received_signal_n_cells received_signal_target_spearman received_signal_target_p received_signal_top_vs_bottom_target_delta received_signal_target_fdr contamination_marker_mean contamination_marker_detection contamination_marker_n endothelial_marker_mean endothelial_marker_detection endothelial_marker_n contamination_to_endothelial_ratio contamination_flag bootstrap_rank_median bootstrap_rank_iqr bootstrap_score_mean bootstrap_score_sd bootstrap_n expression_specificity_support cell_label_permutation_support spatial_null_support matched_gene_control_support downstream_target_support functional_received_signal_support cross_method_support component_ablation_support bootstrap_stability_support support_count evidence_class interpretation_note axis_label +VWF-SELP|Endothelial Cells->Endothelial Cells WPB / endothelial activation VWF SELP Endothelial Cells Endothelial Cells 0.7912892368005828 1 0.955713094717548 0.8819126042133903 1.0 1.0 1.0 0.2912449657481761 1.0 12779 Endothelial Cells Endothelial Cells 6.707908163265306 0.8781307935714722 1 1.0 0.7355055658627088 0.259508341550827 1 1.0 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.2912449657481761 0.1111198059316065 1 3299 1.0 1 400 1.0 success 250 0.690919789894645 0.1174789121765555 0.08590980609453787 6.674917611699146 1.0 13 1 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 6 0.6656207262750022 VWF,SELP,ANGPT2,THBD,PLAT,SERPINE1 success 4.933703899383545 0.02757341218739748 0.002595310303671029 1890.383003626386 0.001996007984031936 500 0.001996007984031936 success 86240 76.043014780648 7.3085808753967285 0.25011595547309834 5.2657176113128665 0.04370881998253159 46.73800996916185 0.0033222591362126247 0.018927508491591045 0.027477133079608154 265.29890675949275 0.008264462809917356 0.004651162790697674 0.009641873278236915 success 6 6.738417175908883 1.0064762527795716 1.4133941349379884 4.055444112466758 0.019417475728155338 VWF,SELP,ANGPT2,THBD,PLAT,SERPINE1 0.027184466019417475 success 8624 0.6283646829850982 0.0 0.48874330520629883 0.0 0.05890538077801466 0.024628942486085346 5 2.5959966480731964 0.684963474025974 8 0.022690853943026265 False 1.0 0.0 2.5247310175523965 0.011933106345753796 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "VWF-SELP +Endothelial Cells -> Endothelial Cells" +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated vascular-stromal matrix/scavenger axis VWF LRP1 Endothelial Cells CAFs, DCIS Associated 0.7479758913021439 2 0.955713094717548 0.7346293219749174 0.7204611100467462 1.0 1.0 0.3461937505325735 1.0 13942 Endothelial Cells CAFs, DCIS Associated 6.707908163265306 0.8781307935714722 1 1.0 2.585713116766222 0.7374191880226135 2 0.971037936942149 13942 9916.101448337911 1.4059961036740796 40.577088952341676 0.0 0.3461937505325735 0.1319036006311863 1 3299 1.0 1 400 1.0 success 250 0.8904867455342288 0.1132557384471686 0.06918144236447345 11.234674798948532 1.0 566 2 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 7 0.5161052675482147 VWF,LRP1,HSPG2,COL4A1,COL4A2,MMP2,THBS2 success 17.3447265625 0.2998358674645424 0.016262341095952152 1048.1203533037499 0.001996007984031936 500 0.001996007984031936 success 86240 80.87535740094347 17.646312713623047 0.6248144712430427 16.915456352233885 0.07295353245322052 10.01810792174873 0.0033222591362126247 0.09186524196557003 0.5419791132694604 32.389527643899775 0.008264462809917356 0.004651162790697674 0.009641873278236915 success 7 2.588202246597835 0.41110825241499005 0.5784531172302644 3.763648132120292 0.02497027348394768 VWF,LRP1,HSPG2,COL4A1,COL4A2,MMP2,THBS2 0.029131985731272295 success 24442 0.6575063035069829 0.0 0.5568488836288452 0.0 0.026129559427499772 0.01609508256214843 5 0.717039417475462 0.20992484727514668 8 0.036440896819168185 False 3.0 0.0 2.4760898894274397 0.003754003645322219 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "VWF-LRP1 +Endothelial Cells -> CAFs, DCIS Associated" +MMRN2-CD93|Endothelial Cells->Endothelial Cells CD93-MMRN2 angiogenesis MMRN2 CD93 Endothelial Cells Endothelial Cells 0.7107166026857937 10 0.9845127857250529 0.8817184225858201 1.0 1.0 1.0 0.1484661470807383 1.0 12779 Endothelial Cells Endothelial Cells 1.2184601113172542 0.5637755393981934 1 1.0 0.9689239332096475 0.5012755393981934 1 1.0 12779 3498.750466020217 3.652446816116025 157.09499064265975 0.0 0.1484661470807383 0.0288754988653259 5 3299 0.9987875113670809 1 400 1.0 success 250 0.7291144166273554 0.13022764647610297 0.09662146729412627 6.198278570208171 1.0 16 9 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 7 1.0 MMRN2,CD93,CLEC14A,KDR,FLT1,PECAM1,EMCN success 1.1805951595306396 0.008823287986218929 0.0006422116967277436 1824.588180992251 0.001996007984031936 500 0.001996007984031936 success 86240 76.043014780648 1.2517509460449219 0.29074675324675325 1.2041044370333354 0.00651539452823075 7.312912334799914 0.0033222591362126247 0.019798527385379808 0.041071614915599616 29.99522714631871 0.008264462809917356 0.004651162790697674 0.009641873278236915 success 7 11.116392135620117 1.047396860657526 1.5327809936425985 6.56910238104792 0.0023781212841854932 MMRN2,CD93,CLEC14A,KDR,FLT1,PECAM1,EMCN 0.008323424494649227 success 8624 0.4506380910061747 0.0 0.37315094470977783 0.0 0.05890538077801466 0.024628942486085346 5 2.5959966480731964 0.684963474025974 8 0.022690853943026265 False 2.0 0.0 2.48319603632674 0.009087646555426442 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "MMRN2-CD93 +Endothelial Cells -> Endothelial Cells" +CD48-CD2|T Lymphocytes->T Lymphocytes T-cell adhesion/co-stimulation CD48 CD2 T Lymphocytes T Lymphocytes 0.6849877065459009 16 0.928447473463448 0.8960994285623033 1.0 1.0 1.0 0.1241603897223811 1.0 21212 T Lymphocytes T Lymphocytes 0.5604888999750561 0.37989524006843567 1 1.0 0.49837864804190574 0.3382389545440674 1 1.0 21212 3024.318857794739 7.0138107115687145 331.09056328473696 0.0 0.1241603897223811 0.0154158023760135 1 3299 1.0 1 400 1.0 success 250 0.5987173848132842 0.10702942070910819 0.04986335278579571 9.860708047779738 1.0 27 16 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 7 1.0 CD48,CD2,CD3D,CD3E,TRAC,IL7R,LCK success 0.2793356776237488 0.0026596546296495946 0.00022015248609680323 1256.7472114416275 0.001996007984031936 500 0.001996007984031936 success 80180 61.10885372104814 0.2860439121723175 0.1294462459466201 0.27965914239486056 0.0026717226614147317 2.3897576906714106 0.009966777408637873 0.004725929109872596 0.017223321423744452 16.333550082541787 0.008264462809917356 0.011627906976744186 0.009641873278236915 success 7 11.544674396514893 1.0685981322434686 1.2195936012363278 8.589809141054532 0.0023781212841854932 CD48,CD2,CD3D,CD3E,TRAC,IL7R,LCK 0.008323424494649227 success 8018 0.4228849179250702 0.0 0.2631298005580902 0.0 0.020254427567124367 0.018882514342728862 5 0.07943065511062741 0.06225056123721627 8 0.2549950965268374 False 5.0 0.0 1.925246611638054 0.015713655566381553 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "CD48-CD2 +T Lymphocytes -> T Lymphocytes" +DLL4-NOTCH3|Endothelial Cells->Pericytes endothelial-pericyte Notch DLL4 NOTCH3 Endothelial Cells Pericytes 0.6695148471220083 24 0.9184503888425788 0.8818326005152037 0.946515890536252 1.0 0.8672894033034337 0.135465098207694 1.0 11379 Endothelial Cells Pericytes 0.476461038961039 0.2467532455921173 1 1.0 2.3809818226783728 0.5623840689659119 1 1.0 11379 3280.889960425034 3.4682662744732435 141.55074144031974 0.0 0.135465098207694 0.0303190087002372 1 3299 1.0 1 400 1.0 success 250 0.6103430039507179 0.10700066735274656 0.060629471265751134 8.301941713984622 1.0 86 24 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 8 0.48688694950414185 DLL4,NOTCH3,NOTCH4,JAG1,HEY1,HES1,PDGFRB,RGS5 success 1.1344451904296875 0.022496088080108164 0.0018236492093399003 609.7384829575133 0.001996007984031936 500 0.001996007984031936 success 86240 84.10916634767867 1.1946196556091309 0.14225417439703153 1.1400103183587391 0.011914708983071235 4.58335468604246 0.0033222591362126247 0.010454062237477047 0.01560259723839002 75.89541505679755 0.008264462809917356 0.004651162790697674 0.009641873278236915 success 8 2.61274266988039 0.5068325942343411 0.5551530740828993 3.7933863180438414 0.014568158168574402 DLL4,NOTCH3,NOTCH4,JAG1,HEY1,HES1,PDGFRB,RGS5 0.025494276795005204 success 8087 0.721750076253441 0.0 0.3684804439544678 0.0 0.04168511740863323 0.01809586499910239 5 1.6176096498966217 0.4904778289749267 8 0.02576957760563387 False 6.0 0.0 1.634842418466564 0.014082178981952163 5 True True True True True True True False True 8 strong strong: 8/9 computational evidence layers support the axis; contamination_flag=False. "DLL4-NOTCH3 +Endothelial Cells -> Pericytes" +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes CAF-immune chemokine recruitment CXCL12 CXCR4 CAFs, DCIS Associated T Lymphocytes 0.6616803690861207 28 0.8924110508951895 0.9008184599638702 0.6198216015396206 1.0 1.0 0.1684304172162009 1.0 11604 CAFs, DCIS Associated T Lymphocytes 3.649660420587513 0.7872514724731445 1 1.0 0.9085806934397606 0.4825392961502075 1 1.0 11604 9219.306750089676 1.258662968328625 24.92068208259856 2.220471678964988e-137 0.1684304172162009 0.0450706652878317 2 3299 0.9996968778417702 1 400 1.0 success 250 0.7850757124806441 0.1029738649850631 0.06079893118587669 11.218977606863426 1.0 708 11 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 8 0.7664489835769633 CXCL12,CXCR4,CXCR3,CCL19,CCL21,CD3D,CD3E,IL7R success 3.3160109519958496 0.08272893443703651 0.004327497961377857 747.1481318801938 0.001996007984031936 500 0.001996007984031936 success 244420 164.70706693328117 3.6240406036376953 0.3872269045086327 3.6269676375389097 0.011749306634564156 -0.24912396895010336 0.5813953488372093 0.017585406292346305 0.025217267011605142 143.01530755436883 0.008264462809917356 0.5813953488372093 0.009641873278236915 success 8 6.800970241427422 1.15657870703144 1.2287697052997264 4.59353083824538 0.012486992715920915 CXCL12,CXCR4,CXCR3,CCL19,CCL21,CD3D,CD3E,IL7R 0.025494276795005204 success 8018 0.4955612441859473 0.0 0.19490374624729156 0.0 0.01597042493522167 0.014516327788046826 5 0.060339648043736815 0.047238909426987066 8 0.2646754738053097 False 4.0 0.0 1.9739528093875909 0.0031410030934122366 5 True True False True True True True False True 7 strong strong: 7/9 computational evidence layers support the axis; contamination_flag=False. "CXCL12-CXCR4 +CAFs, DCIS Associated -> T Lymphocytes" +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells tumor-intrinsic Notch signaling JAG1 NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6339181063246662 45 0.7941469661104034 0.663300745568453 1.0 1.0 1.0 0.1231934200799743 1.0 423716 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 1.4774345680554688 0.6293959617614746 2 0.7749134866963281 1.3958398400899494 0.607002317905426 2 0.6385056249219633 423716 192905.1692550145 2.1964989410929725 567.2684147856648 0.0 0.1231934200799743 0.0168391092146626 10 3299 0.9972719005759321 1 400 1.0 success 250 0.6593758884575077 0.6351644259334726 0.07744275561402209 0.3126368933035661 0.576 387 32 5 5 5 cellphonedb,laris,liana,spatialdm,stlearn cellphonedb,laris,liana,spatialdm,stlearn 7 0.5860530033828537 JAG1,NOTCH2,NOTCH1,HES1,HEY1,MYC,CCND1 success 2.0622618198394775 0.7131924320459366 0.005215585602508038 258.6611534368852 0.001996007984031936 500 0.001996007984031936 success 640360 18.888647018391925 2.253023386001587 0.39369885689299766 2.055801842212677 0.0037028198352934225 53.26252763072426 0.0033222591362126247 1.8470757191379865 0.5534657573718224 0.7334648285944125 0.2066115702479339 0.004651162790697674 0.2066115702479339 success 7 1.5110729336738586 1.5341725096816108 0.3373003415056495 -0.06848370180901593 0.6076099881093936 JAG1,NOTCH2,NOTCH1,HES1,HEY1,MYC,CCND1 0.6076099881093936 success 64036 0.5874875426315861 0.0 0.44811439514160156 0.0 0.013545505329966545 0.012730339184208883 5 0.05200395057909191 0.04524603348116684 8 0.26047069845906073 False 7.0 0.0 1.0246926473461682 0.0017333252101482156 5 True True True False False True True False True 6 strong strong: 6/9 computational evidence layers support the axis; contamination_flag=False. "JAG1-NOTCH2 +11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells" diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_false_positive_controls.tsv b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_false_positive_controls.tsv new file mode 100644 index 0000000..d5424d9 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_false_positive_controls.tsv @@ -0,0 +1,78 @@ +axis_id control_type observed expected_or_control_mean z_or_rank p_or_percentile note cell_label_comm_prob cell_label_perm_mean cell_label_perm_z cell_label_perm_p cell_label_perm_fdr spatial_lr_edge_score spatial_perm_mean spatial_perm_z spatial_perm_p spatial_null_fdr spatial_matched_gene_mean spatial_matched_gene_z spatial_matched_gene_p spatial_matched_gene_fdr downstream_target_score downstream_target_null_mean downstream_target_z downstream_target_p downstream_target_fdr received_signal_target_spearman received_signal_target_p received_signal_target_fdr received_signal_top_vs_bottom_target_delta bootstrap_rank_median bootstrap_rank_iqr bootstrap_score_mean bootstrap_score_sd +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-SELP|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_abundance_null 13942.0 9916.101448337911 40.577088952341676 0.0 cell-type-label abundance null for graph edge count +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_abundance_null 12779.0 3498.750466020217 157.09499064265975 0.0 cell-type-label abundance null for graph edge count +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_sender_receiver 5.0 3299.0 5.0 0.9987875113670809 rank percentile against all LR pairs in the same sender-receiver cell-type pair +MMRN2-CD93|Endothelial Cells->Endothelial Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_abundance_null 11379.0 3280.889960425034 141.55074144031974 0.0 cell-type-label abundance null for graph edge count +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +DLL4-NOTCH3|Endothelial Cells->Pericytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_abundance_null 11604.0 9219.306750089676 24.92068208259856 2.220471678964988e-137 cell-type-label abundance null for graph edge count +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_sender_receiver 2.0 3299.0 2.0 0.9996968778417702 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_abundance_null 21212.0 3024.318857794739 331.09056328473696 0.0 cell-type-label abundance null for graph edge count +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_sender_receiver 1.0 3299.0 1.0 1.0 rank percentile against all LR pairs in the same sender-receiver cell-type pair +CD48-CD2|T Lymphocytes->T Lymphocytes lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_abundance_null 423716.0 192905.1692550145 567.2684147856648 0.0 cell-type-label abundance null for graph edge count +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_sender_receiver 10.0 3299.0 10.0 0.9972719005759321 rank percentile against all LR pairs in the same sender-receiver cell-type pair +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells lr_label_permutation_same_lr_pair 1.0 400.0 1.0 1.0 rank percentile for the same LR pair across cell-type pairs +VWF-SELP|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.690919789894645 0.1174789121765555 6.674917611699146 1.0 matched by global mean expression and detection fraction +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated matched_gene_expression_control 0.8904867455342288 0.1132557384471686 11.234674798948532 1.0 matched by global mean expression and detection fraction +MMRN2-CD93|Endothelial Cells->Endothelial Cells matched_gene_expression_control 0.7291144166273554 0.13022764647610297 6.198278570208171 1.0 matched by global mean expression and detection fraction +DLL4-NOTCH3|Endothelial Cells->Pericytes matched_gene_expression_control 0.6103430039507179 0.10700066735274656 8.301941713984622 1.0 matched by global mean expression and detection fraction +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes matched_gene_expression_control 0.7850757124806441 0.1029738649850631 11.218977606863426 1.0 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes matched_gene_expression_control 0.5987173848132842 0.10702942070910819 9.860708047779738 1.0 matched by global mean expression and detection fraction +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells matched_gene_expression_control 0.6593758884575077 0.6351644259334726 0.3126368933035661 0.576 matched by global mean expression and detection fraction +CD48-CD2|T Lymphocytes->T Lymphocytes component_ablation_max_rank 27.0 16.0 27.0 worst and best rank after removing one score component +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes component_ablation_max_rank 708.0 11.0 708.0 worst and best rank after removing one score component +DLL4-NOTCH3|Endothelial Cells->Pericytes component_ablation_max_rank 86.0 24.0 86.0 worst and best rank after removing one score component +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells component_ablation_max_rank 387.0 32.0 387.0 worst and best rank after removing one score component +MMRN2-CD93|Endothelial Cells->Endothelial Cells component_ablation_max_rank 16.0 9.0 16.0 worst and best rank after removing one score component +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated component_ablation_max_rank 566.0 2.0 566.0 worst and best rank after removing one score component +VWF-SELP|Endothelial Cells->Endothelial Cells component_ablation_max_rank 13.0 1.0 13.0 worst and best rank after removing one score component +VWF-SELP|Endothelial Cells->Endothelial Cells cell_label_permutation 4.933703899383545 0.02757341218739748 1890.383003626386 0.001996007984031936 0.001996007984031936 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated cell_label_permutation 17.3447265625 0.2998358674645424 1048.1203533037499 0.001996007984031936 0.001996007984031936 +MMRN2-CD93|Endothelial Cells->Endothelial Cells cell_label_permutation 1.1805951595306396 0.008823287986218929 1824.588180992251 0.001996007984031936 0.001996007984031936 +DLL4-NOTCH3|Endothelial Cells->Pericytes cell_label_permutation 1.1344451904296875 0.022496088080108164 609.7384829575133 0.001996007984031936 0.001996007984031936 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes cell_label_permutation 3.3160109519958496 0.08272893443703651 747.1481318801938 0.001996007984031936 0.001996007984031936 +CD48-CD2|T Lymphocytes->T Lymphocytes cell_label_permutation 0.2793356776237488 0.0026596546296495946 1256.7472114416275 0.001996007984031936 0.001996007984031936 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cell_label_permutation 2.0622618198394775 0.7131924320459366 258.6611534368852 0.001996007984031936 0.001996007984031936 +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_neighborhood_permutation 7.3085808753967285 5.2657176113128665 46.73800996916185 0.0033222591362126247 0.004651162790697674 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_neighborhood_permutation 17.646312713623047 16.915456352233885 10.01810792174873 0.0033222591362126247 0.004651162790697674 +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_neighborhood_permutation 1.2517509460449219 1.2041044370333354 7.312912334799914 0.0033222591362126247 0.004651162790697674 +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_neighborhood_permutation 1.1946196556091309 1.1400103183587391 4.58335468604246 0.0033222591362126247 0.004651162790697674 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_neighborhood_permutation 3.6240406036376953 3.6269676375389097 -0.24912396895010336 0.5813953488372093 0.5813953488372093 +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_neighborhood_permutation 0.2860439121723175 0.27965914239486056 2.3897576906714106 0.009966777408637873 0.011627906976744186 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_neighborhood_permutation 2.253023386001587 2.055801842212677 53.26252763072426 0.0033222591362126247 0.004651162790697674 +VWF-SELP|Endothelial Cells->Endothelial Cells spatial_matched_gene_pairs 7.3085808753967285 0.018927508491591045 265.29890675949275 0.008264462809917356 0.009641873278236915 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated spatial_matched_gene_pairs 17.646312713623047 0.09186524196557003 32.389527643899775 0.008264462809917356 0.009641873278236915 +MMRN2-CD93|Endothelial Cells->Endothelial Cells spatial_matched_gene_pairs 1.2517509460449219 0.019798527385379808 29.99522714631871 0.008264462809917356 0.009641873278236915 +DLL4-NOTCH3|Endothelial Cells->Pericytes spatial_matched_gene_pairs 1.1946196556091309 0.010454062237477047 75.89541505679755 0.008264462809917356 0.009641873278236915 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes spatial_matched_gene_pairs 3.6240406036376953 0.017585406292346305 143.01530755436883 0.008264462809917356 0.009641873278236915 +CD48-CD2|T Lymphocytes->T Lymphocytes spatial_matched_gene_pairs 0.2860439121723175 0.004725929109872596 16.333550082541787 0.008264462809917356 0.009641873278236915 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells spatial_matched_gene_pairs 2.253023386001587 1.8470757191379865 0.7334648285944125 0.2066115702479339 0.2066115702479339 +VWF-SELP|Endothelial Cells->Endothelial Cells downstream_target_enrichment 6.738417175908883 1.0064762527795716 4.055444112466758 0.019417475728155338 0.027184466019417475 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated downstream_target_enrichment 2.588202246597835 0.41110825241499005 3.763648132120292 0.02497027348394768 0.029131985731272295 +MMRN2-CD93|Endothelial Cells->Endothelial Cells downstream_target_enrichment 11.116392135620117 1.047396860657526 6.56910238104792 0.0023781212841854932 0.008323424494649227 +DLL4-NOTCH3|Endothelial Cells->Pericytes downstream_target_enrichment 2.61274266988039 0.5068325942343411 3.7933863180438414 0.014568158168574402 0.025494276795005204 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes downstream_target_enrichment 6.800970241427422 1.15657870703144 4.59353083824538 0.012486992715920915 0.025494276795005204 +CD48-CD2|T Lymphocytes->T Lymphocytes downstream_target_enrichment 11.544674396514893 1.0685981322434686 8.589809141054532 0.0023781212841854932 0.008323424494649227 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells downstream_target_enrichment 1.5110729336738586 1.5341725096816108 -0.06848370180901593 0.6076099881093936 0.6076099881093936 +VWF-SELP|Endothelial Cells->Endothelial Cells received_signal_target_correlation 0.6283646829850982 0.0 0.0 0.48874330520629883 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated received_signal_target_correlation 0.6575063035069829 0.0 0.0 0.5568488836288452 +MMRN2-CD93|Endothelial Cells->Endothelial Cells received_signal_target_correlation 0.4506380910061747 0.0 0.0 0.37315094470977783 +DLL4-NOTCH3|Endothelial Cells->Pericytes received_signal_target_correlation 0.721750076253441 0.0 0.0 0.3684804439544678 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes received_signal_target_correlation 0.4955612441859473 0.0 0.0 0.19490374624729156 +CD48-CD2|T Lymphocytes->T Lymphocytes received_signal_target_correlation 0.4228849179250702 0.0 0.0 0.2631298005580902 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells received_signal_target_correlation 0.5874875426315861 0.0 0.0 0.44811439514160156 +CD48-CD2|T Lymphocytes->T Lymphocytes bootstrap_stability 5.0 0.0 1.925246611638054 0.015713655566381553 +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes bootstrap_stability 4.0 0.0 1.9739528093875909 0.0031410030934122366 +DLL4-NOTCH3|Endothelial Cells->Pericytes bootstrap_stability 6.0 0.0 1.634842418466564 0.014082178981952163 +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells bootstrap_stability 7.0 0.0 1.0246926473461682 0.0017333252101482156 +MMRN2-CD93|Endothelial Cells->Endothelial Cells bootstrap_stability 2.0 0.0 2.48319603632674 0.009087646555426442 +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated bootstrap_stability 3.0 0.0 2.4760898894274397 0.003754003645322219 +VWF-SELP|Endothelial Cells->Endothelial Cells bootstrap_stability 1.0 0.0 2.5247310175523965 0.011933106345753796 diff --git a/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2_20102726.stderr.log b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2_20102726.stderr.log new file mode 100644 index 0000000..61d1924 --- /dev/null +++ b/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2_20102726.stderr.log @@ -0,0 +1,23 @@ + Command being timed: "/cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/envs/python/pyxenium/bin/python /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/repo/benchmarking/cci_2026_atera/scripts/topolink_cci_validation_v2.py --root /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04 --output-dir /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/validation/topolink_cci_validation_v2 --n-label-permutations 500 --n-spatial-permutations 300 --n-spatial-matched-pairs 120 --n-matched-controls 250 --n-downstream-permutations 120 --n-bootstraps 5 --k-neighbors 10 --seed 20260428" + User time (seconds): 82.11 + System time (seconds): 7.42 + Percent of CPU this job got: 91% + Elapsed (wall clock) time (h:mm:ss or m:ss): 1:38.10 + Average shared text size (kbytes): 0 + Average unshared data size (kbytes): 0 + Average stack size (kbytes): 0 + Average total size (kbytes): 0 + Maximum resident set size (kbytes): 8902180 + Average resident set size (kbytes): 0 + Major (requiring I/O) page faults: 4571 + Minor (reclaiming a frame) page faults: 651120 + Voluntary context switches: 17777 + Involuntary context switches: 474 + Swaps: 0 + File system inputs: 1917384 + File system outputs: 1136 + Socket messages sent: 0 + Socket messages received: 0 + Signals delivered: 0 + Page size (bytes): 4096 + Exit status: 0 diff --git a/benchmarking/cci_2026_atera/scripts/make_topolink_cci_validation_publication_figure.py b/benchmarking/cci_2026_atera/scripts/make_topolink_cci_validation_publication_figure.py new file mode 100644 index 0000000..0e1972c --- /dev/null +++ b/benchmarking/cci_2026_atera/scripts/make_topolink_cci_validation_publication_figure.py @@ -0,0 +1,717 @@ +from __future__ import annotations + +import argparse +import math +import textwrap +from pathlib import Path + +import matplotlib + +matplotlib.use("Agg") +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +from matplotlib import gridspec, patches +from matplotlib.backends.backend_pdf import PdfPages + + +DEFAULT_INPUT_DIR = Path( + r"D:/GitHub/pyXenium/benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2" +) +SUPPORT_COLS = [ + "expression_specificity_support", + "cell_label_permutation_support", + "spatial_null_support", + "matched_gene_control_support", + "downstream_target_support", + "functional_received_signal_support", + "cross_method_support", + "component_ablation_support", + "bootstrap_stability_support", +] +SUPPORT_LABELS = [ + "Expression\nspecificity", + "Label\npermutation", + "Spatial\nnull", + "Matched\ngenes", + "Downstream\ntargets", + "Received\nsignal", + "Cross-method\nconsensus", + "Component\nablation", + "Bootstrap\nstability", +] +EXPECTED_ORDER = [ + "VWF-SELP", + "VWF-LRP1", + "MMRN2-CD93", + "CD48-CD2", + "DLL4-NOTCH3", + "CXCL12-CXCR4", + "JAG1-NOTCH2", +] +BIOLOGY_COLORS = { + "WPB / endothelial activation": "#0f766e", + "vascular-stromal matrix/scavenger axis": "#2c7fb8", + "CD93-MMRN2 angiogenesis": "#41ab5d", + "T-cell adhesion/co-stimulation": "#31a354", + "endothelial-pericyte Notch": "#756bb1", + "CAF-immune chemokine recruitment": "#d95f0e", + "tumor-intrinsic Notch signaling": "#7f1d1d", +} + + +def as_bool(series: pd.Series) -> pd.Series: + return series.astype(str).str.lower().isin({"true", "1", "yes"}) + + +def neglog10(value: float) -> float: + if not np.isfinite(value) or value <= 0: + return np.nan + return -math.log10(max(value, 1e-300)) + + +def wrap(text: str, width: int = 26) -> str: + return "\n".join(textwrap.wrap(str(text), width=width, break_long_words=False)) + + +def load_tables(input_dir: Path) -> dict[str, pd.DataFrame]: + tables = input_dir / "tables" + required = { + "evidence": tables / "topolink_cci_validation_v2_evidence.tsv", + "cell_perm": tables / "cell_label_permutation.tsv", + "spatial": tables / "spatial_neighborhood_controls.tsv", + "matched": tables / "topolink_cci_validation_v2_false_positive_controls.tsv", + "downstream": tables / "downstream_target_support.tsv", + "bootstrap": tables / "bootstrap_stability_summary.tsv", + "ablation": tables / "component_ablation.tsv", + } + missing = [str(path) for path in required.values() if not path.exists()] + if missing: + raise FileNotFoundError("Missing validation table(s):\n" + "\n".join(missing)) + data = {name: pd.read_csv(path, sep="\t") for name, path in required.items()} + evidence = data["evidence"].copy() + evidence["lr_pair"] = evidence["ligand"].astype(str) + "-" + evidence["receptor"].astype(str) + evidence["axis_label_short"] = evidence["lr_pair"] + "\n" + evidence["sender"].astype(str) + " -> " + evidence["receiver"].astype(str) + for col in SUPPORT_COLS: + evidence[col] = as_bool(evidence[col]) + evidence = evidence.sort_values("pyxenium_rank", kind="mergesort").reset_index(drop=True) + data["evidence"] = evidence + return data + + +def validate_inputs(evidence: pd.DataFrame) -> None: + observed = evidence["lr_pair"].tolist() + if observed != EXPECTED_ORDER: + raise AssertionError(f"Unexpected LR order: {observed}") + top = evidence.iloc[0] + if top["lr_pair"] != "VWF-SELP" or int(top["pyxenium_rank"]) != 1 or round(float(top["CCI_score"]), 3) != 0.791: + raise AssertionError("VWF-SELP is not shown as rank 1 with CCI_score=0.791.") + support_sums = evidence[SUPPORT_COLS].sum(axis=1).astype(int) + if not np.array_equal(support_sums.to_numpy(), evidence["support_count"].astype(int).to_numpy()): + raise AssertionError("support_count does not match evidence matrix columns.") + cxcl = evidence.loc[evidence["lr_pair"] == "CXCL12-CXCR4"].iloc[0] + if bool(cxcl["spatial_null_support"]): + raise AssertionError("CXCL12-CXCR4 should remain spatial-null negative in the main figure.") + if int((evidence["evidence_class"] == "strong").sum()) != 7: + raise AssertionError("Expected 7 strong axes in PDC clean v2 results.") + + +def add_panel_label(ax: plt.Axes, label: str, title: str | None = None) -> None: + ax.text(-0.04, 1.05, label, transform=ax.transAxes, fontsize=13, weight="bold", va="bottom", ha="right") + if title: + ax.text(0.0, 1.05, title, transform=ax.transAxes, fontsize=10.5, weight="bold", va="bottom", ha="left") + + +def draw_panel_a(ax: plt.Axes) -> None: + ax.set_axis_off() + add_panel_label(ax, "A", "Classic LR/CCC false-positive controls applied to TopoLink-CCI discoveries") + steps = [ + ("pyXenium\nLR discovery", "#0f766e"), + ("7 classic\ncandidate axes", "#155e75"), + ("Orthogonal\nvalidation gates", "#1d4ed8"), + ("Evidence class\nstrong/moderate", "#166534"), + ] + x_positions = np.linspace(0.05, 0.92, len(steps)) + y = 0.55 + for i, ((text, color), x) in enumerate(zip(steps, x_positions)): + box = patches.FancyBboxPatch( + (x - 0.09, y - 0.13), + 0.18, + 0.26, + boxstyle="round,pad=0.018,rounding_size=0.025", + facecolor=color, + edgecolor="white", + linewidth=1.5, + transform=ax.transAxes, + ) + ax.add_patch(box) + ax.text(x, y, text, ha="center", va="center", fontsize=9.3, color="white", weight="bold", transform=ax.transAxes) + if i < len(steps) - 1: + ax.annotate( + "", + xy=(x_positions[i + 1] - 0.115, y), + xytext=(x + 0.11, y), + arrowprops=dict(arrowstyle="-|>", lw=1.6, color="#334155"), + xycoords=ax.transAxes, + textcoords=ax.transAxes, + ) + gates = [ + "label permutation", + "spatial null", + "matched genes", + "downstream targets", + "cross-method consensus", + "ablation + bootstrap", + ] + for i, gate in enumerate(gates): + x = 0.37 + (i % 3) * 0.16 + yy = 0.20 - (i // 3) * 0.12 + ax.scatter([x], [yy], s=95, color="#e0f2fe", edgecolor="#0369a1", transform=ax.transAxes, zorder=3) + ax.text(x + 0.025, yy, gate, ha="left", va="center", fontsize=8.2, color="#0f172a", transform=ax.transAxes) + ax.text( + 0.02, + 0.04, + "Principle: CCI_score nominates candidates; independent controls reduce false-positive risk.", + transform=ax.transAxes, + fontsize=8.4, + color="#475569", + ) + + +def draw_panel_b(ax: plt.Axes, evidence: pd.DataFrame) -> None: + add_panel_label(ax, "B", "Nine-layer evidence matrix") + mat = evidence[SUPPORT_COLS].to_numpy(dtype=float) + ax.imshow(np.ones_like(mat), cmap="Greys", vmin=0, vmax=1, alpha=0.08, aspect="auto") + for i, row in evidence.iterrows(): + color = BIOLOGY_COLORS.get(row["biology_label"], "#64748b") + for j, passed in enumerate(mat[i]): + face = "#0f766e" if passed else "#f8fafc" + edge = color if passed else "#cbd5e1" + ax.scatter(j, i, s=165, marker="o", facecolor=face, edgecolor=edge, linewidth=1.2, zorder=3) + if passed: + ax.text(j, i, "✓", ha="center", va="center", fontsize=8.2, color="white", weight="bold") + else: + ax.text(j, i, "–", ha="center", va="center", fontsize=9, color="#f59e0b", weight="bold") + ax.set_xticks(np.arange(len(SUPPORT_LABELS))) + ax.set_xticklabels(SUPPORT_LABELS, rotation=45, ha="right", fontsize=7.2) + ax.set_yticks(np.arange(len(evidence))) + ax.set_yticklabels(evidence["lr_pair"], fontsize=8.4) + ax.set_xlim(-0.7, len(SUPPORT_LABELS) - 0.3) + ax.set_ylim(len(evidence) - 0.4, -0.6) + ax.tick_params(length=0) + ax.spines[:].set_visible(False) + ax.text( + 0.98, + 1.05, + "7/7 strong; 0 artifact risk", + transform=ax.transAxes, + ha="right", + va="bottom", + fontsize=8.5, + color="#166534", + weight="bold", + ) + + +def draw_panel_c(ax: plt.Axes, evidence: pd.DataFrame) -> None: + add_panel_label(ax, "C", "Quantitative control strength") + metrics = [ + ("Label perm\n-log10 FDR", evidence["cell_label_perm_fdr"].map(neglog10), "cell_label_permutation_support"), + ("Spatial null\n-log10 FDR", evidence["spatial_null_fdr"].map(neglog10), "spatial_null_support"), + ("Matched\ngene z", pd.to_numeric(evidence["matched_gene_z"]), "matched_gene_control_support"), + ("Downstream\n-log10 FDR", evidence["downstream_target_fdr"].map(neglog10), "downstream_target_support"), + ] + y = np.arange(len(evidence)) + for j, (label, values, support_col) in enumerate(metrics): + vals = pd.to_numeric(values, errors="coerce").to_numpy(dtype=float) + finite = vals[np.isfinite(vals)] + vmax = np.nanmax(finite) if len(finite) else 1.0 + for i, val in enumerate(vals): + supported = bool(evidence.iloc[i][support_col]) + color = BIOLOGY_COLORS.get(evidence.iloc[i]["biology_label"], "#64748b") if supported else "#f59e0b" + size = 45 + 120 * min(max(val / max(vmax, 1e-9), 0), 1) if np.isfinite(val) else 45 + ax.scatter(j, i, s=size, color=color, edgecolor="white", linewidth=0.8, zorder=3, alpha=0.92) + text = f"{val:.1f}" if "z" in label else f"{val:.2f}" + ax.text(j + 0.13, i, text, va="center", ha="left", fontsize=6.8, color="#334155") + ax.set_xticks(np.arange(len(metrics))) + ax.set_xticklabels([m[0] for m in metrics], fontsize=7.5) + ax.set_yticks(y) + ax.set_yticklabels(evidence["lr_pair"], fontsize=8.1) + ax.set_xlim(-0.45, len(metrics) - 0.1) + ax.set_ylim(len(evidence) - 0.4, -0.6) + ax.grid(axis="y", color="#e2e8f0", linewidth=0.6) + ax.spines[["top", "right", "left"]].set_visible(False) + ax.tick_params(axis="y", length=0) + ax.text(1.06, 5, "spatial-null weak\nbut other layers strong", fontsize=6.8, color="#d97706", ha="left", va="center") + + +def draw_panel_d(ax: plt.Axes, evidence: pd.DataFrame) -> None: + add_panel_label(ax, "D", "Robustness and component ablation") + y = np.arange(len(evidence)) + boot = pd.to_numeric(evidence["bootstrap_rank_median"], errors="coerce").to_numpy(dtype=float) + iqr = pd.to_numeric(evidence["bootstrap_rank_iqr"], errors="coerce").to_numpy(dtype=float) + ablation = pd.to_numeric(evidence["max_rank_after_ablation"], errors="coerce").to_numpy(dtype=float) + ax.errorbar(boot, y - 0.14, xerr=np.vstack([iqr / 2, iqr / 2]), fmt="o", color="#0f766e", ecolor="#99f6e4", ms=5, label="Bootstrap median rank") + ax.scatter(ablation, y + 0.14, marker="^", s=48, color="#d97706", edgecolor="white", linewidth=0.7, label="Worst rank after ablation") + ax.axvline(750, color="#f59e0b", linestyle="--", linewidth=1.0, alpha=0.6) + ax.set_xscale("log") + ax.set_xlim(0.8, 1200) + ax.set_yticks(y) + ax.set_yticklabels(evidence["lr_pair"], fontsize=8.1) + ax.set_xlabel("Rank (lower is better; log scale)", fontsize=8.5) + ax.set_ylim(len(evidence) - 0.4, -0.6) + ax.grid(axis="x", color="#e2e8f0", linewidth=0.6) + ax.spines[["top", "right"]].set_visible(False) + ax.legend(loc="lower right", fontsize=7, frameon=False) + ax.text(1.02, 0, "VWF-SELP\nmedian rank 1", fontsize=6.9, color="#0f766e", va="center") + + +def draw_panel_e(ax: plt.Axes, evidence: pd.DataFrame) -> None: + ax.set_axis_off() + add_panel_label(ax, "E", "Biological axes retained after validation") + y0 = 0.93 + h = 0.12 + for i, row in evidence.iterrows(): + color = BIOLOGY_COLORS.get(row["biology_label"], "#64748b") + y = y0 - i * h + box = patches.FancyBboxPatch( + (0.02, y - 0.085), + 0.96, + 0.092, + boxstyle="round,pad=0.01,rounding_size=0.015", + facecolor="#ffffff", + edgecolor="#cbd5e1", + linewidth=0.8, + transform=ax.transAxes, + ) + ax.add_patch(box) + ax.add_patch(patches.Rectangle((0.025, y - 0.079), 0.014, 0.079, color=color, transform=ax.transAxes)) + ax.text(0.05, y - 0.018, row["lr_pair"], fontsize=8.4, weight="bold", color="#0f172a", transform=ax.transAxes, va="center") + ax.text(0.23, y - 0.018, wrap(row["biology_label"], 25), fontsize=6.9, color="#334155", transform=ax.transAxes, va="center") + ax.text( + 0.70, + y - 0.018, + f"rank {int(row['pyxenium_rank'])} | LR {float(row['CCI_score']):.3f} | {int(row['support_count'])}/9", + fontsize=7.0, + color="#0f172a", + transform=ax.transAxes, + va="center", + ) + ax.text( + 0.02, + 0.02, + "Computational validation; not protein-level or functional proof.", + fontsize=7.4, + color="#b45309", + transform=ax.transAxes, + ) + + +def make_main_figure(data: dict[str, pd.DataFrame], output_dir: Path) -> None: + evidence = data["evidence"] + fig = plt.figure(figsize=(11.8, 8.4), constrained_layout=False) + gs = gridspec.GridSpec(3, 2, figure=fig, height_ratios=[0.9, 1.7, 1.55], width_ratios=[1.35, 1.0], hspace=0.58, wspace=0.34) + ax_a = fig.add_subplot(gs[0, :]) + ax_b = fig.add_subplot(gs[1, 0]) + ax_c = fig.add_subplot(gs[1, 1]) + ax_d = fig.add_subplot(gs[2, 0]) + ax_e = fig.add_subplot(gs[2, 1]) + draw_panel_a(ax_a) + draw_panel_b(ax_b, evidence) + draw_panel_c(ax_c, evidence) + draw_panel_d(ax_d, evidence) + draw_panel_e(ax_e, evidence) + fig.suptitle( + "TopoLink-CCI discoveries pass multi-layer computational false-positive controls", + fontsize=14, + weight="bold", + y=0.985, + ) + output_dir.mkdir(parents=True, exist_ok=True) + fig.savefig(output_dir / "topolink_cci_validation_main_figure.png", dpi=300, bbox_inches="tight") + fig.savefig(output_dir / "topolink_cci_validation_main_figure.pdf", bbox_inches="tight") + fig.savefig(output_dir / "topolink_cci_validation_main_figure.svg", bbox_inches="tight") + plt.close(fig) + + +def draw_readable_panel_a(ax: plt.Axes) -> None: + ax.set_axis_off() + add_panel_label(ax, "A", "Validation concept: discovery is separated from credibility checks") + ax.text( + 0.02, + 0.78, + "pyXenium nominates LR axes", + fontsize=13, + weight="bold", + color="#0f766e", + transform=ax.transAxes, + ) + ax.text( + 0.02, + 0.58, + "CCI_score ranks candidate biology, but does not by itself prove cell-cell communication.", + fontsize=9.5, + color="#334155", + transform=ax.transAxes, + ) + ax.annotate( + "", + xy=(0.37, 0.67), + xytext=(0.29, 0.67), + arrowprops=dict(arrowstyle="-|>", lw=2.0, color="#475569"), + xycoords=ax.transAxes, + ) + ax.text( + 0.40, + 0.78, + "Independent false-positive controls", + fontsize=13, + weight="bold", + color="#1d4ed8", + transform=ax.transAxes, + ) + gate_groups = [ + ("Permutation", "Cell labels\ncommunication probability", "#dbeafe", "#1d4ed8"), + ("Spatial", "neighbor null\nmatched genes", "#dcfce7", "#166534"), + ("Biology", "downstream targets\nreceived signal", "#fef3c7", "#b45309"), + ("Consensus", "other methods\nbootstrap/ablation", "#ede9fe", "#6d28d9"), + ] + for i, (title, body, face, edge) in enumerate(gate_groups): + x = 0.40 + i * 0.145 + box = patches.FancyBboxPatch( + (x, 0.31), + 0.125, + 0.31, + boxstyle="round,pad=0.012,rounding_size=0.018", + facecolor=face, + edgecolor=edge, + linewidth=1.2, + transform=ax.transAxes, + ) + ax.add_patch(box) + ax.text(x + 0.0625, 0.53, title, ha="center", va="center", fontsize=9.1, weight="bold", color=edge, transform=ax.transAxes) + ax.text(x + 0.0625, 0.40, body, ha="center", va="center", fontsize=7.7, color="#334155", transform=ax.transAxes) + ax.annotate( + "", + xy=(0.94, 0.67), + xytext=(0.86, 0.67), + arrowprops=dict(arrowstyle="-|>", lw=2.0, color="#475569"), + xycoords=ax.transAxes, + ) + ax.text(0.965, 0.78, "Evidence class", ha="right", fontsize=13, weight="bold", color="#166534", transform=ax.transAxes) + ax.text(0.965, 0.58, "strong / moderate /\nhypothesis / artifact risk", ha="right", fontsize=9.0, color="#334155", transform=ax.transAxes) + ax.text( + 0.02, + 0.08, + "Main-message rule: a high LR axis is credible only when multiple orthogonal checks agree.", + fontsize=9.0, + color="#7c2d12", + transform=ax.transAxes, + bbox=dict(boxstyle="round,pad=0.3", facecolor="#fff7ed", edgecolor="#fed7aa"), + ) + + +def draw_readable_panel_b(ax: plt.Axes, evidence: pd.DataFrame) -> None: + ax.set_axis_off() + add_panel_label(ax, "B", "Seven classic LR axes pass the validation framework") + cols = [ + ("LR axis", 0.03), + ("Biology", 0.19), + ("Rank | CCI_score", 0.43), + ("Passed layers", 0.58), + ("Label", 0.71), + ("Spatial", 0.78), + ("Matched", 0.85), + ("Target", 0.92), + ("Notes", 0.98), + ] + for label, x in cols: + ax.text(x, 0.92, label, ha="right" if label == "Notes" else "left", va="center", fontsize=8.6, weight="bold", color="#0f172a", transform=ax.transAxes) + ax.plot([0.02, 0.985], [0.885, 0.885], color="#cbd5e1", lw=1.0, transform=ax.transAxes) + y_start = 0.80 + row_h = 0.105 + for i, row in evidence.iterrows(): + y = y_start - i * row_h + color = BIOLOGY_COLORS.get(row["biology_label"], "#64748b") + bg = "#f8fafc" if i % 2 == 0 else "#ffffff" + ax.add_patch( + patches.FancyBboxPatch( + (0.02, y - 0.045), + 0.965, + 0.078, + boxstyle="round,pad=0.004,rounding_size=0.008", + facecolor=bg, + edgecolor="#e2e8f0", + linewidth=0.6, + transform=ax.transAxes, + ) + ) + ax.add_patch(patches.Rectangle((0.024, y - 0.039), 0.010, 0.066, color=color, transform=ax.transAxes)) + ax.text(0.04, y, row["lr_pair"], ha="left", va="center", fontsize=9.0, weight="bold", color="#0f172a", transform=ax.transAxes) + ax.text(0.19, y, wrap(row["biology_label"], 29), ha="left", va="center", fontsize=7.2, color="#334155", transform=ax.transAxes) + ax.text(0.43, y, f"#{int(row['pyxenium_rank'])} | {float(row['CCI_score']):.3f}", ha="left", va="center", fontsize=8.1, color="#0f172a", transform=ax.transAxes) + ax.text(0.60, y, f"{int(row['support_count'])}/9 strong", ha="left", va="center", fontsize=8.1, color="#166534", weight="bold", transform=ax.transAxes) + compact_checks = [ + ("cell_label_permutation_support", 0.725), + ("spatial_null_support", 0.795), + ("matched_gene_control_support", 0.865), + ("downstream_target_support", 0.932), + ] + failed = [] + for col, x in compact_checks: + passed = bool(row[col]) + ax.scatter([x], [y], s=105, color="#0f766e" if passed else "#f59e0b", edgecolor="white", linewidth=0.8, transform=ax.transAxes, zorder=3) + ax.text(x, y, "✓" if passed else "–", ha="center", va="center", fontsize=7.6, color="white", weight="bold", transform=ax.transAxes) + if not passed: + failed.append(col) + note = "all key gates pass" + if row["lr_pair"] == "CXCL12-CXCR4": + note = "spatial-null weak" + if row["lr_pair"] == "JAG1-NOTCH2": + note = "target/matched weaker" + ax.text(0.98, y, note, ha="right", va="center", fontsize=7.2, color="#b45309" if failed else "#475569", transform=ax.transAxes) + ax.text( + 0.02, + 0.035, + "Shown checks are the most interpretable gates; full 9-layer evidence is in source data and supplementary figure.", + fontsize=7.6, + color="#64748b", + transform=ax.transAxes, + ) + + +def draw_readable_panel_c(ax: plt.Axes, evidence: pd.DataFrame) -> None: + ax.set_axis_off() + add_panel_label(ax, "C", "Take-home evidence") + left = ax.inset_axes([0.02, 0.12, 0.49, 0.76]) + right = ax.inset_axes([0.56, 0.12, 0.42, 0.76]) + + plot = evidence.sort_values("support_count", ascending=True) + y = np.arange(len(plot)) + colors = [BIOLOGY_COLORS.get(label, "#64748b") for label in plot["biology_label"]] + left.barh(y, plot["support_count"].astype(float), color=colors, alpha=0.92) + left.axvline(5, color="#334155", linestyle="--", lw=1.0) + left.text(5.05, len(plot) - 0.25, "strong threshold", fontsize=7.0, color="#334155", va="top") + left.set_yticks(y) + left.set_yticklabels(plot["lr_pair"], fontsize=8) + left.set_xlim(0, 9.5) + left.set_xlabel("Supported evidence layers (of 9)", fontsize=8.4) + left.set_title("All selected axes reach strong support", fontsize=9.2, weight="bold") + left.grid(axis="x", color="#e2e8f0", linewidth=0.6) + left.spines[["top", "right", "left"]].set_visible(False) + left.tick_params(axis="y", length=0) + + right.set_axis_off() + bullets = [ + ("Discovery", "Top axes remain biologically coherent after controls."), + ("Specificity", "Cell-label permutation FDR is significant for all 7 axes."), + ("Spatiality", "6/7 pass spatial-null; CXCL12-CXCR4 is retained by other evidence."), + ("Safety", "No platelet/RBC contamination flag in the selected axes."), + ("Caveat", "Computational support, not protein-level functional proof."), + ] + for i, (title, body) in enumerate(bullets): + yy = 0.90 - i * 0.18 + color = "#0f766e" if title != "Caveat" else "#b45309" + right.scatter([0.035], [yy], s=75, color=color, transform=right.transAxes) + right.text(0.085, yy + 0.025, title, fontsize=8.7, weight="bold", color="#0f172a", transform=right.transAxes, va="center") + right.text(0.085, yy - 0.045, wrap(body, 44), fontsize=7.4, color="#334155", transform=right.transAxes, va="center") + + +def make_readable_main_figure(data: dict[str, pd.DataFrame], output_dir: Path) -> None: + evidence = data["evidence"] + fig = plt.figure(figsize=(11.8, 9.2), constrained_layout=False) + gs = gridspec.GridSpec(3, 1, figure=fig, height_ratios=[1.05, 2.35, 1.55], hspace=0.32) + ax_a = fig.add_subplot(gs[0, 0]) + ax_b = fig.add_subplot(gs[1, 0]) + ax_c = fig.add_subplot(gs[2, 0]) + draw_readable_panel_a(ax_a) + draw_readable_panel_b(ax_b, evidence) + draw_readable_panel_c(ax_c, evidence) + fig.suptitle( + "Readable summary: TopoLink-CCI axes are supported by orthogonal computational controls", + fontsize=14.5, + weight="bold", + y=0.99, + ) + fig.savefig(output_dir / "topolink_cci_validation_main_figure_readable.png", dpi=300, bbox_inches="tight") + fig.savefig(output_dir / "topolink_cci_validation_main_figure_readable.pdf", bbox_inches="tight") + fig.savefig(output_dir / "topolink_cci_validation_main_figure_readable.svg", bbox_inches="tight") + plt.close(fig) + + +def write_readable_caption(data: dict[str, pd.DataFrame], output_dir: Path) -> None: + evidence = data["evidence"] + caption = f"""# Readable figure caption + +**Figure. Orthogonal computational controls support TopoLink-CCI discoveries.** +**A**, TopoLink-CCI scores are used to nominate candidate cell-cell interaction axes, which are then tested with independent control layers adapted from classic LR/CCC methods: permutation, spatial nulls, matched-gene controls, downstream/received-signal support, cross-method consensus, component ablation, and bootstrap stability. +**B**, Readable evidence table for seven biologically interpretable LR axes, ordered by pyXenium rank. The compact gates show label permutation, spatial null, matched-gene control, and downstream target support; full nine-layer support is included in source data. All seven axes are classified as strong. `CXCL12-CXCR4` is spatial-null weak but supported by other evidence layers; `JAG1-NOTCH2` has weaker matched-gene/downstream support but still meets the strong threshold. +**C**, Summary support counts and interpretive take-home points. The selected LR axes reach the pre-specified strong threshold of at least five independent computational evidence layers, and none are flagged for platelet/RBC contamination. + +This figure summarizes computational credibility only; it does not prove protein-level binding, secretion, or functional signaling. +""" + (output_dir / "figure_caption_readable.md").write_text(caption, encoding="utf-8") + + +def z_from_summary(observed: float, mean: float, sd: float) -> float: + if not all(np.isfinite([observed, mean, sd])) or sd <= 0: + return np.nan + return (observed - mean) / sd + + +def draw_null_summary_page(data: dict[str, pd.DataFrame]) -> plt.Figure: + evidence = data["evidence"] + cell = data["cell_perm"].set_index("axis_id") + spatial = data["spatial"].set_index("axis_id") + controls = data["matched"] + matched = controls[controls["control_type"] == "matched_gene_expression_control"].set_index("axis_id") + fig, axes = plt.subplots(len(evidence), 3, figsize=(9.2, 10.5), sharex=True, sharey=True) + x = np.linspace(-4, 4, 300) + y = np.exp(-(x**2) / 2) / math.sqrt(2 * math.pi) + for i, row in evidence.iterrows(): + axis_id = row["axis_id"] + z_values = [ + z_from_summary(cell.loc[axis_id, "cell_label_comm_prob"], cell.loc[axis_id, "cell_label_perm_mean"], cell.loc[axis_id, "cell_label_perm_sd"]) if axis_id in cell.index else np.nan, + z_from_summary(spatial.loc[axis_id, "spatial_lr_edge_score"], spatial.loc[axis_id, "spatial_perm_mean"], spatial.loc[axis_id, "spatial_perm_sd"]) if axis_id in spatial.index else np.nan, + float(matched.loc[axis_id, "z_or_rank"]) if axis_id in matched.index and pd.notna(matched.loc[axis_id, "z_or_rank"]) else np.nan, + ] + for j, (title, zval) in enumerate(zip(["Label perm", "Spatial perm", "Matched genes"], z_values)): + ax = axes[i, j] + ax.plot(x, y, color="#94a3b8", lw=1.0) + ax.fill_between(x, 0, y, color="#e2e8f0", alpha=0.8) + clipped = np.clip(zval, -4, 4) if np.isfinite(zval) else np.nan + if np.isfinite(clipped): + ax.axvline(clipped, color="#dc2626", lw=1.4) + label = f"z={zval:.1f}" if abs(zval) < 100 else "z>100" + ax.text(0.97, 0.75, label, transform=ax.transAxes, ha="right", va="center", fontsize=6.3, color="#991b1b") + if i == 0: + ax.set_title(title, fontsize=8.2) + if j == 0: + ax.set_ylabel(row["lr_pair"], fontsize=7.8, rotation=0, ha="right", va="center", labelpad=42) + ax.set_yticks([]) + ax.set_xticks([-4, 0, 4]) + ax.tick_params(labelsize=6.5, length=2) + ax.spines[["top", "right", "left"]].set_visible(False) + fig.suptitle("Supplementary Fig. S1: null summary distributions (observed red line; z-space)", fontsize=12, weight="bold", y=0.995) + fig.text(0.5, 0.015, "Standard deviations from saved null summaries; raw permutation draws were not retained.", ha="center", fontsize=7.2, color="#475569") + fig.tight_layout(rect=[0.05, 0.03, 1, 0.97]) + return fig + + +def draw_validation_card_page(evidence: pd.DataFrame) -> plt.Figure: + fig, axes = plt.subplots(4, 2, figsize=(9.2, 10.5)) + axes = axes.ravel() + for ax in axes: + ax.set_axis_off() + for i, row in evidence.iterrows(): + ax = axes[i] + color = BIOLOGY_COLORS.get(row["biology_label"], "#64748b") + card = patches.FancyBboxPatch((0.02, 0.06), 0.96, 0.86, boxstyle="round,pad=0.02,rounding_size=0.03", facecolor="#ffffff", edgecolor="#cbd5e1", transform=ax.transAxes) + ax.add_patch(card) + ax.add_patch(patches.Rectangle((0.02, 0.84), 0.96, 0.08, color=color, transform=ax.transAxes)) + ax.text(0.05, 0.88, row["lr_pair"], color="white", weight="bold", fontsize=10, transform=ax.transAxes, va="center") + ax.text(0.05, 0.77, f"{row['sender']} -> {row['receiver']}", fontsize=7.7, color="#334155", transform=ax.transAxes) + ax.text(0.05, 0.66, wrap(row["biology_label"], 32), fontsize=7.8, color="#0f172a", transform=ax.transAxes) + ax.text(0.05, 0.50, f"rank {int(row['pyxenium_rank'])} | CCI_score {float(row['CCI_score']):.3f}", fontsize=8.0, color="#0f172a", transform=ax.transAxes) + ax.text(0.05, 0.39, f"class: {row['evidence_class']} | support {int(row['support_count'])}/9", fontsize=8.0, color="#166534", transform=ax.transAxes, weight="bold") + failed = [label.replace("\n", " ") for label, col in zip(SUPPORT_LABELS, SUPPORT_COLS) if not bool(row[col])] + caveat = "No weak layer" if not failed else "Weak: " + ", ".join(failed) + ax.text(0.05, 0.25, wrap(caveat, 42), fontsize=7.1, color="#b45309" if failed else "#475569", transform=ax.transAxes) + ax.text(0.05, 0.12, "Computational support only.", fontsize=6.9, color="#64748b", transform=ax.transAxes) + fig.suptitle("Supplementary Fig. S2: per-axis validation cards", fontsize=12, weight="bold", y=0.985) + fig.tight_layout(rect=[0, 0, 1, 0.96]) + return fig + + +def make_supplementary_figures(data: dict[str, pd.DataFrame], output_dir: Path) -> None: + output_dir.mkdir(parents=True, exist_ok=True) + null_fig = draw_null_summary_page(data) + card_fig = draw_validation_card_page(data["evidence"]) + with PdfPages(output_dir / "topolink_cci_validation_supplementary_controls.pdf") as pdf: + pdf.savefig(null_fig, bbox_inches="tight") + pdf.savefig(card_fig, bbox_inches="tight") + null_fig.savefig(output_dir / "topolink_cci_validation_supplementary_null_summary.png", dpi=300, bbox_inches="tight") + card_fig.savefig(output_dir / "topolink_cci_validation_supplementary_cards.png", dpi=300, bbox_inches="tight") + plt.close(null_fig) + plt.close(card_fig) + + +def write_caption(data: dict[str, pd.DataFrame], output_dir: Path) -> None: + evidence = data["evidence"] + top = evidence.iloc[0] + caption = f"""# Figure caption + +**Figure. TopoLink-CCI discoveries pass multi-layer computational false-positive controls.** +**A**, Schematic of the validation framework. pyXenium nominates candidate cell-cell interaction axes, which are then evaluated with validation principles adapted from CellPhoneDB/Squidpy, CellChat, stLearn/SpatialDM, NicheNet, LIANA, and pyXenium-specific robustness checks. +**B**, Evidence matrix across seven biologically interpretable LR axes. Filled circles indicate evidence layers that passed the pre-specified thresholds. All seven axes were classified as strong and none were flagged as contamination/artifact risk. +**C**, Quantitative strength of selected controls: cell-label permutation FDR, spatial-null FDR, matched-gene z-score, and downstream target FDR. The top-ranked axis, {top['lr_pair']}, had CCI_score={float(top['CCI_score']):.3f}, label-permutation FDR={float(top['cell_label_perm_fdr']):.3g}, spatial-null FDR={float(top['spatial_null_fdr']):.3g}, and matched-gene z={float(top['matched_gene_z']):.2f}. +**D**, Bootstrap and component-ablation robustness. Bootstrap ranks are medians from five 80% stratified resamples; ablation shows the worst rank after removing one pyXenium score component at a time. +**E**, Biological interpretation cards for the retained LR axes. These results support computational credibility, but do not prove protein-level cell-cell interaction binding, secretion, or functional causality. + +Supplementary Fig. S1 visualizes saved null summaries in standardized z-space; raw permutation draws were not retained. Supplementary Fig. S2 shows per-axis validation cards and weak evidence layers. +""" + (output_dir / "figure_caption.md").write_text(caption, encoding="utf-8") + + +def write_source_data(data: dict[str, pd.DataFrame], output_dir: Path) -> None: + evidence = data["evidence"] + cols = [ + "lr_pair", + "sender", + "receiver", + "biology_label", + "CCI_score", + "pyxenium_rank", + "evidence_class", + "support_count", + "cell_label_perm_fdr", + "spatial_null_fdr", + "matched_gene_z", + "downstream_target_fdr", + "bootstrap_rank_median", + "bootstrap_rank_iqr", + "max_rank_after_ablation", + "contamination_flag", + *SUPPORT_COLS, + ] + evidence[cols].to_csv(output_dir / "topolink_cci_validation_publication_source_data.tsv", sep="\t", index=False) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description="Create publication figures for TopoLink-CCI validation v2.") + parser.add_argument("--input-dir", default=str(DEFAULT_INPUT_DIR), help="PDC clean validation v2 directory.") + parser.add_argument("--output-dir", default=None, help="Output directory. Defaults to INPUT_DIR/publication_figures.") + return parser.parse_args() + + +def main() -> None: + args = parse_args() + input_dir = Path(args.input_dir) + output_dir = Path(args.output_dir) if args.output_dir else input_dir / "publication_figures" + data = load_tables(input_dir) + validate_inputs(data["evidence"]) + make_main_figure(data, output_dir) + make_readable_main_figure(data, output_dir) + make_supplementary_figures(data, output_dir) + write_caption(data, output_dir) + write_readable_caption(data, output_dir) + write_source_data(data, output_dir) + expected = [ + "topolink_cci_validation_main_figure.png", + "topolink_cci_validation_main_figure.pdf", + "topolink_cci_validation_main_figure.svg", + "topolink_cci_validation_main_figure_readable.png", + "topolink_cci_validation_main_figure_readable.pdf", + "topolink_cci_validation_main_figure_readable.svg", + "topolink_cci_validation_supplementary_controls.pdf", + "figure_caption.md", + "figure_caption_readable.md", + ] + missing = [name for name in expected if not (output_dir / name).exists()] + if missing: + raise RuntimeError(f"Missing expected figure outputs: {missing}") + print(f"Wrote publication figures to {output_dir}") + + +if __name__ == "__main__": + main() diff --git a/benchmarking/cci_2026_atera/scripts/pdc/submit_pdc_matrix.py b/benchmarking/cci_2026_atera/scripts/pdc/submit_pdc_matrix.py index 16b1653..c559d07 100644 --- a/benchmarking/cci_2026_atera/scripts/pdc/submit_pdc_matrix.py +++ b/benchmarking/cci_2026_atera/scripts/pdc/submit_pdc_matrix.py @@ -32,6 +32,37 @@ "cellagentchat", "scild", ) +A100_AUTHORITATIVE_FULL_METHODS = ( + "pyxenium", + "squidpy", + "liana", + "spatialdm", + "stlearn", + "cellphonedb", + "laris", +) +PDC_FULL_BACKFILL_METHODS = tuple(method for method in ALL_METHODS if method not in A100_AUTHORITATIVE_FULL_METHODS) +PDC_REBUILD_FULL_METHODS = ("cellchat", "cellnest", "cellagentchat", "scild") +REBUILD_ENV_TAG = "rebuild_20260428" +SOURCE_PYTHON_REBUILD_METHODS = ("cellnest", "cellagentchat", "scild") +CELLAGENTCHAT_FULL_CHUNKS = 16 +PYXENIUM_PY310_RUNTIME_PIP = ( + "PyYAML>=6.0", + "click>=8.1", + "fsspec>=2024.6.0", + "pyarrow>=14,<18", + "aiohttp", + "shapely>=2.0", + "tifffile>=2024.8.10,<2026", + "imagecodecs>=2024.6.1,<2026", + "zarr>=2.16,<3", +) +SOURCE_CHECKOUTS = { + "cellchat": ("https://github.com/jinworks/CellChat.git", "75253cd0c9e68410e6e721a6d3a0419a1d7e358f"), + "cellnest": ("https://github.com/schwartzlab-methods/CellNEST.git", "2737fa8f54952b4b35a540f6070655a69f2c4999"), + "cellagentchat": ("https://github.com/mcgilldinglab/CellAgentChat.git", "37e51980cb9ba87684993d8bdae26feac8806bae"), + "scild": ("https://github.com/jiatingyu-amss/SCILD.git", "683515043df1878f3069c4dd5f887abb5c8976bd"), +} @dataclass(frozen=True) @@ -44,6 +75,7 @@ class MethodConfig: pip: tuple[str, ...] = () imports: tuple[str, ...] = () r_packages: tuple[str, ...] = () + bioc_packages: tuple[str, ...] = () github: tuple[str, ...] = () pdc_note: str = "" @@ -56,26 +88,39 @@ class MethodConfig: "laris": MethodConfig("python", "shared", 16, "192G", "18:00:00", pip=("laris",), imports=("laris",)), "cellphonedb": MethodConfig("python", "shared", 16, "160G", "12:00:00", pip=("cellphonedb",), imports=("cellphonedb",)), "stlearn": MethodConfig("python", "memory", 16, "300G", "18:00:00", pip=("stlearn",), imports=("stlearn",)), - "commot": MethodConfig("python", "memory", 16, "300G", "24:00:00", pip=("commot",), imports=("commot",)), + "commot": MethodConfig("python", "memory", 16, "300G", "24:00:00", pip=("numpy<2", "commot"), imports=("commot",)), "cellnest": MethodConfig( "python", "shared", 16, "160G", "12:00:00", - pip=("git+https://github.com/schwartzlab-methods/CellNEST.git",), - imports=("cellnest", "CellNEST"), - pdc_note="Dardel GPU is not NVIDIA/A100; run CPU/bounded adapter only unless ROCm support is confirmed.", + pip=(), + imports=("torch", "torch_geometric"), + pdc_note="Source-layout checkout at external_src/cellnest; prefer CellNEST Apptainer/Singularity image and fall back to a pinned Python env.", ), "cellagentchat": MethodConfig( "python", - "shared", - 16, - "160G", - "12:00:00", - pip=("git+https://github.com/mcgilldinglab/CellAgentChat.git",), - imports=("cellagentchat", "CellAgentChat"), - pdc_note="Dardel GPU is not NVIDIA/A100; run CPU/bounded adapter only unless ROCm support is confirmed.", + "memory", + 32, + "300G", + "24:00:00", + pip=( + "numpy==1.26.4", + "pandas>=1.5.0,<2.3", + "scipy>=1.9.1,<1.14", + "scanpy>=1.9.6,<1.11", + "anndata>=0.8.0,<0.11", + "zarr>=2.16,<3", + "Mesa==1.0.0", + "pyslingshot==0.0.2", + "sparselinear==0.0.5", + "torch>=1.13,<2.4", + "seaborn>=0.12", + "matplotlib>=3.6", + ), + imports=("preprocessor", "model_setup", "abm", "Communication"), + pdc_note="Source-layout checkout at external_src/cellagentchat; PYTHONPATH must include external_src/cellagentchat/src.", ), "scild": MethodConfig( "python", @@ -83,9 +128,30 @@ class MethodConfig: 16, "160G", "12:00:00", - pip=("git+https://github.com/jiatingyu-amss/SCILD.git",), - imports=("SCILD", "Models.SCILD_main"), - pdc_note="SCILD source layout may not be pip-installable; failure card is acceptable if import/API mapping fails.", + pip=( + "numpy==1.26.4", + "pandas>=2.0,<2.4", + "scipy==1.11.4", + "scanpy>=1.10,<1.12", + "anndata>=0.10,<0.12", + "zarr>=2.16,<3", + "commot==0.0.3", + "h5py>=3.10,<3.15", + "igraph>=0.11,<0.12", + "leidenalg>=0.10,<0.11", + "matplotlib>=3.8,<3.11", + "mpl-chord-diagram>=0.4,<0.5", + "networkx>=3.2,<3.5", + "plotly>=5.0,<6.0", + "scikit-image==0.22.0", + "scikit-learn>=1.4,<1.8", + "scikit-misc>=0.5,<0.6", + "torch>=2.1,<2.8", + "torch-geometric>=2.5,<2.7", + "tqdm>=4.66", + ), + imports=("Models.SCILD_main",), + pdc_note="Source-layout checkout at external_src/scild; PYTHONPATH must include external_src/scild.", ), "cellchat": MethodConfig( "r", @@ -94,6 +160,7 @@ class MethodConfig: "300G", "24:00:00", r_packages=("jsonlite", "Matrix", "data.table", "remotes", "future", "igraph", "NMF"), + bioc_packages=("BiocGenerics", "Biobase", "BiocNeighbors", "ComplexHeatmap"), github=("jinworks/CellChat",), ), "giotto": MethodConfig( @@ -158,42 +225,154 @@ def repo_root_from_script() -> Path: return Path(__file__).resolve().parents[4] +def rebuild_env_path(method: str, root: str) -> str: + return f"{root}/envs/{REBUILD_ENV_TAG}/{method}" + + +def source_checkout_command(method: str, root: str) -> str: + if method not in SOURCE_CHECKOUTS: + return "" + repo, commit = SOURCE_CHECKOUTS[method] + src = f"{root}/external_src/{method}" + return f""" +mkdir -p {q(root + "/external_src")} +if [ ! -d {q(src)}/.git ]; then + rm -rf {q(src)} + git clone {q(repo)} {q(src)} +fi +current_commit="$(git -C {q(src)} rev-parse HEAD 2>/dev/null || true)" +if [ "$current_commit" = {q(commit)} ]; then + echo "source_checkout_ok {method} already at {commit}" +else + if ! git -C {q(src)} cat-file -e {q(commit + "^{commit}")} 2>/dev/null; then + git -C {q(src)} fetch --all --tags --prune + fi + git -C {q(src)} checkout {q(commit)} +fi +""" + + +def python_module_load(method: str) -> str: + if method in SOURCE_PYTHON_REBUILD_METHODS: + return ( + "module load python/3.10 >/dev/null 2>&1 || " + "module load python/3.10.13 >/dev/null 2>&1 || " + "module load cray-python/3.10.10 >/dev/null 2>&1 || " + "module load python/3.12.3 >/dev/null 2>&1 || true" + ) + return "module load python/3.12.3 >/dev/null 2>&1 || true" + + +def pythonpath_for_method(method: str, root: str) -> str: + entries = [f"{root}/repo/src"] + if method == "cellagentchat": + entries.insert(0, f"{root}/external_src/cellagentchat/src") + elif method == "scild": + entries.insert(0, f"{root}/external_src/scild") + elif method == "cellnest": + entries.insert(0, f"{root}/external_src/cellnest") + return ":".join(entries) + ":${PYTHONPATH:-}" + + def python_env_setup(method: str, cfg: MethodConfig, root: str) -> str: - env = f"{root}/envs/python/{method}" + env = rebuild_env_path(method, root) if method in PDC_REBUILD_FULL_METHODS else f"{root}/envs/python/{method}" pip_packages = " ".join(q(pkg) for pkg in cfg.pip) + runtime_packages = " ".join(q(pkg) for pkg in PYXENIUM_PY310_RUNTIME_PIP) if method in SOURCE_PYTHON_REBUILD_METHODS else "" + repo_install = 'python -m pip install -e "$ROOT/repo" --no-deps' if method in SOURCE_PYTHON_REBUILD_METHODS else 'python -m pip install -e "$ROOT/repo"' import_checks = "\n".join( [ - "ok = False", f"for name in {list(cfg.imports)!r}:", " try:", " __import__(name)", " print(f'import_ok {name}')", - " ok = True", - " break", " except Exception as exc:", " print(f'import_failed {name}: {exc}')", - "if not ok:", - " raise SystemExit('no configured import succeeded')", + " raise", ] if cfg.imports else ["import pyXenium; print('import_ok pyXenium')"] ) + source_setup = source_checkout_command(method, root) + source_exports = "" + if method in SOURCE_PYTHON_REBUILD_METHODS: + source_exports = f""" +export {method.upper()}_SRC={q(root + "/external_src/" + method)} +export PYTHONPATH="{pythonpath_for_method(method, root)}" +""" + cellnest_bootstrap = "" + if method == "cellnest": + cellnest_bootstrap = f""" +CELLNEST_IMAGE="{env}/cellnest_image.sif" +if command -v apptainer >/dev/null 2>&1; then + if [ ! -s "$CELLNEST_IMAGE" ]; then apptainer pull "$CELLNEST_IMAGE" library://fatema/collection/cellnest_image.sif:latest || true; fi +elif command -v singularity >/dev/null 2>&1; then + if [ ! -s "$CELLNEST_IMAGE" ]; then singularity pull "$CELLNEST_IMAGE" library://fatema/collection/cellnest_image.sif:latest || true; fi +fi +if [ -s "$CELLNEST_IMAGE" ]; then + export CELLNEST_CONTAINER="$CELLNEST_IMAGE" +fi +""" + cellnest_fallback_pip = "" + if method == "cellnest": + cellnest_fallback_pip = """ +if [ ! -n "${CELLNEST_CONTAINER:-}" ]; then + python -m pip install numpy==1.26.4 pandas==2.2.1 scipy==1.12.0 anndata==0.10.6 scanpy==1.9.8 'zarr>=2.16,<3' qnorm==0.8.1 networkx==3.2.1 scikit-learn==1.4.1.post1 + python -m pip install torch torchvision torchaudio --index-url https://download.pytorch.org/whl/cpu || python -m pip install torch torchvision torchaudio + python -m pip install torch-geometric || true +fi +""" + import_checks = """ +import os +import shutil +import subprocess +container = os.environ.get("CELLNEST_CONTAINER") +runtime = shutil.which("apptainer") or shutil.which("singularity") +if container and runtime: + subprocess.check_call([runtime, "exec", container, "python", "-c", "import torch; print('cellnest_container_ok')"]) +else: + import torch + import torch_geometric + print("import_ok torch torch_geometric") +""" return f""" METHOD={q(method)} OUT="$ROOT/runs/env_audit/{method}" mkdir -p "$OUT" +rm -f "$OUT/method_card.md" "$OUT/run_summary.json" "$OUT/pip_freeze.txt" "$OUT/torch_wheel_tag.env" trap 'rc=$?; mkdir -p "$OUT"; printf "# %s PDC method card\\n\\n- Status: failed\\n- Stage: env_setup\\n- Exit code: %s\\n- Note: {cfg.pdc_note}\\n" "$METHOD" "$rc" > "$OUT/method_card.md"; exit "$rc"' ERR -module load python/3.12.3 >/dev/null 2>&1 || true +{source_setup} +{python_module_load(method)} PYTHON_BIN="$(command -v python3 || command -v python)" +if [ {str(method in PDC_REBUILD_FULL_METHODS).lower()} = true ]; then + rm -rf {q(env)} +fi if [ ! -x {q(env)}/bin/python ]; then "$PYTHON_BIN" -m venv {q(env)} fi . {q(env)}/bin/activate +{source_exports} python -m pip install --upgrade pip setuptools wheel -python -m pip install -e "$ROOT/repo" +{repo_install} +if [ -n {q(runtime_packages)} ]; then + python -m pip install {runtime_packages} +fi if [ -n {q(pip_packages)} ]; then python -m pip install {pip_packages} fi +if [ "$METHOD" = "cellagentchat" ]; then + python - <<'PY' > "$OUT/torch_wheel_tag.env" +import torch +base = torch.__version__.split("+", 1)[0] +cuda = torch.version.cuda +tag = "cpu" if not cuda else "cu" + cuda.replace(".", "") +print(f"TORCH_VERSION={{base}}") +print(f"TORCH_WHEEL_TAG={{tag}}") +PY + . "$OUT/torch_wheel_tag.env" + python -m pip install torch-scatter torch-sparse -f "https://data.pyg.org/whl/torch-${{TORCH_VERSION}}+${{TORCH_WHEEL_TAG}}.html" || python -m pip install torch-scatter torch-sparse +fi +{cellnest_bootstrap} +{cellnest_fallback_pip} python - <<'PY' {import_checks} PY @@ -203,72 +382,166 @@ def python_env_setup(method: str, cfg: MethodConfig, root: str) -> str: def r_env_setup(method: str, cfg: MethodConfig, root: str) -> str: - r_lib = f"{root}/envs/r_libs/{method}" + r_lib = f"{rebuild_env_path(method, root)}/Rlib" if method in PDC_REBUILD_FULL_METHODS else f"{root}/envs/r_libs/{method}" r_packages = ", ".join(repr(pkg) for pkg in cfg.r_packages) + bioc_packages = ", ".join(repr(pkg) for pkg in cfg.bioc_packages) github = ", ".join(repr(repo) for repo in cfg.github) + source_setup = source_checkout_command(method, root) + local_source = f"{root}/external_src/{method}" if method in SOURCE_CHECKOUTS else "" + r_preflight = ( + f"Rscript -e '.libPaths(c(Sys.getenv(\"R_LIBS_USER\"), .libPaths())); library(CellChat); library(NMF); sink(file.path(\"{r_lib}\", \"sessionInfo.txt\")); print(sessionInfo()); sink()'" + if method == "cellchat" + else f"Rscript -e '.libPaths(c(Sys.getenv(\"R_LIBS_USER\"), .libPaths())); sink(file.path(\"{r_lib}\", \"sessionInfo.txt\")); print(sessionInfo()); sink()'" + ) return f""" METHOD={q(method)} OUT="$ROOT/runs/env_audit/{method}" -mkdir -p "$OUT" {q(r_lib)} +mkdir -p "$OUT" +rm -f "$OUT/method_card.md" "$OUT/run_summary.json" trap 'rc=$?; mkdir -p "$OUT"; printf "# %s PDC method card\\n\\n- Status: failed\\n- Stage: r_env_setup\\n- Exit code: %s\\n" "$METHOD" "$rc" > "$OUT/method_card.md"; exit "$rc"' ERR +{source_setup} +module load libffi/3.4.2 >/dev/null 2>&1 || true module load cray-R/4.4.0 >/dev/null 2>&1 || true +if [ {str(method in PDC_REBUILD_FULL_METHODS).lower()} = true ]; then + rm -rf {q(rebuild_env_path(method, root))} +fi +mkdir -p {q(r_lib)} export R_LIBS_USER={q(r_lib)} Rscript - <<'RS' repos <- c(CRAN = "https://cloud.r-project.org") lib <- Sys.getenv("R_LIBS_USER") dir.create(lib, recursive = TRUE, showWarnings = FALSE) +.libPaths(c(lib, .libPaths())) +bioc_pkgs <- c({bioc_packages}) +if (!requireNamespace("BiocManager", quietly = TRUE)) install.packages("BiocManager", lib = lib, repos = repos) +if (length(bioc_pkgs)) {{ + missing_bioc <- bioc_pkgs[!vapply(bioc_pkgs, requireNamespace, logical(1), quietly = TRUE)] + if (length(missing_bioc)) BiocManager::install(missing_bioc, lib = lib, ask = FALSE, update = FALSE) + missing_bioc <- bioc_pkgs[!vapply(bioc_pkgs, requireNamespace, logical(1), quietly = TRUE)] + if (length(missing_bioc)) stop("missing Bioconductor packages after install: ", paste(missing_bioc, collapse = ", ")) +}} pkgs <- c({r_packages}) -missing <- pkgs[!vapply(pkgs, requireNamespace, logical(1), quietly = TRUE, lib.loc = lib)] +missing <- pkgs[!vapply(pkgs, requireNamespace, logical(1), quietly = TRUE)] if (length(missing)) install.packages(missing, lib = lib, repos = repos, Ncpus = 8) -if (!requireNamespace("remotes", quietly = TRUE, lib.loc = lib)) install.packages("remotes", lib = lib, repos = repos) -.libPaths(c(lib, .libPaths())) +missing <- pkgs[!vapply(pkgs, requireNamespace, logical(1), quietly = TRUE)] +if (length(missing)) stop("missing CRAN packages after install: ", paste(missing, collapse = ", ")) +if (!requireNamespace("remotes", quietly = TRUE)) install.packages("remotes", lib = lib, repos = repos) +if (!requireNamespace("remotes", quietly = TRUE)) stop("missing CRAN package after install: remotes") repos_gh <- c({github}) +install_failures <- character() for (repo in repos_gh) {{ pkg <- basename(repo) + local_source <- "{local_source}" + if (!requireNamespace(pkg, quietly = TRUE) && nzchar(local_source) && dir.exists(local_source)) {{ + tryCatch( + remotes::install_local(local_source, lib = lib, upgrade = "never", dependencies = c("Depends", "Imports", "LinkingTo")), + error = function(exc) {{ + install_failures <<- c(install_failures, sprintf("%s local install failed: %s", repo, conditionMessage(exc))) + }} + ) + }} + if (!requireNamespace(pkg, quietly = TRUE)) {{ + tryCatch( + remotes::install_github(repo, lib = lib, upgrade = "never", dependencies = c("Depends", "Imports", "LinkingTo")), + error = function(exc) {{ + install_failures <<- c(install_failures, sprintf("%s install failed: %s", repo, conditionMessage(exc))) + }} + ) + }} if (!requireNamespace(pkg, quietly = TRUE)) {{ - remotes::install_github(repo, lib = lib, upgrade = "never", dependencies = TRUE) + install_failures <- c(install_failures, sprintf("%s namespace unavailable after install", pkg)) }} }} +if (length(install_failures)) stop(paste(install_failures, collapse = "; ")) sessionInfo() RS -Rscript -e '.libPaths(c(Sys.getenv("R_LIBS_USER"), .libPaths())); sink(file.path("{r_lib}", "sessionInfo.txt")); print(sessionInfo()); sink()' +{r_preflight} printf '{{"method":"{method}","status":"success","stage":"env_setup","language":"r"}}\\n' > "$OUT/run_summary.json" """ def activate_for_method(method: str, cfg: MethodConfig, root: str) -> str: if cfg.language == "r": + r_lib = f"{rebuild_env_path(method, root)}/Rlib" if method in PDC_REBUILD_FULL_METHODS else f"{root}/envs/r_libs/{method}" + r_preflight = ( + "Rscript -e '.libPaths(c(Sys.getenv(\"R_LIBS_USER\"), .libPaths())); library(CellChat); library(NMF); cat(\"r_preflight_ok\\\\n\")'" + if method == "cellchat" + else "Rscript -e '.libPaths(c(Sys.getenv(\"R_LIBS_USER\"), .libPaths())); cat(\"r_preflight_ok\\\\n\")'" + ) return f""" +module load libffi/3.4.2 >/dev/null 2>&1 || true module load cray-R/4.4.0 >/dev/null 2>&1 || true . {q(root)}/envs/python/prep/bin/activate -export R_LIBS_USER={q(root)}/envs/r_libs/{method} +python - <<'PY' +import ctypes +import anndata +import pandas +print("python_preflight_ok ctypes anndata pandas") +PY +export R_LIBS_USER={q(r_lib)} export PATH="$(dirname "$(command -v Rscript)"):$PATH" +{r_preflight} +""" + env = rebuild_env_path(method, root) if method in PDC_REBUILD_FULL_METHODS else f"{root}/envs/python/{method}" + source_exports = "" + if method in {"cellnest", "cellagentchat", "scild"}: + source_exports = f""" +export {method.upper()}_SRC={q(root + "/external_src/" + method)} +export PYTHONPATH="{pythonpath_for_method(method, root)}" +""" + if method == "cellnest": + source_exports += f""" +if [ -s {q(env + "/cellnest_image.sif")} ]; then export CELLNEST_CONTAINER={q(env + "/cellnest_image.sif")}; fi """ return f""" -module load python/3.12.3 >/dev/null 2>&1 || true -. {q(root)}/envs/python/{method}/bin/activate +{python_module_load(method)} +. {q(env)}/bin/activate +{source_exports} """ -def method_run_command(method: str, cfg: MethodConfig, root: str, stage: str) -> str: +def method_run_command( + method: str, + cfg: MethodConfig, + root: str, + stage: str, + *, + chunk_id: int | None = None, + num_chunks: int | None = None, +) -> str: phase = "smoke" if stage == "smoke" else "full" - max_lr = {"smoke": 100, "pilot": 500, "full": None}[stage] + max_lr = {"smoke": 25, "pilot": 500, "full": None}[stage] out_dir = f"{root}/runs/{stage}_common/{method}" extra = "" - if method == "commot" and stage in {"pilot", "full"}: + if method == "commot" and stage == "pilot": extra += " --chunk-id 0 --num-chunks 16" - out_dir = f"{root}/runs/{stage}_common/{method}_chunk_0" + out_dir = f"{root}/runs/{stage}_common/{method}/chunk_000_of_016" + if chunk_id is not None: + if num_chunks is None: + raise ValueError("num_chunks is required when chunk_id is provided.") + extra += f" --chunk-id {int(chunk_id)} --num-chunks {int(num_chunks)}" + out_dir = f"{root}/runs/{stage}_common/{method}/chunk_{int(chunk_id):03d}_of_{int(num_chunks):03d}" if max_lr is not None: - extra += f" --max-lr-pairs {max_lr}" + extra += f" --max-cci-pairs {max_lr}" if stage == "pilot": extra += " --bounded-mode full_cells_lr500_pilot" if cfg.language == "r": extra += " --rscript Rscript" + job_suffix = "" if chunk_id is None else f"_chunk_{int(chunk_id):03d}_of_{int(num_chunks or 0):03d}" + cellagentchat_exports = "" + if method == "cellagentchat": + cellagentchat_exports = """ +export CELLAGENTCHAT_FEATURE_SELECTION="${CELLAGENTCHAT_FEATURE_SELECTION:-0}" +export CELLAGENTCHAT_EPOCHS="${CELLAGENTCHAT_EPOCHS:-10}" +export CELLAGENTCHAT_MAX_STEPS="${CELLAGENTCHAT_MAX_STEPS:-1}" +""" return f""" OUT={q(out_dir)} mkdir -p "$OUT" +rm -f "$OUT/method_card.md" "$OUT/params.json" "$OUT/run_summary.json" "$OUT"/*_standardized.tsv "$OUT"/*_standardized.tsv.gz "$OUT/standardized_results.tsv" "$OUT/standardized_results.tsv.gz" trap 'rc=$?; mkdir -p "$OUT"; printf "# {method} PDC method card\\n\\n- Status: failed\\n- Stage: {stage}\\n- Exit code: %s\\n- PDC note: {cfg.pdc_note}\\n" "$rc" > "$OUT/method_card.md"; exit "$rc"' ERR {activate_for_method(method, cfg, root)} +{cellagentchat_exports} python "$ROOT/repo/benchmarking/cci_2026_atera/scripts/run_method.py" \ --method {q(method)} \ --input-manifest "$ROOT/data/input_manifest.json" \ @@ -277,7 +550,87 @@ def method_run_command(method: str, cfg: MethodConfig, root: str, stage: str) -> --phase {phase} \ --output-dir "$OUT" \ --gzip-standardized \ - --job-id {q(stage + "_common_" + method)}{extra} + --job-id {q(stage + "_common_" + method + job_suffix)}{extra} +""" + + +def aggregate_chunk_command(method: str, cfg: MethodConfig, root: str, stage: str, *, num_chunks: int) -> str: + if method != "cellagentchat" or stage != "full": + raise ValueError("Only cellagentchat full chunk aggregation is supported.") + out_dir = f"{root}/runs/{stage}_common/{method}" + return f""" +OUT={q(out_dir)} +mkdir -p "$OUT" +rm -f "$OUT/method_card.md" "$OUT/run_summary.json" "$OUT/{method}_standardized.tsv" "$OUT/{method}_standardized.tsv.gz" "$OUT/standardized_results.tsv" "$OUT/standardized_results.tsv.gz" +trap 'rc=$?; mkdir -p "$OUT"; printf "# {method} PDC method card\\n\\n- Status: failed\\n- Stage: {stage}_aggregate\\n- Exit code: %s\\n- PDC note: {cfg.pdc_note}\\n" "$rc" > "$OUT/method_card.md"; exit "$rc"' ERR +{activate_for_method(method, cfg, root)} +python - <<'PY' +import json +from pathlib import Path + +import numpy as np +import pandas as pd + +from pyXenium.benchmarking.cci_atera import STANDARDIZED_RESULT_COLUMNS, _resolve_ordered_rank + +out = Path({out_dir!r}) +expected = {int(num_chunks)} +failed_statuses = {{"failed", "error", "out_of_memory", "timeout", "cancelled", "dependencyneversatisfied", "dependency_never_satisfied"}} +frames = [] +inputs = [] +missing = [] +blocked = [] +for idx in range(expected): + chunk_dir = out / f"chunk_{{idx:03d}}_of_{{expected:03d}}" + summary_path = chunk_dir / "run_summary.json" + summary = {{}} + if summary_path.exists(): + summary = json.loads(summary_path.read_text(encoding="utf-8")) + status = str(summary.get("status") or "").strip().lower() + if status in failed_statuses or (chunk_dir / "method_card.md").exists(): + blocked.append(idx) + continue + candidates = sorted(chunk_dir.glob("*standardized.tsv.gz")) + sorted(chunk_dir.glob("*standardized.tsv")) + if not candidates: + missing.append(idx) + continue + path = candidates[-1] + table = pd.read_csv(path, sep="\\t", compression="infer") + missing_columns = [column for column in STANDARDIZED_RESULT_COLUMNS if column not in table.columns] + if missing_columns: + raise ValueError(f"Chunk {{idx}} output {{path}} is missing standardized columns: {{missing_columns}}") + frames.append(table.copy()) + inputs.append(str(path)) +if missing or blocked: + raise RuntimeError(f"Cannot aggregate {method}: missing_chunks={{missing}}, blocked_chunks={{blocked}}") +if not frames: + raise RuntimeError(f"Cannot aggregate {method}: no chunk tables were found.") +combined = pd.concat(frames, ignore_index=True) +score = pd.to_numeric(combined["score_raw"], errors="coerce") +pvalues = pd.to_numeric(combined["fdr_or_pvalue"], errors="coerce") if "fdr_or_pvalue" in combined.columns else None +rank, rank_fraction = _resolve_ordered_rank(score, pvalues) +combined["rank_within_method"] = rank.astype(float) +combined["rank_fraction"] = rank_fraction.astype(float) +combined["score_std"] = rank_fraction.astype(float) +extra_columns = [column for column in combined.columns if column not in STANDARDIZED_RESULT_COLUMNS] +combined = combined.loc[:, STANDARDIZED_RESULT_COLUMNS + extra_columns].sort_values("rank_within_method").reset_index(drop=True) +standardized_path = out / "{method}_standardized.tsv.gz" +combined.to_csv(standardized_path, sep="\\t", index=False, compression="gzip") +summary = {{ + "method": "{method}", + "status": "success", + "stage": "{stage}_aggregate", + "database_mode": "common-db", + "standardized_tsv": str(standardized_path), + "standardized_tsv_gz": str(standardized_path), + "n_rows": int(len(combined)), + "num_chunks": expected, + "chunk_inputs": inputs, + "top_hit": combined.head(1).to_dict(orient="records"), +}} +(out / "run_summary.json").write_text(json.dumps(summary, indent=2) + "\\n", encoding="utf-8") +print(json.dumps(summary, indent=2)) +PY """ @@ -308,12 +661,12 @@ def job_script( set -euo pipefail export ROOT={q(root)} -export PDC_LR_ROOT="$ROOT" +export PDC_CCI_ROOT="$ROOT" export TMPDIR="$ROOT/tmp" export PYTHONPATH="$ROOT/repo/src:${{PYTHONPATH:-}}" export OMP_NUM_THREADS={cpus} export MKL_NUM_THREADS={cpus} -mkdir -p "$ROOT"/{{logs,runs,results,reports,tmp,slurm,envs/python,envs/r_libs}} +mkdir -p "$ROOT"/{{logs,runs,results,reports,tmp,slurm,envs/python,envs/r_libs,envs/{REBUILD_ENV_TAG},external_src}} mkdir -p "$ROOT/configs" cp -f "$ROOT"/repo/benchmarking/cci_2026_atera/configs/* "$ROOT/configs/" 2>/dev/null || true cd "$ROOT/repo" @@ -321,7 +674,16 @@ def job_script( """ -def build_jobs(methods: list[str], root: str, account: str, stages: set[str], include_full: bool) -> list[dict[str, Any]]: +def build_jobs( + methods: list[str], + root: str, + account: str, + stages: set[str], + include_full: bool, + *, + commot_chunks: int = 16, + cellagentchat_chunks: int = CELLAGENTCHAT_FULL_CHUNKS, +) -> list[dict[str, Any]]: jobs: list[dict[str, Any]] = [] if "prepare" in stages: jobs.append( @@ -379,7 +741,6 @@ def build_jobs(methods: list[str], root: str, account: str, stages: set[str], in continue if stage not in stages and not (stage == "full" and include_full): continue - run_id = f"pdc_{stage}_common_{method}" deps = [] if "prepare" in stages: deps.append("pdc_prepare_full_bundle") @@ -387,29 +748,77 @@ def build_jobs(methods: list[str], root: str, account: str, stages: set[str], in deps.append(env_id) if prior_stage_id: deps.append(prior_stage_id) - jobs.append( - { - "job_id": run_id, - "job_type": f"{stage}_common", - "method": method, - "partition": cfg.partition, - "cpus": cfg.cpus, - "memory": cfg.memory, - "time": cfg.time, - "dependencies": deps, - "script": job_script( - job_id=run_id, - root=root, - account=account, - partition=cfg.partition, - cpus=cfg.cpus, - memory=cfg.memory, - time_limit=cfg.time, - body=method_run_command(method, cfg, root, stage), - ), - } - ) - prior_stage_id = run_id + + chunk_ids: list[int | None] + num_chunks: int | None + if method == "commot" and stage == "full" and int(commot_chunks) > 1: + chunk_ids = list(range(int(commot_chunks))) + num_chunks = int(commot_chunks) + elif method == "cellagentchat" and stage == "full" and int(cellagentchat_chunks) > 1: + chunk_ids = list(range(int(cellagentchat_chunks))) + num_chunks = int(cellagentchat_chunks) + else: + chunk_ids = [None] + num_chunks = None + + stage_run_ids: list[str] = [] + for chunk_id in chunk_ids: + chunk_suffix = "" if chunk_id is None else f"_chunk_{int(chunk_id):03d}_of_{int(num_chunks or 0):03d}" + run_id = f"pdc_{stage}_common_{method}{chunk_suffix}" + stage_run_ids.append(run_id) + jobs.append( + { + "job_id": run_id, + "job_type": f"{stage}_common", + "method": method, + "chunk_id": chunk_id, + "num_chunks": num_chunks, + "partition": cfg.partition, + "cpus": cfg.cpus, + "memory": cfg.memory, + "time": cfg.time, + "dependencies": deps, + "script": job_script( + job_id=run_id, + root=root, + account=account, + partition=cfg.partition, + cpus=cfg.cpus, + memory=cfg.memory, + time_limit=cfg.time, + body=method_run_command(method, cfg, root, stage, chunk_id=chunk_id, num_chunks=num_chunks), + ), + } + ) + if method == "cellagentchat" and stage == "full" and num_chunks is not None and len(stage_run_ids) > 1: + aggregate_id = f"pdc_{stage}_common_{method}_aggregate" + jobs.append( + { + "job_id": aggregate_id, + "job_type": f"{stage}_common_aggregate", + "method": method, + "chunk_id": None, + "num_chunks": num_chunks, + "partition": "shared", + "cpus": 4, + "memory": "32G", + "time": "01:00:00", + "dependencies": stage_run_ids, + "script": job_script( + job_id=aggregate_id, + root=root, + account=account, + partition="shared", + cpus=4, + memory="32G", + time_limit="01:00:00", + body=aggregate_chunk_command(method, cfg, root, stage, num_chunks=num_chunks), + ), + } + ) + prior_stage_id = aggregate_id + else: + prior_stage_id = stage_run_ids[0] if len(stage_run_ids) == 1 else None return jobs @@ -424,12 +833,53 @@ def write_remote_text(host: str, remote_path: str, text: str) -> None: Path(tmp_name).unlink(missing_ok=True) +def dependency_clause(job: dict[str, Any], slurm_ids: dict[str, str]) -> str: + dep_ids: dict[str, list[str]] = {"afterok": [], "afterany": []} + for dep in job.get("dependencies", []): + if dep not in slurm_ids: + continue + mode = "afterok" + dep_ids[mode].append(slurm_ids[dep]) + clauses = [f"{mode}:{':'.join(ids)}" for mode, ids in dep_ids.items() if ids] + return ",".join(clauses) + + +def ensure_remote_sources(host: str, root: str, methods: list[str]) -> list[dict[str, Any]]: + staged: list[dict[str, Any]] = [] + for method in methods: + if method not in SOURCE_CHECKOUTS: + continue + command = f"set -euo pipefail\nROOT={q(root)}\n" + source_checkout_command(method, root) + completed = ssh(host, "bash -lc " + q(command), check=False) + staged.append( + { + "method": method, + "status": "staged" if completed.returncode == 0 else "stage_failed", + "returncode": completed.returncode, + "stdout": completed.stdout, + "stderr": completed.stderr, + } + ) + if completed.returncode != 0: + raise RuntimeError( + f"Failed to stage source checkout for {method} on {host}:{root}\n" + f"STDOUT:\n{completed.stdout}\nSTDERR:\n{completed.stderr}" + ) + return staged + + def submit_jobs(host: str, root: str, jobs: list[dict[str, Any]]) -> list[dict[str, Any]]: submitted: list[dict[str, Any]] = [] slurm_ids: dict[str, str] = {} + script_paths: dict[str, str] = {} + source_methods = sorted({str(job.get("method")) for job in jobs if str(job.get("method")) in SOURCE_CHECKOUTS}) + ensure_remote_sources(host, root, source_methods) for job in jobs: script_path = f"{root}/slurm/{job['job_id']}.sbatch" write_remote_text(host, script_path, str(job["script"])) + script_paths[str(job["job_id"])] = script_path + for job in jobs: + script_path = script_paths[str(job["job_id"])] missing_deps = [dep for dep in job.get("dependencies", []) if dep not in slurm_ids] if missing_deps: submitted.append( @@ -437,10 +887,10 @@ def submit_jobs(host: str, root: str, jobs: list[dict[str, Any]]) -> list[dict[s | {"script_path": script_path, "status": "skipped_missing_dependency", "missing_dependencies": missing_deps} ) continue - dep_ids = [slurm_ids[dep] for dep in job.get("dependencies", []) if dep in slurm_ids] command = f"sbatch --parsable" - if dep_ids: - command += " --dependency=afterok:" + ":".join(dep_ids) + deps = dependency_clause(job, slurm_ids) + if deps: + command += " --dependency=" + deps command += f" {q(script_path)}" completed = ssh(host, command, check=False) if completed.returncode != 0: @@ -469,9 +919,11 @@ def main() -> None: parser.add_argument("--host", default=DEFAULT_PDC_HOST) parser.add_argument("--remote-root", default=DEFAULT_PDC_ROOT) parser.add_argument("--account", default=DEFAULT_ACCOUNT) - parser.add_argument("--methods", default=",".join(ALL_METHODS)) - parser.add_argument("--stages", default="prepare,env,smoke,pilot") + parser.add_argument("--methods", default=",".join(PDC_REBUILD_FULL_METHODS)) + parser.add_argument("--stages", default="prepare,env") parser.add_argument("--include-full", action="store_true") + parser.add_argument("--commot-chunks", type=int, default=16) + parser.add_argument("--cellagentchat-chunks", type=int, default=CELLAGENTCHAT_FULL_CHUNKS) parser.add_argument("--submit", action="store_true") parser.add_argument("--output-json", default=None) args = parser.parse_args() @@ -481,7 +933,15 @@ def main() -> None: if unknown: raise SystemExit(f"Unknown methods: {unknown}") stages = {item.strip().lower() for item in args.stages.split(",") if item.strip()} - jobs = build_jobs(methods, args.remote_root.rstrip("/"), args.account, stages, args.include_full) + jobs = build_jobs( + methods, + args.remote_root.rstrip("/"), + args.account, + stages, + args.include_full, + commot_chunks=args.commot_chunks, + cellagentchat_chunks=args.cellagentchat_chunks, + ) manifest: dict[str, Any] = { "kind": "pdc_job_matrix", "created_at": datetime.now(timezone.utc).isoformat(), @@ -491,6 +951,13 @@ def main() -> None: "methods": methods, "stages": sorted(stages), "include_full": args.include_full, + "rebuild_env_tag": REBUILD_ENV_TAG, + "rebuild_full_methods": list(PDC_REBUILD_FULL_METHODS), + "source_checkouts": SOURCE_CHECKOUTS, + "a100_authoritative_full_methods": list(A100_AUTHORITATIVE_FULL_METHODS), + "pdc_full_backfill_methods": list(PDC_FULL_BACKFILL_METHODS), + "commot_chunks": int(args.commot_chunks), + "cellagentchat_chunks": int(args.cellagentchat_chunks), "jobs": [{k: v for k, v in job.items() if k != "script"} for job in jobs], } if args.submit: diff --git a/benchmarking/cci_2026_atera/scripts/topolink_cci_validation_framework.py b/benchmarking/cci_2026_atera/scripts/topolink_cci_validation_framework.py new file mode 100644 index 0000000..1e3fb46 --- /dev/null +++ b/benchmarking/cci_2026_atera/scripts/topolink_cci_validation_framework.py @@ -0,0 +1,825 @@ +from __future__ import annotations + +import argparse +import gzip +import json +import math +import time +from dataclasses import dataclass +from pathlib import Path +from typing import Any + +import matplotlib + +matplotlib.use("Agg") +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +from scipy import sparse +from scipy.io import mmread + + +DEFAULT_ROOT = Path("/cfs/klemming/scratch/h/hutaobo/pyxenium_cci_benchmark_2026-04") +COMPONENTS = [ + "sender_anchor", + "receiver_anchor", + "structure_bridge", + "sender_expr", + "receiver_expr", + "local_contact", + "prior_confidence", +] + + +@dataclass(frozen=True) +class TargetAxis: + ligand: str + receptor: str + sender: str + receiver: str + biology_label: str + target_panel: tuple[str, ...] + + @property + def axis_id(self) -> str: + return f"{self.ligand}-{self.receptor}|{self.sender}->{self.receiver}" + + +TARGET_AXES = [ + TargetAxis( + "VWF", + "SELP", + "Endothelial Cells", + "Endothelial Cells", + "WPB / endothelial activation", + ("VWF", "SELP", "CD63", "ANGPT2", "THBD", "PLAT", "SERPINE1"), + ), + TargetAxis( + "VWF", + "LRP1", + "Endothelial Cells", + "CAFs, DCIS Associated", + "vascular-stromal matrix/scavenger axis", + ("VWF", "LRP1", "HSPG2", "COL4A1", "COL4A2", "MMP2", "THBS2"), + ), + TargetAxis( + "MMRN2", + "CD93", + "Endothelial Cells", + "Endothelial Cells", + "CD93-MMRN2 angiogenesis", + ("MMRN2", "CD93", "CLEC14A", "KDR", "FLT1", "PECAM1", "EMCN"), + ), + TargetAxis( + "DLL4", + "NOTCH3", + "Endothelial Cells", + "Pericytes", + "endothelial-pericyte Notch", + ("DLL4", "NOTCH3", "NOTCH4", "JAG1", "HEY1", "HES1", "PDGFRB", "RGS5"), + ), + TargetAxis( + "CXCL12", + "CXCR4", + "CAFs, DCIS Associated", + "T Lymphocytes", + "CAF-immune chemokine recruitment", + ("CXCL12", "CXCR4", "CXCR3", "CCL19", "CCL21", "CD3D", "CD3E", "IL7R"), + ), + TargetAxis( + "CD48", + "CD2", + "T Lymphocytes", + "T Lymphocytes", + "T-cell adhesion/co-stimulation", + ("CD48", "CD2", "CD3D", "CD3E", "TRAC", "IL7R", "LCK"), + ), + TargetAxis( + "JAG1", + "NOTCH2", + "11q13 Invasive Tumor Cells", + "11q13 Invasive Tumor Cells", + "tumor-intrinsic Notch signaling", + ("JAG1", "NOTCH2", "NOTCH1", "HES1", "HEY1", "MYC", "CCND1"), + ), +] + + +def qnorm_sf(z: float) -> float: + """Normal survival function without depending on scipy.stats import latency.""" + if not np.isfinite(z): + return float("nan") + return 0.5 * math.erfc(z / math.sqrt(2.0)) + + +def geometric_mean(values: np.ndarray, axis: int | None = None) -> np.ndarray: + clipped = np.clip(values.astype(float), 1e-12, None) + return np.exp(np.mean(np.log(clipped), axis=axis)) + + +def load_manifest(root: Path) -> dict[str, Any]: + manifest_path = root / "data" / "input_manifest.json" + with manifest_path.open("r", encoding="utf-8") as handle: + return json.load(handle) + + +def read_scores(root: Path) -> pd.DataFrame: + path = root / "runs" / "full_common" / "pyxenium" / "pyxenium_scores.tsv" + scores = pd.read_csv(path, sep="\t") + scores = scores.sort_values("CCI_score", ascending=False, kind="mergesort").reset_index(drop=True) + scores["global_rank"] = np.arange(1, len(scores) + 1) + return scores + + +def find_target_rows(scores: pd.DataFrame) -> pd.DataFrame: + rows: list[pd.Series] = [] + for axis in TARGET_AXES: + exact = scores[ + (scores["ligand"] == axis.ligand) + & (scores["receptor"] == axis.receptor) + & (scores["sender_celltype"] == axis.sender) + & (scores["receiver_celltype"] == axis.receiver) + ] + if exact.empty: + pair_any = scores[(scores["ligand"] == axis.ligand) & (scores["receptor"] == axis.receptor)] + if pair_any.empty: + continue + row = pair_any.iloc[0].copy() + row["selection_note"] = "exact_sender_receiver_missing_best_lr_pair_used" + else: + row = exact.iloc[0].copy() + row["selection_note"] = "exact" + row["axis_id"] = axis.axis_id + row["biology_label"] = axis.biology_label + rows.append(row) + if not rows: + raise RuntimeError("No target LR axes were found in pyxenium_scores.tsv") + return pd.DataFrame(rows).reset_index(drop=True) + + +def component_ablation(scores: pd.DataFrame, targets: pd.DataFrame) -> pd.DataFrame: + comp = scores[COMPONENTS].astype(float).to_numpy() + log_comp = np.log(np.clip(comp, 1e-12, None)) + log_sum = log_comp.sum(axis=1) + target_keys = { + (row.ligand, row.receptor, row.sender_celltype, row.receiver_celltype): row.axis_id + for row in targets.itertuples(index=False) + } + rows: list[dict[str, Any]] = [] + key_to_index = { + (row.ligand, row.receptor, row.sender_celltype, row.receiver_celltype): i + for i, row in enumerate(scores.itertuples(index=False)) + if (row.ligand, row.receptor, row.sender_celltype, row.receiver_celltype) in target_keys + } + for component_index, component in enumerate(COMPONENTS): + ablated_scores = np.exp((log_sum - log_comp[:, component_index]) / (len(COMPONENTS) - 1)) + for key, axis_id in target_keys.items(): + idx = key_to_index.get(key) + if idx is None: + continue + value = float(ablated_scores[idx]) + rank = int(np.count_nonzero(ablated_scores > value) + 1) + rows.append( + { + "axis_id": axis_id, + "removed_component": component, + "score_without_component": value, + "rank_without_component": rank, + } + ) + return pd.DataFrame(rows) + + +def load_bundle_expression(manifest: dict[str, Any]) -> tuple[pd.DataFrame, pd.DataFrame, sparse.csr_matrix]: + bundle = manifest["full_bundle"] + genes = pd.read_csv(bundle["genes_tsv"], sep="\t") + meta = pd.read_csv(bundle["meta_tsv"], sep="\t") + matrix = mmread(bundle["counts_symbol_mtx"]).tocsr() + if matrix.shape[0] == len(meta) and matrix.shape[1] == len(genes): + matrix = matrix.T.tocsr() + if matrix.shape[0] != len(genes) or matrix.shape[1] != len(meta): + raise RuntimeError( + "Sparse matrix shape does not match genes/meta: " + f"matrix={matrix.shape}, genes={len(genes)}, cells={len(meta)}" + ) + return genes, meta, matrix + + +def summarize_expression( + genes: pd.DataFrame, + meta: pd.DataFrame, + matrix: sparse.csr_matrix, +) -> tuple[pd.DataFrame, np.ndarray, np.ndarray, dict[str, int]]: + gene_symbols = genes["gene_symbol"].astype(str).str.upper().to_numpy() + gene_to_index = {gene: i for i, gene in enumerate(gene_symbols)} + cell_types = pd.Categorical(meta["cell_type"].astype(str)) + indicator = sparse.csr_matrix( + ( + np.ones(len(cell_types), dtype=np.float32), + (np.arange(len(cell_types)), cell_types.codes), + ), + shape=(len(cell_types), len(cell_types.categories)), + ) + celltype_sizes = np.asarray(indicator.sum(axis=0)).ravel() + sum_by_celltype = (matrix @ indicator).toarray() + detected = matrix.copy() + detected.data = np.ones_like(detected.data, dtype=np.float32) + nnz_by_celltype = (detected @ indicator).toarray() + mean_by_celltype = sum_by_celltype / np.maximum(celltype_sizes, 1.0) + det_by_celltype = nnz_by_celltype / np.maximum(celltype_sizes, 1.0) + expr_summary_rows: list[dict[str, Any]] = [] + needed = sorted({g for axis in TARGET_AXES for g in (axis.ligand, axis.receptor, *axis.target_panel)}) + for gene in needed: + idx = gene_to_index.get(gene.upper()) + if idx is None: + expr_summary_rows.append({"gene": gene, "detected_in_wta": False}) + continue + means = mean_by_celltype[idx, :] + dets = det_by_celltype[idx, :] + order = np.argsort(-means) + for rank, ct_idx in enumerate(order[:5], start=1): + expr_summary_rows.append( + { + "gene": gene, + "detected_in_wta": True, + "top_celltype_rank": rank, + "cell_type": str(cell_types.categories[ct_idx]), + "mean_expr": float(means[ct_idx]), + "detection_fraction": float(dets[ct_idx]), + } + ) + expr_summary = pd.DataFrame(expr_summary_rows) + return expr_summary, mean_by_celltype, det_by_celltype, gene_to_index + + +def expression_specificity( + targets: pd.DataFrame, + meta: pd.DataFrame, + mean_by_celltype: np.ndarray, + det_by_celltype: np.ndarray, + gene_to_index: dict[str, int], +) -> pd.DataFrame: + categories = list(pd.Categorical(meta["cell_type"].astype(str)).categories) + rows: list[dict[str, Any]] = [] + for row in targets.itertuples(index=False): + lig_idx = gene_to_index.get(str(row.ligand).upper()) + rec_idx = gene_to_index.get(str(row.receptor).upper()) + sender_idx = categories.index(row.sender_celltype) if row.sender_celltype in categories else None + receiver_idx = categories.index(row.receiver_celltype) if row.receiver_celltype in categories else None + out: dict[str, Any] = { + "axis_id": row.axis_id, + "ligand": row.ligand, + "receptor": row.receptor, + "sender": row.sender_celltype, + "receiver": row.receiver_celltype, + } + for role, gene_idx, celltype_idx in ( + ("ligand_sender", lig_idx, sender_idx), + ("receptor_receiver", rec_idx, receiver_idx), + ): + if gene_idx is None or celltype_idx is None: + out[f"{role}_mean"] = np.nan + out[f"{role}_detection_fraction"] = np.nan + out[f"{role}_celltype_rank"] = np.nan + out[f"{role}_specificity_ratio"] = np.nan + continue + means = mean_by_celltype[gene_idx, :] + dets = det_by_celltype[gene_idx, :] + rank = int(np.where(np.argsort(-means) == celltype_idx)[0][0] + 1) + out[f"{role}_mean"] = float(means[celltype_idx]) + out[f"{role}_detection_fraction"] = float(dets[celltype_idx]) + out[f"{role}_celltype_rank"] = rank + out[f"{role}_specificity_ratio"] = float(means[celltype_idx] / max(float(np.max(means)), 1e-12)) + rows.append(out) + return pd.DataFrame(rows) + + +def matched_gene_controls( + targets: pd.DataFrame, + meta: pd.DataFrame, + mean_by_celltype: np.ndarray, + det_by_celltype: np.ndarray, + gene_to_index: dict[str, int], + *, + n_controls: int, + seed: int, +) -> pd.DataFrame: + rng = np.random.default_rng(seed) + cell_types = pd.Categorical(meta["cell_type"].astype(str)) + categories = list(cell_types.categories) + celltype_sizes = np.asarray(pd.Series(cell_types).value_counts(sort=False), dtype=float) + weights = celltype_sizes / max(float(celltype_sizes.sum()), 1.0) + global_mean = mean_by_celltype @ weights + global_det = det_by_celltype @ weights + all_indices = np.arange(mean_by_celltype.shape[0]) + protected = {gene_to_index[g.upper()] for axis in TARGET_AXES for g in (axis.ligand, axis.receptor) if g.upper() in gene_to_index} + rows: list[dict[str, Any]] = [] + + def nearest_pool(gene_idx: int, pool_size: int = 500) -> np.ndarray: + distance = np.abs(np.log1p(global_mean) - np.log1p(global_mean[gene_idx])) + distance += np.abs(global_det - global_det[gene_idx]) + distance[list(protected)] = np.inf + distance[gene_idx] = np.inf + valid = all_indices[np.isfinite(distance)] + if len(valid) == 0: + return np.array([], dtype=int) + ordered = valid[np.argsort(distance[valid])] + return ordered[: min(pool_size, len(ordered))] + + for row in targets.itertuples(index=False): + lig_idx = gene_to_index.get(str(row.ligand).upper()) + rec_idx = gene_to_index.get(str(row.receptor).upper()) + if lig_idx is None or rec_idx is None or row.sender_celltype not in categories or row.receiver_celltype not in categories: + rows.append({"axis_id": row.axis_id, "matched_gene_status": "missing_gene_or_celltype"}) + continue + sender_idx = categories.index(row.sender_celltype) + receiver_idx = categories.index(row.receiver_celltype) + lig_pool = nearest_pool(lig_idx) + rec_pool = nearest_pool(rec_idx) + if len(lig_pool) == 0 or len(rec_pool) == 0: + rows.append({"axis_id": row.axis_id, "matched_gene_status": "no_matched_pool"}) + continue + lig_sample = rng.choice(lig_pool, size=n_controls, replace=len(lig_pool) < n_controls) + rec_sample = rng.choice(rec_pool, size=n_controls, replace=len(rec_pool) < n_controls) + + def expr_score(lidx: int, ridx: int) -> float: + lig_ratio = mean_by_celltype[lidx, sender_idx] / max(float(np.max(mean_by_celltype[lidx, :])), 1e-12) + rec_ratio = mean_by_celltype[ridx, receiver_idx] / max(float(np.max(mean_by_celltype[ridx, :])), 1e-12) + lig_det = det_by_celltype[lidx, sender_idx] + rec_det = det_by_celltype[ridx, receiver_idx] + return float(geometric_mean(np.array([lig_ratio, rec_ratio, lig_det, rec_det]))) + + observed = expr_score(lig_idx, rec_idx) + control_scores = np.array([expr_score(lidx, ridx) for lidx, ridx in zip(lig_sample, rec_sample)], dtype=float) + rows.append( + { + "axis_id": row.axis_id, + "matched_gene_status": "success", + "n_controls": int(len(control_scores)), + "observed_expression_specificity_score": observed, + "control_mean": float(np.mean(control_scores)), + "control_sd": float(np.std(control_scores, ddof=1)), + "matched_gene_z": float((observed - np.mean(control_scores)) / max(float(np.std(control_scores, ddof=1)), 1e-12)), + "matched_gene_percentile": float(np.mean(control_scores <= observed)), + } + ) + return pd.DataFrame(rows) + + +def spatial_abundance_null(scores: pd.DataFrame, targets: pd.DataFrame, meta: pd.DataFrame) -> pd.DataFrame: + counts = meta["cell_type"].value_counts().to_dict() + total_cells = len(meta) + edge_counts = scores[["sender_celltype", "receiver_celltype", "cross_edge_count"]].drop_duplicates() + total_edges = float(edge_counts["cross_edge_count"].sum()) + rows: list[dict[str, Any]] = [] + for row in targets.itertuples(index=False): + p = (counts.get(row.sender_celltype, 0) / total_cells) * (counts.get(row.receiver_celltype, 0) / total_cells) + expected = total_edges * p + variance = total_edges * p * max(1.0 - p, 1e-12) + z = (float(row.cross_edge_count) - expected) / math.sqrt(max(variance, 1e-12)) + same_pair = scores[ + (scores["sender_celltype"] == row.sender_celltype) + & (scores["receiver_celltype"] == row.receiver_celltype) + ] + same_lr = scores[(scores["ligand"] == row.ligand) & (scores["receptor"] == row.receptor)] + within_cellpair_rank = int(np.count_nonzero(same_pair["CCI_score"].to_numpy() > float(row.CCI_score)) + 1) + within_lr_rank = int(np.count_nonzero(same_lr["CCI_score"].to_numpy() > float(row.CCI_score)) + 1) + rows.append( + { + "axis_id": row.axis_id, + "observed_cross_edge_count": int(row.cross_edge_count), + "expected_cross_edge_count_abundance_null": float(expected), + "cross_edge_enrichment_fold": float(row.cross_edge_count / max(expected, 1e-12)), + "cross_edge_enrichment_z": float(z), + "cross_edge_enrichment_p_approx": float(qnorm_sf(z)), + "local_contact": float(row.local_contact), + "contact_coverage": float(row.contact_coverage), + "within_sender_receiver_rank": within_cellpair_rank, + "within_sender_receiver_n": int(len(same_pair)), + "within_sender_receiver_percentile": float(1.0 - (within_cellpair_rank - 1) / max(len(same_pair), 1)), + "within_lr_pair_rank": within_lr_rank, + "within_lr_pair_n": int(len(same_lr)), + "within_lr_pair_percentile": float(1.0 - (within_lr_rank - 1) / max(len(same_lr), 1)), + } + ) + return pd.DataFrame(rows) + + +def standardized_paths(root: Path) -> dict[str, Path]: + paths: dict[str, Path] = {} + full_common = root / "runs" / "full_common" + for method_dir in sorted(full_common.glob("*")): + if not method_dir.is_dir() or method_dir.name == "pyxenium": + continue + matches = sorted(method_dir.glob("*standardized.tsv")) + sorted(method_dir.glob("*standardized.tsv.gz")) + if matches: + paths[method_dir.name] = matches[0] + return paths + + +def read_standardized_table(path: Path) -> pd.DataFrame: + compression = "gzip" if path.suffix == ".gz" else None + usecols = [ + "method", + "ligand", + "receptor", + "sender", + "receiver", + "score_std", + "rank_within_method", + "fdr_or_pvalue", + "spatial_support_type", + ] + return pd.read_csv(path, sep="\t", compression=compression, usecols=lambda col: col in usecols) + + +def cross_method_support(root: Path, targets: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + detail_rows: list[dict[str, Any]] = [] + summary_rows: list[dict[str, Any]] = [] + for method, path in standardized_paths(root).items(): + table = read_standardized_table(path) + for row in targets.itertuples(index=False): + exact = table[ + (table["ligand"] == row.ligand) + & (table["receptor"] == row.receptor) + & (table["sender"] == row.sender_celltype) + & (table["receiver"] == row.receiver_celltype) + ] + lr_any = table[(table["ligand"] == row.ligand) & (table["receptor"] == row.receptor)] + axis_any = table[(table["sender"] == row.sender_celltype) & (table["receiver"] == row.receiver_celltype)] + detail_rows.append( + { + "axis_id": row.axis_id, + "method": method, + "exact_support": not exact.empty, + "same_lr_any_celltype_support": not lr_any.empty, + "same_sender_receiver_support": not axis_any.empty, + "exact_best_rank": float(exact["rank_within_method"].min()) if not exact.empty else np.nan, + "same_lr_best_rank": float(lr_any["rank_within_method"].min()) if not lr_any.empty else np.nan, + "same_lr_best_score_std": float(lr_any["score_std"].max()) if not lr_any.empty else np.nan, + "artifact_path": str(path), + } + ) + details = pd.DataFrame(detail_rows) + for axis_id, grp in details.groupby("axis_id"): + summary_rows.append( + { + "axis_id": axis_id, + "cross_method_exact_count": int(grp["exact_support"].sum()), + "cross_method_same_lr_count": int(grp["same_lr_any_celltype_support"].sum()), + "cross_method_same_sender_receiver_count": int(grp["same_sender_receiver_support"].sum()), + "supporting_methods_exact": ",".join(grp.loc[grp["exact_support"], "method"].astype(str)), + "supporting_methods_same_lr": ",".join(grp.loc[grp["same_lr_any_celltype_support"], "method"].astype(str)), + } + ) + return pd.DataFrame(summary_rows), details + + +def receiver_panel_support( + targets: pd.DataFrame, + meta: pd.DataFrame, + mean_by_celltype: np.ndarray, + gene_to_index: dict[str, int], +) -> pd.DataFrame: + categories = list(pd.Categorical(meta["cell_type"].astype(str)).categories) + axis_to_target = {axis.axis_id: axis for axis in TARGET_AXES} + rows: list[dict[str, Any]] = [] + for row in targets.itertuples(index=False): + axis = axis_to_target[row.axis_id] + if row.receiver_celltype not in categories: + continue + receiver_idx = categories.index(row.receiver_celltype) + present = [gene_to_index[g.upper()] for g in axis.target_panel if g.upper() in gene_to_index] + if not present: + rows.append({"axis_id": row.axis_id, "target_panel_present_n": 0}) + continue + ratios = [] + for gene_idx in present: + means = mean_by_celltype[gene_idx, :] + ratios.append(float(means[receiver_idx] / max(float(np.max(means)), 1e-12))) + rows.append( + { + "axis_id": row.axis_id, + "target_panel_present_n": len(present), + "receiver_context_panel_score": float(np.mean(ratios)), + "receiver_context_panel_genes": ",".join([axis.target_panel[i] for i, g in enumerate(axis.target_panel) if g.upper() in gene_to_index]), + } + ) + return pd.DataFrame(rows) + + +def classify_evidence(evidence: pd.DataFrame) -> pd.DataFrame: + rows: list[dict[str, Any]] = [] + for row in evidence.itertuples(index=False): + expr_ok = ( + pd.notna(row.ligand_sender_specificity_ratio) + and pd.notna(row.receptor_receiver_specificity_ratio) + and row.ligand_sender_specificity_ratio >= 0.75 + and row.receptor_receiver_specificity_ratio >= 0.50 + ) + spatial_ok = pd.notna(row.cross_edge_enrichment_z) and row.cross_edge_enrichment_z >= 2.0 + matched_ok = pd.notna(row.matched_gene_percentile) and row.matched_gene_percentile >= 0.90 + ablation_ok = pd.notna(row.max_rank_after_component_removal) and row.max_rank_after_component_removal <= 250 + cross_ok = (getattr(row, "cross_method_exact_count", 0) >= 1) or (getattr(row, "cross_method_same_lr_count", 0) >= 2) + context_ok = pd.notna(row.receiver_context_panel_score) and row.receiver_context_panel_score >= 0.50 + support_count = sum([expr_ok, spatial_ok, matched_ok, ablation_ok, cross_ok, context_ok]) + if support_count >= 5: + evidence_class = "strong" + elif support_count >= 3: + evidence_class = "moderate" + else: + evidence_class = "hypothesis_only" + rows.append( + { + "axis_id": row.axis_id, + "expression_support": expr_ok, + "spatial_abundance_null_support": spatial_ok, + "matched_gene_control_support": matched_ok, + "component_ablation_support": ablation_ok, + "cross_method_support": cross_ok, + "receiver_context_support": context_ok, + "support_count": support_count, + "evidence_class": evidence_class, + } + ) + return pd.DataFrame(rows) + + +def make_evidence_figure(evidence: pd.DataFrame, output_dir: Path) -> None: + support_cols = [ + "expression_support", + "spatial_abundance_null_support", + "matched_gene_control_support", + "component_ablation_support", + "cross_method_support", + "receiver_context_support", + ] + plot_df = evidence.set_index("axis_label")[support_cols].astype(float) + fig_height = max(4.2, 0.48 * len(plot_df) + 1.6) + fig, ax = plt.subplots(figsize=(11, fig_height)) + im = ax.imshow(plot_df.to_numpy(), aspect="auto", cmap="viridis", vmin=0, vmax=1) + ax.set_xticks(np.arange(len(support_cols))) + ax.set_xticklabels( + [ + "Expression\nspecificity", + "Spatial\nnull", + "Matched-gene\ncontrol", + "Component\nablation", + "Cross-method\nsupport", + "Receiver\ncontext", + ], + rotation=0, + ha="center", + fontsize=9, + ) + ax.set_yticks(np.arange(len(plot_df))) + ax.set_yticklabels(plot_df.index, fontsize=9) + ax.set_title("TopoLink-CCI validation evidence matrix", fontsize=13, weight="bold") + for i in range(plot_df.shape[0]): + for j in range(plot_df.shape[1]): + ax.text(j, i, "✓" if plot_df.iat[i, j] >= 0.5 else "", ha="center", va="center", color="white", fontsize=12) + cbar = fig.colorbar(im, ax=ax, fraction=0.025, pad=0.02) + cbar.set_label("Evidence present", rotation=270, labelpad=15) + fig.tight_layout() + fig.savefig(output_dir / "topolink_cci_validation_figure.png", dpi=300) + fig.savefig(output_dir / "topolink_cci_validation_figure.pdf") + plt.close(fig) + + +def markdown_table(df: pd.DataFrame, *, floatfmt: str = ".3g") -> str: + try: + return df.to_markdown(index=False, floatfmt=floatfmt) + except Exception: + return df.to_csv(sep="\t", index=False) + + +def write_report(evidence: pd.DataFrame, controls: pd.DataFrame, output_dir: Path) -> None: + report = output_dir / "topolink_cci_validation_scoreboard.md" + strong = evidence[evidence["evidence_class"] == "strong"] + moderate = evidence[evidence["evidence_class"] == "moderate"] + with report.open("w", encoding="utf-8") as handle: + handle.write("# TopoLink-CCI validation evidence scoreboard\n\n") + handle.write( + "This PDC run applies the computational false-positive-control logic used by classic CCC/LR papers: " + "expression specificity, spatial/label nulls, matched-gene controls, component ablation, " + "cross-method triangulation, and receiver-context support. It is computational evidence, not wet-lab proof.\n\n" + ) + handle.write("## Evidence classes\n\n") + handle.write(f"- Strong axes: {len(strong)}\n") + handle.write(f"- Moderate axes: {len(moderate)}\n") + handle.write(f"- Hypothesis-only axes: {int((evidence['evidence_class'] == 'hypothesis_only').sum())}\n\n") + cols = [ + "axis_label", + "biology_label", + "CCI_score", + "global_rank", + "evidence_class", + "support_count", + "cross_method_same_lr_count", + "matched_gene_percentile", + "cross_edge_enrichment_z", + "max_rank_after_component_removal", + ] + handle.write(markdown_table(evidence[cols], floatfmt=".3g")) + handle.write("\n\n") + handle.write("## Control interpretation\n\n") + handle.write( + "- `spatial_abundance_null`: compares observed sender-receiver graph edges with a label-abundance null; " + "it is conservative about exact geometry but catches cell-type-pair edge enrichment.\n" + ) + handle.write( + "- `matched_gene_control`: compares CCI sender-receiver expression specificity with genes matched by global mean and detection.\n" + ) + handle.write( + "- `lr_label_permutation`: reports where the candidate ranks within the same sender-receiver cell-type pair and within the same CCI pair across cell-type pairs.\n" + ) + handle.write( + "- `component_ablation`: recomputes geometric-mean LR scores after removing one pyXenium component at a time.\n\n" + ) + handle.write("## References to validation patterns\n\n") + handle.write( + "- CellPhoneDB: curated LR database, complex filtering, and cell-label permutation specificity.\n" + "- CellChat: mass-action communication probability, curated cofactors/complexes, and label permutation.\n" + "- NicheNet: downstream receiver target-gene support rather than co-expression alone.\n" + "- stLearn/SpatialDM/Squidpy: spatially constrained LR evidence and permutation/random-pair controls.\n" + "- LIANA benchmark: multi-method consensus and rank aggregation because no single LR score is ground truth.\n" + ) + controls.to_csv(output_dir / "topolink_cci_false_positive_controls.tsv", sep="\t", index=False) + + +def build_controls_table( + spatial: pd.DataFrame, + matched: pd.DataFrame, + ablation: pd.DataFrame, +) -> pd.DataFrame: + rows: list[dict[str, Any]] = [] + for row in spatial.itertuples(index=False): + rows.append( + { + "axis_id": row.axis_id, + "control_type": "spatial_abundance_null", + "observed": row.observed_cross_edge_count, + "expected_or_control_mean": row.expected_cross_edge_count_abundance_null, + "z_or_rank": row.cross_edge_enrichment_z, + "p_or_percentile": row.cross_edge_enrichment_p_approx, + "note": "cell-type-label abundance null for graph edge count", + } + ) + rows.append( + { + "axis_id": row.axis_id, + "control_type": "lr_label_permutation_same_sender_receiver", + "observed": row.within_sender_receiver_rank, + "expected_or_control_mean": row.within_sender_receiver_n, + "z_or_rank": row.within_sender_receiver_rank, + "p_or_percentile": row.within_sender_receiver_percentile, + "note": "rank percentile against all CCI pairs in the same sender-receiver cell-type pair", + } + ) + rows.append( + { + "axis_id": row.axis_id, + "control_type": "lr_label_permutation_same_lr_pair", + "observed": row.within_lr_pair_rank, + "expected_or_control_mean": row.within_lr_pair_n, + "z_or_rank": row.within_lr_pair_rank, + "p_or_percentile": row.within_lr_pair_percentile, + "note": "rank percentile for the same CCI pair across cell-type pairs", + } + ) + for row in matched.itertuples(index=False): + rows.append( + { + "axis_id": row.axis_id, + "control_type": "matched_gene_expression_control", + "observed": getattr(row, "observed_expression_specificity_score", np.nan), + "expected_or_control_mean": getattr(row, "control_mean", np.nan), + "z_or_rank": getattr(row, "matched_gene_z", np.nan), + "p_or_percentile": getattr(row, "matched_gene_percentile", np.nan), + "note": "matched by global mean expression and detection fraction", + } + ) + for axis_id, grp in ablation.groupby("axis_id"): + rows.append( + { + "axis_id": axis_id, + "control_type": "component_ablation_max_rank", + "observed": int(grp["rank_without_component"].max()), + "expected_or_control_mean": int(grp["rank_without_component"].min()), + "z_or_rank": int(grp["rank_without_component"].max()), + "p_or_percentile": np.nan, + "note": "worst and best rank after removing one score component", + } + ) + return pd.DataFrame(rows) + + +def run(args: argparse.Namespace) -> None: + started = time.time() + root = Path(args.root) + output_dir = Path(args.output_dir) if args.output_dir else root / "runs" / "validation" / "topolink_cci_false_positive_controls" + output_dir.mkdir(parents=True, exist_ok=True) + (output_dir / "tables").mkdir(exist_ok=True) + (output_dir / "figures").mkdir(exist_ok=True) + + params = vars(args).copy() + params["root"] = str(root) + params["output_dir"] = str(output_dir) + with (output_dir / "params.json").open("w", encoding="utf-8") as handle: + json.dump(params, handle, indent=2) + + manifest = load_manifest(root) + scores = read_scores(root) + targets = find_target_rows(scores) + ablation = component_ablation(scores, targets) + + genes, meta, matrix = load_bundle_expression(manifest) + expr_summary, mean_by_celltype, det_by_celltype, gene_to_index = summarize_expression(genes, meta, matrix) + expr = expression_specificity(targets, meta, mean_by_celltype, det_by_celltype, gene_to_index) + matched = matched_gene_controls( + targets, + meta, + mean_by_celltype, + det_by_celltype, + gene_to_index, + n_controls=args.n_matched_controls, + seed=args.seed, + ) + spatial = spatial_abundance_null(scores, targets, meta) + cross_summary, cross_detail = cross_method_support(root, targets) + receiver_context = receiver_panel_support(targets, meta, mean_by_celltype, gene_to_index) + + ablation_summary = ( + ablation.groupby("axis_id")["rank_without_component"] + .agg(max_rank_after_component_removal="max", min_rank_after_component_removal="min") + .reset_index() + ) + evidence = ( + targets[ + [ + "axis_id", + "biology_label", + "ligand", + "receptor", + "sender_celltype", + "receiver_celltype", + "CCI_score", + "global_rank", + *COMPONENTS, + "cross_edge_count", + ] + ] + .merge(expr, on=["axis_id", "ligand", "receptor"], how="left") + .merge(spatial, on="axis_id", how="left") + .merge(matched, on="axis_id", how="left") + .merge(ablation_summary, on="axis_id", how="left") + .merge(cross_summary, on="axis_id", how="left") + .merge(receiver_context, on="axis_id", how="left") + ) + class_df = classify_evidence(evidence) + evidence = evidence.merge(class_df, on="axis_id", how="left") + evidence["axis_label"] = evidence["ligand"] + "-" + evidence["receptor"] + "\n" + evidence["sender_celltype"] + " -> " + evidence["receiver_celltype"] + evidence = evidence.sort_values("CCI_score", ascending=False, kind="mergesort") + + controls = build_controls_table(spatial, matched, ablation) + tables = output_dir / "tables" + figures = output_dir / "figures" + evidence.to_csv(tables / "topolink_cci_validation_evidence.tsv", sep="\t", index=False) + controls.to_csv(tables / "topolink_cci_false_positive_controls.tsv", sep="\t", index=False) + ablation.to_csv(tables / "topolink_cci_component_ablation.tsv", sep="\t", index=False) + expr_summary.to_csv(tables / "topolink_cci_expression_gene_specificity.tsv", sep="\t", index=False) + matched.to_csv(tables / "topolink_cci_matched_gene_controls.tsv", sep="\t", index=False) + spatial.to_csv(tables / "topolink_cci_spatial_null_summary.tsv", sep="\t", index=False) + cross_detail.to_csv(tables / "topolink_cci_cross_method_support_detail.tsv", sep="\t", index=False) + + make_evidence_figure(evidence, figures) + write_report(evidence, controls, output_dir) + + summary = { + "status": "success", + "runtime_seconds": round(time.time() - started, 3), + "n_scores": int(len(scores)), + "n_target_axes": int(len(targets)), + "target_axes": evidence[["axis_id", "evidence_class", "support_count"]].to_dict(orient="records"), + "outputs": { + "evidence": str(tables / "topolink_cci_validation_evidence.tsv"), + "controls": str(tables / "topolink_cci_false_positive_controls.tsv"), + "scoreboard": str(output_dir / "topolink_cci_validation_scoreboard.md"), + "figure": str(figures / "topolink_cci_validation_figure.png"), + }, + } + with (output_dir / "run_summary.json").open("w", encoding="utf-8") as handle: + json.dump(summary, handle, indent=2) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description="Build TopoLink-CCI computational validation evidence on PDC.") + parser.add_argument("--root", default=str(DEFAULT_ROOT), help="PDC benchmark root.") + parser.add_argument("--output-dir", default=None, help="Output directory. Defaults under ROOT/runs/validation.") + parser.add_argument("--n-matched-controls", type=int, default=250, help="Matched random gene-pair controls per target axis.") + parser.add_argument("--seed", type=int, default=20260428) + return parser.parse_args() + + +if __name__ == "__main__": + run(parse_args()) diff --git a/benchmarking/cci_2026_atera/scripts/topolink_cci_validation_v2.py b/benchmarking/cci_2026_atera/scripts/topolink_cci_validation_v2.py new file mode 100644 index 0000000..5517f6f --- /dev/null +++ b/benchmarking/cci_2026_atera/scripts/topolink_cci_validation_v2.py @@ -0,0 +1,910 @@ +from __future__ import annotations + +import argparse +import json +import math +import time +from pathlib import Path +from typing import Any + +import matplotlib + +matplotlib.use("Agg") +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +from scipy.spatial import cKDTree +from scipy.stats import spearmanr + +from topolink_cci_validation_framework import ( + COMPONENTS, + TARGET_AXES, + TargetAxis, + build_controls_table, + component_ablation, + cross_method_support, + expression_specificity, + find_target_rows, + geometric_mean, + load_bundle_expression, + load_manifest, + markdown_table, + matched_gene_controls, + qnorm_sf, + read_scores, + receiver_panel_support, + spatial_abundance_null, + summarize_expression, +) + + +DEFAULT_ROOT = Path("/data/taobo.hu/pyxenium_cci_benchmark_2026-04") +RBC_PLATELET_MARKERS = ("PPBP", "PF4", "ITGA2B", "GP1BA", "HBB", "HBA1", "HBA2") +ENDOTHELIAL_MARKERS = ("PECAM1", "EMCN", "CDH5", "KDR", "FLT1", "MMRN2", "CLEC14A", "VWF") +HIGH_SCORE_NONCLASSIC_CONTROLS = ( + ("GNAS", "ADCY1", "11q13 Invasive Tumor Cells", "11q13 Invasive Tumor Cells"), + ("CDH1", "IGF1R", "Basal-like DCIS Cells", "Basal-like DCIS Cells"), + ("DSC3", "DSG3", "Basal-like DCIS Cells", "Basal-like DCIS Cells"), +) + + +def bh_fdr(pvalues: pd.Series) -> pd.Series: + arr = pd.to_numeric(pvalues, errors="coerce").to_numpy(dtype=float) + out = np.full(len(arr), np.nan) + valid = np.where(np.isfinite(arr))[0] + if len(valid) == 0: + return pd.Series(out, index=pvalues.index) + order = valid[np.argsort(arr[valid])] + ranked = arr[order] * len(valid) / np.arange(1, len(valid) + 1) + ranked = np.minimum.accumulate(ranked[::-1])[::-1] + out[order] = np.minimum(ranked, 1.0) + return pd.Series(out, index=pvalues.index) + + +def cell_type_codes(meta: pd.DataFrame) -> tuple[pd.Categorical, dict[str, np.ndarray]]: + cats = pd.Categorical(meta["cell_type"].astype(str)) + indices = {str(cat): np.where(cats.codes == i)[0] for i, cat in enumerate(cats.categories)} + return cats, indices + + +def dense_gene_cache(matrix, gene_to_index: dict[str, int], genes: list[str]) -> dict[str, np.ndarray]: + cache: dict[str, np.ndarray] = {} + for gene in sorted({g.upper() for g in genes if g and g.upper() in gene_to_index}): + cache[gene] = np.asarray(matrix.getrow(gene_to_index[gene]).toarray()).ravel().astype(np.float32) + return cache + + +def row_for_gene(cache: dict[str, np.ndarray], gene: str) -> np.ndarray | None: + return cache.get(str(gene).upper()) + + +def empirical_p_greater(observed: float, null: np.ndarray) -> float: + if len(null) == 0 or not np.isfinite(observed): + return float("nan") + return float((np.count_nonzero(null >= observed) + 1) / (len(null) + 1)) + + +def empirical_p_less(observed: float, null: np.ndarray) -> float: + if len(null) == 0 or not np.isfinite(observed): + return float("nan") + return float((np.count_nonzero(null <= observed) + 1) / (len(null) + 1)) + + +def build_spatial_edges( + coords: np.ndarray, + sender_indices: np.ndarray, + receiver_indices: np.ndarray, + *, + k: int, +) -> tuple[np.ndarray, np.ndarray, np.ndarray]: + if len(sender_indices) == 0 or len(receiver_indices) == 0: + return np.array([], dtype=int), np.array([], dtype=int), np.array([], dtype=float) + same_pool = np.array_equal(sender_indices, receiver_indices) + query_k = min(len(receiver_indices), k + 1 if same_pool else k) + tree = cKDTree(coords[receiver_indices]) + distances, neighbor_pos = tree.query(coords[sender_indices], k=query_k) + distances = np.atleast_2d(distances) + neighbor_pos = np.atleast_2d(neighbor_pos) + if distances.shape[0] != len(sender_indices): + distances = distances.T + neighbor_pos = neighbor_pos.T + edge_s: list[np.ndarray] = [] + edge_r: list[np.ndarray] = [] + edge_d: list[np.ndarray] = [] + for i, sender in enumerate(sender_indices): + rec = receiver_indices[neighbor_pos[i]] + dist = distances[i] + mask = np.isfinite(dist) + if same_pool: + mask &= rec != sender + rec = rec[mask][:k] + dist = dist[mask][:k] + if len(rec): + edge_s.append(np.repeat(sender, len(rec))) + edge_r.append(rec) + edge_d.append(dist) + if not edge_s: + return np.array([], dtype=int), np.array([], dtype=int), np.array([], dtype=float) + return np.concatenate(edge_s), np.concatenate(edge_r), np.concatenate(edge_d) + + +def nearest_pool( + gene_idx: int, + global_mean: np.ndarray, + global_det: np.ndarray, + protected: set[int], + *, + pool_size: int = 400, +) -> np.ndarray: + all_indices = np.arange(len(global_mean)) + distance = np.abs(np.log1p(global_mean) - np.log1p(global_mean[gene_idx])) + distance += np.abs(global_det - global_det[gene_idx]) + if protected: + distance[list(protected)] = np.inf + distance[gene_idx] = np.inf + valid = all_indices[np.isfinite(distance)] + if len(valid) == 0: + return np.array([], dtype=int) + ordered = valid[np.argsort(distance[valid])] + return ordered[: min(pool_size, len(ordered))] + + +def global_gene_summaries(mean_by_celltype: np.ndarray, det_by_celltype: np.ndarray, meta: pd.DataFrame) -> tuple[np.ndarray, np.ndarray]: + cats = pd.Categorical(meta["cell_type"].astype(str)) + sizes = np.asarray(pd.Series(cats).value_counts(sort=False), dtype=float) + weights = sizes / max(float(sizes.sum()), 1.0) + return mean_by_celltype @ weights, det_by_celltype @ weights + + +def cell_label_permutation( + targets: pd.DataFrame, + meta: pd.DataFrame, + gene_cache: dict[str, np.ndarray], + *, + n_permutations: int, + seed: int, +) -> pd.DataFrame: + rng = np.random.default_rng(seed) + _, indices = cell_type_codes(meta) + n_cells = len(meta) + rows: list[dict[str, Any]] = [] + for row in targets.itertuples(index=False): + lig = row_for_gene(gene_cache, row.ligand) + rec = row_for_gene(gene_cache, row.receptor) + sender_idx = indices.get(row.sender_celltype, np.array([], dtype=int)) + receiver_idx = indices.get(row.receiver_celltype, np.array([], dtype=int)) + if lig is None or rec is None or len(sender_idx) == 0 or len(receiver_idx) == 0: + rows.append({"axis_id": row.axis_id, "cell_label_perm_status": "missing"}) + continue + observed = float(np.mean(lig[sender_idx]) * np.mean(rec[receiver_idx])) + null = np.empty(n_permutations, dtype=float) + for i in range(n_permutations): + s = rng.choice(n_cells, size=len(sender_idx), replace=False) + r = rng.choice(n_cells, size=len(receiver_idx), replace=False) + null[i] = float(np.mean(lig[s]) * np.mean(rec[r])) + rows.append( + { + "axis_id": row.axis_id, + "cell_label_perm_status": "success", + "cell_label_comm_prob": observed, + "cell_label_perm_mean": float(np.mean(null)), + "cell_label_perm_sd": float(np.std(null, ddof=1)), + "cell_label_perm_z": float((observed - np.mean(null)) / max(float(np.std(null, ddof=1)), 1e-12)), + "cell_label_perm_p": empirical_p_greater(observed, null), + "cell_label_perm_n": n_permutations, + } + ) + out = pd.DataFrame(rows) + out["cell_label_perm_fdr"] = bh_fdr(out.get("cell_label_perm_p", pd.Series(dtype=float))) + return out + + +def spatial_neighborhood_controls( + targets: pd.DataFrame, + meta: pd.DataFrame, + matrix, + mean_by_celltype: np.ndarray, + det_by_celltype: np.ndarray, + gene_to_index: dict[str, int], + gene_cache: dict[str, np.ndarray], + *, + k_neighbors: int, + n_permutations: int, + n_matched_pairs: int, + seed: int, +) -> tuple[pd.DataFrame, pd.DataFrame]: + rng = np.random.default_rng(seed) + _, indices = cell_type_codes(meta) + coords = meta[["x", "y"]].to_numpy(dtype=float) + global_mean, global_det = global_gene_summaries(mean_by_celltype, det_by_celltype, meta) + protected = {gene_to_index[g.upper()] for axis in TARGET_AXES for g in (axis.ligand, axis.receptor) if g.upper() in gene_to_index} + rows: list[dict[str, Any]] = [] + edge_rows: list[dict[str, Any]] = [] + local_cache = dict(gene_cache) + + def get_gene_row_by_idx(idx: int) -> np.ndarray: + symbol = f"__idx_{idx}" + if symbol not in local_cache: + local_cache[symbol] = np.asarray(matrix.getrow(idx).toarray()).ravel().astype(np.float32) + return local_cache[symbol] + + for row in targets.itertuples(index=False): + lig = row_for_gene(local_cache, row.ligand) + rec = row_for_gene(local_cache, row.receptor) + sender_idx = indices.get(row.sender_celltype, np.array([], dtype=int)) + receiver_idx = indices.get(row.receiver_celltype, np.array([], dtype=int)) + if lig is None or rec is None or len(sender_idx) == 0 or len(receiver_idx) == 0: + rows.append({"axis_id": row.axis_id, "spatial_neighborhood_status": "missing"}) + continue + edge_s, edge_r, edge_d = build_spatial_edges(coords, sender_idx, receiver_idx, k=k_neighbors) + if len(edge_s) == 0: + rows.append({"axis_id": row.axis_id, "spatial_neighborhood_status": "no_edges"}) + continue + edge_product = lig[edge_s] * rec[edge_r] + observed = float(np.mean(edge_product)) + active_fraction = float(np.mean((lig[edge_s] > 0) & (rec[edge_r] > 0))) + + perm_null = np.empty(n_permutations, dtype=float) + for i in range(n_permutations): + shuffled_r = rng.permutation(edge_r) + perm_null[i] = float(np.mean(lig[edge_s] * rec[shuffled_r])) + + lig_idx = gene_to_index.get(str(row.ligand).upper()) + rec_idx = gene_to_index.get(str(row.receptor).upper()) + matched_null: list[float] = [] + if lig_idx is not None and rec_idx is not None: + lig_pool = nearest_pool(lig_idx, global_mean, global_det, protected) + rec_pool = nearest_pool(rec_idx, global_mean, global_det, protected) + if len(lig_pool) and len(rec_pool): + lig_sample = rng.choice(lig_pool, size=n_matched_pairs, replace=len(lig_pool) < n_matched_pairs) + rec_sample = rng.choice(rec_pool, size=n_matched_pairs, replace=len(rec_pool) < n_matched_pairs) + for lidx, ridx in zip(lig_sample, rec_sample): + lrow = get_gene_row_by_idx(int(lidx)) + rrow = get_gene_row_by_idx(int(ridx)) + matched_null.append(float(np.mean(lrow[edge_s] * rrow[edge_r]))) + matched_arr = np.asarray(matched_null, dtype=float) + rows.append( + { + "axis_id": row.axis_id, + "spatial_neighborhood_status": "success", + "spatial_edge_count": int(len(edge_s)), + "spatial_edge_mean_distance": float(np.mean(edge_d)), + "spatial_lr_edge_score": observed, + "spatial_lr_active_edge_fraction": active_fraction, + "spatial_perm_mean": float(np.mean(perm_null)), + "spatial_perm_sd": float(np.std(perm_null, ddof=1)), + "spatial_perm_z": float((observed - np.mean(perm_null)) / max(float(np.std(perm_null, ddof=1)), 1e-12)), + "spatial_perm_p": empirical_p_greater(observed, perm_null), + "spatial_matched_gene_mean": float(np.mean(matched_arr)) if len(matched_arr) else np.nan, + "spatial_matched_gene_sd": float(np.std(matched_arr, ddof=1)) if len(matched_arr) > 1 else np.nan, + "spatial_matched_gene_z": float((observed - np.mean(matched_arr)) / max(float(np.std(matched_arr, ddof=1)), 1e-12)) if len(matched_arr) > 1 else np.nan, + "spatial_matched_gene_p": empirical_p_greater(observed, matched_arr) if len(matched_arr) else np.nan, + } + ) + edge_rows.append( + { + "axis_id": row.axis_id, + "edge_count": int(len(edge_s)), + "mean_distance": float(np.mean(edge_d)), + "median_distance": float(np.median(edge_d)), + "p90_distance": float(np.quantile(edge_d, 0.9)), + } + ) + out = pd.DataFrame(rows) + out["spatial_null_fdr"] = bh_fdr(out.get("spatial_perm_p", pd.Series(dtype=float))) + out["spatial_matched_gene_fdr"] = bh_fdr(out.get("spatial_matched_gene_p", pd.Series(dtype=float))) + return out, pd.DataFrame(edge_rows) + + +def downstream_target_support( + targets: pd.DataFrame, + meta: pd.DataFrame, + matrix, + mean_by_celltype: np.ndarray, + det_by_celltype: np.ndarray, + gene_to_index: dict[str, int], + *, + n_permutations: int, + seed: int, +) -> pd.DataFrame: + rng = np.random.default_rng(seed) + _, indices = cell_type_codes(meta) + global_mean, global_det = global_gene_summaries(mean_by_celltype, det_by_celltype, meta) + protected = {idx for idx in gene_to_index.values() if idx < len(global_mean)} + axis_to_config = {axis.axis_id: axis for axis in TARGET_AXES} + rows: list[dict[str, Any]] = [] + for row in targets.itertuples(index=False): + axis = axis_to_config[row.axis_id] + receiver_idx = indices.get(row.receiver_celltype, np.array([], dtype=int)) + present = [gene_to_index[g.upper()] for g in axis.target_panel if g.upper() in gene_to_index] + if len(receiver_idx) == 0 or not present: + rows.append({"axis_id": row.axis_id, "downstream_status": "missing"}) + continue + gene_scores = [] + null_scores: list[float] = [] + for gene_idx in present: + expr = np.asarray(matrix.getrow(gene_idx).toarray()).ravel().astype(np.float32) + observed = float(np.mean(expr[receiver_idx]) / max(float(np.mean(expr) + 1e-12), 1e-12)) + gene_scores.append(observed) + pool = nearest_pool(gene_idx, global_mean, global_det, protected=set(), pool_size=800) + if len(pool): + sample = rng.choice(pool, size=n_permutations, replace=len(pool) < n_permutations) + for idx in sample: + ctrl = np.asarray(matrix.getrow(int(idx)).toarray()).ravel().astype(np.float32) + null_scores.append(float(np.mean(ctrl[receiver_idx]) / max(float(np.mean(ctrl) + 1e-12), 1e-12))) + observed_panel = float(np.mean(gene_scores)) + null_arr = np.asarray(null_scores, dtype=float) + rows.append( + { + "axis_id": row.axis_id, + "downstream_status": "success", + "downstream_target_genes_present": len(present), + "downstream_target_score": observed_panel, + "downstream_target_null_mean": float(np.mean(null_arr)) if len(null_arr) else np.nan, + "downstream_target_null_sd": float(np.std(null_arr, ddof=1)) if len(null_arr) > 1 else np.nan, + "downstream_target_z": float((observed_panel - np.mean(null_arr)) / max(float(np.std(null_arr, ddof=1)), 1e-12)) if len(null_arr) > 1 else np.nan, + "downstream_target_p": empirical_p_greater(observed_panel, null_arr) if len(null_arr) else np.nan, + "downstream_target_gene_panel": ",".join([g for g in axis.target_panel if g.upper() in gene_to_index]), + } + ) + out = pd.DataFrame(rows) + out["downstream_target_fdr"] = bh_fdr(out.get("downstream_target_p", pd.Series(dtype=float))) + return out + + +def functional_received_signal_support( + targets: pd.DataFrame, + meta: pd.DataFrame, + matrix, + gene_to_index: dict[str, int], + gene_cache: dict[str, np.ndarray], + *, + k_neighbors: int, +) -> pd.DataFrame: + _, indices = cell_type_codes(meta) + coords = meta[["x", "y"]].to_numpy(dtype=float) + axis_to_config = {axis.axis_id: axis for axis in TARGET_AXES} + rows: list[dict[str, Any]] = [] + panel_cache: dict[int, np.ndarray] = {} + + def gene_row(idx: int) -> np.ndarray: + if idx not in panel_cache: + panel_cache[idx] = np.asarray(matrix.getrow(idx).toarray()).ravel().astype(np.float32) + return panel_cache[idx] + + for row in targets.itertuples(index=False): + axis = axis_to_config[row.axis_id] + lig = row_for_gene(gene_cache, row.ligand) + rec = row_for_gene(gene_cache, row.receptor) + sender_idx = indices.get(row.sender_celltype, np.array([], dtype=int)) + receiver_idx = indices.get(row.receiver_celltype, np.array([], dtype=int)) + present = [gene_to_index[g.upper()] for g in axis.target_panel if g.upper() in gene_to_index] + if lig is None or rec is None or len(sender_idx) == 0 or len(receiver_idx) == 0 or not present: + rows.append({"axis_id": row.axis_id, "functional_signal_status": "missing"}) + continue + edge_s, edge_r, _ = build_spatial_edges(coords, receiver_idx, sender_idx, k=k_neighbors) + if len(edge_s) == 0: + rows.append({"axis_id": row.axis_id, "functional_signal_status": "no_edges"}) + continue + # build received signal on receiver cells: receptor level multiplied by local sender ligand average + receiver_to_values: dict[int, list[float]] = {} + for rec_cell, sender_cell in zip(edge_s, edge_r): + receiver_to_values.setdefault(int(rec_cell), []).append(float(lig[sender_cell])) + receiver_cells = np.array(sorted(receiver_to_values), dtype=int) + sender_lig_mean = np.array([np.mean(receiver_to_values[int(cell)]) for cell in receiver_cells], dtype=float) + signal = rec[receiver_cells] * sender_lig_mean + panel_expr = np.vstack([gene_row(idx)[receiver_cells] for idx in present]) + panel_score = np.mean(np.log1p(panel_expr), axis=0) + if np.std(signal) == 0 or np.std(panel_score) == 0: + rho = np.nan + p = np.nan + else: + rho, p = spearmanr(signal, panel_score) + top = signal >= np.quantile(signal, 0.8) + bottom = signal <= np.quantile(signal, 0.2) + rows.append( + { + "axis_id": row.axis_id, + "functional_signal_status": "success", + "received_signal_n_cells": int(len(receiver_cells)), + "received_signal_target_spearman": float(rho) if np.isfinite(rho) else np.nan, + "received_signal_target_p": float(p) if np.isfinite(p) else np.nan, + "received_signal_top_vs_bottom_target_delta": float(np.mean(panel_score[top]) - np.mean(panel_score[bottom])) if np.any(top) and np.any(bottom) else np.nan, + } + ) + out = pd.DataFrame(rows) + out["received_signal_target_fdr"] = bh_fdr(out.get("received_signal_target_p", pd.Series(dtype=float))) + return out + + +def contamination_controls( + targets: pd.DataFrame, + meta: pd.DataFrame, + matrix, + gene_to_index: dict[str, int], +) -> pd.DataFrame: + _, indices = cell_type_codes(meta) + rows: list[dict[str, Any]] = [] + + def marker_score(markers: tuple[str, ...], cells: np.ndarray) -> tuple[float, float, int]: + present = [gene_to_index[m.upper()] for m in markers if m.upper() in gene_to_index] + if not present or len(cells) == 0: + return np.nan, np.nan, 0 + means = [] + dets = [] + for idx in present: + expr = np.asarray(matrix.getrow(idx).toarray()).ravel().astype(np.float32) + means.append(float(np.mean(expr[cells]))) + dets.append(float(np.mean(expr[cells] > 0))) + return float(np.mean(means)), float(np.mean(dets)), len(present) + + for row in targets.itertuples(index=False): + cells = np.unique( + np.concatenate( + [ + indices.get(row.sender_celltype, np.array([], dtype=int)), + indices.get(row.receiver_celltype, np.array([], dtype=int)), + ] + ) + ) + cont_mean, cont_det, cont_n = marker_score(RBC_PLATELET_MARKERS, cells) + endo_mean, endo_det, endo_n = marker_score(ENDOTHELIAL_MARKERS, cells) + ratio = cont_mean / max(endo_mean, 1e-12) if np.isfinite(cont_mean) and np.isfinite(endo_mean) else np.nan + flag = bool(np.isfinite(ratio) and ratio > 0.35 and np.isfinite(cont_det) and cont_det > 0.10) + rows.append( + { + "axis_id": row.axis_id, + "contamination_marker_mean": cont_mean, + "contamination_marker_detection": cont_det, + "contamination_marker_n": cont_n, + "endothelial_marker_mean": endo_mean, + "endothelial_marker_detection": endo_det, + "endothelial_marker_n": endo_n, + "contamination_to_endothelial_ratio": ratio, + "contamination_flag": flag, + } + ) + return pd.DataFrame(rows) + + +def bootstrap_stability( + targets: pd.DataFrame, + meta: pd.DataFrame, + gene_cache: dict[str, np.ndarray], + *, + n_bootstraps: int, + fraction: float, + seed: int, +) -> tuple[pd.DataFrame, pd.DataFrame]: + rng = np.random.default_rng(seed) + cats, indices = cell_type_codes(meta) + repeats: list[dict[str, Any]] = [] + summary: list[dict[str, Any]] = [] + for repeat in range(1, n_bootstraps + 1): + sampled_by_type: dict[str, np.ndarray] = {} + for cell_type, idx in indices.items(): + n = max(1, int(round(len(idx) * fraction))) + sampled_by_type[cell_type] = rng.choice(idx, size=n, replace=False) + scores = [] + for row in targets.itertuples(index=False): + lig = row_for_gene(gene_cache, row.ligand) + rec = row_for_gene(gene_cache, row.receptor) + sidx = sampled_by_type.get(row.sender_celltype, np.array([], dtype=int)) + ridx = sampled_by_type.get(row.receiver_celltype, np.array([], dtype=int)) + if lig is None or rec is None or len(sidx) == 0 or len(ridx) == 0: + score = np.nan + else: + lig_sender = float(np.mean(lig[sidx]) / max(float(np.mean(lig) + 1e-12), 1e-12)) + rec_receiver = float(np.mean(rec[ridx]) / max(float(np.mean(rec) + 1e-12), 1e-12)) + lig_det = float(np.mean(lig[sidx] > 0)) + rec_det = float(np.mean(rec[ridx] > 0)) + score = float(geometric_mean(np.array([lig_sender, rec_receiver, lig_det, rec_det]))) + scores.append((row.axis_id, score)) + score_values = np.array([s for _, s in scores], dtype=float) + order = np.argsort(-np.nan_to_num(score_values, nan=-np.inf)) + rank_map = {scores[idx][0]: rank + 1 for rank, idx in enumerate(order)} + for axis_id, score in scores: + repeats.append({"axis_id": axis_id, "bootstrap_id": repeat, "bootstrap_validation_score": score, "bootstrap_rank": rank_map[axis_id]}) + repeat_df = pd.DataFrame(repeats) + for axis_id, grp in repeat_df.groupby("axis_id"): + summary.append( + { + "axis_id": axis_id, + "bootstrap_rank_median": float(np.median(grp["bootstrap_rank"])), + "bootstrap_rank_iqr": float(np.quantile(grp["bootstrap_rank"], 0.75) - np.quantile(grp["bootstrap_rank"], 0.25)), + "bootstrap_score_mean": float(np.mean(grp["bootstrap_validation_score"])), + "bootstrap_score_sd": float(np.std(grp["bootstrap_validation_score"], ddof=1)) if len(grp) > 1 else 0.0, + "bootstrap_n": int(len(grp)), + } + ) + return pd.DataFrame(summary), repeat_df + + +def classify_v2(evidence: pd.DataFrame) -> pd.DataFrame: + rows: list[dict[str, Any]] = [] + for row in evidence.itertuples(index=False): + expression_ok = bool(getattr(row, "ligand_sender_specificity_ratio", 0) >= 0.75 and getattr(row, "receptor_receiver_specificity_ratio", 0) >= 0.50) + label_perm_ok = bool(pd.notna(getattr(row, "cell_label_perm_fdr", np.nan)) and getattr(row, "cell_label_perm_fdr") <= 0.05) + spatial_ok = bool(pd.notna(getattr(row, "spatial_null_fdr", np.nan)) and getattr(row, "spatial_null_fdr") <= 0.10) + matched_ok = bool(pd.notna(getattr(row, "matched_gene_percentile", np.nan)) and getattr(row, "matched_gene_percentile") >= 0.90) + downstream_ok = bool(pd.notna(getattr(row, "downstream_target_fdr", np.nan)) and getattr(row, "downstream_target_fdr") <= 0.10) + functional_ok = bool( + ( + pd.notna(getattr(row, "received_signal_target_fdr", np.nan)) + and getattr(row, "received_signal_target_fdr") <= 0.10 + and getattr(row, "received_signal_target_spearman", 0) > 0 + ) + or (pd.notna(getattr(row, "received_signal_top_vs_bottom_target_delta", np.nan)) and getattr(row, "received_signal_top_vs_bottom_target_delta") > 0) + ) + cross_ok = bool(getattr(row, "cross_method_exact_count", 0) >= 1 or getattr(row, "cross_method_same_lr_count", 0) >= 2) + ablation_ok = bool(pd.notna(getattr(row, "max_rank_after_component_removal", np.nan)) and getattr(row, "max_rank_after_component_removal") <= 750) + bootstrap_ok = bool(pd.notna(getattr(row, "bootstrap_rank_iqr", np.nan)) and getattr(row, "bootstrap_rank_iqr") <= 2.0) + contamination_flag = bool(getattr(row, "contamination_flag", False)) + support_flags = { + "expression_specificity_support": expression_ok, + "cell_label_permutation_support": label_perm_ok, + "spatial_null_support": spatial_ok, + "matched_gene_control_support": matched_ok, + "downstream_target_support": downstream_ok, + "functional_received_signal_support": functional_ok, + "cross_method_support": cross_ok, + "component_ablation_support": ablation_ok, + "bootstrap_stability_support": bootstrap_ok, + } + support_count = int(sum(support_flags.values())) + if contamination_flag: + evidence_class = "artifact_risk" + elif support_count >= 5: + evidence_class = "strong" + elif support_count >= 3: + evidence_class = "moderate" + else: + evidence_class = "hypothesis_only" + interpretation = ( + f"{evidence_class}: {support_count}/9 computational evidence layers support the axis; " + f"contamination_flag={contamination_flag}." + ) + rows.append({"axis_id": row.axis_id, **support_flags, "support_count": support_count, "evidence_class": evidence_class, "interpretation_note": interpretation}) + return pd.DataFrame(rows) + + +def make_figures(evidence: pd.DataFrame, output_dir: Path) -> None: + figures = output_dir / "figures" + figures.mkdir(parents=True, exist_ok=True) + support_cols = [ + "expression_specificity_support", + "cell_label_permutation_support", + "spatial_null_support", + "matched_gene_control_support", + "downstream_target_support", + "functional_received_signal_support", + "cross_method_support", + "component_ablation_support", + "bootstrap_stability_support", + ] + label_df = evidence.set_index("axis_label")[support_cols].astype(float) + fig, ax = plt.subplots(figsize=(13.5, max(4.5, 0.55 * len(label_df) + 1.8))) + im = ax.imshow(label_df.to_numpy(), aspect="auto", cmap="YlGnBu", vmin=0, vmax=1) + ax.set_xticks(np.arange(len(support_cols))) + ax.set_xticklabels( + [ + "Expression", + "Label\nperm", + "Spatial\nnull", + "Matched\ngenes", + "Downstream", + "Received\nsignal", + "Cross\nmethod", + "Ablation", + "Bootstrap", + ], + fontsize=8, + ) + ax.set_yticks(np.arange(len(label_df))) + ax.set_yticklabels(label_df.index, fontsize=8) + ax.set_title("TopoLink-CCI validation v2: multi-layer false-positive controls", fontsize=13, weight="bold") + for i in range(label_df.shape[0]): + for j in range(label_df.shape[1]): + if label_df.iat[i, j] > 0: + ax.text(j, i, "✓", ha="center", va="center", color="black", fontsize=11) + fig.colorbar(im, ax=ax, fraction=0.025, pad=0.02) + fig.tight_layout() + fig.savefig(figures / "topolink_cci_validation_v2_evidence_matrix.png", dpi=300) + fig.savefig(figures / "topolink_cci_validation_v2_evidence_matrix.pdf") + plt.close(fig) + + fig, ax = plt.subplots(figsize=(8.5, 4.5)) + plot = evidence.sort_values("CCI_score", ascending=True) + colors = plot["evidence_class"].map({"strong": "#0f766e", "moderate": "#f59e0b", "hypothesis_only": "#64748b", "artifact_risk": "#dc2626"}).fillna("#64748b") + ax.barh(plot["ligand"] + "-" + plot["receptor"], plot["support_count"], color=colors) + ax.set_xlabel("Supported evidence layers (max 9)") + ax.set_xlim(0, 9) + ax.set_title("Validation support count by LR axis") + fig.tight_layout() + fig.savefig(figures / "topolink_cci_validation_v2_support_counts.png", dpi=300) + fig.savefig(figures / "topolink_cci_validation_v2_support_counts.pdf") + plt.close(fig) + + +def write_validation_cards(evidence: pd.DataFrame, output_dir: Path) -> None: + cards = output_dir / "reports" / "validation_cards" + cards.mkdir(parents=True, exist_ok=True) + for row in evidence.itertuples(index=False): + path = cards / f"{row.ligand}_{row.receptor}_{row.sender}_{row.receiver}.md".replace("/", "-").replace(" ", "_").replace(",", "") + with path.open("w", encoding="utf-8") as handle: + handle.write(f"# {row.ligand}-{row.receptor}: {row.sender} -> {row.receiver}\n\n") + handle.write(f"- Biology label: {row.biology_label}\n") + handle.write(f"- pyXenium CCI_score: {row.CCI_score:.6g}\n") + handle.write(f"- pyXenium rank: {int(row.pyxenium_rank)}\n") + handle.write(f"- Evidence class: {row.evidence_class}\n") + handle.write(f"- Supported layers: {int(row.support_count)}/9\n") + handle.write(f"- Interpretation: {row.interpretation_note}\n\n") + handle.write("## Key controls\n\n") + cols = [ + "cell_label_perm_fdr", + "spatial_null_fdr", + "matched_gene_z", + "matched_gene_percentile", + "downstream_target_score", + "downstream_target_fdr", + "received_signal_target_spearman", + "cross_method_exact_count", + "cross_method_same_lr_count", + "bootstrap_rank_median", + "bootstrap_rank_iqr", + "max_rank_after_component_removal", + "contamination_flag", + ] + for col in cols: + if hasattr(row, col): + handle.write(f"- `{col}`: {getattr(row, col)}\n") + handle.write("\nThis is computational support only; it does not prove protein-level binding or functional signaling.\n") + + +def write_report(evidence: pd.DataFrame, output_dir: Path) -> None: + reports = output_dir / "reports" + reports.mkdir(parents=True, exist_ok=True) + report = reports / "topolink_cci_validation_v2_report.md" + with report.open("w", encoding="utf-8") as handle: + handle.write("# TopoLink-CCI validation v2\n\n") + handle.write( + "This report applies the main computational false-positive controls used by classic LR/CCC papers to TopoLink-CCI axes. " + "The result should be read as computational validation, not wet-lab proof.\n\n" + ) + handle.write("## Summary\n\n") + counts = evidence["evidence_class"].value_counts().to_dict() + for cls in ["strong", "moderate", "hypothesis_only", "artifact_risk"]: + handle.write(f"- {cls}: {counts.get(cls, 0)}\n") + handle.write("\n") + cols = [ + "ligand", + "receptor", + "sender", + "receiver", + "CCI_score", + "pyxenium_rank", + "evidence_class", + "support_count", + "cell_label_perm_fdr", + "spatial_null_fdr", + "matched_gene_z", + "downstream_target_fdr", + "cross_method_same_lr_count", + "bootstrap_rank_median", + "contamination_flag", + ] + handle.write(markdown_table(evidence[cols], floatfmt=".3g")) + handle.write("\n\n## Evidence layers implemented\n\n") + handle.write("- CellPhoneDB/Squidpy-style cell-label permutation of CCI communication probability.\n") + handle.write("- CellChat-style sender/receiver group specificity and permutation significance.\n") + handle.write("- stLearn-style spatial-neighborhood LR co-expression plus matched-expression random gene pairs.\n") + handle.write("- SpatialDM-style spatial expression null based on CCI neighborhood coupling.\n") + handle.write("- NicheNet-style receiver target/pathway support using predefined biology panels.\n") + handle.write("- COMMOT/SpaTalk-style received-signal association with receiver target programs.\n") + handle.write("- LIANA-style cross-method consensus across completed benchmark methods.\n") + handle.write("- pyXenium component ablation and stratified bootstrap stability.\n") + handle.write("\n## Caveat\n\n") + handle.write("The framework reduces false-positive risk, but protein-level receptor binding, secretion, and functional causality require orthogonal experimental validation.\n") + + +def make_control_rows( + cell_perm: pd.DataFrame, + spatial: pd.DataFrame, + downstream: pd.DataFrame, + functional: pd.DataFrame, + bootstrap: pd.DataFrame, +) -> pd.DataFrame: + rows: list[dict[str, Any]] = [] + for df, control_name, value_cols in [ + (cell_perm, "cell_label_permutation", ["cell_label_comm_prob", "cell_label_perm_mean", "cell_label_perm_z", "cell_label_perm_p", "cell_label_perm_fdr"]), + (spatial, "spatial_neighborhood_permutation", ["spatial_lr_edge_score", "spatial_perm_mean", "spatial_perm_z", "spatial_perm_p", "spatial_null_fdr"]), + (spatial, "spatial_matched_gene_pairs", ["spatial_lr_edge_score", "spatial_matched_gene_mean", "spatial_matched_gene_z", "spatial_matched_gene_p", "spatial_matched_gene_fdr"]), + (downstream, "downstream_target_enrichment", ["downstream_target_score", "downstream_target_null_mean", "downstream_target_z", "downstream_target_p", "downstream_target_fdr"]), + (functional, "received_signal_target_correlation", ["received_signal_target_spearman", "received_signal_target_p", "received_signal_target_fdr", "received_signal_top_vs_bottom_target_delta"]), + (bootstrap, "bootstrap_stability", ["bootstrap_rank_median", "bootstrap_rank_iqr", "bootstrap_score_mean", "bootstrap_score_sd"]), + ]: + if df.empty: + continue + for row in df.itertuples(index=False): + item = {"axis_id": row.axis_id, "control_type": control_name} + for col in value_cols: + if hasattr(row, col): + item[col] = getattr(row, col) + rows.append(item) + return pd.DataFrame(rows) + + +def run(args: argparse.Namespace) -> None: + started = time.time() + root = Path(args.root) + output_dir = Path(args.output_dir) if args.output_dir else root / "runs" / "validation" / "topolink_cci_validation_v2" + tables = output_dir / "tables" + figures = output_dir / "figures" + reports = output_dir / "reports" + for folder in (output_dir, tables, figures, reports): + folder.mkdir(parents=True, exist_ok=True) + + with (output_dir / "params.json").open("w", encoding="utf-8") as handle: + json.dump(vars(args), handle, indent=2) + + manifest = load_manifest(root) + scores = read_scores(root) + if len(scores) != args.expected_score_rows: + raise RuntimeError(f"Expected {args.expected_score_rows} pyXenium rows, observed {len(scores)}") + targets = find_target_rows(scores) + targets = targets.rename(columns={"global_rank": "pyxenium_rank", "sender_celltype": "sender", "receiver_celltype": "receiver"}) + if not ((targets["ligand"] == "VWF") & (targets["receptor"] == "SELP") & (targets["pyxenium_rank"] == 1)).any(): + raise RuntimeError("VWF-SELP was not detected as pyXenium rank 1 in the selected target table.") + + # Rebuild the column names expected by the v1 helper functions. + helper_targets = targets.rename(columns={"pyxenium_rank": "global_rank", "sender": "sender_celltype", "receiver": "receiver_celltype"}) + + ablation = component_ablation(scores, helper_targets) + genes, meta, matrix = load_bundle_expression(manifest) + expr_summary, mean_by_celltype, det_by_celltype, gene_to_index = summarize_expression(genes, meta, matrix) + + all_needed_genes = sorted( + { + g + for axis in TARGET_AXES + for g in (axis.ligand, axis.receptor, *axis.target_panel, *RBC_PLATELET_MARKERS, *ENDOTHELIAL_MARKERS) + } + ) + gene_cache = dense_gene_cache(matrix, gene_to_index, all_needed_genes) + + expr = expression_specificity(helper_targets, meta, mean_by_celltype, det_by_celltype, gene_to_index) + matched = matched_gene_controls(helper_targets, meta, mean_by_celltype, det_by_celltype, gene_to_index, n_controls=args.n_matched_controls, seed=args.seed) + abundance_null = spatial_abundance_null(scores, helper_targets, meta) + cross_summary, cross_detail = cross_method_support(root, helper_targets) + receiver_context = receiver_panel_support(helper_targets, meta, mean_by_celltype, gene_to_index) + cell_perm = cell_label_permutation(helper_targets, meta, gene_cache, n_permutations=args.n_label_permutations, seed=args.seed + 1) + spatial, spatial_edges = spatial_neighborhood_controls( + helper_targets, + meta, + matrix, + mean_by_celltype, + det_by_celltype, + gene_to_index, + gene_cache, + k_neighbors=args.k_neighbors, + n_permutations=args.n_spatial_permutations, + n_matched_pairs=args.n_spatial_matched_pairs, + seed=args.seed + 2, + ) + downstream = downstream_target_support( + helper_targets, + meta, + matrix, + mean_by_celltype, + det_by_celltype, + gene_to_index, + n_permutations=args.n_downstream_permutations, + seed=args.seed + 3, + ) + functional = functional_received_signal_support(helper_targets, meta, matrix, gene_to_index, gene_cache, k_neighbors=args.k_neighbors) + contamination = contamination_controls(helper_targets, meta, matrix, gene_to_index) + bootstrap, bootstrap_repeats = bootstrap_stability( + helper_targets, + meta, + gene_cache, + n_bootstraps=args.n_bootstraps, + fraction=args.bootstrap_fraction, + seed=args.seed + 4, + ) + + ablation_summary = ( + ablation.groupby("axis_id")["rank_without_component"] + .agg(max_rank_after_ablation="max", min_rank_after_ablation="min") + .reset_index() + ) + evidence = ( + targets[ + [ + "axis_id", + "biology_label", + "ligand", + "receptor", + "sender", + "receiver", + "CCI_score", + "pyxenium_rank", + *COMPONENTS, + "cross_edge_count", + ] + ] + .merge(expr.rename(columns={"sender": "sender_expr_label", "receiver": "receiver_expr_label"}), on=["axis_id", "ligand", "receptor"], how="left") + .merge(abundance_null, on="axis_id", how="left") + .merge(matched, on="axis_id", how="left") + .merge(ablation_summary, on="axis_id", how="left") + .merge(cross_summary, on="axis_id", how="left") + .merge(receiver_context, on="axis_id", how="left") + .merge(cell_perm, on="axis_id", how="left") + .merge(spatial, on="axis_id", how="left") + .merge(downstream, on="axis_id", how="left") + .merge(functional, on="axis_id", how="left") + .merge(contamination, on="axis_id", how="left") + .merge(bootstrap, on="axis_id", how="left") + ) + classes = classify_v2(evidence) + evidence = evidence.merge(classes, on="axis_id", how="left") + evidence["axis_label"] = evidence["ligand"] + "-" + evidence["receptor"] + "\n" + evidence["sender"] + " -> " + evidence["receiver"] + evidence = evidence.sort_values("CCI_score", ascending=False, kind="mergesort") + + classic_controls = build_controls_table(abundance_null, matched, ablation) + v2_controls = make_control_rows(cell_perm, spatial, downstream, functional, bootstrap) + control_table = pd.concat([classic_controls, v2_controls], ignore_index=True, sort=False) + + evidence.to_csv(tables / "topolink_cci_validation_v2_evidence.tsv", sep="\t", index=False) + control_table.to_csv(tables / "topolink_cci_validation_v2_false_positive_controls.tsv", sep="\t", index=False) + cell_perm.to_csv(tables / "cell_label_permutation.tsv", sep="\t", index=False) + spatial.to_csv(tables / "spatial_neighborhood_controls.tsv", sep="\t", index=False) + spatial_edges.to_csv(tables / "spatial_edge_summary.tsv", sep="\t", index=False) + downstream.to_csv(tables / "downstream_target_support.tsv", sep="\t", index=False) + functional.to_csv(tables / "functional_received_signal_support.tsv", sep="\t", index=False) + contamination.to_csv(tables / "contamination_controls.tsv", sep="\t", index=False) + bootstrap.to_csv(tables / "bootstrap_stability_summary.tsv", sep="\t", index=False) + bootstrap_repeats.to_csv(tables / "bootstrap_stability_repeats.tsv", sep="\t", index=False) + cross_detail.to_csv(tables / "cross_method_support_detail.tsv", sep="\t", index=False) + expr_summary.to_csv(tables / "expression_gene_specificity.tsv", sep="\t", index=False) + ablation.to_csv(tables / "component_ablation.tsv", sep="\t", index=False) + + make_figures(evidence, output_dir) + write_report(evidence, output_dir) + write_validation_cards(evidence, output_dir) + + summary = { + "status": "success", + "runtime_seconds": round(time.time() - started, 3), + "n_scores": int(len(scores)), + "n_target_axes": int(len(evidence)), + "evidence_class_counts": evidence["evidence_class"].value_counts().to_dict(), + "outputs": { + "evidence": str(tables / "topolink_cci_validation_v2_evidence.tsv"), + "controls": str(tables / "topolink_cci_validation_v2_false_positive_controls.tsv"), + "report": str(reports / "topolink_cci_validation_v2_report.md"), + "figure": str(figures / "topolink_cci_validation_v2_evidence_matrix.png"), + }, + } + with (output_dir / "run_summary.json").open("w", encoding="utf-8") as handle: + json.dump(summary, handle, indent=2) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description="Run full TopoLink-CCI validation v2 false-positive controls.") + parser.add_argument("--root", default=str(DEFAULT_ROOT)) + parser.add_argument("--output-dir", default=None) + parser.add_argument("--expected-score-rows", type=int, default=1_319_600) + parser.add_argument("--n-label-permutations", type=int, default=500) + parser.add_argument("--n-spatial-permutations", type=int, default=300) + parser.add_argument("--n-spatial-matched-pairs", type=int, default=120) + parser.add_argument("--n-matched-controls", type=int, default=250) + parser.add_argument("--n-downstream-permutations", type=int, default=120) + parser.add_argument("--n-bootstraps", type=int, default=5) + parser.add_argument("--bootstrap-fraction", type=float, default=0.8) + parser.add_argument("--k-neighbors", type=int, default=10) + parser.add_argument("--seed", type=int, default=20260428) + return parser.parse_args() + + +if __name__ == "__main__": + run(parse_args()) diff --git a/benchmarking/cci_2026_atera/topolink_cci_classic_axes/figures/topolink_cci_classic_axes_top_axes.pdf b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/figures/topolink_cci_classic_axes_top_axes.pdf new file mode 100644 index 0000000000000000000000000000000000000000..666c0749f3fffc99eca9a8a1d0660527a7f6f3dd GIT binary patch literal 30949 zcmb@u1z1#F7dEV-VHLnGbYE#2KAN(h34G=hXQNQZQHNeCh>-2#e~D12w| z@qM57dFK1&`mX=t+MF|U&e?nIwb$PJUTfWF=#<4JSvXiZ(dmlkKt&Dc93Xa(qlpc= zfB=Y1-P_3=#3p9!W^CtZ31U+=wlsGIfq@%TK|(_4<_>1C8+rcrfTW{?8whfB1Dm#z 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z{BhoIltL_&#Hw=X2ZZmsf^mW?tR*BtEz9l2sPP8v{P_nIK~X#Uz$|s#2xDV583+;m zs40fVuf5YMT^^r;8oYU{w$nQU5w%9Nfn=#l*vCbxvawK}J?&KkyhPp)_OxQD?}D3t zvhhli7c2bpru3muuGRfWqR5}WyrlA#L$bxy2@PYL|_pZLi4ZYz=5oP{yS+D zrby9D-DPn<($?{E%FI3f1j&(y?^9@zO=#m!*K{w&gqK~7fC)JsgZj7Qh;Dicjz+vv zS)<4ENq*7i{3Sp&YbHKd2zC8XIbif;}>U%dFGpzp%l$qCJj;oxPysOX9d`ls+J)89>=G$Eubd~Uu+T! zcW>M*^K<)1E-!_Aq>JTo9fU zy&n3q(Z;{$+|B6p^E>l5#2Lq&4E{yljtjYFoH0c@Eh{&-Ik zumO2%Xqz;DPJb11fwiODya0K=FDKCq)Xz>1zOglHDNlA!;WUpay~k zb9G~we4Srne$R*u08puZD}Rwow}Kd9ZVv=6|Al8|`-(Q!_|3`)}=*KBO`#~r6j%TN literal 0 HcmV?d00001 diff --git a/benchmarking/cci_2026_atera/topolink_cci_classic_axes/reports/topolink_cci_classic_axes_candidates.md b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/reports/topolink_cci_classic_axes_candidates.md new file mode 100644 index 0000000..b1d0390 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/reports/topolink_cci_classic_axes_candidates.md @@ -0,0 +1,103 @@ +# pyXenium high-scoring classic LR candidates + +Input table: `D:\GitHub\pyXenium\benchmarking\cci_2026_atera\pdc_collected\pdc_20260426_1327\runs\full_common\pyxenium\pyxenium_scores.tsv` +Rows scanned: `1,319,600` + +Selection strategy: candidates are sorted by `CCI_score` and filtered to predefined cell-cell interaction pairs with established or strongly interpretable biology. The score is not changed; biological interpretability is an annotation layer. + +## Headline candidates + +| Rank | CCI pair | Sender -> Receiver | CCI_score | Category | Interpretation | +|---:|---|---|---:|---|---| +| 1 | `VWF-SELP` | Endothelial Cells -> Endothelial Cells | 0.791 | WPB / endothelial activation | Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. | +| 2 | `VWF-LRP1` | Endothelial Cells -> CAFs, DCIS Associated | 0.748 | vascular-stromal matrix/scavenger axis | Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. | +| 3 | `EFNB2-PECAM1` | Endothelial Cells -> Endothelial Cells | 0.747 | endothelial identity / vascular adhesion | Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. | +| 4 | `MMRN2-CLEC14A` | Endothelial Cells -> Endothelial Cells | 0.732 | tumor endothelial angiogenic complex | MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. | +| 5 | `HSPG2-LRP1` | Endothelial Cells -> CAFs, DCIS Associated | 0.728 | basement membrane / ECM receptor | Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. | +| 6 | `COL4A2-CD93` | Endothelial Cells -> Endothelial Cells | 0.712 | basement membrane angiogenesis | COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. | +| 7 | `MMRN2-CD93` | Endothelial Cells -> Endothelial Cells | 0.711 | CD93-MMRN2 angiogenesis | MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. | +| 8 | `VWF-ITGA9` | Endothelial Cells -> Endothelial Cells | 0.708 | vascular adhesion / integrin | VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. | +| 9 | `MMP2-PECAM1` | CAFs, DCIS Associated -> Endothelial Cells | 0.697 | CAF-endothelial remodeling | CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. | +| 10 | `CD48-CD2` | T Lymphocytes -> T Lymphocytes | 0.685 | T-cell adhesion/co-stimulation | T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. | +| 11 | `VEGFC-FLT1` | Endothelial Cells -> Endothelial Cells | 0.684 | VEGF/angiogenesis | VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. | +| 12 | `DLL4-NOTCH3` | Endothelial Cells -> Pericytes | 0.670 | endothelial-pericyte Notch | Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. | +| 13 | `CXCL12-CXCR4` | CAFs, DCIS Associated -> T Lymphocytes | 0.662 | canonical CAF-immune chemokine axis | CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. | +| 14 | `THBS2-CD36` | CAFs, DCIS Associated -> Endothelial Cells | 0.653 | stromal matrix angiogenesis | CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. | +| 15 | `JAG1-NOTCH2` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.634 | tumor Notch signaling | Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. | + +## Biology groups + +### vascular WPB +- `VWF-SELP` (Endothelial Cells -> Endothelial Cells, CCI_score=0.791): VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. +- `VWF-ITGA9` (Endothelial Cells -> Endothelial Cells, CCI_score=0.708): Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. + +### vascular identity +- `EFNB2-PECAM1` (Endothelial Cells -> Endothelial Cells, CCI_score=0.747): Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. + +### vascular stromal ECM +- `VWF-LRP1` (Endothelial Cells -> CAFs, DCIS Associated, CCI_score=0.748): This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. +- `HSPG2-LRP1` (Endothelial Cells -> CAFs, DCIS Associated, CCI_score=0.728): LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. + +### angiogenesis matrix +- `MMRN2-CLEC14A` (Endothelial Cells -> Endothelial Cells, CCI_score=0.732): CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. +- `COL4A2-CD93` (Endothelial Cells -> Endothelial Cells, CCI_score=0.712): CD93 is implicated in endothelial matrix organization and tumor angiogenesis. +- `MMRN2-CD93` (Endothelial Cells -> Endothelial Cells, CCI_score=0.711): CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. + +### angiogenesis growth factor +- `VEGFC-FLT1` (Endothelial Cells -> Endothelial Cells, CCI_score=0.684): Canonical VEGF-family CCI biology makes this a straightforward angiogenic axis. + +### CAF ECM remodeling +- `MMP2-PECAM1` (CAFs, DCIS Associated -> Endothelial Cells, CCI_score=0.697): MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. +- `THBS2-CD36` (CAFs, DCIS Associated -> Endothelial Cells, CCI_score=0.653): THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. + +### Notch pericyte +- `DLL4-NOTCH3` (Endothelial Cells -> Pericytes, CCI_score=0.670): Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. + +### tumor Notch +- `JAG1-NOTCH2` (11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells, CCI_score=0.634): JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. + +### immune recruitment +- `CXCL12-CXCR4` (CAFs, DCIS Associated -> T Lymphocytes, CCI_score=0.662): CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. + +### T cell signaling +- `CD48-CD2` (T Lymphocytes -> T Lymphocytes, CCI_score=0.685): CD48-CD2 has experimental support in T-cell adhesion and activation contexts. + +## High-score non-classic caveats + +These rows scored highly but were not used as headline classic LR discoveries because their interpretation is less clean as an extracellular cell-cell interaction axis. + +| Global rank | CCI pair | Sender -> Receiver | CCI_score | Reason | +|---:|---|---|---:|---| +| 4 | `GNAS-ADCY1` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.742 | High score but more intracellular second-messenger pathway than interpretable extracellular LR. | +| 5 | `CDH1-IGF1R` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.741 | Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline. | +| 8 | `CDH1-PTPRF` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.713 | Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery. | +| 12 | `DSC3-DSG3` | Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells | 0.705 | Desmosomal adhesion within DCIS; important structure biology but not a classic cell-cell interaction signaling axis. | +| 22 | `DSG1-DSC3` | Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells | 0.673 | Desmosomal adhesion within DCIS; important structure biology but not a classic cell-cell interaction signaling axis. | +| 23 | `JAG1-CD46` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.672 | Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH. | +| 31 | `PSAP-CELSR1` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.653 | Potentially interpretable but not prioritized as a classic cancer LR axis here. | +| 34 | `APP-LRP10` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.645 | High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. | +| 35 | `ADAM10-NOTCH2` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.643 | Notch proteolysis context rather than a cell-cell interaction pair; kept as caveat not headline. | +| 36 | `ADAM15-ITGB1` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.643 | Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. | +| 43 | `SPTAN1-PTPRA` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells | 0.635 | Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline. | +| 44 | `TNC-SDC4` | Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells | 0.634 | ECM-syndecan axis is plausible but not in the preregistered classic headline set. | +| 232 | `APP-LRP10` | Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells | 0.544 | High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. | +| 274 | `TNC-SDC4` | Myoepithelial Cells -> 11q13 Invasive Tumor Cells | 0.532 | ECM-syndecan axis is plausible but not in the preregistered classic headline set. | +| 517 | `GNAS-ADCY1` | 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) | 0.489 | High score but more intracellular second-messenger pathway than interpretable extracellular LR. | + +## References + +- Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ +- Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. +- Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 +- CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ +- Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ +- Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ +- Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ +- The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ + +## Output files + +- `tables/topolink_cci_classic_axes_candidates.tsv`: headline representatives. +- `tables/topolink_cci_classic_axes_candidates_all.tsv`: all matching classic LR rows across sender-receiver contexts. +- `tables/pyxenium_high_score_nonclassic_caveats.tsv`: high-scoring rows deliberately not used as headline classic LR discoveries. +- `figures/topolink_cci_classic_axes_top_axes.png`: compact ranked figure. diff --git a/benchmarking/cci_2026_atera/topolink_cci_classic_axes/select_topolink_cci_classic_axes_candidates.py b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/select_topolink_cci_classic_axes_candidates.py new file mode 100644 index 0000000..3ef6606 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/select_topolink_cci_classic_axes_candidates.py @@ -0,0 +1,572 @@ +"""Select high-scoring, biologically interpretable classic LR axes. + +This script scans the full pyXenium whole-dataset LR score table and creates +curated outputs for manuscript-style interpretation. It uses CCI_score as the +primary ranking signal and applies a predefined classic-biology annotation +layer rather than learning or changing scores. +""" + +from __future__ import annotations + +import json +from dataclasses import dataclass +from pathlib import Path + +import matplotlib.pyplot as plt +import pandas as pd + + +ROOT = Path(__file__).resolve().parent +BENCHMARK_ROOT = ROOT.parent +INPUT = ( + BENCHMARK_ROOT + / "pdc_collected" + / "pdc_20260426_1327" + / "runs" + / "full_common" + / "pyxenium" + / "pyxenium_scores.tsv" +) +TABLES = ROOT / "tables" +FIGURES = ROOT / "figures" +REPORTS = ROOT / "reports" + +USECOLS = [ + "ligand", + "receptor", + "sender_celltype", + "receiver_celltype", + "sender_anchor", + "receiver_anchor", + "structure_bridge", + "sender_expr", + "receiver_expr", + "local_contact", + "contact_strength_raw", + "contact_strength_normalized", + "contact_coverage", + "cross_edge_count", + "prior_confidence", + "CCI_score", +] + + +@dataclass(frozen=True) +class PairAnnotation: + category: str + biology_label: str + interpretation: str + evidence_note: str + reference_key: str + headline: bool = False + + +REFERENCES = { + "wpb": "Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/", + "cd93_mmrn2": "CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/", + "notch_pericyte": "Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/", + "cxcl12": "Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/", + "cd48_cd2": "Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/", + "jag1_notch": "The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/", + "ecm_lrp1": "Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis.", + "vegf": "Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097", + "immune_checkpoint": "KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis.", +} + + +PAIR_ANNOTATIONS: dict[tuple[str, str], PairAnnotation] = { + ("VWF", "SELP"): PairAnnotation( + "vascular_WPB", + "WPB / endothelial activation", + "Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state.", + "VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling.", + "wpb", + True, + ), + ("VWF", "LRP1"): PairAnnotation( + "vascular_stromal_ECM", + "vascular-stromal matrix/scavenger axis", + "Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface.", + "This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim.", + "ecm_lrp1", + True, + ), + ("EFNB2", "PECAM1"): PairAnnotation( + "vascular_identity", + "endothelial identity / vascular adhesion", + "Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis.", + "Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling.", + "vegf", + True, + ), + ("MMRN2", "CLEC14A"): PairAnnotation( + "angiogenesis_matrix", + "tumor endothelial angiogenic complex", + "MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state.", + "CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs.", + "cd93_mmrn2", + True, + ), + ("HSPG2", "LRP1"): PairAnnotation( + "vascular_stromal_ECM", + "basement membrane / ECM receptor", + "Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling.", + "LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context.", + "ecm_lrp1", + True, + ), + ("COL4A2", "CD93"): PairAnnotation( + "angiogenesis_matrix", + "basement membrane angiogenesis", + "COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state.", + "CD93 is implicated in endothelial matrix organization and tumor angiogenesis.", + "cd93_mmrn2", + True, + ), + ("MMRN2", "CD93"): PairAnnotation( + "angiogenesis_matrix", + "CD93-MMRN2 angiogenesis", + "MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis.", + "CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis.", + "cd93_mmrn2", + True, + ), + ("VWF", "ITGA9"): PairAnnotation( + "vascular_WPB", + "vascular adhesion / integrin", + "VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods.", + "Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact.", + "wpb", + True, + ), + ("MMP2", "PECAM1"): PairAnnotation( + "CAF_ECM_remodeling", + "CAF-endothelial remodeling", + "CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature.", + "MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial.", + "ecm_lrp1", + True, + ), + ("COL4A1", "CD93"): PairAnnotation( + "angiogenesis_matrix", + "basement membrane angiogenesis", + "COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis.", + "Kept in appendix/main table but treated as partially redundant with COL4A2-CD93.", + "cd93_mmrn2", + ), + ("CXCL12", "CXCR4"): PairAnnotation( + "immune_recruitment", + "canonical CAF-immune chemokine axis", + "CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis.", + "CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance.", + "cxcl12", + True, + ), + ("CXCL12", "ITGA4"): PairAnnotation( + "immune_recruitment", + "CAF-T cell immune recruitment/adhesion", + "CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment.", + "Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4.", + "cxcl12", + ), + ("CD48", "CD2"): PairAnnotation( + "T_cell_signaling", + "T-cell adhesion/co-stimulation", + "T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology.", + "CD48-CD2 has experimental support in T-cell adhesion and activation contexts.", + "cd48_cd2", + True, + ), + ("CLEC2D", "KLRB1"): PairAnnotation( + "T_cell_signaling", + "T/NK immune-regulatory interaction", + "CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood.", + "Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4.", + "immune_checkpoint", + ), + ("CD34", "SELP"): PairAnnotation( + "vascular_WPB", + "endothelial adhesion", + "CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit.", + "SELP/P-selectin biology links this to endothelial activation and adhesion.", + "wpb", + True, + ), + ("VEGFC", "FLT1"): PairAnnotation( + "angiogenesis_growth_factor", + "VEGF/angiogenesis", + "VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation.", + "Canonical VEGF-family CCI biology makes this a straightforward angiogenic axis.", + "vegf", + True, + ), + ("DLL4", "NOTCH3"): PairAnnotation( + "Notch_pericyte", + "endothelial-pericyte Notch", + "Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology.", + "Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts.", + "notch_pericyte", + True, + ), + ("DLL4", "NOTCH4"): PairAnnotation( + "Notch_vascular", + "endothelial Notch/angiogenesis", + "DLL4-NOTCH4 extends the endothelial Notch angiogenesis module.", + "Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3.", + "notch_pericyte", + ), + ("DLL1", "NOTCH3"): PairAnnotation( + "Notch_pericyte", + "endothelial-pericyte Notch", + "DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis.", + "Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3.", + "notch_pericyte", + ), + ("JAG1", "NOTCH2"): PairAnnotation( + "tumor_Notch", + "tumor Notch signaling", + "Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells.", + "JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance.", + "jag1_notch", + True, + ), + ("C3", "LRP1"): PairAnnotation( + "complement_scavenger", + "complement-ECM/scavenger receptor", + "C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods.", + "Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks.", + "ecm_lrp1", + ), + ("A2M", "LRP1"): PairAnnotation( + "complement_scavenger", + "protease inhibitor/scavenger receptor", + "A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches.", + "LRP1 is a plausible receptor for protease-inhibitor/scavenger biology.", + "ecm_lrp1", + ), + ("C1QB", "LRP1"): PairAnnotation( + "complement_scavenger", + "macrophage-CAF complement/scavenger axis", + "Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches.", + "Useful as a myeloid-stromal hypothesis rather than a vascular headline axis.", + "ecm_lrp1", + ), + ("THBS2", "CD36"): PairAnnotation( + "CAF_ECM_remodeling", + "stromal matrix angiogenesis", + "CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology.", + "THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context.", + "ecm_lrp1", + True, + ), + ("CCN1", "CAV1"): PairAnnotation( + "CAF_ECM_remodeling", + "mechanovascular signaling", + "CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis.", + "Treat as a topology-supported mechanovascular hypothesis.", + "ecm_lrp1", + ), +} + +HEADLINE_KEYS = [ + ("VWF", "SELP"), + ("VWF", "LRP1"), + ("EFNB2", "PECAM1"), + ("MMRN2", "CLEC14A"), + ("HSPG2", "LRP1"), + ("COL4A2", "CD93"), + ("MMRN2", "CD93"), + ("VWF", "ITGA9"), + ("MMP2", "PECAM1"), + ("CXCL12", "CXCR4"), + ("DLL4", "NOTCH3"), + ("CD48", "CD2"), + ("VEGFC", "FLT1"), + ("THBS2", "CD36"), + ("JAG1", "NOTCH2"), +] + +NONCLASSIC_CAVEATS = { + ("GNAS", "ADCY1"): "High score but more intracellular second-messenger pathway than interpretable extracellular LR.", + ("CDH1", "IGF1R"): "Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline.", + ("CDH1", "PTPRF"): "Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery.", + ("DSC3", "DSG3"): "Desmosomal adhesion within DCIS; important structure biology but not a classic cell-cell interaction signaling axis.", + ("DSG1", "DSC3"): "Desmosomal adhesion within DCIS; important structure biology but not a classic cell-cell interaction signaling axis.", + ("JAG1", "CD46"): "Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH.", + ("PSAP", "CELSR1"): "Potentially interpretable but not prioritized as a classic cancer LR axis here.", + ("APP", "LRP10"): "High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report.", + ("ADAM10", "NOTCH2"): "Notch proteolysis context rather than a cell-cell interaction pair; kept as caveat not headline.", + ("ADAM15", "ITGB1"): "Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes.", + ("SPTAN1", "PTPRA"): "Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline.", + ("TNC", "SDC4"): "ECM-syndecan axis is plausible but not in the preregistered classic headline set.", +} + +CATEGORY_ORDER = [ + "vascular_WPB", + "vascular_identity", + "vascular_stromal_ECM", + "angiogenesis_matrix", + "angiogenesis_growth_factor", + "CAF_ECM_remodeling", + "Notch_pericyte", + "tumor_Notch", + "immune_recruitment", + "T_cell_signaling", + "complement_scavenger", +] + +CATEGORY_COLORS = { + "vascular_WPB": "#B21E48", + "vascular_identity": "#0F7C80", + "vascular_stromal_ECM": "#6A994E", + "angiogenesis_matrix": "#2A9D8F", + "angiogenesis_growth_factor": "#3A86FF", + "CAF_ECM_remodeling": "#B08968", + "Notch_pericyte": "#7B2CBF", + "tumor_Notch": "#D00000", + "immune_recruitment": "#2E8B57", + "T_cell_signaling": "#F4A261", + "complement_scavenger": "#5C677D", +} + + +def annotate_row(row: pd.Series, global_rank: int) -> dict[str, object]: + key = (row["ligand"], row["receptor"]) + ann = PAIR_ANNOTATIONS[key] + return { + "global_rank": global_rank, + "ligand": row["ligand"], + "receptor": row["receptor"], + "lr_pair": f"{row['ligand']}-{row['receptor']}", + "sender": row["sender_celltype"], + "receiver": row["receiver_celltype"], + "sender_receiver": f"{row['sender_celltype']} -> {row['receiver_celltype']}", + "CCI_score": row["CCI_score"], + "sender_anchor": row["sender_anchor"], + "receiver_anchor": row["receiver_anchor"], + "structure_bridge": row["structure_bridge"], + "sender_expr": row["sender_expr"], + "receiver_expr": row["receiver_expr"], + "local_contact": row["local_contact"], + "contact_strength_raw": row["contact_strength_raw"], + "contact_strength_normalized": row["contact_strength_normalized"], + "contact_coverage": row["contact_coverage"], + "cross_edge_count": row["cross_edge_count"], + "prior_confidence": row["prior_confidence"], + "category": ann.category, + "biology_label": ann.biology_label, + "interpretation": ann.interpretation, + "evidence_note": ann.evidence_note, + "reference_key": ann.reference_key, + "reference": REFERENCES[ann.reference_key], + "headline_predefined": key in HEADLINE_KEYS, + } + + +def scan_scores() -> tuple[pd.DataFrame, pd.DataFrame, int]: + allowed_keys = set(PAIR_ANNOTATIONS) + caveat_keys = set(NONCLASSIC_CAVEATS) + selected: list[dict[str, object]] = [] + caveats: list[dict[str, object]] = [] + row_offset = 0 + + for chunk in pd.read_csv(INPUT, sep="\t", usecols=USECOLS, chunksize=200_000): + for idx, row in chunk.iterrows(): + global_rank = row_offset + (idx - chunk.index[0]) + 1 + key = (row["ligand"], row["receptor"]) + if key in allowed_keys: + selected.append(annotate_row(row, global_rank)) + elif key in caveat_keys and len(caveats) < 80: + caveats.append( + { + "global_rank": global_rank, + "ligand": row["ligand"], + "receptor": row["receptor"], + "lr_pair": f"{row['ligand']}-{row['receptor']}", + "sender": row["sender_celltype"], + "receiver": row["receiver_celltype"], + "CCI_score": row["CCI_score"], + "local_contact": row["local_contact"], + "cross_edge_count": row["cross_edge_count"], + "reason_not_headline": NONCLASSIC_CAVEATS[key], + } + ) + row_offset += len(chunk) + + selected_df = pd.DataFrame(selected).sort_values(["CCI_score", "global_rank"], ascending=[False, True]) + caveat_df = pd.DataFrame(caveats).sort_values(["CCI_score", "global_rank"], ascending=[False, True]) + return selected_df, caveat_df, row_offset + + +def choose_headline(selected_df: pd.DataFrame) -> pd.DataFrame: + rows = [] + for key in HEADLINE_KEYS: + lig, rec = key + sub = selected_df[(selected_df["ligand"] == lig) & (selected_df["receptor"] == rec)] + if sub.empty: + raise RuntimeError(f"Missing headline CCI pair {lig}-{rec}") + rows.append(sub.sort_values(["CCI_score", "global_rank"], ascending=[False, True]).iloc[0]) + headline = pd.DataFrame(rows).sort_values(["CCI_score", "global_rank"], ascending=[False, True]).reset_index(drop=True) + headline.insert(0, "classic_cci_rank", range(1, len(headline) + 1)) + return headline + + +def write_tables(headline: pd.DataFrame, selected_df: pd.DataFrame, caveat_df: pd.DataFrame, n_rows: int) -> None: + TABLES.mkdir(parents=True, exist_ok=True) + headline.to_csv(TABLES / "topolink_cci_classic_axes_candidates.tsv", sep="\t", index=False) + selected_df.to_csv(TABLES / "topolink_cci_classic_axes_candidates_all.tsv", sep="\t", index=False) + caveat_df.to_csv(TABLES / "pyxenium_high_score_nonclassic_caveats.tsv", sep="\t", index=False) + summary = { + "input": str(INPUT), + "input_rows": n_rows, + "headline_rows": int(len(headline)), + "all_classic_rows": int(len(selected_df)), + "caveat_rows": int(len(caveat_df)), + "headline_top": headline[["lr_pair", "sender_receiver", "CCI_score"]].head(5).to_dict(orient="records"), + } + (TABLES / "topolink_cci_classic_axes_summary.json").write_text(json.dumps(summary, indent=2), encoding="utf-8") + + +def make_figure(headline: pd.DataFrame) -> None: + FIGURES.mkdir(parents=True, exist_ok=True) + df = headline.sort_values("CCI_score", ascending=True) + labels = [f"{r.lr_pair}\n{r.sender} -> {r.receiver}" for r in df.itertuples()] + colors = [CATEGORY_COLORS.get(c, "#7E7E7E") for c in df["category"]] + + plt.rcParams.update({"font.family": "DejaVu Sans"}) + fig, ax = plt.subplots(figsize=(12, 8.5), dpi=220) + ax.barh(range(len(df)), df["CCI_score"], color=colors, alpha=0.92) + ax.set_yticks(range(len(df))) + ax.set_yticklabels(labels, fontsize=8) + ax.set_xlabel("pyXenium CCI_score", fontsize=11) + ax.set_title("High-scoring classic TopoLink-CCI axes with strong biological interpretability", fontsize=13, weight="bold") + ax.grid(axis="x", color="#E5E7EB", linewidth=0.9) + ax.set_axisbelow(True) + for i, score in enumerate(df["CCI_score"]): + ax.text(score + 0.006, i, f"{score:.3f}", va="center", fontsize=8) + for spine in ["top", "right", "left"]: + ax.spines[spine].set_visible(False) + ax.set_xlim(0, max(0.84, df["CCI_score"].max() + 0.05)) + + handles = [] + seen = [] + for category in headline["category"]: + if category not in seen: + seen.append(category) + handles.append(plt.Line2D([0], [0], marker="s", linestyle="", color=CATEGORY_COLORS[category], label=category.replace("_", " "))) + ax.legend(handles=handles, loc="lower right", fontsize=7, frameon=False) + fig.tight_layout() + fig.savefig(FIGURES / "topolink_cci_classic_axes_top_axes.png", bbox_inches="tight") + fig.savefig(FIGURES / "topolink_cci_classic_axes_top_axes.pdf", bbox_inches="tight") + plt.close(fig) + + +def write_report(headline: pd.DataFrame, selected_df: pd.DataFrame, caveat_df: pd.DataFrame, n_rows: int) -> None: + REPORTS.mkdir(parents=True, exist_ok=True) + lines: list[str] = [] + lines.append("# pyXenium high-scoring classic LR candidates") + lines.append("") + lines.append(f"Input table: `{INPUT}`") + lines.append(f"Rows scanned: `{n_rows:,}`") + lines.append("") + lines.append( + "Selection strategy: candidates are sorted by `CCI_score` and filtered to predefined cell-cell interaction pairs with established or strongly interpretable biology. The score is not changed; biological interpretability is an annotation layer." + ) + lines.append("") + lines.append("## Headline candidates") + lines.append("") + lines.append("| Rank | CCI pair | Sender -> Receiver | CCI_score | Category | Interpretation |") + lines.append("|---:|---|---|---:|---|---|") + for row in headline.itertuples(index=False): + lines.append( + f"| {row.classic_cci_rank} | `{row.lr_pair}` | {row.sender_receiver} | {row.CCI_score:.3f} | {row.biology_label} | {row.interpretation} |" + ) + + lines.append("") + lines.append("## Biology groups") + for category in CATEGORY_ORDER: + sub = headline[headline["category"] == category] + if sub.empty: + continue + lines.append("") + lines.append(f"### {category.replace('_', ' ')}") + for row in sub.itertuples(index=False): + lines.append( + f"- `{row.lr_pair}` ({row.sender_receiver}, CCI_score={row.CCI_score:.3f}): {row.evidence_note}" + ) + + lines.append("") + lines.append("## High-score non-classic caveats") + lines.append("") + lines.append("These rows scored highly but were not used as headline classic LR discoveries because their interpretation is less clean as an extracellular cell-cell interaction axis.") + lines.append("") + lines.append("| Global rank | CCI pair | Sender -> Receiver | CCI_score | Reason |") + lines.append("|---:|---|---|---:|---|") + for row in caveat_df.head(15).itertuples(index=False): + lines.append( + f"| {row.global_rank} | `{row.lr_pair}` | {row.sender} -> {row.receiver} | {row.CCI_score:.3f} | {row.reason_not_headline} |" + ) + + lines.append("") + lines.append("## References") + lines.append("") + used_keys = list(dict.fromkeys(headline["reference_key"].tolist())) + for key in used_keys: + lines.append(f"- {REFERENCES[key]}") + lines.append("") + lines.append("## Output files") + lines.append("") + lines.append("- `tables/topolink_cci_classic_axes_candidates.tsv`: headline representatives.") + lines.append("- `tables/topolink_cci_classic_axes_candidates_all.tsv`: all matching classic LR rows across sender-receiver contexts.") + lines.append("- `tables/pyxenium_high_score_nonclassic_caveats.tsv`: high-scoring rows deliberately not used as headline classic LR discoveries.") + lines.append("- `figures/topolink_cci_classic_axes_top_axes.png`: compact ranked figure.") + + (REPORTS / "topolink_cci_classic_axes_candidates.md").write_text("\n".join(lines) + "\n", encoding="utf-8") + + +def validate(headline: pd.DataFrame, selected_df: pd.DataFrame, caveat_df: pd.DataFrame, n_rows: int) -> None: + if n_rows != 1_319_600: + raise RuntimeError(f"Expected 1,319,600 rows, found {n_rows:,}") + if headline["CCI_score"].is_monotonic_decreasing is False: + raise RuntimeError("Headline candidates are not sorted by CCI_score descending.") + required = { + "classic_cci_rank", + "global_rank", + "lr_pair", + "sender_receiver", + "CCI_score", + "sender_anchor", + "receiver_anchor", + "structure_bridge", + "sender_expr", + "receiver_expr", + "local_contact", + "cross_edge_count", + "biology_label", + "interpretation", + } + missing = required.difference(headline.columns) + if missing: + raise RuntimeError(f"Missing required headline columns: {sorted(missing)}") + if headline["biology_label"].isna().any() or headline["interpretation"].isna().any(): + raise RuntimeError("Every headline candidate must have biology label and interpretation.") + if selected_df.empty: + raise RuntimeError("No classic LR rows found.") + if caveat_df.empty: + raise RuntimeError("No caveat rows found; expected at least GNAS-ADCY1/CDH1-related caveats.") + + +def main() -> None: + selected_df, caveat_df, n_rows = scan_scores() + headline = choose_headline(selected_df) + validate(headline, selected_df, caveat_df, n_rows) + write_tables(headline, selected_df, caveat_df, n_rows) + make_figure(headline) + write_report(headline, selected_df, caveat_df, n_rows) + print(f"Scanned {n_rows:,} rows") + print(f"Wrote {len(headline)} headline candidates and {len(selected_df):,} all classic rows") + print(f"Top candidate: {headline.iloc[0]['lr_pair']} ({headline.iloc[0]['CCI_score']:.6f})") + + +if __name__ == "__main__": + main() diff --git a/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/pyxenium_high_score_nonclassic_caveats.tsv b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/pyxenium_high_score_nonclassic_caveats.tsv new file mode 100644 index 0000000..62d31f6 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/pyxenium_high_score_nonclassic_caveats.tsv @@ -0,0 +1,81 @@ +global_rank ligand receptor lr_pair sender receiver CCI_score local_contact cross_edge_count reason_not_headline +4 GNAS ADCY1 GNAS-ADCY1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.7422577389472655 0.2255335728070659 423716 High score but more intracellular second-messenger pathway than interpretable extracellular LR. +5 CDH1 IGF1R CDH1-IGF1R 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.7406542390481928 0.2223361518692711 423716 Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline. +8 CDH1 PTPRF CDH1-PTPRF 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.712640611425387 0.2113863855814468 423716 Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery. +12 DSC3 DSG3 DSC3-DSG3 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells 0.7051220145590659 0.1363605403915987 19576 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +22 DSG1 DSC3 DSG1-DSC3 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells 0.6733599636451991 0.1069700086678183 19576 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +23 JAG1 CD46 JAG1-CD46 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6724442612707839 0.1452740875425554 423716 Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH. +31 PSAP CELSR1 PSAP-CELSR1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6534893280773154 0.1238269455876684 423716 Potentially interpretable but not prioritized as a classic cancer LR axis here. +34 APP LRP10 APP-LRP10 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6450511179922087 0.1364197730296376 423716 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. +35 ADAM10 NOTCH2 ADAM10-NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6434655313039473 0.1329119697153242 423716 Notch proteolysis context rather than a ligand-receptor pair; kept as caveat not headline. +36 ADAM15 ITGB1 ADAM15-ITGB1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6434150737795984 0.1176201348184846 423716 Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. +43 SPTAN1 PTPRA SPTAN1-PTPRA 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6347189866848398 0.1242211614128196 423716 Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline. +44 TNC SDC4 TNC-SDC4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.6339533570532268 0.1216103641854385 30217 ECM-syndecan axis is plausible but not in the preregistered classic headline set. +232 APP LRP10 APP-LRP10 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.5441244342376652 0.1957620964965583 30217 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. +274 TNC SDC4 TNC-SDC4 Myoepithelial Cells 11q13 Invasive Tumor Cells 0.5321950717183764 0.0727133914731768 5095 ECM-syndecan axis is plausible but not in the preregistered classic headline set. +517 GNAS ADCY1 GNAS-ADCY1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.4888840107365182 0.3167051694238438 11947 High score but more intracellular second-messenger pathway than interpretable extracellular LR. +544 CDH1 PTPRF CDH1-PTPRF 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.4845768405501682 0.1610989999870924 30400 Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery. +550 DSC3 DSG3 DSC3-DSG3 Myoepithelial Cells Basal-like Structured DCIS Cells 0.4834051558214019 0.0602290574073945 6875 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +557 DSC3 DSG3 DSC3-DSG3 Myoepithelial Cells Myoepithelial Cells 0.4819320263007474 0.0854785554948862 22361 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +594 DSC3 DSG3 DSC3-DSG3 Basal-like Structured DCIS Cells Myoepithelial Cells 0.4771686589417661 0.0492725553705028 6412 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +615 GNAS ADCY1 GNAS-ADCY1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.4749726727435887 0.3035098377626061 12090 High score but more intracellular second-messenger pathway than interpretable extracellular LR. +678 GNAS ADCY1 GNAS-ADCY1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.4675156087292866 0.2933613051324652 12101 High score but more intracellular second-messenger pathway than interpretable extracellular LR. +686 CDH1 IGF1R CDH1-IGF1R 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.4662454985533772 0.248644026731182 11947 Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline. +747 DSC3 DSG3 DSC3-DSG3 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.4600140556761605 0.0385980386451065 30217 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +875 SPTAN1 PTPRA SPTAN1-PTPRA 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.4466922427830364 0.115856563519626 30400 Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline. +878 ADAM15 ITGB1 ADAM15-ITGB1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.4464820333840988 0.0929499973921891 30400 Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. +980 GNAS ADCY1 GNAS-ADCY1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.437803165275602 0.1199047061548118 30217 High score but more intracellular second-messenger pathway than interpretable extracellular LR. +1042 SPTAN1 PTPRA SPTAN1-PTPRA 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.4333760670290844 0.1577705665157472 11947 Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline. +1107 CDH1 IGF1R CDH1-IGF1R 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.4289746881872208 0.2439407306688381 12101 Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline. +1131 PSAP CELSR1 PSAP-CELSR1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.4274432207881662 0.1531720578949295 11947 Potentially interpretable but not prioritized as a classic cancer LR axis here. +1142 TNC SDC4 TNC-SDC4 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells 0.4270350112478229 0.129046675836071 19576 ECM-syndecan axis is plausible but not in the preregistered classic headline set. +1161 PSAP CELSR1 PSAP-CELSR1 Dendritic Cells 11q13 Invasive Tumor Cells 0.4261304411040353 0.0798780350772116 3945 Potentially interpretable but not prioritized as a classic cancer LR axis here. +1267 CDH1 IGF1R CDH1-IGF1R 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.4194102372215892 0.2310630839178011 12090 Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline. +1282 DSG1 DSC3 DSG1-DSC3 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.4186003250600476 0.0309794231435145 30217 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +1332 ADAM15 ITGB1 ADAM15-ITGB1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.4155210769969529 0.1545014913528931 12101 Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. +1358 JAG1 CD46 JAG1-CD46 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.4144093982900916 0.1713405392232128 12101 Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH. +1458 DSG1 DSC3 DSG1-DSC3 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.4097300198392939 0.0178252618357987 30400 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +1723 GNAS ADCY1 GNAS-ADCY1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.3981188005538885 0.2047800801964718 12020 High score but more intracellular second-messenger pathway than interpretable extracellular LR. +1752 CDH1 PTPRF CDH1-PTPRF 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.3968774837783868 0.1833030422330573 12101 Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery. +1755 CDH1 PTPRF CDH1-PTPRF 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.3968075132310019 0.1768403117480427 11947 Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery. +1812 DSC3 DSG3 DSC3-DSG3 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.3946749572523563 0.021039629655145 30400 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +1834 SPTAN1 PTPRA SPTAN1-PTPRA 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.3939846532572499 0.1417835912252122 12020 Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline. +1891 CDH1 IGF1R CDH1-IGF1R 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.391599375535714 0.1735213317291221 12020 Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline. +1913 CDH1 PTPRF CDH1-PTPRF 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.3905877635866572 0.180611250173479 12090 Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery. +1932 DSG1 DSC3 DSG1-DSC3 Basal-like Structured DCIS Cells Myoepithelial Cells 0.3896053500886826 0.0170750865263605 6412 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +1967 SPTAN1 PTPRA SPTAN1-PTPRA 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.3883224355556799 0.1586559836129202 12101 Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline. +2084 ADAM15 ITGB1 ADAM15-ITGB1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.3833557897562838 0.11813633920097 11947 Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. +2152 JAG1 CD46 JAG1-CD46 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.3813854547247657 0.1206835759168673 11947 Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH. +2224 ADAM10 NOTCH2 ADAM10-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.378344766919634 0.1135648349102913 12101 Notch proteolysis context rather than a ligand-receptor pair; kept as caveat not headline. +2420 JAG1 CD46 JAG1-CD46 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.3717420533973906 0.0747024377379979 30400 Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH. +2442 CDH1 PTPRF CDH1-PTPRF 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.3712271089301701 0.1588331775390813 12020 Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery. +2574 ADAM10 NOTCH2 ADAM10-NOTCH2 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.3671797284626545 0.0712678863676429 30400 Notch proteolysis context rather than a ligand-receptor pair; kept as caveat not headline. +2588 CDH1 IGF1R CDH1-IGF1R 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.3666804273541625 0.0852249665172101 30400 Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline. +2598 ADAM15 ITGB1 ADAM15-ITGB1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.3664385943901078 0.1099846026713969 12020 Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. +2626 APP LRP10 APP-LRP10 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 0.3656681871178363 0.0909467914740884 30400 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. +2752 PSAP CELSR1 PSAP-CELSR1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.3625636247703948 0.0577502347848629 30217 Potentially interpretable but not prioritized as a classic cancer LR axis here. +2842 APP LRP10 APP-LRP10 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.3604116634495393 0.1217384336823036 12090 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. +2878 JAG1 CD46 JAG1-CD46 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.3596640737340433 0.1192864279045575 12090 Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH. +2916 PSAP CELSR1 PSAP-CELSR1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.3587735983566544 0.1193221815824134 12090 Potentially interpretable but not prioritized as a classic cancer LR axis here. +3126 ADAM10 NOTCH2 ADAM10-NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.3540127427795173 0.1119538304848802 11947 Notch proteolysis context rather than a ligand-receptor pair; kept as caveat not headline. +3166 PSAP CELSR1 PSAP-CELSR1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.3530448809099077 0.1095138354033406 12101 Potentially interpretable but not prioritized as a classic cancer LR axis here. +3310 SPTAN1 PTPRA SPTAN1-PTPRA Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.3495694396367951 0.0572671352929593 30217 Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline. +3312 APP LRP10 APP-LRP10 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 0.3495475815495912 0.1027839943800042 12101 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. +3378 ADAM10 NOTCH2 ADAM10-NOTCH2 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.3474759265834617 0.0918089013544491 12090 Notch proteolysis context rather than a ligand-receptor pair; kept as caveat not headline. +3400 JAG1 CD46 JAG1-CD46 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.3470587712651683 0.1048607856597584 12020 Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH. +3484 CDH1 IGF1R CDH1-IGF1R Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.3452605817507778 0.0658041162465769 30217 Interesting tumor epithelial adhesion/growth receptor context, but less clean as a classic LR headline. +3528 ADAM15 ITGB1 ADAM15-ITGB1 11q13 Invasive Tumor Cells Myoepithelial Cells 0.3442116599372503 0.0529182754235811 5163 Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. +3566 SPTAN1 PTPRA SPTAN1-PTPRA 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.3433315685580569 0.1143776862329893 12090 Cytoskeletal/phosphatase context; not treated as a classic extracellular LR headline. +3583 DSC3 DSG3 DSC3-DSG3 Myoepithelial Cells 11q13 Invasive Tumor Cells 0.3430590022337168 0.0223639010209444 5095 Desmosomal adhesion within DCIS; important structure biology but not a classic ligand-receptor signaling axis. +3588 ADAM10 NOTCH2 ADAM10-NOTCH2 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.3430254884836697 0.0557379340403134 30217 Notch proteolysis context rather than a ligand-receptor pair; kept as caveat not headline. +3684 APP LRP10 APP-LRP10 Endothelial Cells 11q13 Invasive Tumor Cells 0.3408453763458665 0.0411318054389772 6003 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. +3757 ADAM15 ITGB1 ADAM15-ITGB1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 0.3394262963444469 0.0357737577288523 4671 Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. +3936 CDH1 PTPRF CDH1-PTPRF Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.3359165684945686 0.0668799937059767 30217 Cell adhesion/phosphatase context; biologically plausible but not a primary classic LR discovery. +3960 ADAM15 ITGB1 ADAM15-ITGB1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 0.3355606349100178 0.0835234644211553 12090 Adhesion/protease-integrin biology; plausible but less classic than selected ECM/vascular axes. +4019 APP LRP10 APP-LRP10 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 0.3345331244772794 0.0931752321142975 11947 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. +4195 PSAP CELSR1 PSAP-CELSR1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.3313413806281707 0.0807206605582701 12020 Potentially interpretable but not prioritized as a classic cancer LR axis here. +4390 APP LRP10 APP-LRP10 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.3278851988520068 0.094846638437458 12020 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. +4496 ADAM10 NOTCH2 ADAM10-NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 0.3258682180324883 0.0956999819732594 12020 Notch proteolysis context rather than a ligand-receptor pair; kept as caveat not headline. +4604 JAG1 CD46 JAG1-CD46 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells 0.3241079917563894 0.0465964724538333 30217 Potential tumor/complement regulatory candidate; lower confidence than canonical JAG1-NOTCH. +4787 TNC SDC4 TNC-SDC4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.3210297065617976 0.0068660045728862 423716 ECM-syndecan axis is plausible but not in the preregistered classic headline set. +4815 APP LRP10 APP-LRP10 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells 0.320700607596048 0.1033263682392766 19576 High-score tumor-intrinsic axis; less directly tied to canonical spatial LR interpretation for this report. diff --git a/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_candidates.tsv b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_candidates.tsv new file mode 100644 index 0000000..565ded9 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_candidates.tsv @@ -0,0 +1,16 @@ +classic_cci_rank global_rank ligand receptor lr_pair sender receiver sender_receiver CCI_score sender_anchor receiver_anchor structure_bridge sender_expr receiver_expr local_contact contact_strength_raw contact_strength_normalized contact_coverage cross_edge_count prior_confidence category biology_label interpretation evidence_note reference_key reference headline_predefined +1 1 VWF SELP VWF-SELP Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7912892368005828 0.955713094717548 0.8819126042133903 1.0 1.0 1.0 0.2912449657481761 0.2087907006523492 1.0 0.1111198059316065 12779 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +2 2 VWF LRP1 VWF-LRP1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.7479758913021439 0.955713094717548 0.7346293219749174 0.7204611100467462 1.0 1.0 0.3461937505325735 0.1519427889568471 1.0 0.1319036006311863 13942 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +3 3 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7469197326713805 0.8640667164982425 0.956444566971872 1.0 1.0 1.0 0.2101050418451564 0.0989465138117223 1.0 0.0578292511151107 12779 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +4 6 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7322091602540813 0.9845127857250529 0.9003264838243337 1.0 1.0 1.0 0.1738559319741048 0.1837519889401885 1.0 0.0395962125361921 12779 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +5 7 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.7279607350660221 0.8818165186409654 0.7346293219749174 0.7204611100467462 1.0 1.0 0.31885311072451 0.1096327643092834 1.0 0.1118921245158513 13942 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +6 9 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7118996799523881 0.8840293712888387 0.8817184225858201 1.0 1.0 1.0 0.1669998679965045 0.1163393066750141 0.9954762497320926 0.0367008373112137 12779 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +7 10 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7107166026857937 0.9845127857250529 0.8817184225858201 1.0 1.0 1.0 0.1484661470807383 0.1953008842632443 1.0 0.0288754988653259 12779 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +8 11 VWF ITGA9 VWF-ITGA9 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7083995070560564 0.955713094717548 0.9404022517663844 1.0 1.0 1.0 0.1406138993850457 0.1048381933427708 1.0 0.0259018702558885 12779 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +9 13 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.6971282135184347 0.718867305289982 0.956444566971872 0.7204611100467462 1.0 1.0 0.2317164323896752 0.110891210066582 1.0 0.0536925050393989 16371 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +10 16 CD48 CD2 CD48-CD2 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.6849877065459009 0.928447473463448 0.8960994285623033 1.0 1.0 1.0 0.1241603897223811 0.0943333961908353 1.0 0.0154158023760135 21212 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +11 18 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.6835286288881741 0.8718210606749883 0.878254460598671 1.0 1.0 1.0 0.1331963977536949 0.0960429871925293 1.0 0.0232412551842867 12779 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +12 24 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.6695148471220083 0.9184503888425788 0.8818326005152037 0.946515890536252 1.0 0.8672894033034337 0.135465098207694 0.1110232299264728 1.0 0.0303190087002372 11379 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +13 28 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.6616803690861207 0.8924110508951895 0.9008184599638702 0.6198216015396206 1.0 1.0 0.1684304172162009 0.1342601297358261 1.0 0.0450706652878317 11604 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +14 32 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.6533579344234645 0.724503440376099 0.8587566561291643 0.7204611100467462 1.0 1.0 0.1735345106193826 0.0716485451917006 1.0 0.0301142263759086 16371 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +15 45 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.6339181063246662 0.7941469661104034 0.663300745568453 1.0 1.0 1.0 0.1231934200799743 0.0525758717990835 0.9012720659704488 0.0168391092146626 423716 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True diff --git a/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_candidates_all.tsv b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_candidates_all.tsv new file mode 100644 index 0000000..d69429a --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_candidates_all.tsv @@ -0,0 +1,10001 @@ +global_rank ligand receptor lr_pair sender receiver sender_receiver CCI_score sender_anchor receiver_anchor structure_bridge sender_expr receiver_expr local_contact contact_strength_raw contact_strength_normalized contact_coverage cross_edge_count prior_confidence category biology_label interpretation evidence_note reference_key reference headline_predefined +1 VWF SELP VWF-SELP Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7912892368005828 0.955713094717548 0.8819126042133903 1.0 1.0 1.0 0.2912449657481761 0.2087907006523492 1.0 0.1111198059316065 12779 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +2 VWF LRP1 VWF-LRP1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.7479758913021439 0.955713094717548 0.7346293219749174 0.7204611100467462 1.0 1.0 0.3461937505325735 0.1519427889568471 1.0 0.1319036006311863 13942 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +3 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7469197326713805 0.8640667164982425 0.956444566971872 1.0 1.0 1.0 0.2101050418451564 0.0989465138117223 1.0 0.0578292511151107 12779 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +6 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7322091602540813 0.9845127857250529 0.9003264838243337 1.0 1.0 1.0 0.1738559319741048 0.1837519889401885 1.0 0.0395962125361921 12779 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +7 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.7279607350660221 0.8818165186409654 0.7346293219749174 0.7204611100467462 1.0 1.0 0.31885311072451 0.1096327643092834 1.0 0.1118921245158513 13942 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +9 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7118996799523881 0.8840293712888387 0.8817184225858201 1.0 1.0 1.0 0.1669998679965045 0.1163393066750141 0.9954762497320926 0.0367008373112137 12779 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +10 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7107166026857937 0.9845127857250529 0.8817184225858201 1.0 1.0 1.0 0.1484661470807383 0.1953008842632443 1.0 0.0288754988653259 12779 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +11 VWF ITGA9 VWF-ITGA9 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.7083995070560564 0.955713094717548 0.9404022517663844 1.0 1.0 1.0 0.1406138993850457 0.1048381933427708 1.0 0.0259018702558885 12779 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +13 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.6971282135184347 0.718867305289982 0.956444566971872 0.7204611100467462 1.0 1.0 0.2317164323896752 0.110891210066582 1.0 0.0536925050393989 16371 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +14 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.6965751554743362 0.7766289238087107 0.8817184225858201 1.0 1.0 1.0 0.1668262385778408 0.1243278593227725 0.9488962135774316 0.038422411769309 12779 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +16 CD48 CD2 CD48-CD2 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.6849877065459009 0.928447473463448 0.8960994285623033 1.0 1.0 1.0 0.1241603897223811 0.0943333961908353 1.0 0.0154158023760135 21212 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +17 CD34 SELP CD34-SELP Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.6842280929589697 0.9559599666576516 0.8819126042133903 1.0 1.0 1.0 0.1217138767253422 0.0964472963455669 1.0 0.0194068393458017 12779 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +18 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.6835286288881741 0.8718210606749883 0.878254460598671 1.0 1.0 1.0 0.1331963977536949 0.0960429871925293 1.0 0.0232412551842867 12779 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +20 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.6766771533392466 0.7324582304061453 0.942159351720962 0.7204611100467462 1.0 1.0 0.1930951050542117 0.0669171095229381 0.9861139184239592 0.0378107629344572 16371 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +24 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.6695148471220083 0.9184503888425788 0.8818326005152037 0.946515890536252 1.0 0.8672894033034337 0.135465098207694 0.1110232299264728 1.0 0.0303190087002372 11379 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +25 C3 LRP1 C3-LRP1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.6685524242873452 0.7148920381722296 0.7346293219749174 1.0 1.0 1.0 0.1700215762644027 0.0597298891744976 1.0 0.0289073363954321 94924 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +26 A2M LRP1 A2M-LRP1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.6652291956976334 0.8937519114898692 0.7346293219749174 0.7204611100467462 1.0 1.0 0.1832027437627448 0.0919553626930618 1.0 0.0369387462343996 13942 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +27 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.6620786139506267 0.8924110508951895 0.9255624071030766 0.6198216015396206 1.0 1.0 0.1645204742753035 0.1372136567327864 1.0 0.0430024129610479 11604 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +28 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.6616803690861207 0.8924110508951895 0.9008184599638702 0.6198216015396206 1.0 1.0 0.1684304172162009 0.1342601297358261 1.0 0.0450706652878317 11604 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +30 C1QB LRP1 C1QB-LRP1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.6604210530468991 0.9256868304646206 0.7346293219749174 0.7204611100467462 1.0 1.0 0.1693489539054447 0.1529500717654295 1.0 0.0644863645683822 9754 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +32 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.6533579344234645 0.724503440376099 0.8587566561291643 0.7204611100467462 1.0 1.0 0.1735345106193826 0.0716485451917006 1.0 0.0301142263759086 16371 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +38 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.6396824416127207 0.9184503888425788 0.896164124004365 1.0 1.0 1.0 0.0832421424982991 0.0834181078331637 1.0 0.0090773925972298 12779 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +39 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.6393086011414735 0.9356727248601746 0.8818326005152037 0.946515890536252 1.0 0.8672894033034337 0.1008001429589402 0.0687523801154171 0.9410019445502464 0.0178398804815888 11379 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +40 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.6381096730354273 0.9219165193585238 0.942159351720962 1.0 0.4529166025129413 1.0 0.171608073011602 0.0680804444792246 1.0 0.0385789185382267 12779 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +41 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.6372617129944409 0.7797302331085993 0.7763400818577846 1.0 0.8713412494740926 1.0 0.1269761760095012 0.0650418002388586 1.0 0.0161229492739958 21212 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +45 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.6339181063246662 0.7941469661104034 0.663300745568453 1.0 1.0 1.0 0.1231934200799743 0.0525758717990835 0.9012720659704488 0.0168391092146626 423716 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +100 COL4A2 CD93 COL4A2-CD93 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.5906347509655338 0.8840293712888387 0.8817184225858201 0.946515890536252 0.5544396796022323 1.0 0.1037851180436904 0.0874751670579747 0.7484955320458582 0.0251038468484739 11074 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +103 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.5891655536214562 0.7324582304061453 0.9694036398779844 0.7204611100467462 1.0 0.5444650460041837 0.1501605913349381 0.0508594367219704 1.0 0.0225482031900582 15611 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +181 COL4A1 CD93 COL4A1-CD93 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.5598041577740371 0.7766289238087107 0.8817184225858201 0.946515890536252 0.4857192596400828 1.0 0.0977597170391663 0.0895920947392859 0.6837855966286023 0.024381433989525 11074 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +215 CCN1 CAV1 CCN1-CAV1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.5487917643660586 0.9219165193585238 0.942159351720962 0.946515890536252 0.2646489893253856 1.0 0.1255542255158843 0.0582114261633864 0.8578239251554509 0.0320570706158569 11074 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +267 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.5337294016697339 0.9219165193585238 0.9694036398779844 0.946515890536252 0.4529166025129413 0.5444650460041837 0.1108190180252434 0.0475261446524304 0.9462437662348532 0.021443009051762 11379 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +344 CD48 CD2 CD48-CD2 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.5156182724507105 0.9011089648206808 0.8960994285623033 0.909150863993142 0.4567172527116189 1.0 0.0560470562093399 0.093818611720993 0.9955751809563635 0.0192535044755953 5921 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +476 A2M LRP1 A2M-LRP1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.4954417371114442 0.8937519114898692 0.7346293219749174 0.7204611100467462 0.3743986430148447 1.0 0.0835074846287301 0.0524806709306207 0.6214026938643678 0.0142559913693457 12977 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +559 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.4814674470281769 0.724503440376099 0.8587566561291643 0.7204611100467462 1.0 0.287457858136305 0.0966732225118063 0.0313534260030321 0.953568034406586 0.0098007815002242 15611 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +561 CCN1 CAV1 CCN1-CAV1 Pericytes Pericytes Pericytes -> Pericytes 0.4814463054892701 0.9219165193585238 0.9694036398779844 1.0 0.2646489893253856 0.5444650460041837 0.0967053677538771 0.0366773248068214 0.730244168013971 0.0175059952038369 12510 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +567 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.4809309681619716 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.7696906278989153 1.0 0.0546556267363012 0.0429723291185641 0.3676997418653926 0.0081241219229124 16371 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +600 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.4765155601675771 0.9184503888425788 0.8818326005152037 1.0 1.0 0.1993723722552783 0.0725029355718542 0.0308970446305136 1.0 0.0068862978323812 12779 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +626 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.4737150327472855 0.9356727248601746 0.8818326005152037 1.0 1.0 0.1993723722552783 0.0686954227713286 0.0246041682969455 1.0 0.0061820173722513 12779 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +696 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.46492511986833 0.8640667164982425 0.930308383061206 0.946515890536252 1.0 0.1615013370958009 0.0821901416867322 0.0302585903857984 1.0 0.0111609104490728 11379 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +709 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.4634130167593445 0.9356727248601746 0.6580560501976399 0.6198216015396206 1.0 1.0 0.025951090515396 0.0195319007163085 1.0 0.0039980009995002 6003 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +773 VWF ITGA9 VWF-ITGA9 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.457067659179789 0.955713094717548 0.7292496872084557 0.7204611100467462 1.0 0.2879885658616873 0.0630511883992014 0.0318331790143581 1.0 0.0043752689714531 13942 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +790 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.4551915332679501 0.8924110508951895 0.8950084308969304 0.6198216015396206 1.0 0.4247538686915498 0.0423027695685119 0.1089861866054952 1.0 0.0287986834887548 3646 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +800 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.4536962065819529 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.7029371915698084 0.8672894033034337 0.0308604021276835 0.0241389618431448 0.3303857989453059 0.0028825827941835 15611 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +850 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.4495541552479244 0.8640667164982425 0.956444566971872 0.946515890536252 0.1882781599600688 1.0 0.0560476028188531 0.0336655679971103 0.3890033374052296 0.0140870507495033 11074 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +876 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.4466313994350783 0.9184503888425788 0.6580560501976399 0.6198216015396206 1.0 1.0 0.0211889766771668 0.0212116164140152 1.0 0.0026653339996668 6003 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +925 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.4426772959234302 0.718867305289982 0.930308383061206 0.7204611100467462 1.0 0.1615013370958009 0.0967077025486599 0.0332409839215936 1.0 0.00935237973224 15611 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1003 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.4357449570220427 0.4629984640915818 0.7346293219749174 1.0 0.3309594876493178 1.0 0.0608095044867017 0.0275919566062221 0.2697998246953876 0.0137057014032278 94924 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1046 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.4331355469238935 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.4103175828613323 1.0 0.0444076421866602 0.1325942857142859 1.0 0.0432 3125 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1067 C1QB LRP1 C1QB-LRP1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.4316966067942702 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.8040181448318822 1.0 0.0203124545435482 0.0575352218225419 0.426751878540205 0.0185851318944844 3336 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1101 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.4292118601596522 0.9845127857250529 0.9003264838243337 0.946515890536252 1.0 0.1341680150528327 0.0555433238472552 0.0470750212379529 1.0 0.0050971087090253 11379 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1156 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.4263187193496752 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.4344545964241579 1.0 0.0384106377185263 0.1169919999999997 1.0 0.03232 3125 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1226 VWF ITGA9 VWF-ITGA9 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.4222625482334838 0.955713094717548 0.9404022517663844 0.946515890536252 1.0 0.1347191569099048 0.0494648600286711 0.0272032212448769 1.0 0.0040425344933649 11379 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1289 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.4182315618150244 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.454846709299195 1.0 0.0402288535944258 0.0369294135099523 0.2818530041465171 0.0057418606071712 16371 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1322 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.4162976647877334 0.8818165186409654 0.6207977546603366 0.6198216015396206 1.0 0.166956519448744 0.0918809113231974 0.2030504714364946 1.0 0.2 3005 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1355 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.414447570421636 0.8924110508951895 0.9008184599638702 0.6198216015396206 1.0 0.3180524283074206 0.0319778880135867 0.0787288684984788 1.0 0.0164563905650027 3646 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1409 VWF SELP VWF-SELP Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.4118195103530724 0.955713094717548 0.8819126042133903 0.946515890536252 1.0 0.0741032966028748 0.0825130904423486 0.0514464444071615 1.0 0.0112487916337112 11379 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1417 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.4115311790170933 0.9845127857250529 0.8817184225858201 0.946515890536252 1.0 0.1281708518900828 0.0461262198156699 0.0566174532032691 1.0 0.0035152473855347 11379 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1470 HSPG2 LRP1 HSPG2-LRP1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.4092930376661997 0.8818165186409654 0.7346293219749174 0.7204611100467462 0.1619074107723045 1.0 0.062213160622259 0.0296603820434443 0.2900253138958232 0.0169530708176003 12977 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1475 VWF SELP VWF-SELP Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.4089376243699279 0.9275752708651288 0.8819126042133903 0.946515890536252 0.1263644540569636 1.0 0.0477985506723533 0.0459019488728714 0.258105457281739 0.0154415748600325 11074 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1518 VWF LRP1 VWF-LRP1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.4068975939238189 0.955713094717548 0.6207977546603366 0.6198216015396206 1.0 0.166956519448744 0.0739201532809787 0.1553320223869307 1.0 0.1294509151414309 3005 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1533 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.4060684826522353 0.724503440376099 0.8587566561291643 0.7204611100467462 1.0 0.088850508457521 0.1125678984952072 0.0613960823373173 1.0 0.0268924302788844 10040 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1627 VEGFC FLT1 VEGFC-FLT1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.4019660610191693 0.8718210606749883 0.878254460598671 0.946515890536252 0.1796394187986057 1.0 0.0324010338839227 0.0349467220516525 0.4138905375346656 0.0044247787610619 11074 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1666 VWF LRP1 VWF-LRP1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.4004276733775736 0.9275752708651288 0.7346293219749174 0.7204611100467462 0.1263644540569636 1.0 0.0664494656401991 0.0377731230778926 0.2900035536919327 0.0193419126146258 12977 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1842 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.3937371563212535 0.8718210606749883 0.878254460598671 0.946515890536252 1.0 0.1332188634280341 0.038591964294895 0.0294548437179599 1.0 0.0024606731698743 11379 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +2000 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.3866682927070102 0.8840293712888387 0.8817184225858201 0.946515890536252 1.0 0.1281708518900828 0.0353441384445469 0.0276737850426222 0.7828486506628659 0.002636435539151 11379 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +2134 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.381969477007723 0.7766289238087107 0.8817184225858201 0.946515890536252 1.0 0.1281708518900828 0.0373861836088856 0.0318632066588829 0.7507900136950508 0.0030758414623429 11379 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +2163 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.3810655168490225 0.4648000335061383 0.7346293219749174 1.0 0.2966815529783992 1.0 0.0302254495143189 0.0209856481676569 0.2484826903434866 0.003676625510935 94924 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +2285 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.3765536772809564 0.7941469661104034 0.663300745568453 0.8824495942126559 0.0526353932596327 1.0 0.1165150621760833 0.0596861337709173 1.0 0.0198330716469713 12101 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +2348 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Pericytes Pericytes -> Pericytes 0.374527409593691 0.9356727248601746 0.8818326005152037 1.0 0.1750253929104546 0.8672894033034337 0.0220356658751005 0.0242672528643751 0.3321416959810656 0.0019984012789768 12510 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +2412 VWF LRP1 VWF-LRP1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.3720593277192054 0.955713094717548 0.9078204025796472 0.946515890536252 1.0 0.0350138403862125 0.0922524396313398 0.0289258921937539 1.0 0.014060989542139 11379 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +2507 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.3693052220748475 0.6303642896310324 0.956444566971872 0.6198216015396206 0.141548283585814 1.0 0.0479611763220357 0.1070879999999999 0.9720374031291382 0.05184 3125 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +2546 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.3682304126391739 0.8818165186409654 0.9078204025796472 0.946515890536252 1.0 0.0350138403862125 0.0939662537356179 0.0255502338615967 1.0 0.0145882766499692 11379 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +2558 A2M LRP1 A2M-LRP1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.3677212526315049 0.8937519114898692 0.6207977546603366 0.6198216015396206 1.0 0.166956519448744 0.0430600989728923 0.110981697171381 1.0 0.0439267886855241 3005 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +2686 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.364154745994082 0.9184503888425788 0.896164124004365 0.946515890536252 1.0 0.0855781119790033 0.0349769379567167 0.023112751559891 1.0 0.0020212672466824 11379 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +2696 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.3637790083280559 0.7324582304061453 0.7283139964676212 1.0 1.0 0.1449812920932466 0.029964851336494 0.0067520683213238 0.5534514945957221 0.0016223505119885 94924 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +2719 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.3631802558925118 0.7941469661104034 0.8891607331132086 0.7917001487310438 1.0 0.0606680526002441 0.0676598901432801 0.0282424812030051 0.9340064853671304 0.0049013157894736 30400 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +2734 VWF ITGA9 VWF-ITGA9 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.3629309434410416 0.9275752708651288 0.9404022517663844 0.946515890536252 0.1263644540569636 1.0 0.0219042343893377 0.0244142709376592 0.2726095588650278 0.0030702546505327 11074 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +2816 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.361141924840354 0.9468422434493456 0.9003264838243337 0.946515890536252 0.1120119983652299 1.0 0.0245469258401811 0.049801336463789 0.3145982757213117 0.0033411594726386 11074 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +2818 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.361094368295188 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.1932385901170197 1.0 0.0345246906947951 0.0611066666666665 0.8773946517339218 0.02976 3125 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +2830 CD34 SELP CD34-SELP Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.3608079834924606 0.9303167350027568 0.8819126042133903 0.946515890536252 0.1314667522621683 1.0 0.0216100788582925 0.0240653783637348 0.2910146487250415 0.0027993498284269 11074 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +2883 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.359581288775591 0.662063103571249 0.956444566971872 0.6198216015396206 0.585843718590581 1.0 0.0094010062256111 0.0153794458229942 0.1777084454093031 0.0045492142266335 4836 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +2917 VWF ITGA9 VWF-ITGA9 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.3587660057176224 0.955713094717548 0.7292496872084557 0.7204611100467462 1.0 0.2898144908728011 0.014653216049469 0.0505686023820739 1.0 0.0062916358253145 2702 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +2967 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.3574681204988301 0.6213271600240247 0.942159351720962 0.6198216015396206 0.2247035641022029 1.0 0.0255918875590897 0.0498773333333331 0.7350098198280862 0.01952 3125 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +3241 CD34 SELP CD34-SELP Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.351307641089321 0.9559599666576516 0.8819126042133903 0.946515890536252 1.0 0.0741032966028748 0.0317903031344412 0.0235521574830828 1.0 0.001669742508129 11379 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +3246 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Pericytes Pericytes -> Pericytes 0.35115285322855 0.9184503888425788 0.8818326005152037 1.0 0.1169448695751571 0.8672894033034337 0.0228239021239286 0.0293365307753797 0.307179935637042 0.0023181454836131 12510 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +3290 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.3500032016279152 0.9184503888425788 0.6580560501976399 0.6198216015396206 1.0 0.1973932010691654 0.0248607597333313 0.0642262895174708 1.0 0.0146422628951747 3005 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +3360 MMRN2 CD93 MMRN2-CD93 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.3479771309836911 0.9468422434493456 0.8817184225858201 0.946515890536252 0.1120119983652299 1.0 0.020058753860573 0.0501399674914213 0.298949885488063 0.0023478417915838 11074 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +3410 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.3468350125991324 0.7941469661104034 0.663300745568453 0.8824495942126559 1.0 0.0373075519081129 0.1003781964329312 0.0498013049699648 0.939695276893844 0.0160709801623838 11947 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +3464 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.3458248817661015 0.7148920381722296 0.8604147465201248 0.7204611100467462 1.0 0.0436001007095475 0.0885300912613741 0.0405502988047808 1.0 0.0166334661354581 10040 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +3815 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.3384352400172415 0.8924110508951895 0.4596166826058663 1.0 1.0 0.1076178292491983 0.0340414716820164 0.0130693071203372 1.0 0.0011588217942775 94924 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +3857 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.337552033717901 0.9356727248601746 0.6580560501976399 0.6198216015396206 1.0 0.1973932010691654 0.0196362410013873 0.0472545757071547 0.8578090283719569 0.0106489184692179 3005 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +3959 A2M LRP1 A2M-LRP1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.3355625102695632 0.8937519114898692 0.9078204025796472 0.946515890536252 1.0 0.0350138403862125 0.0530952663115144 0.0189493804376483 1.0 0.0046577027858335 11379 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +3966 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.3354372370754471 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.293296467876477 0.8672894033034337 0.0120805800461335 0.0381063352321767 0.5215548246179337 0.016053858104609 1931 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +3985 VWF ITGA9 VWF-ITGA9 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.3350345273185463 0.955713094717548 0.8794572885381431 0.8875000050982297 1.0 0.104965956217838 0.0180625048090418 0.0521540355196061 1.0 0.0104448742746615 2585 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +4007 C1QB LRP1 C1QB-LRP1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.3347114064661412 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.8040181448318822 0.166956519448744 0.0244869338458698 0.0789529461636286 0.8365576566750602 0.0275540483255616 2359 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +4027 COL4A2 CD93 COL4A2-CD93 Pericytes Pericytes Pericytes -> Pericytes 0.3344047175501929 0.8840293712888387 0.8817184225858201 1.0 0.5544396796022323 0.1281708518900828 0.025246080409561 0.0192645883293364 0.5449654594038704 0.0015987210231814 12510 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +4042 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.33419024696929 0.7324582304061453 0.942159351720962 0.7204611100467462 0.2376713873232418 1.0 0.0117887443377002 0.0359145527369826 0.5292494039326349 0.0111259457053849 2247 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +4118 CCN1 CAV1 CCN1-CAV1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.3326751612217194 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.4529166025129413 0.1449812920932466 0.0426747607849697 0.0113637450389709 0.9314600173936086 0.0021517716253048 13942 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +4263 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.3300082008229537 0.7797302331085993 0.7763400818577846 0.909150863993142 0.1132020978253244 1.0 0.0207329601256692 0.030569160614761 0.4853398433303413 0.0054044924843776 5921 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +4674 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.3230670265695335 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.293296467876477 1.0 0.0130258815452264 0.0130356558717696 0.7124238019363749 0.0019627085377821 5095 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +4680 C3 LRP1 C3-LRP1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.3229388797026536 0.7148920381722296 0.6207977546603366 0.6198216015396206 1.0 0.166956519448744 0.0246979605026514 0.0797071129707114 1.0 0.0466228332337118 1673 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +4685 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.3227714208634529 0.7941469661104034 0.663300745568453 0.8824495942126559 0.0323110954490285 1.0 0.0752865288881577 0.0423963133640541 0.7267708861047869 0.0114143920595533 12090 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +4742 C1QB LRP1 C1QB-LRP1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.321753674436406 0.9256868304646206 0.6207977546603366 0.6198216015396206 1.0 0.166956519448744 0.0186576308823113 0.0979966765140325 1.0 0.0406203840472673 1354 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +4817 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.3206418914516929 0.7941469661104034 0.663300745568453 0.8824495942126559 1.0 0.0265498740402422 0.0880557249615488 0.0397492274780117 1.0 0.0114808652246256 12020 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +4885 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.3195344548059231 0.6593525851613742 0.878254460598671 0.6198216015396206 0.4518617096918393 1.0 0.006562890289308 0.0268127929418252 0.3175565727479424 0.0012406947890818 4836 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +4910 VWF LRP1 VWF-LRP1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.319069074725439 0.955713094717548 0.8604147465201248 0.8875000050982297 1.0 0.0436001007095475 0.0331601731654974 0.0613900123087742 1.0 0.0352030947775628 2585 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +4944 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.3185992186232743 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.1836996873148393 1.0 0.018973735896014 0.0708721760309061 0.693002708789676 0.0634920634920634 1323 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +5018 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.3175949122656349 0.9067635403815892 0.956444566971872 1.0 0.0411127335336962 1.0 0.0287813219544369 0.0250449956960637 0.2273333387287306 0.0047734564519915 12779 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +5028 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.3174140191583969 0.8924110508951895 0.7754239189773715 0.7204611100467462 1.0 0.0521257226458961 0.0393540693205642 0.0255161173487866 1.0 0.0032868525896414 10040 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +5061 COL4A1 CD93 COL4A1-CD93 Pericytes Pericytes Pericytes -> Pericytes 0.316849900959001 0.7766289238087107 0.8817184225858201 1.0 0.4857192596400828 0.1281708518900828 0.0237357600253897 0.0194701381751741 0.45877320081682 0.0016786570743405 12510 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +5116 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.3161172948729644 0.7148920381722296 0.9078204025796472 0.7204611100467462 1.0 0.0350138403862125 0.0609534981336224 0.0127410159502915 1.0 0.0037153289347255 15611 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +5205 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.3147015769728767 0.7487535481622718 0.9255624071030766 0.6198216015396206 0.1027229557481577 1.0 0.0220147844817291 0.0467306360668711 0.3760628823810084 0.0130576713819368 4595 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +5274 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.3136762384599398 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.1027229557481577 1.0 0.0221808958274372 0.0443565139974281 0.3578994531055734 0.0139281828073993 4595 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +5362 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.3124512937464492 0.724503440376099 0.7373999388878224 1.0 1.0 0.0455125113141721 0.0382665566549097 0.0047792620060961 1.0 0.0014643293582234 94924 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +5460 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.3109287345123636 0.9184503888425788 0.4638256179742202 0.7204611100467462 1.0 0.0689186266365139 0.0427176521349819 0.0118825610864055 1.0 0.0020083201836178 13942 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +5531 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.3099727485185487 0.9356727248601746 0.4638256179742202 0.7204611100467462 1.0 0.0689186266365139 0.0411637595907485 0.0087624922297135 1.0 0.0018648687419308 13942 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +5532 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.3099703916417245 0.9356727248601746 0.4638256179742202 0.2461374514707439 1.0 0.5131068416842878 0.0161829149819189 0.0471084337349397 1.0 0.013012048192771 2075 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +5695 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.3080098124208328 0.8818165186409654 0.8604147465201248 0.8875000050982297 1.0 0.0436001007095475 0.0290833957964092 0.0491618310767246 1.0 0.0270793036750483 2585 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +5852 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.3061608790841568 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.7029371915698084 0.1993723722552783 0.0126767438441394 0.0066886567711196 0.2923129989371771 0.0005497526113249 16371 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +5867 VWF ITGA9 VWF-ITGA9 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.3060225802405379 0.955713094717548 0.6252253442669611 0.6198216015396206 1.0 0.1886404570313 0.0117558696409605 0.0444167704441676 1.0 0.0076103500761035 1971 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +5945 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.305050446151841 0.8924110508951895 0.7757991160529997 0.7204611100467462 1.0 0.0491709261488903 0.0328546310365224 0.02333846432452 1.0 0.0022908366533864 10040 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +6041 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.3039439541320102 0.6213271600240247 0.9694036398779844 0.6198216015396206 0.2247035641022029 0.5444650460041837 0.0172619200230981 0.0370589006952643 0.7378413297114995 0.0133805588351042 2541 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +6049 A2M LRP1 A2M-LRP1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.3039163495424286 0.4648000335061383 0.7346293219749174 0.8293805866303694 0.2100317344087863 1.0 0.0132480151927338 0.0244777916724561 0.2898317688282484 0.0025010421008753 7197 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +6077 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.3034730662761469 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.2545335314555431 1.0 0.0104335039289756 0.0576769025367156 0.4935218222831662 0.0093457943925233 2247 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +6107 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Pericytes Pericytes -> Pericytes 0.3032160526783609 0.8640667164982425 0.930308383061206 1.0 0.1882781599600688 0.1615013370958009 0.031795280384 0.0104066746602717 0.3929015048487793 0.0035171862509992 12510 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +6168 C1QB LRP1 C1QB-LRP1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.3025337682800985 0.8703788833238396 0.6207977546603366 1.0 0.8040181448318822 0.0501711964086628 0.0351774309065921 0.0446116928446771 1.0 0.0164547494390426 4011 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +6318 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.3008455022020168 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.1928969878996252 1.0 0.0090356794529776 0.0574468085106383 0.4915529852261857 0.0124113475177304 1692 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +6410 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.29992905422167 0.6589792304505506 0.6207977546603366 1.0 0.1836996873148393 0.166956519448744 0.0580199595987389 0.0725594151825977 0.4070490678047991 0.063054559184444 5297 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +6423 C1QB LRP1 C1QB-LRP1 Macrophages Macrophages Macrophages -> Macrophages 0.2997676184961432 0.9256868304646206 0.8604147465201248 1.0 1.0 0.0436001007095475 0.020895297435547 0.0487184703010577 1.0 0.0154597233523189 2458 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +6544 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.2984150980671512 0.9097736029185508 0.663300745568453 0.7917001487310438 0.0430965463818576 1.0 0.0342986867668322 0.0213779061613048 0.3664667649402147 0.0032101135122613 30217 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +6589 CCN1 CAV1 CCN1-CAV1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.2979017327716951 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.2646489893253856 0.1449812920932466 0.0376560702846164 0.0105622768487837 0.865765515113591 0.0020806041457964 12977 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +6627 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.2973258087461923 0.9184503888425788 0.4638256179742202 0.2461374514707439 1.0 0.5131068416842878 0.0128410143453964 0.0518875502008032 1.0 0.0081927710843373 2075 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +6650 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.2969871447635298 0.4619393085577573 0.956444566971872 0.7204611100467462 0.1194227711616854 1.0 0.0180502488286959 0.0104911123327835 0.1212240860126367 0.0026876794331439 16371 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +6849 VWF ITGA9 VWF-ITGA9 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.2946761939776005 0.955713094717548 0.6252253442669611 0.6198216015396206 1.0 0.1112417752963437 0.0158917325078751 0.0107067678282071 1.0 0.0014992503748125 6003 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +6941 VWF LRP1 VWF-LRP1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.2937213984545734 0.955713094717548 0.9078204025796472 1.0 1.0 0.0144359394371152 0.0512673173987894 0.0132399391046389 1.0 0.0034431489161906 12779 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +6951 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.2935729774291079 0.9184503888425788 0.6571792026963191 0.6198216015396206 1.0 0.1615138601457002 0.0105944883385834 0.0118274196235215 1.0 0.0006663334999167 6003 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +7171 CD48 CD2 CD48-CD2 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.291124352785587 0.9426443637490616 0.8960994285623033 0.9318789094584046 0.0632786830726401 1.0 0.0122222111781137 0.0317953861584754 0.3374031735029234 0.0038114343029087 4985 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +7198 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.2908132961594413 0.662063103571249 0.956444566971872 0.6198216015396206 0.0967042147306326 1.0 0.0159372693522835 0.03344 0.3863969146145828 0.0144 3125 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +7387 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.2887270744576181 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.7696906278989153 0.1281708518900828 0.019965217408857 0.0129395938761128 0.3660411320836287 0.0010889757222471 15611 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +7570 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.287144239376444 0.9184503888425788 0.896164124004365 0.946515890536252 0.1169448695751571 1.0 0.0061524422627681 0.0265486725663716 0.3656191535340088 0.0001806032147372 11074 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +7595 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.2869095678655378 0.8818165186409654 0.9078204025796472 1.0 1.0 0.0144359394371152 0.0482665834660766 0.0120336315656763 1.0 0.0030518819938962 12779 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +7664 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.2861440591375495 0.6605327397359113 0.657421674383923 1.0 1.0 0.3162217004298525 0.0039973966411222 0.0024493607353352 0.2821097580518173 5.664171284539644e-05 423716 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +7735 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.2855476431660791 0.9356727248601746 0.7746834992804791 0.6198216015396206 1.0 0.2295016807597237 0.0052573847303627 0.0156857771013022 1.0 0.0015220700152207 1971 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +7786 A2M LRP1 A2M-LRP1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.28514111053877 0.8937519114898692 0.8604147465201248 0.8875000050982297 1.0 0.0436001007095475 0.0180625048090418 0.0383301096067053 1.0 0.0104448742746615 2585 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +7833 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.28466486594237 0.9184503888425788 0.7746834992804791 0.6198216015396206 1.0 0.2295016807597237 0.0052573847303627 0.0229156096736005 1.0 0.0015220700152207 1971 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +7870 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2843014185147333 0.8818165186409654 0.6207977546603366 0.6198216015396206 1.0 0.0501711964086628 0.0310187560216319 0.0661783956435228 1.0 0.0457115928369462 2122 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +8036 CD34 SELP CD34-SELP CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.2826071800283431 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.1173076386135379 1.0 0.009535059224416 0.0094679616394844 0.114492923776708 0.000794087105247 16371 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +8142 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.2815362627531766 0.7324582304061453 0.7283139964676212 0.8293805866303694 1.0 0.1176565474247238 0.0095660809162954 0.0057546693589096 0.3952864943111414 0.000504795557799 9905 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +8304 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.2799087825858661 0.9845127857250529 0.944024288971064 0.8875000050982297 1.0 0.0484215930647349 0.0120416698726945 0.0522243713733075 1.0 0.004642166344294 2585 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +8407 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.2790340140471977 0.8818165186409654 0.6207977546603366 0.6198216015396206 1.0 0.0587195251380622 0.0236899961119013 0.016160901030966 1.0 0.0033316674995835 6003 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +8438 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.2787492907578485 0.7324582304061453 0.9694036398779844 0.7204611100467462 0.2376713873232418 0.5444650460041837 0.0070865852081796 0.0232867253581909 0.463637832762528 0.0062143966856551 1931 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +8483 VWF LRP1 VWF-LRP1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2783265286346819 0.955713094717548 0.6207977546603366 0.6198216015396206 1.0 0.0501711964086628 0.0251958199790235 0.0580284465769856 1.0 0.0301602262016965 2122 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +8519 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.2779065370225409 0.718867305289982 0.9015117569158254 0.7204611100467462 1.0 0.0246995741084876 0.0399458930459935 0.0217604581673307 1.0 0.0033864541832669 10040 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +8588 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.2771945406287731 0.9356727248601746 0.8818326005152037 0.946515890536252 0.1750253929104546 0.1993723722552783 0.0166457606816437 0.009421467702125 0.4117444761539059 0.0011739208957919 11074 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +8590 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.2771586557088336 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.1661175896787547 1.0 0.008380349413725 0.0048537798810823 0.2652684568124886 0.0002647516298772 30217 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +8603 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.2770305337845712 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0637288077574987 1.0 0.0169662872056299 0.0478771454381212 0.3863063758696891 0.014453477868112 3321 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +8697 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.276182439180976 0.6160088550075702 0.9008184599638702 0.7917001487310438 0.0548063857429699 1.0 0.0184314671554747 0.0799209486166008 0.6448582456957406 0.0213043478260869 2300 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +8855 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.2748314975096953 0.7797302331085993 0.7763400818577846 0.9318789094584046 0.8713412494740926 0.0467761235673353 0.0187426205303911 0.0182302062541583 1.0 0.0029940119760479 5010 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +8992 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.2735918735428933 0.7487535481622718 0.9255624071030766 0.6198216015396206 0.0637288077574987 1.0 0.0153204557705016 0.050778790616189 0.4086402405398361 0.0111412225233363 3321 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +9030 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.2732532713149596 0.6605327397359113 0.7763400818577846 0.7917001487310438 1.0 1.0 0.001025370629659 0.017130189439742 0.2719722521556211 0.0012091898428053 827 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +9113 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.2726557372976441 0.7148920381722296 0.6207977546603366 0.6198216015396206 1.0 0.0501711964086628 0.0297697936209658 0.0386725178277565 1.0 0.0142622051563357 3646 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +9285 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.2711178774630263 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.8713412494740926 0.0761275033764692 0.0266823653299174 0.0116585470478291 1.0 0.0012868829855685 10879 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +9317 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.2708603272005018 0.7766289238087107 0.944024288971064 0.8875000050982297 1.0 0.0484215930647349 0.0125333673753919 0.0304504006631666 1.0 0.0050290135396518 2585 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +9380 A2M LRP1 A2M-LRP1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.2704207366769754 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.3743986430148447 0.166956519448744 0.018191486009524 0.0666244547629098 0.6496535579010535 0.0194174757281553 2369 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +9386 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.2703509972465744 0.8818165186409654 0.7346293219749174 0.7204611100467462 1.0 0.0416128058995347 0.0201040465621716 0.0338124023357184 1.0 0.0118430792005921 2702 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +9398 A2M LRP1 A2M-LRP1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.2702534549291304 0.919551140852988 0.7346293219749174 0.7204611100467462 0.037376181609614 1.0 0.0214179335922776 0.0229649374615542 0.2719186654816602 0.003793315562846 9754 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +9431 C1QB LRP1 C1QB-LRP1 Macrophages Pericytes Macrophages -> Pericytes 0.2699619190033646 0.9256868304646206 0.9078204025796472 0.8875000050982297 1.0 0.0350138403862125 0.0148232170573193 0.0305931689571544 1.0 0.00767987065481 2474 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +9495 CD48 CD2 CD48-CD2 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.2694803856579821 0.928447473463448 0.8960994285623033 0.909150863993142 1.0 0.0229905310518441 0.0220223701810416 0.0220333102012491 1.0 0.0031228313671061 5764 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +9502 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.2694180621042831 0.6160088550075702 0.9255624071030766 0.7917001487310438 0.0548063857429699 1.0 0.0154587834853839 0.0690513833992095 0.5556881835792549 0.017391304347826 2300 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +9579 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2687692322036022 0.8840293712888387 0.7779918296243433 0.6198216015396206 1.0 0.0627790816848129 0.0140848915554859 0.0476908576814326 1.0 0.0094250706880301 2122 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +9615 VWF LRP1 VWF-LRP1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.2684223664559202 0.955713094717548 0.7346293219749174 0.7204611100467462 1.0 0.0416128058995347 0.017769634566752 0.0282114258798196 1.0 0.0092524056254626 2702 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +9678 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.2679080426100882 0.8924110508951895 0.7754239189773715 0.7204611100467462 1.0 0.0293031867940321 0.0253095625063535 0.0082575806104087 1.0 0.000640573954263 15611 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +9725 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.267537560534791 0.6213271600240247 0.942159351720962 0.6198216015396206 0.1153131738111426 1.0 0.0087643090919447 0.0313829787234042 0.4624705451472575 0.0124113475177304 1692 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +9780 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2670560746569175 0.7766289238087107 0.7779918296243433 0.6198216015396206 1.0 0.0627790816848129 0.0154292256499073 0.0520398545846236 1.0 0.0113100848256361 2122 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +9795 VWF LRP1 VWF-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.2669292773650434 0.955713094717548 0.6207977546603366 0.6198216015396206 1.0 0.0587195251380622 0.0167513568970083 0.0112405918252994 1.0 0.0016658337497917 6003 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +9803 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.2668439382963382 0.8924110508951895 0.9460955677032749 0.6198216015396206 1.0 0.0376195773145198 0.0183384704639989 0.0305250042962709 1.0 0.0040170132325141 4232 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +9821 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.266697322013456 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.1932385901170197 0.287457858136305 0.0194958934035866 0.0332382264200446 1.0 0.0125934671389216 2541 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +9895 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.2660938390500192 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.1661175896787547 0.8672894033034337 0.0072128515763061 0.0322148271399519 0.4409187715560569 0.0077648363838047 1803 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +10142 C3 LRP1 C3-LRP1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.2643353373846708 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0691889863216023 1.0 0.0171335391254573 0.026566247002398 0.4706266196194986 0.0119904076738609 3336 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +10292 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.26301883496362 0.8924110508951895 0.9546923450729716 0.6198216015396206 1.0 0.0445745465878424 0.0140649647948987 0.0290213095033511 1.0 0.0023629489603024 4232 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +10314 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.2628555588214097 0.8840293712888387 0.944024288971064 0.8875000050982297 1.0 0.0484215930647349 0.0091969772808819 0.0276208897485493 1.0 0.0027079303675048 2585 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +10426 VWF ITGA9 VWF-ITGA9 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.2620614878084487 0.955713094717548 0.6252253442669611 0.6198216015396206 1.0 0.0565946652887153 0.01545298983046 0.032007260626229 1.0 0.005657237936772 3005 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +10427 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.2620613582829755 0.7296454584598743 0.4638256179742202 0.2461374514707439 0.7029371915698084 0.5131068416842878 0.0107807464745703 0.0162697032916087 0.392965536312057 0.0019123783031988 5752 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +10636 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.260482139222248 0.718867305289982 0.7167436199046466 0.8767341187813953 1.0 0.0326667674102811 0.0211680427522902 0.0476966979209131 0.9531217126863998 0.0167142274765593 2453 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +10687 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.2600900165870228 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.293296467876477 0.2295016807597237 0.0131264143938915 0.0097575757575757 0.6701899204074633 0.0011636363636363 6875 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +10722 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.2598493918247145 0.7324582304061453 0.7283139964676212 1.0 0.2376713873232418 0.1176565474247238 0.0206364707131742 0.0069317114619202 0.4761371596643676 0.0008944143821832 22361 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +10725 MMP2 PECAM1 MMP2-PECAM1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.2598309416297998 0.9067635403815892 0.956444566971872 0.946515890536252 0.0216588811659259 1.0 0.0173072055478705 0.0177081452049846 0.1607367723674644 0.00325085786527 11074 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +10748 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.2597129597954631 0.8924110508951895 0.4596166826058663 0.8767341187813953 1.0 0.0484993884807927 0.017595291903499 0.0774005855538673 1.0 0.0110069302894415 2453 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +10904 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.2586309786549386 0.9184503888425788 0.4641352222874551 0.7204611100467462 1.0 0.1370986982961073 0.0071078538267008 0.0355292376017764 1.0 0.001480384900074 2702 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +11036 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.2578361725447182 0.9845127857250529 0.7154802332407408 0.7204611100467462 1.0 0.0292771742399634 0.019774430480829 0.0098981494764022 1.0 0.0004303543250609 13942 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +11047 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.2577416052266298 0.9184503888425788 0.7754072541855492 0.6198216015396206 1.0 0.0826982152707935 0.0080307878281307 0.030441400304414 1.0 0.0035514967021816 1971 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +11056 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.2576768435664414 0.7797302331085993 0.7763400818577846 0.909150863993142 0.8713412494740926 0.0293997450046583 0.0207628897237533 0.0183032616238723 1.0 0.0027758501040943 5764 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +11164 CD48 CD2 CD48-CD2 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.256739947206597 0.928447473463448 0.937587088419394 0.9318789094584046 1.0 0.0275738893167071 0.0128036473199988 0.024750499001996 1.0 0.0013972055888223 5010 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +11321 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.2555719532636472 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.4103175828613323 0.1281708518900828 0.0146219200526899 0.04492044751785 1.0 0.0070838252656434 2541 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +11368 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.2553229737440096 0.9356727248601746 0.6580560501976399 0.6198216015396206 0.1750253929104546 1.0 0.0041474737325165 0.0048834735518808 0.2668912733436848 0.0002901073397156 6894 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +11593 A2M LRP1 A2M-LRP1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2536328303115466 0.8937519114898692 0.6207977546603366 0.6198216015396206 1.0 0.0501711964086628 0.0154292256499073 0.0398601947847942 1.0 0.0113100848256361 2122 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +11614 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.2534720116951006 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.454846709299195 0.1281708518900828 0.015553474893586 0.0114479716683291 0.2697475774381674 0.0008968035359682 15611 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +11654 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.2532434012601838 0.7148920381722296 0.9078204025796472 0.7204611100467462 1.0 0.0144359394371152 0.03907800643602 0.0065405289841793 1.0 0.0015270905870136 16371 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +11715 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.252790039084885 0.7797302331085993 0.657421674383923 0.7917001487310438 0.8713412494740926 0.3162217004298525 0.0023336127159896 0.0088698140200286 1.0 0.0008583690987124 1165 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +11864 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.2518206276737678 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.293296467876477 0.1973932010691654 0.0148001787984672 0.0569248826291079 1.0 0.0192061459667093 1562 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +11921 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.2514038072087484 0.6160088550075702 0.9255624071030766 1.0 0.0255753403203798 1.0 0.0173147640265342 0.0161272350127712 0.1297832641323334 0.0023100132000754 21212 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +12025 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2507134890517833 0.9845127857250529 0.7779918296243433 0.6198216015396206 1.0 0.0627790816848129 0.0083327342178561 0.0533694627709707 1.0 0.0032987747408105 2122 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +12135 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.2501183081099981 0.8718210606749883 0.4630488285702799 0.7204611100467462 1.0 0.0521374123931907 0.0161457548773899 0.006192320566155 1.0 0.0002869028833739 13942 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +12161 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.2499270214626679 0.8924110508951895 0.7757991160529997 0.7204611100467462 1.0 0.0279580382843415 0.017476215763223 0.0077326314269689 1.0 0.0003054181174027 16371 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +12199 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.2496530097017176 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.2159908053119969 0.8672894033034337 0.0037835435187952 0.0078495000877039 0.1074347511151889 0.0008770391159445 5701 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +12240 A2M LRP1 A2M-LRP1 Pericytes Pericytes Pericytes -> Pericytes 0.249362068152309 0.8937519114898692 0.9078204025796472 1.0 0.3743986430148447 0.0350138403862125 0.0226043003544684 0.0093525179856115 0.5461012950953527 0.0012789768185451 12510 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +12267 A2M LRP1 A2M-LRP1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.2492035913373062 0.8937519114898692 0.9078204025796472 1.0 1.0 0.0144359394371152 0.0204485856550684 0.0086143934058481 1.0 0.0005477736912121 12779 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +12372 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.2484984300971814 0.6249837837987587 0.7746834992804791 1.0 0.1661175896787547 0.2295016807597237 0.0127569527777678 0.005797915815284 0.3982243986942668 0.0004086636697997 19576 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +12443 C3 LRP1 C3-LRP1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.2480385228211889 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0616816618657801 1.0 0.0131193211532481 0.0424603174603174 0.7521934006153048 0.0279667422524565 1323 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +12478 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.2478247932532757 0.6605327397359113 0.657421674383923 0.8824495942126559 0.1468839381042521 0.3162217004298525 0.0130158899562927 0.0065008401509517 0.748746567078257 0.0003305511941161 12101 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +12528 C1QB LRP1 C1QB-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.2474292675707023 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.8040181448318822 0.0587195251380622 0.0113615698732313 0.0132129277566539 1.0 0.0017743979721166 3945 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +12594 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.2470548727219067 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.149715856631667 1.0 0.0068242338544767 0.0108152361254739 0.1717111265457368 0.0004308859014133 11604 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +12632 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.2468263254297463 0.718867305289982 0.6331674633943454 0.6198216015396206 1.0 0.0518891167572028 0.015446787425078 0.0285312671420735 1.0 0.0038398244651673 3646 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +12707 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.2464534947090775 0.7487535481622718 0.9255624071030766 0.6198216015396206 0.0338862305197021 1.0 0.0153948295140271 0.04517490339638 0.3635431873474978 0.0109060402684563 3576 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +12851 VEGFC FLT1 VEGFC-FLT1 Pericytes Pericytes Pericytes -> Pericytes 0.2456024735673943 0.8718210606749883 0.878254460598671 1.0 0.1796394187986057 0.1332188634280341 0.0119779059691058 0.0092992272848388 0.3504893364543804 0.0005595523581135 12510 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +12923 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.2451733016714267 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.293296467876477 0.1993723722552783 0.008012316052045 0.0155392375018543 0.6791081185353925 0.0040053404539385 2247 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +13010 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.2446533163133222 0.7800321422220979 0.956444566971872 0.6198216015396206 0.1357656553382984 1.0 0.0034156737811844 0.0159574468085106 0.1843872072947019 0.0047281323877068 1692 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +13076 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.2442191844306034 0.7324582304061453 0.62431395375366 0.6198216015396206 1.0 0.0649213179279442 0.0115302374499306 0.0256027097031281 1.0 0.0101613867304243 1673 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +13100 C3 LRP1 C3-LRP1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.2440803522283965 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0334108479684367 1.0 0.0219918677935627 0.0145096056622851 0.2570406977032476 0.0034010478904311 10879 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +13169 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.2436252897080405 0.8924110508951895 0.7754239189773715 0.7204611100467462 1.0 0.0178869147172998 0.023446803861612 0.0061333511031147 1.0 0.0005497526113249 16371 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +13215 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.2432747069988014 0.6160088550075702 0.9008184599638702 1.0 0.0255753403203798 1.0 0.0146061449901171 0.0160243772821557 0.12929591053917 0.0016500094286253 21212 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +13220 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.2432422351260049 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.4344545964241579 0.1281708518900828 0.0103392588232246 0.0371507280598189 1.0 0.0035419126328217 2541 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +13283 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.2429153795203883 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.1740454925211078 1.0 0.0032813727225905 0.0139164598842018 0.1190784584420053 0.0008271298593879 4836 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +13292 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.2428755050036719 0.8533682807143209 0.8817184225858201 0.6198216015396206 0.0706049302656684 1.0 0.006233520219923 0.0402313407632557 0.3070540032245558 0.0094562647754137 1692 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +13708 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.2402210812499011 0.8924110508951895 0.4600037439857229 0.8767341187813953 1.0 0.0292791515533623 0.0182353285704089 0.0434347552162473 1.0 0.0118222584590297 2453 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +13963 A2M LRP1 A2M-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.2387653265459305 0.8937519114898692 0.6207977546603366 0.6198216015396206 1.0 0.0587195251380622 0.0091750960413112 0.0081695263479371 1.0 0.0004997501249375 6003 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +14160 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.2375280645129427 0.7296454584598743 0.4638256179742202 0.2461374514707439 0.293296467876477 0.5131068416842878 0.0143261754890835 0.0109074362974519 0.2634495834124071 0.0010140405616224 12820 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +14326 A2M LRP1 A2M-LRP1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.2365643169396443 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.093381536992618 1.0 0.0053246820491184 0.0170613509192645 0.2020166517347327 0.0026978417266187 3336 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +14557 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.23514319940548 0.2451358214448441 0.4614667734221426 1.0 0.1327555461750915 0.1609352200462838 0.0699428617139537 0.031329517418949 0.6581698656208567 0.0074327375959739 77495 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +14634 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.2347357149944721 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0338862305197021 1.0 0.0118088709686737 0.0369254626804964 0.2979405212002501 0.0078299776286353 3576 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +14636 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.2347167408409528 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.0839650520556947 1.0 0.0068087463360849 0.0361434293343505 0.2758542086052534 0.0071206052514463 2247 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +14856 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.2335504891023133 0.4629984640915818 0.7346293219749174 0.8293805866303694 0.0683610513379333 1.0 0.0084153788933494 0.0143520448334953 0.1403372452109542 0.0020842017507294 7197 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +14893 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.2333987475145532 0.8924110508951895 0.4600037439857229 1.0 1.0 0.0310998965832685 0.012662089253084 0.0050403959531261 0.9511889336073864 0.0001685558973494 94924 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +14968 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.2330136074250389 0.4630253981438691 0.944024288971064 0.7204611100467462 0.7696906278989153 0.0484215930647349 0.0136374593789017 0.0118824701195219 0.4403105362390874 0.0008964143426294 10040 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +15001 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.2328006023656648 0.9184503888425788 0.8818326005152037 0.946515890536252 0.1169448695751571 0.1993723722552783 0.0089061114404891 0.0103395340437059 0.3830717271381121 0.0003612064294744 11074 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +15024 HSPG2 LRP1 HSPG2-LRP1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.2326206469525401 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.1619074107723045 0.166956519448744 0.0172752383012337 0.0565170489189061 0.3170534384769468 0.0358801181933305 2369 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +15039 VWF ITGA9 VWF-ITGA9 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.232536994752287 0.9275752708651288 0.7292496872084557 0.7204611100467462 0.1263644540569636 0.2879885658616873 0.0089148831007635 0.0071104821817621 0.2620326183917206 0.0003852970640363 12977 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +15083 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.232275665764383 0.8640667164982425 0.9015117569158254 0.8875000050982297 1.0 0.0246995741084876 0.0091969772808819 0.0117504835589941 1.0 0.0027079303675048 2585 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +15114 A2M LRP1 A2M-LRP1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.2321237040487429 0.8937519114898692 0.7346293219749174 0.7204611100467462 1.0 0.0416128058995347 0.0079468221653175 0.0185510732790525 1.0 0.0018504811250925 2702 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +15169 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.2317592854023136 0.7941469661104034 0.8445107771175474 0.7917001487310438 1.0 0.0218093597373452 0.0133817402216567 0.0175311791383221 0.9501081120274408 0.0035714285714285 3360 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +15214 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.2315019704526344 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.1098969873322313 1.0 0.0046880639355817 0.0300138573948097 0.355382115122955 0.0075585789871504 1323 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +15442 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.2302661953473362 0.6213271600240247 0.942159351720962 0.6198216015396206 0.1339639999453202 1.0 0.0030667623592967 0.0070581748001103 0.1040117312101202 0.0008271298593879 4836 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +15452 C1QB LRP1 C1QB-LRP1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.2302136122373498 0.9256868304646206 0.6207977546603366 0.6198216015396206 1.0 0.0501711964086628 0.0083300954346337 0.0307868998221695 0.7332836226348153 0.0071132187314759 1687 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +15502 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.2299063220610715 0.6303642896310324 0.930308383061206 0.6198216015396206 0.141548283585814 0.1615013370958009 0.0177721180068875 0.0286993309720582 0.8863817730675125 0.011806375442739 2541 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +15554 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2296322256117279 0.8640667164982425 0.6331674633943454 0.6198216015396206 1.0 0.0518891167572028 0.0083327342178561 0.02188383600377 1.0 0.0032987747408105 2122 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +15562 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.2295991108957783 0.9184503888425788 0.6580560501976399 0.6198216015396206 0.1169448695751571 1.0 0.0033439007806524 0.0063823614737452 0.3469795236208066 0.0001450536698578 6894 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +15730 VWF SELP VWF-SELP Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.2287165603355474 0.955713094717548 0.7760344326192508 0.6198216015396206 1.0 0.0335947364052305 0.0092691214683052 0.0216045108319319 1.0 0.0008705114254624 4595 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +15980 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.2274740359286382 0.2534163760166434 0.4638256179742202 1.0 0.2100740470724093 0.5131068416842878 0.0109350538448267 0.0083403230315934 0.2014455613837975 0.0005935866830118 77495 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +16157 COL4A2 CD93 COL4A2-CD93 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.2265670816493775 0.8840293712888387 0.7779918296243433 0.6198216015396206 0.5544396796022323 0.0627790816848129 0.0091159638047366 0.0366687777074097 0.8041987221843785 0.0088663711209626 1579 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +16244 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Pericytes Pericytes -> Pericytes 0.2261048493439869 0.9468422434493456 0.9003264838243337 1.0 0.1120119983652299 0.1341680150528327 0.010429597990015 0.0106714628297362 0.2657346260765795 0.0005595523581135 12510 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +16274 COL4A2 CD93 COL4A2-CD93 Pericytes Macrophages Pericytes -> Macrophages 0.2259101282355507 0.8840293712888387 0.944024288971064 0.8875000050982297 0.5544396796022323 0.0484215930647349 0.0066850066930874 0.0242823529411765 0.899794044262776 0.0023529411764705 2125 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +16344 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.2254361886270531 0.8924110508951895 0.4596166826058663 0.8293805866303694 1.0 0.0292373734098458 0.0131973992492685 0.0061585058051489 0.9404389314805246 0.0004038364462392 9905 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +16375 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.2252747537632307 0.7797302331085993 0.885766439573873 0.6198216015396206 0.8713412494740926 0.0331922776397286 0.0105564755330948 0.0102768456375838 1.0 0.0010486577181208 4768 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +16451 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.2249224626259126 0.4629984640915818 0.8604147465201248 0.7204611100467462 0.3309594876493178 0.0436001007095475 0.0312634168089899 0.0141600265604247 0.3254074973564766 0.0063745019920318 10040 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +16578 C3 LRP1 C3-LRP1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.2242834912704608 0.7148920381722296 0.6207977546603366 0.6198216015396206 1.0 0.0104714078116759 0.0441896875048812 0.0108044639779386 1.0 0.0031023784901758 11604 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +16580 VWF ITGA9 VWF-ITGA9 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2242553689254372 0.955713094717548 0.6252253442669611 0.6198216015396206 1.0 0.0487643047611538 0.0070424457777429 0.0302030674320966 1.0 0.0023562676720075 2122 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +16647 COL4A1 CD93 COL4A1-CD93 Pericytes Macrophages Pericytes -> Macrophages 0.2239549982724768 0.7766289238087107 0.944024288971064 0.8875000050982297 0.4857192596400828 0.0484215930647349 0.0082446917951736 0.0252436974789916 0.8553981162895373 0.0037647058823529 2125 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +17059 COL4A1 CD93 COL4A1-CD93 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.221810647487485 0.7766289238087107 0.6587114738285964 0.6198216015396206 1.0 0.0289462771086338 0.012975545257698 0.0076509364365436 1.0 0.000999500249875 6003 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +17076 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.2217647234253946 0.6213271600240247 0.62431395375366 1.0 0.2247035641022029 0.0649213179279442 0.0210200526431664 0.0173242716002768 0.7137826334442787 0.0047196526335661 5297 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +17244 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.2208680242409549 0.8978557803479422 0.7763400818577846 0.6198216015396206 0.0477973731763516 1.0 0.0056216896052045 0.0170115585384041 0.2700887754126695 0.0019574944071588 3576 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +17487 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.2197472953257148 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.1671376945154473 1.0 0.0019112815357316 0.0275 0.3256165323012191 0.00375 800 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +17548 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.2194810792062979 0.4636527906642655 0.878254460598671 0.7204611100467462 0.0693389464442948 1.0 0.0054951635230675 0.0083480952090078 0.0988704350679843 0.0003054181174027 16371 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +17559 COL4A1 CD93 COL4A1-CD93 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.2194143741721788 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.4857192596400828 0.0627790816848129 0.0097708945026434 0.0402605627431466 0.8084159915262933 0.0101329955668144 1579 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +17580 VWF ITGA9 VWF-ITGA9 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.2193280115986386 0.955713094717548 0.863034163938375 0.8567148457705164 1.0 0.0627102121186242 0.0025120755941354 0.1422222222222222 1.0 0.0266666666666666 225 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +17602 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.2192086148001291 0.7941469661104034 0.663300745568453 0.8824495942126559 1.0 0.0222186841038061 0.0107429975498009 0.0167089743197644 0.6607230520253873 0.0017126953543138 4671 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +17609 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.2191865440175115 0.6160088550075702 0.8950084308969304 0.7917001487310438 0.0548063857429699 0.4247538686915498 0.0109128834085982 0.0459403785611568 0.473575616065185 0.009833262077811 2339 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +17645 C3 LRP1 C3-LRP1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.2189587113671897 0.6319926036888139 0.6207977546603366 1.0 0.0616816618657801 0.166956519448744 0.0272741682422084 0.0270388899377006 0.3802894927483736 0.014914102322069 5297 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +17659 C1QB LRP1 C1QB-LRP1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.2188845879772096 0.9256868304646206 0.9078204025796472 0.8875000050982297 1.0 0.0144359394371152 0.0102144012716734 0.0114023297491039 1.0 0.0028673835125448 2790 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +17698 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.2187011193739504 0.7487535481622718 0.8950084308969304 0.6198216015396206 0.1027229557481577 0.4247538686915498 0.0060376463051542 0.0324093907977038 0.3340916573616811 0.0051837888784165 2122 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +17715 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.2185957239927974 0.8818165186409654 0.6207977546603366 0.6198216015396206 1.0 0.0203874717835032 0.0157721541910882 0.0367904053216077 1.0 0.0136986301369863 1971 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +17722 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.2185595026349133 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.7029371915698084 0.2295016807597237 0.0019284597417595 0.0075118893212278 0.5159470580994124 0.0006485084306095 1542 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +17772 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.2182679500416652 0.4601010570874773 0.7346293219749174 1.0 0.0587727051993296 1.0 0.0054430428211979 0.0052660549492225 0.0390595320725118 0.0007585015380725 94924 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +17867 C1QB LRP1 C1QB-LRP1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.2177122782037995 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.8040181448318822 0.0350138403862125 0.0077235370769947 0.0192869666861484 0.6780444053496035 0.0064289888953828 1711 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +17870 VWF ITGA9 VWF-ITGA9 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.2176836717094888 0.955713094717548 0.6252253442669611 0.6198216015396206 1.0 0.0309945332907452 0.0092691214683052 0.018834701750915 1.0 0.0008705114254624 4595 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +18003 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.2170252364036738 0.6561647292424944 0.6207977546603366 1.0 0.1098969873322313 0.166956519448744 0.0139800538628587 0.0311339752060915 0.3035866910463727 0.0049084387389088 5297 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +18043 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.2168543923163411 0.6249837837987587 0.6580560501976399 1.0 0.2159908053119969 1.0 0.0011706813162621 0.001517919235211 0.0829572215789539 1.6520499579907297e-05 423716 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +18237 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.215974433163403 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.1671376945154473 0.166956519448744 0.0095591660937833 0.0397696839850026 0.3877932928591985 0.0144617032672737 1867 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +18259 MMRN2 CD93 MMRN2-CD93 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.2158732093497721 0.9845127857250529 0.4630027772793905 0.7204611100467462 1.0 0.0155837683010033 0.019774430480829 0.008499497919954 1.0 0.0004303543250609 13942 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +18262 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.2158661983242507 0.8640667164982425 0.7167436199046466 0.7204611100467462 1.0 0.0125623889131764 0.0180515027269463 0.0024252259360206 1.0 0.0003586286042174 13942 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +18335 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.2154906148847368 0.7296454584598743 0.4638256179742202 1.0 0.7029371915698084 0.0689186266365139 0.0061073050147516 0.0017092621465593 0.2082698143729217 0.0001790906409337 94924 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +18361 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.215378527258365 0.6160088550075702 0.9255624071030766 0.909150863993142 0.0149256517769723 1.0 0.012901845784218 0.0249113325451783 0.2004729297389773 0.005066711704104 5921 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +18378 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.2153107737193704 0.8924110508951895 0.4600037439857229 0.8293805866303694 1.0 0.0215025911544899 0.0136089010247132 0.0090220733330274 1.0 0.0004038364462392 9905 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +18535 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.2145971733854431 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.4344545964241579 0.0627790816848129 0.0088315014462496 0.027105600684053 0.5944645771421673 0.0051303976058144 2339 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +18620 MMRN2 CD93 MMRN2-CD93 Pericytes Pericytes Pericytes -> Pericytes 0.2142354932671397 0.9468422434493456 0.8817184225858201 1.0 0.1120119983652299 0.1281708518900828 0.0080665264242517 0.0134692246203037 0.2781788969559007 0.0003197442046362 12510 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +18681 COL4A2 CD93 COL4A2-CD93 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.2139302023031211 0.8840293712888387 0.6587114738285964 0.6198216015396206 1.0 0.0289462771086338 0.0091750960413112 0.0051974012993503 1.0 0.0004997501249375 6003 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +18695 VWF ITGA9 VWF-ITGA9 Pericytes Pericytes Pericytes -> Pericytes 0.2138560937838678 0.9275752708651288 0.9404022517663844 1.0 0.1263644540569636 0.1347191569099048 0.0064418694776369 0.0054574522200421 0.2365449266684311 0.0002398081534772 12510 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +18699 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.2138477283876784 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.4529166025129413 0.1176565474247238 0.003709979219514 0.0079323957562299 0.5448738605831591 0.000740192450037 2702 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +18718 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.2137426848372719 0.718867305289982 0.6331674633943454 0.6198216015396206 1.0 0.0176963220730796 0.0190998528510397 0.007253964150293 0.960777099038106 0.0006032402619786 11604 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +18822 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.2132282919677578 0.6160088550075702 0.9008184599638702 0.7917001487310438 0.0548063857429699 0.3180524283074206 0.0122730828670747 0.0431031132185473 0.5989873290168245 0.009833262077811 2339 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +18940 C3 LRP1 C3-LRP1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.2127734288009695 0.9487258305485792 0.7346293219749174 0.7204611100467462 0.0110943464444434 1.0 0.0166564494032315 0.0104085503383227 0.1843896452676226 0.0033832273938896 9754 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +19026 VWF SELP VWF-SELP Pericytes Pericytes Pericytes -> Pericytes 0.2123845979487516 0.9275752708651288 0.8819126042133903 1.0 0.1263644540569636 0.0741032966028748 0.0119812043970092 0.0088692682217862 0.2045647308481888 0.0009592326139088 12510 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +19088 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.2120484821400211 0.6160088550075702 0.9008184599638702 0.909150863993142 0.0149256517769723 1.0 0.0120730456711662 0.0251032534430609 0.2025506485690706 0.0043911501435568 5921 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +19106 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.2119389228614883 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.3309594876493178 0.166956519448744 0.0092063861922544 0.043908149033672 0.2463191177631888 0.0263000597728631 1673 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +19145 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.2117803828349941 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.3309594876493178 0.0350138403862125 0.0257104354725142 0.0073043224506934 0.3127055930157768 0.0021138940490679 15611 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +19229 HSPG2 LRP1 HSPG2-LRP1 Pericytes Pericytes Pericytes -> Pericytes 0.2114603432893333 0.8818165186409654 0.9078204025796472 1.0 0.1619074107723045 0.0350138403862125 0.0197010134702169 0.00574207300826 0.2458240798251397 0.0021582733812949 12510 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +19274 VWF LRP1 VWF-LRP1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.2112581539588197 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.1263644540569636 0.166956519448744 0.0118055471730455 0.0363118308453892 0.2736010183790528 0.0194174757281553 2369 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +19330 VWF LRP1 VWF-LRP1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.210956957674173 0.955713094717548 0.6207977546603366 0.6198216015396206 1.0 0.0203874717835032 0.0117558696409605 0.0249873160832064 1.0 0.0076103500761035 1971 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +19345 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.2108796061246489 0.7296454584598743 0.4638256179742202 0.8293805866303694 0.7029371915698084 0.0446401662952339 0.00998490931176 0.0031802120141342 0.358881341251848 0.0006057546693589 9905 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +19363 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.2107968924646643 0.8718210606749883 0.777821334064334 0.6198216015396206 1.0 0.0318483483218543 0.0065542586458804 0.0083424011606819 1.0 0.0004352557127312 4595 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +19451 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.2103970717447841 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.4103175828613323 0.0627790816848129 0.0082451451791995 0.0309656141208086 0.6217771421229175 0.0042753313381787 2339 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +19524 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.2101184259538683 0.724503440376099 0.6176321640000088 0.6198216015396206 1.0 0.0284069116891947 0.0109225281358197 0.0128565551289084 1.0 0.0019199122325836 3646 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +19535 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.2100620015087157 0.9356727248601746 0.4638256179742202 0.7204611100467462 1.0 0.0446401662952339 0.0061555819803093 0.0096533432025659 1.0 0.0011102886750555 2702 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +19812 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.2088768248888662 0.4604235282221027 0.944024288971064 0.7204611100467462 0.454846709299195 0.0484215930647349 0.0120416420374455 0.010130904951622 0.3432919055989266 0.0008964143426294 10040 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +19901 CD48 CD2 CD48-CD2 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.2084993713138766 0.9011089648206808 0.8960994285623033 1.0 0.4567172527116189 0.0229905310518441 0.0096894227973152 0.0177013213662428 0.8345651804758116 0.0014958863126402 4011 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +19942 VWF LRP1 VWF-LRP1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.2083425876154829 0.955713094717548 0.6207977546603366 0.6198216015396206 1.0 0.0104714078116759 0.0212382253771244 0.0137377584330794 1.0 0.0045701849836779 4595 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +20054 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.2079090190667727 0.7800321422220979 0.956444566971872 0.6198216015396206 0.0213929720256037 1.0 0.0081644904525889 0.0143797189597315 0.1661566698285014 0.0037751677852348 4768 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +20180 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.2072667512563002 0.6213271600240247 0.9694036398779844 0.6198216015396206 0.1153131738111426 0.5444650460041837 0.0033824849406182 0.017045664633019 0.339378546656411 0.002218524681087 1803 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +20531 C3 LRP1 C3-LRP1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.2057912251193088 0.7148920381722296 0.9078204025796472 0.7204611100467462 1.0 0.0064028969591119 0.0253707198685099 0.0058104575163398 1.0 0.0010457516339869 11475 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +20581 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.205554039620565 0.6605327397359113 0.657421674383923 0.8824495942126559 1.0 0.0397596998227057 0.0049508950072311 0.0057197064814039 0.4389114689314692 8.370302167908261e-05 11947 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +20764 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.2046175262836726 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.1661175896787547 0.1993723722552783 0.0064871514783359 0.0152186761229314 0.6650986901519569 0.0047281323877068 1692 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +20784 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.2045606894138491 0.718867305289982 0.956444566971872 0.7204611100467462 0.0361307801045652 1.0 0.0040938832400842 0.0219737427681353 0.1994555865957524 0.0035603026257231 2247 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +20896 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.2040879823224436 0.718867305289982 0.7167436199046466 1.0 1.0 0.0125623889131764 0.0111639796234961 0.0021604125405587 0.6959293929821214 0.0001790906409337 94924 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +20908 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.2040497851074881 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0272543760657653 1.0 0.0102190011949191 0.0170521987008739 0.2923141324447452 0.0029440628066732 5095 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +21167 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.2029430920557077 0.8818165186409654 0.6207977546603366 0.6198216015396206 1.0 0.0104714078116759 0.0196627759376413 0.0128944504896626 1.0 0.003917301414581 4595 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +21244 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.2026192190337424 0.4648000335061383 0.8604147465201248 0.7204611100467462 0.2966815529783992 0.0436001007095475 0.0185661082912834 0.0111470783532536 0.3193365064643815 0.0022908366533864 10040 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +21270 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.202531768990282 0.662063103571249 0.930308383061206 0.6198216015396206 0.585843718590581 0.1615013370958009 0.0019107579833824 0.0036287493422206 0.1370025607430954 0.0001754078231889 5701 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +21288 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.2024341695799468 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.2159908053119969 0.2295016807597237 0.0036218190712401 0.0029029605263157 0.1993871154489452 6.578947368421052e-05 30400 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +21350 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.2021627284811616 0.7324582304061453 0.62431395375366 0.6198216015396206 1.0 0.0638329144736252 0.0037731842436818 0.0035590807402887 0.929127758775668 0.0003050640634533 3278 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +21396 C3 LRP1 C3-LRP1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.2020060447893754 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0091898156146168 1.0 0.0156772209829885 0.0084707559528396 0.1500612126111305 0.0020806041457964 12977 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +21484 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.2016615530266167 0.6593525851613742 0.878254460598671 0.6198216015396206 0.4518617096918393 0.1332188634280341 0.0031128711038398 0.0096474302753902 0.3636131618402589 0.0001754078231889 5701 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +21688 A2M LRP1 A2M-LRP1 Pericytes Macrophages Pericytes -> Macrophages 0.2008302886502337 0.8937519114898692 0.8604147465201248 0.8875000050982297 0.3743986430148447 0.0436001007095475 0.0058892428042937 0.020313725490196 0.5819385067318762 0.0028235294117647 2125 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +21746 C1QB LRP1 C1QB-LRP1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.2005490205411143 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.0419710388788557 1.0 0.0039113709327565 0.0081119588197444 0.0601682509479857 0.0004596010662744 10879 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +21986 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.1996427934393962 0.8924110508951895 0.7757991160529997 0.7204611100467462 1.0 0.0091569531245039 0.0138626183053168 0.0040327042120649 1.0 0.0001921721862789 15611 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +22023 C1QB LRP1 C1QB-LRP1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.1995246276802477 0.8703788833238396 0.8604147465201248 0.6198216015396206 0.8040181448318822 0.0436001007095475 0.0038774086177467 0.0168018983466013 0.3939084647145796 0.0030618493570116 1633 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +22058 A2M LRP1 A2M-LRP1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.1994257542389314 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2100317344087863 0.166956519448744 0.0100303401095092 0.0523367477592829 0.5103344486913021 0.0172855313700384 1562 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +22085 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.1993410913259981 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.1027229557481577 0.3180524283074206 0.0045937871511193 0.02187044811927 0.3039251767486154 0.0032987747408105 2122 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +22145 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.1990451695816882 0.8640667164982425 0.6331674633943454 0.6198216015396206 1.0 0.0176963220730796 0.0103631928474165 0.0061751904243743 1.0 0.001088139281828 4595 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +22157 CD48 CD2 CD48-CD2 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.198976732733939 0.4593282471594782 0.8960994285623033 0.6198216015396206 0.0351142257737683 1.0 0.0069276164751287 0.009264046880386 0.0983073079013045 0.0007755946225439 11604 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +22223 MMRN2 CD93 MMRN2-CD93 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.1987487927569898 0.9845127857250529 0.6587114738285964 0.6198216015396206 1.0 0.0289462771086338 0.0052972441692917 0.005663834749292 1.0 0.0001665833749791 6003 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +22416 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.1980027442675475 0.4619393085577573 0.930308383061206 0.7204611100467462 0.1194227711616854 0.1615013370958009 0.0100911596988435 0.0032389020562423 0.1222839699999046 0.0008327461405419 15611 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +22491 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.1977022972357577 0.7941469661104034 0.4614667734221426 0.6198216015396206 1.0 0.12709315903692 0.0020684162171907 0.0123199565178005 0.5803801295590421 0.0006341154090044 1577 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +22812 CCN1 CAV1 CCN1-CAV1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.1963903942512374 0.9219165193585238 0.62431395375366 0.6198216015396206 0.4529166025129413 0.0649213179279442 0.0054695758288787 0.0103383250138657 0.4259525031737578 0.0016638935108153 3005 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +22828 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.1963045372613516 0.6213271600240247 0.62431395375366 0.8824495942126559 0.2247035641022029 0.0638329144736252 0.0116550361505808 0.0038942417985776 1.0 0.0008602890571231 5812 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +22844 A2M LRP1 A2M-LRP1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.1962339650769106 0.8937519114898692 0.9078204025796472 0.946515890536252 0.3743986430148447 0.0144359394371152 0.0137568905979486 0.0049665884052736 0.6093308373285219 0.0005418096442116 11074 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +22909 A2M LRP1 A2M-LRP1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.1960018907523242 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.3743986430148447 0.0501711964086628 0.0087768444329248 0.0258866371120962 0.6957797300555859 0.0094996833438885 1579 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +22921 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.1959558029836867 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.1027229557481577 0.1076178292491983 0.0206562511477765 0.0071041066235443 0.5951872334339122 0.0007889829292784 13942 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +22966 A2M LRP1 A2M-LRP1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.195775956817118 0.8937519114898692 0.6207977546603366 0.6198216015396206 1.0 0.0203874717835032 0.0080307878281307 0.0182014205986808 1.0 0.0035514967021816 1971 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +23001 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.1956509478282935 0.2542249848376565 0.942159351720962 0.2461374514707439 0.1711385759005754 1.0 0.0055593328900407 0.02484311554079 0.3660968351209197 0.0055370985603543 1806 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +23008 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.1956376773976286 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.2966815529783992 0.0350138403862125 0.0177544679483533 0.0056183673905152 0.3280611395778302 0.0009608609313945 15611 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +23115 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1951640733629973 0.9356727248601746 0.6580560501976399 0.6198216015396206 1.0 0.0606066271159369 0.0023890412687914 0.0464782964782965 1.0 0.0073710073710073 407 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +23421 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.1939669389671555 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0411214967239829 0.8672894033034337 0.0043712997605183 0.0167912895185622 0.2298194776958722 0.0027548209366391 2541 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +23548 VWF LRP1 VWF-LRP1 Pericytes Pericytes Pericytes -> Pericytes 0.1934695457369817 0.9275752708651288 0.9078204025796472 1.0 0.1263644540569636 0.0350138403862125 0.0140754217608162 0.0055292129932417 0.2258617171023467 0.001199040767386 12510 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +23602 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.193261771801215 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.1661175896787547 0.1973932010691654 0.0048801661779954 0.0187912872701303 0.3411169317219839 0.0042849491162292 1867 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +23603 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.1932520937580656 0.7324582304061453 0.7283139964676212 0.8293805866303694 0.2376713873232418 0.1449812920932466 0.0034166434430815 0.0042332453337038 0.3469893735419717 0.0001389467833819 7197 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +23628 CD48 CD2 CD48-CD2 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.1931518062699347 0.928447473463448 0.4603649459881741 0.6198216015396206 1.0 0.0112209532878862 0.0174677084064017 0.0051934920489015 1.0 0.0005515212795293 10879 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +23769 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.1925903634192254 0.7324582304061453 0.62431395375366 0.6198216015396206 1.0 0.0126805820762719 0.0141975968864289 0.0036481672986326 0.7432250138505792 0.0004308859014133 11604 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +23779 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.1925488045828595 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.2247035641022029 0.1176565474247238 0.0068724642397376 0.0161124307205067 1.0 0.003562945368171 1684 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +23855 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.1922785417102978 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.7696906278989153 0.0627790816848129 0.0046838845199028 0.0146736149204608 0.3218133547569994 0.0010970927043335 3646 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +23915 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.1920466736884439 0.7487535481622718 0.8950084308969304 0.6198216015396206 0.0637288077574987 0.4247538686915498 0.0044620435301676 0.0290747884161437 0.2997169650618016 0.0056998100063331 1579 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +23977 CCN1 CAV1 CCN1-CAV1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.1917902829261049 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.2646489893253856 0.1176565474247238 0.0033040839903207 0.0038937242327072 0.2674587375516607 0.0018323408153916 2183 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +23990 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.1917064316637812 0.8924110508951895 0.7754239189773715 0.7204611100467462 1.0 0.0147571931436988 0.0067468445668991 0.053856494706772 1.0 0.0083179297597042 1082 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +24078 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.1913169757412904 0.9356727248601746 0.6580560501976399 0.6198216015396206 0.1750253929104546 0.1973932010691654 0.0037190583695179 0.0172013507809202 0.31225492514225 0.0016884761502743 2369 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +24110 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.1911870853399288 0.9184503888425788 0.7754072541855492 0.6198216015396206 1.0 0.0238720285974944 0.0046345607341526 0.0045701849836779 1.0 0.0002176278563656 4595 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +24144 CD48 CD2 CD48-CD2 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.1910967871213773 0.9011089648206808 0.937587088419394 0.909150863993142 0.4567172527116189 0.0275738893167071 0.0050344141425699 0.0206743002544529 0.8622907048477818 0.0025445292620865 1572 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +24229 C1QB LRP1 C1QB-LRP1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.1907535410421383 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.8040181448318822 0.0416128058995347 0.0036332741264083 0.0275318696883852 1.0 0.0014164305949008 1412 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +24621 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.1893241233743262 0.8640667164982425 0.7167436199046466 0.7204611100467462 1.0 0.0326667674102811 0.003159412870154 0.0354694092827004 0.750847145385221 0.0126582278481012 474 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +24732 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.1889081601249882 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.2247035641022029 0.1449812920932466 0.0049736559249059 0.0123960695389266 1.0 0.0030234315948601 1323 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +25061 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.1876401291483083 0.7797302331085993 0.7763400818577846 0.9318789094584046 0.0200499113739789 1.0 0.0038590877518694 0.0100635239050484 0.1597763568643396 0.0008024072216649 4985 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +25162 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.1873084914365148 0.4625081978296446 0.4642836810638544 1.0 0.3558005706994493 0.0917308979735958 0.0061619599317744 0.004456201475364 0.2452054826508782 0.0001548486999161 77495 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +25188 C3 LRP1 C3-LRP1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.1872251601605566 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0691889863216023 0.166956519448744 0.0120038783286414 0.0344107672742687 0.483971541064189 0.0114455277660025 2359 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +25205 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.1871617756420703 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2966815529783992 0.166956519448744 0.0048520476756436 0.025727236501295 0.2508657037045331 0.0071727435744172 1673 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +25298 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.1868238180033739 0.7797302331085993 0.7763400818577846 0.8693461273411047 0.0699064461360958 1.0 0.0011558015921839 0.0156521739130434 0.2485061245374062 0.0034782608695652 575 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +25349 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.1866226433955449 0.4629984640915818 0.7346293219749174 0.8293805866303694 0.3309594876493178 0.0416128058995347 0.0108738157911739 0.007030680352235 0.2321587935111636 0.001110550227158 9905 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +25382 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.1864984291505435 0.6593525851613742 0.6593689120110077 1.0 0.4518617096918393 0.2390217618875283 0.0008961011036418 0.0017181319563103 0.1701213782443109 4.720142737116371e-06 423716 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +25435 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.1863087608403949 0.7324582304061453 0.7283139964676212 0.8767341187813953 1.0 0.0124087765732037 0.0072061002181195 0.011482538388368 0.5660847043880808 0.003261312678353 2453 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +25589 A2M LRP1 A2M-LRP1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.1857810317486418 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.093381536992618 0.166956519448744 0.0069315022712091 0.0319167726437756 0.3112197312313471 0.0059347181008902 2359 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +25619 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.1856964436209819 0.8818165186409654 0.9078204025796472 0.9429656149619918 1.0 0.0064028969591119 0.0084833966066561 0.0096940763834762 1.0 0.0023382696804364 2566 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +25690 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.1853940553518502 0.9067635403815892 0.956444566971872 0.9429656149619918 0.0106922602624424 1.0 0.0046435939288622 0.0156273062730627 0.1418490046277044 0.0044280442804428 2710 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +25694 A2M LRP1 A2M-LRP1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.1853869489962665 0.7741139100414175 0.6207977546603366 1.0 0.093381536992618 0.0501711964086628 0.0180303462778196 0.0238926286046705 0.6421848697028313 0.006731488406881 4011 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +25700 VWF LRP1 VWF-LRP1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.1853659843382427 0.955713094717548 0.9078204025796472 0.9429656149619918 1.0 0.0064028969591119 0.0077442461428805 0.0112617799192234 1.0 0.0019485580670303 2566 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +25731 CD48 CD2 CD48-CD2 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.1852730854273683 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0212837736082081 1.0 0.0044320631776675 0.0138422818791946 0.1468901749229839 0.0022371364653243 3576 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +25738 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1852529639459592 0.6630837220165452 0.944024288971064 0.6198216015396206 0.4103175828613323 0.0484215930647349 0.0052433952970024 0.0255064553374619 0.864301826903359 0.0036737692872887 1361 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +25796 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.1850923182165403 0.7941469661104034 0.4614667734221426 0.6198216015396206 1.0 0.0312252462757311 0.0056691185647726 0.0122252658568755 0.6658360717092334 0.0003873716831299 5163 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +25816 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.1850323122202374 0.9356727248601746 0.4638256179742202 0.2461374514707439 0.1750253929104546 0.5131068416842878 0.0041833007118629 0.0162388685175484 0.3922207775842257 0.00261917234154 1909 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +26042 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.1842538332303609 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.1836996873148393 0.0501711964086628 0.0131085080251173 0.0280687378271816 0.4762453266408233 0.0141085934159897 2339 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +26118 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.1840189489057575 0.7487535481622718 0.7754239189773715 0.946515890536252 0.1027229557481577 0.0293031867940321 0.023473968958249 0.00636739128698 0.7968818994582493 0.0011424554002987 11379 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +26334 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.1833090659339484 0.9067635403815892 0.930308383061206 0.946515890536252 0.0411127335336962 0.1615013370958009 0.007156514311347 0.0062351700500922 0.1925738648667137 0.0004394059231918 11379 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +26463 MMP2 PECAM1 MMP2-PECAM1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.1829099993770076 0.9330801352629944 0.956444566971872 0.8875000050982297 0.0088108219576754 1.0 0.0053661132129868 0.0173745519713261 0.1577087477470879 0.0050179211469534 2790 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +26488 C1QB LRP1 C1QB-LRP1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.1828329693605354 0.9256868304646206 0.6207977546603366 0.6198216015396206 1.0 0.0104714078116759 0.0100147520245259 0.0110982941834451 1.0 0.0016778523489932 3576 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +26500 A2M LRP1 A2M-LRP1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.1828053450506813 0.8937519114898692 0.6207977546603366 0.6198216015396206 1.0 0.0104714078116759 0.0103631928474165 0.0077348567283278 1.0 0.001088139281828 4595 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +26584 CCN1 CAV1 CCN1-CAV1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.182525627448008 0.9219165193585238 0.62431395375366 0.6198216015396206 0.4529166025129413 0.0638329144736252 0.0035852342065035 0.0017546782164473 0.4580734064740288 0.0001665833749791 6003 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +26686 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.1821275511658806 0.7324582304061453 0.62431395375366 0.6198216015396206 1.0 0.0641739251983978 0.0020065057856117 0.0058798097708603 0.5585535534312045 0.0006485084306095 1542 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +26738 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.1819638470575955 0.9219165193585238 0.62431395375366 0.6198216015396206 0.4529166025129413 0.0641739251983978 0.0035008308925767 0.0070015220700152 0.6651108086889299 0.0010147133434804 1971 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +26763 CD48 CD2 CD48-CD2 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.1818783579566098 0.4593282471594782 0.8960994285623033 0.6198216015396206 0.0467114894617178 1.0 0.0030374897539069 0.0411686586985391 0.4368695515919436 0.0079681274900398 753 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +26788 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.1818050784873162 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0415873844357376 1.0 0.0023961142765062 0.0110924022214344 0.0846595326641256 0.0006203473945409 4836 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +26804 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.1817518186092133 0.718867305289982 0.6331674633943454 0.6198216015396206 1.0 0.0326412663903893 0.00391444589388 0.0026464307504575 1.0 0.0003050640634533 3278 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +26812 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.1817281415761262 0.6213271600240247 0.9694036398779844 0.6198216015396206 0.1339639999453202 0.5444650460041837 0.0013227566924919 0.0032976670759515 0.0656564284049816 0.0001754078231889 5701 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +26874 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.181531015591068 0.7296454584598743 0.4638256179742202 1.0 0.293296467876477 0.0446401662952339 0.0080761634986997 0.003231071955637 0.3646207963389249 0.0001788828764366 22361 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +26937 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.1813158126831695 0.9184503888425788 0.7746834992804791 0.6198216015396206 1.0 0.0090444648829713 0.0089080675823615 0.0100534087338988 1.0 0.003770028275212 2122 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +26958 C1QB LRP1 C1QB-LRP1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.1812505086758469 0.8703788833238396 0.6207977546603366 0.909150863993142 0.8040181448318822 0.0104714078116759 0.0085725316724392 0.0053094916399256 0.5310329769179444 0.000844451950684 5921 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +27032 COL4A2 CD93 COL4A2-CD93 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.1809988050164569 0.8840293712888387 0.4630027772793905 0.7204611100467462 1.0 0.0155837683010033 0.0076510327104066 0.0032491751542103 0.8982214026530265 7.172572084349448e-05 13942 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +27049 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1809553194496984 0.6303642896310324 0.956444566971872 0.6198216015396206 0.0141923232885854 1.0 0.0066199625301817 0.0154729446308724 0.140447864539017 0.0029362416107382 4768 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +27087 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.180828976670422 0.6249837837987587 0.6580560501976399 0.8824495942126559 0.2159908053119969 0.1973932010691654 0.0022595250897386 0.0064404481552843 0.1169130077180646 0.0004281738385784 4671 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +27124 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.1807068414736047 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0637288077574987 0.3180524283074206 0.004109311144073 0.0235189130059301 0.3268332570636512 0.0044331855604813 1579 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +27203 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.1803946728909057 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.1468839381042521 1.0 0.0005779007960919 0.0542168674698795 0.8607892868012564 0.0120481927710843 83 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +27270 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.1801636300076077 0.6589792304505506 0.6207977546603366 0.8824495942126559 0.1836996873148393 0.0587195251380622 0.0087821208083823 0.0057519882235987 0.4055491808909097 0.0012044046799724 5812 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +27295 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.1800692002678263 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0291791383241764 1.0 0.0045080784763133 0.0105621792278465 0.1810601853680973 0.0006663334999167 6003 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +27329 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.1799578519278244 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0435116250366991 0.8672894033034337 0.0026347055163781 0.0101734646038443 0.1392424518098088 0.00084388185654 3555 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +27463 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.1794925207508651 0.6160088550075702 0.8950084308969304 0.909150863993142 0.0255753403203798 0.4247538686915498 0.0061414148494502 0.0135795848842344 0.1399849213018519 0.0017349063150589 5764 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +27475 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.1794341014714008 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.8713412494740926 0.040323117011325 0.0042334250395452 0.016301512780386 1.0 0.0023474178403755 1278 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +27572 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.1790921446637449 0.6605327397359113 0.7763400818577846 0.7917001487310438 1.0 0.0219439768073448 0.0037036966716667 0.0015186403508771 0.2085040093428774 6.578947368421052e-05 30400 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +27573 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.1790892513287349 0.7324582304061453 0.62431395375366 0.6198216015396206 0.2376713873232418 0.0641739251983978 0.0076318237584506 0.0038157575757575 0.3624785556046273 0.0007272727272727 6875 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +27655 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.1787419049254648 0.9184503888425788 0.7746834992804791 0.6198216015396206 0.1169448695751571 0.2295016807597237 0.0027551349918988 0.0081830327321309 0.4067837473005236 0.001002004008016 1996 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +27708 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.1785231116607509 0.6249837837987587 0.6580560501976399 0.8824495942126559 0.0411214967239829 1.0 0.0021690726613866 0.0031687313604037 0.1731772965856453 0.0001720578114246 5812 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +27751 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.1783521882510743 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0425206505665654 1.0 0.0018036376188398 0.0095393543706927 0.1514542323909614 0.0002176278563656 4595 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +27836 A2M LRP1 A2M-LRP1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.178064129924521 0.4648000335061383 0.7346293219749174 1.0 0.2100317344087863 0.0416128058995347 0.0106809964707386 0.0061435087876213 0.3644321848398539 0.0003130450337641 22361 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +28005 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1775396175092619 0.9184503888425788 0.6580560501976399 0.6198216015396206 1.0 0.0606066271159369 0.0013793136196418 0.0409500409500409 1.0 0.0024570024570024 407 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +28026 C3 LRP1 C3-LRP1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.1774419818056096 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0064915662046245 1.0 0.0101947862768906 0.0064302108736192 0.1139125299338974 0.0010041600918089 13942 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +28037 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.1774054961173235 0.724503440376099 0.6176321640000088 0.6198216015396206 1.0 0.02871400543887 0.00391444589388 0.0021862924547488 1.0 0.0003050640634533 3278 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +28062 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1773096454381607 0.6582846571368821 0.944024288971064 0.6198216015396206 0.4344545964241579 0.0484215930647349 0.0038348275483063 0.0207935341660543 0.7705142185814787 0.0022042615723732 1361 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +28173 C1QB LRP1 C1QB-LRP1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1769474033022656 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.8040181448318822 0.0144359394371152 0.0053998058035575 0.0077114140480591 0.7206217981433609 0.0018484288354898 2164 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +28295 THBS2 CD36 THBS2-CD36 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.1765104330188397 0.9197297916541942 0.8587566561291643 0.946515890536252 0.0087456089304998 1.0 0.0046256470790584 0.0041124857022455 0.0590487610814274 0.0006321112515802 11074 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +28301 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.1764939994826354 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.2159908053119969 0.1993723722552783 0.0020547341841713 0.0042735042735042 0.1867640832689588 0.0002067824648469 4836 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +28348 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1763694205305987 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0267593032157803 1.0 0.002644166203269 0.0201940850277264 0.1727939817135728 0.0018484288354898 2164 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +28379 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.176288641174509 0.9184503888425788 0.6580560501976399 0.6198216015396206 0.1169448695751571 0.1973932010691654 0.0034709310972789 0.0202617138032925 0.3626386000882915 0.0012663571127057 2369 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +28504 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.1758869479407906 0.6249837837987587 0.6580560501976399 0.8824495942126559 0.0244483651952677 1.0 0.0033367894844396 0.0036016307192243 0.1968360836923723 8.263779852904718e-05 12101 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +28627 VWF ITGA9 VWF-ITGA9 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.1754671186626006 0.955713094717548 0.2531744428854943 0.2461374514707439 1.0 0.0642389143033604 0.0076286992820535 0.0251040525739321 1.0 0.0028915662650602 2075 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +28629 C1QB LRP1 C1QB-LRP1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.175463217567915 0.9256868304646206 0.7346293219749174 0.7204611100467462 1.0 0.0416128058995347 0.0014313422370719 0.0154720279720279 0.6129842165467481 0.0013986013986013 715 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +28721 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.1752174903892156 0.9356727248601746 0.6580560501976399 0.6198216015396206 1.0 0.0362497659817488 0.0020917209409601 0.03258547008547 1.0 0.0096153846153846 312 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +28728 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.1752036980927503 0.7797302331085993 0.9130058539314824 0.6198216015396206 0.8713412494740926 0.0132636308162813 0.005671829329777 0.0088637024120895 1.0 0.000581226387678 3441 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +28829 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.1748091710773526 0.9356727248601746 0.4638256179742202 0.7204611100467462 0.1750253929104546 0.0689186266365139 0.0075658491573296 0.0038722354935655 0.4718233356284823 0.0001541188256145 12977 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +28847 C1QB LRP1 C1QB-LRP1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.1747510929639223 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0161519521398178 1.0 0.004296560807672 0.0054556376416582 0.040465710193893 0.0005020800459044 13942 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +29094 VWF ITGA9 VWF-ITGA9 Pericytes Macrophages Pericytes -> Macrophages 0.1739851141216452 0.9275752708651288 0.8794572885381431 0.8875000050982297 0.1263644540569636 0.104965956217838 0.0028884528982063 0.0124919786096256 0.2799746760935911 0.0014117647058823 2125 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +29169 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.1738023256410794 0.6593525851613742 0.878254460598671 0.6198216015396206 0.018132161410931 1.0 0.0042352382953684 0.0172799999999999 0.204655202797792 0.00192 3125 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +29246 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.1735789095436095 0.7797302331085993 0.885766439573873 0.6198216015396206 0.8713412494740926 0.0127192475389894 0.0057650173718236 0.0074542897327707 1.0 0.00056258790436 3555 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +29389 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.1730585479901764 0.4625081978296446 0.7763400818577846 0.2461374514707439 0.3558005706994493 1.0 0.0008542744479923 0.0311181434599156 0.4940559232847812 0.0031645569620253 316 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +29440 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.1729039206665543 0.9184503888425788 0.6571792026963191 0.6198216015396206 0.1169448695751571 0.1615138601457002 0.003781208488387 0.0046417174354511 0.4436682282912499 0.0001450536698578 6894 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +29454 CCN1 CAV1 CCN1-CAV1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.1728647649179898 0.9219165193585238 0.62431395375366 0.6198216015396206 0.2646489893253856 0.0649213179279442 0.0043533026970865 0.0069227522161249 0.285226439617173 0.0025327142254115 2369 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +29492 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1727568209370928 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0168149984327668 1.0 0.0033309732364803 0.0205307631370478 0.1566950762984095 0.0032347504621072 2164 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +29506 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.1726998824757691 0.4619393085577573 0.956444566971872 0.2461374514707439 0.0835287751665837 1.0 0.0029207349002634 0.0124930786267995 0.1443566697198785 0.003875968992248 1806 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +29605 C1QB LRP1 C1QB-LRP1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.1724148116193545 0.8703788833238396 0.6207977546603366 0.8693461273411047 0.8040181448318822 0.0203874717835032 0.0034116580349151 0.0196285140562249 1.0 0.0016064257028112 1245 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +29718 CD48 CD2 CD48-CD2 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.1720739944919681 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0164675938709007 1.0 0.0036765595340558 0.011860718171926 0.1258624107059284 0.001088139281828 4595 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +29725 HSPG2 LRP1 HSPG2-LRP1 Pericytes Macrophages Pericytes -> Macrophages 0.1720384739352386 0.8818165186409654 0.8604147465201248 0.8875000050982297 0.1619074107723045 0.0436001007095475 0.0054543611700884 0.0130326797385621 0.2995002643163656 0.0047058823529411 2125 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +29743 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.1719888967089641 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0048525806497539 1.0 0.0113088607730107 0.0078277529422497 0.1386702798515372 0.0016421859319405 10961 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +29835 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.171686217585125 0.6160088550075702 0.9008184599638702 0.909150863993142 0.0255753403203798 0.3180524283074206 0.0062406722597359 0.0104015519525582 0.1445463530697277 0.0017349063150589 5764 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +29947 VWF ITGA9 VWF-ITGA9 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.1713120056614856 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.1263644540569636 0.1886404570313 0.0029499390333966 0.0118874111860083 0.3108942210682606 0.001503006012024 1996 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +29973 A2M LRP1 A2M-LRP1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.1711971683680281 0.8937519114898692 0.7346293219749174 0.7204611100467462 0.3743986430148447 0.0416128058995347 0.0034160247328204 0.0096388761642998 0.5717769472446167 0.0009161704076958 2183 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +30050 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.1709689333779263 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0342558468646473 1.0 0.0028131653697629 0.0071628883639328 0.1227884764088676 0.0002901073397156 6894 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +30229 COL4A2 CD93 COL4A2-CD93 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.1703928657111431 0.8840293712888387 0.4630027772793905 0.7204611100467462 0.5544396796022323 0.0155837683010033 0.0096055019296854 0.0027510210372196 0.760508700670534 0.0001541188256145 12977 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +30462 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.1696561615727286 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.3309594876493178 0.0144359394371152 0.0164819011466421 0.0039093519027548 0.3420947949068598 0.000794087105247 16371 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +30644 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1690514988466371 0.6303642896310324 0.956444566971872 0.6198216015396206 0.0161193721503025 1.0 0.0038747751366823 0.0233595194085027 0.2120342763352175 0.0032347504621072 2164 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +30649 COL4A2 CD93 COL4A2-CD93 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.1690265265114137 0.8840293712888387 0.7779918296243433 0.6198216015396206 1.0 0.0118035014556376 0.0046345607341526 0.0105114254624592 1.0 0.0002176278563656 4595 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +30681 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.1689053353997312 0.8718210606749883 0.777821334064334 0.6198216015396206 1.0 0.0182001711419816 0.0030353524893083 0.0091324200913242 1.0 0.0005073566717402 1971 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +30698 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.1688296419450324 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.3309594876493178 0.0501711964086628 0.0078282706062741 0.0132451087950265 0.2247312010721084 0.004388370817334 3646 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +30732 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.1687347539648632 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.141548283585814 0.0518891167572028 0.0099443151879397 0.0225203078238562 0.822233590719146 0.0047028644719965 2339 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +30777 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.1685838152963393 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.1836996873148393 0.0350138403862125 0.009625163474684 0.0140146049236958 0.5999797206556864 0.0051160960251869 2541 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +31008 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.1678452861816195 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0561415215593491 1.0 0.001327274185745 0.0081466215740153 0.079659340723715 0.0019023462270133 1577 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +31089 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.1675652031999855 0.9845127857250529 0.6347970925105053 0.6198216015396206 1.0 0.0076236123034427 0.0074958010944214 0.0129783693843594 1.0 0.0013311148086522 3005 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +31224 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1671114614105245 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0316800311254893 1.0 0.0016161238016311 0.0136954697986577 0.1171875207368327 0.0002097315436241 4768 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +31270 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.1669883331466158 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0208904415011529 1.0 0.0029514436647937 0.0101668045216432 0.0642243642282616 0.0012406947890818 4836 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +31289 A2M LRP1 A2M-LRP1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.1669198837765915 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.0149044683666724 1.0 0.0041170936435033 0.0056301130618623 0.06666392333336 0.0004596010662744 10879 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +31292 C1QB LRP1 C1QB-LRP1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.1669110599761821 0.9256868304646206 0.9078204025796472 0.8875000050982297 1.0 0.0064028969591119 0.0045279344768354 0.0109439124487004 1.0 0.0020519835841313 1462 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +31421 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.1665998557818254 0.718867305289982 0.6331674633943454 0.6198216015396206 1.0 0.0049190726392343 0.0154073969773641 0.0085656899810964 1.0 0.0028355387523629 4232 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +31569 VWF ITGA9 VWF-ITGA9 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.1661672428412526 0.955713094717548 0.6252253442669611 0.6198216015396206 1.0 0.0083442542366581 0.006811659891577 0.0212847801000128 1.0 0.0049365303244005 1418 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +31824 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.1654183915304795 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.1928969878996252 0.1281708518900828 0.0019481006460342 0.0159179145867997 0.4502932264759021 0.0005546311702717 1803 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +31825 COL4A1 CD93 COL4A1-CD93 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.1654166969948976 0.7766289238087107 0.7779918296243433 0.6198216015396206 1.0 0.0118035014556376 0.0046345607341526 0.0114876418467278 1.0 0.0002176278563656 4595 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +31925 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.1650808703457997 0.7487535481622718 0.8950084308969304 0.6198216015396206 0.0338862305197021 0.4247538686915498 0.0033852108864286 0.023495177022148 0.2421996352949542 0.0035566093657379 1687 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +32028 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.1648126794393546 0.662063103571249 0.956444566971872 0.6198216015396206 0.0491302556793708 1.0 0.0010393564327965 0.027027027027027 0.3122954501928285 0.0054054054054054 370 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +32104 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.1645669484778211 0.6213271600240247 0.62431395375366 0.7917001487310438 0.2247035641022029 0.0641739251983978 0.0044854079788809 0.0113537794299876 1.0 0.0009293680297397 2152 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +32201 CD34 SELP CD34-SELP CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.1642795991756053 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0298399317533219 1.0 0.0019020279085944 0.01024 0.1238289279272291 0.00064 3125 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +32279 HSPG2 LRP1 HSPG2-LRP1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.1640700930026696 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.1619074107723045 0.0587195251380622 0.0060468802764252 0.0040232247042517 0.2836611307122145 0.0005802146794313 6894 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +32358 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.1638719312104992 0.7324582304061453 0.62431395375366 0.6198216015396206 1.0 0.009460730808256 0.0072218597154117 0.0061620040226732 0.765049966541621 0.0010970927043335 3646 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +32374 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.1638284476305397 0.6160088550075702 0.8950084308969304 1.0 0.0149256517769723 0.4247538686915498 0.0055315910368604 0.0143922395231296 0.1483621579140982 0.0027424582398404 4011 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +32540 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.1633574899888506 0.9219165193585238 0.942159351720962 0.9429656149619918 0.0086134406931133 1.0 0.0026936656709964 0.0077736777367773 0.1145556326062012 0.0018450184501845 2710 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +32640 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.163008230460253 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0151307911035231 1.0 0.0026528694815242 0.0212134698116006 0.1340068660536486 0.0022251891410769 2247 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +32684 VWF LRP1 VWF-LRP1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.1629007458500684 0.955713094717548 0.2550748532138862 0.2461374514707439 1.0 0.0267255153180908 0.0116530306380218 0.0212267250821467 1.0 0.0067469879518072 2075 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +32703 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.1628392793514826 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.454846709299195 0.0627790816848129 0.0029408588781489 0.0126361570409842 0.2537289776235961 0.0005485463521667 3646 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +32714 CD48 CD2 CD48-CD2 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1628030100473962 0.928447473463448 0.7763428264267787 0.6198216015396206 1.0 0.0050968401714881 0.0081770107868644 0.0041946308724832 1.0 0.0006291946308724 4768 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +32802 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.162560494320836 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0637288077574987 0.1076178292491983 0.0108523625963493 0.0057934667628741 0.4853808701517026 0.000308237651229 12977 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +32835 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.1624883302903204 0.7797302331085993 0.657421674383923 0.7917001487310438 0.8713412494740926 0.0069492509109592 0.0074895623908067 0.0065277777777777 1.0 0.0020833333333333 2400 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +32961 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.1621842385612301 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0131092554497256 1.0 0.0033206974684863 0.0194287371320864 0.156764672591468 0.0042530568846358 1881 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +32964 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.1621787406937926 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.0704104148800194 1.0 0.0011611401960762 0.0166209210125038 0.2638867092843674 0.000914913083257 1093 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +32996 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.1621045390858475 0.6213271600240247 0.62431395375366 1.0 0.1153131738111426 0.0641739251983978 0.0063213426808152 0.0020586432366162 0.1955611728729251 0.0002043318348998 19576 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +33022 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.1620349902862005 0.9356727248601746 0.7746834992804791 0.6198216015396206 1.0 0.0090444648829713 0.0044540337911807 0.0071080741438894 1.0 0.000942507068803 2122 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +33116 HSPG2 LRP1 HSPG2-LRP1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.1617326106297224 0.8818165186409654 0.9078204025796472 0.946515890536252 0.1619074107723045 0.0144359394371152 0.0101057128049803 0.0032207573294804 0.2818381014246811 0.0006321112515802 11074 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +33151 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.1616591570703689 0.8718210606749883 0.6593689120110077 0.6198216015396206 1.0 0.0066828239855783 0.0074958010944214 0.00942872989462 1.0 0.0013311148086522 3005 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +33215 A2M LRP1 A2M-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.1615075373392097 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.093381536992618 0.0587195251380622 0.008507399618795 0.0061047739754964 0.7849554608030381 0.0012674271229404 3945 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +33322 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.1611873837186954 0.6213271600240247 0.62431395375366 0.7917001487310438 0.1153131738111426 0.0638329144736252 0.0077585021745837 0.0017418450982338 0.4547232137602798 0.0001323758149386 30217 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +33340 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.1611132713315442 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0338862305197021 0.3180524283074206 0.0038816981607691 0.0196421835425984 0.2729598439116138 0.0041493775933609 1687 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +33453 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.1607761119255594 0.662063103571249 0.6331674633943454 0.7917001487310438 0.585843718590581 0.0518891167572028 0.0017119446785727 0.0036458333333333 0.186598666352827 0.000297619047619 3360 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +33532 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.1605374391194665 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0492631209980634 1.0 0.0009797269388631 0.013125 0.1283389485444618 0.0025 800 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +33540 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1605242272071603 0.6589792304505506 0.8604147465201248 0.6198216015396206 0.1836996873148393 0.0436001007095475 0.0060785568288231 0.0194403624785697 0.4467533782411476 0.0095518001469507 1361 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +33620 A2M LRP1 A2M-LRP1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.1602990313926594 0.8937519114898692 0.9078204025796472 0.9429656149619918 1.0 0.0064028969591119 0.0034633321619943 0.0080378020265003 1.0 0.000389711613406 2566 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +33640 VWF LRP1 VWF-LRP1 Pericytes Macrophages Pericytes -> Macrophages 0.1602448256279062 0.9275752708651288 0.8604147465201248 0.8875000050982297 0.1263644540569636 0.0436001007095475 0.0043387552349757 0.0141925133689839 0.2707333063166586 0.0032941176470588 2125 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +33674 COL4A1 CD93 COL4A1-CD93 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.1600929856016148 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.4857192596400828 0.0289462771086338 0.0037764084317562 0.0029943221849227 0.4425425136441412 0.0001450536698578 6894 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +33894 VWF ITGA9 VWF-ITGA9 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.1594913042057446 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.1263644540569636 0.1112417752963437 0.0032574319413877 0.0030461270670147 0.3292666781852414 0.0001450536698578 6894 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +33915 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.1593943390643108 0.9184503888425788 0.6580560501976399 0.6198216015396206 1.0 0.0362497659817488 0.0012076556483329 0.0277777777777777 1.0 0.0032051282051282 312 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +34067 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.1589485005853422 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.2966815529783992 0.0144359394371152 0.0123858466498702 0.002924378474131 0.3587802811313554 0.0004275853643638 16371 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +34089 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1588745803713038 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0126216524880575 1.0 0.0026845199357873 0.0105914429530201 0.0808361068000898 0.0008389261744966 4768 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +34092 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.1588668353275334 0.9097736029185508 0.8891607331132086 1.0 0.0430965463818576 0.0606680526002441 0.0076012073276413 0.0068402514254578 0.2262138070305077 0.0002554147936248 19576 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +34167 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.1586673266952337 0.9184503888425788 0.8818326005152037 0.9429656149619918 1.0 0.0042655619249233 0.0048978913144952 0.0051961548454143 1.0 0.0007794232268121 2566 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +34201 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.1585795275139156 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0186793449598515 1.0 0.0018415767489312 0.0040315191497159 0.0555206899814028 6.108362348054486e-05 16371 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +34228 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.158484532666239 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.7696906278989153 0.0118035014556376 0.0078117212129036 0.0037056187521544 0.375001371942095 0.0002585315408479 11604 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +34274 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.158341454924637 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.2545335314555431 0.1281708518900828 0.0016424249195809 0.0105644743656136 0.2988526683048708 0.0005178663904712 1931 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +34347 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.1581669100032896 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0683610513379333 0.166956519448744 0.0076998912775917 0.037114098733817 0.2082053618265486 0.0249679897567221 1562 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +34566 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.1575325309316942 0.8818165186409654 0.2550748532138862 0.2461374514707439 1.0 0.0267255153180908 0.0103293076574702 0.0180254350736278 1.0 0.0053012048192771 2075 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +34607 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.1574181122324719 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.1153131738111426 0.1176565474247238 0.0039987687684191 0.0038833437305053 0.2667457040012181 0.0003119151590767 6412 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +34609 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.1574092316846372 0.7324582304061453 0.252518874138558 0.2461374514707439 1.0 0.0322196586137726 0.0103706327309842 0.0057545201668984 1.0 0.0006954102920723 5752 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +34719 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.157087438578606 0.6342079770588467 0.6580560501976399 1.0 0.0673400749834054 1.0 0.0005346534306925 0.0011139536859594 0.0605605183723705 4.720142737116371e-06 423716 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +34747 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.1569820335017124 0.7741139100414175 0.6207977546603366 0.8693461273411047 0.1671376945154473 0.0501711964086628 0.0042719086660407 0.019875478927203 0.5342121227570676 0.0067049808429118 1044 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +35024 VWF LRP1 VWF-LRP1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.1562851284191308 0.9275752708651288 0.9078204025796472 0.946515890536252 0.1263644540569636 0.0144359394371152 0.0100220866661019 0.0031379808560592 0.2771929043562734 0.0006321112515802 11074 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +35045 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.1562051032454959 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0342558468646473 0.12709315903692 0.0159209374851064 0.008063717125904 0.3798731905829168 0.00084765354088 12977 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +35134 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.1559606713670678 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0172764782878141 1.0 0.0023686467167059 0.0280732860520094 0.1773407706079335 0.0023640661938534 1692 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +35234 C1QB LRP1 C1QB-LRP1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.155701361225795 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0111808254589153 1.0 0.0031053221346351 0.0042864298374046 0.0317934289188145 0.0003852970640363 12977 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +35240 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.1556749724250696 0.7148920381722296 0.7346293219749174 0.8767341187813953 1.0 0.0032275631628407 0.0095776637864215 0.0109050142682429 1.0 0.003261312678353 2453 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +35303 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.1555232304816297 0.7487535481622718 0.7754239189773715 0.8875000050982297 0.1027229557481577 0.0521257226458961 0.0051286678845022 0.0130121329347635 0.5441980413915297 0.0015473887814313 2585 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +35406 MMP2 PECAM1 MMP2-PECAM1 Pericytes Pericytes Pericytes -> Pericytes 0.1551842293173544 0.9067635403815892 0.930308383061206 1.0 0.0216588811659259 0.1615013370958009 0.0047331603643996 0.004134692246203 0.1277003930107677 0.0002398081534772 12510 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +35421 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.1551405292079768 0.7941469661104034 0.8891607331132086 0.7917001487310438 0.0526353932596327 0.0606680526002441 0.0078103604255049 0.0307060755336618 1.0 0.0076628352490421 1305 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +35519 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.1548929666195978 0.6249837837987587 0.6580560501976399 1.0 0.0411214967239829 0.1973932010691654 0.0041367212027671 0.0095179661443584 0.172778977870139 0.0007551444213705 5297 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +35568 HSPG2 LRP1 HSPG2-LRP1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.1547388534431618 0.8818165186409654 0.7346293219749174 0.7204611100467462 0.1619074107723045 0.0416128058995347 0.0043656040595108 0.0113121596172443 0.3735367271974308 0.0022904260192395 2183 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +35707 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.154374849895146 0.724503440376099 0.7373999388878224 0.8293805866303694 1.0 0.0056518532344078 0.0054046727879909 0.0007613999663469 0.6308886175174325 0.0001009591115598 9905 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +35731 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.1543146315648248 0.9184503888425788 0.8818120773736414 0.8875000050982297 1.0 0.0054043611446182 0.0034761306712463 0.0058027079303675 1.0 0.0003868471953578 2585 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +35759 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.1542428512345711 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0492631209980634 0.166956519448744 0.0042766277449398 0.0196616675593644 0.1102994481334604 0.0101767541510444 1867 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +35795 CCN1 CAV1 CCN1-CAV1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.154172612235977 0.9219165193585238 0.62431395375366 0.6198216015396206 0.4529166025129413 0.0126805820762719 0.0065542586458804 0.0050852375770765 1.0 0.0004352557127312 4595 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +35880 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.1538824447173697 0.7324582304061453 0.943345641464811 0.7204611100467462 1.0 0.0034806998160403 0.007663052563988 0.0014785766158315 0.5473804463644801 0.0001742919389978 11475 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +36129 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.1532764515903409 0.9184503888425788 0.4638256179742202 0.2461374514707439 0.1169448695751571 0.5131068416842878 0.0020609778716336 0.0104766893661602 0.2380011709657611 0.001047668936616 1909 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +36159 COL4A2 CD93 COL4A2-CD93 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.153198423438679 0.8840293712888387 0.6587114738285964 0.6198216015396206 1.0 0.0042738820064046 0.0083805603964718 0.0127787021630615 1.0 0.0016638935108153 3005 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +36221 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.1530279905241604 0.7941469661104034 0.663300745568453 1.0 0.0526353932596327 0.0373075519081129 0.012414770530763 0.0469133529700543 0.8852028322511033 0.0154639175257731 1552 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +36324 CD34 SELP CD34-SELP T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1527718272942508 0.633566764858408 0.8819126042133903 0.6198216015396206 0.015517736049123 1.0 0.002365617342597 0.0103817114093959 0.1255425970581432 0.0004194630872483 4768 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +36575 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.1521540701198404 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.1339639999453202 0.1176565474247238 0.002806660612059 0.0023758796565304 0.1631984535968228 0.0003873716831299 5163 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +36659 HSPG2 LRP1 HSPG2-LRP1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.1519341312874893 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.1619074107723045 0.0501711964086628 0.0044628749317968 0.0176711702202519 0.2998286665216438 0.0056998100063331 1579 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +36745 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.1516927121762308 0.7324582304061453 0.8818704453527788 0.7204611100467462 1.0 0.0051192928876727 0.005114208238748 0.0029581673306772 0.5573031045321128 9.9601593625498e-05 10040 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +36782 A2M LRP1 A2M-LRP1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.1516071462683414 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2100317344087863 0.0501711964086628 0.0064430998406974 0.0242596671561429 0.6520501134252048 0.0073421439060205 1362 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +36842 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.1514744642695578 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.1836996873148393 0.0416128058995347 0.0052661529377927 0.0152414885193983 0.5032863689860234 0.0041567695961995 1684 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +36884 COL4A1 CD93 COL4A1-CD93 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.1513619346355837 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.4857192596400828 0.0155837683010033 0.0061324426680859 0.0026310285229912 0.6199562589323593 7.70594128072744e-05 12977 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +36907 CD34 SELP CD34-SELP CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.1513008621060181 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.1173076386135379 0.0741032966028748 0.0030299405039158 0.0028505540964704 0.1433174014674412 6.405739542630197e-05 15611 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +37019 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1509942505542343 0.6213271600240247 0.942159351720962 0.6198216015396206 0.013905026986541 1.0 0.0023489676494432 0.0055998322147651 0.0825210850735544 0.0006291946308724 4768 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +37290 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.1503410263697923 0.2534163760166434 0.8818326005152037 0.2461374514707439 0.2100740470724093 0.8672894033034337 0.0011521957320166 0.0119527649769585 0.1635954285100869 0.0005760368663594 1736 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +37295 VWF ITGA9 VWF-ITGA9 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1503226397349695 0.955713094717548 0.6252253442669611 0.6198216015396206 1.0 0.0112932915661816 0.0027586272392837 0.0317176680813044 1.0 0.0098280098280098 407 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +37342 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.1501953870416736 0.6160088550075702 0.9008184599638702 1.0 0.0149256517769723 0.3180524283074206 0.0043579475150123 0.0121484100541692 0.1688217659186803 0.0014958863126402 4011 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +37415 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.1499665023171216 0.662063103571249 0.930308383061206 0.6198216015396206 0.0967042147306326 0.1615013370958009 0.0019078694587023 0.0081168831168831 0.3064509745346203 0.0003935458480913 2541 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +37438 COL4A1 CD93 COL4A1-CD93 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.1499266281635431 0.7766289238087107 0.6587114738285964 0.6198216015396206 1.0 0.0042738820064046 0.0083805603964718 0.0151652008557166 1.0 0.0016638935108153 3005 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +37489 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.1498085143840655 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2966815529783992 0.0501711964086628 0.0042460962927715 0.0098395501919912 0.2644669350756642 0.0010970927043335 3646 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +37544 VWF LRP1 VWF-LRP1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.1496724393207932 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.1263644540569636 0.0587195251380622 0.0042449873748409 0.0026884379038426 0.2795888780035381 0.0002901073397156 6894 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +37631 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.1494420589801125 0.6561647292424944 0.6207977546603366 0.8824495942126559 0.112230917768503 0.166956519448744 0.0016537334913499 0.0128452151573538 0.1252534037040279 0.0002140869192892 4671 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +37704 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.1492606341885574 0.7487535481622718 0.7754239189773715 1.0 0.1027229557481577 0.0178869147172998 0.0103654925822736 0.003507174412566 0.599556513750625 0.0002347601533766 12779 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +37757 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.1491492344343939 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0208904415011529 1.0 0.001530074701953 0.0086848635235732 0.0517818236778051 0.0004135649296939 4836 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +37810 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.1490233528284982 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0215813276111062 1.0 0.001203592705006 0.0154649330181245 0.1831585071226008 0.0005910165484633 1692 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +37815 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.1490099944853968 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.1098969873322313 0.0501711964086628 0.0061564102213776 0.0161215619210488 0.4333145303087787 0.0034202650705429 2339 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +37843 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.1489332037785637 0.4648000335061383 0.7346293219749174 0.2461374514707439 0.0357762282281787 1.0 0.0036294529847072 0.0121951219512195 0.1443975752998754 0.0008198401311744 4879 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +37879 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.1488319449196213 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0117842887908422 1.0 0.002014945934635 0.0055738806425997 0.0332331882766859 0.000122167246961 16371 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +38127 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1481490519999938 0.7800321422220979 0.956444566971872 0.6198216015396206 0.0113788029360913 1.0 0.0020093477689422 0.008635628465804 0.0997840967387725 0.0018484288354898 2164 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +38182 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.1480017275102972 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0338862305197021 0.1076178292491983 0.0116237814438044 0.0058950174287471 0.4938888589921296 0.0006151322534344 9754 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +38188 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.147985699044949 0.724503440376099 0.6176321640000088 0.6198216015396206 1.0 0.0063011237754475 0.0060098271130705 0.0032998678616569 0.6658625618341459 8.617718028266115e-05 11604 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +38222 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.1479081345006055 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0151307911035231 1.0 0.0015117497929773 0.0182465509568313 0.1087915408008614 0.0008900756564307 2247 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +38238 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.1478733547348493 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.1836996873148393 0.0144359394371152 0.0106327832373647 0.0088444444444444 0.7739488497198825 0.0032 3125 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +38617 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.1469076253036593 0.9356727248601746 0.8818326005152037 0.9429656149619918 1.0 0.0042655619249233 0.0030288748798048 0.0030202650038971 0.7648466605807902 0.000389711613406 2566 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +38817 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.1463960222707591 0.8840293712888387 0.7779918296243433 0.6198216015396206 1.0 0.0053794918117879 0.0042926366569628 0.0104008117706747 1.0 0.0010147133434804 1971 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +38887 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.1462423532797373 0.7487535481622718 0.7757991160529997 1.0 0.1027229557481577 0.0279580382843415 0.0058637530434285 0.0041047457120702 0.5756027136392828 7.825338445887784e-05 12779 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +38904 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.1461950930611579 0.9184503888425788 0.6571792026963191 0.6198216015396206 1.0 0.0069630688870869 0.0037479005472107 0.0089850249584026 1.0 0.000332778702163 3005 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +38919 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.1461452284523491 0.9184503888425788 0.4641352222874551 0.7204611100467462 0.1169448695751571 0.1370986982961073 0.0019787014923348 0.0119102153000458 0.3836853234192235 0.0004580852038479 2183 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +38936 CXCL12 CXCR4 CXCL12-CXCR4 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.1461088622444319 0.6160088550075702 0.9008184599638702 0.9318789094584046 0.0052742025956585 1.0 0.0035671121865465 0.0112792924227227 0.0910092391332731 0.0012036108324974 4985 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +39030 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.1458575762464401 0.9219165193585238 0.62431395375366 0.6198216015396206 0.4529166025129413 0.009460730808256 0.0062989549947558 0.0084982720703738 1.0 0.001885014137606 2122 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39075 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.1457436197309478 0.7324582304061453 0.252518874138558 0.2461374514707439 0.2376713873232418 0.0322196586137726 0.0274906313944799 0.0055434217368694 0.9700774560311236 0.0010140405616224 12820 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39092 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.1457004260521826 0.7941469661104034 0.663300745568453 0.8824495942126559 0.0083898580598364 1.0 0.002453051879725 0.0064603611575394 0.1107455349408455 0.0003441156228492 5812 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +39152 VWF SELP VWF-SELP CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.1455253648760264 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0071496754272206 1.0 0.002920861263638 0.0027598691699846 0.0155186721184654 0.0005497526113249 16371 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +39229 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.1453319535283315 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.1932385901170197 0.0284069116891947 0.0056233297361807 0.0087288014821148 0.7230448666107193 0.0017101325352714 2339 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +39265 CD48 CD2 CD48-CD2 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.145252464390257 0.6659645551150886 0.8960994285623033 0.7917001487310438 0.0081474500750471 1.0 0.0024397704816813 0.0130434782608695 0.1384135087021319 0.0017391304347826 2300 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +39357 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.1450259456589289 0.7324582304061453 0.62431395375366 0.6198216015396206 0.2376713873232418 0.0649213179279442 0.0021274298464469 0.0050149381135296 0.206622005001242 0.0019206145966709 1562 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39366 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.1449988157935866 0.8924110508951895 0.4600037439857229 0.2461374514707439 1.0 0.017738069381683 0.0051853163654921 0.0044016310532304 1.0 0.000173852573018 5752 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +39371 CCN1 CAV1 CCN1-CAV1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.1449860094419017 0.8619922139338987 0.942159351720962 0.8875000050982297 0.0054092055025683 1.0 0.0023824532281755 0.0073835125448028 0.1088060219455863 0.0014336917562724 2790 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39408 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.1448703330863105 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0411214967239829 0.1993723722552783 0.0033008044249663 0.0085333333333333 0.3729305214714568 0.00064 3125 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +39420 A2M LRP1 A2M-LRP1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.1448266292321317 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.3743986430148447 0.0203874717835032 0.0035152611137673 0.0111681696726786 0.6622058414846576 0.001002004008016 1996 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39422 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.1448241431542635 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.1671376945154473 0.0350138403862125 0.0036195848838167 0.0088740987243483 0.5181659969674746 0.0016638935108153 1803 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39512 CCN1 CAV1 CCN1-CAV1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.1446166340156098 0.9219165193585238 0.62431395375366 0.6198216015396206 0.2646489893253856 0.0641739251983978 0.0015097892359054 0.0025718102872411 0.2443095662394666 0.000501002004008 1996 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39524 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.1445658902621617 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.1132020978253244 0.0761275033764692 0.0047206674749242 0.0049460431654676 0.4763518791814736 0.0008992805755395 3336 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +39533 A2M LRP1 A2M-LRP1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.1445471049107206 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.3743986430148447 0.0104714078116759 0.0067652232183611 0.0053698685134999 0.7370615474425536 0.0012044564890093 3321 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39552 MMRN2 CD93 MMRN2-CD93 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.1445057482477965 0.9845127857250529 0.6587114738285964 0.6198216015396206 1.0 0.0042738820064046 0.0053003317842909 0.0091514143094841 1.0 0.0006655574043261 3005 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +39569 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.1444575315862569 0.8913986641324685 0.956444566971872 0.8875000050982297 0.0054950348959687 1.0 0.0021855851898501 0.006339605734767 0.0732537109984119 0.0017921146953405 2790 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +39576 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.1444451722229773 0.4619393085577573 0.956444566971872 0.7204611100467462 0.0308750930304183 1.0 0.0009241655594069 0.0070371606586559 0.0813139104710466 0.0004450378282153 2247 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +39707 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.1441287003482176 0.7741139100414175 0.6207977546603366 1.0 0.1671376945154473 0.0203874717835032 0.005474052830955 0.0024732665849339 0.1466499550144485 0.0002043318348998 19576 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39804 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.1438811467869237 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0616816618657801 0.0501711964086628 0.0092297367345142 0.0180525865754595 0.5194281789345501 0.006412997007268 2339 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39924 C1QB LRP1 C1QB-LRP1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.1435831121176766 0.9256868304646206 0.6207977546603366 0.6198216015396206 1.0 0.0203874717835032 0.0012066242103486 0.0092592592592592 0.5243556900489297 0.0016835016835016 594 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +39979 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.1434436248088724 0.9184503888425788 0.7754072541855492 0.6198216015396206 0.1169448695751571 0.0826982152707935 0.0020405897067484 0.0120240480961923 0.4462921073546498 0.000501002004008 1996 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +39982 C3 LRP1 C3-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.1434394013588457 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0691889863216023 0.0587195251380622 0.0069018836937671 0.0035678073510773 0.8610638784128999 0.0007604562737642 3945 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +40032 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.1433054127964661 0.8840293712888387 0.4630027772793905 0.7204611100467462 1.0 0.0058437228618857 0.0050260116405429 0.0035529237601776 1.0 0.000740192450037 2702 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +40065 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.1432381736734303 0.9356727248601746 0.7746834992804791 0.6198216015396206 1.0 0.0046263543438723 0.0041552462648002 0.0022850924918389 0.8038525244236794 0.0002176278563656 4595 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +40185 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1428872636535175 0.7745997874735252 0.878254460598671 0.6198216015396206 0.016822895653248 1.0 0.0011997534840443 0.0054530201342281 0.0645826933698445 0.0002097315436241 4768 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +40314 COL4A2 CD93 COL4A2-CD93 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.1425355348304675 0.9188764516910942 0.8817184225858201 0.8875000050982297 0.0090193130488293 1.0 0.0012930227814632 0.0074910394265232 0.064098300462987 0.0007168458781362 2790 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +40505 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.1420749905419584 0.9219165193585238 0.8818704453527788 0.8875000050982297 0.4529166025129413 0.0051192928876727 0.0049159911398577 0.0056221792392005 1.0 0.0007736943907156 2585 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +40516 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.1420566999204317 0.8924110508951895 0.7754239189773715 0.7204611100467462 1.0 0.0015914585039484 0.0103575530141567 0.0021944939591998 1.0 0.0001742919389978 11475 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +40520 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.1420466088174564 0.8924110508951895 0.6632137581773894 0.6198216015396206 1.0 0.0080072638027924 0.0027964933467362 0.0043199478345921 1.0 0.0005977286312014 1673 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +40659 A2M LRP1 A2M-LRP1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.1416840038143885 0.8937519114898692 0.2550748532138862 0.2461374514707439 1.0 0.0267255153180908 0.0053943049939729 0.0127108433734939 1.0 0.0014457831325301 2075 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +40676 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.1416167436247934 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0117842887908422 1.0 0.0014645464749293 0.0055586097367295 0.0351140985915978 6.108362348054486e-05 16371 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +40699 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.1415400588129659 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0291791383241764 0.12709315903692 0.0103451224273181 0.005809783388323 0.2736927545769383 0.0004303543250609 13942 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +40838 CXCL12 ITGA4 CXCL12-ITGA4 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.141216011315623 0.6160088550075702 0.9255624071030766 0.9318789094584046 0.0052742025956585 1.0 0.0028300382915272 0.010677487006474 0.08592663995616 0.0008024072216649 4985 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +40893 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.1410631757448041 0.7783550150988336 0.7779918296243433 0.8693461273411047 0.1928969878996252 0.0627790816848129 0.0012359258807835 0.0142720306513409 0.3130060375714515 0.0009578544061302 1044 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +40970 VWF ITGA9 VWF-ITGA9 Pericytes Mast Cells Pericytes -> Mast Cells 0.140856515698049 0.9275752708651288 0.863034163938375 0.8567148457705164 0.1263644540569636 0.0627102121186242 0.0014370830575934 0.0488888888888888 0.392716886826134 0.0222222222222222 225 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +40980 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.1408305173732245 0.4601010570874773 0.7346293219749174 0.8293805866303694 0.0170183763647696 1.0 0.0016352502843076 0.005358135334167 0.0397425133143842 0.0002778935667639 7197 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +41029 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.1407374833529739 0.7158082793127664 0.9404022517663844 0.7204611100467462 0.0071496754272206 1.0 0.0022410361957229 0.0024544510525818 0.0274063813090584 0.0001832508704416 16371 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +41142 CD48 CD2 CD48-CD2 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.140461668389569 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0076331962782219 1.0 0.0023464961118735 0.0111412225233363 0.1182273370526089 0.000903342366757 3321 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +41145 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.140450734857005 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0070532058552773 1.0 0.0030685203832841 0.0031559273217513 0.0308593062214334 0.0005515212795293 10879 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +41179 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.1403876986353345 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.1671376945154473 0.0416128058995347 0.003122709200612 0.0054845082137658 0.3253403519405877 0.0001559575795383 6412 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +41239 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.1402448984519661 0.7766289238087107 0.4630027772793905 0.7204611100467462 1.0 0.0058437228618857 0.0050260116405429 0.0043089774770011 1.0 0.000740192450037 2702 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +41255 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.1402067277778043 0.7797302331085993 0.7763400818577846 1.0 0.1132020978253244 0.0293997450046583 0.0037706597645446 0.0061497548408543 0.3791581503835078 0.00049862877088 4011 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +41256 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.140202629229106 0.6213271600240247 0.62431395375366 0.7917001487310438 0.1153131738111426 0.0649213179279442 0.0033035824478224 0.0075879307266559 0.3126326636658526 0.0021424745581146 1867 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +41322 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.1400346262563329 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0075637985935472 1.0 0.0028108913072367 0.0074024114042099 0.072382300671226 0.0020983213429256 3336 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +41394 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.1398772052016611 0.7158082793127664 0.7346293219749174 1.0 0.0071496754272206 1.0 0.0019921753740977 0.0017524785378541 0.0134546725908401 0.0002949728203615 94924 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +41581 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.1394252635187647 0.4630253981438691 0.4630027772793905 1.0 0.7696906278989153 0.0155837683010033 0.0028567348009307 0.0014011208967173 0.3873342363538463 2.1069487168682315e-05 94924 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +41627 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.1393296346132336 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.3309594876493178 0.0104714078116759 0.0118490591242787 0.0038707916810295 0.3235477515093805 0.0006894174422612 11604 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +41638 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.1393076309982499 0.7941469661104034 0.663300745568453 0.9592803095773328 0.0526353932596327 0.0265498740402422 0.0103502663342763 0.0377130116260553 0.9580986656498378 0.0107023411371237 1495 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +41786 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.1389403600020827 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0967042147306326 0.0518891167572028 0.0043198531478676 0.0083368961094484 0.426693585063815 0.0017101325352714 2339 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +41933 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.1385887945062797 0.8640667164982425 0.6331674633943454 0.6198216015396206 1.0 0.0032187363284526 0.0064915541694841 0.0058652246256239 1.0 0.0009983361064891 3005 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +42009 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.1384004254876961 0.6303642896310324 0.956444566971872 0.6198216015396206 0.0104129581710415 1.0 0.0018060487494487 0.0151447990543735 0.1374692882837094 0.00177304964539 1692 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +42030 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.1383399497031808 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.4529166025129413 0.0124087765732037 0.0025781941469729 0.0215189873417721 1.0 0.0063291139240506 474 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +42033 C3 LRP1 C3-LRP1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.1383360574833196 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0334108479684367 0.166956519448744 0.0040448030204588 0.0115208333333333 0.1620351972461359 0.00375 2400 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +42070 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.1382634289383501 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.2545335314555431 0.0627790816848129 0.0019581010194678 0.0137298091042584 0.3011143438045086 0.0014684287812041 1362 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +42085 C3 LRP1 C3-LRP1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.1382108147474461 0.6319926036888139 0.6207977546603366 1.0 0.0691889863216023 0.0501711964086628 0.0051179682584837 0.0097107953128895 0.2794093081507331 0.0012465719272001 4011 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +42245 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.1377878133762852 0.2542249848376565 0.7283139964676212 0.2461374514707439 0.1711385759005754 0.1176565474247238 0.0074573678131375 0.0043207104724841 0.2967882929637693 0.0002245172878311 13362 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +42249 C3 LRP1 C3-LRP1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.1377778891728379 0.7148920381722296 0.7346293219749174 0.8767341187813953 0.0029337538459309 1.0 0.0050637761979277 0.0114897959183673 0.2035441367646328 0.0044897959183673 2450 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +42345 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.1375236005692273 0.7783550150988336 0.944024288971064 0.6198216015396206 0.1928969878996252 0.0484215930647349 0.0015902610476367 0.0153684210526315 0.5694840926816115 0.0042105263157894 475 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +42359 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.1374912850845182 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0172764782878141 1.0 0.0011353476363567 0.0273345153664302 0.1629767757640478 0.0005910165484633 1692 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +42387 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.13742375241334 0.9470274865242416 0.8818326005152037 0.9429656149619918 0.0061455194924501 0.8672894033034337 0.0016047232835258 0.0041692562668324 0.0570638899748843 0.0009322560596643 3218 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +42497 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1371675191280168 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.1661175896787547 0.0606066271159369 0.0020317831327684 0.0143880208333333 0.3449714038700346 0.0015625 1280 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +42511 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1371187754795107 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.293296467876477 0.0606066271159369 0.0012563468877689 0.0213707637835103 0.5123916951171458 0.0015174506828528 659 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +42557 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.1370205640351175 0.2451358214448441 0.4614667734221426 0.2461374514707439 0.1327555461750915 0.12709315903692 0.0140868640168222 0.0153915224626436 0.7250783546251384 0.0024595203935232 4879 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +42621 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.1368634472521833 0.6213271600240247 0.9694036398779844 0.6198216015396206 0.013905026986541 0.5444650460041837 0.0023253541716472 0.0054477262072198 0.1084640254629287 0.00084388185654 3555 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +42629 VWF SELP VWF-SELP Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.1368489330895585 0.955713094717548 0.7760344326192508 0.6198216015396206 1.0 0.0032078747392388 0.0044540337911807 0.0069402793248222 1.0 0.000942507068803 2122 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +42644 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.1368211421788089 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.0198024073017111 1.0 0.000920843795539 0.0286486486486486 0.2451368340737591 0.0054054054054054 370 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +43033 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.1358616560029628 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.1882781599600688 0.0518891167572028 0.0018983234471782 0.0095392653578214 0.4882324645728542 0.0006333122229259 1579 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +43099 VWF ITGA9 VWF-ITGA9 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.1356918229204694 0.955713094717548 0.7831795333113832 0.7827641335561659 1.0 0.0055509879377996 0.0019192384189863 0.01407475772958 1.0 0.0050761421319796 394 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +43195 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.1354438208418878 0.7487535481622718 0.9255624071030766 0.6198216015396206 0.0131092554497256 1.0 0.0010963810765609 0.0169880624426079 0.1367107376645522 0.0005316321105794 1881 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +43250 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.1353085411683871 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.1836996873148393 0.0203874717835032 0.005059362241922 0.0116364622057001 0.3635127128365581 0.0032527881040892 2152 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +43263 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.1352797799764441 0.9197297916541942 0.8587566561291643 0.9429656149619918 0.0055862851962672 1.0 0.0014731407874636 0.0059655596555965 0.0856559590293489 0.0007380073800738 2710 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +43277 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.1352284254766676 0.7766289238087107 0.7779918296243433 0.6198216015396206 1.0 0.0053794918117879 0.0030353524893083 0.0140247879973907 1.0 0.0005073566717402 1971 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +43282 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.135221021990757 0.4629984640915818 0.7346293219749174 1.0 0.0683610513379333 0.0416128058995347 0.0063180181027188 0.0033788987771367 0.1115739905949553 0.0003577657528733 22361 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +43353 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.135074325329327 0.8640667164982425 0.6331674633943454 0.6198216015396206 1.0 0.0049190726392343 0.0036409853642158 0.005641748942172 1.0 0.001410437235543 1418 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +43440 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.1348798021963789 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.1836996873148393 0.0104714078116759 0.0096646144616034 0.0079951690821256 0.6682919652165411 0.0056521739130434 2300 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +43503 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.1347250971171954 0.6605327397359113 0.657421674383923 1.0 0.1468839381042521 0.0397596998227057 0.0023579427823868 0.0099871134020618 0.7663782447466008 0.0006443298969072 1552 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +43561 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.1345972134811939 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.3309594876493178 0.0064028969591119 0.0092656065097459 0.0027051561365287 0.3201056701342736 0.0004357298474945 11475 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +43571 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.1345735081150016 0.8924110508951895 0.7757991160529997 0.7204611100467462 1.0 0.0012252690191386 0.0097184547269779 0.0010972469795999 0.8804001380551378 0.0001742919389978 11475 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +43574 VWF SELP VWF-SELP Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.1345692900264394 0.955713094717548 0.941479368642921 0.8875000050982297 1.0 0.0021392900294222 0.0034761306712463 0.0065412343942324 1.0 0.0003868471953578 2585 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +43585 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.1345492825745035 0.4629984640915818 0.7346293219749174 0.2461374514707439 0.0201301851612071 1.0 0.0035205746184941 0.0092630548154221 0.0905760545006465 0.0012297601967616 4879 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +43626 C3 LRP1 C3-LRP1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.1344284247752292 0.7148920381722296 0.7346293219749174 0.8293805866303694 0.005043231651446 1.0 0.0026864122341435 0.004036404057246 0.0715057417296719 0.0004168403501458 7197 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +43674 VWF ITGA9 VWF-ITGA9 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.134297238629269 0.955713094717548 0.950463483645931 0.9429656149619918 1.0 0.0019776346124415 0.0034633321619943 0.0027988379508254 1.0 0.000389711613406 2566 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +43684 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.1342692823885506 0.8533682807143209 0.8817184225858201 0.6198216015396206 0.0706049302656684 0.1281708518900828 0.0013883512250457 0.0097060454797559 0.2287027196190626 0.0005546311702717 1803 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +43892 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.133728625388757 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.1098969873322313 0.0350138403862125 0.0040256865671229 0.0077889282434736 0.4548019910477229 0.0011806375442739 2541 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +44022 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.1333818679516966 0.9845127857250529 0.6347970925105053 0.6198216015396206 1.0 0.003263637675389 0.0044540337911807 0.0113100848256361 1.0 0.000942507068803 2122 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +44040 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.1333433270173063 0.7487535481622718 0.7757991160529997 0.8875000050982297 0.1027229557481577 0.0491709261488903 0.0021587041622914 0.008545806224723 0.385650652512756 0.0003868471953578 2585 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +44077 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1332720146422163 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0435116250366991 0.1993723722552783 0.0018907732664566 0.0036703020134228 0.1604024582605675 0.0002097315436241 4768 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +44088 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1332464421452912 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.1932385901170197 0.088850508457521 0.0009810134736877 0.0077455302473671 0.151272567941838 0.0007347538574577 1361 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +44094 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.1332282450421254 0.8640667164982425 0.7167436199046466 0.7204611100467462 0.1882781599600688 0.0125623889131764 0.0052988643586171 0.0009969561531941 0.4628706679744285 7.70594128072744e-05 12977 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +44126 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.1331496244646665 0.6589792304505506 0.6207977546603366 0.8824495942126559 0.0561415215593491 0.166956519448744 0.0016467875805168 0.0073800518566093 0.0414011499544774 0.0006422607578676 4671 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +44326 CD34 SELP CD34-SELP Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.1326495920982308 0.8963354148873306 0.8819126042133903 0.8875000050982297 0.0038492365148421 1.0 0.0020174052482598 0.0064516129032258 0.0780172176960869 0.0014336917562724 2790 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +44349 COL4A1 CD93 COL4A1-CD93 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.1325992452521541 0.9102252263107924 0.8817184225858201 0.8875000050982297 0.0042860632265532 1.0 0.0017804800879175 0.0079621095750128 0.060768484786695 0.0014336917562724 2790 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +44438 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.1323726968624198 0.8924110508951895 0.7757991160529997 0.7204611100467462 1.0 0.0044430418127202 0.0024276303095876 0.0155856158628801 0.5826076809508433 0.0018484288354898 1082 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +44506 VWF SELP VWF-SELP Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.1322099176117849 0.955713094717548 0.6572093097629401 0.6198216015396206 1.0 0.002113171886167 0.0064915541694841 0.0059597640296475 1.0 0.0009983361064891 3005 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +44701 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.1317402602554797 0.9845127857250529 0.9195415044619336 0.8875000050982297 1.0 0.0013235329769289 0.0049159911398577 0.0043197936814958 1.0 0.0007736943907156 2585 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +44725 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.1316636138436863 0.4630253981438691 0.944024288971064 0.7204611100467462 0.2545335314555431 0.0484215930647349 0.001342173510111 0.0087986463620981 0.3260379920088033 0.0033840947546531 591 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +45075 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.130762992627584 0.724503440376099 0.8587566561291643 0.7204611100467462 1.0 0.0011409783203169 0.0097747651475823 0.0011655773420479 0.8906320789552633 0.0001742919389978 11475 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +45124 CD48 CD2 CD48-CD2 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.1306430649466488 0.9011089648206808 0.4603649459881741 0.6198216015396206 0.4567172527116189 0.0112209532878862 0.0037730551841633 0.0046462829736211 0.9129114045074652 0.0002997601918465 3336 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +45146 CD34 SELP CD34-SELP Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.1305784695314125 0.9303167350027568 0.7760344326192508 0.6198216015396206 0.1314667522621683 0.0335947364052305 0.0025081980663535 0.0048178259560373 0.4052501104944196 0.0003011141222523 3321 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +45154 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.1305642197806723 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.1932385901170197 0.0455125113141721 0.0019741703539695 0.0027714789619551 0.6301990840505185 0.000755857898715 1323 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +45203 HSPG2 LRP1 HSPG2-LRP1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.1304134379634397 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.1619074107723045 0.0203874717835032 0.0043924582301798 0.0094564128256513 0.2954099123246449 0.0035070140280561 1996 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +45305 C1QB LRP1 C1QB-LRP1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.1302103812164999 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.0419710388788557 0.166956519448744 0.0016259176028251 0.0111197916666666 0.1178214026377504 0.0008333333333333 2400 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +45363 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Pericytes Pericytes -> Pericytes 0.130068423656854 0.7487535481622718 0.7754239189773715 1.0 0.0637288077574987 0.0293031867940321 0.0044658211167458 0.0027250926531502 0.3410465780676114 7.993605115907275e-05 12510 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +45455 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.12985820116495 0.7487535481622718 0.9546923450729716 0.6198216015396206 0.1027229557481577 0.0445745465878424 0.0023636916340453 0.0113796640594948 0.4214477792879168 0.001410437235543 1418 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +45494 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.1297566596620197 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.1027229557481577 0.0310998965832685 0.0060205998317523 0.0029472750746599 0.5561895258595165 7.172572084349448e-05 13942 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +45540 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.1296527457122568 0.9356727248601746 0.4638256179742202 0.7204611100467462 0.1750253929104546 0.0446401662952339 0.0019443382738486 0.00328294396091 0.3704744610452605 0.0004580852038479 2183 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +45872 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.128851644839439 0.4636527906642655 0.878254460598671 0.7204611100467462 0.014525360548861 1.0 0.001073951643881 0.0092716214211541 0.1098081922575608 0.0004450378282153 2247 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +45896 A2M LRP1 A2M-LRP1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.1287948576250915 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2100317344087863 0.0203874717835032 0.0059601730128355 0.004660606060606 0.2763461380553941 0.0005818181818181 6875 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +45951 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Pericytes Macrophages -> Pericytes 0.128651832439827 0.8771078809726828 0.8818326005152037 0.8875000050982297 0.0080232294691882 0.8672894033034337 0.0009492266897486 0.0056925357046618 0.0779127523805867 0.0004042037186742 2474 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +45976 CD48 CD2 CD48-CD2 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.1285970215355082 0.928447473463448 0.7763428264267787 0.6198216015396206 1.0 0.0024832440877005 0.0040764828772747 0.0039381153305203 1.0 0.00028129395218 3555 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +46037 THBS2 CD36 THBS2-CD36 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.1284904125492335 0.9197297916541942 0.8587566561291643 1.0 0.0039472834455595 1.0 0.0014434160493714 0.002429115475911 0.0348782390411588 7.825338445887784e-05 12779 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +46178 A2M LRP1 A2M-LRP1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.1281467574961987 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.2100317344087863 0.0350138403862125 0.0019808065973883 0.0074443293630243 0.4346805761312994 0.0005178663904712 1931 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +46240 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.1279802698344135 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.2545335314555431 0.0289462771086338 0.003154656620171 0.0019627085377821 0.4178576518666514 0.0001962708537782 5095 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +46304 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.1278223965420384 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.112230917768503 0.0501711964086628 0.0024018676052068 0.0068328373015872 0.1836526572619445 0.000595238095238 3360 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +46309 THBS2 CD36 THBS2-CD36 Pericytes Pericytes Pericytes -> Pericytes 0.1278155841323338 0.9197297916541942 0.8587566561291643 1.0 0.0087456089304998 0.287457858136305 0.0021958655330771 0.0013555822009059 0.0412280257560824 0.0001598721023181 12510 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +46340 CCN1 CAV1 CCN1-CAV1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.1277174042795234 0.9219165193585238 0.62431395375366 0.6198216015396206 0.2646489893253856 0.0126805820762719 0.0036251680936906 0.0041553748870822 0.8465561760732705 0.0003011141222523 3321 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +46350 VWF LRP1 VWF-LRP1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.1276982173967585 0.9275752708651288 0.7346293219749174 0.7204611100467462 0.1263644540569636 0.0416128058995347 0.0016796793309471 0.0066682630241952 0.2764823299203912 0.0004580852038479 2183 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +46363 VWF LRP1 VWF-LRP1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.1276667498334073 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.1263644540569636 0.0501711964086628 0.0019134583506132 0.0122344406701595 0.2480243165641633 0.0012666244458518 1579 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +46372 VWF SELP VWF-SELP Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.1276494148346864 0.9275752708651288 0.7760344326192508 0.6198216015396206 0.1263644540569636 0.0335947364052305 0.002284114459485 0.0062823355506282 0.3360742288007465 0.0003011141222523 3321 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +46407 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.1275775616673163 0.8840293712888387 0.8817184225858201 0.9429656149619918 0.0061698665784747 1.0 0.0009507629628576 0.0041697416974169 0.0356790748194105 0.0007380073800738 2710 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +46417 CCN1 CAV1 CCN1-CAV1 Macrophages Pericytes Macrophages -> Pericytes 0.1275592650108427 0.8619922139338987 0.9694036398779844 0.8875000050982297 0.0054092055025683 0.5444650460041837 0.0019723736130106 0.0056319051468606 0.1121310212771566 0.0012126111560226 2474 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +46452 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.1274746472895692 0.8730912658940219 0.9255624071030766 0.6198216015396206 0.0057086106530109 1.0 0.0015006408206596 0.0265000603646022 0.2132581518839633 0.0039840637450199 753 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +46482 THBS2 CD36 THBS2-CD36 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.127406086337019 0.8858959974474152 0.8587566561291643 0.8875000050982297 0.0030563796158022 1.0 0.0020725690161746 0.0057347670250896 0.0823421435209526 0.0014336917562724 2790 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +46493 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.1273702463121779 0.7797302331085993 0.7763400818577846 0.909150863993142 0.1132020978253244 0.0467761235673353 0.0014651894364847 0.0051950805767599 0.2921483085397867 0.0006361323155216 1572 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +46550 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.1272425810769857 0.662063103571249 0.956444566971872 0.6198216015396206 0.0236359933700329 1.0 0.0004574939591558 0.0147900763358778 0.1708983212648732 0.0038167938931297 262 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +46585 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.1271396014722411 0.6630837220165452 0.6587114738285964 1.0 0.4103175828613323 0.0042738820064046 0.005514129892423 0.0056635831602794 0.4093276828425056 0.0005663583160279 5297 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +46598 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.1271063469882103 0.8937519114898692 0.7346293219749174 0.7204611100467462 0.0037268694422441 1.0 0.0023919960478239 0.0031437216798953 0.0372235546155526 0.0002736976553234 10961 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +46636 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.1270180194375704 0.8640667164982425 0.7167436199046466 0.7204611100467462 1.0 0.0026482500471321 0.0035539269133504 0.0030995558845299 1.0 0.0003700962250185 2702 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +46669 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.1269382797148625 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.1357656553382984 0.0326412663903893 0.0024143761572118 0.0005170930271039 0.1761413059089742 3.309395373465268e-05 30217 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +46822 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.1266063033255095 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0135527119637784 1.0 0.0010070466289163 0.0073696145124716 0.0546621137051433 0.0022675736961451 1323 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +46914 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.1263716605968345 0.8667347161816407 0.8960994285623033 0.8693461273411047 0.0106228227237899 1.0 0.0005678256776316 0.0113043478260869 0.1199583742085143 0.0017391304347826 575 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +46927 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.1263509905634172 0.7487535481622718 0.7757991160529997 0.946515890536252 0.0637288077574987 0.0279580382843415 0.0041534792850525 0.0023765741212011 0.333263643909955 9.030160736861116e-05 11074 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +46988 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.12621708134978 0.7148920381722296 0.2550748532138862 0.2461374514707439 1.0 0.0267255153180908 0.003370508374119 0.0013343184979137 0.211256610787606 0.0003477051460361 5752 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +47096 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Macrophages Pericytes -> Macrophages 0.1259662556252684 0.7487535481622718 0.7754239189773715 0.8875000050982297 0.0637288077574987 0.0521257226458961 0.002333936082581 0.0131122994652406 0.5483872415766134 0.0004705882352941 2125 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +47146 VWF ITGA9 VWF-ITGA9 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.1258534539323304 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.1263644540569636 0.0565946652887153 0.0015457349567425 0.0058329176100387 0.2157612038360376 0.0004221190375685 2369 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +47183 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.1257586969965082 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0587727051993296 0.166956519448744 0.002277073259614 0.01251494321578 0.1326039378988668 0.0029886431560071 1673 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +47216 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.1256771269550457 0.8924110508951895 0.4596166826058663 0.2461374514707439 1.0 0.0075270071967493 0.0051853163654921 0.0025366670881274 1.0 0.000173852573018 5752 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +47283 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.1255028079154617 0.2451358214448441 0.4614667734221426 0.2461374514707439 0.1327555461750915 0.0312252462757311 0.0338560938097983 0.0140394580223945 0.7646441139192556 0.0017961383026493 13362 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +47313 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.1254100319516906 0.6213271600240247 0.62431395375366 0.8824495942126559 0.1339639999453202 0.0649213179279442 0.0013067770769931 0.0018982373510311 0.0782098599342944 0.0002140869192892 4671 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +47322 THBS2 CD36 THBS2-CD36 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1253833337312247 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.004981832968137 1.0 0.0023471805981417 0.0075862600123228 0.1089266413071405 0.0023105360443622 2164 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +47327 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.125374267458931 0.8818165186409654 0.7346293219749174 0.7204611100467462 1.0 0.0032275631628407 0.0025781941469729 0.0194268635724331 1.0 0.0063291139240506 474 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +47351 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.1253222061352536 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0515877972474039 0.0501711964086628 0.0045955573451249 0.0112909226190476 0.26892765068286 0.0014880952380952 3360 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +47365 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.1252862008138055 0.2534163760166434 0.7746834992804791 0.2461374514707439 0.2100740470724093 0.2295016807597237 0.0016600523708595 0.0095158906134515 0.6535900034272143 0.0011086474501108 902 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +47434 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.1251228898538245 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.0084325366891025 1.0 0.0012648762306388 0.0381679389312977 0.3265901937465465 0.015267175572519 262 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +47779 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.124274034717644 0.7941469661104034 0.663300745568453 0.9592803095773328 0.0323110954490285 0.0373075519081129 0.0060475027518789 0.0312137049941929 0.5889679231315453 0.0060975609756097 1476 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +47800 A2M LRP1 A2M-LRP1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.1242368620081247 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.2100317344087863 0.0144359394371152 0.0039892826423332 0.0061748998664886 0.757573730505261 0.0008900756564307 2247 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +47818 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.1241897007580076 0.7941469661104034 0.8891607331132086 0.7917001487310438 0.0323110954490285 0.0606680526002441 0.003347791057312 0.020359449592811 0.6733069173882379 0.0025273799494524 1187 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +48023 C1QB LRP1 C1QB-LRP1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.123664186160469 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.8040181448318822 0.0064028969591119 0.001418543130524 0.0045417570498915 0.4668985541178393 0.0010845986984815 922 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +48025 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.1236605138350656 0.6582846571368821 0.6587114738285964 1.0 0.4344545964241579 0.0042738820064046 0.0044412822429121 0.0046818954124976 0.3983136028952779 0.0003775722106852 5297 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +48030 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.1236330434104437 0.718867305289982 0.930308383061206 0.7204611100467462 0.0361307801045652 0.1615013370958009 0.0012701766009114 0.0057871569135163 0.1787369333109799 0.0005178663904712 1931 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +48123 A2M LRP1 A2M-LRP1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.1234033641681662 0.919551140852988 0.6207977546603366 0.6198216015396206 0.037376181609614 0.166956519448744 0.0015994404442942 0.0138170851797144 0.1347300864039575 0.0022156573116691 1354 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +48157 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.1233409196040475 0.7941469661104034 0.663300745568453 1.0 0.0323110954490285 0.0265498740402422 0.0077914216379411 0.0276917917762989 0.7035096802503839 0.0054171180931744 1846 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +48236 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.1231591003538063 0.6160088550075702 0.6631822525600675 1.0 0.0548063857429699 0.0267210109213584 0.0058330291191262 0.0065388641941407 0.6870631884645851 0.0003775722106852 5297 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +48292 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.1230195391485192 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0616816618657801 0.0350138403862125 0.0045130375052792 0.0048799685163321 0.4286882590401497 0.0015741833923652 2541 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +48379 VWF LRP1 VWF-LRP1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.1228454525054433 0.955713094717548 0.7346293219749174 0.7204611100467462 1.0 0.0032275631628407 0.0021050867059713 0.0250767165324127 1.0 0.0042194092827004 474 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +48393 C3 LRP1 C3-LRP1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.1228059243149898 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0042375227960614 1.0 0.0028129000876337 0.0077930022021042 0.1380546632248264 0.0007340347443112 4087 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +48706 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.1220389462741972 0.8730912658940219 0.9008184599638702 0.6198216015396206 0.0057086106530109 1.0 0.0011871133855244 0.0248098515030786 0.2001832760143677 0.0026560424966799 753 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +48826 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.1217683885154768 0.4619393085577573 0.9015117569158254 0.7204611100467462 0.1194227711616854 0.0246995741084876 0.003683515257328 0.001500249003984 0.1445538282894989 0.0001992031872509 10040 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +48847 VEGFC FLT1 VEGFC-FLT1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.121716534196017 0.8718210606749883 0.777821334064334 0.6198216015396206 0.1796394187986057 0.0182001711419816 0.0023661611635549 0.0050100200400801 0.6000624722573863 0.000501002004008 1996 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +48930 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.1215249517208745 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.293296467876477 0.0362497659817488 0.0010179695909467 0.0154028436018957 0.5253219150936802 0.0023696682464454 422 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +48970 A2M LRP1 A2M-LRP1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.1213947027249101 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.093381536992618 0.0350138403862125 0.0022471083387246 0.005406195207481 0.3156722295413611 0.0011689070718877 1711 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +49011 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.1213211431951335 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.112230917768503 0.0416128058995347 0.0022852280014524 0.0036477500161404 0.2163840818149781 0.0001936858415649 5163 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +49015 CD48 CD2 CD48-CD2 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.121307035869371 0.4593282471594782 0.8960994285623033 0.6198216015396206 0.0161888123016941 1.0 0.0007715231690159 0.010978956999085 0.1165054236102116 0.000914913083257 1093 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +49053 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.1211961476736616 0.6213271600240247 0.62431395375366 0.7917001487310438 0.2247035641022029 0.009460730808256 0.0048541450341697 0.0057859484110018 0.7183603941121994 0.0012825994014536 2339 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +49103 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.1210734436185586 0.7487535481622718 0.7757991160529997 0.946515890536252 0.1027229557481577 0.0091569531245039 0.0060905644404947 0.0026643977342632 0.6973958325499547 8.788118463836892e-05 11379 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +49161 CD48 CD2 CD48-CD2 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.1209184946460075 0.928447473463448 0.7763428264267787 0.6198216015396206 1.0 0.0016204239758814 0.004317640036608 0.003196745132229 0.5794908143522158 0.000581226387678 3441 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +49213 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1207744940701138 0.6561647292424944 0.8604147465201248 0.6198216015396206 0.1098969873322313 0.0436001007095475 0.0018509221073217 0.009398726426647 0.2692505037810092 0.0014695077149155 1361 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +49439 CD34 SELP CD34-SELP CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.120176489089192 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.1173076386135379 0.0335947364052305 0.002216954826597 0.0010772147535332 0.0906096239007001 8.617718028266115e-05 11604 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +49506 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.1200168055388006 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.1882781599600688 0.0176963220730796 0.0026450562719151 0.0024653718759409 0.4506810693937892 0.0003011141222523 3321 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +49607 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Macrophages Macrophages -> Macrophages 0.1197669458887625 0.7487535481622718 0.7754239189773715 1.0 0.0338862305197021 0.0521257226458961 0.0028778402151236 0.0086175012944744 0.3604041973482342 0.000813669650122 2458 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +49750 VWF SELP VWF-SELP T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1194524153678579 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0036144684673052 1.0 0.0023217852944094 0.0071690054911531 0.040311130267564 0.0012583892617449 4768 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +49901 HSPG2 LRP1 HSPG2-LRP1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.1190330299032466 0.9253089325030373 0.7346293219749174 0.7204611100467462 0.0022161183602947 1.0 0.0026208537353312 0.0030813569361857 0.0301301416594484 0.0005126102111954 9754 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +49909 VWF ITGA9 VWF-ITGA9 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.1190189296124296 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.1263644540569636 0.0487643047611538 0.0012832560140999 0.0056998100063331 0.2231068202996048 0.0006333122229259 1579 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +49986 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.1188002251044999 0.6303682835571691 0.4614667734221426 0.2461374514707439 0.0272543760657653 0.1609352200462838 0.0089516489765668 0.0090929351459772 0.1910241968651363 0.0005460218408736 12820 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +50120 A2M LRP1 A2M-LRP1 Macrophages Macrophages Macrophages -> Macrophages 0.1184693473084562 0.919551140852988 0.8604147465201248 1.0 0.037376181609614 0.0436001007095475 0.002144211213645 0.0069839978302142 0.2000744408156478 0.000813669650122 2458 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +50133 C1QB LRP1 C1QB-LRP1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.1184409416377911 0.9256868304646206 0.7346293219749174 0.7204611100467462 1.0 0.0032275631628407 0.0017457804179738 0.0251150306748466 1.0 0.0061349693251533 326 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +50330 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.1179564952175395 0.8924110508951895 0.7462743270426613 0.7204611100467462 1.0 0.0022591041672132 0.0024849475629686 0.0092560732227651 1.0 0.0007570022710068 1321 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +50337 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.1179395091979762 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0255753403203798 0.1076178292491983 0.0055718547680634 0.0036433829981031 0.3052452844379263 0.0001838404265097 10879 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +50365 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.1178818886124845 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0683610513379333 0.0501711964086628 0.0043915897439027 0.0148780388317833 0.2524373025550103 0.0088105726872246 1362 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +50414 CCN1 CAV1 CCN1-CAV1 Pericytes Macrophages Pericytes -> Macrophages 0.1177401385590284 0.9219165193585238 0.8818704453527788 0.8875000050982297 0.2646489893253856 0.0051192928876727 0.002725209009797 0.0039686274509803 0.7476684554745409 0.0004705882352941 2125 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +50523 MMP2 PECAM1 MMP2-PECAM1 Macrophages Pericytes Macrophages -> Pericytes 0.1174590113057876 0.9330801352629944 0.930308383061206 0.8875000050982297 0.0088108219576754 0.1615013370958009 0.0023955702361271 0.0053556992724333 0.1654113199272036 0.0012126111560226 2474 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +50607 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.1172808992900707 0.4601010570874773 0.8604147465201248 0.7204611100467462 0.0587727051993296 0.0436001007095475 0.0035606355065588 0.0038408864541832 0.0900468301319293 0.0002988047808764 10040 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +50627 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.1172280793419601 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.141548283585814 0.0176963220730796 0.0032789118247434 0.0076195652173913 1.0 0.0004347826086956 2300 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +50649 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1171889342555768 0.6319926036888139 0.8604147465201248 0.6198216015396206 0.0616816618657801 0.0436001007095475 0.0028575103500598 0.0112233651726671 0.3208676014230137 0.002939015429831 1361 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +50659 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.1171754482944447 0.8640667164982425 0.956444566971872 0.9429656149619918 0.002676946692949 1.0 0.001240714736357 0.0026291512915129 0.030379663489699 0.0014760147601476 2710 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +50769 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.1169109457875297 0.6242573126045354 0.6176321640000088 1.0 0.1932385901170197 0.0032616151102094 0.0105077357920243 0.0028160594046944 0.8918394340582262 0.0009439305267132 5297 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +50787 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.1168766954075875 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0492631209980634 0.0587195251380622 0.0023017526500959 0.0011353064683971 0.0800458190143065 6.618790746930536e-05 30217 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +50790 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1168725883079867 0.6213271600240247 0.942159351720962 0.6198216015396206 0.0083518627398662 1.0 0.0008409603277319 0.0047443006777572 0.0699136732724676 0.0004621072088724 2164 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +50842 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.1167296219571846 0.724503440376099 0.6176321640000088 0.6198216015396206 1.0 0.0032616151102094 0.0027964933467362 0.0032376967523411 1.0 0.0005977286312014 1673 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +50890 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.1166231210075817 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2966815529783992 0.0104714078116759 0.0045282243162126 0.0027540790532 0.378021503436719 8.617718028266115e-05 11604 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +50988 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.1163812116178511 0.6626993710110988 0.6207977546603366 0.8824495942126559 0.0515877972474039 0.166956519448744 0.0007946660901879 0.0027296082209377 0.0289219689435801 0.0002140869192892 4671 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +51036 COL4A2 CD93 COL4A2-CD93 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.1162417444809022 0.8840293712888387 0.4630027772793905 0.7204611100467462 0.5544396796022323 0.0058437228618857 0.0025820551360114 0.0021530004580852 0.6533496276492348 0.0004580852038479 2183 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +51076 VWF LRP1 VWF-LRP1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.116092559293624 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.1263644540569636 0.0104714078116759 0.0051835703957386 0.0041232104240234 0.3461684487659758 0.0015055706112616 3321 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +51107 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.116021110620438 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.141548283585814 0.0326667674102811 0.0018835914389713 0.050592885375494 1.0 0.0118577075098814 253 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +51117 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.1160079835288344 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.1932385901170197 0.0063011237754475 0.0065578236494869 0.0053442028985507 1.0 0.0017391304347826 2300 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +51180 C3 LRP1 C3-LRP1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.1158363686278307 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0691889863216023 0.0350138403862125 0.0028042226550879 0.0055961426066627 0.4916016616422326 0.0011689070718877 1711 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +51203 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.1157769662801727 0.6303682835571691 0.4614667734221426 1.0 0.0272543760657653 0.0312252462757311 0.0097287114088876 0.0043176789520871 0.2351577811080893 0.0004024864719824 22361 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +51250 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.1156428816330092 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.1661175896787547 0.0362497659817488 0.0012198221490075 0.0080252221266838 0.2737043344465871 0.0008598452278589 1163 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +51286 COL4A1 CD93 COL4A1-CD93 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.1155525390989994 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.4857192596400828 0.0042738820064046 0.0036165240953924 0.0081710185129349 0.5905491240633378 0.0008442380751371 2369 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +51417 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.1152646049088071 0.4604235282221027 0.4630027772793905 0.8293805866303694 0.454846709299195 0.0058437228618857 0.0049902753586918 0.0011033388620465 0.2689260698855695 0.0002019182231196 9905 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +51434 CD48 CD2 CD48-CD2 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.1152239177463232 0.9011089648206808 0.8581827408615759 0.8693461273411047 0.4567172527116189 0.003930762149527 0.0019390029223203 0.0024096385542168 0.6460348344136586 0.0008032128514056 1245 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +51444 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.1152043161082771 0.662063103571249 0.930308383061206 0.6198216015396206 0.0491302556793708 0.1615013370958009 0.0007717711959929 0.0089050131926121 0.3362066364419397 0.0026385224274406 379 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +51448 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.1151857806761798 0.9097736029185508 0.663300745568453 0.7917001487310438 0.0430965463818576 0.0265498740402422 0.0042725036829224 0.0220284158375302 0.5596316737997148 0.0051590713671539 1163 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +51641 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1147693853013063 0.6303642896310324 0.9015117569158254 0.6198216015396206 0.141548283585814 0.0246995741084876 0.0018557949595407 0.0106355620867009 0.5413401220973225 0.0007347538574577 1361 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +51668 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.1146866480867721 0.9097736029185508 0.4614667734221426 0.6198216015396206 0.0430965463818576 0.0312252462757311 0.006498115304773 0.0043111130915248 0.2348001785123366 0.0009357454772301 6412 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +51674 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.1146805414837991 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0492631209980634 0.0416128058995347 0.0031286819576316 0.0032967699452415 0.1088620296509194 0.000467872738615 6412 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +51681 A2M LRP1 A2M-LRP1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.1146625603466893 0.8937519114898692 0.7346293219749174 0.7204611100467462 1.0 0.0032275631628407 0.0014885210847779 0.0190752461322081 1.0 0.0021097046413502 474 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +51734 COL4A2 CD93 COL4A2-CD93 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.1145246883023757 0.8840293712888387 0.6587114738285964 0.6198216015396206 0.5544396796022323 0.0042738820064046 0.0026380714841845 0.0073870831574504 0.6284582307150327 0.0004221190375685 2369 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +51812 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.1143348634088348 0.8023917560710954 0.9008184599638702 0.6198216015396206 0.0085367158000785 1.0 0.0005840941161582 0.0082758047076436 0.0667749945148065 0.000914913083257 1093 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +51817 VWF LRP1 VWF-LRP1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.1143163189459434 0.955713094717548 0.6207977546603366 0.6198216015396206 1.0 0.0016667952436519 0.0036409853642158 0.0092159251186049 1.0 0.001410437235543 1418 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +51852 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.1141944803659428 0.6213271600240247 0.9694036398779844 0.6198216015396206 0.0083518627398662 0.5444650460041837 0.0013062363353269 0.0053574907461523 0.106667440800888 0.0011689070718877 1711 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +51895 C1QB LRP1 C1QB-LRP1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.1140566159974048 0.8703788833238396 0.2550748532138862 0.2461374514707439 0.8040181448318822 0.0267255153180908 0.0018748854563668 0.0182845744680851 1.0 0.0013297872340425 752 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +51902 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.1140304116510488 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0215813276111062 0.1332188634280341 0.0018134817082413 0.0051765575892031 0.1951052683179106 0.0011092623405435 1803 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +51913 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.114006937624255 0.7800321422220979 0.930308383061206 0.6198216015396206 0.0213929720256037 0.1615013370958009 0.0014129635980774 0.0031821378340365 0.1201408504103798 0.00028129395218 3555 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +52062 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.1136642650132085 0.6303682835571691 0.4614667734221426 0.8293805866303694 0.0272543760657653 0.12709315903692 0.002580445643885 0.0042014860689308 0.1979275678045932 0.0001389467833819 7197 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +52108 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.1135718917214405 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0548063857429699 0.0293031867940321 0.0045132051607149 0.0068512754463167 0.8574402208540921 0.0007870916961826 2541 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +52111 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1135652368433623 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0031934983073077 1.0 0.0019504701906282 0.0095427852348993 0.0568970164110783 0.0006291946308724 4768 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +52170 C3 LRP1 C3-LRP1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.1134181770739378 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0691889863216023 0.0416128058995347 0.0025691127726929 0.0125531161473087 1.0 0.0007082152974504 1412 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +52221 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.1133084921916886 0.7487535481622718 0.8622452992050237 0.6198216015396206 0.1027229557481577 0.0254056950469408 0.0020264568629949 0.0028365850283658 0.4457141919356244 0.0005073566717402 1971 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +52227 VWF ITGA9 VWF-ITGA9 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.1132921739234433 0.955713094717548 0.6252253442669611 0.6198216015396206 1.0 0.0047273851759697 0.0012076556483329 0.0259324009324009 1.0 0.0032051282051282 312 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +52242 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.1132473700375211 0.4625081978296446 0.4642836810638544 1.0 0.149715856631667 0.0761275033764692 0.0008618890475026 0.0007321646791117 0.0705145525619749 1.0534743584341158e-05 94924 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +52251 HSPG2 LRP1 HSPG2-LRP1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.1132253321930623 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.1619074107723045 0.0104714078116759 0.0036626304227422 0.0034460838435544 0.2880477098675343 0.000903342366757 3321 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +52268 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.1131689457316509 0.9067635403815892 0.930308383061206 0.9429656149619918 0.0106922602624424 0.1615013370958009 0.0015293181729883 0.0050341827221876 0.1554812483811205 0.0003107520198881 3218 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +52368 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.1129283486980292 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0031934983073077 1.0 0.0018467771066586 0.0080746644295302 0.0510081794372218 0.0006291946308724 4768 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +52422 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.1127933114490755 0.8818165186409654 0.6207977546603366 0.6198216015396206 1.0 0.0016667952436519 0.0036409853642158 0.0090503055947343 1.0 0.001410437235543 1418 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +52448 CCN1 CAV1 CCN1-CAV1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.112738557376758 0.7324582304061453 0.942159351720962 0.7204611100467462 0.0025580826958339 1.0 0.0016143514234339 0.0141169154228855 0.2080318005808282 0.0093283582089552 536 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +52449 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.112737968316857 0.9845127857250529 0.2491545808994955 0.2461374514707439 1.0 0.0109188419829382 0.0031144034403612 0.0083534136546184 1.0 0.0004819277108433 2075 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +52497 C3 LRP1 C3-LRP1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.1126108670465057 0.7148920381722296 0.6207977546603366 0.6198216015396206 1.0 0.0016667952436519 0.0044477323961963 0.0061141304347826 1.0 0.0002362948960302 4232 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +52591 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.112349697048401 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0053032910137447 1.0 0.0010764531582654 0.0106382978723404 0.146506965777812 0.0005910165484633 1692 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +52603 C3 LRP1 C3-LRP1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.1123051566498971 0.6319926036888139 0.8604147465201248 0.6198216015396206 0.0334108479684367 0.0436001007095475 0.0040863478882877 0.0051874455100261 0.1483051805503287 0.002034292356873 3441 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +52667 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.1121142719021656 0.724503440376099 0.7763054211764489 0.7204611100467462 1.0 0.0017638974017382 0.0027784617569586 0.0043527630582891 0.625092652072936 0.0015140045420136 1321 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +52673 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.1121017835878151 0.6342079770588467 0.6571792026963191 1.0 0.0673400749834054 0.1615138601457002 0.0004377903674318 0.0004248128463404 0.0406047902553816 4.720142737116371e-06 423716 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +52704 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.1120133432714641 0.6249837837987587 0.7746834992804791 0.8693461273411047 0.1661175896787547 0.0090444648829713 0.0031234342516612 0.0071040868454661 0.9995455793059376 0.0019157088122605 1044 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +52820 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.1117847303625014 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0161193721503025 0.1615013370958009 0.0020619730825042 0.0086060783167738 0.2657996092315451 0.0011689070718877 1711 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +52821 A2M LRP1 A2M-LRP1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.1117840893246856 0.4648000335061383 0.8604147465201248 0.7204611100467462 0.2100317344087863 0.0436001007095475 0.0007394639305804 0.0069091934574168 0.1979314786581758 0.0016920473773265 591 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +52853 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.1117112107672926 0.6160088550075702 0.9546923450729716 0.7917001487310438 0.0548063857429699 0.0445745465878424 0.0017086322469426 0.0183900069396252 0.6810770111730804 0.0010905125408942 917 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +52882 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.11163961002309 0.7789175740361626 0.6207977546603366 0.8693461273411047 0.0492631209980634 0.0501711964086628 0.0018633592670529 0.010483184333759 0.1778693284324409 0.003831417624521 1044 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +52949 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.1114656352657934 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0411127335336962 0.0518891167572028 0.0025264579094048 0.0088124410933082 0.3217489361080594 0.000942507068803 2122 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +52956 CD48 CD2 CD48-CD2 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.1114366333577505 0.9011089648206808 0.4603649459881741 0.6198216015396206 0.4567172527116189 0.0071918009517169 0.0022674306147033 0.0031869688385269 0.7789358200767967 0.0007082152974504 1412 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +52998 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.1113086740612362 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0069047442087267 1.0 0.0009431072134652 0.0006869479882237 0.037346190228595 0.0001962708537782 5095 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +53014 C3 LRP1 C3-LRP1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.1112812142025821 0.6319926036888139 0.6207977546603366 0.909150863993142 0.0334108479684367 0.0501711964086628 0.0031760657654417 0.0043372657876474 0.1247964140881288 0.0005204718945176 5764 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +53151 MMRN2 CD93 MMRN2-CD93 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.1109601714273545 0.9845127857250529 0.7779918296243433 0.6198216015396206 1.0 0.001079730675535 0.0036409853642158 0.0096967559943582 1.0 0.001410437235543 1418 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +53154 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.1109520112429487 0.9097736029185508 0.8445107771175474 0.8693461273411047 0.0430965463818576 0.0218093597373452 0.0029716158245462 0.0111293559569421 0.6031591653306024 0.0028735632183908 1044 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +53160 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.1109254522108907 0.8978557803479422 0.885766439573873 0.8875000050982297 0.0477973731763516 0.0331922776397286 0.0016636009040538 0.0019115890083632 0.2122083420296457 0.0003584229390681 2790 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +53321 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.1105081886900253 0.7324582304061453 0.62431395375366 0.6198216015396206 1.0 0.0019304335593669 0.0033285548105033 0.0022684310018903 0.560059446219714 0.0002362948960302 4232 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +53387 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1103166969476051 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0548063857429699 0.0521257226458961 0.0021309299384565 0.0170663282345868 0.7137540359885619 0.0007347538574577 1361 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +53417 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.110217857150215 0.4625081978296446 0.4642836810638544 0.8293805866303694 0.0704104148800194 0.0761275033764692 0.001877907143545 0.0010884164698253 0.1048250517410055 0.0001389467833819 7197 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +53423 C3 LRP1 C3-LRP1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.1101930344587287 0.6319926036888139 0.8604147465201248 0.6198216015396206 0.0691889863216023 0.0436001007095475 0.001760804743189 0.0071034905082669 0.2030834714947725 0.0012247397428046 1633 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +53488 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.1100096240753483 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.3309594876493178 0.0203874717835032 0.0014745051189166 0.004827784983427 0.1508157019972508 0.0012970168612191 1542 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +53496 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.1099882738196119 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0548063857429699 0.0491709261488903 0.0022178576943827 0.0171331240398103 0.7731746182612456 0.0007347538574577 1361 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +53560 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.1098393852964061 0.6160088550075702 0.9546923450729716 0.9318789094584046 0.0255753403203798 0.0445745465878424 0.002810790649486 0.0045545273090183 0.168677687676587 0.0003992015968063 5010 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +53578 C1QB LRP1 C1QB-LRP1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.1097913536355056 0.8703788833238396 0.6207977546603366 0.909150863993142 0.0419710388788557 0.0501711964086628 0.0016931968430997 0.0044673837612768 0.1064043267458236 0.0001734906315058 5764 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +53586 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.1097819066114536 0.7487535481622718 0.8628183098412396 0.6198216015396206 0.1027229557481577 0.0339152418223636 0.0012548551164774 0.0022369816890364 0.1709105640286512 0.0005073566717402 1971 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +53641 CD48 CD2 CD48-CD2 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.1096258333620651 0.9011089648206808 0.6614977577544194 0.7917001487310438 0.4567172527116189 0.0024251058581756 0.0033207011332554 0.006358626536668 1.0 0.0004239084357778 2359 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +53707 VWF LRP1 VWF-LRP1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.1094436416119673 0.9275752708651288 0.9078204025796472 0.9429656149619918 0.1263644540569636 0.0064028969591119 0.0026748194077388 0.0024750199227609 0.2580216505660722 0.0006743088334457 2966 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +53726 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.1093952824691012 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0616816618657801 0.0144359394371152 0.0054126583074369 0.002936 0.5013945054162793 0.00128 3125 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +53744 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.1093709358561225 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0016575843792215 1.0 0.0022784534472155 0.0054740780976522 0.0938383617338443 0.0007604562737642 3945 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +53750 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.1093575538729381 0.718867305289982 0.6331674633943454 0.6198216015396206 1.0 0.0023576674662702 0.0025714174599548 0.0019130998702983 0.9173375334379752 0.0006485084306095 1542 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +53819 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.1091941089885939 0.2534163760166434 0.4638256179742202 0.2461374514707439 0.2100740470724093 0.0446401662952339 0.0062478282505497 0.0027690465499176 0.312482040633314 0.0001496781918874 13362 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +53898 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.1090058800683877 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0587727051993296 0.0350138403862125 0.0027090597929805 0.0016294599961565 0.0572846032304509 0.0001281147908526 15611 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +53906 COL4A2 CD93 COL4A2-CD93 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.1089869940967103 0.8840293712888387 0.7779918296243433 0.6198216015396206 1.0 0.001079730675535 0.0036409853642158 0.0064174894217207 1.0 0.001410437235543 1418 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +53931 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.1089306309010804 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.0051524613572059 0.8672894033034337 0.0008065039596479 0.0112463126843657 0.1539263380735701 0.0044247787610619 452 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +53950 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.1088917404253474 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.8713412494740926 0.0144613249009303 0.0005896184763773 0.0179990649836372 0.1043088118819929 0.0014025245441795 713 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +53981 CCN1 CAV1 CCN1-CAV1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1088060923692968 0.9219165193585238 0.62431395375366 0.6198216015396206 0.4529166025129413 0.0082011408892332 0.0012521645212153 0.0049140049140049 0.8241319279133748 0.0024570024570024 407 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54017 CCN1 CAV1 CCN1-CAV1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.1087357802144954 0.9219165193585238 0.62431395375366 0.6198216015396206 0.2646489893253856 0.009460730808256 0.0018504431081324 0.0037365421152628 0.4639142411697136 0.0006333122229259 1579 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54027 CD34 SELP CD34-SELP Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.1087052724503237 0.7871981482311898 0.8819126042133903 0.7827641335561659 0.0038506427265089 1.0 0.000788539114199 0.0119565217391304 0.1445862567085089 0.0043478260869565 460 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +54063 C3 LRP1 C3-LRP1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.1086101407454196 0.6319926036888139 0.6207977546603366 0.8693461273411047 0.0691889863216023 0.0203874717835032 0.0034116580349151 0.0079518072289156 1.0 0.0016064257028112 1245 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54246 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.1081530616904391 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.0683610513379333 0.0350138403862125 0.0022079651905196 0.0063079003394901 0.2700477326486901 0.0010357327809425 1931 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +54299 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes B Cells Pericytes -> B Cells 0.1079995935210452 0.7487535481622718 0.9546923450729716 0.6198216015396206 0.0637288077574987 0.0445745465878424 0.0012607742448243 0.0086376464551441 0.319896694468522 0.0009407337723424 1063 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +54342 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.1078964443777908 0.6626993710110988 0.6207977546603366 1.0 0.0135527119637784 0.166956519448744 0.0016948980721019 0.0054747970549367 0.0580090245848137 0.0003775722106852 5297 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54465 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.10763747724636 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.1098969873322313 0.0144359394371152 0.0026550255254379 0.0039333333333333 0.4825649113478631 0.00032 3125 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54492 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.1075581895657252 0.724503440376099 0.7373999388878224 0.8767341187813953 1.0 0.0009761781830445 0.0033862155056517 0.0027007745617611 1.0 0.0004076640847941 2453 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +54540 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.1074461102437486 0.2542249848376565 0.252518874138558 1.0 0.1711385759005754 0.0322196586137726 0.0043467240118784 0.0013944985698001 0.2440318794497415 7.74243499580618e-05 77495 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54562 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.1073828298311806 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.149715856631667 0.0293997450046583 0.0015651522118123 0.0023313219967087 0.1437357681883899 0.0002742731760833 3646 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +54624 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.1072570445542574 0.9067635403815892 0.9015117569158254 0.8875000050982297 0.0411127335336962 0.0246995741084876 0.0020665833738883 0.0034719535783365 0.1767191765410446 0.0007736943907156 2585 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +54688 HSPG2 LRP1 HSPG2-LRP1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.1070981989725616 0.8818165186409654 0.9078204025796472 0.9429656149619918 0.1619074107723045 0.0064028969591119 0.0019282918586084 0.0022664269124147 0.2681901040062887 0.0003371544167228 2966 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +54695 CD48 CD2 CD48-CD2 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.1070853503734196 0.928447473463448 0.4603649459881741 0.6198216015396206 1.0 0.0062523288579129 0.0009103465999346 0.0105189340813464 0.1243261209494866 0.002805049088359 713 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +54801 C3 LRP1 C3-LRP1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.1068434446012456 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0616816618657801 0.0104714078116759 0.007414847046688 0.0074239130434782 0.7305448403266509 0.0030434782608695 2300 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54852 A2M LRP1 A2M-LRP1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.1067015484831032 0.8937519114898692 0.6207977546603366 0.6198216015396206 1.0 0.0016667952436519 0.002574565441238 0.0052009873060648 1.0 0.0007052186177715 1418 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54858 VWF LRP1 VWF-LRP1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.1066784616847409 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.1263644540569636 0.0203874717835032 0.0016028880306501 0.0058810803425031 0.2753684594604679 0.000501002004008 1996 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +54910 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.1065340304306026 0.7324582304061453 0.62431395375366 0.6198216015396206 0.2376713873232418 0.009460730808256 0.0022938951126286 0.0033284385707293 0.4132457245731559 0.0014684287812041 1362 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +54919 VWF LRP1 VWF-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1065113652839765 0.955713094717548 0.6207977546603366 0.6198216015396206 1.0 0.0028784826949613 0.0013793136196418 0.0115311592584319 1.0 0.0024570024570024 407 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +54925 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Pericytes Pericytes -> Pericytes 0.1064957340490222 0.7487535481622718 0.7757991160529997 1.0 0.0637288077574987 0.0091569531245039 0.0043034498108111 0.0012099411379986 0.3166974271220639 7.993605115907275e-05 12510 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +54940 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.1064677082514495 0.7789175740361626 0.6207977546603366 1.0 0.0492631209980634 0.0203874717835032 0.0029990156589959 0.0014090382781637 0.0440171005526879 0.0002043318348998 19576 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +55025 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.1062684974695127 0.9097736029185508 0.663300745568453 0.7917001487310438 0.0430965463818576 0.0222186841038061 0.0031481846834453 0.0143596806692682 0.5678249218856093 0.0010712372790573 1867 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +55037 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.1062413836931677 0.4629984640915818 0.2550748532138862 0.2461374514707439 0.3309594876493178 0.0267255153180908 0.0055928799189907 0.0048654574254366 0.290844249453739 0.0006954102920723 5752 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +55148 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.1059753236058923 0.4619393085577573 0.7167436199046466 0.8767341187813953 0.1194227711616854 0.0326667674102811 0.0012508777810383 0.0064461883408071 0.1364584923231647 0.0004076640847941 2453 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +55215 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.1058060138295983 0.7487535481622718 0.8950084308969304 0.6198216015396206 0.0131092554497256 0.4247538686915498 0.0006066057212105 0.0086092036486624 0.0887478303279204 0.0011273957158962 887 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +55271 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.1056657423424538 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0069047442087267 0.8672894033034337 0.0005109250888798 0.0027619540825133 0.0289201502316336 0.0005178663904712 1931 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +55310 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.1055676410343793 0.7941469661104034 0.4614667734221426 0.2461374514707439 0.0526353932596327 0.1609352200462838 0.0018114834724994 0.0514177180843847 1.0 0.0056980056980056 351 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +55367 CD48 CD2 CD48-CD2 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.1053945499382375 0.9011089648206808 0.7763428264267787 0.6198216015396206 0.4567172527116189 0.0024832440877005 0.0027870271368428 0.0037989479836353 0.971182270202388 0.0005844535359438 1711 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +55412 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.1052778897485971 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0338862305197021 0.0310998965832685 0.0052062964663809 0.0031502227524372 0.5944884188429806 0.000102522042239 9754 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +55454 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.105171677639936 0.8818165186409654 0.7346293219749174 0.7204611100467462 0.0026436039558049 1.0 0.0010968159598353 0.0024011900779531 0.0234793302750401 9.123255177447311e-05 10961 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +55487 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1050923412170291 0.8818165186409654 0.6207977546603366 0.6198216015396206 1.0 0.0028784826949613 0.0013793136196418 0.0147420147420147 1.0 0.0024570024570024 407 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +55503 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.1050531413057782 0.9470274865242416 0.8818326005152037 0.9429656149619918 0.0061455194924501 0.1993723722552783 0.0013930998052421 0.0017527675276752 0.0766008407946301 0.0007380073800738 2710 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +55539 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.1049696857828222 0.4630253981438691 0.4630027772793905 1.0 0.2545335314555431 0.0058437228618857 0.0041952567051745 0.0012969008541657 0.3935575986457247 4.472071910916328e-05 22361 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +55571 C1QB LRP1 C1QB-LRP1 Macrophages B Cells Macrophages -> B Cells 0.1048711309987946 0.9256868304646206 0.6207977546603366 0.6198216015396206 1.0 0.0016667952436519 0.0022406187226116 0.0065758845437616 1.0 0.0009310986964618 1074 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +55581 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.1048182829677808 0.8498991475190484 0.6207977546603366 0.7917001487310438 0.018166235813628 0.166956519448744 0.0010468181130114 0.0039501874665238 0.0418547974583966 0.0016068559185859 1867 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +55645 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.1046149978467577 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.1098969873322313 0.0203874717835032 0.0018142124006037 0.0055181226765799 0.3271917581445313 0.0004646840148698 2152 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +55659 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.1045871856960073 0.6160088550075702 0.9008184599638702 0.909150863993142 0.0052742025956585 0.3180524283074206 0.0015465055648506 0.0079230001760666 0.1101028756136318 0.0019367333763718 1549 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +55670 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.1045470262480169 0.9097736029185508 0.663300745568453 0.7917001487310438 0.0430965463818576 0.0373075519081129 0.001699900697962 0.0255952380952381 0.482953696967866 0.00078125 1280 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +55673 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes B Cells Pericytes -> B Cells 0.1045453839504102 0.7487535481622718 0.9460955677032749 0.6198216015396206 0.0637288077574987 0.0376195773145198 0.0012403240210466 0.0085093645770974 0.3096031744047555 0.0009407337723424 1063 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +55696 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.104477303454176 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.112230917768503 0.0203874717835032 0.0017625009575456 0.0015926535087719 0.0944348526106199 3.289473684210526e-05 30400 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +55810 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.1041671065089925 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0255753403203798 0.0521257226458961 0.0032367981971141 0.0051914084172148 0.2171169251709754 0.000871839581517 3441 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +55987 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.1036821696944746 0.6249837837987587 0.6580560501976399 0.9161861017439124 0.0244483651952677 0.1973932010691654 0.0006831570226014 0.0120087336244541 0.2179937068149567 0.0021834061135371 458 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +56003 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.1036543054310668 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0683610513379333 0.0203874717835032 0.0049952175120616 0.0027616161616161 0.0862704286729536 0.0013090909090909 6875 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +56035 A2M LRP1 A2M-LRP1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.1035902799391203 0.7741139100414175 0.6207977546603366 0.8693461273411047 0.093381536992618 0.0203874717835032 0.0015535986821902 0.0069946452476572 0.4147407388914244 0.0008032128514056 1245 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +56088 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.1034260292191114 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0141923232885854 0.1615013370958009 0.0014691324056376 0.0042053445850914 0.1298824977252029 0.00028129395218 3555 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +56153 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.1032330431746705 0.6561647292424944 0.6207977546603366 1.0 0.112230917768503 0.0587195251380622 0.0004508629496908 0.0003349334617212 0.0430659432829134 4.720142737116371e-06 423716 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +56192 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.1031266139262852 0.7800321422220979 0.930308383061206 0.6198216015396206 0.0113788029360913 0.1615013370958009 0.0014552657232295 0.0035067212156633 0.1323954181040277 0.0011689070718877 1711 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +56367 C3 LRP1 C3-LRP1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.1026523609615154 0.6319926036888139 0.6207977546603366 1.0 0.0334108479684367 0.0104714078116759 0.0085242833442498 0.0015663303790307 0.1541336179379162 0.0004714312653215 21212 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +56378 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.1026205970609037 0.7941469661104034 0.663300745568453 0.9161861017439124 0.0526353932596327 0.0222186841038061 0.0020692528249366 0.0262008733624453 1.0 0.0043668122270742 458 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +56430 CCN1 CAV1 CCN1-CAV1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.1024931538585048 0.9219165193585238 0.62431395375366 0.6198216015396206 0.4529166025129413 0.0034299077593249 0.0020917209409601 0.0098290598290598 1.0 0.0096153846153846 312 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +56431 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.1024842839675255 0.6213271600240247 0.62431395375366 1.0 0.1339639999453202 0.0638329144736252 0.0003492809616774 0.000198009987822 0.051692161438673 2.3600713685581854e-06 423716 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +56471 VWF ITGA9 VWF-ITGA9 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1023902452070975 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0019871862905238 1.0 0.0015707960816313 0.0054612670139472 0.0609804648812923 0.0018484288354898 2164 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +56504 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.1022998320151259 0.4625081978296446 0.7763400818577846 0.2461374514707439 0.3558005706994493 0.0293997450046583 0.0012397852935283 0.0073360843649701 0.4523003356818465 0.0013755158184319 727 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +56583 C3 LRP1 C3-LRP1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.1021007136984062 0.6319926036888139 0.6207977546603366 0.909150863993142 0.0691889863216023 0.0104714078116759 0.0043836013291113 0.0023517986826549 0.2314270631994945 0.0005066711704104 5921 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +56591 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.1020858737453289 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0048313935743179 1.0 0.000646470713104 0.0158301158301158 0.1208187533631709 0.0054054054054054 370 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +56614 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.102022402255588 0.7797302331085993 0.8381155706134242 0.6198216015396206 0.8713412494740926 0.0029095741067474 0.0010980828628374 0.0245245245245245 0.7746300746174279 0.003003003003003 333 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +56634 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.1019660440539332 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.1027229557481577 0.0292791515533623 0.0015058909700995 0.0216724204065976 0.5117373089557218 0.0042194092827004 474 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +56642 A2M LRP1 A2M-LRP1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.1019484448405223 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.093381536992618 0.0144359394371152 0.0019120683296875 0.0029459334565619 0.3614247755853834 0.0004621072088724 2164 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +56689 C3 LRP1 C3-LRP1 Pericytes Pericytes Pericytes -> Pericytes 0.1018483799419343 0.8911088195487638 0.9078204025796472 1.0 0.0091898156146168 0.0350138403862125 0.0042879123741067 0.0011930455635491 0.1048049027123381 0.0002398081534772 12510 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +56691 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.1018424164076954 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0548063857429699 0.0292373734098458 0.0039678190788086 0.0066400345497732 1.0 0.001187648456057 1684 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +56732 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.1017448665886711 0.7783550150988336 0.7779918296243433 1.0 0.0267593032157803 0.0627790816848129 0.0010905065715415 0.0028920468711044 0.0634267227775514 0.00024931438544 4011 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +56764 MMP2 PECAM1 MMP2-PECAM1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.1016271065980691 0.6303642896310324 0.956444566971872 0.6198216015396206 0.0024819960935566 1.0 0.0011877710317745 0.0110172299536116 0.1000033579279213 0.001325381047051 1509 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +56803 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.1015212502248891 0.7797302331085993 0.9130058539314824 0.6198216015396206 0.1132020978253244 0.0132636308162813 0.0016524837187086 0.0027556644213104 0.3577309813119091 0.0006123698714023 1633 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +56870 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.1013610554474079 0.4619393085577573 0.956444566971872 0.7204611100467462 0.0051428381563772 1.0 0.0006624623415509 0.0151585820895522 0.1751563800638415 0.001865671641791 536 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +56918 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.1012056059842098 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.293296467876477 0.0046263543438723 0.0022603510876396 0.0029734675205855 1.0 0.000914913083257 1093 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +56952 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.1011236137511595 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0131092554497256 0.1076178292491983 0.0030570757446344 0.0021771404400726 0.1824024137010267 9.123255177447311e-05 10961 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +57206 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.1004095861542152 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.0683610513379333 0.0144359394371152 0.0034293009110862 0.0042649458537309 0.3732116763632346 0.0013351134846461 2247 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +57315 CD34 SELP CD34-SELP CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.1001530326550326 0.7168245244832976 0.4623922682986163 1.0 0.1173076386135379 0.0222228052993653 0.0011679710084326 0.0004845982048796 0.1294911703942032 1.0534743584341158e-05 94924 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +57322 A2M LRP1 A2M-LRP1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.1001448969791092 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2100317344087863 0.0104714078116759 0.0025644710698048 0.0046889295516925 0.6435967030721766 0.0018298261665141 1093 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +57327 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.1001289249092511 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0149256517769723 0.1076178292491983 0.0035751047387532 0.0048915413124046 0.4098168982020812 0.000599520383693 3336 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +57328 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.1001274628237569 0.4636527906642655 0.4630488285702799 1.0 0.0666348171285698 0.0359289752254096 0.0019604290809218 0.0011807213368604 0.2978351526417017 1.2904058326343637e-05 77495 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +57331 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.1001173089635914 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.2159908053119969 0.0090444648829713 0.0013448670004558 0.0008184523809523 0.1151563145340026 0.000297619047619 3360 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +57334 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.1001078606097605 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0151307911035231 0.1341680150528327 0.0010607579310009 0.0050060417745554 0.1246575713479877 0.0005178663904712 1931 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +57373 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.1000336289327599 0.7941469661104034 0.773263018678637 0.6198216015396206 1.0 0.0008609682710384 0.0030576493621152 0.0013661202185792 0.4098490190825911 0.0002049180327868 4880 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +57390 VWF ITGA9 VWF-ITGA9 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0999865594944588 0.9275752708651288 0.2531744428854943 0.2461374514707439 0.1263644540569636 0.0642389143033604 0.0021295003962619 0.005428829944283 0.2540901832926344 0.001047668936616 1909 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +57427 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0998738194434965 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0075637985935472 0.166956519448744 0.0020528703109224 0.0097322311714003 0.0545965760061612 0.0029673590504451 2359 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +57481 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0997360204941261 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0255753403203798 0.0310998965832685 0.0070455657028076 0.0025863005456718 0.4880688900045677 0.0001838404265097 10879 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +57502 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0996779898415906 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0117842887908422 0.1281708518900828 0.001418704269939 0.0015213631413746 0.0314206001063352 6.405739542630197e-05 15611 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +57565 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0995243555785497 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0587727051993296 0.0501711964086628 0.0018615448900773 0.0042683763027975 0.1016643590671043 0.0005485463521667 3646 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +57579 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages B Cells Macrophages -> B Cells 0.0994877533464535 0.8978557803479422 0.7763400818577846 0.6198216015396206 0.0477973731763516 0.0467761235673353 0.0010038288124454 0.0035692116697703 0.2007166465922648 0.0009310986964618 1074 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +57623 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0993734824315234 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0561415215593491 0.0350138403862125 0.0013211655770593 0.0015299460133699 0.0654985700073466 0.0001754078231889 5701 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +57652 A2M LRP1 A2M-LRP1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.099300265317842 0.4648000335061383 0.2550748532138862 0.2461374514707439 0.2100317344087863 0.0267255153180908 0.0058530061671499 0.0032858814352574 0.285830324739479 0.0001560062402496 12820 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +57660 A2M LRP1 A2M-LRP1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0992837352573716 0.7741139100414175 0.6207977546603366 0.909150863993142 0.093381536992618 0.0104714078116759 0.0022418635460665 0.0013229747227382 0.1815898832378117 0.0001688903901368 5921 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +57675 HSPG2 LRP1 HSPG2-LRP1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0992358908301563 0.8818165186409654 0.2550748532138862 0.2461374514707439 0.1619074107723045 0.0267255153180908 0.003986528994586 0.0059586170770036 0.3561904585749926 0.00261917234154 1909 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +57731 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0990904590776088 0.7158082793127664 0.9404022517663844 0.7204611100467462 0.0071496754272206 0.1347191569099048 0.0020265234794427 0.0007395717471945 0.0320556072050839 0.0001281147908526 15611 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +57733 CD34 SELP CD34-SELP CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0990881778459993 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0298399317533219 0.0741032966028748 0.0012359682575849 0.0025580480125934 0.128611063528943 0.0003935458480913 2541 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +57833 VWF LRP1 VWF-LRP1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0988350814907756 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0036144684673052 1.0 0.00089427994968 0.0020483583885551 0.0157262932877087 9.192021325489476e-05 10879 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +57848 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0988059753134615 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0492631209980634 0.0350138403862125 0.001230766534421 0.0041982498305293 0.1797314140696825 0.0005546311702717 1803 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +57876 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0987423337965775 0.6342079770588467 0.6580560501976399 0.8824495942126559 0.002196330917593 1.0 0.0011458618652474 0.0008889653590272 0.0483289418907961 0.0001720578114246 5812 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +57924 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0985983642718297 0.6249837837987587 0.6580560501976399 0.9161861017439124 0.0084812136822336 0.1973932010691654 0.00145649566602 0.0153186274509803 0.278077979392965 0.0098039215686274 408 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +57932 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0985801440421693 0.6303682835571691 0.8891607331132086 0.6198216015396206 0.0342558468646473 0.0606680526002441 0.0012711504530151 0.005236663803798 0.1731815954582012 0.000501002004008 1996 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +58037 VWF LRP1 VWF-LRP1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0983145170266835 0.7158082793127664 0.7346293219749174 0.8293805866303694 0.0025256125075084 1.0 0.0008198101680749 0.0026020943069713 0.0199776066836498 0.0001389467833819 7197 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +58197 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0978486648807213 0.4604235282221027 0.944024288971064 0.7204611100467462 0.0839650520556947 0.0484215930647349 0.000689340998031 0.0050761421319796 0.1720081783315222 0.0016920473773265 591 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +58205 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0978248959227675 0.7324582304061453 0.7832252605020791 0.7204611100467462 1.0 0.00136079311934 0.0015581819524101 0.0026747413575574 0.3931894733630954 0.0007570022710068 1321 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +58338 A2M LRP1 A2M-LRP1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.097490319267739 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.0149044683666724 0.166956519448744 0.000906834896065 0.0075173611111111 0.0733016188911331 0.0004166666666666 2400 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +58430 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0972020448090754 0.6303682835571691 0.8891607331132086 0.6198216015396206 0.0291791383241764 0.0606680526002441 0.001371434740239 0.0061728395061728 0.2041418418747986 0.0005073566717402 1971 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +58531 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0969316866247421 0.4604235282221027 0.8817184225858201 0.2461374514707439 0.0126864732057784 1.0 0.0006543070078587 0.0066445182724252 0.0507123525177234 0.0005537098560354 1806 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +58555 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0968661384807591 0.6303642896310324 0.6331674633943454 1.0 0.141548283585814 0.0032187363284526 0.0045428601535656 0.0028648291485746 0.8334837226454928 0.0001887861053426 5297 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +58560 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0968541570330156 0.724503440376099 0.8587566561291643 0.7204611100467462 0.0027791828709671 1.0 0.0006626179854199 0.0029112891262423 0.041801486619292 0.0004450378282153 2247 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +58565 COL4A2 CD93 COL4A2-CD93 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0968400762283855 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0033449520260795 1.0 0.0005796391071653 0.0055666003976143 0.0476315240820013 0.0006626905235255 1509 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +58566 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0968382228082297 0.8730912658940219 0.9008184599638702 0.6198216015396206 0.0057086106530109 0.3180524283074206 0.0009317140462752 0.0246561556524656 0.3426370792107531 0.007380073800738 271 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +58662 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0965253192853562 0.4629984640915818 0.7346293219749174 0.8767341187813953 0.3309594876493178 0.0032275631628407 0.0025390958122739 0.0051127870634597 0.2811246933115881 0.0008153281695882 2453 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +58674 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Pericytes Pericytes -> Pericytes 0.0965005804978253 0.6303682835571691 0.773263018678637 1.0 0.0342558468646473 0.0070956399217802 0.0068160111279042 0.0031650869780366 0.3972296305506568 0.0001598721023181 12510 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +58690 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0964536660059757 0.6160088550075702 0.6632137581773894 1.0 0.0548063857429699 0.0080072638027924 0.0044911239902259 0.0033724063363481 0.8146076373884479 0.0001887861053426 5297 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +58701 VWF LRP1 VWF-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0964243520372087 0.955713094717548 0.6207977546603366 0.6198216015396206 1.0 0.0018097844702233 0.0012076556483329 0.011509324009324 1.0 0.0032051282051282 312 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +58768 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0962389778212024 0.2490567623945399 0.4638256179742202 1.0 0.011649387573427 0.5131068416842878 0.0011506357221767 0.0022582102071101 0.0513002394931199 2.580811665268727e-05 77495 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +58779 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0962022728244339 0.8730912658940219 0.8950084308969304 0.6198216015396206 0.0057086106530109 0.4247538686915498 0.0006749685363439 0.0174438108017443 0.1798192288721227 0.007380073800738 271 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +58875 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0959050742779575 0.6303682835571691 0.4614667734221426 0.2461374514707439 0.0342558468646473 0.1609352200462838 0.00197128232935 0.0069096260819676 0.1451572843923986 0.001571503404924 1909 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +58915 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0957873255324193 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0015409900107563 1.0 0.0014553913444839 0.0087800369685767 0.052349276987187 0.0018484288354898 2164 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +58924 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0957675392999135 0.7487535481622718 0.7754239189773715 0.8567148457705164 0.1027229557481577 0.0147571931436988 0.0010231038653732 0.0248484848484848 0.4976171015593839 0.0088888888888888 225 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +58945 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0957013982748978 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0070532058552773 0.166956519448744 0.0017041749716928 0.0076909722222222 0.0431453735630298 0.0025 2400 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +59005 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0954961361657118 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.00146889578236 1.0 0.0014681989873113 0.0077866666666666 0.0491888788713757 0.00096 3125 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +59055 A2M LRP1 A2M-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0953531337062584 0.8937519114898692 0.6207977546603366 0.6198216015396206 1.0 0.0018097844702233 0.0012076556483329 0.0078792735042735 1.0 0.0032051282051282 312 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +59066 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0953160533488515 0.6213271600240247 0.943345641464811 0.6198216015396206 0.2247035641022029 0.0034806998160403 0.0026391188832737 0.0028411633109619 1.0 0.0006711409395973 1490 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +59117 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0951397147046968 0.8818165186409654 0.6207977546603366 0.6198216015396206 1.0 0.0018097844702233 0.0012076556483329 0.0126869658119658 1.0 0.0032051282051282 312 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +59132 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0951119667320379 0.2451358214448441 0.663300745568453 0.2461374514707439 0.1327555461750915 0.0373075519081129 0.0037347817618131 0.0537469679560832 1.0 0.0214477211796246 373 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +59141 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.095097325050461 0.662063103571249 0.6331674633943454 0.7917001487310438 0.585843718590581 0.0023576674662702 0.001613474908638 0.0002549342105263 0.0791403589364539 3.289473684210526e-05 30400 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +59142 C1QB LRP1 C1QB-LRP1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0950967673947252 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0161519521398178 0.166956519448744 0.0009192865818874 0.0056780366056572 0.0601624794025991 0.000332778702163 3005 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +59200 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0949314937570185 0.6160088550075702 0.9546923450729716 0.909150863993142 0.0149256517769723 0.0445745465878424 0.0020575612939992 0.0077781633125144 0.2880655912037086 0.0012722646310432 1572 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +59214 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0949130876409474 0.7324582304061453 0.8617632615906476 0.7204611100467462 1.0 0.0010414441948928 0.0015435909383552 0.0037276648182378 0.4710917949166412 0.0009242144177449 1082 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +59254 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0947869446245318 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0415873844357376 0.0627790816848129 0.0006801487040676 0.0014668367346938 0.0294534947474522 0.000297619047619 3360 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +59389 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0943910587002258 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0616816618657801 0.0416128058995347 0.0009575255778316 0.0012470308788598 0.1164734770878692 0.0005938242280285 1684 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +59590 HSPG2 LRP1 HSPG2-LRP1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0938684304710833 0.8349903778527206 0.7346293219749174 0.7204611100467462 0.0014804857410621 1.0 0.0010455522180501 0.0114873519052193 0.1123256887677006 0.0019212295869356 1041 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +59597 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0938473123259618 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0037159398684439 1.0 0.0005073265814063 0.027535441657579 0.2101562471225889 0.0038167938931297 262 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +59622 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages B Cells Macrophages -> B Cells 0.0937780402666891 0.7487535481622718 0.9460955677032749 0.6198216015396206 0.0338862305197021 0.0376195773145198 0.0012151371540809 0.0080836295920094 0.2941133100742105 0.0009310986964618 1074 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +59654 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0936751973226591 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0272543760657653 0.0222186841038061 0.0043054662561695 0.0214011340771904 0.846265147918736 0.0019206145966709 1562 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +59752 COL4A2 CD93 COL4A2-CD93 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0933909719736401 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.0047240947268779 1.0 0.0004774803061216 0.0106343283582089 0.0909943648024426 0.001865671641791 536 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +59798 A2M LRP1 A2M-LRP1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.093267567938415 0.919551140852988 0.6207977546603366 0.6198216015396206 0.037376181609614 0.0501711964086628 0.0009920582934475 0.0046433511163801 0.1248037577194078 0.0005927682276229 1687 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +59799 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0932615383728902 0.2451358214448441 0.8891607331132086 0.2461374514707439 0.1327555461750915 0.0606680526002441 0.0015227723105155 0.0166297117516629 0.5499608378666968 0.0011086474501108 902 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +59953 THBS2 CD36 THBS2-CD36 Pericytes Macrophages Pericytes -> Macrophages 0.0928118993980639 0.9197297916541942 0.8587566561291643 0.8875000050982297 0.0087456089304998 0.088850508457521 0.0011734619092484 0.0035490196078431 0.0693134353115281 0.0009411764705882 2125 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +60000 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0926299782729115 0.8684504425765611 0.7779918296243433 1.0 0.0168149984327668 0.0627790816848129 0.0008856706652158 0.0020835559354631 0.0418369695479403 0.00024931438544 4011 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +60070 COL4A1 CD93 COL4A1-CD93 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0924595916432125 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0016831757123532 1.0 0.0007820464550807 0.0056802044873615 0.0433525081165429 0.001325381047051 1509 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +60146 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0922469596976731 0.6332974881236617 0.6207977546603366 0.8824495942126559 0.0131302879503246 0.166956519448744 0.0008101793868155 0.0019949008388314 0.0150311038678685 0.0004281738385784 4671 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +60150 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0922393281782088 0.7324582304061453 0.7283139964676212 0.8293805866303694 0.2376713873232418 0.0124087765732037 0.0004719825569459 0.00441400304414 0.2176086440034305 0.0045662100456621 219 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +60162 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0921945501040232 0.4629984640915818 0.7346293219749174 0.8767341187813953 0.0012814156885439 1.0 0.001607013874099 0.0057653061224489 0.0563743486317753 0.0016326530612244 2450 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +60174 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0921591540842203 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.1671376945154473 0.0064028969591119 0.0013143299802701 0.0023669972948602 0.333231189045368 0.0009017132551848 1109 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +60204 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0920685542270941 0.724503440376099 0.6176321640000088 0.6198216015396206 1.0 0.0007053434767499 0.0031133119975979 0.0010140989287964 0.4899683098388801 0.0002362948960302 4232 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +60217 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0920388092473541 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0104129581710415 0.1615013370958009 0.0009944561268243 0.0037992235163616 0.1173394069705344 0.0005546311702717 1803 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +60230 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0920197653505056 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0016171311116606 1.0 0.0010170595549793 0.003170909090909 0.0354063461768362 0.00064 3125 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +60235 C3 LRP1 C3-LRP1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0920119196870891 0.9487258305485792 0.6207977546603366 0.6198216015396206 0.0110943464444434 0.166956519448744 0.0008974217654127 0.0090472673559822 0.1272456347687624 0.000738552437223 1354 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +60266 C1QB LRP1 C1QB-LRP1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0919131949753278 0.8703788833238396 0.6207977546603366 1.0 0.0419710388788557 0.0104714078116759 0.0025389354269654 0.0006835753347161 0.068368324042997 9.428625306430322e-05 21212 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +60293 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.091843424755466 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0016417770622885 1.0 0.0008744273293044 0.0295520805724887 0.2384469049041773 0.0058309037900874 343 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +60330 CD34 SELP CD34-SELP T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0917123256619154 0.633566764858408 0.8819126042133903 0.6198216015396206 0.015517736049123 0.0741032966028748 0.0014942127626636 0.0026722925457102 0.1343549396540915 0.00028129395218 3555 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +60363 C1QB LRP1 C1QB-LRP1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.091611931198758 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0111808254589153 0.166956519448744 0.0010615007110303 0.0048016040523427 0.0508761082326749 0.0008442380751371 2369 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +60372 THBS2 CD36 THBS2-CD36 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0915956266395661 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.004981832968137 0.287457858136305 0.0012410240947401 0.0031657899863627 0.0962828156115391 0.0011689070718877 1711 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +60396 VWF LRP1 VWF-LRP1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0915366015246805 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0019871862905238 1.0 0.0010265519954587 0.0044010246348375 0.0337889133857619 0.000599520383693 3336 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +60524 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.0911326590181162 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0587727051993296 0.0144359394371152 0.0022436622270018 0.0008818948140003 0.0824119445120701 6.108362348054486e-05 16371 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +60550 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells B Cells B Cells -> B Cells 0.0910541118821299 0.7797302331085993 0.7763400818577846 1.0 0.0200499113739789 0.0467761235673353 0.0010038288124454 0.0027033380347907 0.1520237506629706 0.0007052186177715 1418 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +60600 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0908831559982589 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0637288077574987 0.0484993884807927 0.000735321116017 0.0206506691278264 0.293579829309675 0.0025380710659898 394 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +60617 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0908484216442333 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0015847932820241 1.0 0.0008485568397377 0.0246016869728209 0.1985036586409307 0.0051546391752577 388 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +60672 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0906697490506888 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.0198024073017111 0.1281708518900828 0.0006084844128575 0.0073878627968337 0.2089912316972911 0.0026385224274406 379 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +60749 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0903915168374233 0.2542249848376565 0.62431395375366 0.2461374514707439 0.1711385759005754 0.0649213179279442 0.0012566902420134 0.01859410430839 0.7661014007404571 0.0204081632653061 147 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +60775 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0903133020297769 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0548063857429699 0.0484993884807927 0.0011632941100032 0.0402443406395975 0.5721328729117559 0.0079051383399209 253 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +60812 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0901829244202256 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0342558468646473 0.0222186841038061 0.0027272148993767 0.0084926330177491 0.3358242283358705 0.0008442380751371 2369 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +60817 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0901653743799637 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.454846709299195 0.0053794918117879 0.000989072100513 0.0016675931072818 0.1357187620359247 0.0006485084306095 1542 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +60877 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0899459196078933 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0015409900107563 1.0 0.0009771218612166 0.0074707332101047 0.0471931067147525 0.0009242144177449 2164 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +60889 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0899138169643498 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.2545335314555431 0.0042738820064046 0.0025693400062393 0.0053137003841229 0.4520645931253143 0.0012804097311139 1562 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +61005 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0895094195905276 0.6626993710110988 0.6207977546603366 1.0 0.0515877972474039 0.0587195251380622 0.0004126725022428 0.000169335120694 0.0144316478201595 1.1800356842790926e-05 423716 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61043 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0893744394113351 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0561415215593491 0.0203874717835032 0.0013748216850715 0.0009196820175438 0.0287300469192952 6.578947368421052e-05 30400 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +61144 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0890258254111573 0.4629984640915818 0.8604147465201248 0.7204611100467462 0.0683610513379333 0.0436001007095475 0.0005819614854471 0.0053346493701823 0.1225940427030722 0.0016920473773265 591 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +61156 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0889962187203038 0.7468485855611411 0.7346293219749174 0.7204611100467462 0.0006689050756654 1.0 0.0018790773010939 0.0065924219150025 0.0644620569091729 0.0069124423963133 1302 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +61195 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0888587276522987 0.2534163760166434 0.6580560501976399 0.2461374514707439 0.2100740470724093 0.0606066271159369 0.0009419503646788 0.0212243074173369 0.5088802143631345 0.002680965147453 373 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +61258 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0886805221051048 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0170183763647696 0.166956519448744 0.0009668810957022 0.0060419334186939 0.064018202082721 0.0012804097311139 1562 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61336 A2M LRP1 A2M-LRP1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0884493776359141 0.8937519114898692 0.7346293219749174 0.7204611100467462 0.3743986430148447 0.0032275631628407 0.0008376398459942 0.0064509306260575 0.3809665060128749 0.0025380710659898 394 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61366 C1QB LRP1 C1QB-LRP1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.0883912279758131 0.7753420160918723 0.9078204025796472 0.946515890536252 0.0161519521398178 0.0350138403862125 0.0012658004072296 0.000856841550224 0.0301227574483123 8.788118463836892e-05 11379 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61394 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0883097694437818 0.4648000335061383 0.7346293219749174 0.8767341187813953 0.2966815529783992 0.0032275631628407 0.0016545537844314 0.0040426688408751 0.2387440684998584 0.0004076640847941 2453 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61399 VWF SELP VWF-SELP CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0883000680405904 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0016171311116606 1.0 0.0008466679805724 0.0029090909090909 0.0163577420524038 0.00096 3125 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +61406 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0882694623564081 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.141548283585814 0.0023576674662702 0.0044854079788809 0.0021259293680297 1.0 0.0009293680297397 2152 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +61477 VWF LRP1 VWF-LRP1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0880478964957284 0.9275752708651288 0.2550748532138862 0.2461374514707439 0.1263644540569636 0.0267255153180908 0.002369006869088 0.0057502738225629 0.3144597581355239 0.001047668936616 1909 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +61532 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0878623057482025 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0338862305197021 0.0484993884807927 0.0011290332905135 0.0294199665365309 0.4182483725165459 0.0061349693251533 326 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +61555 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0877932481695059 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0342558468646473 0.0218093597373452 0.0018574628584738 0.0086251093217527 0.4674406820592834 0.0006333122229259 1579 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +61599 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0876421740252748 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.1740454925211078 0.0053794918117879 0.0011937704857668 0.0004013157894736 0.0433226743697163 3.289473684210526e-05 30400 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +61633 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0875533653519457 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0967042147306326 0.0326667674102811 0.0004847819218672 0.0093873517786561 0.1987195847991918 0.0039525691699604 253 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +61652 MMP2 PECAM1 MMP2-PECAM1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0874858366405661 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0216588811659259 0.0125623889131764 0.0035192329745282 0.0006338136703398 0.2041691364878321 7.70594128072744e-05 12977 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +61658 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0874632281146619 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0411127335336962 0.0326667674102811 0.0007118618452264 0.0114451476793248 0.2287080496883604 0.0021097046413502 474 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +61771 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0871130537524247 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0338862305197021 0.0292791515533623 0.001775023607897 0.0218906860011154 0.5168910779340207 0.0122699386503067 326 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +61790 A2M LRP1 A2M-LRP1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0870393399273426 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.0015661096645571 1.0 0.0007876317519556 0.0027424353641627 0.0324720833941425 0.0002446782481037 4087 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61816 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.0869445765612794 0.6303682835571691 0.773263018678637 0.946515890536252 0.0291791383241764 0.0070956399217802 0.0045220952599592 0.0030632870073945 0.3844533735287109 8.788118463836892e-05 11379 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +61836 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0868905844289001 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.0086134406931133 0.1176565474247238 0.0008778437894708 0.0012738853503184 0.0875027986624616 0.0005307855626326 1884 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61877 C3 LRP1 C3-LRP1 Macrophages Macrophages Macrophages -> Macrophages 0.0867558374385553 0.9487258305485792 0.8604147465201248 1.0 0.0110943464444434 0.0436001007095475 0.0010798164140585 0.0035496338486574 0.1014813722467508 0.000406834825061 2458 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61917 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0866358819314705 0.8730912658940219 0.4596166826058663 0.8767341187813953 0.0057086106530109 0.1076178292491983 0.0019563464993088 0.0039888682745825 0.3341902928389073 0.0004081632653061 2450 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +61919 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.086616540761261 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.00146889578236 1.0 0.0008347241834091 0.008 0.0476984570106411 0.00032 3125 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +61955 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0864984698894771 0.6213271600240247 0.62431395375366 0.8693461273411047 0.1153131738111426 0.009460730808256 0.0011384828830165 0.0021392081736909 0.2655955977448076 0.0009578544061302 1044 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +61998 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0863569888381827 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0135527119637784 0.0501711964086628 0.0018727254403931 0.0067336468576314 0.1603822726493539 0.0008550662676357 2339 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +62031 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0862658823302668 0.7789175740361626 0.8604147465201248 0.6198216015396206 0.0492631209980634 0.0436001007095475 0.0004619014588149 0.0041812865497076 0.0960889434821679 0.0021052631578947 475 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +62039 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.0862399314581036 0.7158082793127664 0.7292496872084557 1.0 0.0071496754272206 0.2879885658616873 0.0003827400328023 0.0003773353611118 0.0139054103725243 1.0534743584341158e-05 94924 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +62052 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0861814110082668 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0110717612136884 0.0761275033764692 0.0016661958447362 0.0004751997123115 0.0457663365185551 7.70594128072744e-05 12977 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +62061 CD48 CD2 CD48-CD2 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0861506830030986 0.928447473463448 0.7763428264267787 0.6198216015396206 1.0 0.0014748371602574 0.0006204699042771 0.015015015015015 0.2473236052715263 0.003003003003003 333 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +62071 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0861243356480043 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.141548283585814 0.0049190726392343 0.0018547837105169 0.0065703380588876 0.8025748950003756 0.0010905125408942 917 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +62163 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0858486853880622 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0014378253178126 1.0 0.000649333504628 0.0045188729399255 0.0479529345228899 0.0005316321105794 1881 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +62183 C1QB LRP1 C1QB-LRP1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0857756398402978 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0161519521398178 0.0501711964086628 0.0016473699724005 0.0038289349670122 0.091197727593931 0.0014137606032045 2122 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +62225 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.085650780584547 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.1928969878996252 0.0042738820064046 0.001179781433628 0.0018746652383502 0.1594876859736382 0.0005356186395286 1867 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +62239 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0855996850912756 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0272543760657653 0.0218093597373452 0.0020057880566353 0.0116600237745612 0.6319188850467523 0.000734214390602 1362 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +62259 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0855527908714263 0.4648000335061383 0.7346293219749174 0.2461374514707439 0.0357762282281787 0.0416128058995347 0.0031337892207602 0.0026505513146734 0.1572303776276671 7.4839095943721e-05 13362 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +62267 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0854987955659481 0.7800321422220979 0.6331674633943454 1.0 0.0113788029360913 0.0518891167572028 0.0013395295966503 0.0018698578908002 0.0957018483271257 0.00024931438544 4011 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +62323 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0852803751736747 0.7487535481622718 0.9255624071030766 0.6198216015396206 0.0016417770622885 1.0 0.0005454544543404 0.0230585740789822 0.1855629317634209 0.0029154518950437 343 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +62325 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0852784315786418 0.2451358214448441 0.8445107771175474 0.2461374514707439 0.1327555461750915 0.0218093597373452 0.0026070419723576 0.0186677146787187 1.0 0.0027510316368638 727 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +62382 CCN1 CAV1 CCN1-CAV1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0851310133019347 0.7324582304061453 0.9694036398779844 0.7204611100467462 0.0025580826958339 0.5444650460041837 0.000534237450549 0.0067846607669616 0.1350823426496331 0.0022123893805309 452 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +62490 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.084739997566034 0.7941469661104034 0.663300745568453 1.0 0.0083898580598364 0.0222186841038061 0.0037708954156108 0.0048410151298578 0.1914282846025629 0.0005663583160279 5297 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +62491 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0847270549435205 0.6160088550075702 0.9460955677032749 0.909150863993142 0.0149256517769723 0.0376195773145198 0.0012434365078 0.0057830210501966 0.2104083869680816 0.0006361323155216 1572 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +62528 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0846218340437821 0.7789175740361626 0.6207977546603366 1.0 0.0075637985935472 0.0501711964086628 0.0020010396806494 0.0025173827529848 0.0427127068861017 0.0012465719272001 4011 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +62530 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0846156144928188 0.7487535481622718 0.9255624071030766 0.6198216015396206 0.0015847932820241 1.0 0.000539148410566 0.0199156513589503 0.160270389725161 0.0025773195876288 388 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +62555 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0845527131738152 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0338862305197021 0.0267210109213584 0.001311133830979 0.0025849335302806 0.2716087412971594 0.000738552437223 1354 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +62684 VWF SELP VWF-SELP Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0841504665780687 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0019871862905238 1.0 0.0005161666514796 0.0046840867081162 0.0263384969795954 0.0004621072088724 2164 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +62687 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0841356215689867 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.3309594876493178 0.0016667952436519 0.0036092928073631 0.0026025257298886 0.3292584561727912 0.0004725897920604 4232 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +62785 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0838277145783142 0.7800321422220979 0.956444566971872 0.6198216015396206 0.0014623066995027 1.0 0.0005131411232632 0.0032306163021868 0.0373295505821944 0.0006626905235255 1509 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +62798 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.083789005970414 0.6303642896310324 0.6331674633943454 0.909150863993142 0.0141923232885854 0.0518891167572028 0.0012949188286821 0.0017045454545454 0.0622342527729675 0.0001734906315058 5764 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +62819 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.083726183980182 0.893316592628645 0.9003264838243337 0.8875000050982297 0.0007691101630988 1.0 0.0006274698437465 0.004778972520908 0.0301890796824371 0.0003584229390681 2790 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +62884 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0835448241350299 0.6659645551150886 0.6614977577544194 1.0 0.1496557267835524 0.0226890201466244 0.0002273052039058 0.0001510445675877 0.0218924124121868 2.3600713685581854e-06 423716 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +62901 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0834995958517194 0.785133132759182 0.956444566971872 0.7827641335561659 0.001039571291679 1.0 0.0005546332575035 0.0157608695652173 0.1430613581655367 0.0021739130434782 460 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +62996 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0831487823859372 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0291791383241764 0.0222186841038061 0.0019668464040573 0.0069645828381269 0.275400532721373 0.000332778702163 3005 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +63036 MMRN2 CD93 MMRN2-CD93 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0830262299344455 0.9468422434493456 0.6587114738285964 0.6198216015396206 0.1120119983652299 0.0042738820064046 0.001769953044924 0.0022161249472351 0.2828959888213387 0.0004221190375685 2369 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +63069 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0829038712794367 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0637288077574987 0.0292791515533623 0.0007011926410139 0.0113059529303184 0.2669603957101117 0.0025380710659898 394 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +63100 C3 LRP1 C3-LRP1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0828222346024488 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0091898156146168 0.166956519448744 0.0006135024473669 0.0024166314900802 0.0339888052223973 0.0004221190375685 2369 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +63175 COL4A2 CD93 COL4A2-CD93 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0825524888862976 0.8840293712888387 0.6587114738285964 0.6198216015396206 1.0 0.0007261054236978 0.0012076556483329 0.0073717948717948 1.0 0.0032051282051282 312 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +63227 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0823604123134928 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0272543760657653 0.0373075519081129 0.0011844113663492 0.0241346918129922 0.4553948118354567 0.0015174506828528 659 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +63228 C3 LRP1 C3-LRP1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0823579621129394 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0064915662046245 0.166956519448744 0.0008397058996089 0.0035690515806988 0.0501970612826187 0.000332778702163 3005 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +63238 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0823311979702856 0.662063103571249 0.6331674633943454 1.0 0.0967042147306326 0.0032187363284526 0.0023869020488068 0.0011681140268076 0.2300952120358828 0.0001887861053426 5297 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +63263 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0822485315816519 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0342558468646473 0.0373075519081129 0.0009346758047345 0.0124431682220626 0.2347887553332146 0.0050251256281407 398 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +63277 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0822077383619381 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.7696906278989153 0.001079730675535 0.0016633795019053 0.0008270321361058 0.139863821952477 0.0002362948960302 4232 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +63342 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0819583253252623 0.8640667164982425 0.6331674633943454 0.6198216015396206 1.0 0.0007400708115376 0.0012076556483329 0.0054086538461538 1.0 0.0032051282051282 312 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +63387 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0818377534649388 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0083518627398662 0.1176565474247238 0.0010899648234454 0.0026203966005665 0.179994248381813 0.0007082152974504 1412 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +63455 A2M LRP1 A2M-LRP1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0816318296861057 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.0149044683666724 0.0350138403862125 0.0013017442274901 0.0017463666197843 0.1019717977813827 0.00028129395218 3555 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +63500 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0814653802788436 0.718867305289982 0.8537710813834968 0.7204611100467462 1.0 0.0004138063814779 0.0015974504665198 0.0034658040665434 0.5045403456334232 0.0009242144177449 1082 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +63503 VWF SELP VWF-SELP Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0814574765770548 0.9275752708651288 0.7760344326192508 0.6198216015396206 0.1263644540569636 0.0032078747392388 0.0016152599724197 0.0021302320225689 0.3534850836084024 0.0006333122229259 1579 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +63515 A2M LRP1 A2M-LRP1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0814385327638824 0.919551140852988 0.6207977546603366 0.6198216015396206 0.037376181609614 0.0104714078116759 0.0021066107427347 0.0019341909023117 0.2654846642749533 0.0002796420581655 3576 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +63541 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0813249591024501 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0548063857429699 0.0292791515533623 0.0010264409242747 0.0377290693496227 0.8908729184905481 0.0039525691699604 253 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +63655 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0808901065728149 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.002196330917593 0.1993723722552783 0.001845528535088 0.0031466666666666 0.1165815625377906 0.00064 3125 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +63760 C3 LRP1 C3-LRP1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0805941554954131 0.8911088195487638 0.8604147465201248 0.8875000050982297 0.0064915662046245 0.0436001007095475 0.0014228971955634 0.0029303675048355 0.0837770114487944 0.0007736943907156 2585 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +63777 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0805355660552892 0.724503440376099 0.8587566561291643 0.7204611100467462 0.0027791828709671 0.287457858136305 0.0007619150941115 0.0021146210944243 0.0643130699761449 0.0005178663904712 1931 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +63853 C3 LRP1 C3-LRP1 Pericytes Macrophages Pericytes -> Macrophages 0.0802907282070991 0.8911088195487638 0.8604147465201248 0.8875000050982297 0.0091898156146168 0.0436001007095475 0.0009826212066101 0.0034 0.0972034526235583 0.0004705882352941 2125 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +63962 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0798620070801111 0.7158082793127664 0.8794572885381431 0.7204611100467462 0.0071496754272206 0.104965956217838 0.0007622161638456 0.000552336110105 0.0123791537236778 9.9601593625498e-05 10040 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +64067 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0794339426566411 0.250044481781731 0.8817184225858201 0.2461374514707439 0.0070431301838115 1.0 0.0006572624792791 0.0085825027685492 0.0511715174186695 0.0005537098560354 1806 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +64091 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0793540854802606 0.7158082793127664 0.8604147465201248 0.7204611100467462 0.0071496754272206 0.0436001007095475 0.0018051932105855 0.0009099963781238 0.0173588935081832 0.0003984063745019 10040 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +64109 C3 LRP1 C3-LRP1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.0792713091476954 0.8911088195487638 0.9078204025796472 0.946515890536252 0.0091898156146168 0.0144359394371152 0.0024427733763838 0.0006750045150803 0.115273690392533 9.030160736861116e-05 11074 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +64120 C3 LRP1 C3-LRP1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.07920893039904 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0691889863216023 0.0064028969591119 0.0015676504794898 0.0030097613882863 0.5702114296841384 0.0010845986984815 922 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +64136 C3 LRP1 C3-LRP1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0791522584596596 0.7148920381722296 0.7346293219749174 1.0 0.005043231651446 0.0416128058995347 0.0022311681494376 0.0005959035821296 0.0556577735133626 8.944143821832655e-05 22361 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +64166 CD48 CD2 CD48-CD2 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0790534640039841 0.9011089648206808 0.4603649459881741 0.6198216015396206 0.4567172527116189 0.0062523288579129 0.0003324115786215 0.00836820083682 0.0989060242532596 0.00418410041841 239 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +64174 C3 LRP1 C3-LRP1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0790128497998606 0.7796725988275006 0.7346293219749174 0.7204611100467462 0.000819605673545 1.0 0.000719414139979 0.004800307219662 0.0850384459543983 0.0007680491551459 1302 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +64198 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0789125276861771 0.724503440376099 0.8765901449012573 0.7204611100467462 1.0 0.0004295051170816 0.0012287007966367 0.0024645717806531 0.2984924695229146 0.0009242144177449 1082 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +64200 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0789039076858429 0.4619393085577573 0.6331674633943454 0.2461374514707439 0.0835287751665837 0.0518891167572028 0.0007733777732135 0.0034387895460797 0.1760018861256768 0.0013755158184319 727 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +64277 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0786239469464849 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0117842887908422 0.0627790816848129 0.0009189600330566 0.0022627537026878 0.0495501465361079 0.0002742731760833 3646 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +64295 MMP2 PECAM1 MMP2-PECAM1 B Cells Pericytes B Cells -> Pericytes 0.0785762092255627 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0024819960935566 0.1615013370958009 0.0016153978295265 0.0049752270850536 0.1536603974969637 0.0024772914946325 1211 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +64345 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0783916033371401 0.4619393085577573 0.7167436199046466 0.8293805866303694 0.0308750930304183 0.0125623889131764 0.0021788716689355 0.000303946088648 0.1411172684274953 0.0001389467833819 7197 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +64382 C3 LRP1 C3-LRP1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0782490680100823 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0091898156146168 0.0501711964086628 0.001451986671082 0.0033090563647878 0.0952116814047059 0.0018999366687777 1579 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +64434 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0780169364456813 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.1496557267835524 0.0024832440877005 0.0018934120923509 0.0005262234695667 0.1345264283715099 0.0001754078231889 5701 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +64490 MMP2 PECAM1 MMP2-PECAM1 Macrophages Macrophages Macrophages -> Macrophages 0.0777815262405692 0.9330801352629944 0.9015117569158254 1.0 0.0088108219576754 0.0246995741084876 0.0012096459131897 0.0025020341741253 0.1273511897416606 0.000406834825061 2458 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +64495 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0777601444808254 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0071496754272206 0.0350138403862125 0.0018862794308214 0.0006798819014564 0.0277723599863942 0.0001281147908526 15611 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +64512 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.077690241540877 0.9197297916541942 0.8587566561291643 0.8875000050982297 0.0055862851962672 0.088850508457521 0.0006319887698928 0.0030723314606741 0.0600035704182627 0.0007022471910112 1424 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +64592 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0773516884727703 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0213929720256037 0.0125623889131764 0.0023000111070409 0.0002240555198088 0.1040253653934439 9.192021325489476e-05 10879 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +64599 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0773001254846182 0.7741139100414175 0.2550748532138862 0.2461374514707439 0.1671376945154473 0.0267255153180908 0.0009827110374758 0.0027080957810718 0.2355702455431838 0.0011402508551881 877 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +64602 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0772907501205068 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0587727051993296 0.0064028969591119 0.0018825483853468 0.0006427015250544 0.0660705558401514 8.714596949891067e-05 11475 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +64682 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0769903277561482 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0070532058552773 0.0350138403862125 0.0019241084203931 0.0013009845288326 0.0556964922262342 0.0011251758087201 3555 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +64733 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0767511331289061 0.9470274865242416 0.4638256179742202 0.7204611100467462 0.0061455194924501 0.0689186266365139 0.0015250429132699 0.0003725329197457 0.0453923128172188 9.123255177447311e-05 10961 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +64837 C3 LRP1 C3-LRP1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.076319857331825 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0042375227960614 0.166956519448744 0.0008992513733576 0.0063533057851239 0.0893563101098802 0.0020661157024793 968 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +64842 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0763006284030199 0.2491408586098361 0.956444566971872 0.2461374514707439 0.0049987108499989 1.0 0.0006730089600533 0.0059108527131782 0.0536527894964576 0.0005537098560354 1806 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +64878 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0761457084526579 0.8560892486218385 0.956444566971872 0.8567148457705164 0.0006966068981631 1.0 0.0003988894391343 0.0135869565217391 0.1233287570392557 0.0036231884057971 276 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65047 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0754911792608211 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0255753403203798 0.0091569531245039 0.002668084687783 0.0016366193581383 0.4283788058962071 0.00028129395218 3555 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +65123 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0751186698492783 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0016171311116606 1.0 0.0003852879164345 0.0031265031265031 0.0240037609663656 0.000755857898715 1323 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65133 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0750956712163289 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0106922602624424 0.0125623889131764 0.0028515234330008 0.0004926557795821 0.1586982260087533 9.123255177447311e-05 10961 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65140 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0750629078361801 0.6213271600240247 0.252518874138558 0.2461374514707439 0.1153131738111426 0.0322196586137726 0.0012466853790867 0.0021664766248574 0.3791250661688758 0.0011402508551881 877 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +65191 C1QB LRP1 C1QB-LRP1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0748629183328692 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0111808254589153 0.0501711964086628 0.0010518587020356 0.0062935402153261 0.1498997948786337 0.0006333122229259 1579 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +65195 THBS2 CD36 THBS2-CD36 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0748535587245841 0.8858959974474152 0.7373999388878224 0.7204611100467462 0.0030563796158022 0.0455125113141721 0.0026868108410222 0.0006962955368737 0.1583287535607889 0.000102522042239 9754 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65235 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.074683828634171 0.8023917560710954 0.4596166826058663 1.0 0.0085367158000785 0.0292373734098458 0.0018851462250718 0.0005203865496339 0.0794659916185153 4.472071910916328e-05 22361 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +65244 C1QB LRP1 C1QB-LRP1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0746490636075409 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0012213774841743 1.0 0.0003452295786512 0.0033021133525456 0.0244925287799869 0.0009606147934678 1041 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +65289 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0744291918521136 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0071496754272206 0.166956519448744 0.0005170678039301 0.0022686518502418 0.0170937527005057 0.0011954572624028 1673 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65290 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0744268632173073 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.1671376945154473 0.0018097844702233 0.0014769163894192 0.0029736314130123 0.4012365294053204 0.0008598452278589 1163 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +65345 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0741783291103649 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0039530346951707 1.0 0.0001396522406669 0.0073051948051948 0.0541842980259026 0.0129870129870129 77 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +65382 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0739789569372404 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0170183763647696 0.0501711964086628 0.0010844316750809 0.0077551395007342 0.1847122256539047 0.000734214390602 1362 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +65397 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0739052045004402 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.1836996873148393 0.0032275631628407 0.000915912839993 0.0129007465963987 0.7093427489524635 0.0039525691699604 253 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65410 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0738372221186563 0.4619393085577573 0.930308383061206 0.7204611100467462 0.0051428381563772 0.1615013370958009 0.0006301485427867 0.0049778761061946 0.1879385180110547 0.0022123893805309 452 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +65457 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0735704174789289 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0075637985935472 0.0587195251380622 0.0009325865386476 0.0006689198704407 0.0471628061451745 0.000253485424588 3945 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65552 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.073151932538433 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.0037268694422441 0.166956519448744 0.0007160876072991 0.0039556962025316 0.0385719045821146 0.0014064697609001 1422 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +65572 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0730828858381347 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.0683610513379333 0.0064028969591119 0.001149514119976 0.001553243750903 0.1837979423999936 0.0006501950585175 1538 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65577 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0730732062157557 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0548063857429699 0.0147571931436988 0.0006357904124208 0.0332167832167832 0.6652010973003019 0.0076923076923076 130 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +65594 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0729840274386819 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.0839650520556947 0.0042738820064046 0.0022403887704484 0.0047558075727089 0.3437194508654079 0.0012804097311139 1562 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +65691 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Mast Cells Pericytes -> Mast Cells 0.0726021238917819 0.7487535481622718 0.7757991160529997 0.8567148457705164 0.0637288077574987 0.0044430418127202 0.0010393218379868 0.0137373737373737 0.513518331639883 0.0088888888888888 225 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +65696 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0725885434940733 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0213929720256037 0.0326667674102811 0.0006040607584111 0.0051718092566619 0.1094813332212865 0.0014025245441795 713 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +65727 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0724314296122291 0.7835752212271604 0.4638256179742202 0.2461374514707439 0.0064863313435223 0.5131068416842878 0.000484989813188 0.0170765027322404 0.4124523314429573 0.0081967213114754 122 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +65783 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0721849793693752 0.6589792304505506 0.2550748532138862 0.2461374514707439 0.1836996873148393 0.0267255153180908 0.0006965029826961 0.0112007168458781 0.6695493968053683 0.0064516129032258 155 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65785 THBS2 CD36 THBS2-CD36 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0721810733894801 0.9197297916541942 0.8587566561291643 0.8875000050982297 0.0039472834455595 0.088850508457521 0.0005752734592683 0.0014023210831721 0.0273877584304236 0.0003868471953578 2585 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +65906 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0716130875152294 0.6605327397359113 0.657421674383923 1.0 0.0227314494836465 0.0069492509109592 0.0019662913022356 0.0009124661758227 0.1561471649561513 0.0001887861053426 5297 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +66037 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0709028066117688 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0255753403203798 0.0292791515533623 0.0009660081351595 0.0118577075098814 0.2799886315256007 0.0014025245441795 713 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +66057 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.07077820688061 0.4629984640915818 0.7346293219749174 0.2461374514707439 0.0201301851612071 0.0416128058995347 0.0017926449439705 0.0015581084002727 0.0514500088532598 7.4839095943721e-05 13362 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66071 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0706891182492107 0.7487535481622718 0.7462743270426613 0.7827641335561659 0.1027229557481577 0.0022591041672132 0.0012292431449087 0.0073834794646977 0.820441704860675 0.0025380710659898 394 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +66075 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0706734096101437 0.6589792304505506 0.6207977546603366 0.8824495942126559 0.0033973231723341 0.0587195251380622 0.0017302195547503 0.0003756548111386 0.0264858854074125 0.0001654259718775 12090 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66078 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0706607646254943 0.4601010570874773 0.6207977546603366 0.2461374514707439 0.0177188549930425 0.0501711964086628 0.0019915731836023 0.0163342503438789 0.3890498339998002 0.0041265474552957 727 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +66125 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0704119693914956 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0131302879503246 0.0350138403862125 0.0007438480466385 0.0005082840331042 0.0207627929386967 0.0001754078231889 5701 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66179 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0701371398088174 0.7789175740361626 0.8604147465201248 0.6198216015396206 0.0070532058552773 0.0436001007095475 0.0009318431294323 0.0011745616584326 0.0269922636183225 0.000581226387678 3441 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66230 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0699009574177864 0.7789175740361626 0.8604147465201248 0.6198216015396206 0.0075637985935472 0.0436001007095475 0.0008515290131777 0.0020667483159828 0.0474953485644818 0.0012247397428046 1633 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66281 CD48 CD2 CD48-CD2 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0696088767803916 0.9426443637490616 0.6614977577544194 0.7917001487310438 0.0632786830726401 0.0024251058581756 0.0015016125056751 0.003099173553719 0.4983205025309834 0.0010330578512396 968 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +66333 CD34 SELP CD34-SELP B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0692922185396706 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0006336851232098 1.0 0.0005043513120649 0.0029821073558648 0.036061636410219 0.0006626905235255 1509 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +66419 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0689257733503222 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0075637985935472 0.0350138403862125 0.0009237333330904 0.0024920449379829 0.1066870192840332 0.0005844535359438 1711 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66458 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0687278692146164 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0048525806497539 0.0501711964086628 0.0012624611724456 0.0044532130777903 0.1281325725671115 0.0033821871476888 887 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +66468 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0686832594864388 0.4648000335061383 0.2550748532138862 1.0 0.0357762282281787 0.0267255153180908 0.000926074535613 0.0007640277867389 0.0664608004568689 1.2904058326343637e-05 77495 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +66494 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0685599169521101 0.2486570577556728 0.9404022517663844 0.2461374514707439 0.0033537993821664 1.0 0.0005380009653518 0.0030705728380146 0.0342859923596137 0.0005537098560354 1806 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +66587 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0680968792630829 0.4619393085577573 0.2491073778594529 1.0 0.0835287751665837 0.0076066460958003 0.0013638248036779 0.000345990063875 0.1441421022818866 1.2904058326343637e-05 77495 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +66613 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0679349715720033 0.2486570577556728 0.7346293219749174 0.2461374514707439 0.0033537993821664 1.0 0.0006518813501257 0.0024269131155788 0.0186326512257954 0.0002049600327936 4879 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66622 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0678672588241523 0.6626993710110988 0.6207977546603366 0.8824495942126559 0.0039530346951707 0.0587195251380622 0.001159543775053 0.0002791563275434 0.0237912004867243 8.271298593879239e-05 12090 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +66627 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0678477960019015 0.6332974881236617 0.6207977546603366 1.0 0.0016171311116606 0.166956519448744 0.0009189682204463 0.0022632879674601 0.0170533371181084 0.0003775722106852 5297 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66717 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.0672660232516145 0.7205550478301406 0.7154802332407408 1.0 0.0117842887908422 0.0292771742399634 0.0005207967998534 0.0002247411964659 0.0257461707127549 1.0534743584341158e-05 94924 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +66740 C3 LRP1 C3-LRP1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0671561663686765 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.0029337538459309 0.166956519448744 0.0006808055892302 0.0123684210526315 0.1739561268617507 0.0070175438596491 285 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +66751 CD48 CD2 CD48-CD2 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0671170912204489 0.9011089648206808 0.7763428264267787 0.6198216015396206 0.4567172527116189 0.0002517784065132 0.0018332245007075 0.0021691973969631 0.7797739899749272 0.0010845986984815 922 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +66757 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0671024617873686 0.6332974881236617 0.8604147465201248 0.6198216015396206 0.0131302879503246 0.0436001007095475 0.0004721467578665 0.0009252405625462 0.017649688263381 0.001480384900074 1351 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66794 MMP2 PECAM1 MMP2-PECAM1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0668899495660643 0.9330801352629944 0.6331674633943454 0.6198216015396206 0.0088108219576754 0.0176963220730796 0.0015687654114644 0.001111577181208 0.1472267959133613 0.0002796420581655 3576 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66832 VWF SELP VWF-SELP T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0666688905006466 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0036144684673052 0.0741032966028748 0.0009470033369824 0.0023398542385884 0.0539674345810273 0.00028129395218 3555 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +66866 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0665145886351113 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.0026436039558049 0.166956519448744 0.0005782257228361 0.0044831223628691 0.0251497448548678 0.0014064697609001 1422 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66870 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.066496021686372 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0015847932820241 0.3180524283074206 0.0004102479366872 0.0152406417112299 0.2117933158290717 0.0058823529411764 170 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +66890 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0663524194639308 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0141923232885854 0.0326667674102811 0.0006572819609647 0.0064866760168302 0.1296230561925809 0.0014025245441795 713 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +66897 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0663253329368421 0.7797302331085993 0.657421674383923 0.7917001487310438 0.0200499113739789 0.0069492509109592 0.0015054742092776 0.002926997245179 0.5008868643893015 0.0010330578512396 968 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +66975 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0659396279572721 0.7941469661104034 0.663300745568453 0.9161861017439124 0.0083898580598364 0.0373075519081129 0.0005441565881592 0.0063824008690928 0.12042881116362 0.0019011406844106 526 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +67023 THBS2 CD36 THBS2-CD36 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0655873015964287 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.004981832968137 0.088850508457521 0.0005412028490918 0.0019646866707491 0.0383709298645302 0.0006123698714023 1633 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +67026 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0655760625120128 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0548063857429699 0.0044430418127202 0.0011024337338174 0.0293706293706293 1.0 0.0153846153846153 130 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +67083 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0652554718088417 0.4625081978296446 0.4642836810638544 0.2461374514707439 0.0141498126994191 0.0917308979735958 0.0011255128698497 0.019680196801968 1.0 0.003690036900369 271 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +67131 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0649333679876301 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0170183763647696 0.0203874717835032 0.0012202588149928 0.0008181818181818 0.0463339755206872 0.0001454545454545 6875 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +67173 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells B Cells Plasma Cells -> B Cells 0.0647399879759365 0.8730912658940219 0.9460955677032749 0.6198216015396206 0.0057086106530109 0.0376195773145198 0.000669611052171 0.0083694083694083 0.3045110331778063 0.0031746031746031 315 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +67182 CCN1 CAV1 CCN1-CAV1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0646925926019497 0.8619922139338987 0.62431395375366 0.6198216015396206 0.0054092055025683 0.0649213179279442 0.0006257856597736 0.0015017232890201 0.0618729623197722 0.000738552437223 1354 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +67193 C3 LRP1 C3-LRP1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0646445047466161 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0064915662046245 0.0501711964086628 0.0006534776215995 0.0014962299717247 0.0430511165938288 0.0004712535344015 2122 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +67250 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0642228757541705 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0149256517769723 0.0484993884807927 0.0005523459946624 0.0192088246481551 0.2730818757754425 0.00418410041841 239 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +67352 HSPG2 LRP1 HSPG2-LRP1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0635618921061244 0.9253089325030373 0.6207977546603366 0.6198216015396206 0.0022161183602947 0.166956519448744 0.0005005763026747 0.0035286394222878 0.0197952172553621 0.001477104874446 1354 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +67382 THBS2 CD36 THBS2-CD36 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0632903794386348 0.6242573126045354 0.6176321640000088 1.0 0.004981832968137 0.0284069116891947 0.0011779171364943 0.0008933765478268 0.0740022932335122 0.00024931438544 4011 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +67386 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0632519729030066 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.0208904415011529 0.0118035014556376 0.0006690782431419 0.0015114873035066 0.1158021616454686 0.0012091898428053 827 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +67388 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0632475303967251 0.4629984640915818 0.2550748532138862 1.0 0.0201301851612071 0.0267255153180908 0.0010074782094018 0.0006579277516112 0.0393291907379039 2.580811665268727e-05 77495 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +67395 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0631308615795658 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0101610580570933 0.0222186841038061 0.0010819740053543 0.0037856146642757 0.1496945789074382 0.0005977286312014 1673 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +67403 THBS2 CD36 THBS2-CD36 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.063055023641103 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0087456089304998 0.0284069116891947 0.0007185227171426 0.0008444162972345 0.0699467011878858 0.0006333122229259 1579 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +67404 C3 LRP1 C3-LRP1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0630381061422948 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0691889863216023 0.0032275631628407 0.0009764598412567 0.009205020920502 0.8534522600756552 0.00418410041841 239 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +67446 CD48 CD2 CD48-CD2 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.062772908492207 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0076331962782219 0.0229905310518441 0.0008131182984161 0.0018999366687777 0.0895764195262239 0.0006333122229259 1579 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +67455 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0627098128011845 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0616816618657801 0.0032275631628407 0.0010615237624469 0.0102766798418972 0.9528121351257854 0.0039525691699604 253 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +67556 A2M LRP1 A2M-LRP1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0620107095002589 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.0015661096645571 0.166956519448744 0.0005715424592902 0.0037017906336088 0.0360960770979182 0.0020661157024793 968 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +67595 VWF SELP VWF-SELP Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0616747480373342 0.8525936146535493 0.8819126042133903 0.8567148457705164 0.0002103933337194 1.0 0.0004060476991008 0.0075757575757575 0.0425982865948016 0.0108695652173913 276 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +67646 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0613120673522344 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0131092554497256 0.0292791515533623 0.0005577250568737 0.0098883572567783 0.233487595646495 0.0035087719298245 285 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +67676 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0610862992183475 0.6589792304505506 0.6207977546603366 0.9161861017439124 0.0033973231723341 0.166956519448744 0.0002443981933236 0.0055827886710239 0.0313187326354928 0.0024509803921568 408 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +67715 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0607867193777915 0.2486570577556728 0.8819126042133903 0.2461374514707439 0.0033537993821664 1.0 0.0002786725483018 0.0016359609382865 0.0091989655437279 0.0005537098560354 1806 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +67801 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0601520204914581 0.2490567623945399 0.4641352222874551 1.0 0.011649387573427 0.0455121851821151 0.0007728968767733 0.0006322988579908 0.0462931557668547 1.2904058326343637e-05 77495 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +67827 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0599560988772452 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0149256517769723 0.0292791515533623 0.0006051816369798 0.0138836059338151 0.3278249039968505 0.00418410041841 239 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +67906 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Pericytes B Cells -> Pericytes 0.0592373047000765 0.7800321422220979 0.930308383061206 0.6198216015396206 0.0014623066995027 0.1615013370958009 0.0004067591353083 0.0007741535920726 0.0292279831203539 0.0008257638315441 1211 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +68088 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0577926972396003 0.7789175740361626 0.6207977546603366 0.909150863993142 0.0075637985935472 0.0104714078116759 0.0010700648364631 0.0004949426710953 0.0413707586341495 0.0001688903901368 5921 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68124 VWF ITGA9 VWF-ITGA9 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.057434828332817 0.8525936146535493 0.9404022517663844 0.8567148457705164 0.0002103933337194 1.0 0.0002483646678811 0.0042819499341238 0.0478122195663465 0.0036231884057971 276 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +68146 VWF LRP1 VWF-LRP1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0572035875379868 0.6332974881236617 0.6207977546603366 1.0 0.0019871862905238 0.0501711964086628 0.0008938847079515 0.001051086784071 0.0213082958426291 0.00049862877088 4011 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68156 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes B Cells Pericytes -> B Cells 0.0571573781333371 0.9468422434493456 0.6347970925105053 0.6198216015396206 0.1120119983652299 0.000671064546954 0.0012451328018112 0.0009407337723424 0.312008513423731 0.0009407337723424 1063 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +68220 C3 LRP1 C3-LRP1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0566183774823916 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0334108479684367 0.0032275631628407 0.0010615237624469 0.0036465638148667 0.3380946285930207 0.0014025245441795 713 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +68258 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0560586480475504 0.6242573126045354 0.8765901449012573 0.6198216015396206 0.1932385901170197 0.0004295051170816 0.0011024337338174 0.0096153846153846 1.0 0.0153846153846153 130 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68260 COL4A1 CD93 COL4A1-CD93 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0560452098159296 0.8684504425765611 0.7779918296243433 0.909150863993142 0.0016831757123532 0.0627790816848129 0.0004774399852705 0.0015678317808724 0.0314814348663368 0.0006455777921239 1549 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +68269 VWF LRP1 VWF-LRP1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0559886434269517 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0036144684673052 0.0350138403862125 0.0006830199148617 0.0006872522695307 0.0280734306796333 0.00028129395218 3555 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68272 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0559216154039312 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0492631209980634 0.0018097844702233 0.0008960242242001 0.001659978981561 0.1476821980192405 0.0008598452278589 1163 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68342 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0551764993751685 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.002676946692949 0.0518891167572028 0.0005990558471965 0.0016910935738444 0.0865524495242618 0.0011273957158962 887 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +68349 VWF SELP VWF-SELP Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0551380429639625 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0019871862905238 0.0741032966028748 0.0005512159923755 0.0016470963285691 0.0379893592920263 0.0005844535359438 1711 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +68350 VWF LRP1 VWF-LRP1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0551369369817879 0.6332974881236617 0.8604147465201248 0.6198216015396206 0.0036144684673052 0.0436001007095475 0.0005278761229728 0.0009081662307468 0.0173239820138242 0.000290613193839 3441 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68402 C3 LRP1 C3-LRP1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0546426399041304 0.7148920381722296 0.8604147465201248 0.7204611100467462 0.0029337538459309 0.0436001007095475 0.0004695795541006 0.0048961424332344 0.1399770438373809 0.0029673590504451 337 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +68431 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0543490837666306 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0587727051993296 0.0016667952436519 0.0014860031389734 0.0006350425330812 0.1116251755053745 0.0002362948960302 4232 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +68438 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.054300728164804 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0003521782369754 1.0 0.0002102511465092 0.0064191533657182 0.0360947313894884 0.0038167938931297 262 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +68479 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0538448390055508 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0255753403203798 0.0044430418127202 0.0007240233394864 0.009009009009009 0.3367667914172523 0.003003003003003 333 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +68494 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0536423224299421 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0006856224272495 0.12709315903692 0.0011076454898924 0.0005121269024201 0.0241257570631692 9.192021325489476e-05 10879 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +68529 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.053289490678886 0.9097736029185508 0.773263018678637 0.6198216015396206 0.0430965463818576 0.0008609682710384 0.0014154166187514 0.0012881617931212 0.3864607522458544 0.0009017132551848 1109 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +68557 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0530417121753182 0.4604235282221027 0.7779918296243433 0.2461374514707439 0.0126864732057784 0.0627790816848129 0.0003171209684307 0.0014737669483199 0.0295926506642663 0.0013755158184319 727 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +68567 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0529635052972602 0.2451358214448441 0.663300745568453 0.2461374514707439 0.0010709508378277 1.0 0.0005149716117553 0.0179865424430641 0.3083309455956218 0.0054347826086956 184 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +68601 C3 LRP1 C3-LRP1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.052579863227641 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.0029337538459309 0.0501711964086628 0.0005218808591557 0.0074723247232472 0.215001656808568 0.003690036900369 271 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +68656 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0518815725103059 0.8937519114898692 0.9078204025796472 1.0 0.0037268694422441 0.0064028969591119 0.0010072447251562 0.0003835945923529 0.0540033072275681 0.0002488181139586 4019 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +68694 VWF LRP1 VWF-LRP1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0513981490442723 0.6332974881236617 0.6207977546603366 1.0 0.0036144684673052 0.0104714078116759 0.00123900289167 0.0001939296795981 0.0162815693240009 9.428625306430322e-05 21212 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68697 THBS2 CD36 THBS2-CD36 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0513450280892204 0.8858959974474152 0.6176321640000088 0.6198216015396206 0.0030563796158022 0.0284069116891947 0.0006222589262417 0.0005927682276229 0.0491015891415256 0.0005927682276229 1687 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68712 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0512070658703062 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0106922602624424 0.0049190726392343 0.0009632553507102 0.0020543615676359 0.250942798477149 0.0012642225031605 791 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +68745 MMRN2 CD93 MMRN2-CD93 Mast Cells Pericytes Mast Cells -> Pericytes 0.0507634139617694 0.8571898293845529 0.8817184225858201 0.8567148457705164 0.0004196880356983 0.1281708518900828 0.0004912772087328 0.0102459016393442 0.2116078465314927 0.0040983606557377 244 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +68764 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0504739896572889 0.8630183004227985 0.4614667734221426 0.2461374514707439 0.0016575843792215 0.1609352200462838 0.0006323119278532 0.0054141337386018 0.1137400116170843 0.0013297872340425 752 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +68835 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells B Cells Mast Cells -> B Cells 0.0493138670359652 0.7487535481622718 0.9546923450729716 0.6198216015396206 0.0016417770622885 0.0445745465878424 0.0004435388315588 0.0101461038961038 0.3757626704164146 0.0089285714285714 112 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +68886 C3 LRP1 C3-LRP1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0485533426424702 0.9487258305485792 0.7346293219749174 0.7204611100467462 0.0110943464444434 0.0032275631628407 0.0007286367817695 0.0037576687116564 0.3483958246565115 0.0030674846625766 326 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +68985 VWF LRP1 VWF-LRP1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0468540574762842 0.6332974881236617 0.8604147465201248 0.6198216015396206 0.0019871862905238 0.0436001007095475 0.0003615434738371 0.0008976785614875 0.0171239215100694 0.0006123698714023 1633 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +69089 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.044837651285691 0.6342079770588467 0.6580560501976399 1.0 0.000895875398841 0.0362497659817488 0.0005995114693646 0.0009931383170819 0.0416515967968747 0.0005417118093174 1846 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +69110 C3 LRP1 C3-LRP1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.044270052331901 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.0029337538459309 0.0104714078116759 0.0008907736678136 0.0022908366533864 0.2254281384172232 0.0013280212483399 753 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +69237 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.042024646765068 0.7789175740361626 0.2550748532138862 0.2461374514707439 0.0075637985935472 0.0267255153180908 0.0005572023861569 0.0014775413711583 0.0883235374509209 0.0013297872340425 752 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +69285 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0416328876765398 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0014623066995027 0.0326667674102811 0.0003145680492152 0.0033670033670033 0.0712756405517569 0.0033670033670033 297 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +69392 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0410138515119064 0.8560892486218385 0.6331674633943454 0.6198216015396206 0.0006966068981631 0.0518891167572028 0.0003919200852731 0.0055555555555555 0.2028375645933754 0.0061728395061728 162 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +69397 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0409694354854225 0.8667347161816407 0.4603649459881741 0.6198216015396206 0.0106228227237899 0.0062523288579129 0.0002878768715983 0.0189873417721519 0.2244165170556555 0.0126582278481012 79 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +69885 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0400517558708416 0.2451358214448441 0.8891607331132086 0.2461374514707439 0.0010709508378277 0.0606680526002441 0.0011842058012268 0.0132623224728487 0.438597979817472 0.0014619883040935 684 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +69892 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.040039944271527 0.2485046029682279 0.2550748532138862 1.0 0.0036991419150414 0.0267255153180908 0.0006575422177059 0.000211626556552 0.0335058752162514 1.2904058326343637e-05 77495 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +70810 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0379973579770555 0.2451358214448441 0.4614667734221426 0.3990376746076917 0.0010709508378277 0.1609352200462838 0.0003868328132361 0.0171214553237025 0.3596871856959747 0.0112359550561797 89 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +70915 CCN1 CAV1 CCN1-CAV1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0379166627630708 0.7324582304061453 0.252518874138558 0.2461374514707439 0.0025580826958339 0.0322196586137726 0.0007919237291808 0.0028290282902829 0.4950690561074898 0.003690036900369 271 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +70972 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0378505776382156 0.4593282471594782 0.4603649459881741 0.2461374514707439 0.0181222899145132 0.0062523288579129 0.0004986173679323 0.0165441176470588 0.1955393916992293 0.0036764705882352 272 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +71892 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0357623738049672 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.7029371915698084 1.0 0.0 0.0058216392109009 0.3181638408477626 0.0 3278 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +72915 C3 LRP1 C3-LRP1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0341500979805349 0.7796725988275006 0.6207977546603366 0.6198216015396206 0.000819605673545 0.0104714078116759 0.0006160270674449 0.0021262886597938 0.209235911083579 0.0025773195876288 388 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +76982 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0307876591086015 0.8718210606749883 0.6593689120110077 0.6198216015396206 1.0 0.2390217618875283 0.0 0.0115497806652229 1.0 0.0 6003 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +79073 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0298476565527434 0.6659645551150886 0.8960994285623033 0.7917001487310438 0.1496557267835524 1.0 0.0 0.0145102781136638 0.1539787521232906 0.0 827 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +82368 VWF LRP1 VWF-LRP1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0287178102472743 0.6332974881236617 0.6207977546603366 0.909150863993142 0.0019871862905238 0.0016667952436519 0.0004737827668352 0.0002457783946333 0.0305474060723854 0.0006361323155216 1572 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +88322 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0272886283271589 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.7029371915698084 0.1973932010691654 0.0 0.0108089260808926 0.1962136838695801 0.0 1673 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +93609 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.026357855390485 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.112230917768503 1.0 0.0 0.0103572183470725 0.1226356917258295 0.0 1577 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +99195 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0255291290978661 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0799339500711946 1.0 0.0 0.0020678246484698 0.0250055184923355 0.0 4836 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +103894 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0248805479600302 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0673400749834054 1.0 0.0 0.0113730355665839 0.1566255196590753 0.0 4836 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +106814 VWF ITGA9 VWF-ITGA9 Mast Cells B Cells Mast Cells -> B Cells 0.0245199089867805 0.8525936146535493 0.6252253442669611 0.6198216015396206 0.0002103933337194 0.0083442542366581 0.0003746411594 0.0048701298701298 0.268090432310002 0.0089285714285714 112 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +107205 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0244749276892436 0.9845127857250529 0.6347970925105053 0.6198216015396206 1.0 0.0554888093272979 0.0 0.0071353212282747 1.0 0.0 6003 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +108201 C1QB LRP1 C1QB-LRP1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0243637383624928 0.9256868304646206 0.6207977546603366 0.6198216015396206 1.0 0.0587195251380622 0.0 0.0054269695227142 0.4625154696884022 0.0 1739 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +109377 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.024231876509138 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0673400749834054 0.8672894033034337 0.0 0.0054084078816581 0.0566309083274734 0.0 5701 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +111851 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0239748135202275 0.6605327397359113 0.7763400818577846 0.7917001487310438 1.0 0.0467761235673353 0.0 0.0038011695906432 0.2137609320916248 0.0 570 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +113412 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0238180164009293 0.8924110508951895 0.6632137581773894 0.6198216015396206 1.0 0.049767778498468 0.0 0.0033557046979865 1.0 0.0 3278 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +113700 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0237892975591202 0.7148920381722296 0.7346293219749174 0.8293805866303694 1.0 0.0416128058995347 0.0 0.0028344270570418 0.2647372895749332 0.0 9905 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +113874 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0237720697579785 0.9356727248601746 0.7746834992804791 0.6198216015396206 0.1750253929104546 0.2295016807597237 0.0 0.0055527722110888 0.3813869406344203 0.0 1996 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +114297 VWF ITGA9 VWF-ITGA9 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0237281296889301 0.9275752708651288 0.7292496872084557 0.7204611100467462 0.1263644540569636 0.2898144908728011 0.0 0.0110356890017906 0.2563021017119551 0.0 2183 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +118520 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0233448458869096 0.8924110508951895 0.8628183098412396 0.6198216015396206 1.0 0.0339152418223636 0.0 0.0150925598396415 1.0 0.0 1542 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +118614 C3 LRP1 C3-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0233367293682136 0.7148920381722296 0.6207977546603366 0.6198216015396206 1.0 0.0587195251380622 0.0 0.0042785234899328 1.0 0.0 3278 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +118791 CD34 SELP CD34-SELP Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0233205273202309 0.9559599666576516 0.6572093097629401 0.6198216015396206 1.0 0.04130664769978 0.0 0.0030817924371147 1.0 0.0 6003 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +118805 VWF SELP VWF-SELP Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0233195234770528 0.955713094717548 0.6572093097629401 0.6198216015396206 1.0 0.04130664769978 0.0 0.003430103130253 1.0 0.0 6003 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +120227 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0231935077815812 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0515877972474039 1.0 0.0 0.0014267596702599 0.0105826022777286 0.0 1577 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +120537 CD34 SELP CD34-SELP Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.0231637995924026 0.9559599666576516 0.7760344326192508 0.6198216015396206 1.0 0.0335947364052305 0.0 0.0112078346028291 0.9427439373371372 0.0 4595 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +120966 VEGFC FLT1 VEGFC-FLT1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0231265196226115 0.8718210606749883 0.6593689120110077 0.6198216015396206 0.1796394187986057 0.2390217618875283 0.0 0.0039164490861618 0.3877884430904479 0.0 6894 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +123346 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0229279849953626 0.7797302331085993 0.657421674383923 0.7917001487310438 0.1132020978253244 0.3162217004298525 0.0 0.0023658639628221 0.2724928592618755 0.0 3945 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +123385 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0229251241634925 0.7941469661104034 0.4614667734221426 0.2461374514707439 1.0 0.1609352200462838 0.0 0.0032349896480331 0.0679605968218023 0.0 184 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +123522 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.02291295090254 0.6605327397359113 0.4642836810638544 0.6198216015396206 1.0 0.0761275033764692 0.0 0.0009511731135066 0.0916071867728942 0.0 1577 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +123663 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.0229014696027216 0.9184503888425788 0.4641352222874551 0.7204611100467462 1.0 0.046975263367762 0.0 0.0071008463635059 1.0 0.0 13942 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +123977 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0228764811911876 0.8924110508951895 0.6631822525600675 0.6198216015396206 1.0 0.0390724515618796 0.0 0.0017749181873648 1.0 0.0 3278 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +124480 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0228322983848256 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.0435116250366991 1.0 0.0 0.0009298998569384 0.0508208254357874 0.0 1165 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +124866 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0228032511354649 0.7797302331085993 0.657421674383923 0.7917001487310438 0.8713412494740926 0.0397596998227057 0.0 0.0137457044673539 1.0 0.0 97 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +126138 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0227051556668824 0.9184503888425788 0.4638256179742202 0.7204611100467462 1.0 0.0446401662952339 0.0 0.0124599062422896 1.0 0.0 2702 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +129986 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0224136731977418 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.7029371915698084 0.0606066271159369 0.0 0.0168097281831187 0.4030349689631853 0.0 233 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +132357 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0222449939841492 0.8924110508951895 0.8622452992050237 0.6198216015396206 1.0 0.0254056950469408 0.0 0.0071335927367055 1.0 0.0 1542 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +132698 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0222204532996341 0.6605327397359113 0.885766439573873 0.6198216015396206 1.0 0.0331922776397286 0.0 0.0012062310449407 0.1339055042855336 0.0 4836 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +133175 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0221892080863561 0.6605327397359113 0.7763400818577846 0.7917001487310438 1.0 0.0293997450046583 0.0 0.0016369047619047 0.1009220363964209 0.0 3360 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +137192 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.021912064032917 0.8640667164982425 0.6331674633943454 0.6198216015396206 1.0 0.0326412663903893 0.0 0.0032483758120939 1.0 0.0 6003 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +137373 CD48 CD2 CD48-CD2 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0218999807191725 0.928447473463448 0.6614977577544194 0.7917001487310438 1.0 0.0226890201466244 0.0 0.007725321888412 1.0 0.0 1165 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +142406 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0215666234609779 0.7797302331085993 0.7763400818577846 0.8693461273411047 0.8713412494740926 0.0219439768073448 0.0 0.0076888285843509 1.0 0.0 737 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +143551 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0214945674507341 0.7800321422220979 0.930308383061206 0.6198216015396206 0.1357656553382984 0.1615013370958009 0.0 0.0030851358846367 0.1164785650851776 0.0 1803 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +143903 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0214726808303816 0.8924110508951895 0.6631822525600675 0.6198216015396206 1.0 0.0267210109213584 0.0 0.0102157256968972 1.0 0.0 1673 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +146576 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0213133619870567 0.8718210606749883 0.6593689120110077 0.6198216015396206 1.0 0.026308073552735 0.0 0.0143325143325143 1.0 0.0 407 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +147559 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0212580000859278 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.0227314494836465 1.0 0.0 0.0110869565217391 0.1760251715473293 0.0 2300 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +148198 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0212212625992041 0.9184503888425788 0.6571792026963191 0.6198216015396206 1.0 0.0244129856070659 0.0 0.0343980343980344 1.0 0.0 407 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +149270 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.021158084681739 0.7797302331085993 0.657421674383923 0.7917001487310438 0.0699064461360958 0.3162217004298525 0.0 0.0013678834210323 0.1575485617057145 0.0 30217 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +149630 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0211388626037785 0.4625081978296446 0.657421674383923 0.6198216015396206 0.149715856631667 0.3162217004298525 0.0 0.0011185682326621 0.1288332130618527 0.0 3278 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +151861 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0210188018062866 0.2534163760166434 0.6580560501976399 0.2461374514707439 0.2100740470724093 1.0 0.0 0.003584229390681 0.1958850674365339 0.0 186 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +153295 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0209358173320561 0.4625081978296446 0.657421674383923 0.2461374514707439 0.3558005706994493 0.3162217004298525 0.0 0.0 0.0 0.0 186 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +154641 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Pericytes Pericytes -> Pericytes 0.0208592107561958 0.9184503888425788 0.896164124004365 1.0 0.1169448695751571 0.0855781119790033 0.0 0.0059152677857713 0.2980700093795599 0.0 12510 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +156303 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0207687526511349 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.1740454925211078 0.1281708518900828 0.0 0.0040870022803017 0.1156149841975887 0.0 5701 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +156368 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0207648031569894 0.662063103571249 0.6331674633943454 1.0 0.585843718590581 0.0326412663903893 0.0 0.0003796764814167 0.1293320693845585 0.0 423716 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +156551 CD34 SELP CD34-SELP Pericytes Pericytes Pericytes -> Pericytes 0.0207547891283466 0.9303167350027568 0.8819126042133903 1.0 0.1314667522621683 0.0741032966028748 0.0 0.0042765787370103 0.2150136889238992 0.0 12510 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +157240 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0207176608190253 0.6249837837987587 0.4638256179742202 0.2461374514707439 0.2159908053119969 0.5131068416842878 0.0 0.0036231884057971 0.0875116251061578 0.0 184 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +159199 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0206102432614238 0.6605327397359113 0.4642836810638544 0.6198216015396206 1.0 0.040323117011325 0.0 0.0015494867325198 0.107774900356444 0.0 5163 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +159295 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.020605382805311 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0265972645862203 1.0 0.0 0.0092812499999999 0.1644192840994506 0.0 800 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +159950 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0205736126441568 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.7029371915698084 0.0362497659817488 0.0 0.0049382716049382 0.1684222968049634 0.0 135 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +160148 A2M LRP1 A2M-LRP1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0205632515861593 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.3743986430148447 0.0587195251380622 0.0 0.003771395416304 0.4849282608591048 0.0 6894 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +161846 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0204758620766031 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0186793449598515 0.8672894033034337 0.0 0.0040889970747122 0.042815487211061 0.0 15611 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +162699 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0204324111686429 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.0179229861158654 1.0 0.0 0.0072463768115942 0.1150491317302806 0.0 69 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +163007 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0204168754211095 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0244483651952677 0.8672894033034337 0.0 0.0180299032541776 0.2467721698325534 0.0 379 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +163082 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.020412962839729 0.6593525851613742 0.878254460598671 0.6198216015396206 0.0201572483258557 1.0 0.0 0.0265765765765765 0.3147589507494404 0.0 370 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +164169 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0203595535011388 0.7797302331085993 0.4642836810638544 0.2461374514707439 0.8713412494740926 0.0917308979735958 0.0 0.0117493472584856 0.6465157334732929 0.0 383 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +164569 CD34 SELP CD34-SELP Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.0203380816010989 0.9559599666576516 0.4623922682986163 0.7204611100467462 1.0 0.0222228052993653 0.0 0.0042676803901879 1.0 0.0 13942 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +164584 VWF SELP VWF-SELP Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.0203372061387138 0.955713094717548 0.4623922682986163 0.7204611100467462 1.0 0.0222228052993653 0.0 0.0070226001225857 1.0 0.0 13942 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +165004 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0203155193027326 0.8498991475190484 0.7346293219749174 0.6198216015396206 0.018166235813628 1.0 0.0 0.007578125 0.0562086836049259 0.0 800 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +166082 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0202641565956774 0.6605327397359113 0.4642836810638544 0.2461374514707439 1.0 0.0917308979735958 0.0 0.0018115942028985 0.0996841891788531 0.0 184 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +167889 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0201794785921013 0.8718210606749883 0.4630488285702799 0.7204611100467462 1.0 0.0232163927704059 0.0 0.0057364914877868 1.0 0.0 2702 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +168621 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0201425929116493 0.4636527906642655 0.878254460598671 0.2461374514707439 0.0666348171285698 1.0 0.0 0.0165190107050572 0.1956424470985176 0.0 1806 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +170623 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0200467669081878 0.6659645551150886 0.8960994285623033 0.7917001487310438 0.0137371823984124 1.0 0.0 0.0060240963855421 0.0639259176736753 0.0 83 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +175228 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0198306726654048 0.6249837837987587 0.4638256179742202 0.2461374514707439 0.1661175896787547 0.5131068416842878 0.0 0.0056062333713416 0.1354085236819341 0.0 877 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +175897 CCN1 CAV1 CCN1-CAV1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0198006475706376 0.9219165193585238 0.62431395375366 0.6198216015396206 0.2646489893253856 0.0638329144736252 0.0 0.0007204332269606 0.1880751121872973 0.0 6894 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +176081 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0197922901954521 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.0673400749834054 0.2295016807597237 0.0 0.0015350877192982 0.0763101841740455 0.0 30400 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +178233 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.019698892868547 0.6593525851613742 0.777821334064334 0.7917001487310438 0.4518617096918393 0.0318483483218543 0.0 0.002216848045143 0.2805453778847739 0.0 827 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +178901 COL4A2 CD93 COL4A2-CD93 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0196703749196414 0.8840293712888387 0.6587114738285964 0.6198216015396206 0.5544396796022323 0.0289462771086338 0.0 0.0024804177545691 0.5280771539027573 0.0 6894 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +180440 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0196024642798774 0.7296454584598743 0.4638256179742202 0.8293805866303694 0.293296467876477 0.0689186266365139 0.0 0.0014473623268954 0.1763579002551854 0.0 7197 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +180712 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0195900898387638 0.2542249848376565 0.9694036398779844 0.2461374514707439 0.1711385759005754 0.5444650460041837 0.0 0.0124039938556067 0.2469630547169386 0.0 1736 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +181020 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0195765581106757 0.662063103571249 0.7167436199046466 0.6198216015396206 0.585843718590581 0.0326667674102811 0.0 0.0024271844660194 0.051380740883184 0.0 103 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +181313 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.019564563038953 0.7148920381722296 0.6207977546603366 0.6198216015396206 1.0 0.0203874717835032 0.0 0.0072470817120622 0.9269846143190824 0.0 1542 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +181384 MMRN2 CD93 MMRN2-CD93 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.0195619611456417 0.9845127857250529 0.7779918296243433 0.6198216015396206 1.0 0.0118035014556376 0.0 0.0151251360174102 1.0 0.0 4595 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +182461 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0195187584027787 0.8978557803479422 0.657421674383923 0.6198216015396206 0.0477973731763516 0.3162217004298525 0.0 0.0012459267778416 0.1435019745260544 0.0 1739 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +183456 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0194746804080715 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0186793449598515 1.0 0.0 0.0009660362009355 0.0525189277009667 0.0 3278 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +183560 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.019470075823629 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.1339639999453202 0.1449812920932466 0.0 0.0016487000634115 0.1351401482940367 0.0 1577 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +184973 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0194133948941587 0.662063103571249 0.9015117569158254 0.6198216015396206 0.585843718590581 0.0246995741084876 0.0 0.0012028127313101 0.115894884492172 0.0 1351 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +185574 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.019389113493642 0.2451358214448441 0.663300745568453 0.2461374514707439 0.1327555461750915 1.0 0.0 0.0039682539682539 0.068025052745317 0.0 186 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +186250 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0193609251144508 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.0161757332769496 1.0 0.0 0.0018588931136459 0.1015921034157536 0.0 3945 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +190985 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.019166797991409 0.6605327397359113 0.9130058539314824 0.6198216015396206 1.0 0.0132636308162813 0.0 0.0 0.0 0.0 1351 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +192050 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0191263337925238 0.6342079770588467 0.6580560501976399 0.8824495942126559 0.0673400749834054 0.1973932010691654 0.0 0.003889245700421 0.0696086535370421 0.0 4671 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +192133 CD48 CD2 CD48-CD2 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0191229533201498 0.9011089648206808 0.6614977577544194 0.7917001487310438 0.4567172527116189 0.0226890201466244 0.0 0.0025348542458808 0.3674019889750533 0.0 3945 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +192849 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0190945952170296 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0131302879503246 1.0 0.0 0.0032333258139709 0.0361032908197113 0.0 4836 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +193263 CD48 CD2 CD48-CD2 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0190783867882019 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0112468593062777 1.0 0.0 0.0379008746355685 0.402192799824465 0.0 343 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +193448 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0190716979445798 0.6582846571368821 0.6587114738285964 0.8824495942126559 0.4344545964241579 0.0289462771086338 0.0 0.0024432209222298 0.520158005073991 0.0 5812 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +193643 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0190637539492197 0.6160088550075702 0.9255624071030766 0.7917001487310438 0.0106340017102282 1.0 0.0 0.0023634165109376 0.0190194977037811 0.0 827 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +193756 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0190586288574243 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0161757332769496 0.8672894033034337 0.0 0.0116890707188778 0.159986290772541 0.0 1711 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +193970 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.01904950850338 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0425206505665654 0.3162217004298525 0.0 0.0011383197290243 0.1311081290346257 0.0 6003 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +194027 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0190473381276971 0.9184503888425788 0.4641352222874551 0.2461374514707439 1.0 0.0455121851821151 0.0 0.0149397590361445 1.0 0.0 2075 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +194464 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0190310538763681 0.6249837837987587 0.6580560501976399 0.8824495942126559 0.2159908053119969 0.0606066271159369 0.0 0.0025459669094054 0.061042848708523 0.0 11947 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +195605 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0189896129767226 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.1153131738111426 0.1449812920932466 0.0 0.0041666666666666 0.3415320734931025 0.0 800 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +195892 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0189778504143148 0.6160088550075702 0.9008184599638702 0.7917001487310438 0.0106340017102282 1.0 0.0 0.0024733428602836 0.0199566642475421 0.0 827 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +196192 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0189657726083413 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0673400749834054 0.1993723722552783 0.0 0.0041356492969396 0.1532226029064204 0.0 4836 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +196338 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.01896077174464 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0110717612136884 1.0 0.0 0.0051189400782896 0.0812722863713455 0.0 3321 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +196912 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0189375449616175 0.6605327397359113 0.885766439573873 0.6198216015396206 1.0 0.0127192475389894 0.0 0.0004677541951704 0.070548809741936 0.0 5701 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +197487 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0189137547811553 0.6630837220165452 0.6587114738285964 0.8824495942126559 0.4103175828613323 0.0289462771086338 0.0 0.0029741421689116 0.4395600306448505 0.0 5812 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +197508 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0189130825158481 0.8718210606749883 0.777821334064334 0.6198216015396206 1.0 0.0108892901157311 0.0 0.0086396481306943 1.0 0.0 2122 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +197802 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0189018862341944 0.6593525851613742 0.6593689120110077 0.8824495942126559 0.4518617096918393 0.026308073552735 0.0 0.0033062693563237 0.2409738678859874 0.0 11947 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +198068 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0188913257966405 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0131302879503246 1.0 0.0 0.0005169561621174 0.0029068309711092 0.0 4836 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +199256 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0188465712074476 0.8718210606749883 0.8998347793593909 0.8875000050982297 1.0 0.0064362797035136 0.0 0.0029658284977433 1.0 0.0 2585 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +199689 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0188304655306572 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.4518617096918393 0.0521374123931907 0.0 0.0012682308180088 0.2256287095667677 0.0 1577 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +199754 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0188281696436179 0.4630253981438691 0.8817184225858201 0.2461374514707439 0.0443339118517084 1.0 0.0 0.0100221483942414 0.0857561471087968 0.0 1806 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +200234 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0188106826977736 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.1740454925211078 0.0627790816848129 0.0 0.0032142857142857 0.0704938813284122 0.0 3360 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +200440 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0188033584741961 0.7941469661104034 0.8445107771175474 0.7917001487310438 1.0 0.0083242517891534 0.0 0.0042609546841711 0.4984730323378384 0.0 827 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +200840 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0187904200519728 0.9184503888425788 0.7754072541855492 0.6198216015396206 1.0 0.009971631136135 0.0 0.0094250706880301 1.0 0.0 2122 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +202232 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0187393064483435 0.6593525851613742 0.878254460598671 0.6198216015396206 0.0120646829101097 1.0 0.0 0.0286259541984732 0.3390306980190311 0.0 262 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +202702 MMRN2 CD93 MMRN2-CD93 Pericytes Macrophages Pericytes -> Macrophages 0.0187192661878118 0.9468422434493456 0.944024288971064 0.8875000050982297 0.1120119983652299 0.0484215930647349 0.0 0.0125882352941176 0.2816569241581239 0.0 2125 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +202742 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0187174083687607 0.7324582304061453 0.62431395375366 0.6198216015396206 0.2376713873232418 0.0638329144736252 0.0 0.0026169447170428 0.6831752795775448 0.0 5095 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +203476 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0186919455902834 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.0142750905665976 1.0 0.0 0.0108811040339702 0.128838813205462 0.0 157 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +204574 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.018652883327139 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.7696906278989153 0.0289462771086338 0.0 0.0010982306284319 0.2338116244825542 0.0 3278 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +204745 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0186464508779992 0.6249837837987587 0.7746834992804791 0.8693461273411047 0.0435116250366991 0.2295016807597237 0.0 0.0016960651289009 0.1164926393588572 0.0 737 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +204879 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.018641311860227 0.4625081978296446 0.657421674383923 0.6198216015396206 0.0704104148800194 0.3162217004298525 0.0 0.0015374550212626 0.1770792916726506 0.0 5095 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +207984 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0185301588600459 0.9356727248601746 0.6580560501976399 0.6198216015396206 0.1750253929104546 0.0606066271159369 0.0 0.0077470686767169 0.1857459888501882 0.0 398 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +208223 COL4A1 CD93 COL4A1-CD93 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.0185216673957839 0.7766289238087107 0.4630027772793905 0.7204611100467462 1.0 0.0155837683010033 0.0 0.0030022337438777 0.7074243338794526 0.0 13942 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +210064 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0184560977993734 0.9219165193585238 0.9694036398779844 0.9429656149619918 0.0086134406931133 0.5444650460041837 0.0 0.0037186658379946 0.0740384980445275 0.0 3218 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +210573 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0184384766523751 0.8023917560710954 0.9255624071030766 0.6198216015396206 0.0085367158000785 1.0 0.0 0.0073608916243865 0.0592364742735329 0.0 1093 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +213863 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0183246725529629 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0131302879503246 1.0 0.0 0.0026085202052228 0.0200269415857373 0.0 1577 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +214008 CD34 SELP CD34-SELP Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0183195805865101 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.0082993421103349 1.0 0.0 0.0002225189141076 0.0026908475173327 0.0 2247 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +215059 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.018282214464272 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.1671376945154473 0.0587195251380622 0.0 0.002553750096524 0.3283627029991431 0.0 30217 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +217133 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0182138483968672 0.6303642896310324 0.956444566971872 0.6198216015396206 0.0097699360831605 1.0 0.0 0.0043062448304383 0.0390877693319288 0.0 4836 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +217943 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0181858994116771 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0411214967239829 0.2295016807597237 0.0 0.0036787484510532 0.2526713799476577 0.0 2152 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +219239 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0181459400685778 0.8718210606749883 0.4630488285702799 0.2461374514707439 1.0 0.0359289752254096 0.0 0.0043373493975903 1.0 0.0 2075 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +220709 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0180992156857437 0.8718210606749883 0.7472387841445823 0.7827641335561659 1.0 0.0068935067166085 0.0 0.010575296108291 0.6430418090829805 0.0 394 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +221198 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0180828824789865 0.4648000335061383 0.7346293219749174 0.8293805866303694 0.2966815529783992 0.0416128058995347 0.0 0.0034115766447921 0.2023743065063021 0.0 9905 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +222084 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0180533989489422 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.3309594876493178 0.0587195251380622 0.0 0.0032455426750728 0.228829949272533 0.0 3278 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +222627 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0180346323861358 0.662063103571249 0.6331674633943454 0.7917001487310438 0.585843718590581 0.0176963220730796 0.0 0.0008313180169286 0.1519686731774418 0.0 827 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +223122 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0180183630714039 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.011891719340537 1.0 0.0 0.0011572606214331 0.020501113847005 0.0 1577 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +223644 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0180029112963395 0.6213271600240247 0.942159351720962 0.6198216015396206 0.0093830613230477 1.0 0.0 0.0082882882882882 0.1221391135878295 0.0 370 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +224719 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0179698390905746 0.9184503888425788 0.7480927101953669 0.7827641335561659 1.0 0.006260692484444 0.0 0.0101522842639593 1.0 0.0 394 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +225491 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0179448539589452 0.6593525851613742 0.777821334064334 0.7917001487310438 0.4518617096918393 0.0182001711419816 0.0 0.0011019736842105 0.1319861094406658 0.0 30400 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +227213 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0178883825823202 0.7797302331085993 0.7467524951532132 0.6198216015396206 0.8713412494740926 0.0104195741475089 0.0 0.0133887349953831 0.9238227146814404 0.0 361 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +228123 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0178605268680243 0.6582846571368821 0.944024288971064 0.6198216015396206 0.1740454925211078 0.0484215930647349 0.0 0.0035529237601776 0.1316552661462411 0.0 1351 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +229022 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Macrophages Pericytes -> Macrophages 0.017831837997302 0.8640667164982425 0.9015117569158254 0.8875000050982297 0.1882781599600688 0.0246995741084876 0.0 0.0045294117647058 0.4364234262105768 0.0 2125 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +229154 MMRN2 CD93 MMRN2-CD93 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0178278853767585 0.9468422434493456 0.7779918296243433 0.6198216015396206 0.1120119983652299 0.0627790816848129 0.0 0.0128245725142495 0.2808345630322724 0.0 1579 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +229736 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0178106381638467 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0069047442087267 1.0 0.0 0.0080106809078771 0.1103203320409693 0.0 2247 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +229952 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0178045646173551 0.6605327397359113 0.7467524951532132 0.6198216015396206 1.0 0.0104195741475089 0.0 0.0015432098765432 0.1064814814814814 0.0 756 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +231007 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0177726336830576 0.6342079770588467 0.6580560501976399 0.8824495942126559 0.0085570823799139 1.0 0.0 0.0034707875382199 0.188690692552376 0.0 12101 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +231067 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0177704406084475 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.0141498126994191 1.0 0.0 0.0104028331119964 0.1651634945556884 0.0 753 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +231111 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0177690544212952 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.0839650520556947 0.1281708518900828 0.0 0.0059554634904194 0.1403280769384169 0.0 1931 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +231330 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0177623520335925 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.0693389464442948 0.2390217618875283 0.0 0.0012202562538133 0.1208240583312112 0.0 3278 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +232084 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0177388732710831 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2966815529783992 0.0587195251380622 0.0 0.0018049623754321 0.2320831334339944 0.0 3278 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +232895 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.0177135399401956 0.9845127857250529 0.6347970925105053 0.6198216015396206 1.0 0.0079745943515326 0.0 0.0099383387740297 1.0 0.0 4595 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +233213 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0177045692925193 0.7766289238087107 0.8817184225858201 0.9429656149619918 0.0047694898966413 1.0 0.0 0.0041644702161307 0.0317841072883222 0.0 2710 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +233260 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0177029923039425 0.6249837837987587 0.6580560501976399 0.8824495942126559 0.0084812136822336 1.0 0.0 0.0017094017094017 0.0934221090851161 0.0 12090 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +234351 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0176689308268929 0.7835752212271604 0.8818326005152037 0.7827641335561659 0.0064863313435223 0.8672894033034337 0.0 0.005784061696658 0.0791654528151143 0.0 389 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +234988 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0176515029919996 0.7800321422220979 0.6331674633943454 0.8693461273411047 0.1357656553382984 0.0518891167572028 0.0 0.0052681992337164 0.2696335408710801 0.0 1044 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +235329 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0176414942549889 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0085570823799139 1.0 0.0 0.0189189189189189 0.260544820221082 0.0 370 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +235519 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0176356001899391 0.7741139100414175 0.8604147465201248 0.6198216015396206 0.1671376945154473 0.0436001007095475 0.0 0.0063157894736842 0.1809319071936133 0.0 475 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +236835 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0175949634551486 0.9845127857250529 0.7154802332407408 0.7204611100467462 1.0 0.0058465532256424 0.0 0.0054897606711078 1.0 0.0 2702 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +237046 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0175891598971926 0.7482742921073442 0.8817184225858201 0.7827641335561659 0.005733874009046 1.0 0.0 0.0106521739130434 0.0911470632025688 0.0 460 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +239284 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0175220667671871 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0083565457974945 1.0 0.0 0.0013513513513513 0.0163414442471533 0.0 370 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +240110 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0174980128392482 0.8771078809726828 0.6580560501976399 0.6198216015396206 0.0080232294691882 1.0 0.0 0.0009584052137243 0.0523786983082163 0.0 1739 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +241068 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0174686909730585 0.6249837837987587 0.6580560501976399 0.8824495942126559 0.2159908053119969 0.0362497659817488 0.0 0.0017956184137548 0.0612404909295501 0.0 12020 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +242366 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0174295509067538 0.7941469661104034 0.773263018678637 0.6198216015396206 1.0 0.0073658308476012 0.0 0.0036304677311339 0.661015611748457 0.0 1351 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +242602 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0174222804077887 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.0435116250366991 0.1973932010691654 0.0 0.0042013888888888 0.0762675204815105 0.0 2400 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +242850 COL4A2 CD93 COL4A2-CD93 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0174152213552807 0.8840293712888387 0.7779918296243433 0.6198216015396206 0.5544396796022323 0.0118035014556376 0.0 0.0071966275218307 0.7282846332947056 0.0 3321 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +242867 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0174147653353124 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.1468839381042521 0.0467761235673353 0.0 0.0158730158730158 0.8926280680749168 0.0 42 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +244073 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0173783237145072 0.6605327397359113 0.657421674383923 0.8824495942126559 0.0227314494836465 0.3162217004298525 0.0 0.0007742601514108 0.0891768782085054 0.0 5812 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +244293 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.017372359757851 0.6605327397359113 0.4642836810638544 0.6198216015396206 1.0 0.0144613249009303 0.0 0.017799352750809 0.1031514325545922 0.0 103 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +244431 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.017368402751491 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0065101973396288 1.0 0.0 0.008471965495995 0.1003374893911324 0.0 2164 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +244457 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.017367527251582 0.8640667164982425 0.7167436199046466 0.7204611100467462 0.1882781599600688 0.0326667674102811 0.0 0.0115799492385786 0.245134384962348 0.0 394 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +244781 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0173584989699499 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0078992851324392 1.0 0.0 0.0005910165484633 0.0071469673421356 0.0 1692 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +245210 VEGFC FLT1 VEGFC-FLT1 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0173461323290394 0.8718210606749883 0.4630488285702799 0.7204611100467462 0.1796394187986057 0.0521374123931907 0.0 0.0019136420847139 0.3404526904846531 0.0 12977 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +245260 CD48 CD2 CD48-CD2 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0173447464130362 0.928447473463448 0.8581827408615759 0.8693461273411047 1.0 0.003930762149527 0.0 0.0027137042062415 0.7275561907236588 0.0 737 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +245741 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.017331167140124 0.4636527906642655 0.878254460598671 0.7204611100467462 0.0693389464442948 0.1332188634280341 0.0 0.0022526850724916 0.084904054080442 0.0 15611 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +246093 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0173213274584466 0.7941469661104034 0.773263018678637 0.6198216015396206 1.0 0.0070956399217802 0.0 0.0037712681985616 0.4733075215997257 0.0 5701 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +246205 VWF ITGA9 VWF-ITGA9 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0173180161429995 0.955713094717548 0.7292496872084557 0.7204611100467462 1.0 0.0053724660607752 0.0 0.011699271192942 1.0 0.0 474 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +247079 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0172932662862649 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.2159908053119969 0.0689186266365139 0.0 0.0013739167195096 0.1674087153407777 0.0 1577 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +247553 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0172806929048457 0.6605327397359113 0.657421674383923 0.8824495942126559 1.0 0.0069492509109592 0.0 0.0006065796046528 0.103801859286843 0.0 4671 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +247862 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0172722050629592 0.9184503888425788 0.6580560501976399 0.6198216015396206 0.1169448695751571 0.0606066271159369 0.0 0.0113065326633165 0.3201371791745656 0.0 398 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +248448 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0172559347291185 0.6213271600240247 0.62431395375366 0.7917001487310438 0.1339639999453202 0.0641739251983978 0.0 0.0011173245614035 0.1061404413457031 0.0 30400 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +248695 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0172485194212351 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0101610580570933 1.0 0.0 0.0040747842761265 0.0698512286579429 0.0 3278 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +249250 CD48 CD2 CD48-CD2 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0172332728178244 0.7453966474499909 0.8960994285623033 0.6198216015396206 0.006326966401379 1.0 0.0 0.0141752577319587 0.1504236155568701 0.0 388 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +249825 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0172167393841673 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0073929685753755 1.0 0.0 0.005243288590604 0.0722087603980407 0.0 4768 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +251061 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0171820738855086 0.7797302331085993 0.657421674383923 0.7917001487310438 0.0200499113739789 0.3162217004298525 0.0 0.0018820577164366 0.2167695592420884 0.0 797 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +251080 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0171815552820742 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0085570823799139 0.8672894033034337 0.0 0.011433597185576 0.1197200744170018 0.0 379 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +251665 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0171656030336453 0.8533682807143209 0.7779918296243433 0.8693461273411047 0.0706049302656684 0.0627790816848129 0.0 0.0058839627805145 0.1181476184438864 0.0 1044 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +251846 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0171606683183659 0.9845127857250529 0.7779918296243433 0.6198216015396206 1.0 0.0053794918117879 0.0 0.0096397767630644 1.0 0.0 1971 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +253471 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0171142300208594 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0084812136822336 0.8672894033034337 0.0 0.009903381642512 0.1355458729949822 0.0 345 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +253935 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0171017652191346 0.6342079770588467 0.4638256179742202 0.2461374514707439 0.0673400749834054 0.5131068416842878 0.0 0.0 0.0 0.0 184 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +255098 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0170711547781285 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.454846709299195 0.0289462771086338 0.0 0.0008062407391266 0.1191574524251222 0.0 3278 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +255160 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0170695922738685 0.9184503888425788 0.4638256179742202 0.7204611100467462 0.1169448695751571 0.0689186266365139 0.0 0.0035447329891346 0.3333594121977672 0.0 12977 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +256509 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0170338360953294 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0073929685753755 1.0 0.0 0.0011444921316165 0.0622207526555297 0.0 1165 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +257374 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0170089171577501 0.9356727248601746 0.6580560501976399 0.6198216015396206 0.1750253929104546 0.0362497659817488 0.0 0.004420866489832 0.1507759288373346 0.0 377 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +258133 VEGFC FLT1 VEGFC-FLT1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0169893634843897 0.8718210606749883 0.777821334064334 0.6198216015396206 0.1796394187986057 0.0318483483218543 0.0 0.0038141122151962 0.4826815058666288 0.0 3321 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +259532 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0169528187193074 0.9470274865242416 0.6580560501976399 0.6198216015396206 0.0061455194924501 1.0 0.0 0.0002932723326881 0.0160279001157818 0.0 5683 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +260326 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0169318674092121 0.8924110508951895 0.6632137581773894 0.6198216015396206 1.0 0.0064230792457803 0.0 0.0087787748731954 1.0 0.0 233 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +261681 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0168935623855169 0.7324582304061453 0.62431395375366 0.6198216015396206 1.0 0.0082011408892332 0.0 0.0060085836909871 1.0 0.0 233 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +261912 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0168876892990187 0.6561647292424944 0.6207977546603366 0.8824495942126559 0.1098969873322313 0.0587195251380622 0.0 0.0028031085111264 0.3604253559368226 0.0 5812 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +262108 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0168826865865528 0.9468422434493456 0.6347970925105053 0.6198216015396206 0.1120119983652299 0.0554888093272979 0.0 0.0017406440382941 0.2848689528076354 0.0 6894 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +262626 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0168683523634299 0.2534163760166434 0.8818326005152037 0.2461374514707439 0.2100740470724093 0.1993723722552783 0.0 0.0015688445921004 0.0685628943562124 0.0 1806 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +264051 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.016831148151578 0.6605327397359113 0.657421674383923 0.8824495942126559 1.0 0.0059327142047454 0.0 0.00181641708264 0.4867032105286795 0.0 12020 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +264128 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0168293125221027 0.7451589345683471 0.956444566971872 0.7827641335561659 0.0040724665904272 1.0 0.0 0.011141304347826 0.1287370103104676 0.0 460 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +264366 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0168225568940223 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.1928969878996252 0.0289462771086338 0.0 0.0009696528444253 0.206437610525318 0.0 30217 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +265660 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0167884834050774 0.9845127857250529 0.6347970925105053 0.6198216015396206 1.0 0.0057802287131517 0.0 0.0067647556232031 1.0 0.0 1971 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +266266 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0167738903656224 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.7029371915698084 0.0090444648829713 0.0 0.0006399707441945 0.0900439341691099 0.0 3646 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +266513 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0167678743779021 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0073929685753755 0.8672894033034337 0.0 0.0085794655414908 0.0898347419813912 0.0 3555 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +267324 A2M LRP1 A2M-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0167465401334889 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2100317344087863 0.0587195251380622 0.0 0.0043833824010467 0.5636179105566016 0.0 5095 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +268331 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0167205471725743 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0072827533047186 1.0 0.0 0.0067232837933474 0.0657416512612752 0.0 157 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +268374 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0167196599965391 0.6582846571368821 0.6587114738285964 1.0 0.1740454925211078 0.0289462771086338 0.0 0.0001729932313153 0.0368299948946704 0.0 423716 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +269011 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.016703408322575 0.6605327397359113 0.657421674383923 0.8824495942126559 0.0179229861158654 0.3162217004298525 0.0 0.0016404742211193 0.1889447229776436 0.0 12090 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +269215 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0166986755151074 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.0673400749834054 0.0826982152707935 0.0 0.0010197368421052 0.0378491919334927 0.0 30400 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +269378 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0166941400422893 0.662063103571249 0.7167436199046466 0.6198216015396206 0.585843718590581 0.0125623889131764 0.0 0.0003170577045022 0.1472047802696163 0.0 1577 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +270109 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0166762455671399 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0244483651952677 0.2295016807597237 0.0 0.0016602809706257 0.1140348380788977 0.0 1305 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +270309 COL4A1 CD93 COL4A1-CD93 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0166715244504037 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.4857192596400828 0.0118035014556376 0.0 0.0064954617800146 0.616318732019864 0.0 3321 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +271491 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0166434522116559 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.1468839381042521 0.0761275033764692 0.0 0.0042462845010615 0.4089583398184125 0.0 157 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +272556 THBS2 CD36 THBS2-CD36 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0166181999486842 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0063387366560491 1.0 0.0 0.004465534116331 0.0641179754113725 0.0 4768 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +272571 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0166179846230728 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.0070489045197697 1.0 0.0 0.0064935064935064 0.0768870206142193 0.0 77 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +273041 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0166072833595881 0.7797302331085993 0.657421674383923 0.7917001487310438 0.8713412494740926 0.0059327142047454 0.0 0.0020576131687242 0.5513309387008506 0.0 81 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +273687 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0165912994134594 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0215813276111062 0.2390217618875283 0.0 0.0009376620224818 0.092842901271981 0.0 30217 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +273778 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0165888628163402 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.1882781599600688 0.0326412663903893 0.0 0.001106034232666 0.3767567998604467 0.0 6894 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +274014 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0165825325164011 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.4344545964241579 0.0118035014556376 0.0 0.0067391304347826 0.6819868226516577 0.0 2300 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +274378 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.016574293249672 0.7835752212271604 0.6580560501976399 0.6198216015396206 0.0064863313435223 1.0 0.0 0.0031773541305603 0.1736485476495443 0.0 1154 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +275228 CD34 SELP CD34-SELP Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0165541244159037 0.9303167350027568 0.6572093097629401 0.6198216015396206 0.1314667522621683 0.04130664769978 0.0 0.0006527415143603 0.2491120481342743 0.0 6894 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +275284 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0165528872218853 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.1661175896787547 0.0689186266365139 0.0 0.0029166666666666 0.3553893862782393 0.0 800 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +275592 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0165453362096191 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0799339500711946 0.0741032966028748 0.0 0.0005262234695667 0.0264569545769603 0.0 5701 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +276192 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.0165303136837878 0.9184503888425788 0.7746834992804791 0.6198216015396206 1.0 0.0046263543438723 0.0 0.0019586507072905 1.0 0.0 4595 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +276205 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.016529859868616 0.6659645551150886 0.937587088419394 0.7917001487310438 0.1496557267835524 0.0275738893167071 0.0 0.0026315789473684 0.1097587844551184 0.0 570 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +276721 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.016516590401041 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0673400749834054 0.0855781119790033 0.0 0.0021048938782669 0.1060654835521021 0.0 5701 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +278511 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0164725425388393 0.6593525851613742 0.777821334064334 0.7917001487310438 0.4518617096918393 0.0108892901157311 0.0 0.000595238095238 0.0738626007533719 0.0 3360 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +279225 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0164551540483608 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.4518617096918393 0.0232163927704059 0.0 0.0007101814190715 0.1389583259982097 0.0 5163 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +279602 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0164452034935296 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.4103175828613323 0.0118035014556376 0.0 0.0064285714285714 0.6099718735543618 0.0 2300 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +279933 VWF SELP VWF-SELP Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0164371846936709 0.9275752708651288 0.6572093097629401 0.6198216015396206 0.1263644540569636 0.04130664769978 0.0 0.0008835087164068 0.2998756585300063 0.0 6894 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +279976 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0164362051065432 0.6160088550075702 0.8950084308969304 0.7917001487310438 0.0106340017102282 0.4247538686915498 0.0 0.0021103896103896 0.0217549156358684 0.0 3360 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +280703 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0164188663850633 0.831981591331937 0.7763400818577846 0.6198216015396206 0.0048935684578858 1.0 0.0 0.0160349854227405 0.2545839387267726 0.0 343 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +282266 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0163802051758844 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0415873844357376 0.1281708518900828 0.0 0.0028816999523893 0.067901249547218 0.0 5701 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +282970 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0163625497386105 0.9845127857250529 0.4630027772793905 0.7204611100467462 1.0 0.0058437228618857 0.0 0.0056439674315321 1.0 0.0 2702 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +283657 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0163456096510433 0.6213271600240247 0.9694036398779844 0.6198216015396206 0.0093830613230477 0.5444650460041837 0.0 0.0041336851363236 0.0823015167846967 0.0 379 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +283663 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0163454082907885 0.6213271600240247 0.942159351720962 0.6198216015396206 0.0052560850129547 1.0 0.0 0.0030534351145038 0.0449964872494161 0.0 262 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +283775 CD48 CD2 CD48-CD2 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0163428362920357 0.928447473463448 0.4603649459881741 0.6198216015396206 1.0 0.0071918009517169 0.0 0.0043035993740219 1.0 0.0 1278 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +284776 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0163178103101345 0.6242573126045354 0.6176321640000088 0.8824495942126559 0.1932385901170197 0.02871400543887 0.0 0.0015556893782977 0.7528216975920475 0.0 5812 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +286331 CD48 CD2 CD48-CD2 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0162799118977409 0.928447473463448 0.6614977577544194 0.7917001487310438 1.0 0.0038288178384739 0.0 0.0 0.0 0.0 97 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +287145 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0162605103268729 0.6593525851613742 0.6593689120110077 0.8824495942126559 0.0201572483258557 0.2390217618875283 0.0 0.0020659449632261 0.2045601929642752 0.0 12101 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +287889 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0162422079791107 0.4593282471594782 0.8960994285623033 0.2461374514707439 0.0181222899145132 1.0 0.0 0.0079113924050632 0.0839533412486559 0.0 316 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +288021 A2M LRP1 A2M-LRP1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0162394273381449 0.8937519114898692 0.9078204025796472 0.9429656149619918 0.3743986430148447 0.0064028969591119 0.0 0.0031186783546864 0.4390545348906201 0.0 2966 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +288469 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0162283541220544 0.7797302331085993 0.657421674383923 0.7917001487310438 0.1132020978253244 0.0397596998227057 0.0 0.0074525745257452 0.5718860649669539 0.0 246 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +289025 VEGFC FLT1 VEGFC-FLT1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0162141085587537 0.8963332422588541 0.878254460598671 0.8875000050982297 0.0026007495851186 1.0 0.0 0.0043608124253285 0.0516471615317561 0.0 2790 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +289038 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0162139223023485 0.9184503888425788 0.836885603004631 0.8567148457705164 1.0 0.0027591088867233 0.0 0.0133333333333333 0.1964912280701755 0.0 225 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +291236 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0161631547688041 0.7840818683779507 0.896164124004365 0.7827641335561659 0.0032417203409647 1.0 0.0 0.0065217391304347 0.089815139889876 0.0 460 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +291567 CD34 SELP CD34-SELP Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0161564941912358 0.9559599666576516 0.6572093097629401 0.6198216015396206 1.0 0.0045674276780054 0.0 0.0036855036855036 1.0 0.0 407 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +291594 VWF SELP VWF-SELP Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0161557987272674 0.955713094717548 0.6572093097629401 0.6198216015396206 1.0 0.0045674276780054 0.0 0.0071476435112798 1.0 0.0 407 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +292328 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0161404375275293 0.6605327397359113 0.885766439573873 0.6198216015396206 0.1468839381042521 0.0331922776397286 0.0 0.0013513513513513 0.1500155255733222 0.0 370 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +292902 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0161276207468458 0.6659645551150886 0.8960994285623033 0.7917001487310438 0.0037243679732516 1.0 0.0 0.0 0.0 0.0 69 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +293347 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.016117741707325 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.1468839381042521 0.0293997450046583 0.0 0.0 0.0 0.0 209 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +293402 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0161163591051998 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0053032910137447 1.0 0.0 0.0007446139590296 0.0404812227963499 0.0 30217 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +293962 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.016102253661434 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0131092554497256 0.3180524283074206 0.0 0.0052782617607871 0.0733499665770099 0.0 887 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +294723 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0160857716585862 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.2159908053119969 0.0446401662952339 0.0 0.0021305442572147 0.2404281781300717 0.0 5163 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +295072 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0160777363135157 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0316800311254893 0.1281708518900828 0.0 0.0030098452883262 0.0851438760198939 0.0 3555 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +295542 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0160677520651817 0.7797302331085993 0.7763400818577846 0.8693461273411047 0.0699064461360958 0.0467761235673353 0.0 0.0024691358024691 0.1388532550338759 0.0 270 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +295776 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0160627854740223 0.9845127857250529 0.6347970925105053 0.6198216015396206 1.0 0.0044340558155446 0.0 0.009009009009009 1.0 0.0 407 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +296159 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0160545424621603 0.6561647292424944 0.8604147465201248 0.6198216015396206 0.112230917768503 0.0436001007095475 0.0 0.0028990870959782 0.0830517482543263 0.0 1351 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +296434 CD34 SELP CD34-SELP Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.016049016816048 0.9559599666576516 0.941479368642921 0.8875000050982297 1.0 0.0021392900294222 0.0 0.0032882011605415 1.0 0.0 2585 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +296542 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0160463689557826 0.8533682807143209 0.944024288971064 0.6198216015396206 0.0706049302656684 0.0484215930647349 0.0 0.006766917293233 0.2293011279562322 0.0 475 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +296902 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0160384842880397 0.2534163760166434 0.6580560501976399 0.2461374514707439 0.2100740470724093 0.1973932010691654 0.0 0.0005668934240362 0.0102907769244743 0.0 147 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +297307 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0160301296118549 0.7487535481622718 0.9460955677032749 0.6198216015396206 0.1027229557481577 0.0376195773145198 0.0 0.0095204513399153 0.3463903714428978 0.0 1418 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +297440 CD34 SELP CD34-SELP Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0160268328642858 0.9559599666576516 0.4623922682986163 0.7204611100467462 1.0 0.0053213839468185 0.0 0.0027757216876387 1.0 0.0 2702 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +297471 VWF SELP VWF-SELP Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0160261429816508 0.955713094717548 0.4623922682986163 0.7204611100467462 1.0 0.0053213839468185 0.0 0.0023551577955723 1.0 0.0 2702 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +297479 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.0160260202695474 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0186793449598515 0.1993723722552783 0.0 0.0016492578339747 0.0611037252052322 0.0 16371 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +297930 CD34 SELP CD34-SELP Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0160157836228053 0.9559599666576516 0.7760344326192508 0.6198216015396206 1.0 0.0036702914086929 0.0 0.0027904616945712 1.0 0.0 1971 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +297963 VWF SELP VWF-SELP Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0160150942157902 0.955713094717548 0.7760344326192508 0.6198216015396206 1.0 0.0036702914086929 0.0 0.0025367833587011 1.0 0.0 1971 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +297969 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.016014997921925 0.9184503888425788 0.4641352222874551 0.7204611100467462 0.1169448695751571 0.046975263367762 0.0 0.0015411882561454 0.2549731771125494 0.0 12977 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +298159 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0160106266477498 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0673400749834054 0.1370986982961073 0.0 0.0023242300987797 0.0748746311200254 0.0 5163 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +298200 VEGFC FLT1 VEGFC-FLT1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.016009787638573 0.8718210606749883 0.6593689120110077 0.6198216015396206 0.1796394187986057 0.026308073552735 0.0 0.0016750418760469 0.122083616378682 0.0 398 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +298427 A2M LRP1 A2M-LRP1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0160049633158038 0.7741139100414175 0.8604147465201248 0.6198216015396206 0.093381536992618 0.0436001007095475 0.0 0.005103082261686 0.1461908143106864 0.0 1633 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +299518 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0159798526731338 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0244483651952677 0.1993723722552783 0.0 0.0074324324324324 0.3248180745502025 0.0 370 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +299683 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0159760924105241 0.6593525851613742 0.6593689120110077 0.8824495942126559 0.018132161410931 0.2390217618875283 0.0 0.0010036705666437 0.09937875811783 0.0 5812 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +302263 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0159188606687375 0.6303642896310324 0.6331674633943454 0.8824495942126559 0.141548283585814 0.0326412663903893 0.0 0.0017076737783895 0.6919074035484125 0.0 5812 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +302330 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.015917132473195 0.8718210606749883 0.6593689120110077 0.6198216015396206 1.0 0.0045642085393754 0.0 0.0101495726495726 1.0 0.0 312 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +302350 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0159166198071579 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.016822895653248 0.2390217618875283 0.0 0.0002861230329041 0.0283305624613526 0.0 1165 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +302380 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0159160429844501 0.6659645551150886 0.8960994285623033 0.7917001487310438 0.1496557267835524 0.0229905310518441 0.0 0.000595238095238 0.0280637234983943 0.0 3360 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +303182 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Macrophages Pericytes -> Macrophages 0.015899500553615 0.7487535481622718 0.7757991160529997 0.8875000050982297 0.0637288077574987 0.0491709261488903 0.0 0.0084064171122994 0.3793603738958809 0.0 2125 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +303296 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0158971095051849 0.8023917560710954 0.8950084308969304 0.6198216015396206 0.0085367158000785 0.4247538686915498 0.0 0.0063743158456814 0.0657095271775806 0.0 1362 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +303699 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0158880404404121 0.7797302331085993 0.885766439573873 0.6198216015396206 0.1132020978253244 0.0331922776397286 0.0 0.0035428219346888 0.3932939379633309 0.0 2164 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +304167 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0158777155846319 0.9184503888425788 0.4638256179742202 0.7204611100467462 0.1169448695751571 0.0446401662952339 0.0 0.005038937242327 0.4560156335943076 0.0 2183 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +304263 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0158749836200573 0.9468422434493456 0.7154802332407408 0.7204611100467462 0.1120119983652299 0.0292771742399634 0.0 0.0028383550384012 0.3251596703729426 0.0 12977 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +304706 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0158647226257652 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0053032910137447 0.8672894033034337 0.0 0.0068404511000184 0.071625692373805 0.0 1803 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +304815 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0158624063803827 0.6249837837987587 0.4638256179742202 0.2461374514707439 0.0435116250366991 0.5131068416842878 0.0 0.0047867711053089 0.1156158806885532 0.0 383 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +305152 CCN1 CAV1 CCN1-CAV1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0158551393717399 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.2646489893253856 0.0124087765732037 0.0 0.01082910321489 0.5338706028972664 0.0 394 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +305191 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.015854235641821 0.9184503888425788 0.6580560501976399 0.6198216015396206 0.1169448695751571 0.0362497659817488 0.0 0.0070733863837312 0.2966533790673963 0.0 377 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +306367 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0158299365205228 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.1027229557481577 0.049767778498468 0.0 0.0009843563066951 0.3363993118553313 0.0 6003 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +306524 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.015826165406016 0.9845127857250529 0.7830372268649692 0.7827641335561659 1.0 0.0026038611777234 0.0 0.0135363790186125 1.0 0.0 394 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +307133 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0158114848104454 0.6249837837987587 0.7746834992804791 0.8693461273411047 0.0161757332769496 0.2295016807597237 0.0 0.0017402945113788 0.1195304929260735 0.0 1245 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +307431 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0158047775365502 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.149715856631667 0.0467761235673353 0.0 0.0036625708884688 0.2059667553107647 0.0 4232 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +307818 C1QB LRP1 C1QB-LRP1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.015795714933364 0.9256868304646206 0.2550748532138862 0.2461374514707439 1.0 0.0267255153180908 0.0 0.0066539923954372 0.4139402884842979 0.0 263 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +308534 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.015779787980679 0.4619393085577573 0.930308383061206 0.7204611100467462 0.0308750930304183 0.1615013370958009 0.0 0.0017801657172449 0.0672097295263654 0.0 1931 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +308672 CD48 CD2 CD48-CD2 B Cells B Cells B Cells -> B Cells 0.01577681012672 0.9426443637490616 0.937587088419394 1.0 0.0632786830726401 0.0275738893167071 0.0 0.0109308885754583 0.4559091963615287 0.0 1418 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +308871 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0157727381142989 0.8924110508951895 0.7447682696221608 0.7204611100467462 1.0 0.0032154705418133 0.0 0.0126625834422957 1.0 0.0 1321 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +309080 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0157678767915128 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.1357656553382984 0.0326667674102811 0.0 0.0023734177215189 0.0502425599142527 0.0 79 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +309369 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0157619343634628 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.0051524613572059 1.0 0.0 0.0011261261261261 0.0615449705121542 0.0 148 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +309611 CD34 SELP CD34-SELP Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0157572646078222 0.9559599666576516 0.7478729882108823 0.7827641335561659 1.0 0.0027351735586246 0.0 0.0038071065989847 1.0 0.0 394 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +309636 VWF SELP VWF-SELP Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0157565863288809 0.955713094717548 0.7478729882108823 0.7827641335561659 1.0 0.0027351735586246 0.0 0.0205353022611905 1.0 0.0 394 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +310290 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0157417582195111 0.7840818683779507 0.8818326005152037 0.7827641335561659 0.0032417203409647 0.8672894033034337 0.0 0.0047129391602399 0.0493487235756852 0.0 389 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +310459 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0157380662240886 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0526353932596327 0.12709315903692 0.0 0.0225962996663633 1.0 0.0 157 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +311129 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.015723401074191 0.4604235282221027 0.4630027772793905 1.0 0.454846709299195 0.0155837683010033 0.0 0.0010707814371798 0.252311082197426 0.0 94924 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +311559 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.015713744036997 0.6249837837987587 0.4638256179742202 0.2461374514707439 0.0411214967239829 0.5131068416842878 0.0 0.010752688172043 0.2597119196698879 0.0 155 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +311741 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0157095252262973 0.6342079770588467 0.6580560501976399 0.8824495942126559 0.0673400749834054 0.0606066271159369 0.0 0.0017577634552607 0.0497699384046394 0.0 11947 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +312767 C1QB LRP1 C1QB-LRP1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0156890682668701 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.0037630364713574 1.0 0.0 0.0036854661120626 0.0273359437366901 0.0 4087 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +313205 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0156794252857077 0.6160088550075702 0.9008184599638702 0.7917001487310438 0.0106340017102282 0.3180524283074206 0.0 0.0016504329004329 0.0229354290428934 0.0 3360 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +313422 CD34 SELP CD34-SELP Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0156749015028929 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0042829523358709 1.0 0.0 0.005083179297597 0.0614692034065749 0.0 2164 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +314110 CD34 SELP CD34-SELP Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0156603343574013 0.9559599666576516 0.7760344326192508 0.6198216015396206 1.0 0.0032078747392388 0.0 0.0025918944392082 0.5933745434835918 0.0 2122 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +314172 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0156587054307762 0.4601010570874773 0.7346293219749174 0.2461374514707439 0.0177188549930425 1.0 0.0 0.0026644804263168 0.0197630597614004 0.0 4879 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +314188 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0156583101084605 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0186793449598515 0.2295016807597237 0.0 0.0008646779074794 0.0429836872130996 0.0 1542 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +314418 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0156529677911741 0.4625081978296446 0.7763400818577846 0.2461374514707439 0.3558005706994493 0.0467761235673353 0.0 0.0009469696969696 0.0532533790612876 0.0 176 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +314733 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.0156456053857716 0.4625081978296446 0.885766439573873 0.7204611100467462 0.149715856631667 0.0331922776397286 0.0 0.0011504082422169 0.1277085318392401 0.0 16371 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +315187 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0156364574950051 0.7800321422220979 0.9015117569158254 0.6198216015396206 0.1357656553382984 0.0246995741084876 0.0 0.0007894736842105 0.076068334712028 0.0 475 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +315408 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0156317081985038 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0267593032157803 0.1281708518900828 0.0 0.0041496201052016 0.117386345782383 0.0 1711 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +315540 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.015628736645133 0.662063103571249 0.930308383061206 0.6198216015396206 0.0236359933700329 0.1615013370958009 0.0 0.0034420289855072 0.1299529784765651 0.0 345 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +316048 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0156172775513184 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.112230917768503 0.0350138403862125 0.0 0.0023606969537508 0.1378430563570496 0.0 5701 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +317684 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0155825363187324 0.4625081978296446 0.4642836810638544 0.2461374514707439 0.3558005706994493 0.0761275033764692 0.0 0.0024253603880576 0.2335857047528101 0.0 4879 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +318085 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0155740052462636 0.4619393085577573 0.930308383061206 0.2461374514707439 0.0835287751665837 0.1615013370958009 0.0 0.0037442396313364 0.141362868898228 0.0 1736 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +318213 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.015571559700228 0.8924110508951895 0.6632137581773894 0.6198216015396206 1.0 0.0038860320327025 0.0 0.002020202020202 1.0 0.0 135 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +318244 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0155710373299195 0.9097736029185508 0.4614667734221426 0.6198216015396206 0.0430965463818576 0.12709315903692 0.0 0.0058630952380952 0.2762042194699418 0.0 800 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +318971 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0155554306013814 0.8924110508951895 0.6631822525600675 0.6198216015396206 1.0 0.0038621268649178 0.0 0.000585251658213 0.3617547996318567 0.0 233 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +319118 CD34 SELP CD34-SELP CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0155520727509974 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.1173076386135379 0.04130664769978 0.0 0.0003050640634533 0.1164245447656217 0.0 3278 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +319604 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0155415496928728 0.8640667164982425 0.6331674633943454 0.6198216015396206 1.0 0.0041555861088636 0.0 0.0093673218673218 1.0 0.0 407 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +319710 VWF ITGA9 VWF-ITGA9 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0155391446924398 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.1263644540569636 0.0309945332907452 0.0 0.0040787276559634 0.2544264670088952 0.0 3321 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +320223 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0155281148383665 0.9356727248601746 0.8923034233058523 0.8875000050982297 1.0 0.00189193058407 0.0 0.0029013539651837 1.0 0.0 2585 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +321287 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0155060220964644 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.7029371915698084 0.0042655619249233 0.0 0.0002614379084967 0.0662060815871915 0.0 11475 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +322272 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0154861657788192 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0265972645862203 0.166956519448744 0.0 0.0017407605784681 0.0244829931593821 0.0 1867 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +322566 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0154801093078201 0.9184503888425788 0.8923034233058523 0.8875000050982297 1.0 0.00189193058407 0.0 0.0026434558349451 1.0 0.0 2585 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +322677 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0154777531574466 0.633566764858408 0.6572093097629401 1.0 0.0799339500711946 0.04130664769978 0.0 0.0001486844962191 0.0567439002485807 0.0 423716 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +323119 A2M LRP1 A2M-LRP1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0154681368003474 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.093381536992618 0.0416128058995347 0.0 0.0095313975448536 0.5654013287727608 0.0 1412 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +323433 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0154618029189521 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.1098969873322313 0.0416128058995347 0.0 0.0081155977830562 0.4814162612284275 0.0 1684 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +324997 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.015429512971494 0.8949858186325867 0.896164124004365 0.8875000050982297 0.001895566065636 1.0 0.0 0.0025089605734767 0.0345525388823657 0.0 2790 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +325061 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0154281833417684 0.6589792304505506 0.6207977546603366 1.0 0.0561415215593491 0.0587195251380622 0.0 0.0002408583946689 0.0169819410039713 0.0 423716 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +326359 VWF ITGA9 VWF-ITGA9 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.015400646997597 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0036144684673052 1.0 0.0 0.0031078401464307 0.0347021188347122 0.0 4768 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +326543 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0153970892331114 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.1661175896787547 0.0446401662952339 0.0 0.0026122894572676 0.2947922779976908 0.0 6412 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +328840 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0153508641656364 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.1468839381042521 0.0219439768073448 0.0 0.00485312899106 0.6663176386098788 0.0 1305 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +328966 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.015348285236285 0.7797302331085993 0.7763400818577846 0.8693461273411047 0.1132020978253244 0.0219439768073448 0.0 0.0021419009370816 0.2940755082260466 0.0 1245 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +329223 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.01534274763686 0.9303167350027568 0.8819126042133903 0.9429656149619918 0.0016860250240652 1.0 0.0 0.0035055350553505 0.0423912741909549 0.0 2710 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +330343 CCN1 CAV1 CCN1-CAV1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0153199517391937 0.9219165193585238 0.943345641464811 0.9429656149619918 0.4529166025129413 0.0034806998160403 0.0 0.0021044427123928 0.7790808936946734 0.0 2566 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +331714 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0152925604031901 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.4344545964241579 0.0155837683010033 0.0 0.0037037037037037 1.0 0.0 1323 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +331990 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0152862408259098 0.8718210606749883 0.878254460598671 0.9429656149619918 0.0017670878089588 1.0 0.0 0.0025215252152521 0.02986361425273 0.0 2710 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +332452 COL4A2 CD93 COL4A2-CD93 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0152774476517902 0.8840293712888387 0.7779918296243433 0.6198216015396206 0.5544396796022323 0.0053794918117879 0.0 0.0041583166332665 0.4488968591677963 0.0 1996 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +333945 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0152468612613457 0.9184503888425788 0.4641352222874551 0.7204611100467462 1.0 0.0040904475843412 0.0 0.010548523206751 1.0 0.0 474 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +334177 C3 LRP1 C3-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0152422284845949 0.6319926036888139 0.6207977546603366 0.8824495942126559 0.0616816618657801 0.0587195251380622 0.0 0.0006968341362697 0.168175757529561 0.0 5812 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +334251 MMRN2 CD93 MMRN2-CD93 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0152410950528493 0.9468422434493456 0.6587114738285964 0.6198216015396206 0.1120119983652299 0.0289462771086338 0.0 0.0013054830287206 0.2699650704863827 0.0 6894 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +334481 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0152368533010774 0.7941469661104034 0.773263018678637 0.6198216015396206 1.0 0.0032875740549697 0.0 0.0027177123951317 0.4385164408332166 0.0 4836 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +334504 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0152362654895537 0.8718210606749883 0.4630488285702799 0.7204611100467462 1.0 0.0043013567716651 0.0 0.0144163150492264 1.0 0.0 474 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +335162 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0152225225108566 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0110717612136884 0.3162217004298525 0.0 0.0003626341746446 0.0417670773416363 0.0 6894 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +336091 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0152041731340526 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.1027229557481577 0.0390724515618796 0.0 0.0009162085623854 0.5176753695373698 0.0 6003 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +336098 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0152040115388486 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.1027229557481577 0.0484993884807927 0.0 0.0331799002685078 0.4717013960683137 0.0 474 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +336388 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.015198025459525 0.9184503888425788 0.7754072541855492 0.6198216015396206 0.1169448695751571 0.0238720285974944 0.0 0.0021077988557663 0.5138050872853651 0.0 3321 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +337102 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0151826727102497 0.7158082793127664 0.9404022517663844 0.7204611100467462 0.0025256125075084 1.0 0.0 0.0027106849536756 0.030267487050114 0.0 2247 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +337624 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0151726738736661 0.6593525851613742 0.4630488285702799 0.2461374514707439 0.4518617096918393 0.0359289752254096 0.0 0.0018115942028985 0.4569718688914347 0.0 184 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +337979 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0151659143450384 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.4103175828613323 0.0155837683010033 0.0 0.0045351473922902 1.0 0.0 1323 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +338026 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0151651515133521 0.8023917560710954 0.9008184599638702 0.6198216015396206 0.0085367158000785 0.3180524283074206 0.0 0.0053397410225604 0.0742043201503304 0.0 1362 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +338386 VEGFC FLT1 VEGFC-FLT1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0151580575186997 0.8718210606749883 0.4630488285702799 0.7204611100467462 0.1796394187986057 0.0232163927704059 0.0 0.0024431210871888 0.4780356221238543 0.0 2183 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +339290 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.015140744703586 0.718867305289982 0.956444566971872 0.7204611100467462 0.0024319941937022 1.0 0.0 0.0090018656716417 0.0817099033577994 0.0 536 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +339964 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0151279599624207 0.7783550150988336 0.7779918296243433 0.8693461273411047 0.1928969878996252 0.0118035014556376 0.0 0.0020869565217391 0.2111959192727714 0.0 575 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +339973 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0151277022940173 0.4636527906642655 0.6593689120110077 0.2461374514707439 0.0666348171285698 0.2390217618875283 0.0 0.0 0.0 0.0 186 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +340034 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0151265006075614 0.9184503888425788 0.6571792026963191 0.6198216015396206 1.0 0.0032020139126304 0.0 0.0032051282051282 1.0 0.0 312 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +340210 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.015122399972694 0.9197297916541942 0.8587566561291643 0.9429656149619918 0.0055862851962672 0.287457858136305 0.0 0.0019939921276154 0.0606443185369482 0.0 3218 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +340422 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0151185071235104 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.0699064461360958 0.0761275033764692 0.0 0.0 0.0 0.0 800 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +340637 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.015113994545905 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.454846709299195 0.0118035014556376 0.0 0.0026530260501304 0.2517310865045867 0.0 11604 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +340761 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0151115856719207 0.4625081978296446 0.885766439573873 0.2461374514707439 0.3558005706994493 0.0331922776397286 0.0 0.0035991140642303 0.3995430110784496 0.0 1806 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +341981 CD48 CD2 CD48-CD2 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.015086777742346 0.928447473463448 0.6614977577544194 0.7917001487310438 1.0 0.0024251058581756 0.0 0.005625 0.9044517120937348 0.0 2400 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +342711 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0150722433502504 0.718867305289982 0.6331674633943454 0.6198216015396206 1.0 0.0041555861088636 0.0 0.0054721030042918 1.0 0.0 233 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +342931 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0150678799919039 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.0839650520556947 0.0627790816848129 0.0 0.0067128172855045 0.1347906852772379 0.0 1362 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +343219 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0150621423229929 0.662063103571249 0.6331674633943454 0.8824495942126559 0.0967042147306326 0.0326412663903893 0.0 0.0007204920853406 0.2454266643658973 0.0 5812 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +344239 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.015042397294892 0.6593525851613742 0.6593689120110077 0.8824495942126559 0.4518617096918393 0.0066828239855783 0.0 0.0008920288303717 0.1098762416494396 0.0 4671 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +345012 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Pericytes Macrophages -> Pericytes 0.0150272435125634 0.8949858186325867 0.8818326005152037 0.8875000050982297 0.001895566065636 0.8672894033034337 0.0 0.0047830773376448 0.0500831335502627 0.0 2474 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +345337 VWF SELP VWF-SELP Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0150210472321134 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0025256125075084 1.0 0.0 0.0002225189141076 0.0012512180308219 0.0 2247 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +345379 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0150203179856601 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0034559943126159 1.0 0.0 0.0012923904052936 0.0185566729689646 0.0 4836 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +346423 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0150006431348678 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.7029371915698084 0.0046263543438723 0.0 0.0006535102838101 0.2298926162743136 0.0 11604 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +346860 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Pericytes Mast Cells -> Pericytes 0.0149930959128021 0.8624864526942296 0.8818326005152037 0.8567148457705164 0.0020100505037262 0.8672894033034337 0.0 0.0081967213114754 0.1121871079966466 0.0 244 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +347316 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.014983772849065 0.718867305289982 0.7167436199046466 0.8293805866303694 1.0 0.0026482500471321 0.0 0.0011282180716809 1.0 0.0 9905 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +347431 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.014981745901211 0.2542249848376565 0.7283139964676212 0.2461374514707439 0.1711385759005754 0.1449812920932466 0.0 0.0025688324110131 0.2105612783495083 0.0 4879 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +347749 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.014975624365993 0.7797302331085993 0.657421674383923 0.7917001487310438 0.0699064461360958 0.0397596998227057 0.0 0.0031249999999999 0.2398022249690977 0.0 1280 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +348029 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0149708171702181 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.1468839381042521 0.040323117011325 0.0 0.0039682539682539 0.2760128028473811 0.0 714 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +348340 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.014965421869796 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.1194227711616854 0.0518891167572028 0.0 0.0015256445419637 0.0780845449670164 0.0 3646 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +348402 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0149643379110252 0.6160088550075702 0.8950084308969304 0.909150863993142 0.0052742025956585 0.4247538686915498 0.0 0.0100358002230177 0.1034538770070398 0.0 1549 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +348515 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0149620190409648 0.4625081978296446 0.657421674383923 0.6198216015396206 0.149715856631667 0.0397596998227057 0.0 0.0042918454935622 0.3293421115455419 0.0 233 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +349054 CD48 CD2 CD48-CD2 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.014951718885183 0.9426443637490616 0.8960994285623033 0.909150863993142 0.0632786830726401 0.0229905310518441 0.0 0.0087153001936733 0.4109007417324624 0.0 1549 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +349915 CD48 CD2 CD48-CD2 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.014935017418236 0.928447473463448 0.4603649459881741 0.2461374514707439 1.0 0.0105486447632276 0.0 0.0013054830287206 0.2424804699136742 0.0 383 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +350301 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0149273130223251 0.6593525851613742 0.6593689120110077 0.8824495942126559 0.0120646829101097 0.2390217618875283 0.0 0.0015991177281499 0.1583371468580315 0.0 12090 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +350845 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.014916782074239 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0161757332769496 0.1993723722552783 0.0 0.0022720271102895 0.0992939361372167 0.0 2164 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +351240 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0149086064030068 0.8771078809726828 0.8818326005152037 0.8875000050982297 0.0080232294691882 0.1993723722552783 0.0 0.0016726403823178 0.0730990605482806 0.0 2790 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +351600 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0149015547711003 0.7783550150988336 0.7779918296243433 0.909150863993142 0.0316800311254893 0.0627790816848129 0.0 0.0022727272727272 0.0498441585150389 0.0 5764 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +351884 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0148967337258787 0.8978557803479422 0.4642836810638544 0.7204611100467462 0.0477973731763516 0.0761275033764692 0.0 0.001896657781423 0.1826665211199373 0.0 9754 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +352183 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.0148910769236693 0.8721681415062816 0.885766439573873 1.0 0.0425206505665654 0.0331922776397286 0.0 0.0008216605368182 0.0912137595824957 0.0 12779 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +352320 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.014888727210612 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0131302879503246 0.2898144908728011 0.0 0.0005458419171376 0.0126770907137894 0.0 5163 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +353139 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0148730520451511 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0131302879503246 0.2879885658616873 0.0 0.0004611748429123 0.0169950291043071 0.0 1577 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +353211 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.014871548573761 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2966815529783992 0.0203874717835032 0.0 0.0025399913532209 0.1506063357488361 0.0 1542 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +353244 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0148710518124986 0.7797302331085993 0.7763400818577846 0.8693461273411047 0.0699064461360958 0.0293997450046583 0.0 0.0015964240102171 0.0984262284604593 0.0 1044 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +353782 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0148602360219234 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0186793449598515 0.1973932010691654 0.0 0.0009962143853357 0.0178299720148677 0.0 1673 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +353996 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0148563844454161 0.4625081978296446 0.4642836810638544 0.8293805866303694 0.149715856631667 0.040323117011325 0.0 0.0015985192663637 0.1111853693448813 0.0 9905 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +354628 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0148449579323498 0.7475533330314548 0.7763400818577846 0.6198216015396206 0.0029751676683741 1.0 0.0 0.0038659793814432 0.0613793048148662 0.0 388 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +354728 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0148433316631284 0.6593525851613742 0.8998347793593909 0.6198216015396206 0.4518617096918393 0.0064362797035136 0.0 0.0001233654083395 0.0446981276567557 0.0 1351 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +354864 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0148406921030866 0.6213271600240247 0.9694036398779844 0.6198216015396206 0.0052560850129547 0.5444650460041837 0.0 0.0027053140096618 0.0538627009632563 0.0 345 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +354910 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0148400291475832 0.9184503888425788 0.6571792026963191 0.6198216015396206 0.1169448695751571 0.0244129856070659 0.0 0.0025125628140703 0.0882389835717979 0.0 398 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +355734 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0148256565412695 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0035190936623492 1.0 0.0 0.0023885350318471 0.0177163097579384 0.0 157 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +356145 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.014818304249936 0.4625081978296446 0.657421674383923 0.2461374514707439 0.3558005706994493 0.0397596998227057 0.0 0.0067024128686327 0.5143211259390835 0.0 373 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +356303 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0148149012182994 0.743507317541692 0.878254460598671 0.7827641335561659 0.0020684923107111 1.0 0.0 0.0014492753623188 0.0171644527306253 0.0 460 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +356546 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0148103362433724 0.6160088550075702 0.9255624071030766 0.8693461273411047 0.0021291294377375 1.0 0.0 0.0041106719367588 0.0330804642771851 0.0 575 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +356686 C1QB LRP1 C1QB-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0148078478399052 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.0419710388788557 0.0587195251380622 0.0 0.0006437768240343 0.0548661161439193 0.0 1165 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +356859 CD34 SELP CD34-SELP Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0148045401469271 0.9559599666576516 0.4623922682986163 0.2461374514707439 1.0 0.0096770075292062 0.0 0.0012048192771084 1.0 0.0 2075 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +356881 VWF SELP VWF-SELP Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0148039028784629 0.955713094717548 0.4623922682986163 0.2461374514707439 1.0 0.0096770075292062 0.0 0.0039868565169769 1.0 0.0 2075 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +356943 MMRN2 CD93 MMRN2-CD93 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0148028431978403 0.9845127857250529 0.6587114738285964 0.6198216015396206 1.0 0.0026174949623928 0.0 0.0024570024570024 0.8160629065577218 0.0 407 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +357105 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0148001194373023 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.1671376945154473 0.0144359394371152 0.0 0.004506501182033 0.5528845788297057 0.0 1692 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +357841 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0147867524830537 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0799339500711946 0.0335947364052305 0.0 0.0 0.0 0.0 827 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +358575 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0147734345711923 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.0161757332769496 0.1973932010691654 0.0 0.0034619188921859 0.0628439730283923 0.0 2359 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +358924 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0147665141457511 0.7840818683779507 0.6580560501976399 0.6198216015396206 0.0032417203409647 1.0 0.0 0.0024552281917966 0.1334794200977867 0.0 1154 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +359137 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0147625312549474 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0548063857429699 0.1076178292491983 0.0 0.0070775785061499 0.5929646884135651 0.0 1323 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +359575 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.014754217234484 0.7800321422220979 0.6331674633943454 0.8693461273411047 0.1357656553382984 0.0176963220730796 0.0 0.0002173913043478 0.0397401083692472 0.0 575 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +359961 C1QB LRP1 C1QB-LRP1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0147467917358118 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.8040181448318822 0.0032275631628407 0.0 0.0086297071129707 0.3439065469282828 0.0 239 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +360154 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0147435991128039 0.6160088550075702 0.9008184599638702 0.8693461273411047 0.0021291294377375 1.0 0.0 0.0036363636363636 0.0293407312581642 0.0 575 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +360395 C1QB LRP1 C1QB-LRP1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0147392147828522 0.9256868304646206 0.6207977546603366 0.6198216015396206 1.0 0.0028784826949613 0.0 0.003391472868217 0.2884596056043583 0.0 129 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +360519 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0147367100935616 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.1132020978253244 0.040323117011325 0.0 0.0025967894239848 0.1806202760842635 0.0 1412 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +360690 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0147334576514926 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0168149984327668 0.1281708518900828 0.0 0.0042164147950237 0.0993510212449818 0.0 1711 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +360941 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0147286938402401 0.8924110508951895 0.6631822525600675 0.6198216015396206 1.0 0.0027830389352876 0.0 0.0006734006734006 0.2096098295292731 0.0 135 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +361117 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0147250736670395 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0033973231723341 1.0 0.0 0.0131673881673881 0.128753428760334 0.0 77 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +361430 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0147194275998855 0.6605327397359113 0.4642836810638544 0.2461374514707439 0.1468839381042521 0.0917308979735958 0.0 0.0109211775878442 0.6009451404628295 0.0 351 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +362378 CD48 CD2 CD48-CD2 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0147008059755319 0.9011089648206808 0.7763428264267787 0.6198216015396206 0.4567172527116189 0.0050968401714881 0.0 0.0027726432532347 0.7056207662996995 0.0 2164 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +362398 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0147005345017404 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0028649117803088 1.0 0.0 0.0073937153419593 0.1018236952540801 0.0 2164 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +363792 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0146740271205509 0.6605327397359113 0.8381155706134242 0.6198216015396206 1.0 0.0029095741067474 0.0 0.0158730158730158 0.5013640716182769 0.0 42 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +364455 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0146615808206925 0.7797302331085993 0.885766439573873 0.6198216015396206 0.0699064461360958 0.0331922776397286 0.0 0.0011820330969267 0.1312192540475868 0.0 1692 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +364938 C1QB LRP1 C1QB-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0146535112598917 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.8040181448318822 0.0028784826949613 0.0 0.0137195121951219 1.0 0.0 246 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +364951 A2M LRP1 A2M-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0146532231687844 0.8937519114898692 0.6207977546603366 0.6198216015396206 1.0 0.0028784826949613 0.0 0.0063472563472563 1.0 0.0 407 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +365537 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0146427159776823 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0208904415011529 0.1341680150528327 0.0 0.0019587206922762 0.0487749354568424 0.0 5701 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +365851 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0146369862734881 0.6160088550075702 0.6632137581773894 0.8824495942126559 0.0548063857429699 0.049767778498468 0.0 0.0010949133454295 0.3741816793761682 0.0 5812 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +366482 COL4A1 CD93 COL4A1-CD93 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0146250419027464 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.4857192596400828 0.0053794918117879 0.0 0.0032207271686229 0.2621221581405261 0.0 1996 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +366803 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0146192095754815 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0637288077574987 0.049767778498468 0.0 0.0003560408260147 0.1216753405744659 0.0 6894 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +367360 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0146090751802955 0.7324582304061453 0.62431395375366 0.6198216015396206 1.0 0.0034299077593249 0.0 0.0014814814814814 0.1532567049808429 0.0 135 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +367699 A2M LRP1 A2M-LRP1 Macrophages Pericytes Macrophages -> Pericytes 0.0146025887374308 0.919551140852988 0.9078204025796472 0.8875000050982297 0.037376181609614 0.0350138403862125 0.0 0.0041936135812449 0.2448685809929064 0.0 2474 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +367930 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Macrophages Macrophages -> Macrophages 0.0145983355723929 0.7487535481622718 0.7757991160529997 1.0 0.0338862305197021 0.0491709261488903 0.0 0.0076373992159183 0.3446565383846822 0.0 2458 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +368468 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0145881539237077 0.6593525851613742 0.878254460598671 0.6198216015396206 0.0201572483258557 0.1332188634280341 0.0 0.0140721196130167 0.5303803977040226 0.0 379 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +369504 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0145693699353784 0.662063103571249 0.6331674633943454 0.7917001487310438 0.585843718590581 0.0049190726392343 0.0 0.000548245614035 0.1108605649463789 0.0 570 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +370276 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0145564228411801 0.6160088550075702 0.9460955677032749 0.7917001487310438 0.0548063857429699 0.0376195773145198 0.0 0.0145236442946366 0.5284256346998392 0.0 917 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +370287 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0145562119822815 0.6593525851613742 0.7472387841445823 0.6198216015396206 0.4518617096918393 0.0068935067166085 0.0 0.001763668430335 0.1072416815994473 0.0 756 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +370467 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0145530627005596 0.8718210606749883 0.8331580262014722 0.8567148457705164 1.0 0.001526625481682 0.0 0.0022222222222222 1.0 0.0 225 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +370777 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0145469740111347 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.4344545964241579 0.0053794918117879 0.0 0.0044144981412639 0.476552058244488 0.0 2152 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +370925 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0145443622993247 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0028649117803088 1.0 0.0 0.001182931981411 0.0643105497979525 0.0 3945 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +371144 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0145402499273207 0.7745997874735252 0.878254460598671 0.6198216015396206 0.016822895653248 0.1332188634280341 0.0 0.0017346460384435 0.0653790815489056 0.0 3555 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +371181 COL4A2 CD93 COL4A2-CD93 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0145396078923128 0.8840293712888387 0.6587114738285964 0.6198216015396206 1.0 0.0026174949623928 0.0 0.0078624078624078 1.0 0.0 407 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +371233 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.0145386017864392 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0425206505665654 0.0761275033764692 0.0 0.0008009372160856 0.0771380142115528 0.0 13942 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +371957 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0145250429928049 0.6249837837987587 0.6580560501976399 0.9161861017439124 0.0411214967239829 0.0606066271159369 0.0 0.0044359949302915 0.1063587144048143 0.0 526 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +372957 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0145087616260053 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0323110954490285 0.12709315903692 0.0 0.010204081632653 0.4807035001652363 0.0 77 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +373456 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0144999171268171 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.293296467876477 0.0090444648829713 0.0 0.0039158100832109 0.5509547874647784 0.0 1362 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +373557 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0144978923169654 0.7797302331085993 0.7763400818577846 1.0 0.0699064461360958 0.0219439768073448 0.0 0.0011578803977659 0.1589729293932438 0.0 19576 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +374037 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0144892516431367 0.7797302331085993 0.4642836810638544 0.2461374514707439 0.1132020978253244 0.0917308979735958 0.0 0.0104166666666666 0.5731840877784055 0.0 752 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +374163 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0144871894790764 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.7696906278989153 0.0053794918117879 0.0 0.0018806744487678 0.2030217820391974 0.0 1542 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +374486 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0144810482222728 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0208904415011529 0.1281708518900828 0.0 0.0017540782318891 0.0362268476082681 0.0 5701 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +375942 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0144550711951041 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0561415215593491 0.0501711964086628 0.0 0.0024305555555555 0.041239500386557 0.0 3360 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +376359 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0144478559837621 0.8533682807143209 0.6587114738285964 0.7917001487310438 0.0706049302656684 0.0289462771086338 0.0 0.0005035008675343 0.0744143501533093 0.0 30217 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +376587 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0144439774185826 0.718867305289982 0.6331674633943454 0.6198216015396206 1.0 0.0032187363284526 0.0 0.0035714285714285 1.0 0.0 1673 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +376977 CD34 SELP CD34-SELP Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0144370291710051 0.9303167350027568 0.4623922682986163 0.7204611100467462 0.1314667522621683 0.0222228052993653 0.0 0.0015026585497418 0.4015306130926242 0.0 12977 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +377556 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.014426502561752 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.4103175828613323 0.0053794918117879 0.0 0.0048791821561338 0.3970972049996284 0.0 2152 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +377706 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0144240483526649 0.662063103571249 0.6331674633943454 0.8824495942126559 0.585843718590581 0.0041555861088636 0.0 0.0006957813677073 0.0883637498579616 0.0 11947 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +377923 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0144198447072037 0.6342079770588467 0.6580560501976399 0.8824495942126559 0.0673400749834054 0.0362497659817488 0.0 0.0013172490293954 0.0552445963565869 0.0 12020 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +378224 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0144147013712604 0.7158082793127664 0.7292496872084557 0.8293805866303694 0.0071496754272206 0.2898144908728011 0.0 0.0007984947914276 0.0185449130739139 0.0 9905 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +378556 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0144093095649635 0.6249837837987587 0.4638256179742202 0.2461374514707439 0.0244483651952677 0.5131068416842878 0.0 0.0123456790123456 0.2981877596209825 0.0 351 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +379340 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0143949336568539 0.4636527906642655 0.878254460598671 0.2461374514707439 0.0666348171285698 0.1332188634280341 0.0 0.0035522273425499 0.1338840062824652 0.0 1736 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +379384 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.014394222792147 0.6561647292424944 0.6207977546603366 0.9161861017439124 0.0142750905665976 0.166956519448744 0.0 0.0093704512372634 0.0913710589766133 0.0 458 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +379671 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0143894152122322 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0151307911035231 0.1281708518900828 0.0 0.0033661315380631 0.069520464960942 0.0 1931 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +380305 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0143784509145041 0.662063103571249 0.9015117569158254 0.6198216015396206 0.0967042147306326 0.0246995741084876 0.0 0.0017450404114621 0.1681402695998171 0.0 1361 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +380825 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0143688123159177 0.724503440376099 0.6176321640000088 0.6198216015396206 1.0 0.0031731220372828 0.0 0.0016094420600858 0.7214967628662353 0.0 233 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +380851 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0143684128019348 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0186793449598515 0.1615138601457002 0.0 0.0 0.0 0.0 3278 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +381565 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0143550796441038 0.6213271600240247 0.62431395375366 0.7917001487310438 0.2247035641022029 0.0126805820762719 0.0 0.0031014492753623 0.6318445652155189 0.0 2300 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +382682 VWF SELP VWF-SELP Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0143350447870106 0.9275752708651288 0.4623922682986163 0.7204611100467462 0.1263644540569636 0.0222228052993653 0.0 0.0018459232067924 0.3056654372755446 0.0 12977 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +382794 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0143329877414077 0.6593525851613742 0.878254460598671 0.6198216015396206 0.018132161410931 0.1332188634280341 0.0 0.0047881411517775 0.180465791805357 0.0 2541 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +382917 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.014331226271755 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0024635726452692 1.0 0.0 0.0166666666666666 0.1052844153924995 0.0 370 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +383048 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0143287832531147 0.7487535481622718 0.8628183098412396 0.6198216015396206 0.0637288077574987 0.0339152418223636 0.0 0.000478229185644 0.0365378135431166 0.0 1996 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +383696 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0143172705535567 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0028649117803088 0.8672894033034337 0.0 0.0043834015195791 0.0458981672701966 0.0 1711 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +383870 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.014314286030142 0.6589792304505506 0.8604147465201248 0.6198216015396206 0.0561415215593491 0.0436001007095475 0.0 0.0013775803931244 0.0316577787634126 0.0 1351 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +384109 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.014309891092289 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.0435116250366991 0.0606066271159369 0.0 0.0042955326460481 0.1029909495157075 0.0 97 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +384286 DLL1 NOTCH3 DLL1-NOTCH3 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0143070969466446 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.00263399584678 1.0 0.0 0.0010455876202425 0.0571433854190641 0.0 797 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +384854 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0142975463805047 0.7324582304061453 0.62431395375366 0.6198216015396206 0.2376713873232418 0.0126805820762719 0.0 0.0017688319609637 0.3603563244425026 0.0 1093 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +385235 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0142907050307816 0.9845127857250529 0.8347945881127203 0.8567148457705164 1.0 0.0012097093680331 0.0 0.0222222222222222 1.0 0.0 225 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +385374 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0142880998307666 0.724503440376099 0.6176321640000088 0.6198216015396206 1.0 0.0030676679668133 0.0 0.0015672287073065 1.0 0.0 1542 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +385608 C1QB LRP1 C1QB-LRP1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.014284116658207 0.8703788833238396 0.8604147465201248 0.6198216015396206 0.0419710388788557 0.0436001007095475 0.0 0.0048859343214181 0.1145472283871671 0.0 3441 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +385754 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0142814290930572 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0024635726452692 1.0 0.0 0.0114864864864864 0.0684859602348732 0.0 370 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +385790 THBS2 CD36 THBS2-CD36 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.0142808914492232 0.9197297916541942 0.8587566561291643 0.946515890536252 0.0039472834455595 0.287457858136305 0.0 0.0012669537452031 0.0385325224867163 0.0 11379 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +386117 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0142750372488042 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0673400749834054 0.0689186266365139 0.0 0.0002113718030014 0.0198781629588855 0.0 1577 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +386140 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0142747123616286 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0491302556793708 0.0518891167572028 0.0 0.0035885167464114 0.1836651261435891 0.0 209 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +386356 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0142711789575023 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.1027229557481577 0.0267210109213584 0.0 0.0059748903342913 0.6278043222679083 0.0 3005 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +386598 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0142668735130152 0.4625081978296446 0.657421674383923 0.6198216015396206 0.0141498126994191 0.3162217004298525 0.0 0.0078828828828828 0.9079259542129214 0.0 148 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +387476 CCN1 CAV1 CCN1-CAV1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0142512433980417 0.6213271600240247 0.942159351720962 0.6198216015396206 0.0023088899408624 1.0 0.0 0.0034680804064501 0.0511068452208273 0.0 1509 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +387718 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0142467919873348 0.9219165193585238 0.252518874138558 0.2461374514707439 0.4529166025129413 0.0322196586137726 0.0 0.0040321285140562 0.7056069620846002 0.0 2075 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +387957 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0142426416084811 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0425206505665654 0.0467761235673353 0.0 0.0034085566525622 0.1916821204011369 0.0 1418 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +388263 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0142376154068585 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.1740454925211078 0.0118035014556376 0.0 0.0001209189842805 0.0122367647704397 0.0 827 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +388560 COL4A2 CD93 COL4A2-CD93 Macrophages Pericytes Macrophages -> Pericytes 0.0142326720954914 0.9188764516910942 0.8817184225858201 0.8875000050982297 0.0090193130488293 0.1281708518900828 0.0 0.0030315278900565 0.0857572433450095 0.0 2474 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +388771 COL4A1 CD93 COL4A1-CD93 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0142290915088108 0.7766289238087107 0.6587114738285964 0.6198216015396206 1.0 0.0026174949623928 0.0 0.0112320112320112 1.0 0.0 407 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +388888 CD34 SELP CD34-SELP Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0142269987140936 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.0018206581062216 1.0 0.0 0.001865671641791 0.0225609491471893 0.0 536 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +389176 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0142216497502277 0.8284725546778968 0.956444566971872 0.8567148457705164 0.0012187708721425 1.0 0.0 0.0038496376811594 0.0444823003105274 0.0 276 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +389479 CD48 CD2 CD48-CD2 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0142155374138802 0.9011089648206808 0.6614977577544194 0.7917001487310438 0.4567172527116189 0.0038288178384739 0.0 0.0060975609756097 1.0 0.0 246 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +389889 CD34 SELP CD34-SELP Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0142088142558131 0.9559599666576516 0.6572093097629401 0.6198216015396206 1.0 0.002113171886167 0.0 0.0034941763727121 1.0 0.0 3005 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +389997 VEGFC FLT1 VEGFC-FLT1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0142067889079826 0.8718210606749883 0.777821334064334 0.6198216015396206 0.1796394187986057 0.0108892901157311 0.0 0.0035887692632467 0.4453273965624454 0.0 1579 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +391109 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0141864232383547 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0172764782878141 0.1341680150528327 0.0 0.0058236272878535 0.145016615288664 0.0 1803 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +392866 VEGFC FLT1 VEGFC-FLT1 Pericytes Macrophages Pericytes -> Macrophages 0.0141568281404744 0.8718210606749883 0.8998347793593909 0.8875000050982297 0.1796394187986057 0.0064362797035136 0.0 0.0018823529411764 0.6820198075965402 0.0 2125 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +393694 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0141413697036482 0.4630253981438691 0.4630027772793905 0.8293805866303694 0.7696906278989153 0.0058437228618857 0.0 0.0012821807168096 0.3890906250208927 0.0 9905 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +393750 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.014140654080068 0.8640667164982425 0.6331674633943454 0.6198216015396206 1.0 0.0023576674662702 0.0 0.0036149162861491 1.0 0.0 1971 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +393907 C1QB LRP1 C1QB-LRP1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0141380422237912 0.4601010570874773 0.7346293219749174 0.8767341187813953 0.0026949121497638 1.0 0.0 0.005484693877551 0.0406812269305586 0.0 2450 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +394529 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.014127141605772 0.6626993710110988 0.8604147465201248 0.6198216015396206 0.0515877972474039 0.0436001007095475 0.0 9.25240562546262e-05 0.0021691601863427 0.0 1351 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +395094 C3 LRP1 C3-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0141179100419548 0.7148920381722296 0.6207977546603366 0.6198216015396206 1.0 0.0028784826949613 0.0 0.0021459227467811 0.5552132492839784 0.0 233 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +395187 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0141162068830644 0.6593525851613742 0.6593689120110077 0.8824495942126559 0.4518617096918393 0.0045642085393754 0.0 0.00073488630061 0.0842263759315997 0.0 12020 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +396534 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0140930648183635 0.7160288858520609 0.4638256179742202 0.2461374514707439 0.0186793449598515 0.5131068416842878 0.0 0.0019413537320352 0.0441021438485653 0.0 5752 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +396757 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0140890666423143 0.6160088550075702 0.8628183098412396 0.7917001487310438 0.0548063857429699 0.0339152418223636 0.0 0.0019854680635349 0.1516943425432315 0.0 2152 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +396775 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0140888053692902 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.2247035641022029 0.0124087765732037 0.0 0.0150197628458498 0.7404685029562014 0.0 253 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +396884 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0140865029095355 0.6630837220165452 0.944024288971064 0.6198216015396206 0.0415873844357376 0.0484215930647349 0.0 0.0017447393465158 0.0591215590215304 0.0 1351 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +397046 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Pericytes B Cells -> Pericytes 0.0140837097980286 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.00263399584678 0.8672894033034337 0.0 0.0040600055050922 0.0555685936801446 0.0 1211 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +397752 A2M LRP1 A2M-LRP1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0140721914385782 0.919551140852988 0.6207977546603366 0.6198216015396206 0.037376181609614 0.0587195251380622 0.0 0.0010782058654399 0.1386363500670148 0.0 1739 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +397765 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0140718896773516 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0131302879503246 0.1886404570313 0.0 0.0004994019138755 0.0130609740493453 0.0 30400 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +397820 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.0140709825604045 0.4636527906642655 0.4630488285702799 1.0 0.0693389464442948 0.0521374123931907 0.0 0.000526737179217 0.0937108831767499 0.0 94924 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +397921 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0140690016769268 0.8771078809726828 0.7746834992804791 0.6198216015396206 0.0080232294691882 0.2295016807597237 0.0 0.0007014590347923 0.0481790545496508 0.0 594 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +398133 CCN1 CAV1 CCN1-CAV1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0140653670703884 0.9219165193585238 0.62431395375366 0.6198216015396206 0.2646489893253856 0.0082011408892332 0.0 0.0019262981574539 0.3230610961975335 0.0 398 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +398239 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0140636361818762 0.6342079770588467 0.896164124004365 0.6198216015396206 0.002196330917593 1.0 0.0 0.00576 0.0793247315507385 0.0 3125 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +398565 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0140583806621301 0.6160088550075702 0.6631822525600675 0.8824495942126559 0.0548063857429699 0.0390724515618796 0.0 0.0013138960145154 0.742376389800407 0.0 5812 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +399305 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0140456311084253 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0126216524880575 0.1281708518900828 0.0 0.0019489652401044 0.0459233012852234 0.0 3555 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +399529 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0140413066837288 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0637288077574987 0.0390724515618796 0.0 0.0002769206424558 0.1564654619060038 0.0 6894 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +399803 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0140365769518238 0.8840293712888387 0.8347945881127203 0.8567148457705164 1.0 0.0012097093680331 0.0 0.0102222222222222 0.6050059691224382 0.0 225 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +399997 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0140336770049062 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.0085570823799139 0.2295016807597237 0.0 0.00242656449553 0.1206260601503249 0.0 1305 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +400216 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0140297933340577 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0172764782878141 0.1281708518900828 0.0 0.0067942318358291 0.1403207661192749 0.0 1803 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +401009 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0140165212907362 0.4625081978296446 0.4642836810638544 0.2461374514707439 0.3558005706994493 0.040323117011325 0.0 0.0033178665868382 0.2307749613389419 0.0 13362 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +401243 A2M LRP1 A2M-LRP1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0140124091466954 0.919551140852988 0.7346293219749174 0.7204611100467462 0.037376181609614 0.0416128058995347 0.0 0.0042540792540792 0.2523514575530151 0.0 715 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +401545 CCN1 CAV1 CCN1-CAV1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0140076752558711 0.9219165193585238 0.943345641464811 0.9429656149619918 0.2646489893253856 0.0034806998160403 0.0 0.0012811867835468 0.4743052107988077 0.0 2966 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +402985 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0139833004161936 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0020251995753771 1.0 0.0 0.0037610143993122 0.0419954574478003 0.0 1692 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +403244 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0139786865832216 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0084812136822336 0.2295016807597237 0.0 0.0012636899747262 0.0867953582552428 0.0 1187 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +403507 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0139741440456438 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.1027229557481577 0.0292373734098458 0.0 0.0031458179126572 0.4803843221091481 0.0 2702 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +404597 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0139564687406659 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0186793449598515 0.0855781119790033 0.0 0.0008968035359682 0.045189879487901 0.0 15611 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +404606 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.013956346836392 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0117842887908422 0.1341680150528327 0.0 0.0013558815365233 0.0337633817275909 0.0 15611 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +405323 COL4A1 CD93 COL4A1-CD93 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0139448517460617 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.4857192596400828 0.0058437228618857 0.0 0.0016687389568745 0.4067357951162877 0.0 2183 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +405760 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.013937447461704 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.0704104148800194 0.0467761235673353 0.0 0.0025380710659898 0.1427298687530958 0.0 394 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +406099 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.013931715976063 0.7741139100414175 0.6207977546603366 0.8693461273411047 0.1671376945154473 0.0104714078116759 0.0 0.0020289855072463 0.278496055154767 0.0 575 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +406101 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0139316831700122 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.149715856631667 0.0219439768073448 0.0 0.0008646779074794 0.1187172528344449 0.0 1542 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +406668 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0139223309898996 0.6605327397359113 0.9130058539314824 0.6198216015396206 0.1468839381042521 0.0132636308162813 0.0 0.0 0.0 0.0 103 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +407103 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0139148122801129 0.4625081978296446 0.4642836810638544 0.2461374514707439 0.149715856631667 0.0917308979735958 0.0 0.0015646731571627 0.0860971926009287 0.0 5752 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +407325 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0139110212499036 0.6342079770588467 0.7746834992804791 0.8693461273411047 0.0073929685753755 0.2295016807597237 0.0 0.0013568521031207 0.0674499786457933 0.0 737 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +408280 C1QB LRP1 C1QB-LRP1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0138950714386545 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.0419710388788557 0.0350138403862125 0.0 0.0017053445850914 0.0599523695939658 0.0 3555 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +408820 CD34 SELP CD34-SELP Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0138864310383426 0.9559599666576516 0.4623922682986163 0.7204611100467462 1.0 0.0022515473538965 0.0 0.0137130801687763 1.0 0.0 474 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +408855 VWF SELP VWF-SELP Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0138858332903211 0.955713094717548 0.4623922682986163 0.7204611100467462 1.0 0.0022515473538965 0.0 0.0120828538550057 1.0 0.0 474 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +408887 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0138853724151357 0.9097736029185508 0.4614667734221426 0.2461374514707439 0.0430965463818576 0.1609352200462838 0.0 0.0072487375794103 0.1522813318431698 0.0 877 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +409209 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0138802718098648 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0683610513379333 0.0587195251380622 0.0 0.0028622832842656 0.2018078960331079 0.0 5095 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +409967 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0138675553281151 0.9356727248601746 0.7746834992804791 0.6198216015396206 0.1750253929104546 0.0090444648829713 0.0 0.0025860249102807 0.3638539087815112 0.0 1579 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +410358 COL4A2 CD93 COL4A2-CD93 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0138612668700065 0.8355319038299565 0.8817184225858201 0.8567148457705164 0.001123788079051 1.0 0.0 0.0090579710144927 0.0775060061246333 0.0 276 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +410447 CD48 CD2 CD48-CD2 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0138596332411528 0.9426443637490616 0.6614977577544194 0.7917001487310438 0.0632786830726401 0.0226890201466244 0.0 0.0006273525721455 0.0909285349125837 0.0 797 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +410800 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0138542122948263 0.8624864526942296 0.6580560501976399 0.6198216015396206 0.0020100505037262 1.0 0.0 0.0064102564102564 0.3503329090691857 0.0 78 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +410870 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0138527955863973 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.1194227711616854 0.0326412663903893 0.0 0.0002287980475899 0.0779372081608513 0.0 3278 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +411046 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0138501358241438 0.7160288858520609 0.4641352222874551 0.8293805866303694 0.0186793449598515 0.1370986982961073 0.0 0.0015143866733972 0.0487856790096783 0.0 9905 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +411165 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0138482006274222 0.4630253981438691 0.4630027772793905 0.8293805866303694 0.2545335314555431 0.0155837683010033 0.0 0.0011393636237321 0.3149724910688057 0.0 7197 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +412010 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0138344427243484 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0020251995753771 1.0 0.0 0.0005910165484633 0.00332327058541 0.0 1692 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +412029 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0138341669483807 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0561415215593491 0.0416128058995347 0.0 0.0015683173004497 0.0517871150548551 0.0 5163 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +412331 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0138290950834531 0.7835752212271604 0.8818326005152037 0.7827641335561659 0.0064863313435223 0.1993723722552783 0.0 0.0007246376811594 0.0316686923803886 0.0 460 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +412486 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0138263884320885 0.7783550150988336 0.944024288971064 0.6198216015396206 0.0316800311254893 0.0484215930647349 0.0 0.0018018018018018 0.0667666158271665 0.0 3441 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +412683 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0138228015464582 0.662063103571249 0.6331674633943454 0.8824495942126559 0.585843718590581 0.0032187363284526 0.0 0.0004683151359451 0.0922487599942747 0.0 4671 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +413170 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0138153144921887 0.8978557803479422 0.657421674383923 0.6198216015396206 0.0477973731763516 0.0397596998227057 0.0 0.0025839793281653 0.1982860774938276 0.0 129 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +413343 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0138124844961717 0.8640667164982425 0.7841656220878274 0.7827641335561659 1.0 0.001309307002134 0.0 0.0011104060913705 0.137145379252636 0.0 394 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +413814 C1QB LRP1 C1QB-LRP1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0138050094949668 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.0419710388788557 0.0416128058995347 0.0 0.0012715179968701 0.0503761022501792 0.0 1278 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +413867 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0138043034623169 0.8949858186325867 0.6580560501976399 0.6198216015396206 0.001895566065636 1.0 0.0 0.0001916810427448 0.0104208132322731 0.0 1739 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +414285 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0137978650716676 0.4625081978296446 0.7763400818577846 0.2461374514707439 0.3558005706994493 0.0219439768073448 0.0 0.0055432372505543 0.7610670892629466 0.0 902 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +414342 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0137970814563165 0.4625081978296446 0.885766439573873 0.7204611100467462 0.0704104148800194 0.0331922776397286 0.0 0.0022993621124462 0.2552556116786835 0.0 2247 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +414861 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0137890203968275 0.6319926036888139 0.6207977546603366 0.8824495942126559 0.011891719340537 0.166956519448744 0.0 0.0013380432455576 0.0188189599610388 0.0 4671 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +415196 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0137830830389772 0.4601010570874773 0.7346293219749174 0.8293805866303694 0.0587727051993296 0.0416128058995347 0.0 0.0007130237253912 0.0282491920566822 0.0 9905 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +416129 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0137672085288192 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0020491452254277 1.0 0.0 0.0028812056737588 0.0413695360359174 0.0 1692 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +416611 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0137589903049122 0.4636527906642655 0.878254460598671 0.7204611100467462 0.0023125636768155 1.0 0.0 0.0071517412935323 0.084701450508403 0.0 536 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +416830 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0137558067450765 0.6605327397359113 0.885766439573873 0.6198216015396206 0.1468839381042521 0.0127192475389894 0.0 0.0008795074758135 0.1326513074995967 0.0 379 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +417647 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0137423717919166 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0515877972474039 0.0350138403862125 0.0 0.0004604455358708 0.0161872276053487 0.0 5701 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +418013 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0137368035917641 0.7766289238087107 0.8347945881127203 0.8567148457705164 1.0 0.0012097093680331 0.0 0.0133333333333333 0.7362310632875552 0.0 225 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +418108 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0137352862249559 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.1928969878996252 0.0155837683010033 0.0 0.00125 0.3455574722899688 0.0 800 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +418240 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0137330543120184 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.2545335314555431 0.0118035014556376 0.0 0.0024702653247941 0.2499860206396598 0.0 1093 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +418539 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages B Cells Macrophages -> B Cells 0.0137276620768312 0.7487535481622718 0.9546923450729716 0.6198216015396206 0.0338862305197021 0.0445745465878424 0.0 0.0140088031149483 0.5188183879954313 0.0 1074 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +419277 VWF ITGA9 VWF-ITGA9 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0137152744176194 0.9011206516381156 0.9404022517663844 0.8875000050982297 0.0008850282134344 1.0 0.0 0.0017269468882372 0.0192830754843263 0.0 2790 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +420398 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0136969770833076 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.002196330917593 0.8672894033034337 0.0 0.0043290043290043 0.0453285796244192 0.0 2541 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +420718 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0136914493728424 0.9845127857250529 0.9003264838243337 0.9429656149619918 1.0 0.0007880862995141 0.0 0.0015588464536243 1.0 0.0 2566 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +420796 C1QB LRP1 C1QB-LRP1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0136901286140825 0.8703788833238396 0.6207977546603366 0.909150863993142 0.8040181448318822 0.0016667952436519 0.0 0.0019083969465648 0.3354501989978663 0.0 1572 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +420887 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0136885924349162 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.014525360548861 0.2390217618875283 0.0 0.0003598298985933 0.0356286710443802 0.0 5095 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +421363 A2M LRP1 A2M-LRP1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0136812516057642 0.4648000335061383 0.7346293219749174 0.8767341187813953 0.0021905373114471 1.0 0.0 0.0053231292517006 0.0630290504701803 0.0 2450 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +421529 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0136782954471303 0.6213271600240247 0.62431395375366 0.9161861017439124 0.2247035641022029 0.0082011408892332 0.0 0.0057667934093789 0.967153809066149 0.0 526 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +421908 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Pericytes Macrophages -> Pericytes 0.0136721174661724 0.8913986641324685 0.930308383061206 0.8875000050982297 0.0054950348959687 0.1615013370958009 0.0 0.0018694421988682 0.0705803416692913 0.0 2474 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +421934 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0136714744019493 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0131302879503246 0.1347191569099048 0.0 0.0004943311380778 0.0214260277675218 0.0 5701 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +423040 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0136537074954283 0.7487535481622718 0.8622452992050237 0.6198216015396206 0.0637288077574987 0.0254056950469408 0.0 0.00136636910184 0.2146983411469561 0.0 1996 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +423063 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0136532995823981 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0515877972474039 0.0416128058995347 0.0 0.0011136935889986 0.0441232780447196 0.0 5163 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +423493 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0136465474449159 0.6342079770588467 0.6580560501976399 0.9161861017439124 0.0085570823799139 0.1973932010691654 0.0 0.0094614264919941 0.1693380180573618 0.0 458 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +423747 C1QB LRP1 C1QB-LRP1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0136422195668628 0.9256868304646206 0.6207977546603366 0.6198216015396206 1.0 0.0018097844702233 0.0 0.002906976744186 0.3207064825277107 0.0 129 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +424488 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0136306469301242 0.9470274865242416 0.7746834992804791 0.6198216015396206 0.0061455194924501 0.2295016807597237 0.0 0.0003128128128128 0.0214852540559253 0.0 1332 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +424495 VEGFC FLT1 VEGFC-FLT1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0136305406522269 0.8718210606749883 0.4630488285702799 0.2461374514707439 0.1796394187986057 0.0359289752254096 0.0 0.002008032128514 0.506523035397735 0.0 1909 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +424719 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.013626826155671 0.7463064942968751 0.8817184225858201 0.7827641335561659 0.0012430446376512 1.0 0.0 0.0065217391304347 0.0497752764385916 0.0 460 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +424790 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0136257740782739 0.2490567623945399 0.896164124004365 0.2461374514707439 0.011649387573427 1.0 0.0 0.0049833887043189 0.0686295088859518 0.0 1806 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +425098 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0136205872154195 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0018436902762588 1.0 0.0 0.0 0.0 0.0 262 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +426401 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0135991261400807 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.0699064461360958 0.040323117011325 0.0 0.0020794343938448 0.1446355298763569 0.0 6412 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +426614 VEGFC FLT1 VEGFC-FLT1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.013595443071321 0.8718210606749883 0.7472387841445823 0.7827641335561659 0.1796394187986057 0.0068935067166085 0.0 0.0010548523206751 0.0641413855135935 0.0 316 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +427180 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0135872993732614 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0065101973396288 0.2390217618875283 0.0 0.0003379805661174 0.0334652524892024 0.0 3945 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +427375 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.013584282910141 0.7783550150988336 0.7779918296243433 1.0 0.1928969878996252 0.0053794918117879 0.0 0.000699836534532 0.0755484610693399 0.0 19576 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +427807 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.0135772847243913 0.7487535481622718 0.7754239189773715 0.946515890536252 0.0637288077574987 0.0178869147172998 0.0 0.0024668757285697 0.4217159564058235 0.0 11074 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +427847 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0135765704986729 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0069047442087267 0.1993723722552783 0.0 0.0020768431983385 0.076945431739922 0.0 2247 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +427939 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0135752419512528 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.0673400749834054 0.0238720285974944 0.0 0.0 0.0 0.0 827 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +428303 VWF SELP VWF-SELP Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0135692699671631 0.9011206516381156 0.8819126042133903 0.8875000050982297 0.0008850282134344 1.0 0.0 0.0039915281850765 0.0224442585284438 0.0 2790 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +428393 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0135678126280498 0.7296454584598743 0.8923034233058523 0.7204611100467462 0.7029371915698084 0.00189193058407 0.0 0.0005644090305444 0.2129767672370636 0.0 10040 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +428727 C1QB LRP1 C1QB-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0135628946981295 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.8040181448318822 0.0018097844702233 0.0 0.0104665071770334 1.0 0.0 209 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +428871 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0135607721889307 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.7696906278989153 0.0042738820064046 0.0 0.0025702331141661 0.2186633236726094 0.0 1673 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +429723 CD34 SELP CD34-SELP Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0135472062160365 0.9559599666576516 0.8347297932672282 0.8567148457705164 1.0 0.0009042150166242 0.0 0.0066666666666666 1.0 0.0 225 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +429758 VWF SELP VWF-SELP Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0135466230701087 0.955713094717548 0.8347297932672282 0.8567148457705164 1.0 0.0009042150166242 0.0 0.0147474747474747 1.0 0.0 225 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +430124 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0135406994688653 0.7797302331085993 0.885766439573873 0.6198216015396206 0.1132020978253244 0.0127192475389894 0.0 0.003117085525034 0.4701329799401255 0.0 1711 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +431349 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0135208733230088 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0587727051993296 0.0587195251380622 0.0 0.0006863941427699 0.0584981927769976 0.0 3278 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +431653 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0135160256610225 0.4625081978296446 0.4642836810638544 1.0 0.0704104148800194 0.040323117011325 0.0 0.0018857236557697 0.1311619356494016 0.0 22361 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +431692 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0135154750436431 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0526353932596327 0.0218093597373452 0.0 0.0153793574846206 0.8334894184023764 0.0 209 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +431727 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0135150287434157 0.6249837837987587 0.6580560501976399 1.0 0.0244483651952677 0.0606066271159369 0.0 0.0035975085910652 0.0862549202194051 0.0 1552 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +431730 C3 LRP1 C3-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0135149834847856 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0334108479684367 0.0587195251380622 0.0 0.0002575107296137 0.0621483072809925 0.0 1165 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +432265 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0135065840295562 0.8978557803479422 0.7763400818577846 0.6198216015396206 0.0477973731763516 0.0293997450046583 0.0 0.0012843311598498 0.0791843967199379 0.0 1687 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +432659 THBS2 CD36 THBS2-CD36 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0135003909782336 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0063387366560491 0.287457858136305 0.0 0.002051101734646 0.062381222686325 0.0 3555 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +432875 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0134973971999035 0.6342079770588467 0.6571792026963191 0.8824495942126559 0.0673400749834054 0.0244129856070659 0.0 0.0013392483468653 0.0470332173252874 0.0 11947 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +433009 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0134955013670816 0.4625081978296446 0.9130058539314824 0.7204611100467462 0.149715856631667 0.0132636308162813 0.0 0.0016600265604249 0.2154990012108407 0.0 10040 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +433017 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0134953762376311 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.0086134406931133 0.1449812920932466 0.0 0.0006964084785451 0.0570829996021679 0.0 10961 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +433126 MMRN2 CD93 MMRN2-CD93 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0134937460585568 0.9468422434493456 0.7779918296243433 0.6198216015396206 0.1120119983652299 0.0118035014556376 0.0 0.0042155977115326 0.3229767967554918 0.0 3321 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +433785 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0134831809208905 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0425206505665654 0.0397596998227057 0.0 0.0053235053235053 0.4085082947876522 0.0 407 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +434381 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0134732667667737 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.112230917768503 0.0144359394371152 0.0 0.0013957816377171 0.1712428582032046 0.0 4836 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +434425 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0134724950194367 0.6342079770588467 0.7746834992804791 1.0 0.0053032910137447 0.2295016807597237 0.0 0.0012259910093992 0.0609447906766853 0.0 19576 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +434544 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.013470534234284 0.9845127857250529 0.7461459456652184 0.7827641335561659 1.0 0.0010390313650636 0.0 0.0095177664974619 1.0 0.0 394 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +435547 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0134545969096879 0.662063103571249 0.6331674633943454 0.8824495942126559 0.0491302556793708 0.0326412663903893 0.0 0.0008573671597388 0.292051455432822 0.0 12101 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +435551 THBS2 CD36 THBS2-CD36 Macrophages Pericytes Macrophages -> Pericytes 0.0134544936624416 0.8858959974474152 0.8587566561291643 0.8875000050982297 0.0030563796158022 0.287457858136305 0.0 0.0020715440582053 0.06300294569335 0.0 2474 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +435783 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0134507204176029 0.6249837837987587 0.4638256179742202 0.2461374514707439 0.0161757332769496 0.5131068416842878 0.0 0.0079787234042553 0.1927117701805817 0.0 752 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +435965 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.013447636645663 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0085570823799139 0.1993723722552783 0.0 0.0036036036036036 0.1335107221000809 0.0 370 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +436055 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.013446242278081 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.1357656553382984 0.0125623889131764 0.0 0.000390625 0.1813608894415507 0.0 800 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +436290 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0134428171475786 0.7783550150988336 0.944024288971064 0.6198216015396206 0.0267593032157803 0.0484215930647349 0.0 0.00263319044703 0.0975741143120227 0.0 1633 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +437179 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0134290243048485 0.2491449441646273 0.8819126042133903 0.2461374514707439 0.0108445362943651 1.0 0.0 0.0011074197120708 0.0133916597374235 0.0 1806 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +437406 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0134252847167563 0.6160088550075702 0.8622452992050237 0.7917001487310438 0.0548063857429699 0.0254056950469408 0.0 0.0030838120986819 0.4845611197620927 0.0 2152 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +437763 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0134194728101871 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0020251995753771 1.0 0.0 0.001903409090909 0.0146134435152446 0.0 800 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +438425 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.013408896655765 0.8840293712888387 0.8817184225858201 0.9429656149619918 0.0061698665784747 0.1281708518900828 0.0 0.0013051584835301 0.0369209183405562 0.0 3218 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +438522 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0134074872005567 0.9356727248601746 0.8818326005152037 0.9429656149619918 0.1750253929104546 0.0042655619249233 0.0 0.0013205214654978 0.3344065609501392 0.0 2966 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +438739 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0134039289911018 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.293296467876477 0.0042655619249233 0.0 0.0013003901170351 0.3293085332522853 0.0 1538 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +439009 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.013399640543767 0.8978557803479422 0.4642836810638544 0.7204611100467462 0.0477973731763516 0.040323117011325 0.0 0.0009324009324009 0.0648533578718322 0.0 715 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +439146 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0133977277436223 0.6332974881236617 0.6252253442669611 1.0 0.0131302879503246 0.1112417752963437 0.0 7.037303717155307e-05 0.007606871175598 0.0 423716 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +439322 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0133949426005067 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0084812136822336 0.1993723722552783 0.0 0.0028625954198473 0.1251034221897032 0.0 262 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +439357 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0133944247594716 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.2966815529783992 0.0064028969591119 0.0 0.0020479302832244 0.2883122193856079 0.0 11475 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +439455 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.013393096226732 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0673400749834054 0.046975263367762 0.0 0.0 0.0 0.0 1577 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +439530 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0133920729214237 0.6593525851613742 0.878254460598671 0.6198216015396206 0.0120646829101097 0.1332188634280341 0.0 0.0053140096618357 0.2002858585170353 0.0 345 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +440037 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0133841673373661 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0015572459193676 1.0 0.0 0.0034398034398034 0.0384088183792854 0.0 370 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +440134 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0133825738168814 0.6303682835571691 0.8891607331132086 0.6198216015396206 0.0272543760657653 0.0606680526002441 0.0 0.0064242424242424 0.2124559823438834 0.0 6875 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +440366 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0133790598507937 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0097699360831605 0.1615013370958009 0.0 0.0008594983336256 0.0265456939623239 0.0 5701 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +440905 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.013370769969647 0.7797302331085993 0.4642836810638544 0.2461374514707439 0.0699064461360958 0.0917308979735958 0.0 0.0026605853287723 0.1464004967643818 0.0 877 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +440991 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0133692276790608 0.4630253981438691 0.8817184225858201 0.2461374514707439 0.0443339118517084 0.1281708518900828 0.0 0.0024769585253456 0.0700693322698065 0.0 1736 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +441507 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0133611059893979 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0012306151710811 1.0 0.0 0.0111940298507462 0.1541603147363545 0.0 536 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +441768 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0133572761456165 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0967042147306326 0.0176963220730796 0.0 0.0013858695652173 0.2533431908539511 0.0 2300 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +441831 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0133562989267355 0.4636527906642655 0.878254460598671 0.7204611100467462 0.014525360548861 0.1332188634280341 0.0 0.0028482651475919 0.1073515606240971 0.0 1931 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +442091 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0133519315982256 0.8771078809726828 0.6580560501976399 0.6198216015396206 0.0080232294691882 0.1973932010691654 0.0 0.0019694731659281 0.0357517094924131 0.0 1354 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +442173 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0133505039440265 0.7324582304061453 0.8818704453527788 0.7204611100467462 0.2376713873232418 0.0051192928876727 0.0 0.0014664410603496 0.2762697522452624 0.0 591 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +442376 CCN1 CAV1 CCN1-CAV1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.013347450259412 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.013905026986541 0.1449812920932466 0.0 0.0008058338695345 0.0660523469647473 0.0 10879 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +443208 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0133340824081952 0.4625081978296446 0.885766439573873 0.7204611100467462 0.149715856631667 0.0127192475389894 0.0 0.0004697542331262 0.0708504645398525 0.0 15611 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +443296 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.013332603073904 0.6249837837987587 0.6580560501976399 0.9161861017439124 0.0411214967239829 0.0362497659817488 0.0 0.0045289855072463 0.1544633836186824 0.0 460 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +443349 A2M LRP1 A2M-LRP1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0133317496406075 0.8937519114898692 0.2550748532138862 0.2461374514707439 0.3743986430148447 0.0267255153180908 0.0 0.0050855596298236 0.4423796747129452 0.0 1909 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +443682 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0133262994870183 0.7835752212271604 0.7746834992804791 0.6198216015396206 0.0064863313435223 0.2295016807597237 0.0 0.0025720164609053 0.1766565333487197 0.0 162 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +444102 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.013319803742945 0.9184503888425788 0.4641352222874551 0.2461374514707439 0.1169448695751571 0.0455121851821151 0.0 0.00261917234154 0.1917601963926198 0.0 1909 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +445649 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0132958893578501 0.7324582304061453 0.62431395375366 0.6198216015396206 0.2376713873232418 0.0082011408892332 0.0 0.0048558421851289 0.8143774073705458 0.0 659 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +445940 MMRN2 CD93 MMRN2-CD93 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0132913222710924 0.9468422434493456 0.4630027772793905 0.7204611100467462 0.1120119983652299 0.0155837683010033 0.0 0.0024659012098327 0.3353546575034854 0.0 12977 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +446256 CD48 CD2 CD48-CD2 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0132861912958579 0.928447473463448 0.7464347811605867 0.6198216015396206 1.0 0.0012805120781881 0.0 0.0041551246537396 1.0 0.0 361 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +446513 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0132818555907953 0.9845127857250529 0.4630027772793905 0.2461374514707439 1.0 0.0048929293424311 0.0 0.0055421686746987 1.0 0.0 2075 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +446728 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0132783739581007 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.1027229557481577 0.0215025911544899 0.0 0.001379449565978 0.1657211031128427 0.0 2702 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +446732 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0132782891213823 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0673400749834054 0.0446401662952339 0.0 0.000807024339854 0.0730343915723456 0.0 5163 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +447260 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0132705306706495 0.2490567623945399 0.8818326005152037 0.2461374514707439 0.011649387573427 0.8672894033034337 0.0 0.0012480798771121 0.0130685219481692 0.0 1736 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +447610 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0132650619119429 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0069047442087267 0.2295016807597237 0.0 0.0015999999999999 0.0795370148191194 0.0 6875 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +448816 CD34 SELP CD34-SELP Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.013245693024054 0.8532069650852002 0.8819126042133903 0.8567148457705164 0.00083777361258 1.0 0.0 0.0 0.0 0.0 276 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +449012 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0132426018831861 0.6303642896310324 0.956444566971872 0.6198216015396206 0.0014431743145616 1.0 0.0 0.0052702702702702 0.0478382248926324 0.0 370 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +449062 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0132416876510394 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0015572459193676 1.0 0.0 0.0004914004914004 0.0027631321034465 0.0 370 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +449131 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0132405303800031 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0435116250366991 0.0689186266365139 0.0 0.0008196219015228 0.0998691169928213 0.0 10879 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +449444 MMRN2 CD93 MMRN2-CD93 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.013235783335312 0.893316592628645 0.8817184225858201 0.8875000050982297 0.0007691101630988 1.0 0.0 0.0042114695340501 0.0251100748151896 0.0 2790 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +449750 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.013230991050087 0.8840293712888387 0.7461459456652184 0.7827641335561659 1.0 0.0010390313650636 0.0 0.0071065989847715 1.0 0.0 394 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +450291 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0132226932320907 0.8718210606749883 0.777821334064334 0.6198216015396206 1.0 0.001271575589586 0.0 0.0048189938881053 1.0 0.0 1418 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +451012 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0132114955814545 0.718867305289982 0.7841656220878274 0.7204611100467462 1.0 0.001309307002134 0.0 0.0024413323239969 0.2919962392904743 0.0 1321 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +451053 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0132108531672696 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0186793449598515 0.0826982152707935 0.0 0.0006485084306095 0.0240704454788121 0.0 1542 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +451593 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0132025584043786 0.7797135509308979 0.942159351720962 0.7827641335561659 0.0009209869688402 1.0 0.0 0.0028260869565217 0.0416462053183454 0.0 460 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +451771 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0131997177578453 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0361307801045652 0.0518891167572028 0.0 0.0064060205580029 0.2338886895696741 0.0 1362 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +452093 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0131942606482254 0.4625081978296446 0.657421674383923 0.6198216015396206 0.0704104148800194 0.0397596998227057 0.0 0.005816894284269 0.446369341368882 0.0 659 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +452613 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0131867072527041 0.6630837220165452 0.6587114738285964 1.0 0.0415873844357376 0.0289462771086338 0.0 7.61965898991645e-05 0.0112613901719992 0.0 423716 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +452702 VEGFC FLT1 VEGFC-FLT1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0131850004960837 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0012459853895406 1.0 0.0 0.0044179368235034 0.0523237127640003 0.0 1509 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +452933 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0131818726382729 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0425206505665654 0.0293997450046583 0.0 0.0012566760917373 0.0774793459096848 0.0 2122 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +452938 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0131817716343759 0.831981591331937 0.657421674383923 0.6198216015396206 0.0048935684578858 0.3162217004298525 0.0 0.0 0.0 0.0 78 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +453057 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0131796710491191 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0637288077574987 0.0267210109213584 0.0 0.0035112629034114 0.3689416715699694 0.0 2369 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +453155 COL4A2 CD93 COL4A2-CD93 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0131783714863035 0.8840293712888387 0.6587114738285964 0.6198216015396206 0.5544396796022323 0.0026174949623928 0.0 0.0052763819095477 0.7158237500722362 0.0 398 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +453483 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0131730451410134 0.6160088550075702 0.9460955677032749 0.9318789094584046 0.0255753403203798 0.0376195773145198 0.0 0.0039647976773725 0.1442544781887638 0.0 5010 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +453716 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0131694801730039 0.6213271600240247 0.62431395375366 0.7917001487310438 0.1339639999453202 0.0126805820762719 0.0 0.0002015316404675 0.0410571511712103 0.0 827 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +454237 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Macrophages Macrophages -> Macrophages 0.0131610691808492 0.8978557803479422 0.9130058539314824 1.0 0.0477973731763516 0.0132636308162813 0.0 0.0019663683211282 0.2552672465115885 0.0 2458 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +454423 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0131584624829129 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0338862305197021 0.049767778498468 0.0 0.0002352449160959 0.0803938851754234 0.0 1739 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +455627 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0131401409300249 0.9184503888425788 0.7754072541855492 0.6198216015396206 0.1169448695751571 0.009971631136135 0.0 0.0031665611146295 0.3844801907543571 0.0 1579 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +455975 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0131351141651554 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.0435116250366991 0.0362497659817488 0.0 0.0 0.0 0.0 81 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +456120 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.013133166490467 0.7797302331085993 0.885766439573873 0.6198216015396206 0.8713412494740926 0.0013756087909864 0.0 0.0027482269503546 1.0 0.0 1880 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +456160 VWF ITGA9 VWF-ITGA9 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0131325700073147 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.1263644540569636 0.0112932915661816 0.0 0.0052535404294198 0.1968393417941379 0.0 398 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +456327 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0131300567866474 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.1740454925211078 0.0155837683010033 0.0 0.0005707038681039 0.1577687888704994 0.0 1577 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +456549 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Pericytes Macrophages -> Pericytes 0.0131269594294058 0.7487535481622718 0.7754239189773715 0.8875000050982297 0.0338862305197021 0.0293031867940321 0.0 0.0041339016682589 0.51735966349545 0.0 2474 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +456743 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0131238574303809 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0073929685753755 0.1993723722552783 0.0 0.002272091722595 0.0841792383207567 0.0 4768 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +457270 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0131164402371358 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0411214967239829 0.0689186266365139 0.0 0.0039682539682539 0.4835229745282168 0.0 1323 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +457299 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.013115780606374 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.0208904415011529 0.0627790816848129 0.0 0.0011160714285714 0.0244399126448389 0.0 3360 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +457514 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0131126432878408 0.6342079770588467 0.6571792026963191 0.8824495942126559 0.0085570823799139 0.1615138601457002 0.0 0.0009916535823485 0.0947850001809729 0.0 12101 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +458532 COL4A1 CD93 COL4A1-CD93 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0130967202423153 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.0017253404164066 1.0 0.0 0.0099946695095948 0.0762814071220421 0.0 536 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +458611 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0130955889195532 0.718867305289982 0.7167436199046466 0.8293805866303694 0.0361307801045652 0.0326667674102811 0.0 0.0057077625570776 0.1140580514196103 0.0 219 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +458702 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0130942448702855 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.0198024073017111 0.0627790816848129 0.0 0.0033492822966507 0.0734545493905837 0.0 209 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +459754 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0130775001776949 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0425206505665654 0.040323117011325 0.0 0.0011102886750555 0.0772263800712879 0.0 2702 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +460149 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0130716296084312 0.6605327397359113 0.885766439573873 0.6198216015396206 1.0 0.0013756087909864 0.0 0.0 0.0 0.0 4880 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +460251 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0130698055096879 0.7800321422220979 0.6331674633943454 0.909150863993142 0.0213929720256037 0.0518891167572028 0.0 0.0013987682165163 0.0715908435397482 0.0 5764 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +460385 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.01306772231702 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.141548283585814 0.0125623889131764 0.0 0.0033257747543461 1.0 0.0 1323 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +460427 C3 LRP1 C3-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0130671566603152 0.7148920381722296 0.6207977546603366 0.6198216015396206 1.0 0.0018097844702233 0.0 0.0029629629629629 1.0 0.0 135 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +460772 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.013062252944936 0.4619393085577573 0.7167436199046466 1.0 0.1194227711616854 0.0125623889131764 0.0 0.0002357148876996 0.1094386219208211 0.0 94924 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +461651 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0130487016620236 0.4636527906642655 0.777821334064334 0.6198216015396206 0.0693389464442948 0.0318483483218543 0.0 0.0011203033436745 0.1417760344852498 0.0 11604 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +461806 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0130463523324794 0.6213271600240247 0.62431395375366 0.8693461273411047 0.1153131738111426 0.0126805820762719 0.0 0.0014492753623188 0.295254469726878 0.0 575 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +461850 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0130456676323277 0.8840293712888387 0.4630027772793905 0.2461374514707439 1.0 0.0048929293424311 0.0 0.0031807228915662 1.0 0.0 2075 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +462133 CD48 CD2 CD48-CD2 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0130411822999698 0.9011089648206808 0.4603649459881741 0.2461374514707439 0.4567172527116189 0.0105486447632276 0.0 0.0039893617021276 0.740984201943648 0.0 752 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +462161 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0130407017299373 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0637288077574987 0.0310998965832685 0.0 0.0022802580789788 0.4303146559643501 0.0 12977 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +462532 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0130348695410433 0.4625081978296446 0.9130058539314824 0.2461374514707439 0.3558005706994493 0.0132636308162813 0.0 0.0022522522522522 0.292379725967141 0.0 222 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +463076 CCN1 CAV1 CCN1-CAV1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.013026440226047 0.9219165193585238 0.252518874138558 0.2461374514707439 0.2646489893253856 0.0322196586137726 0.0 0.0023397939584424 0.4094549320948229 0.0 1909 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +463136 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.013025601847709 0.7487535481622718 0.7757991160529997 0.8875000050982297 0.0338862305197021 0.0279580382843415 0.0 0.0023949169110459 0.3358358275118075 0.0 2790 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +463478 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0130203388567935 0.7941469661104034 0.4614667734221426 0.6198216015396206 1.0 0.0021449819680126 0.0 0.0284327323162274 1.0 0.0 103 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +463618 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.013018110085617 0.8684504425765611 0.7779918296243433 0.909150863993142 0.0126216524880575 0.0627790816848129 0.0 0.0015118469316942 0.0303572814945227 0.0 5764 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +463968 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0130127628571811 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0012306151710811 0.8672894033034337 0.0 0.0033185840707964 0.0347485682297815 0.0 452 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +464085 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0130108929646571 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0265972645862203 0.0587195251380622 0.0 0.0004252573054902 0.1026327009159612 0.0 30217 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +464921 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0129977395998982 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0073929685753755 0.1973932010691654 0.0 0.0019444444444444 0.0348011337110193 0.0 2400 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +465206 C1QB LRP1 C1QB-LRP1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0129933820043267 0.7452691992612583 0.7346293219749174 0.7204611100467462 0.0012199377895337 1.0 0.0 0.0069124423963133 0.0512711637234347 0.0 1302 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +465264 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0129924712540482 0.8533682807143209 0.7779918296243433 0.8693461273411047 0.0706049302656684 0.0118035014556376 0.0 0.0007453416149068 0.0707213766439839 0.0 575 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +465696 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0129862313865592 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.4344545964241579 0.0058437228618857 0.0 0.0021971496437054 0.6667471417452916 0.0 1684 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +465925 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0129829078600043 0.9845127857250529 0.7154802332407408 0.7204611100467462 1.0 0.0009436211854823 0.0 0.010900140646976 1.0 0.0 474 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +466336 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0129768861043128 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0411127335336962 0.0326412663903893 0.0 0.0010411460936198 0.4218467833068525 0.0 6003 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +466734 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.01297074325756 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.0051524613572059 0.1993723722552783 0.0 0.001865671641791 0.0815350662032394 0.0 536 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +466852 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0129688675719909 0.6332974881236617 0.8794572885381431 0.6198216015396206 0.0131302879503246 0.104965956217838 0.0 0.0011439337864208 0.0256382516600615 0.0 1351 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +468002 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0129518227539856 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0491302556793708 0.0326667674102811 0.0 0.0 0.0 0.0 5 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +468245 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0129484222544599 0.7766289238087107 0.7461459456652184 0.7827641335561659 1.0 0.0010390313650636 0.0 0.010514865844815 1.0 0.0 394 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +468656 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0129421691884254 0.2490567623945399 0.6580560501976399 0.2461374514707439 0.011649387573427 1.0 0.0 0.0 0.0 0.0 186 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +468841 CCN1 CAV1 CCN1-CAV1 B Cells Pericytes B Cells -> Pericytes 0.0129393106365948 0.6213271600240247 0.9694036398779844 0.6198216015396206 0.0023088899408624 0.5444650460041837 0.0 0.0024772914946325 0.0493227811993957 0.0 1211 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +468937 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0129380948867429 0.7941469661104034 0.4614667734221426 0.2461374514707439 0.0323110954490285 0.1609352200462838 0.0 0.0 0.0 0.0 19 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +469089 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0129359189535854 0.9470274865242416 0.6580560501976399 0.6198216015396206 0.0061455194924501 0.1973932010691654 0.0 0.0004688232536333 0.0085105159375399 0.0 1422 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +469305 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0129328353043099 0.6605327397359113 0.7467524951532132 0.6198216015396206 0.1468839381042521 0.0104195741475089 0.0 0.0144927536231884 1.0 0.0 23 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +469343 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Mast Cells Pericytes -> Mast Cells 0.012932298457863 0.7487535481622718 0.7754239189773715 0.8567148457705164 0.0637288077574987 0.0147571931436988 0.0 0.0208080808080808 0.4167037517123294 0.0 225 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +469761 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0129261309176139 0.9184503888425788 0.7746834992804791 0.6198216015396206 0.1169448695751571 0.0090444648829713 0.0 0.0034832172260924 0.395592118798981 0.0 1579 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +469831 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0129251977399086 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.1339639999453202 0.0124087765732037 0.0 0.0016181229773462 0.0797728373564634 0.0 103 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +470612 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0129134538223631 0.6301823358791634 0.6347970925105053 1.0 0.0208904415011529 0.0554888093272979 0.0 0.0001180035684279 0.0193121351787502 0.0 423716 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +471039 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.012906765419684 0.6301823358791634 0.7779918296243433 0.8693461273411047 0.0172764782878141 0.0627790816848129 0.0 0.007183908045977 0.1573143802426416 0.0 1044 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +471139 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0129053543693229 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0637288077574987 0.0292373734098458 0.0 0.0018115187606713 0.2766292379262356 0.0 2183 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +471551 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0128994088591965 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.0704104148800194 0.0293997450046583 0.0 0.000734214390602 0.0452673931774094 0.0 1362 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +471721 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0128970554726924 0.7487535481622718 0.8628183098412396 0.6198216015396206 0.0338862305197021 0.0339152418223636 0.0 0.0012243648607284 0.0935443012115579 0.0 594 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +472082 HSPG2 LRP1 HSPG2-LRP1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0128914711437494 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0012941512528773 1.0 0.0 0.0030380882472881 0.0297070515232189 0.0 4087 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +472126 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0128908731431945 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.013905026986541 0.1176565474247238 0.0 0.0020083463745435 0.1379527038380933 0.0 1278 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +472747 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0128815609001458 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.0839650520556947 0.0289462771086338 0.0 0.0010794896957801 0.1595419777567589 0.0 5095 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +472920 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0128789601744104 0.4625081978296446 0.885766439573873 0.2461374514707439 0.3558005706994493 0.0127192475389894 0.0 0.0013440860215053 0.2027211513804321 0.0 1736 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +472927 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0128788986960394 0.662063103571249 0.7167436199046466 0.6198216015396206 0.585843718590581 0.0026482500471321 0.0 0.0001936858415649 0.0722740679332871 0.0 5163 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +472948 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0128786853006199 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.4103175828613323 0.0058437228618857 0.0 0.003223617237869 0.7857193691042926 0.0 1684 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +473130 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0128760957518382 0.6589792304505506 0.6207977546603366 0.9161861017439124 0.0072827533047186 0.166956519448744 0.0 0.0086426491994177 0.0484841600657032 0.0 458 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +473317 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0128733356480411 0.6319926036888139 0.6207977546603366 0.8693461273411047 0.0265972645862203 0.0501711964086628 0.0 0.0035680076628352 0.102662502959571 0.0 1044 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +473578 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Macrophages Pericytes -> Macrophages 0.0128692849442857 0.9184503888425788 0.8818120773736414 0.8875000050982297 0.1169448695751571 0.0054043611446182 0.0 0.0018823529411764 0.3690748143917765 0.0 2125 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +473707 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.012867381458934 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0548063857429699 0.0279580382843415 0.0 0.0045672727272727 0.640462225959171 0.0 3125 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +473812 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0128658707268327 0.7941469661104034 0.8445107771175474 0.7917001487310438 1.0 0.0008542071298387 0.0 0.0030492898913951 0.5631869508150732 0.0 570 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +473939 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0128639446235352 0.8978557803479422 0.7763400818577846 0.6198216015396206 0.0477973731763516 0.0219439768073448 0.0 0.0008417508417508 0.115569446888077 0.0 594 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +474030 CD34 SELP CD34-SELP CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0128627553034289 0.633566764858408 0.6572093097629401 0.8824495942126559 0.0298399317533219 0.04130664769978 0.0 0.0006022023399862 0.2298242949236026 0.0 5812 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +474379 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0128574279633273 0.6582846571368821 0.6587114738285964 0.9161861017439124 0.4344545964241579 0.0026174949623928 0.0 0.0041825095057034 0.567422845883804 0.0 526 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +474995 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0128483667360132 0.8978557803479422 0.4642836810638544 0.2461374514707439 0.0477973731763516 0.0917308979735958 0.0 0.0025348542458808 0.1394820593833381 0.0 263 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +475244 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0128444976740098 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0015572459193676 1.0 0.0 0.0055008685581933 0.0422329767908961 0.0 157 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +475280 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0128438742040745 0.662063103571249 0.9015117569158254 0.6198216015396206 0.0491302556793708 0.0246995741084876 0.0 0.0012135922330097 0.1169335242337001 0.0 103 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +476332 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0128278639453935 0.8498991475190484 0.6207977546603366 0.7917001487310438 0.018166235813628 0.0587195251380622 0.0 0.0002357944203594 0.0200956660298119 0.0 30217 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +477783 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0128065211894525 0.9845127857250529 0.6347970925105053 0.6198216015396206 1.0 0.0011388334136451 0.0 0.0085470085470085 1.0 0.0 312 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +477904 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0128044359314905 0.724503440376099 0.2562573700401372 0.2461374514707439 1.0 0.0096442330625583 0.0 0.001086578581363 1.0 0.0 5752 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +478389 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0127971147714729 0.6561647292424944 0.6207977546603366 0.9161861017439124 0.0070489045197697 0.166956519448744 0.0 0.0131740196078431 0.1284595684955327 0.0 408 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +478917 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0127888775426048 0.6160088550075702 0.9255624071030766 0.7917001487310438 0.0009692519480124 1.0 0.0 0.0054764512595837 0.0440715175147856 0.0 83 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +479283 THBS2 CD36 THBS2-CD36 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0127837137861469 0.724503440376099 0.8587566561291643 0.7204611100467462 0.0009736808737186 1.0 0.0 0.0053638059701492 0.0770157321265673 0.0 536 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +479387 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0127821527735851 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.1836996873148393 0.0064028969591119 0.0 0.0031506338553318 0.3728197969758948 0.0 1490 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +480265 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0127690340969231 0.6160088550075702 0.8950084308969304 0.8693461273411047 0.0021291294377375 0.4247538686915498 0.0 0.0030041797283176 0.030968535962642 0.0 1044 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +480418 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0127670567121733 0.7766289238087107 0.4630027772793905 0.2461374514707439 1.0 0.0048929293424311 0.0 0.0040963855421686 1.0 0.0 2075 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +480858 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0127602678453675 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.0227314494836465 0.0467761235673353 0.0 0.0021810250817884 0.1226511849263244 0.0 917 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +481490 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0127509485689949 0.6630837220165452 0.6587114738285964 0.9161861017439124 0.4103175828613323 0.0026174949623928 0.0 0.0061108093427485 0.5956545028260665 0.0 526 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +481727 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Pericytes Macrophages -> Pericytes 0.012747548630938 0.8978557803479422 0.885766439573873 0.8875000050982297 0.0477973731763516 0.0127192475389894 0.0 0.000673672864457 0.1016063976199417 0.0 2474 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +481742 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0127472823054186 0.2542249848376565 0.62431395375366 0.2461374514707439 0.1711385759005754 0.0641739251983978 0.0 0.0025868440502586 0.2457377011761619 0.0 902 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +482209 VEGFC FLT1 VEGFC-FLT1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0127408229677418 0.8718210606749883 0.6593689120110077 0.6198216015396206 0.1796394187986057 0.0066828239855783 0.0 0.0025327142254115 0.3119687512166008 0.0 2369 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +482273 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.0127398400231885 0.7160288858520609 0.4638256179742202 1.0 0.0186793449598515 0.0689186266365139 0.0 0.0002212296152711 0.0208052270040057 0.0 94924 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +482528 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0127359677014418 0.2542249848376565 0.62431395375366 0.2461374514707439 0.1711385759005754 0.0638329144736252 0.0 0.0025089605734767 0.654985116831536 0.0 186 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +482844 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0127312493445436 0.6160088550075702 0.9008184599638702 0.7917001487310438 0.0009692519480124 1.0 0.0 0.0038335158817086 0.0309314937962574 0.0 83 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +482899 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0127305972947512 0.7797302331085993 0.7467524951532132 0.6198216015396206 0.1132020978253244 0.0104195741475089 0.0 0.005175983436853 0.3571428571428571 0.0 161 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +483386 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0127232682585607 0.4648000335061383 0.6207977546603366 0.2461374514707439 0.0357762282281787 0.166956519448744 0.0 0.006235827664399 0.0608054151144809 0.0 147 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +483439 COL4A2 CD93 COL4A2-CD93 Pericytes Mast Cells Pericytes -> Mast Cells 0.0127224356280624 0.8840293712888387 0.8347945881127203 0.8567148457705164 0.5544396796022323 0.0012097093680331 0.0 0.0097777777777777 0.5787013617692888 0.0 225 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +484085 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0127127654358404 0.9356727248601746 0.7470475610360806 0.7827641335561659 1.0 0.0007714919761827 0.0 0.0033840947546531 0.5196272239480377 0.0 394 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +484089 VWF LRP1 VWF-LRP1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0127126853527758 0.9011206516381156 0.7346293219749174 0.7204611100467462 0.0008850282134344 1.0 0.0 0.0014388036609689 0.0110464303914059 0.0 9754 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +485232 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.012696364302502 0.2534163760166434 0.4638256179742202 0.2461374514707439 0.2100740470724093 0.0689186266365139 0.0 0.0031427205028352 0.3829335465417155 0.0 4879 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +485500 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0126922416981706 0.8498991475190484 0.6207977546603366 0.8693461273411047 0.018166235813628 0.0501711964086628 0.0 0.0088601532567049 0.2110314878959594 0.0 1044 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +485550 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.012691612980103 0.8718210606749883 0.878254460598671 0.9429656149619918 1.0 0.0005788283879716 0.0 0.0009742790335151 1.0 0.0 2566 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +485870 C1QB LRP1 C1QB-LRP1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0126866532711814 0.7753420160918723 0.8604147465201248 0.8875000050982297 0.0161519521398178 0.0436001007095475 0.0 0.0017649903288201 0.041378933280015 0.0 2585 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +485971 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0126852675348504 0.718867305289982 0.9015117569158254 0.7204611100467462 0.0361307801045652 0.0246995741084876 0.0 0.0025380710659898 0.1291854336944417 0.0 591 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +486185 C3 LRP1 C3-LRP1 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0126819010462316 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0334108479684367 0.0350138403862125 0.0 0.0018565400843881 0.1630905883820773 0.0 3555 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +486713 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0126734636238812 0.9184503888425788 0.7470475610360806 0.7827641335561659 1.0 0.0007714919761827 0.0 0.0012690355329949 0.3681298400106931 0.0 394 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +486735 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0126731351170214 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.0051524613572059 0.2295016807597237 0.0 0.0006613756613756 0.0454259657182422 0.0 126 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +486940 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0126703476450235 0.8684504425765611 0.944024288971064 0.6198216015396206 0.0168149984327668 0.0484215930647349 0.0 0.0025369608958096 0.085966470370745 0.0 1633 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +487478 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0126628568942279 0.9845127857250529 0.8514619504364779 0.8567148457705164 1.0 0.0005740632036187 0.0 0.0059259259259259 1.0 0.0 225 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +487495 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0126626277797029 0.8771078809726828 0.4638256179742202 0.2461374514707439 0.0080232294691882 0.5131068416842878 0.0 0.0003168567807351 0.0076531078990176 0.0 263 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +487656 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0126605187648034 0.7324582304061453 0.943345641464811 0.7204611100467462 0.2376713873232418 0.0034806998160403 0.0 0.0010619852622453 0.3931551200364676 0.0 1538 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +487716 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0126598490364565 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0255753403203798 0.049767778498468 0.0 0.0003511509949278 0.120004262935675 0.0 1165 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +488612 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0126470835169453 0.7835752212271604 0.6580560501976399 0.6198216015396206 0.0064863313435223 0.1973932010691654 0.0 0.0041666666666666 0.0756372103948865 0.0 160 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +488635 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0126467067991613 0.7797302331085993 0.9130058539314824 0.6198216015396206 0.0699064461360958 0.0132636308162813 0.0 0.0 0.0 0.0 475 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +488737 A2M LRP1 A2M-LRP1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0126451251086587 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.2100317344087863 0.0064028969591119 0.0 0.0020860424794104 0.2936777398616129 0.0 1538 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +489174 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0126388579556522 0.4625081978296446 0.4642836810638544 0.8767341187813953 0.149715856631667 0.0144613249009303 0.0 0.0016986003533088 0.0098437882677268 0.0 2453 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +489214 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0126383034770082 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0338862305197021 0.0390724515618796 0.0 0.0005227664802132 0.2953730645362663 0.0 1739 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +489370 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0126358614213735 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0236359933700329 0.0518891167572028 0.0 0.0022668393782383 0.1160198961779235 0.0 193 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +489679 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0126310418240295 0.6605327397359113 0.657421674383923 0.9161861017439124 0.1468839381042521 0.0069492509109592 0.0 0.0018195050946142 0.3113655822815591 0.0 458 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +489805 CD34 SELP CD34-SELP Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0126291478451303 0.9559599666576516 0.6572093097629401 0.6198216015396206 1.0 0.0010419094417808 0.0 0.0016025641025641 0.1236476043276663 0.0 312 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +489836 VWF SELP VWF-SELP Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0126286042174611 0.955713094717548 0.6572093097629401 0.6198216015396206 1.0 0.0010419094417808 0.0 0.002039627039627 1.0 0.0 312 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +490257 COL4A1 CD93 COL4A1-CD93 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0126220277773815 0.7766289238087107 0.7779918296243433 0.6198216015396206 1.0 0.001079730675535 0.0 0.007052186177715 1.0 0.0 1418 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +490455 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0126188914148738 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.1468839381042521 0.0144613249009303 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +490683 COL4A1 CD93 COL4A1-CD93 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0126156043594468 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.4857192596400828 0.0026174949623928 0.0 0.0037688442211055 0.3673701640545354 0.0 398 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +490726 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0126149121987933 0.8640667164982425 0.2491073778594529 0.2461374514707439 1.0 0.0076066460958003 0.0 0.0023192771084337 0.9662285513048336 0.0 2075 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +491099 C1QB LRP1 C1QB-LRP1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0126093908153816 0.8703788833238396 0.6207977546603366 0.8693461273411047 0.0419710388788557 0.0203874717835032 0.0 0.0009328358208955 0.0528268792213474 0.0 737 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +491325 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0126062427774729 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.1153131738111426 0.0124087765732037 0.0 0.0 0.0 0.0 79 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +491334 A2M LRP1 A2M-LRP1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.012606072375783 0.7460047258226694 0.7346293219749174 0.7204611100467462 0.0010163752993685 1.0 0.0 0.0058243727598566 0.0689640749416071 0.0 1302 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +491498 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.012603348569486 0.6160088550075702 0.8628183098412396 0.8693461273411047 0.0255753403203798 0.0339152418223636 0.0 0.0007401011471567 0.0565454358069865 0.0 737 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +491750 C3 LRP1 C3-LRP1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0125997023570833 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0334108479684367 0.0416128058995347 0.0 0.0013302034428794 0.1242418474577659 0.0 1278 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +491803 MMP2 PECAM1 MMP2-PECAM1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0125988814986939 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0216588811659259 0.0518891167572028 0.0 0.0050189993666877 0.1832474894822357 0.0 1579 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +491865 A2M LRP1 A2M-LRP1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0125978790412342 0.919551140852988 0.9078204025796472 0.8875000050982297 0.037376181609614 0.0144359394371152 0.0 0.0015979689366786 0.1960484080334631 0.0 2790 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +492179 VWF ITGA9 VWF-ITGA9 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0125933007488661 0.9275752708651288 0.7831795333113832 0.7827641335561659 0.1263644540569636 0.0055509879377996 0.0 0.002301495972382 0.1716380180337438 0.0 316 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +492313 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0125916937525504 0.8721681415062816 0.9130058539314824 0.8875000050982297 0.0425206505665654 0.0132636308162813 0.0 0.0009026434558349 0.1171781029407961 0.0 2585 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +492496 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0125889671038249 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0069047442087267 0.1973932010691654 0.0 0.002027315407597 0.0362843354953009 0.0 1562 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +493427 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.0125752951782793 0.8721681415062816 0.885766439573873 0.946515890536252 0.0425206505665654 0.0127192475389894 0.0 0.0005419339719366 0.081736940199791 0.0 11379 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +493684 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0125713981927941 0.7766289238087107 0.8817184225858201 0.9429656149619918 0.0047694898966413 0.1281708518900828 0.0 0.0015315635265914 0.0360881004041662 0.0 3218 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +493924 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0125675586705264 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0073929685753755 0.1615138601457002 0.0 0.0008583690987124 0.0820452995128722 0.0 1165 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +493996 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0125663086555231 0.9184503888425788 0.7480927101953669 0.7827641335561659 0.1169448695751571 0.006260692484444 0.0 0.0031645569620253 0.3251050857827595 0.0 316 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +494835 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0125546829074003 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0425206505665654 0.0219439768073448 0.0 0.0008455944529003 0.116097161257429 0.0 1971 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +494917 COL4A1 CD93 COL4A1-CD93 Macrophages Pericytes Macrophages -> Pericytes 0.0125530524121572 0.9102252263107924 0.8817184225858201 0.8875000050982297 0.0042860632265532 0.1281708518900828 0.0 0.0022231204527081 0.0523831971151965 0.0 2474 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +495059 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0125507173590593 0.6319926036888139 0.8604147465201248 0.6198216015396206 0.0265972645862203 0.0436001007095475 0.0 0.0017894736842105 0.0511597119071359 0.0 475 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +495130 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0125497606556299 0.6213271600240247 0.8818704453527788 0.6198216015396206 0.2247035641022029 0.0051192928876727 0.0 0.0023512123438648 0.4429559900352459 0.0 1361 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +495162 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0125494232529687 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0616816618657801 0.0203874717835032 0.0 0.0012314126394052 0.1575117565884111 0.0 2152 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +495296 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0125475873983101 0.250044481781731 0.9003264838243337 0.2461374514707439 0.0070431301838115 1.0 0.0 0.0090439276485788 0.0571310781199609 0.0 1806 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +495311 CD34 SELP CD34-SELP CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0125473085224603 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0298399317533219 0.0335947364052305 0.0 0.0004347826086956 0.0365716200258686 0.0 2300 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +495649 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0125419837828005 0.6213271600240247 0.62431395375366 0.7917001487310438 0.1339639999453202 0.009460730808256 0.0 0.0002777777777777 0.0344877865728332 0.0 3360 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +495791 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0125398710985971 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.0084325366891025 0.1281708518900828 0.0 0.0040579710144927 0.1147937345119903 0.0 345 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +495817 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0125394795274163 0.8721681415062816 0.4642836810638544 0.2461374514707439 0.0425206505665654 0.0917308979735958 0.0 0.0010441767068273 0.0574565254254979 0.0 2075 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +496023 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0125363415548861 0.4625081978296446 0.7467524951532132 0.7204611100467462 0.149715856631667 0.0104195741475089 0.0 0.0015140045420136 0.1044663133989402 0.0 1321 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +496037 MMP2 PECAM1 MMP2-PECAM1 Pericytes Macrophages Pericytes -> Macrophages 0.0125360278163874 0.9067635403815892 0.9015117569158254 0.8875000050982297 0.0216588811659259 0.0246995741084876 0.0 0.0024470588235294 0.1245529960250222 0.0 2125 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +497862 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0125090246067287 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.1194227711616854 0.0176963220730796 0.0 0.0004632023440193 0.0846754722017957 0.0 11604 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +497890 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0125084880846864 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.2159908053119969 0.0046263543438723 0.0 0.0 0.0 0.0 827 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +498253 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0125033653833149 0.7158082793127664 0.7292496872084557 1.0 0.0025256125075084 0.2898144908728011 0.0 0.0005976314280951 0.0138798937741955 0.0 22361 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +498454 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0125004924636816 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0093830613230477 0.1449812920932466 0.0 0.0033970276008492 0.2784465312555231 0.0 157 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +498669 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0124972953581274 0.9184503888425788 0.8818326005152037 0.9429656149619918 0.1169448695751571 0.0042655619249233 0.0 0.0020791189031242 0.4515977251826502 0.0 2966 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +498704 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0124966924514622 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.7696906278989153 0.0026174949623928 0.0 0.0 0.0 0.0 233 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +498789 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0124954402260022 0.7797302331085993 0.885766439573873 0.6198216015396206 0.0699064461360958 0.0127192475389894 0.0 0.0004621926418931 0.0697099910459611 0.0 1803 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +499196 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0124894499996542 0.7482742921073442 0.8817184225858201 0.7827641335561659 0.005733874009046 0.1281708518900828 0.0 0.000771208226221 0.0218162899779489 0.0 389 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +499393 VWF ITGA9 VWF-ITGA9 Pericytes B Cells Pericytes -> B Cells 0.0124866013091928 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.1263644540569636 0.0083442542366581 0.0 0.0035918925853074 0.1977261513932658 0.0 1063 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +499399 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0124864879130191 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.112230917768503 0.0104714078116759 0.0 0.0004030632809351 0.0553239701896669 0.0 827 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +499478 COL4A2 CD93 COL4A2-CD93 Macrophages Macrophages Macrophages -> Macrophages 0.0124855851731709 0.9188764516910942 0.944024288971064 1.0 0.0090193130488293 0.0484215930647349 0.0 0.0017087062652563 0.0633169167994814 0.0 2458 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +499657 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0124830365162352 0.9184503888425788 0.896164124004365 0.9429656149619918 1.0 0.0004874986369898 0.0 0.0019485580670303 1.0 0.0 2566 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +500567 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0124703710138035 0.6213271600240247 0.62431395375366 0.8824495942126559 0.1339639999453202 0.0082011408892332 0.0 0.0004910577271839 0.082355707514147 0.0 11947 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +500722 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.0124680747303475 0.6303682835571691 0.4614667734221426 1.0 0.0101610580570933 0.12709315903692 0.0 0.001312328057935 0.0618223876998145 0.0 94924 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +500728 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0124680139481076 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0009153913192522 1.0 0.0 0.0008039868625125 0.0059633541512557 0.0 10961 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +501280 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0124597776422051 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0323110954490285 0.0218093597373452 0.0 0.0161608684924747 0.8758436686409005 0.0 193 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +501295 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0124595866891938 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0071496754272206 0.1886404570313 0.0 0.0002947765593679 0.0077093597066586 0.0 1542 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +501592 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0124551415875996 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0526353932596327 0.0312252462757311 0.0 0.0193744164332399 1.0 0.0 714 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +501726 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0124532828328969 0.6301823358791634 0.944024288971064 0.6198216015396206 0.0208904415011529 0.0484215930647349 0.0 0.0005551443375277 0.0124211410828119 0.0 1351 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +501908 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0124505586519814 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0255753403203798 0.0491709261488903 0.0 0.0045441335763916 0.2050652721063016 0.0 3441 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +502015 COL4A2 CD93 COL4A2-CD93 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.012449026280826 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0316800311254893 0.0289462771086338 0.0 0.0004291845493562 0.0913727354618278 0.0 1165 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +502443 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0124428303551489 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.1098969873322313 0.0104714078116759 0.0 0.0025181159420289 0.3456334970224342 0.0 2300 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +502632 A2M LRP1 A2M-LRP1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0124400523947844 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.3743986430148447 0.0028784826949613 0.0 0.0020938023450586 0.3384512749140007 0.0 398 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +503141 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0124328348991769 0.6582846571368821 0.944024288971064 0.6198216015396206 0.0198024073017111 0.0484215930647349 0.0 0.0 0.0 0.0 103 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +503738 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.012424260349842 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.4518617096918393 0.0043013567716651 0.0 0.0 0.0 0.0 103 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +503931 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0124215627222452 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.1132020978253244 0.0144613249009303 0.0 0.0104602510460251 0.0606196132738094 0.0 239 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +504219 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0124169798282525 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0053032910137447 0.1993723722552783 0.0 0.0026595744680851 0.0985351738903523 0.0 1692 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +504557 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0124123545776788 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0065101973396288 0.1332188634280341 0.0 0.0030196766023767 0.1138120852685665 0.0 1711 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +504659 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0124108448483864 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.454846709299195 0.0042738820064046 0.0 0.0027751686448638 0.2005714966571156 0.0 1673 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +505059 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0124057099911765 0.9184503888425788 0.896164124004365 0.9429656149619918 0.0004696576149175 1.0 0.0 0.0007380073800738 0.010163582865767 0.0 2710 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +505329 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0124015505106928 0.9356727248601746 0.7746834992804791 0.6198216015396206 0.1750253929104546 0.0046263543438723 0.0 0.0011793636454883 0.414877930335479 0.0 3321 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +505647 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0123970609177436 0.6605327397359113 0.657421674383923 0.9592803095773328 0.1468839381042521 0.0059327142047454 0.0 0.0041248606465997 1.0 0.0 1495 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +506901 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0123799596437929 0.7745997874735252 0.777821334064334 0.8693461273411047 0.0215813276111062 0.0318483483218543 0.0 0.0008695652173913 0.1100447561315611 0.0 575 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +507064 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0123774762537064 0.6605327397359113 0.657421674383923 0.9161861017439124 0.0227314494836465 0.0397596998227057 0.0 0.0009505703422053 0.0729436425761514 0.0 526 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +507147 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0123764946707273 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0012306151710811 1.0 0.0 0.0 0.0 0.0 148 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +507279 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0123744810933163 0.7205550478301406 0.944024288971064 0.7204611100467462 0.0151307911035231 0.0484215930647349 0.0 0.0 0.0 0.0 591 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +507301 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0123741617993814 0.8498991475190484 0.8604147465201248 0.6198216015396206 0.018166235813628 0.0436001007095475 0.0 0.0009210526315789 0.0215934188234137 0.0 475 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +507946 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0123644460160927 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0967042147306326 0.0125623889131764 0.0 0.0003306878306878 0.1535330280986672 0.0 1323 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +508127 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.012362043131953 0.7451589345683471 0.930308383061206 0.7827641335561659 0.0040724665904272 0.1615013370958009 0.0 0.0025706940874035 0.097055938464435 0.0 389 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +508284 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0123597764614081 0.255669001367946 0.9255624071030766 0.2461374514707439 0.0061207051981986 1.0 0.0 0.0090621403912543 0.0729272041407638 0.0 316 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +508811 C3 LRP1 C3-LRP1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0123521770313074 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0691889863216023 0.0144359394371152 0.0 0.0024376155268022 0.4162830488610493 0.0 2164 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +509014 CCN1 CAV1 CCN1-CAV1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.012349417499519 0.8619922139338987 0.7283139964676212 0.7204611100467462 0.0054092055025683 0.1449812920932466 0.0 0.0007620805139771 0.062465985145755 0.0 9754 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +510066 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0123342524435416 0.7487535481622718 0.7754239189773715 0.8875000050982297 0.0131092554497256 0.0521257226458961 0.0 0.004341164453524 0.1815577203837743 0.0 1424 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +511013 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0123207382116754 0.7840818683779507 0.8818326005152037 0.7827641335561659 0.0032417203409647 0.1993723722552783 0.0 0.0014492753623188 0.0536945295402499 0.0 460 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +511085 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.012319849961083 0.6249837837987587 0.6580560501976399 0.9592803095773328 0.0244483651952677 0.0362497659817488 0.0 0.0022853957636566 0.0779445997337351 0.0 1495 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +511346 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0123160162346234 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0435116250366991 0.0446401662952339 0.0 0.0007172665623369 0.0809422720191418 0.0 1278 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +511612 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0123122415498699 0.9219165193585238 0.7832252605020791 0.7827641335561659 0.4529166025129413 0.00136079311934 0.0 0.0016920473773265 0.2487325420518384 0.0 394 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +512147 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0123040818436798 0.255669001367946 0.9008184599638702 0.2461374514707439 0.0061207051981986 1.0 0.0 0.0060414269275028 0.0487464680713171 0.0 316 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +512380 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0123011081899749 0.7941469661104034 0.663300745568453 0.9161861017439124 0.0323110954490285 0.0222186841038061 0.0 0.0089869281045751 0.355370141335602 0.0 408 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +512638 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0122976549601339 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0053032910137447 0.1973932010691654 0.0 0.0015175861453311 0.0271613408717114 0.0 1867 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +512748 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0122963372206405 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.0693389464442948 0.026308073552735 0.0 0.0 0.0 0.0 233 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +513216 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0122894330848487 0.7487535481622718 0.8622452992050237 0.6198216015396206 0.0338862305197021 0.0254056950469408 0.0 0.0005356596265687 0.0841684967032904 0.0 594 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +513471 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0122857064594862 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0008193633790489 1.0 0.0 0.0012404749246854 0.019694747696518 0.0 1881 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +513477 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.012285658674164 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.0704104148800194 0.0219439768073448 0.0 0.001090909090909 0.1497780031669478 0.0 6875 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +513505 CD48 CD2 CD48-CD2 Plasma Cells B Cells Plasma Cells -> B Cells 0.0122853419506793 0.4593282471594782 0.937587088419394 0.6198216015396206 0.0467114894617178 0.0275738893167071 0.0 0.0015873015873015 0.0662037112586428 0.0 315 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +514045 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0122778695841627 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0515877972474039 0.0203874717835032 0.0 0.0003700657894736 0.0209569790595213 0.0 30400 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +514085 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0122774490386146 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.0200499113739789 0.0761275033764692 0.0 0.0022021042329336 0.2120839738794043 0.0 4087 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +514550 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.012270781075219 0.4625081978296446 0.4642836810638544 0.2461374514707439 0.0704104148800194 0.0917308979735958 0.0 0.0022100884035361 0.1216116005270876 0.0 12820 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +514758 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0122680921103148 0.9470274865242416 0.4638256179742202 0.2461374514707439 0.0061455194924501 0.5131068416842878 0.0 0.0022915269394142 0.0553477280181803 0.0 1491 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +514967 VEGFC FLT1 VEGFC-FLT1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0122654172983235 0.8317042416754105 0.878254460598671 0.8567148457705164 0.0005440770361181 1.0 0.0 0.0006038647342995 0.0071518553044272 0.0 276 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +515025 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0122647021443542 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.0179229861158654 0.0467761235673353 0.0 0.0 0.0 0.0 38 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +515154 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0122627991251527 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0637288077574987 0.0215025911544899 0.0 0.0014575438304251 0.1751030101938654 0.0 2183 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +515337 CCN1 CAV1 CCN1-CAV1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0122602764907745 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0083518627398662 0.1449812920932466 0.0 0.0009492406075139 0.0778070671027452 0.0 3336 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +516582 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.01224339990419 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0131302879503246 0.0741032966028748 0.0 0.0001116231602111 0.0025745260098149 0.0 5701 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +516807 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.012239754587151 0.6303682835571691 0.4614667734221426 0.2461374514707439 0.0291791383241764 0.1609352200462838 0.0 0.0048537005163511 0.1019664418666892 0.0 2075 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +517245 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0122339811833211 0.718867305289982 0.2491073778594529 0.2461374514707439 1.0 0.0076066460958003 0.0 0.0014690542420027 0.6199998532544735 0.0 5752 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +517875 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0122251959036739 0.6303642896310324 0.6331674633943454 1.0 0.0161193721503025 0.0518891167572028 0.0 0.0045188232361007 0.1649856780069528 0.0 4011 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +518243 A2M LRP1 A2M-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0122199432924885 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.0149044683666724 0.0587195251380622 0.0 0.0003934191702432 0.050586070394505 0.0 1165 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +518334 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0122187140630506 0.9468422434493456 0.6347970925105053 0.6198216015396206 0.1120119983652299 0.0079745943515326 0.0 0.0015557562983037 0.1864152764390867 0.0 3321 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +518355 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0122183653416823 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0361307801045652 0.0326412663903893 0.0 0.0004808635917566 0.194834097380743 0.0 5095 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +518513 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0122158558167219 0.7487535481622718 0.7757991160529997 0.8875000050982297 0.0131092554497256 0.0491709261488903 0.0 0.0051391726251276 0.2319178816063561 0.0 1424 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +518924 MMP2 PECAM1 MMP2-PECAM1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0122096109644244 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0216588811659259 0.0326667674102811 0.0 0.0048223350253807 0.0963645790775631 0.0 394 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +518975 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0122088833690875 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0265972645862203 0.0350138403862125 0.0 0.0003743760399334 0.0328876328296561 0.0 1803 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +519117 VWF ITGA9 VWF-ITGA9 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0122069145259582 0.9275752708651288 0.7292496872084557 0.7204611100467462 0.1263644540569636 0.0053724660607752 0.0 0.004614674665436 0.4457245704258931 0.0 394 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +519231 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.012205541071671 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0186793449598515 0.0606066271159369 0.0 0.0014306151645207 0.0405069455766896 0.0 233 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +519457 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0122022942346329 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0034559943126159 0.287457858136305 0.0 0.0005116061509676 0.0155597436695236 0.0 5701 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +519480 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0122019988476004 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0151307911035231 0.0627790816848129 0.0 0.0049559471365638 0.1085261319206946 0.0 1362 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +519525 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0122013016046319 0.6342079770588467 0.6580560501976399 0.8824495942126559 0.000895875398841 1.0 0.0 0.0006892748828232 0.0374726927438441 0.0 12090 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +519567 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0122005906307957 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0411214967239829 0.0446401662952339 0.0 0.0026722090261282 0.3015540961231385 0.0 1684 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +519984 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.012195105934713 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.0227314494836465 0.0761275033764692 0.0 0.000755857898715 0.0727964391740258 0.0 1323 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +520526 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0121874990841493 0.8640667164982425 0.930308383061206 0.9429656149619918 0.002676946692949 0.1615013370958009 0.0 0.0006991920447482 0.026397827887196 0.0 3218 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +520977 A2M LRP1 A2M-LRP1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0121813022091842 0.7741139100414175 0.6207977546603366 0.909150863993142 0.0149044683666724 0.0501711964086628 0.0 0.0022626069858894 0.060814236744888 0.0 5764 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +520989 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0121811035330568 0.6160088550075702 0.9008184599638702 0.8693461273411047 0.0021291294377375 0.3180524283074206 0.0 0.0023075583420411 0.0320672476914017 0.0 1044 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +521132 COL4A1 CD93 COL4A1-CD93 Pericytes Mast Cells Pericytes -> Mast Cells 0.012179138715203 0.7766289238087107 0.8347945881127203 0.8567148457705164 0.4857192596400828 0.0012097093680331 0.0 0.0098412698412698 0.5434086419503382 0.0 225 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +521642 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0121723151523889 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0069047442087267 0.1615138601457002 0.0 0.0003925417075564 0.037520225292442 0.0 5095 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +522016 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0121669425284005 0.7797302331085993 0.7763400818577846 0.909150863993142 0.0200499113739789 0.0293997450046583 0.0 0.0034430815579944 0.2122804028668188 0.0 1549 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +522279 CCN1 CAV1 CCN1-CAV1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0121633318231282 0.9219165193585238 0.62431395375366 0.6198216015396206 0.2646489893253856 0.0034299077593249 0.0 0.0007957559681697 0.0823195829141132 0.0 377 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +522409 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0121614166976179 0.7797302331085993 0.657421674383923 0.7917001487310438 0.0200499113739789 0.0397596998227057 0.0 0.0066666666666666 0.5115780799340752 0.0 50 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +522436 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0121611192153009 0.6249837837987587 0.7746834992804791 0.8693461273411047 0.1661175896787547 0.0046263543438723 0.0 0.0008695652173913 0.3058966749256153 0.0 575 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +522550 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0121594004089472 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0255753403203798 0.0390724515618796 0.0 0.0001560671088568 0.088180902871857 0.0 1165 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +522589 VWF LRP1 VWF-LRP1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0121588403745615 0.955713094717548 0.7769451595923457 0.7827641335561659 1.0 0.0005558995075445 0.0 0.0090274573142593 1.0 0.0 394 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +522730 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0121569384153807 0.7745997874735252 0.777821334064334 1.0 0.016822895653248 0.0318483483218543 0.0 0.0006914325224715 0.0875018018143345 0.0 21212 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +522829 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0121554948193068 0.9356727248601746 0.7746834992804791 0.6198216015396206 1.0 0.00071798405859 0.0 0.0015279736718382 1.0 0.0 1418 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +522838 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0121553279710563 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0799339500711946 0.0222228052993653 0.0 0.0003170577045022 0.0847220910541434 0.0 1577 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +523505 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0121458818079149 0.9219165193585238 0.8617632615906476 0.8567148457705164 0.4529166025129413 0.0010414441948928 0.0 0.0032592592592592 0.4118960178584288 0.0 225 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +523563 CD48 CD2 CD48-CD2 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0121449591377931 0.9011089648206808 0.7763428264267787 0.6198216015396206 0.4567172527116189 0.0016204239758814 0.0 0.0027556644213104 0.499533792508873 0.0 1633 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +524119 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.012136920577938 0.9468422434493456 0.7154802332407408 0.7204611100467462 0.1120119983652299 0.0058465532256424 0.0 0.0016032982134677 0.3374417830856285 0.0 2183 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +524287 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0121345509975674 0.7797302331085993 0.657421674383923 0.7917001487310438 0.1132020978253244 0.0069492509109592 0.0 0.0020488907729263 0.3506195560715276 0.0 2359 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +524323 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0121342461965145 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.0161757332769496 0.0606066271159369 0.0 0.0023712737127371 0.0568543534318418 0.0 246 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +524381 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0121336258973595 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.1496557267835524 0.0112209532878862 0.0 0.0 0.0 0.0 1577 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +524648 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0121297505793548 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0265972645862203 0.0416128058995347 0.0 0.0027760449157829 0.2592843604554187 0.0 6412 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +524821 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.012127395456917 0.9468422434493456 0.6347970925105053 0.6198216015396206 0.1120119983652299 0.0076236123034427 0.0 0.0037287181651892 0.3323001112020787 0.0 2369 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +524921 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0121259665722879 0.6342079770588467 0.4638256179742202 0.2461374514707439 0.0085570823799139 0.5131068416842878 0.0 0.0075973409306742 0.172590402801002 0.0 351 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +525487 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0121179158225047 0.9184503888425788 0.7746834992804791 0.6198216015396206 1.0 0.00071798405859 0.0 0.0021156558533145 1.0 0.0 1418 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +526000 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0121112715200277 0.6342079770588467 0.896164124004365 0.6198216015396206 0.000895875398841 1.0 0.0 0.0076335877862595 0.1051271357489643 0.0 262 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +526214 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0121084480113122 0.4625081978296446 0.7467524951532132 0.2461374514707439 0.3558005706994493 0.0104195741475089 0.0 0.0138888888888888 0.9583333333333331 0.0 84 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +526345 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.012106773714639 0.7158082793127664 0.7292496872084557 0.8293805866303694 0.0025256125075084 0.2879885658616873 0.0 0.0003157881440499 0.0116372971800283 0.0 7197 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +526434 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0121056755460371 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.2159908053119969 0.0042655619249233 0.0 0.0004781420765027 0.1210838684765745 0.0 4880 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +526496 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0121048509456285 0.7160288858520609 0.4641352222874551 1.0 0.0069047442087267 0.1370986982961073 0.0 0.0009391351012924 0.0302540588894597 0.0 22361 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +526588 COL4A2 CD93 COL4A2-CD93 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0121036657389254 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0267593032157803 0.0289462771086338 0.0 0.0004309252217997 0.0917433219681369 0.0 3945 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +526757 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes B Cells Pericytes -> B Cells 0.0121014138481185 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.1882781599600688 0.0049190726392343 0.0 0.0015286923800564 0.3091163824092824 0.0 1063 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +527263 C1QB LRP1 C1QB-LRP1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0120943235210312 0.9256868304646206 0.7769451595923457 0.7827641335561659 1.0 0.0005558995075445 0.0 0.0045391061452513 0.5726578906930292 0.0 179 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +527439 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0120918339751479 0.2534163760166434 0.6580560501976399 0.2461374514707439 0.2100740470724093 0.0362497659817488 0.0 0.0 0.0 0.0 26 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +527562 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0120902214564633 0.7487535481622718 0.7754239189773715 0.8875000050982297 0.0338862305197021 0.0178869147172998 0.0 0.0021831215379602 0.3732077691099683 0.0 2790 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +527748 CCN1 CAV1 CCN1-CAV1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0120875825781958 0.9219165193585238 0.62431395375366 0.6198216015396206 0.4529166025129413 0.0019304335593669 0.0 0.002844381758345 0.7022575829234776 0.0 1418 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +527856 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0120861391004708 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0492631209980634 0.0144359394371152 0.0 0.0027170344102968 0.2377589310111435 0.0 1692 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +527884 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0120856449562315 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.1932385901170197 0.0056518532344078 0.0 0.0013113618368962 1.0 0.0 1684 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +528118 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.012082275398327 0.9184503888425788 0.8818326005152037 0.9429656149619918 0.0004696576149175 0.8672894033034337 0.0 0.0004143360265175 0.0043384718845 0.0 3218 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +528178 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0120812575267073 0.6303642896310324 0.956444566971872 0.6198216015396206 0.0008320501336843 1.0 0.0 0.0047709923664122 0.0433062810977539 0.0 262 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +528283 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0120799118366932 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0006856224272495 1.0 0.0 0.0011240547721234 0.0192688990609052 0.0 1165 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +528369 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0120788367026308 0.8684504425765611 0.944024288971064 0.6198216015396206 0.0126216524880575 0.0484215930647349 0.0 0.0008095653256943 0.0274326158118712 0.0 3441 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +528402 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0120784514403014 0.6249837837987587 0.4638256179742202 0.2461374514707439 0.0084812136822336 0.5131068416842878 0.0 0.0 0.0 0.0 19 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +528653 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0120753095733573 0.8640667164982425 0.930308383061206 0.9429656149619918 1.0 0.0004089864655001 0.0 0.0009012081060015 1.0 0.0 2566 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +528828 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0120728872889523 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0093830613230477 0.1176565474247238 0.0 0.0027544351073762 0.189201312794207 0.0 714 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +529199 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0120678702087297 0.8516956437178343 0.896164124004365 0.8567148457705164 0.000472352586488 1.0 0.0 0.0144927536231884 0.1995891997552802 0.0 276 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +529409 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.012065216674535 0.6301823358791634 0.944024288971064 0.6198216015396206 0.0172764782878141 0.0484215930647349 0.0 0.0047368421052631 0.1059850206497613 0.0 475 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +530127 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0120549235274971 0.7856500335676843 0.9003264838243337 0.7827641335561659 0.0005542667491398 1.0 0.0 0.0054347826086956 0.0343318745845107 0.0 460 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +530412 CCN1 CAV1 CCN1-CAV1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0120510642663163 0.8749036366850302 0.942159351720962 0.8567148457705164 0.0004337320404416 1.0 0.0 0.0028985507246376 0.0427140567367645 0.0 276 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +530679 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0120472783016011 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.2545335314555431 0.0053794918117879 0.0 0.0011636363636363 0.1256163863691806 0.0 6875 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +531237 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.012040137898682 0.9184503888425788 0.6571792026963191 0.6198216015396206 0.1169448695751571 0.0069630688870869 0.0 0.0033769523005487 0.4264102623682481 0.0 2369 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +531450 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0120371365139394 0.8498991475190484 0.9078204025796472 0.6198216015396206 0.018166235813628 0.0350138403862125 0.0 0.0013519134775374 0.0475272957576741 0.0 1803 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +531730 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0120333664508154 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0172764782878141 0.0554888093272979 0.0 0.0005515658955775 0.0902677374700701 0.0 30217 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +531771 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0120327837914239 0.9845127857250529 0.4630027772793905 0.7204611100467462 1.0 0.0009242223287825 0.0 0.0121308016877637 1.0 0.0 474 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +531948 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.012030098552707 0.6332974881236617 0.6207977546603366 1.0 0.0131302879503246 0.0587195251380622 0.0 7.949149473189262e-05 0.0082668592758447 0.0 423716 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +532123 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0120276139997092 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0244483651952677 0.0689186266365139 0.0 0.0058386411889596 0.7114255230319623 0.0 157 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +532145 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0120272096843266 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.0051524613572059 0.1973932010691654 0.0 0.0023391812865497 0.0424629953094099 0.0 285 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +532408 A2M LRP1 A2M-LRP1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0120237627472075 0.8937519114898692 0.7769451595923457 0.7827641335561659 1.0 0.0005558995075445 0.0 0.00581641285956 1.0 0.0 394 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +532812 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0120180993123809 0.6561647292424944 0.6207977546603366 0.8824495942126559 0.0142750905665976 0.0587195251380622 0.0 0.0006886483210753 0.088546809819772 0.0 12101 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +533004 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0120154808913966 0.6213271600240247 0.62431395375366 0.8693461273411047 0.013905026986541 0.0641739251983978 0.0 0.0007236544549977 0.0687436810113271 0.0 737 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +533200 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0120130358920846 0.7856500335676843 0.8817184225858201 0.7827641335561659 0.0005542667491398 1.0 0.0 0.004891304347826 0.029163458770093 0.0 460 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +533209 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0120128116210454 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0561415215593491 0.0144359394371152 0.0 0.0007955380939251 0.0696149765617552 0.0 4836 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +533432 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0120095636727061 0.6160088550075702 0.8622452992050237 0.8693461273411047 0.0255753403203798 0.0254056950469408 0.0 0.0007401011471567 0.1162925071721369 0.0 737 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +533511 VWF ITGA9 VWF-ITGA9 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0120084259136142 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0036144684673052 0.2898144908728011 0.0 0.0009958742353108 0.0231290189048949 0.0 1278 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +533757 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0120051492400441 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0548063857429699 0.0310998965832685 0.0 0.0053597196454339 1.0 0.0 1323 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +534355 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0119968512096337 0.8818165186409654 0.7769451595923457 0.7827641335561659 1.0 0.0005558995075445 0.0 0.0075789622109419 1.0 0.0 394 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +534414 VWF ITGA9 VWF-ITGA9 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.011995783189998 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0036144684673052 0.2879885658616873 0.0 0.0003091861718573 0.0113940039664401 0.0 10879 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +534598 VWF LRP1 VWF-LRP1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.011992728380122 0.955713094717548 0.8755243548400705 0.8567148457705164 1.0 0.0004150165744076 0.0 0.0095454545454545 1.0 0.0 225 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +534633 COL4A2 CD93 COL4A2-CD93 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.011992270801346 0.8840293712888387 0.7461459456652184 0.7827641335561659 0.5544396796022323 0.0010390313650636 0.0 0.0022151898734177 0.3248420867856841 0.0 316 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +534889 C3 LRP1 C3-LRP1 Macrophages Pericytes Macrophages -> Pericytes 0.0119887849903644 0.9487258305485792 0.9078204025796472 0.8875000050982297 0.0110943464444434 0.0350138403862125 0.0 0.0024858528698464 0.2183735275008237 0.0 2474 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +534925 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0119882637335684 0.6605327397359113 0.657421674383923 0.9592803095773328 0.0179229861158654 0.0397596998227057 0.0 0.0046296296296296 0.3552625555097745 0.0 1476 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +534974 C1QB LRP1 C1QB-LRP1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0119874929302621 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.0419710388788557 0.0144359394371152 0.0 0.0008127097315436 0.0759466868804659 0.0 4768 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +534994 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.011987164882435 0.7797135509308979 0.9694036398779844 0.7827641335561659 0.0009209869688402 0.5444650460041837 0.0 0.0021422450728363 0.0426520194462069 0.0 389 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +537038 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0119591169142803 0.8498991475190484 0.7346293219749174 0.6198216015396206 0.018166235813628 0.0416128058995347 0.0 0.0018909856519026 0.0749187088097523 0.0 6412 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +537250 VEGFC FLT1 VEGFC-FLT1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0119563450789998 0.8718210606749883 0.6593689120110077 0.6198216015396206 0.1796394187986057 0.0045642085393754 0.0 0.0026525198938992 0.3040091202736086 0.0 377 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +537280 CD48 CD2 CD48-CD2 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0119558925669121 0.9011089648206808 0.7763428264267787 0.6198216015396206 0.4567172527116189 0.0014748371602574 0.0 0.0 0.0 0.0 151 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +537372 MMRN2 CD93 MMRN2-CD93 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0119545022153859 0.9845127857250529 0.6587114738285964 0.6198216015396206 1.0 0.0007261054236978 0.0 0.0096153846153846 1.0 0.0 312 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +537492 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.0119527466282463 0.7160288858520609 0.4641352222874551 1.0 0.0186793449598515 0.046975263367762 0.0 0.0003792507690362 0.0627429991877838 0.0 94924 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +538034 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0119447162211558 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0308750930304183 0.0518891167572028 0.0 0.001973201174743 0.1009910969562185 0.0 1362 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +538045 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.011944637713648 0.6213271600240247 0.62431395375366 0.7917001487310438 0.1153131738111426 0.0082011408892332 0.0 0.0020052083333333 0.3362951886572559 0.0 1280 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +538127 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0119433630186281 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0548063857429699 0.0178869147172998 0.0 0.00464 0.7932146784132845 0.0 3125 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +538444 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0119393629472117 0.7487535481622718 0.8950084308969304 0.6198216015396206 0.0016417770622885 0.4247538686915498 0.0 0.015712682379349 0.1619739207836737 0.0 162 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +538471 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0119390519187383 0.7160288858520609 0.4638256179742202 0.2461374514707439 0.0069047442087267 0.5131068416842878 0.0 0.0020800832033281 0.0472536906264834 0.0 12820 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +538661 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0119362262345872 0.9356727248601746 0.4638256179742202 0.7204611100467462 1.0 0.0009249287638231 0.0 0.0017580872011251 1.0 0.0 474 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +538785 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0119342269726172 0.6626993710110988 0.6207977546603366 0.8824495942126559 0.0135527119637784 0.0587195251380622 0.0 0.0005054198210598 0.043074589777763 0.0 5812 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +538930 C1QB LRP1 C1QB-LRP1 Pericytes Macrophages Pericytes -> Macrophages 0.0119322377672832 0.7753420160918723 0.8604147465201248 0.8875000050982297 0.0111808254589153 0.0436001007095475 0.0 0.0028529411764705 0.0668851611622716 0.0 2125 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +538978 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.011931686907268 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0491302556793708 0.0176963220730796 0.0 0.0 0.0 0.0 83 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +539176 C1QB LRP1 C1QB-LRP1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0119290929447932 0.9256868304646206 0.8755243548400705 0.8567148457705164 1.0 0.0004150165744076 0.0 0.0087121212121212 1.0 0.0 165 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +539322 CCN1 CAV1 CCN1-CAV1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.011926980156108 0.8619922139338987 0.7283139964676212 0.7204611100467462 0.0054092055025683 0.1176565474247238 0.0 0.0005128205128205 0.0352254856154012 0.0 715 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +539854 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.011919269791237 0.7800321422220979 0.6331674633943454 0.8693461273411047 0.1357656553382984 0.0049190726392343 0.0 0.0002314814814814 0.0468077940884711 0.0 270 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +539913 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.011918574021204 0.4636527906642655 0.4630488285702799 0.8293805866303694 0.0693389464442948 0.0232163927704059 0.0 0.0005384485949856 0.1053560588688918 0.0 9905 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +539944 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.011918170280268 0.7475533330314548 0.657421674383923 0.6198216015396206 0.0029751676683741 0.3162217004298525 0.0 0.0010109763142692 0.1164411102456779 0.0 1154 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +540552 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0119099017706483 0.662063103571249 0.6331674633943454 0.8824495942126559 0.0236359933700329 0.0326412663903893 0.0 0.0004394127377998 0.1496804818710919 0.0 12090 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +540795 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0119063879707843 0.7797302331085993 0.885766439573873 0.6198216015396206 0.0200499113739789 0.0331922776397286 0.0 0.0012149326264634 0.1348714798063665 0.0 1509 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +540909 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0119045835144621 0.6582846571368821 0.6587114738285964 0.8824495942126559 0.1740454925211078 0.0042738820064046 0.0 0.0005780346820809 0.0491764673348939 0.0 4671 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +540941 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0119039983866202 0.7941469661104034 0.8891607331132086 0.7917001487310438 0.0083898580598364 0.0606680526002441 0.0 0.0033191715347849 0.109768250078722 0.0 2152 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +541139 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0119010116300638 0.4625081978296446 0.9130058539314824 0.7204611100467462 0.0704104148800194 0.0132636308162813 0.0 0.000282007896221 0.0366093057894558 0.0 591 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +541223 C3 LRP1 C3-LRP1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0118999956246267 0.8509500867818902 0.7346293219749174 0.7204611100467462 0.0006305085967044 1.0 0.0 0.0043467819404418 0.0770041508184646 0.0 1041 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +541273 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0118993251117479 0.9184503888425788 0.4638256179742202 0.7204611100467462 1.0 0.0009249287638231 0.0 0.0066807313642756 1.0 0.0 474 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +541533 THBS2 CD36 THBS2-CD36 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0118957448256324 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0008527942416386 1.0 0.0 0.0017947868345482 0.0257702875240307 0.0 1509 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +541756 C1QB LRP1 C1QB-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0118928611038279 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0161519521398178 0.0587195251380622 0.0 0.0003019323671497 0.0257322968227319 0.0 6003 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +541913 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0118906444488689 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0053032910137447 0.1615138601457002 0.0 0.0004964093060197 0.0474481784752769 0.0 30217 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +542171 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0118870340829244 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0291791383241764 0.0373075519081129 0.0 0.0113490113490113 0.2141432311565414 0.0 407 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +542192 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0118868124844079 0.4636527906642655 0.777821334064334 0.6198216015396206 0.0693389464442948 0.0182001711419816 0.0 0.0005404236921746 0.0647278801678416 0.0 1542 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +542733 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0118791478571961 0.8023917560710954 0.4596166826058663 0.8293805866303694 0.0085367158000785 0.1076178292491983 0.0 0.0016294668232975 0.1365179187086823 0.0 7197 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +542812 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0118779429295835 0.6342079770588467 0.7746834992804791 0.8693461273411047 0.0028649117803088 0.2295016807597237 0.0 0.0001338688085676 0.0066547033817871 0.0 1245 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +543166 CD34 SELP CD34-SELP Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0118728539019514 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.0082993421103349 0.0741032966028748 0.0 0.0 0.0 0.0 1931 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +543175 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0118727831661519 0.7840818683779507 0.7746834992804791 0.6198216015396206 0.0032417203409647 0.2295016807597237 0.0 0.0051440329218106 0.2557131392075601 0.0 162 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +543405 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0118695421486353 0.7205550478301406 0.944024288971064 0.7204611100467462 0.0117842887908422 0.0484215930647349 0.0 0.0011454183266932 0.0256282946126304 0.0 10040 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +543429 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0118692764013854 0.7487535481622718 0.8950084308969304 0.6198216015396206 0.0015847932820241 0.4247538686915498 0.0 0.0171122994652406 0.1764018498618833 0.0 170 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +543437 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0118691739737197 0.6213271600240247 0.252518874138558 0.2461374514707439 0.2247035641022029 0.0322196586137726 0.0 0.0051612903225806 0.9032059301327108 0.0 155 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +543778 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0118645854010953 0.6332974881236617 0.863034163938375 0.6198216015396206 0.0131302879503246 0.0627102121186242 0.0 0.0043290043290043 0.0347742225642975 0.0 42 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +544117 A2M LRP1 A2M-LRP1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0118594961601747 0.8937519114898692 0.8755243548400705 0.8567148457705164 1.0 0.0004150165744076 0.0 0.0062962962962962 0.915824915824916 0.0 225 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +544357 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0118564346510365 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0048525806497539 0.166956519448744 0.0 0.0019866385372714 0.0279411530337985 0.0 1422 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +544411 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.011855756584479 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0515877972474039 0.0144359394371152 0.0 0.0002714019851116 0.0253621690278799 0.0 4836 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +544535 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0118542763459349 0.8571898293845529 0.9003264838243337 0.8567148457705164 0.0004196880356983 1.0 0.0 0.0084541062801932 0.0534051382425722 0.0 276 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +544671 CCN1 CAV1 CCN1-CAV1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0118524266999232 0.6213271600240247 0.62431395375366 0.7917001487310438 0.013905026986541 0.0649213179279442 0.0 0.0015138888888888 0.0623742009352863 0.0 2400 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +544798 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0118504877348612 0.4619393085577573 0.7167436199046466 0.8293805866303694 0.0308750930304183 0.0326667674102811 0.0 0.002283105022831 0.0483307425659173 0.0 219 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +545138 MMRN2 CD93 MMRN2-CD93 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0118457774384336 0.9845127857250529 0.8817184225858201 0.9429656149619918 1.0 0.0003375370073613 0.0 0.0015588464536243 1.0 0.0 2566 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +545411 C1QB LRP1 C1QB-LRP1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0118423371682395 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0161519521398178 0.0416128058995347 0.0 0.0010871576609918 0.0430719546455512 0.0 2702 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +545554 C1QB LRP1 C1QB-LRP1 Pericytes Pericytes Pericytes -> Pericytes 0.011840441601275 0.7753420160918723 0.9078204025796472 1.0 0.0111808254589153 0.0350138403862125 0.0 0.0005045963229416 0.0177393739149393 0.0 12510 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +545576 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0118401567617779 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.0085570823799139 0.0826982152707935 0.0 0.0022988505747126 0.0853255791455824 0.0 1305 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +545816 MMRN2 CD93 MMRN2-CD93 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0118373458959017 0.9468422434493456 0.7779918296243433 0.6198216015396206 0.1120119983652299 0.0053794918117879 0.0 0.00250501002004 0.3023851143678497 0.0 1996 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +546058 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0118340092533356 0.6342079770588467 0.4638256179742202 0.2461374514707439 0.0073929685753755 0.5131068416842878 0.0 0.000870322019147 0.0197712896159111 0.0 383 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +546135 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0118329522834173 0.8818165186409654 0.8755243548400705 0.8567148457705164 1.0 0.0004150165744076 0.0 0.0080246913580246 1.0 0.0 225 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +546425 CD48 CD2 CD48-CD2 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0118291402419524 0.4593282471594782 0.8960994285623033 0.6198216015396206 0.0467114894617178 0.0229905310518441 0.0 0.007380073800738 0.3479487489099818 0.0 271 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +546434 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0118290071967696 0.6319926036888139 0.6207977546603366 1.0 0.011891719340537 0.0587195251380622 0.0 8.93877030841403e-05 0.0215730600691793 0.0 423716 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +546459 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0118286032256131 0.6213271600240247 0.62431395375366 0.9161861017439124 0.2247035641022029 0.0034299077593249 0.0 0.0052173913043478 0.5397301349325336 0.0 460 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +546581 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0118265335206711 0.6605327397359113 0.885766439573873 0.6198216015396206 0.0227314494836465 0.0331922776397286 0.0 0.0009066666666666 0.1006504166246609 0.0 3125 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +546745 COL4A2 CD93 COL4A2-CD93 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0118242978503261 0.8840293712888387 0.4630027772793905 0.2461374514707439 0.5544396796022323 0.0048929293424311 0.0 0.0021477213200628 0.6944509137534313 0.0 1909 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +546832 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0118233334654036 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0069047442087267 0.0855781119790033 0.0 0.002071465561885 0.1043810325790668 0.0 1931 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +546893 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0118223836516752 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0213929720256037 0.0326412663903893 0.0 0.0001609442060085 0.0548236412770967 0.0 1165 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +547137 CCN1 CAV1 CCN1-CAV1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0118190753855275 0.6213271600240247 0.62431395375366 0.7917001487310438 0.013905026986541 0.0638329144736252 0.0 0.0003147353361945 0.0821642887208659 0.0 1165 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +547154 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0118188794116968 0.7797302331085993 0.657421674383923 0.7917001487310438 0.1132020978253244 0.0059327142047454 0.0 0.0 0.0 0.0 209 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +547170 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0118188077683486 0.8840293712888387 0.4630027772793905 0.7204611100467462 1.0 0.0009242223287825 0.0 0.0040084388185654 0.764412442414634 0.0 474 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +547464 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0118145160795849 0.4625081978296446 0.4642836810638544 0.2461374514707439 0.3558005706994493 0.0144613249009303 0.0 0.025735294117647 0.1491420779515928 0.0 272 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +547575 MMRN2 CD93 MMRN2-CD93 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0118130859058193 0.8571898293845529 0.8817184225858201 0.8567148457705164 0.0004196880356983 1.0 0.0 0.0172101449275362 0.1026121697466238 0.0 276 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +547815 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0118099036816121 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.0227314494836465 0.0293997450046583 0.0 0.0014251104460595 0.0878640295106622 0.0 2339 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +548739 A2M LRP1 A2M-LRP1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0117975519256473 0.919551140852988 0.6207977546603366 0.6198216015396206 0.037376181609614 0.0203874717835032 0.0 0.0009820426487093 0.0582292710105644 0.0 594 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +548808 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0117963897238731 0.8533682807143209 0.4630027772793905 0.6198216015396206 0.0706049302656684 0.0155837683010033 0.0 0.0001785714285714 0.0420772613606967 0.0 800 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +548880 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.011795513359007 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.000895875398841 0.8672894033034337 0.0 0.0004830917874396 0.0050584067117105 0.0 345 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +549198 C1QB LRP1 C1QB-LRP1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.01179126417556 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.0037630364713574 0.166956519448744 0.0 0.0017432851239669 0.0184712362120072 0.0 968 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +549223 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.01179099011894 0.8721681415062816 0.885766439573873 0.946515890536252 0.0110717612136884 0.0331922776397286 0.0 0.0003612064294744 0.0400980635449732 0.0 11074 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +549464 A2M LRP1 A2M-LRP1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.011787742380509 0.7741139100414175 0.8604147465201248 0.6198216015396206 0.0149044683666724 0.0436001007095475 0.0 0.0024096677322483 0.0690310815956129 0.0 3441 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +549553 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0117867212754403 0.9184503888425788 0.7754072541855492 0.6198216015396206 1.0 0.0006074333625108 0.0 0.0 0.0 0.0 1418 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +550652 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0117722771803781 0.6659645551150886 0.8581827408615759 0.7917001487310438 0.1496557267835524 0.003930762149527 0.0 6.578947368421052e-05 0.0176384510711623 0.0 30400 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +551153 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.01176598296443 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.112230917768503 0.0064028969591119 0.0 0.000503756830601 0.0709200166875731 0.0 4880 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +551155 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0117659676158805 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.1882781599600688 0.0041555861088636 0.0 0.0004711055276381 0.0598300744069823 0.0 398 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +551492 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0117615027990908 0.8949858186325867 0.8818326005152037 0.8875000050982297 0.001895566065636 0.1993723722552783 0.0 0.0019115890083632 0.0708228920100787 0.0 2790 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +551695 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0117586642763222 0.4625081978296446 0.885766439573873 0.7204611100467462 0.0704104148800194 0.0127192475389894 0.0 0.0009494217158639 0.1431960903588345 0.0 1931 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +552103 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Pericytes Mast Cells -> Pericytes 0.0117532435819347 0.8516956437178343 0.8818326005152037 0.8567148457705164 0.000472352586488 0.8672894033034337 0.0 0.0143442622950819 0.1501973632227171 0.0 244 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +552304 CD48 CD2 CD48-CD2 Macrophages B Cells Macrophages -> B Cells 0.0117508724818866 0.7719609236370527 0.937587088419394 0.6198216015396206 0.0212837736082081 0.0275738893167071 0.0 0.0041899441340782 0.1747556065346858 0.0 1074 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +552547 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0117478729886618 0.7797302331085993 0.7467524951532132 0.6198216015396206 0.0699064461360958 0.0104195741475089 0.0 0.0077519379844961 0.5348837209302326 0.0 129 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +553261 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0117378562000345 0.8640667164982425 0.8537710813834968 0.8567148457705164 1.0 0.0004138063814779 0.0 0.0022222222222222 0.1941747572815535 0.0 225 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +553316 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.011737089984071 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.0673400749834054 0.009971631136135 0.0 0.000595238095238 0.072273121571563 0.0 3360 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +553348 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0117366725953362 0.6342079770588467 0.7754072541855492 0.8693461273411047 0.0073929685753755 0.0826982152707935 0.0 0.0 0.0 0.0 737 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +553349 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0117366670456816 0.8978557803479422 0.7467524951532132 0.7827641335561659 0.0477973731763516 0.0104195741475089 0.0 0.0018621973929236 0.1284916201117318 0.0 179 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +553503 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0117347762015057 0.8624864526942296 0.8818326005152037 0.8567148457705164 0.0020100505037262 0.1993723722552783 0.0 0.002415458937198 0.1055623079346288 0.0 276 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +553755 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0117312998863629 0.6593525851613742 0.777821334064334 0.7917001487310438 0.0201572483258557 0.0318483483218543 0.0 0.0060240963855421 0.7623582503090081 0.0 83 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +553881 A2M LRP1 A2M-LRP1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.011729647616176 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.093381536992618 0.0064028969591119 0.0 0.0020336225596529 0.2862979459647607 0.0 922 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +553950 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0117284752917011 0.7296454584598743 0.8923034233058523 0.7204611100467462 0.293296467876477 0.00189193058407 0.0 0.0001410039481105 0.053207095228927 0.0 591 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +554135 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0117259750150298 0.9845127857250529 0.6347970925105053 0.6198216015396206 1.0 0.000671064546954 0.0 0.0030559473436765 1.0 0.0 1418 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +554220 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.01172484456861 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.1098969873322313 0.0064028969591119 0.0 0.001565995525727 0.2204643631029458 0.0 1490 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +554302 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0117236830829902 0.6332974881236617 0.6252253442669611 0.8824495942126559 0.0131302879503246 0.0565946652887153 0.0 0.0003697864969541 0.0136785027801213 0.0 4671 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +554474 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0117214892132849 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.0179229861158654 0.0761275033764692 0.0 0.0 0.0 0.0 77 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +554504 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0117210352857557 0.4630253981438691 0.8347945881127203 0.7204611100467462 0.7696906278989153 0.0012097093680331 0.0 0.0022181146025878 0.1312799257920584 0.0 1082 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +554733 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.0117180814937427 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0411127335336962 0.0176963220730796 0.0 0.0014961915125136 0.1981684098811253 0.0 4595 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +554738 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0117180606467554 0.7487535481622718 0.9546923450729716 0.6198216015396206 0.0131092554497256 0.0445745465878424 0.0 0.0030456269394322 0.1127953077922547 0.0 791 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +554785 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.011717535300353 0.7941469661104034 0.773263018678637 0.6198216015396206 1.0 0.0006800116997025 0.0 0.0119047619047619 1.0 0.0 42 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +555005 CD48 CD2 CD48-CD2 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0117146814753737 0.4593282471594782 0.937587088419394 0.6198216015396206 0.0351142257737683 0.0275738893167071 0.0 0.0007088846880907 0.0295664022398003 0.0 4232 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +555283 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0117110497381351 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0085570823799139 0.0855781119790033 0.0 0.0052770448548812 0.2659099919659342 0.0 379 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +556218 CD34 SELP CD34-SELP T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0116984655497544 0.633566764858408 0.7760344326192508 1.0 0.015517736049123 0.0335947364052305 0.0 0.0007071468979822 0.0594814676076027 0.0 21212 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +556802 COL4A2 CD93 COL4A2-CD93 Pericytes B Cells Pericytes -> B Cells 0.0116899782995827 0.8840293712888387 0.7779918296243433 0.6198216015396206 0.5544396796022323 0.001079730675535 0.0 0.0037629350893697 0.6363700518778473 0.0 1063 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +557195 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0116841754573285 0.6249837837987587 0.7746834992804791 0.8693461273411047 0.00263399584678 0.2295016807597237 0.0 0.0006944444444444 0.0476972640041543 0.0 360 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +557933 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0116744177394869 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.1027229557481577 0.0080072638027924 0.0 0.0016033882922402 0.3872998145212944 0.0 3005 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +558496 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0116667022953056 0.8533682807143209 0.7779918296243433 1.0 0.0706049302656684 0.0053794918117879 0.0 0.0003429855800105 0.0279142304630148 0.0 19576 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +558669 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0116644513869648 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.000716220684292 1.0 0.0 0.0095419847328244 0.0602773370567745 0.0 262 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +558714 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0116638156315987 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.1928969878996252 0.0058437228618857 0.0 0.000951341235184 0.2886940592328713 0.0 6412 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +558844 MMP2 PECAM1 MMP2-PECAM1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0116621991372589 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0216588811659259 0.0326412663903893 0.0 0.0004279083260806 0.1733779265114836 0.0 6894 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +559176 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0116578114601725 0.6301823358791634 0.6587114738285964 1.0 0.0208904415011529 0.0289462771086338 0.0 8.14224622152574e-05 0.0168376150953554 0.0 423716 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +559231 THBS2 CD36 THBS2-CD36 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0116571447762398 0.7809827257946271 0.8587566561291643 0.7827641335561659 0.0004779710276932 1.0 0.0 0.0036231884057971 0.0520232292625583 0.0 460 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +559248 COL4A2 CD93 COL4A2-CD93 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0116568527082926 0.9188764516910942 0.7779918296243433 0.6198216015396206 0.0090193130488293 0.0627790816848129 0.0 0.0011855364552459 0.0260005094802811 0.0 1687 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +559674 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0116510876133194 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0215813276111062 0.0521374123931907 0.0 0.0 0.0 0.0 800 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +560507 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0116403022635044 0.6626993710110988 0.6207977546603366 0.9161861017439124 0.0039530346951707 0.166956519448744 0.0 0.0010723039215686 0.0113617553170444 0.0 408 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +560525 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Mast Cells Macrophages -> Mast Cells 0.0116401070247341 0.7487535481622718 0.7754239189773715 0.8567148457705164 0.0338862305197021 0.0147571931436988 0.0 0.0162534435261707 0.3254923391574683 0.0 165 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +560891 COL4A2 CD93 COL4A2-CD93 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0116351269031586 0.8840293712888387 0.8817184225858201 0.9429656149619918 1.0 0.0003375370073613 0.0 0.0010522213561964 0.8174685905524773 0.0 2566 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +561624 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0116251906518751 0.662063103571249 0.7841656220878274 0.6198216015396206 0.585843718590581 0.001309307002134 0.0 0.0001653439153439 0.0204214963815338 0.0 756 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +561650 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0116247813647032 0.4630253981438691 0.7779918296243433 0.2461374514707439 0.0443339118517084 0.0627790816848129 0.0 0.002200825309491 0.0482672456596801 0.0 727 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +561711 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0116239205378167 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.000716220684292 1.0 0.0 0.0133587786259541 0.0796491410005934 0.0 262 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +562294 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0116158551815438 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0338862305197021 0.0292373734098458 0.0 0.0008264462809917 0.1262030567174446 0.0 715 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +562487 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Macrophages Pericytes -> Macrophages 0.0116136548382781 0.9356727248601746 0.8923034233058523 0.8875000050982297 0.1750253929104546 0.00189193058407 0.0 0.0011764705882352 0.4439349639571183 0.0 2125 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +563026 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0116063172411817 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.1496557267835524 0.0050968401714881 0.0 0.0 0.0 0.0 4836 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +563332 HSPG2 LRP1 HSPG2-LRP1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0116020121632245 0.8818165186409654 0.7346293219749174 0.7204611100467462 0.1619074107723045 0.0032275631628407 0.0 0.0040891144952058 0.2248384382358451 0.0 394 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +563364 CD48 CD2 CD48-CD2 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0116014355999338 0.9011089648206808 0.7464347811605867 0.6198216015396206 0.4567172527116189 0.0012805120781881 0.0 0.0031055900621118 0.7538536679308235 0.0 161 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +564280 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0115885980025898 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0083898580598364 0.12709315903692 0.0 0.0028074721952272 0.1322570476645093 0.0 1323 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +564375 VEGFC FLT1 VEGFC-FLT1 Macrophages Pericytes Macrophages -> Pericytes 0.0115874365347125 0.8963332422588541 0.878254460598671 0.8875000050982297 0.0026007495851186 0.1332188634280341 0.0 0.0010105092966855 0.0380862540540037 0.0 2474 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +564380 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0115873935404234 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.1661175896787547 0.0042655619249233 0.0 0.0022542831379621 0.5708707440735066 0.0 1109 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +564530 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.0115856280256124 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0411127335336962 0.0125623889131764 0.0 0.0006634629178023 0.2137199895779609 0.0 13942 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +564880 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0115806145452283 0.9468422434493456 0.6347970925105053 0.6198216015396206 0.1120119983652299 0.0057802287131517 0.0 0.001753507014028 0.3016724816841708 0.0 1996 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +564930 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0115799146868202 0.2534163760166434 0.8818326005152037 0.2461374514707439 0.0050543892975134 0.8672894033034337 0.0 0.074074074074074 1.0 0.0 9 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +565025 VWF SELP VWF-SELP CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0115786935043339 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0071496754272206 0.0741032966028748 0.0 0.0004396666686078 0.010140666792075 0.0 15611 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +565130 VWF ITGA9 VWF-ITGA9 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0115772780221383 0.955713094717548 0.2531744428854943 0.2461374514707439 1.0 0.0040430820937484 0.0 0.0 0.0 0.0 33 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +565468 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0115730330774592 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0149256517769723 0.049767778498468 0.0 0.0003110957483581 0.1063155637414915 0.0 3945 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +565857 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0115678663132026 0.9097736029185508 0.8445107771175474 0.8693461273411047 0.0430965463818576 0.0083242517891534 0.0 0.001863354037267 0.2179867673143674 0.0 575 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +565944 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0115663983861483 0.7766289238087107 0.4630027772793905 0.7204611100467462 1.0 0.0009242223287825 0.0 0.0052742616033755 1.0 0.0 474 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +565971 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0115658573700728 0.4601010570874773 0.7346293219749174 1.0 0.0170183763647696 0.0416128058995347 0.0 0.000858078797907 0.0339961096645753 0.0 22361 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +566435 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.011559648524179 0.9184503888425788 0.7746834992804791 0.6198216015396206 0.1169448695751571 0.0046263543438723 0.0 0.0013048278630934 0.7113009871883661 0.0 3321 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +566751 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0115550732978165 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0151307911035231 0.0554888093272979 0.0 0.0008832188420019 0.1445451344938056 0.0 5095 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +566886 C3 LRP1 C3-LRP1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0115533266418652 0.9487258305485792 0.6207977546603366 0.6198216015396206 0.0110943464444434 0.0587195251380622 0.0 0.0007619321449108 0.183886679752007 0.0 1739 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +566920 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0115529564401539 0.4629984640915818 0.6207977546603366 0.2461374514707439 0.0201301851612071 0.166956519448744 0.0 0.0065192743764172 0.0365722980402519 0.0 147 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +567441 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0115459310926607 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.0673400749834054 0.0090444648829713 0.0 0.0007440476190476 0.0845021584934511 0.0 3360 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +567597 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0115438821601501 0.7745997874735252 0.777821334064334 1.0 0.0215813276111062 0.0182001711419816 0.0 0.0005959678517913 0.0713805413293505 0.0 19576 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +568188 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0115361662268187 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0342558468646473 0.0265498740402422 0.0 0.008841732979664 0.2246241338094461 0.0 377 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +568670 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0115294552374549 0.6593525851613742 0.8331580262014722 0.6198216015396206 0.4518617096918393 0.001526625481682 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +568779 VWF ITGA9 VWF-ITGA9 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0115279724844288 0.6332974881236617 0.6252253442669611 0.8693461273411047 0.0036144684673052 0.1886404570313 0.0 0.0001233501911927 0.0032260061513344 0.0 737 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +568923 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0115261038745115 0.6593525851613742 0.777821334064334 0.7917001487310438 0.018132161410931 0.0318483483218543 0.0 0.0018840579710144 0.2384303049517158 0.0 2300 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +569286 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0115213830324027 0.6160088550075702 0.8628183098412396 0.8693461273411047 0.0149256517769723 0.0339152418223636 0.0 0.0011317999269806 0.0864721266320094 0.0 1245 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +569661 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0115164398273588 0.6593525851613742 0.777821334064334 0.7917001487310438 0.4518617096918393 0.001271575589586 0.0 0.0005847953216374 0.1432160240257323 0.0 570 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +569816 A2M LRP1 A2M-LRP1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.011514176887521 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.3743986430148447 0.0018097844702233 0.0 0.0054155614500442 0.7307297977444314 0.0 377 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +569898 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0115132641704392 0.6213271600240247 0.8818704453527788 0.6198216015396206 0.1339639999453202 0.0051192928876727 0.0 0.0006415001233654 0.1208552358082532 0.0 1351 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +570072 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0115110538088397 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0526353932596327 0.0083242517891534 0.0 0.0088927137119908 1.0 0.0 83 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +570164 VWF ITGA9 VWF-ITGA9 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0115099088836428 0.7848266128497919 0.9404022517663844 0.7827641335561659 0.0004024409845247 1.0 0.0 0.0009881422924901 0.0110335891306953 0.0 460 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +570264 C3 LRP1 C3-LRP1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.011508472430669 0.6319926036888139 0.6207977546603366 0.8693461273411047 0.0334108479684367 0.0203874717835032 0.0 0.0008480325644504 0.1084730614226021 0.0 737 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +570588 C3 LRP1 C3-LRP1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0115042451360787 0.9487258305485792 0.7346293219749174 0.7204611100467462 0.0110943464444434 0.0416128058995347 0.0 0.002027972027972 0.1894138770250809 0.0 715 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +570711 C3 LRP1 C3-LRP1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0115025753106984 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.005043231651446 0.166956519448744 0.0 0.0015044814340588 0.0211598361739645 0.0 1562 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +570766 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0115018991419895 0.7797302331085993 0.7763400818577846 0.8693461273411047 0.0200499113739789 0.0219439768073448 0.0 0.0018518518518518 0.2542527831537695 0.0 360 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +570856 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0115006236424068 0.4648000335061383 0.2550748532138862 0.2461374514707439 0.2966815529783992 0.0267255153180908 0.0 0.0026947148817802 0.2344062757332015 0.0 5752 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +570876 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0115003500965255 0.4604235282221027 0.4630027772793905 0.8293805866303694 0.0839650520556947 0.0155837683010033 0.0 0.000367216498938 0.0865282017699474 0.0 7197 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +571064 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0114979092499903 0.7324582304061453 0.62431395375366 0.6198216015396206 0.2376713873232418 0.0034299077593249 0.0 0.0016587677725118 0.1715966661219153 0.0 422 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +571102 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0114972219221984 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.0142750905665976 0.0501711964086628 0.0 0.0083732057416267 0.2250546027041362 0.0 209 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +571106 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0114971493077872 0.4630253981438691 0.944024288971064 0.2461374514707439 0.0443339118517084 0.0484215930647349 0.0 0.0004504504504504 0.0166916539567916 0.0 222 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +571367 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0114937340876503 0.6593525851613742 0.6593689120110077 1.0 0.0201572483258557 0.026308073552735 0.0 0.0024699312714776 0.1800182706717872 0.0 1552 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +571481 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0114920217874929 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0149256517769723 0.0521257226458961 0.0 0.0067639035795802 0.2828823759043182 0.0 1633 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +571500 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0114917260487769 0.7800321422220979 0.9015117569158254 0.6198216015396206 0.0213929720256037 0.0246995741084876 0.0 0.000581226387678 0.0560030363083806 0.0 3441 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +571541 COL4A1 CD93 COL4A1-CD93 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0114911509695533 0.7766289238087107 0.6587114738285964 0.6198216015396206 1.0 0.0007261054236978 0.0 0.0086996336996337 1.0 0.0 312 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +571894 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0114865028015154 0.7160288858520609 0.4638256179742202 0.8293805866303694 0.0186793449598515 0.0446401662952339 0.0 0.0005384485949856 0.0487287230207638 0.0 9905 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +571956 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0114856530334879 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0215813276111062 0.026308073552735 0.0 0.0010416666666666 0.0759207489354928 0.0 1280 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +572066 A2M LRP1 A2M-LRP1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.011484298172273 0.8392912392980421 0.7346293219749174 0.7204611100467462 0.0005164482812395 1.0 0.0 0.0059638168427793 0.0706151767136518 0.0 1041 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +572233 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0114822671184364 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0323110954490285 0.0312252462757311 0.0 0.0103016924208977 0.5610706952135258 0.0 453 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +572398 COL4A1 CD93 COL4A1-CD93 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0114801547337139 0.7766289238087107 0.7461459456652184 0.7827641335561659 0.4857192596400828 0.0010390313650636 0.0 0.0031645569620253 0.3010982312805511 0.0 316 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +572474 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.011479178848591 0.4619393085577573 0.9015117569158254 0.7204611100467462 0.0308750930304183 0.0246995741084876 0.0 0.0005287648054145 0.050948193722805 0.0 591 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +573117 VEGFC FLT1 VEGFC-FLT1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0114700962174453 0.8963332422588541 0.6593689120110077 0.6198216015396206 0.0026007495851186 0.2390217618875283 0.0 0.0002875215641173 0.0284690384710832 0.0 1739 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +573211 CD34 SELP CD34-SELP Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.01146872072376 0.9303167350027568 0.6572093097629401 0.6198216015396206 0.1314667522621683 0.0045674276780054 0.0 0.0 0.0 0.0 398 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +573489 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0114651278430161 0.7487535481622718 0.7757991160529997 0.8567148457705164 0.1027229557481577 0.0044430418127202 0.0 0.009090909090909 0.3398283077028637 0.0 225 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +573511 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.011464850101882 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0236359933700329 0.0326667674102811 0.0 0.05 1.0 0.0 5 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +573669 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0114626939964394 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.0699064461360958 0.0144613249009303 0.0 0.010548523206751 0.0611311711917318 0.0 79 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +573936 COL4A2 CD93 COL4A2-CD93 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0114593053069587 0.7783550150988336 0.7779918296243433 1.0 0.0316800311254893 0.0118035014556376 0.0 0.0005421459551197 0.0548641105738575 0.0 21212 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +574267 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0114545061767977 0.8721681415062816 0.7467524951532132 0.7827641335561659 0.0425206505665654 0.0104195741475089 0.0 0.0004230118443316 0.0291878172588832 0.0 394 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +574347 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0114533980527265 0.6332974881236617 0.6572093097629401 1.0 0.0131302879503246 0.04130664769978 0.0 3.840479772471952e-05 0.0130351447524464 0.0 423716 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +574998 VEGFC FLT1 VEGFC-FLT1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0114449036731422 0.8718210606749883 0.4630488285702799 0.7204611100467462 0.1796394187986057 0.0043013567716651 0.0 0.0025380710659898 0.2012970142691556 0.0 394 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +575251 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0114420701178836 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0048313935743179 0.1281708518900828 0.0 0.0037693177534866 0.0888161118891109 0.0 379 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +575392 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0114401319521499 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0342558468646473 0.0312252462757311 0.0 0.0034574526099949 0.1883064704613512 0.0 2183 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +575646 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0114369970214306 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.454846709299195 0.0026174949623928 0.0 0.0 0.0 0.0 233 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +576239 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0114290823862312 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0073929685753755 0.0855781119790033 0.0 0.00084388185654 0.0425231590527801 0.0 3555 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +576311 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0114280317319768 0.6659645551150886 0.6614977577544194 0.8824495942126559 0.1496557267835524 0.0038288178384739 0.0 0.0006277726625931 0.1174120159708693 0.0 11947 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +576477 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0114256358451413 0.8640667164982425 0.7167436199046466 0.7204611100467462 0.1882781599600688 0.0026482500471321 0.0 0.0007157581310123 0.2670858714638411 0.0 2183 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +576488 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.011425474588077 0.7148920381722296 0.7769451595923457 0.7204611100467462 1.0 0.0005558995075445 0.0 0.0049205147615442 1.0 0.0 1321 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +576545 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0114247005172961 0.4619393085577573 0.7167436199046466 0.2461374514707439 0.0835287751665837 0.0326667674102811 0.0 0.0016084558823529 0.0340491858242423 0.0 272 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +576756 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0114220108247616 0.6342079770588467 0.4641352222874551 0.2461374514707439 0.0673400749834054 0.0455121851821151 0.0 0.0 0.0 0.0 184 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +576881 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0114205822212245 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0255753403203798 0.0293031867940321 0.0 0.0036951796445467 0.4624534037992909 0.0 3555 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +577168 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0114168855384332 0.6626993710110988 0.6207977546603366 0.9161861017439124 0.0035190936623492 0.166956519448744 0.0 0.0032751091703056 0.0347019051979097 0.0 458 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +577306 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0114153433898056 0.8840293712888387 0.944024288971064 0.8875000050982297 0.0061698665784747 0.0484215930647349 0.0 0.0011938202247191 0.0442375716523396 0.0 1424 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +577462 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0114132467265426 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0255753403203798 0.0267210109213584 0.0 0.0018181818181818 0.1910432393331707 0.0 2400 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +577662 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0114103566039482 0.6160088550075702 0.9546923450729716 0.7917001487310438 0.0106340017102282 0.0445745465878424 0.0 0.0004784688995215 0.0177201764575319 0.0 570 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +577705 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0114097418198388 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0071496754272206 0.1112417752963437 0.0 0.0001109323867103 0.0119910751165928 0.0 3278 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +577721 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0114095676045912 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.1357656553382984 0.0041555861088636 0.0 0.000634765625 0.0806147929639913 0.0 1280 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +577832 COL4A1 CD93 COL4A1-CD93 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0114081483819759 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0168149984327668 0.0289462771086338 0.0 0.0004526525439072 0.0668992787739442 0.0 3945 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +577966 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0114062956614685 0.7296454584598743 0.4638256179742202 0.2461374514707439 0.0051524613572059 0.5131068416842878 0.0 0.004920049200492 0.118834974313897 0.0 271 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +578080 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0114047259085826 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.0839650520556947 0.0118035014556376 0.0 0.000914913083257 0.0868110829496905 0.0 1093 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +578560 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0113986038446527 0.6582846571368821 0.6587114738285964 0.8824495942126559 0.0198024073017111 0.0289462771086338 0.0 0.0002974960747045 0.0633364602143469 0.0 12101 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +579025 CD34 SELP CD34-SELP Pericytes Macrophages Pericytes -> Macrophages 0.0113924276873152 0.9303167350027568 0.941479368642921 0.8875000050982297 0.1314667522621683 0.0021392900294222 0.0 0.0009411764705882 0.3044527851190194 0.0 2125 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +579034 A2M LRP1 A2M-LRP1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0113923667371936 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.0149044683666724 0.0416128058995347 0.0 0.0017279603547209 0.1025023954806473 0.0 1278 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +579244 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0113896333171961 0.7487535481622718 0.9008184599638702 0.6198216015396206 0.0016417770622885 0.3180524283074206 0.0 0.0061728395061728 0.0857815682478588 0.0 162 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +579392 VWF SELP VWF-SELP Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0113877047194032 0.9275752708651288 0.6572093097629401 0.6198216015396206 0.1263644540569636 0.0045674276780054 0.0 0.0007994518044769 0.1345541600566366 0.0 398 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +579420 VWF SELP VWF-SELP Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0113873814102443 0.7848266128497919 0.8819126042133903 0.7827641335561659 0.0004024409845247 1.0 0.0 0.0017786561264822 0.0100013368526925 0.0 460 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +579491 COL4A1 CD93 COL4A1-CD93 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0113866403171162 0.7766289238087107 0.8817184225858201 0.9429656149619918 1.0 0.0003375370073613 0.0 0.0012248079278476 1.0 0.0 2566 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +579597 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0113852447300369 0.6561647292424944 0.8604147465201248 0.6198216015396206 0.0142750905665976 0.0436001007095475 0.0 0.0028317152103559 0.0811217086594881 0.0 103 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +579678 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0113841664132614 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0255753403203798 0.0484993884807927 0.0 0.0130689787071273 0.1857948773640566 0.0 713 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +579852 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0113817097421374 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0149256517769723 0.0491709261488903 0.0 0.0058175137783221 0.2625297047013928 0.0 1633 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +579883 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes B Cells Pericytes -> B Cells 0.0113813399679418 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0110717612136884 0.0467761235673353 0.0 0.0012543116964565 0.0705369310614233 0.0 1063 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +580223 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0113769796188645 0.7789175740361626 0.6207977546603366 0.8693461273411047 0.0492631209980634 0.0104714078116759 0.0 0.0007246376811594 0.0605702687507438 0.0 575 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +580246 CD34 SELP CD34-SELP Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0113766803634033 0.9303167350027568 0.4623922682986163 0.7204611100467462 0.1314667522621683 0.0053213839468185 0.0 0.0016032982134677 0.6280151050349788 0.0 2183 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +580392 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0113747854706256 0.6242573126045354 0.6176321640000088 0.9161861017439124 0.1932385901170197 0.0031731220372828 0.0 0.0023764258555133 1.0 0.0 526 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +580432 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0113742342583985 0.7487535481622718 0.9460955677032749 0.6198216015396206 0.0131092554497256 0.0376195773145198 0.0 0.0035628088725433 0.1296285905654683 0.0 791 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +580460 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0113738261313298 0.6213271600240247 0.62431395375366 0.9161861017439124 0.0093830613230477 0.0649213179279442 0.0 0.0009461426491994 0.0389823137931359 0.0 458 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +580491 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.011373396208008 0.6342079770588467 0.6580560501976399 1.0 0.0085570823799139 0.0606066271159369 0.0 0.003221649484536 0.0912189270557539 0.0 1552 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +580652 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0113714102889999 0.6160088550075702 0.6632137581773894 1.0 0.0106340017102282 0.049767778498468 0.0 6.983665731506308e-05 0.0238663615027152 0.0 423716 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +580805 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0113692949073002 0.662063103571249 0.9015117569158254 0.6198216015396206 0.0236359933700329 0.0246995741084876 0.0 0.002626050420168 0.2530284242872083 0.0 119 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +580842 CD34 SELP CD34-SELP Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0113688370365498 0.9303167350027568 0.7760344326192508 0.6198216015396206 0.1314667522621683 0.0036702914086929 0.0 0.000501002004008 0.2049005089584042 0.0 1996 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +580966 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.011367230906827 0.6605327397359113 0.885766439573873 0.6198216015396206 0.0179229861158654 0.0331922776397286 0.0 0.0 0.0 0.0 262 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +581007 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0113666897810628 0.6342079770588467 0.7754072541855492 1.0 0.0053032910137447 0.0826982152707935 0.0 0.0003064977523498 0.0113761627283393 0.0 19576 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +581392 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0113615777937841 0.6303642896310324 0.6331674633943454 0.9161861017439124 0.141548283585814 0.0041555861088636 0.0 0.0043726235741444 0.8307915308562549 0.0 526 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +581640 VWF ITGA9 VWF-ITGA9 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0113583842082307 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.1263644540569636 0.0047273851759697 0.0 0.0016879672052085 0.0791508247233255 0.0 377 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +581697 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0113576169098342 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.0084325366891025 0.0627790816848129 0.0 0.0015544041450777 0.0340903053056225 0.0 193 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +581719 A2M LRP1 A2M-LRP1 Pericytes B Cells Pericytes -> B Cells 0.0113573104484361 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.3743986430148447 0.0016667952436519 0.0 0.0040373157729695 0.8107239324978822 0.0 1063 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +581829 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0113559880808757 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0083565457974945 0.0741032966028748 0.0 0.0 0.0 0.0 379 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +582050 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0113533355499492 0.6303682835571691 0.8891607331132086 0.6198216015396206 0.0101610580570933 0.0606680526002441 0.0 0.0021925761225372 0.0725106375530831 0.0 1542 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +582127 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0113522973239496 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0085570823799139 0.1370986982961073 0.0 0.0042016806722689 0.1353563447033234 0.0 714 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +582213 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0113512469145441 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.0179229861158654 0.0293997450046583 0.0 0.0 0.0 0.0 193 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +582350 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0113495895075784 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0052560850129547 0.1449812920932466 0.0 0.0008658008658008 0.0709677035829823 0.0 77 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +582848 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0113428114060791 0.7296454584598743 0.7470475610360806 0.7204611100467462 0.7029371915698084 0.0007714919761827 0.0 0.0002523340903356 0.0387458603776545 0.0 1321 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +583001 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0113408031556302 0.6319926036888139 0.6207977546603366 1.0 0.0265972645862203 0.0203874717835032 0.0 0.0009450347364119 0.1208807483421717 0.0 19576 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +583205 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Mast Cells Pericytes -> Mast Cells 0.0113383960279783 0.9184503888425788 0.836885603004631 0.8567148457705164 0.1169448695751571 0.0027591088867233 0.0 0.0 0.0 0.0 225 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +583449 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0113353492812071 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0587727051993296 0.0203874717835032 0.0 0.0007295719844357 0.0413159639046335 0.0 1542 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +583662 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0113324001405426 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0255753403203798 0.0279580382843415 0.0 0.0015348535692495 0.2152303556590834 0.0 4768 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +583773 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0113308616051765 0.4601010570874773 0.8604147465201248 0.7204611100467462 0.0170183763647696 0.0436001007095475 0.0 0.0006345177664974 0.0148758142728376 0.0 591 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +583902 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0113294799543347 0.4619393085577573 0.9015117569158254 0.2461374514707439 0.0835287751665837 0.0246995741084876 0.0 0.0008445945945945 0.0813794121356156 0.0 222 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +584025 CD34 SELP CD34-SELP T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0113279395450786 0.633566764858408 0.6572093097629401 0.7917001487310438 0.015517736049123 0.04130664769978 0.0 0.0 0.0 0.0 1165 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +584383 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0113231204987715 0.724503440376099 0.6176321640000088 0.6198216015396206 1.0 0.0007598956708367 0.0 0.0024691358024691 1.0 0.0 135 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +584400 CD34 SELP CD34-SELP Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0113227593943115 0.9559599666576516 0.7760344326192508 0.6198216015396206 1.0 0.0004582650848664 0.0 0.0010578279266572 0.7870867424382662 0.0 1418 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +584444 VWF SELP VWF-SELP Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0113222720007539 0.955713094717548 0.7760344326192508 0.6198216015396206 1.0 0.0004582650848664 0.0 0.0020836004615976 1.0 0.0 1418 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +584664 COL4A1 CD93 COL4A1-CD93 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0113193548734764 0.7766289238087107 0.4630027772793905 0.2461374514707439 0.4857192596400828 0.0048929293424311 0.0 0.002095337873232 0.5638408841025067 0.0 1909 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +584688 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0113190823551566 0.7487535481622718 0.7754239189773715 0.9429656149619918 0.0131092554497256 0.0293031867940321 0.0 0.0009181309678512 0.114904505885924 0.0 3218 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +584909 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0113161058360204 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0291791383241764 0.0218093597373452 0.0 0.0069341591490507 0.3757990723625075 0.0 2122 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +585037 CD48 CD2 CD48-CD2 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0113145176676055 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0212837736082081 0.0229905310518441 0.0 0.0029638411381149 0.1397363825646192 0.0 1687 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +585225 VWF SELP VWF-SELP Pericytes Macrophages Pericytes -> Macrophages 0.0113119506233618 0.9275752708651288 0.941479368642921 0.8875000050982297 0.1263644540569636 0.0021392900294222 0.0 0.0014973262032085 0.2681990349577695 0.0 2125 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +585571 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0113073708743516 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0007263013575398 1.0 0.0 0.001592356687898 0.0282089316261469 0.0 157 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +585697 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0113057889783851 0.6626993710110988 0.8604147465201248 0.6198216015396206 0.0135527119637784 0.0436001007095475 0.0 0.002939015429831 0.068903110342372 0.0 1361 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +585728 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0113053895904324 0.718867305289982 0.6331674633943454 0.6198216015396206 1.0 0.0007400708115376 0.0 0.005 1.0 0.0 135 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +586290 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0112980476383495 0.4601010570874773 0.6207977546603366 0.2461374514707439 0.0177188549930425 0.166956519448744 0.0 0.0 0.0 0.0 147 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +586421 VWF SELP VWF-SELP Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0112963145398658 0.9275752708651288 0.4623922682986163 0.7204611100467462 0.1263644540569636 0.0053213839468185 0.0 0.0014783658851455 0.6754948148637453 0.0 2183 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +586444 VWF ITGA9 VWF-ITGA9 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0112960241737508 0.9275752708651288 0.950463483645931 0.9429656149619918 0.1263644540569636 0.0019776346124415 0.0 0.0006130080304051 0.2571849156536713 0.0 2966 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +586564 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0112945477255917 0.8978557803479422 0.4642836810638544 0.7204611100467462 0.0477973731763516 0.0144613249009303 0.0 0.004601226993865 0.0266651918511174 0.0 326 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +586663 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0112933852295617 0.2534163760166434 0.6580560501976399 0.2461374514707439 0.0050543892975134 1.0 0.0 0.0013586956521739 0.0742553448570556 0.0 184 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +587025 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0112890193063903 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0548063857429699 0.0215025911544899 0.0 0.0010796804145972 0.1297081341205321 0.0 1684 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +587063 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0112885504820265 0.8667347161816407 0.937587088419394 0.8693461273411047 0.0106228227237899 0.0275738893167071 0.0 0.0 0.0 0.0 270 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +587066 VWF SELP VWF-SELP Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0112885266189305 0.9275752708651288 0.7760344326192508 0.6198216015396206 0.1263644540569636 0.0036702914086929 0.0 0.000432683548916 0.1804722502822816 0.0 1996 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +587214 MMRN2 CD93 MMRN2-CD93 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0112868075649207 0.9468422434493456 0.4630027772793905 0.7204611100467462 0.1120119983652299 0.0058437228618857 0.0 0.0019468621163536 0.3939806238109459 0.0 2183 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +587320 THBS2 CD36 THBS2-CD36 Macrophages Macrophages Macrophages -> Macrophages 0.0112854857999376 0.8858959974474152 0.8587566561291643 1.0 0.0030563796158022 0.088850508457521 0.0 0.0014917276918904 0.029133896765676 0.0 2458 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +587736 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0112796705715086 0.4593282471594782 0.8960994285623033 0.6198216015396206 0.0351142257737683 0.0229905310518441 0.0 0.0017827756445419 0.0840526222168037 0.0 3646 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +588066 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0112755192841766 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.1882781599600688 0.0032187363284526 0.0 0.0017148585901224 0.3377930080885453 0.0 2369 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +588374 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.011271316085071 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0131302879503246 0.0501711964086628 0.0 0.0007169913419913 0.0145353018069363 0.0 3360 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +588382 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0112711227010116 0.6213271600240247 0.62431395375366 0.8824495942126559 0.0093830613230477 0.0638329144736252 0.0 0.0003966614329394 0.1035517806628487 0.0 12101 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +588425 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0112704462931987 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.1928969878996252 0.0026174949623928 0.0 0.00328125 0.4451528945761718 0.0 1280 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +588630 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0112676501400242 0.7840818683779507 0.6580560501976399 0.6198216015396206 0.0032417203409647 0.1973932010691654 0.0 0.0041666666666666 0.0745738579521843 0.0 160 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +588704 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0112665760936651 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.1496557267835524 0.0071918009517169 0.0 0.0005810575246949 0.142017867899598 0.0 5163 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +589276 CD48 CD2 CD48-CD2 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0112590144416982 0.7719609236370527 0.937587088419394 0.6198216015396206 0.0164675938709007 0.0275738893167071 0.0 0.0038787023977433 0.161774230966994 0.0 1418 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +589375 CCN1 CAV1 CCN1-CAV1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0112575995171834 0.9219165193585238 0.7832252605020791 0.7827641335561659 0.2646489893253856 0.00136079311934 0.0 0.0012658227848101 0.1860771295602994 0.0 316 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +589636 C3 LRP1 C3-LRP1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0112543143464249 0.9487258305485792 0.6207977546603366 0.6198216015396206 0.0110943464444434 0.0501711964086628 0.0 0.0037048014226437 0.1065984781867182 0.0 1687 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +589711 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0112532623099243 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.1027229557481577 0.0064230792457803 0.0 0.0014518650882287 0.1952754218394223 0.0 407 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +589899 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0112506402510602 0.4625081978296446 0.4642836810638544 0.8767341187813953 0.0141498126994191 0.0761275033764692 0.0 0.0016326530612244 0.1572403086158957 0.0 2450 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +589901 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0112506076971085 0.6249837837987587 0.6580560501976399 0.9592803095773328 0.0084812136822336 0.0606066271159369 0.0 0.0023712737127371 0.0568543534318418 0.0 1476 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +589954 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0112499803832381 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0078992851324392 0.0741032966028748 0.0 0.0002773155851358 0.0139426047368507 0.0 1803 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +590097 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0112479918413933 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.0227314494836465 0.0219439768073448 0.0 0.0002323420074349 0.0318997450982889 0.0 2152 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +590799 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.011239216527049 0.9275752708651288 0.9404022517663844 0.9429656149619918 0.000245041593909 1.0 0.0 0.0007715531700771 0.0086151566791702 0.0 2710 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +591262 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0112323806346761 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0106340017102282 0.1076178292491983 0.0 0.0002305874214561 0.0193187823203981 0.0 1577 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +591275 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0112321865536787 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0131092554497256 0.049767778498468 0.0 0.0001439700542287 0.0492011143128845 0.0 5683 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +591300 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0112318458560528 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0291791383241764 0.0265498740402422 0.0 0.0081654456654456 0.2074430616698546 0.0 312 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +591311 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0112316839884049 0.7487535481622718 0.7757991160529997 0.9429656149619918 0.0131092554497256 0.0279580382843415 0.0 0.0009225092250922 0.1293621701726707 0.0 2710 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +591338 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0112313070058708 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0131302879503246 0.0487643047611538 0.0 0.0003246753246753 0.0127087182270229 0.0 3360 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +591495 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0112291514771644 0.6213271600240247 0.8818704453527788 0.6198216015396206 0.1153131738111426 0.0051192928876727 0.0 0.0009122807017543 0.1718688669231053 0.0 475 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +591498 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0112291318355574 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0415873844357376 0.0118035014556376 0.0 0.00034548281223 0.0327809686177273 0.0 827 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +591618 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0112274687743754 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0161757332769496 0.0689186266365139 0.0 0.0007743804956035 0.0943565516840135 0.0 3336 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +591666 VWF LRP1 VWF-LRP1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0112267703567922 0.9275752708651288 0.7346293219749174 0.7204611100467462 0.1263644540569636 0.0032275631628407 0.0 0.0036628980156898 0.1743565378314414 0.0 394 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +591742 CD34 SELP CD34-SELP Macrophages Pericytes Macrophages -> Pericytes 0.0112256879647756 0.8963354148873306 0.8819126042133903 0.8875000050982297 0.0038492365148421 0.0741032966028748 0.0 0.0004042037186742 0.0203221635735989 0.0 2474 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +592112 CD48 CD2 CD48-CD2 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0112208649050002 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0467114894617178 0.0226890201466244 0.0 0.0033783783783783 0.4896624481441167 0.0 148 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +592144 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0112204452186736 0.7158082793127664 0.863034163938375 0.7204611100467462 0.0071496754272206 0.0627102121186242 0.0 0.0021004873130566 0.016872889876392 0.0 1082 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +592195 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0112198656165269 0.9219165193585238 0.62431395375366 0.6198216015396206 0.0086134406931133 0.0649213179279442 0.0 0.0007501172058134 0.0309058093125716 0.0 1422 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +592216 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0112196666213033 0.8023917560710954 0.7754239189773715 0.7204611100467462 0.0085367158000785 0.0521257226458961 0.0 0.0014613136440547 0.0611155778180476 0.0 591 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +592506 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0112158286872497 0.4630253981438691 0.7461459456652184 0.7204611100467462 0.7696906278989153 0.0010390313650636 0.0 0.003557910673732 0.5217426920018365 0.0 1321 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +592645 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0112141245507598 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.0201572483258557 0.0521374123931907 0.0 0.0031847133757961 0.5665867436095426 0.0 157 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +592768 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0112126611276352 0.4630253981438691 0.4630027772793905 0.2461374514707439 0.7696906278989153 0.0048929293424311 0.0 0.0010431154381084 0.3372842008773958 0.0 5752 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +593180 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0112076147054623 0.6589792304505506 0.6207977546603366 0.9161861017439124 0.1836996873148393 0.0028784826949613 0.0 0.0061523024926066 0.4549050818871359 0.0 526 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +593323 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0112058221156938 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0028649117803088 0.1993723722552783 0.0 0.0036968576709796 0.1369657130601569 0.0 2164 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +593503 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0112035217032702 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0186793449598515 0.0362497659817488 0.0 0.0 0.0 0.0 135 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +593725 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0112005051278467 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0106922602624424 0.0518891167572028 0.0 0.0029875986471251 0.1090795020417588 0.0 887 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +593905 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0111982339080353 0.9219165193585238 0.62431395375366 0.6198216015396206 0.0086134406931133 0.0641739251983978 0.0 0.0003503503503503 0.0332815925616963 0.0 1332 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +593933 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.011197837822789 0.7797302331085993 0.657421674383923 0.7917001487310438 0.0699064461360958 0.0069492509109592 0.0 0.0004463488662738 0.0763821299865849 0.0 1867 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +594004 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.011196981591711 0.718867305289982 0.930308383061206 0.7204611100467462 1.0 0.0004089864655001 0.0 0.0005773420479302 1.0 0.0 11475 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +594040 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0111966054923652 0.6342079770588467 0.4638256179742202 0.2461374514707439 0.0053032910137447 0.5131068416842878 0.0 0.0022805017103762 0.0518066402934592 0.0 877 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +594441 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.011191679303805 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0069047442087267 0.0826982152707935 0.0 0.0005818181818181 0.0215951283946637 0.0 6875 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +594509 COL4A1 CD93 COL4A1-CD93 Pericytes B Cells Pericytes -> B Cells 0.0111907712839427 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.4857192596400828 0.001079730675535 0.0 0.0031581776642924 0.4861232123571529 0.0 1063 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +594625 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0111895878467912 0.4619393085577573 0.6331674633943454 0.2461374514707439 0.0835287751665837 0.0326412663903893 0.0 0.0 0.0 0.0 186 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +594709 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.011188294253537 0.9219165193585238 0.62431395375366 0.6198216015396206 0.0086134406931133 0.0638329144736252 0.0 0.0001759633996128 0.0459367154159016 0.0 5683 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +594744 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0111877912011685 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0244483651952677 0.0446401662952339 0.0 0.005485527544351 0.6190321506368442 0.0 714 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +594758 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0111876646093411 0.4625081978296446 0.657421674383923 0.6198216015396206 0.149715856631667 0.0069492509109592 0.0 0.0005977286312014 0.1022872229658965 0.0 1673 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +594770 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0111875176126393 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.002196330917593 0.2295016807597237 0.0 0.0008519206939281 0.0423495180360476 0.0 2152 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +594923 C1QB LRP1 C1QB-LRP1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0111856486806101 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0111808254589153 0.0587195251380622 0.0 0.0002447780678851 0.0208613006878805 0.0 6894 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +594948 CD34 SELP CD34-SELP Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0111853267805791 0.9303167350027568 0.7478729882108823 0.7827641335561659 0.1314667522621683 0.0027351735586246 0.0 0.0 0.0 0.0 316 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +595027 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0111842858066374 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0020491452254277 0.287457858136305 0.0 0.0014327971898687 0.0435764053317261 0.0 1803 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +595266 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0111812679042931 0.8498991475190484 0.6207977546603366 1.0 0.018166235813628 0.0203874717835032 0.0 0.0004437832039231 0.025131626797528 0.0 19576 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +595566 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.01117730005708 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.016822895653248 0.0521374123931907 0.0 0.0003983209241045 0.0708645735641803 0.0 10879 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +595985 THBS2 CD36 THBS2-CD36 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0111724707435014 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0087456089304998 0.0455125113141721 0.0 0.0004751997123115 0.1080543736938672 0.0 12977 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +596366 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0111674173837562 0.718867305289982 0.7167436199046466 0.8293805866303694 0.0361307801045652 0.0125623889131764 0.0 0.0004272613588995 0.1376328513936357 0.0 7197 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +597183 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0111573402005544 0.7296454584598743 0.4638256179742202 0.8767341187813953 0.7029371915698084 0.0009249287638231 0.0 0.0009512161978529 0.5476320157413528 0.0 2453 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +597767 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.011149863139628 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.1740454925211078 0.0058437228618857 0.0 0.0002517915940344 0.0764086898309066 0.0 5163 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +597880 A2M LRP1 A2M-LRP1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.011148289083461 0.4648000335061383 0.7346293219749174 0.8293805866303694 0.2100317344087863 0.0032275631628407 0.0 0.007800608828006 0.4606731744989882 0.0 219 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +598143 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0111446277080098 0.9067635403815892 0.9015117569158254 0.8875000050982297 0.0106922602624424 0.0246995741084876 0.0 0.0027738764044943 0.1411877039737778 0.0 1424 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +598588 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0111392612292074 0.8624864526942296 0.7746834992804791 0.6198216015396206 0.0020100505037262 0.2295016807597237 0.0 0.0 0.0 0.0 30 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +598629 CD48 CD2 CD48-CD2 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0111386891019698 0.9426443637490616 0.4603649459881741 0.6198216015396206 0.0632786830726401 0.0112209532878862 0.0 0.0012233912405187 0.2403744718057179 0.0 4087 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +598659 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0111383449347961 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0291791383241764 0.0312252462757311 0.0 0.0039741285115082 0.2164466726162947 0.0 2702 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +598679 C1QB LRP1 C1QB-LRP1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0111381291654557 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0111808254589153 0.0416128058995347 0.0 0.0013742556115437 0.0544464501292328 0.0 2183 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +598681 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.011138079812865 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.0161757332769496 0.0362497659817488 0.0 0.0003987240829346 0.0135986902324581 0.0 209 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +599064 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.011132996154835 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0561415215593491 0.0104714078116759 0.0 0.0003862689775628 0.0322870537778551 0.0 827 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +599193 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.011131035392213 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.4344545964241579 0.001079730675535 0.0 0.0027262813522355 0.4610560013264392 0.0 917 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +599239 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0111305100018273 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.1671376945154473 0.0032275631628407 0.0 0.0015822784810126 0.0934431230768247 0.0 79 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +599332 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0111291369761991 0.6593525851613742 0.6593689120110077 0.9161861017439124 0.018132161410931 0.026308073552735 0.0 0.0012674271229404 0.0923750557390027 0.0 526 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +599709 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0111243965668993 0.7941469661104034 0.7426180951053148 0.6198216015396206 1.0 0.0005184623914895 0.0 0.0017321743512219 0.203760402250417 0.0 756 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +599788 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0111233342055982 0.7205550478301406 0.7154802332407408 0.8293805866303694 0.0151307911035231 0.0292771742399634 0.0 0.0011810476587467 0.1352998698954588 0.0 7197 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +599918 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0111216984549903 0.718867305289982 0.930308383061206 0.7204611100467462 0.0024319941937022 0.1615013370958009 0.0 0.0031526548672566 0.0973700680977391 0.0 452 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +600078 VWF SELP VWF-SELP CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0111195706794615 0.9275752708651288 0.8819126042133903 0.9429656149619918 0.000245041593909 1.0 0.0 0.0017443810801744 0.0098086091642642 0.0 2710 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +600313 CD34 SELP CD34-SELP Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0111165206424031 0.9303167350027568 0.7760344326192508 0.6198216015396206 0.1314667522621683 0.0032078747392388 0.0 0.0018999366687777 0.4349614075440778 0.0 1579 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +600390 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0111155466964561 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0149256517769723 0.0390724515618796 0.0 0.0003802281368821 0.2148361730613778 0.0 3945 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +600580 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0111132170837072 0.4636527906642655 0.777821334064334 0.2461374514707439 0.0666348171285698 0.0318483483218543 0.0 0.0015822784810126 0.2002396670115432 0.0 316 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +600673 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0111119689162267 0.8023917560710954 0.7757991160529997 0.7204611100467462 0.0085367158000785 0.0491709261488903 0.0 0.001153668666359 0.05206215332589 0.0 591 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +600995 VWF LRP1 VWF-LRP1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0111077973995042 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0036144684673052 0.166956519448744 0.0 0.0025189393939393 0.0189796098784273 0.0 2400 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +601119 VWF SELP VWF-SELP Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0111063126947875 0.9275752708651288 0.7478729882108823 0.7827641335561659 0.1263644540569636 0.0027351735586246 0.0 0.0083429228998849 0.4579305833985939 0.0 316 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +601202 CCN1 CAV1 CCN1-CAV1 Pericytes Mast Cells Pericytes -> Mast Cells 0.0111054898186264 0.9219165193585238 0.8617632615906476 0.8567148457705164 0.2646489893253856 0.0010414441948928 0.0 0.0066666666666666 0.84251458198315 0.0 225 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +601253 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0111048262195976 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0272543760657653 0.0265498740402422 0.0 0.018562401263823 0.4715776098305184 0.0 422 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +601303 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.011104328632117 0.6303642896310324 0.6331674633943454 0.8693461273411047 0.0104129581710415 0.0518891167572028 0.0 0.0035440613026819 0.1293963774130153 0.0 1044 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +601401 C1QB LRP1 C1QB-LRP1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0111029716850965 0.8703788833238396 0.7769451595923457 0.6198216015396206 0.8040181448318822 0.0005558995075445 0.0 0.0031055900621118 0.3918041564607824 0.0 161 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +601481 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0111020524249732 0.6659645551150886 0.937587088419394 0.7917001487310438 0.0137371823984124 0.0275738893167071 0.0 0.0 0.0 0.0 42 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +601556 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0111010960500274 0.7148920381722296 0.8755243548400705 0.7204611100467462 1.0 0.0004150165744076 0.0 0.0036968576709796 1.0 0.0 1082 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +601571 THBS2 CD36 THBS2-CD36 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0111009626230861 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0063387366560491 0.088850508457521 0.0 0.0011503438922793 0.0224665670449691 0.0 3441 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +601703 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0110993517565779 0.7800321422220979 0.6331674633943454 1.0 0.0213929720256037 0.0176963220730796 0.0 0.0003771450122572 0.0689438048269045 0.0 21212 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +601720 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0110991328183576 0.8949858186325867 0.7746834992804791 0.6198216015396206 0.001895566065636 0.2295016807597237 0.0 0.0002805836139169 0.0139479894113214 0.0 594 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +601788 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0110981362480666 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0028649117803088 0.1973932010691654 0.0 0.0022608449908153 0.0404639839672725 0.0 2359 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +602967 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0110835701719308 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0117842887908422 0.0554888093272979 0.0 0.0005084401057555 0.0832098908826452 0.0 3278 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +603016 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0110829082989822 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.011891719340537 0.0501711964086628 0.0 0.0022470238095238 0.0646537536615477 0.0 3360 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +603221 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0110802036525658 0.4625081978296446 0.657421674383923 0.2461374514707439 0.3558005706994493 0.0069492509109592 0.0 0.0 0.0 0.0 147 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +603234 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0110800316269834 0.9468422434493456 0.6347970925105053 0.6198216015396206 0.1120119983652299 0.0044340558155446 0.0 0.0008375209380234 0.1092172964129983 0.0 398 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +603243 C3 LRP1 C3-LRP1 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0110799954203318 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0091898156146168 0.0587195251380622 0.0 5.8021467943138976e-05 0.0140030515389916 0.0 6894 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +603322 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0110789676664009 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0073929685753755 0.1370986982961073 0.0 0.001564945226917 0.0504144132071846 0.0 1278 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +603326 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0110789338464385 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0093830613230477 0.0641739251983978 0.0 0.0022988505747126 0.2183797107989144 0.0 1305 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +603619 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0110755587377086 0.6160088550075702 0.9460955677032749 0.7917001487310438 0.0106340017102282 0.0376195773145198 0.0 0.0007177033492822 0.0261127882353019 0.0 570 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +603649 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0110751537988549 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.0142750905665976 0.0350138403862125 0.0 0.0012093227792436 0.070613361765171 0.0 379 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +604362 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0110655933418377 0.4636527906642655 0.4630488285702799 0.2461374514707439 0.0666348171285698 0.0521374123931907 0.0 0.0008881601421056 0.1580110054938958 0.0 4879 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +604805 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0110601042289104 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.1671376945154473 0.0028784826949613 0.0 0.00439453125 0.7103510547316118 0.0 1280 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +605088 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0110566687386977 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0308750930304183 0.0326412663903893 0.0 0.0002576054955839 0.0877501068919968 0.0 5095 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +605194 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0110551762831924 0.4625081978296446 0.7467524951532132 0.7204611100467462 0.0704104148800194 0.0104195741475089 0.0 0.0 0.0 0.0 51 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +605334 COL4A2 CD93 COL4A2-CD93 B Cells Pericytes B Cells -> Pericytes 0.0110533132352417 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0033449520260795 0.1281708518900828 0.0 0.0023121387283236 0.0654068346930415 0.0 1211 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +605441 CCN1 CAV1 CCN1-CAV1 Pericytes B Cells Pericytes -> B Cells 0.0110521843845445 0.9219165193585238 0.62431395375366 0.6198216015396206 0.2646489893253856 0.0019304335593669 0.0 0.0041392285983066 1.0 0.0 1063 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +606043 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0110448190961635 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0491302556793708 0.0125623889131764 0.0 0.0003980891719745 0.1848263841442555 0.0 157 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +606131 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0110435889463513 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.0200499113739789 0.040323117011325 0.0 0.0013440860215053 0.0934882074160484 0.0 496 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +606185 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0110429137984394 0.4625081978296446 0.4642836810638544 0.8293805866303694 0.0704104148800194 0.0144613249009303 0.0 0.0098934550989345 0.0573348975469485 0.0 219 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +606528 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0110389133176582 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.1932385901170197 0.0030676679668133 0.0 0.0013940520446096 0.9085766810436258 0.0 2152 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +606532 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0110388531991463 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.4103175828613323 0.001079730675535 0.0 0.0041283689048138 0.6354601188192218 0.0 917 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +606536 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0110387804260989 0.6342079770588467 0.6580560501976399 1.0 0.002196330917593 0.1973932010691654 0.0 0.0021710402114404 0.0388566826407454 0.0 5297 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +606562 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0110384106686001 0.662063103571249 0.2491073778594529 0.2461374514707439 0.585843718590581 0.0076066460958003 0.0 0.0 0.0 0.0 184 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +606629 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0110375038671339 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0338862305197021 0.0215025911544899 0.0 0.0008900190718372 0.1069230409099883 0.0 715 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +606682 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0110367984173053 0.6213271600240247 0.62431395375366 0.8693461273411047 0.0083518627398662 0.0641739251983978 0.0 0.000669344042838 0.063584453947475 0.0 1245 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +606730 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0110361051867114 0.8023917560710954 0.9546923450729716 0.6198216015396206 0.0085367158000785 0.0445745465878424 0.0 0.0027688047992616 0.1025431531044997 0.0 394 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +606963 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0110331399723522 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0361307801045652 0.0176963220730796 0.0 0.0010978956999085 0.1454147034296964 0.0 1093 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +606980 C3 LRP1 C3-LRP1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0110329247474257 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0091898156146168 0.0416128058995347 0.0 0.0005267979844251 0.0492032667426581 0.0 2183 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +607485 VWF ITGA9 VWF-ITGA9 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0110266569575314 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0036144684673052 0.1347191569099048 0.0 0.0008694540340109 0.0376851564474372 0.0 3555 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +607518 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0110261921619756 0.6160088550075702 0.8950084308969304 0.7917001487310438 0.0009692519480124 0.4247538686915498 0.0 0.001739886907351 0.0179355947826077 0.0 209 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +607754 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0110230190967898 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.00263399584678 0.1993723722552783 0.0 0.001325381047051 0.0579228568388818 0.0 1509 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +607755 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0110230158343402 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0425206505665654 0.0144613249009303 0.0 0.0021097046413502 0.0122262342383463 0.0 474 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +607814 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0110222518642744 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0170183763647696 0.0350138403862125 0.0 0.0011004660797514 0.0386875178867989 0.0 1931 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +608038 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.011019152345699 0.6582846571368821 0.8347945881127203 0.6198216015396206 0.4344545964241579 0.0012097093680331 0.0 0.0184615384615384 1.0 0.0 130 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +608084 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.011018592818755 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.016822895653248 0.026308073552735 0.0 0.0017182130584192 0.1252301013368955 0.0 97 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +608144 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0110179746222343 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.018132161410931 0.0521374123931907 0.0 0.00151171579743 0.2689466931117103 0.0 1323 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +608478 CD48 CD2 CD48-CD2 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0110139242371029 0.928447473463448 0.6614977577544194 0.7917001487310438 1.0 0.0003671083100858 0.0 0.0 0.0 0.0 81 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +608649 COL4A1 CD93 COL4A1-CD93 Macrophages Macrophages Macrophages -> Macrophages 0.0110121419241378 0.9102252263107924 0.944024288971064 1.0 0.0042860632265532 0.0484215930647349 0.0 0.0009589678019295 0.032495210023632 0.0 2458 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +608866 COL4A2 CD93 COL4A2-CD93 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0110097050809857 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.0047240947268779 0.1281708518900828 0.0 0.002433628318584 0.068843587622156 0.0 452 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +608920 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.011009047086659 0.7487535481622718 0.8628183098412396 0.6198216015396206 0.0131092554497256 0.0339152418223636 0.0 0.0004095004095004 0.0312867764187305 0.0 1332 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +609105 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0110067557288397 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.1496557267835524 0.0062523288579129 0.0 0.0097087378640776 0.1147501931870342 0.0 103 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +609376 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0110033693620373 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.0142750905665976 0.0416128058995347 0.0 0.0053104575163398 0.3150156859999027 0.0 714 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +609503 A2M LRP1 A2M-LRP1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0110015212162689 0.919551140852988 0.9078204025796472 0.8875000050982297 0.037376181609614 0.0064028969591119 0.0 0.0017384860921112 0.2447479719858651 0.0 1462 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +609794 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0109978621208441 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0135527119637784 0.0350138403862125 0.0 0.0011560409287682 0.0406412836638217 0.0 2541 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +609821 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0109975306566591 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0170183763647696 0.0587195251380622 0.0 0.0002821393523061 0.0240454298671298 0.0 5095 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +609894 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0109965566455063 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.7029371915698084 0.00071798405859 0.0 0.0001969124133585 0.1490640459875829 0.0 4232 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +610593 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0109874437917955 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0515877972474039 0.0104714078116759 0.0 7.557436517533252e-05 0.0075586294958931 0.0 827 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +610599 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0109874266566794 0.9184503888425788 0.6580560501976399 0.6198216015396206 0.0004696576149175 1.0 0.0 0.0001759633996128 0.0095663175493171 0.0 5683 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +611266 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0109785730643264 0.6160088550075702 0.8622452992050237 0.8693461273411047 0.0149256517769723 0.0254056950469408 0.0 0.0015334063526834 0.2409449977915881 0.0 1245 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +611412 CD48 CD2 CD48-CD2 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0109768052779622 0.9426443637490616 0.8581827408615759 0.8693461273411047 0.0632786830726401 0.003930762149527 0.0 0.0 0.0 0.0 360 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +611541 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.010974966314327 0.6319926036888139 0.8604147465201248 0.6198216015396206 0.011891719340537 0.0436001007095475 0.0 0.0002775721687638 0.007935580340017 0.0 1351 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +611883 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0109704607429668 0.6582846571368821 0.6587114738285964 0.8824495942126559 0.1740454925211078 0.0026174949623928 0.0 0.0002845902737088 0.0386091227762996 0.0 11947 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +611926 COL4A1 CD93 COL4A1-CD93 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0109697900845289 0.7766289238087107 0.8817184225858201 0.8567148457705164 0.0002970267018348 1.0 0.0 0.0049171842650103 0.0375289782671921 0.0 276 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +611947 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0109695211665384 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.0227314494836465 0.040323117011325 0.0 0.0010886777513855 0.0757232273844952 0.0 1684 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +612127 C3 LRP1 C3-LRP1 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.0109675116906459 0.8911088195487638 0.9078204025796472 0.946515890536252 0.0064915662046245 0.0350138403862125 0.0 0.0007755514544336 0.0681294974925549 0.0 11379 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +612185 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0109666864824931 0.8771078809726828 0.6580560501976399 0.6198216015396206 0.0080232294691882 0.0606066271159369 0.0 0.0012919896640826 0.0309771228000732 0.0 129 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +612238 COL4A2 CD93 COL4A2-CD93 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0109659388753804 0.7783550150988336 0.7779918296243433 0.909150863993142 0.0267593032157803 0.0118035014556376 0.0 0.0006924505995608 0.0700746466933455 0.0 5921 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +612599 CCN1 CAV1 CCN1-CAV1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0109614065650016 0.7324582304061453 0.7283139964676212 0.8767341187813953 0.0025580826958339 0.1449812920932466 0.0 0.0008027210884353 0.0657971994647936 0.0 2450 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +612603 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0109613533465957 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0052560850129547 0.1176565474247238 0.0 0.0021339220014716 0.1465784555960956 0.0 453 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +612764 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0109589673063983 0.6249837837987587 0.7746834992804791 0.909150863993142 0.0435116250366991 0.0090444648829713 0.0 0.0004770992366412 0.0671279002141306 0.0 5764 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +613291 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0109522670957356 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0037159398684439 0.1281708518900828 0.0 0.001863354037267 0.0439060518338779 0.0 345 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +613399 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0109508223969081 0.6342079770588467 0.6571792026963191 0.8824495942126559 0.0673400749834054 0.0069630688870869 0.0 0.0004281738385784 0.0540658269937047 0.0 4671 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +614128 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0109420637719678 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0131302879503246 0.0335947364052305 0.0 0.0002748158733648 0.0147013052644184 0.0 827 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +614152 CD34 SELP CD34-SELP CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0109417849359665 0.7168245244832976 0.4623922682986163 0.8293805866303694 0.1173076386135379 0.0053213839468185 0.0 0.0008076728924785 0.3163670813970107 0.0 9905 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +614161 CCN1 CAV1 CCN1-CAV1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0109416743289122 0.8749036366850302 0.9694036398779844 0.8567148457705164 0.0004337320404416 0.5444650460041837 0.0 0.0015027322404371 0.0299193428213638 0.0 244 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +614233 C3 LRP1 C3-LRP1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0109408720786473 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0334108479684367 0.0144359394371152 0.0 0.0006029781879194 0.1029734163176713 0.0 4768 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +614767 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0109345593857488 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0208904415011529 0.0292771742399634 0.0 0.0004227436060029 0.0484291675003477 0.0 1577 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +614804 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0109339753218467 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.1357656553382984 0.0032187363284526 0.0 0.0002008569898232 0.0395648289478849 0.0 1867 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +615005 VEGFC FLT1 VEGFC-FLT1 Pericytes Mast Cells Pericytes -> Mast Cells 0.0109317076990618 0.8718210606749883 0.8331580262014722 0.8567148457705164 0.1796394187986057 0.001526625481682 0.0 0.0014814814814814 0.6966889319830499 0.0 225 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +615311 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0109278967173437 0.6630837220165452 0.8347945881127203 0.6198216015396206 0.4103175828613323 0.0012097093680331 0.0 0.0192307692307692 1.0 0.0 130 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +615413 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0109265786558123 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0135527119637784 0.0416128058995347 0.0 0.001521674584323 0.0602870227869745 0.0 1684 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +615596 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0109243344944137 0.8718210606749883 0.878254460598671 0.9429656149619918 0.0017670878089588 0.1332188634280341 0.0 0.0015019680961259 0.0566094133697649 0.0 3218 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +615803 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0109218941331921 0.6160088550075702 0.6631822525600675 1.0 0.0106340017102282 0.0390724515618796 0.0 5.224339802217456e-05 0.0295185195678606 0.0 423716 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +615821 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0109216787961662 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.3309594876493178 0.0028784826949613 0.0 0.0035169289461134 0.260043918865431 0.0 233 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +616092 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0109182318274363 0.6213271600240247 0.943345641464811 0.6198216015396206 0.1339639999453202 0.0034806998160403 0.0 0.0002459016393442 0.0910346800191499 0.0 4880 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +616199 DLL1 NOTCH3 DLL1-NOTCH3 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0109170899321954 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.00263399584678 0.1973932010691654 0.0 0.0008608815426997 0.0156275228088608 0.0 968 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +616220 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0109168122500373 0.9468422434493456 0.7830372268649692 0.7827641335561659 0.1120119983652299 0.0026038611777234 0.0 0.0036919831223628 0.3141788023645963 0.0 316 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +616682 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0109115418129669 0.4636527906642655 0.777821334064334 0.6198216015396206 0.0693389464442948 0.0108892901157311 0.0 0.000868531724264 0.1077753801447994 0.0 3646 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +617091 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0109065341540707 0.7797302331085993 0.657421674383923 0.7917001487310438 0.0699064461360958 0.0059327142047454 0.0 0.0005732301519059 0.1535952056225929 0.0 1163 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +617333 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0109032709536081 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0020251995753771 0.2898144908728011 0.0 0.0005529405092723 0.0128419543741397 0.0 6412 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +617615 VWF ITGA9 VWF-ITGA9 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0108996556006757 0.7158082793127664 0.9404022517663844 0.7204611100467462 0.0003457348439318 1.0 0.0 0.0030529172320217 0.034088850000805 0.0 536 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +617820 MMP2 PECAM1 MMP2-PECAM1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0108968153074858 0.9330801352629944 0.6331674633943454 0.6198216015396206 0.0088108219576754 0.0518891167572028 0.0 0.0018672199170124 0.0681736212948689 0.0 1687 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +617836 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0108966255894278 0.4625081978296446 0.657421674383923 0.6198216015396206 0.149715856631667 0.0059327142047454 0.0 0.0 0.0 0.0 135 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +617988 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0108947292816074 0.7840818683779507 0.6571792026963191 0.6198216015396206 0.0032417203409647 0.1615138601457002 0.0 0.0017331022530329 0.1656547208535461 0.0 1154 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +618026 VWF LRP1 VWF-LRP1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0108941727206416 0.7848266128497919 0.7346293219749174 0.7204611100467462 0.0004024409845247 1.0 0.0 0.0013615416841223 0.0104532507434172 0.0 1302 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +618211 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0108917917604008 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0020251995753771 0.2879885658616873 0.0 0.0006818181818181 0.0251260883413991 0.0 800 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +618417 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0108888877799461 0.6213271600240247 0.252518874138558 0.2461374514707439 0.1339639999453202 0.0322196586137726 0.0 0.0003623188405797 0.0634044017982654 0.0 184 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +618556 CCN1 CAV1 CCN1-CAV1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0108870252822428 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0083518627398662 0.0649213179279442 0.0 0.0012293344637558 0.050650186695839 0.0 2359 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +618602 THBS2 CD36 THBS2-CD36 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0108863936375491 0.8581959463413404 0.8587566561291643 0.8567148457705164 0.0002636300075004 1.0 0.0 0.0031702898550724 0.0455203256047385 0.0 276 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +618764 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0108842308312661 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0161193721503025 0.0326412663903893 0.0 0.0005576679340937 0.2259533273884015 0.0 3945 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +618794 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0108837970451 0.2485046029682279 0.7346293219749174 0.2461374514707439 0.0036991419150414 1.0 0.0 0.0012912482065997 0.0228747319298396 0.0 4879 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +619385 COL4A1 CD93 COL4A1-CD93 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0108755627900542 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0126216524880575 0.0289462771086338 0.0 0.0001839362354383 0.0271846511344078 0.0 1165 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +619691 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0108717634253366 0.8840293712888387 0.7779918296243433 0.6198216015396206 0.0061698665784747 0.0627790816848129 0.0 0.000901916572717 0.0197803199518531 0.0 887 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +619780 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0108705902875716 0.7158082793127664 0.9404022517663844 0.7204611100467462 0.0025256125075084 0.1347191569099048 0.0 0.0006591026787816 0.0285677984035847 0.0 1931 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +619871 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.010869363450878 0.8667347161816407 0.8960994285623033 0.8693461273411047 0.0106228227237899 0.0229905310518441 0.0 0.0 0.0 0.0 1044 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +619906 VWF ITGA9 VWF-ITGA9 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0108688919329621 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0019871862905238 0.2898144908728011 0.0 0.0007725985063095 0.0179434760180832 0.0 1412 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +620356 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0108632995668312 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0172764782878141 0.0289462771086338 0.0 0.0005129562828871 0.1060758937645968 0.0 30217 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +620556 C1QB LRP1 C1QB-LRP1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.0108607708877811 0.7753420160918723 0.9078204025796472 1.0 0.0161519521398178 0.0144359394371152 0.0 0.0003619219031223 0.0338211398052356 0.0 12779 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +620560 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0108606803148473 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0106340017102282 0.0521257226458961 0.0 0.0004710315591144 0.0196996490267063 0.0 1351 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +620575 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0108604608870601 0.8516956437178343 0.6580560501976399 0.6198216015396206 0.000472352586488 1.0 0.0 0.0 0.0 0.0 78 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +620768 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0108581452896299 0.7797302331085993 0.4642836810638544 0.2461374514707439 0.0200499113739789 0.0917308979735958 0.0 0.0023696682464454 0.1303925886889263 0.0 211 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +620826 VWF ITGA9 VWF-ITGA9 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0108574489347114 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0019871862905238 0.2879885658616873 0.0 0.0003542620449095 0.0130551218400554 0.0 3336 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +620909 CCN1 CAV1 CCN1-CAV1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0108563904922361 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0083518627398662 0.0638329144736252 0.0 0.000253485424588 0.0661744876320834 0.0 3945 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +621054 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0108544405493635 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0106922602624424 0.0326667674102811 0.0 0.0060526315789473 0.1209495589474899 0.0 285 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +622002 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0108425795737972 0.4604235282221027 0.8817184225858201 0.2461374514707439 0.0126864732057784 0.1281708518900828 0.0 0.0011932192231731 0.0281157225165097 0.0 1736 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +622134 CD48 CD2 CD48-CD2 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0108409241966319 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0164675938709007 0.0229905310518441 0.0 0.000942507068803 0.0444364330606055 0.0 2122 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +622353 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0108380410126645 0.8771078809726828 0.4638256179742202 0.7204611100467462 0.0080232294691882 0.0689186266365139 0.0 0.0004100881689563 0.0499683369206933 0.0 9754 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +623387 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Macrophages Pericytes -> Macrophages 0.0108252405935752 0.9184503888425788 0.8923034233058523 0.8875000050982297 0.1169448695751571 0.00189193058407 0.0 0.0006274509803921 0.2775822159463469 0.0 2125 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +623876 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.01081919143081 0.662063103571249 0.6331674633943454 0.8824495942126559 0.585843718590581 0.0007400708115376 0.0 0.0002339850249584 0.0456716811179803 0.0 12020 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +623894 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0108190164386983 0.7745997874735252 0.777821334064334 0.8693461273411047 0.016822895653248 0.0182001711419816 0.0 0.0002261420171867 0.0270855878477101 0.0 737 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +624072 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0108169937251798 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0097699360831605 0.0518891167572028 0.0 0.0009374999999999 0.0342288390251321 0.0 3360 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +624264 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Pericytes Macrophages -> Pericytes 0.0108144698647915 0.7487535481622718 0.7757991160529997 0.8875000050982297 0.0338862305197021 0.0091569531245039 0.0 0.0011942382597192 0.3125872592855257 0.0 2474 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +624335 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0108134888083091 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0053032910137447 0.0855781119790033 0.0 0.002218524681087 0.1117913332835153 0.0 1803 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +624524 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0108111578321531 0.6605327397359113 0.7763400818577846 0.7917001487310438 0.0179229861158654 0.0219439768073448 0.0 0.0005616399887672 0.0771112063482367 0.0 1187 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +624695 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0108089012728642 0.6582846571368821 0.4630027772793905 0.2461374514707439 0.4344545964241579 0.0048929293424311 0.0 0.0012903225806451 0.4172169297735012 0.0 155 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +624751 VWF LRP1 VWF-LRP1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0108080688577262 0.7158082793127664 0.7346293219749174 0.8767341187813953 0.0003457348439318 1.0 0.0 0.0019573283858998 0.015027409475317 0.0 2450 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +625521 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.010798465076967 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0070532058552773 0.0587195251380622 0.0 0.000798760133524 0.0563173124294638 0.0 1165 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +625905 HSPG2 LRP1 HSPG2-LRP1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0107937203863888 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.1619074107723045 0.0028784826949613 0.0 0.0051996091568955 0.3844623426987127 0.0 398 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +625956 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0107932169905226 0.7800321422220979 0.6331674633943454 1.0 0.1357656553382984 0.0023576674662702 0.0 0.0003320392317123 0.1030764130261103 0.0 19576 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +626033 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0107919601518812 0.4625081978296446 0.657421674383923 0.2461374514707439 0.3558005706994493 0.0059327142047454 0.0 0.0 0.0 0.0 26 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +626131 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0107907437938184 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0967042147306326 0.0049190726392343 0.0 0.0019765539803707 0.3996783290215145 0.0 917 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +626330 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0107881739648611 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0131092554497256 0.0390724515618796 0.0 8.798169980644026e-05 0.049711343933787 0.0 5683 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +626342 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0107880593044217 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0131092554497256 0.0484993884807927 0.0 0.0127591706539074 0.1813904973015966 0.0 285 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +626363 C1QB LRP1 C1QB-LRP1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0107877492673796 0.8703788833238396 0.8755243548400705 0.6198216015396206 0.8040181448318822 0.0004150165744076 0.0 0.0053807947019867 0.6660084205819893 0.0 151 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +626411 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0107871671017196 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0131302879503246 0.0416128058995347 0.0 0.0003675629038789 0.0152400479237297 0.0 5163 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +626545 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0107853212540382 0.6605327397359113 0.4642836810638544 0.2461374514707439 0.0227314494836465 0.0917308979735958 0.0 0.0 0.0 0.0 155 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +626628 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0107840243229586 0.6213271600240247 0.62431395375366 0.8824495942126559 0.1339639999453202 0.0034299077593249 0.0 0.0001885745978924 0.0195077170233518 0.0 12020 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +626642 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0107839266247806 0.6582846571368821 0.944024288971064 0.6198216015396206 0.0084325366891025 0.0484215930647349 0.0 0.0016806722689075 0.0622781038387856 0.0 119 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +626675 VWF SELP VWF-SELP Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.01078362451171 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0003457348439318 1.0 0.0 0.0021200814111261 0.0119211622933213 0.0 536 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +626842 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0107815188888477 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0637288077574987 0.0080072638027924 0.0 0.00147741663149 0.3568712520329796 0.0 2369 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +627357 CD34 SELP CD34-SELP CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0107744979182006 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.1173076386135379 0.0045674276780054 0.0 0.0 0.0 0.0 233 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +627363 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0107744525298272 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0110717612136884 0.0397596998227057 0.0 0.0008375209380234 0.0642686030067933 0.0 398 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +627738 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0107694520062571 0.6593525851613742 0.777821334064334 0.7917001487310438 0.0120646829101097 0.0318483483218543 0.0 0.0 0.0 0.0 69 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +628126 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0107643188965299 0.7789175740361626 0.6207977546603366 0.909150863993142 0.0070532058552773 0.0501711964086628 0.0 0.001144556249518 0.0194198103337112 0.0 5764 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +628592 CD34 SELP CD34-SELP Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0107585088465503 0.7871981482311898 0.8819126042133903 0.7827641335561659 0.0038506427265089 0.0741032966028748 0.0 0.0 0.0 0.0 389 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +628738 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0107564285233317 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0106340017102282 0.0491709261488903 0.0 0.000538321781845 0.0242931024845603 0.0 1351 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +629092 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0107516558848528 0.7487535481622718 0.4600037439857229 0.2461374514707439 0.1027229557481577 0.017738069381683 0.0 0.001117196056955 0.2785282601346565 0.0 2075 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +629178 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.010750576792916 0.6589792304505506 0.6207977546603366 0.8824495942126559 0.0072827533047186 0.0587195251380622 0.0 0.0005692826120889 0.0401377902828327 0.0 12101 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +629218 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0107501224682371 0.662063103571249 0.6331674633943454 0.9161861017439124 0.0967042147306326 0.0041555861088636 0.0 0.0013070342205323 0.1659924371063173 0.0 526 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +629912 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0107408585898977 0.4648000335061383 0.8604147465201248 0.2461374514707439 0.0357762282281787 0.0436001007095475 0.0 0.003003003003003 0.0860286846015678 0.0 222 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +629931 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0107405659373328 0.7482742921073442 0.944024288971064 0.7827641335561659 0.005733874009046 0.0484215930647349 0.0 0.0030864197530864 0.1143687400743131 0.0 162 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +629994 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.010739805559184 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0186793449598515 0.0238720285974944 0.0 0.0006032402619786 0.1470481467489398 0.0 11604 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +630542 CD48 CD2 CD48-CD2 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.010732705134662 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0212837736082081 0.0226890201466244 0.0 0.0002875215641173 0.0416733998420524 0.0 1739 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +630634 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.010731401694528 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2966815529783992 0.0028784826949613 0.0 0.0005364806866952 0.0867190605680937 0.0 233 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +630684 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0107308257223559 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0028649117803088 0.1615138601457002 0.0 0.0005069708491761 0.0484576800671716 0.0 3945 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +630766 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0107296755414645 0.7840818683779507 0.896164124004365 0.7827641335561659 0.0032417203409647 0.0855781119790033 0.0 0.0 0.0 0.0 389 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +630954 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.010727114088143 0.4604235282221027 0.8347945881127203 0.7204611100467462 0.454846709299195 0.0012097093680331 0.0 0.0025085819910219 0.1385171989945558 0.0 1082 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +631491 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0107199609999644 0.6160088550075702 0.8628183098412396 0.7917001487310438 0.0106340017102282 0.0339152418223636 0.0 0.0001076555023923 0.0082251288532399 0.0 30400 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +631541 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0107193868486562 0.6630837220165452 0.4630027772793905 0.2461374514707439 0.4103175828613323 0.0048929293424311 0.0 0.0013824884792626 0.3720180579786931 0.0 155 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +631953 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0107141617568958 0.6332974881236617 0.6252253442669611 1.0 0.0020251995753771 0.1886404570313 0.0 0.0003204294683657 0.0083802661837869 0.0 19576 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +632101 COL4A2 CD93 COL4A2-CD93 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0107122998398639 0.8840293712888387 0.4630027772793905 0.7204611100467462 0.5544396796022323 0.0009242223287825 0.0 0.0038071065989847 0.7260182294373562 0.0 394 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +632103 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0107122884475546 0.8023917560710954 0.9460955677032749 0.6198216015396206 0.0085367158000785 0.0376195773145198 0.0 0.0012690355329949 0.0461723582163967 0.0 394 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +632523 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0107071776685134 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0031934983073077 0.1341680150528327 0.0 0.0012189404594467 0.0303533538343133 0.0 3555 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +632657 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0107053981913881 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.1882781599600688 0.0023576674662702 0.0 0.00125250501002 0.3888206916523692 0.0 1996 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +632679 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0107050023409295 0.8718210606749883 0.6593689120110077 0.6198216015396206 0.0017670878089588 0.2390217618875283 0.0 0.0002346178661505 0.0232307621097841 0.0 5683 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +632900 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0107023591086465 0.7766289238087107 0.944024288971064 0.8875000050982297 0.0047694898966413 0.0484215930647349 0.0 0.0008527287319422 0.0288952342110888 0.0 1424 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +632937 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.010701935247229 0.743507317541692 0.6593689120110077 0.6198216015396206 0.0020684923107111 0.2390217618875283 0.0 0.0011554015020219 0.1144024446013028 0.0 1154 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +633117 CD48 CD2 CD48-CD2 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0106996499379497 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0351142257737683 0.0226890201466244 0.0 0.0007626601586333 0.110540027951997 0.0 3278 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +633888 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0106897907795928 0.6659645551150886 0.8960994285623033 0.7917001487310438 0.0137371823984124 0.0229905310518441 0.0 0.0 0.0 0.0 209 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +633902 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0106896105748246 0.4648000335061383 0.6207977546603366 0.2461374514707439 0.0357762282281787 0.0587195251380622 0.0 0.0 0.0 0.0 186 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +634143 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0106867154724975 0.6593525851613742 0.777821334064334 0.7917001487310438 0.0201572483258557 0.0182001711419816 0.0 0.0008939974457215 0.1070762817673077 0.0 1305 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +634195 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0106859489674141 0.7840818683779507 0.4638256179742202 0.2461374514707439 0.0032417203409647 0.5131068416842878 0.0 0.0040983606557377 0.0931033269208274 0.0 122 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +634303 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0106846335822595 0.6561647292424944 0.6207977546603366 0.8824495942126559 0.0070489045197697 0.0587195251380622 0.0 0.0005135097877033 0.0660273932583665 0.0 12090 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +634431 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.01068310782514 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0548063857429699 0.0091569531245039 0.0 0.0029158169654037 0.7632038467835179 0.0 2541 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +634634 CD34 SELP CD34-SELP CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0106806603746915 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.1173076386135379 0.0036702914086929 0.0 0.0009727626459143 0.3978418442421935 0.0 1542 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +635053 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0106760498127675 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.011891719340537 0.0350138403862125 0.0 0.0002894229082617 0.025424795724359 0.0 5701 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +635076 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0106757688297409 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0073929685753755 0.0606066271159369 0.0 0.0103092783505154 0.2919005665784127 0.0 97 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +635518 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0106700352826269 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0526353932596327 0.0073658308476012 0.0 0.0055478502080443 1.0 0.0 103 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +635608 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0106687320661742 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0161193721503025 0.0326667674102811 0.0 0.0077405857740585 0.1546798980172557 0.0 239 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +635767 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0106668351198328 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.0141498126994191 0.0467761235673353 0.0 0.0026455026455026 0.1487713446791528 0.0 315 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +636161 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.010662130232346 0.9184503888425788 0.4641352222874551 0.7204611100467462 0.1169448695751571 0.0040904475843412 0.0 0.0050761421319796 0.5338378889752343 0.0 394 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +636398 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.010658883274016 0.6605327397359113 0.8381155706134242 0.6198216015396206 0.1468839381042521 0.0029095741067474 0.0 0.0333333333333333 1.0 0.0 5 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +636601 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0106562338945339 0.255669001367946 0.8950084308969304 0.2461374514707439 0.0061207051981986 0.4247538686915498 0.0 0.0032512192072026 0.0335151382560833 0.0 727 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +636648 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0106556998471023 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0141923232885854 0.0326412663903893 0.0 0.000107296137339 0.0434737551964126 0.0 1165 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +636734 CD48 CD2 CD48-CD2 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0106546188634749 0.9426443637490616 0.7763428264267787 0.6198216015396206 0.0632786830726401 0.0050968401714881 0.0 0.0009940357852882 0.2529760335110254 0.0 1509 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +637184 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0106488027407438 0.6213271600240247 0.943345641464811 0.6198216015396206 0.1153131738111426 0.0034806998160403 0.0 0.0008115419296663 0.3004390702164911 0.0 1109 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +637680 COL4A2 CD93 COL4A2-CD93 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0106426089246948 0.8840293712888387 0.6587114738285964 0.6198216015396206 0.5544396796022323 0.0007261054236978 0.0 0.0010610079575596 0.1629452547865773 0.0 377 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +637759 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0106416585651249 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0113788029360913 0.0326412663903893 0.0 0.0001425855513307 0.0485699939831313 0.0 3945 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +637849 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.010640583860893 0.8730912658940219 0.7754239189773715 0.7204611100467462 0.0057086106530109 0.0521257226458961 0.0 0.0087671971944968 0.3666648324036077 0.0 337 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +638747 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0106287959981418 0.7487535481622718 0.7447682696221608 0.7827641335561659 0.1027229557481577 0.0032154705418133 0.0 0.0069220119981541 0.5875693845084453 0.0 394 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +638950 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0106262012280375 0.8911088195487638 0.8604147465201248 0.8875000050982297 0.0048525806497539 0.0436001007095475 0.0 0.0027212078651685 0.0777972940590482 0.0 1424 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +639051 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0106249920832252 0.9470274865242416 0.6580560501976399 0.6198216015396206 0.0061455194924501 0.0606066271159369 0.0 0.0006410256410256 0.0153694186200363 0.0 390 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +640105 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0106119222907418 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0323110954490285 0.0083242517891534 0.0 0.0027605244996549 0.3229433589842481 0.0 69 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +640354 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.010608835025748 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0411214967239829 0.0090444648829713 0.0 0.0010332050733931 0.1453720352934201 0.0 2339 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +640551 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0106068521982544 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.011891719340537 0.0416128058995347 0.0 0.00027600232423 0.0257787925963826 0.0 5163 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +640821 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0106037829725115 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0526353932596327 0.0070956399217802 0.0 0.0086066088704611 1.0 0.0 379 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +641662 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0105938193165521 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0172764782878141 0.0292771742399634 0.0 0.00125 0.1431989946525908 0.0 800 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +641767 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0105924999024764 0.6249837837987587 0.8923034233058523 0.6198216015396206 0.2159908053119969 0.00189193058407 0.0 0.0001850481125092 0.0698269280835585 0.0 1351 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +641939 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0105904857382389 0.6659645551150886 0.6614977577544194 0.8824495942126559 0.1496557267835524 0.0024251058581756 0.0 0.0 0.0 0.0 4671 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +641965 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0105901405373772 0.2451358214448441 0.663300745568453 0.2461374514707439 0.1327555461750915 0.0265498740402422 0.0 0.0137362637362637 0.348969636453961 0.0 26 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +642051 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.010588961527254 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0031934983073077 0.1281708518900828 0.0 0.0019690576652601 0.040666801898823 0.0 3555 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +642169 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0105874909504291 0.743507317541692 0.878254460598671 0.7827641335561659 0.0020684923107111 0.1332188634280341 0.0 0.001713796058269 0.0645932425224371 0.0 389 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +642583 C3 LRP1 C3-LRP1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0105824282231139 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0616816618657801 0.0064028969591119 0.0 0.0010402684563758 0.1970830531861907 0.0 1490 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +642811 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0105798122146746 0.6303642896310324 0.9015117569158254 0.6198216015396206 0.0161193721503025 0.0246995741084876 0.0 0.0019442743417023 0.0989617380771964 0.0 1633 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +642913 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0105785074868585 0.8023917560710954 0.6632137581773894 0.6198216015396206 0.0085367158000785 0.049767778498468 0.0 0.0001248996342224 0.0426838846032244 0.0 5095 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +642966 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0105779620259524 0.9184503888425788 0.6571792026963191 0.6198216015396206 0.1169448695751571 0.0032020139126304 0.0 0.0026525198938992 0.8556149732620323 0.0 377 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +643497 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.010571514411791 0.8624864526942296 0.6580560501976399 0.6198216015396206 0.0020100505037262 0.1973932010691654 0.0 0.0034722222222222 0.0630310086624054 0.0 144 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +643950 CD48 CD2 CD48-CD2 Mast Cells B Cells Mast Cells -> B Cells 0.0105657561279881 0.7719609236370527 0.937587088419394 0.6198216015396206 0.0112468593062777 0.0275738893167071 0.0 0.0 0.0 0.0 112 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +644258 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0105618339945487 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0236359933700329 0.0176963220730796 0.0 0.0018115942028985 0.3311675697437269 0.0 69 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +644399 MMP2 PECAM1 MMP2-PECAM1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0105601339031071 0.9330801352629944 0.7167436199046466 0.7204611100467462 0.0088108219576754 0.0326667674102811 0.0 0.0061349693251533 0.1225949117099124 0.0 326 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +644475 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0105594079140972 0.4625081978296446 0.885766439573873 0.7204611100467462 0.0141498126994191 0.0331922776397286 0.0 0.001865671641791 0.2071109867989895 0.0 536 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +644712 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0105567936575996 0.9097736029185508 0.773263018678637 0.6198216015396206 0.0430965463818576 0.0073658308476012 0.0 0.002907268170426 0.529339410376961 0.0 475 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +644906 CXCL12 CXCR4 CXCL12-CXCR4 B Cells B Cells B Cells -> B Cells 0.0105547798453767 0.6160088550075702 0.9546923450729716 1.0 0.0052742025956585 0.0445745465878424 0.0 0.0032055391716886 0.1187176843064554 0.0 1418 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +644927 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0105546271163102 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0492631209980634 0.0064028969591119 0.0 0.0010269512072938 0.1215208615750498 0.0 1109 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +645660 COL4A2 CD93 COL4A2-CD93 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0105458156613133 0.8840293712888387 0.8817184225858201 0.9429656149619918 0.5544396796022323 0.0003375370073613 0.0 0.000944032366824 0.7334167889664893 0.0 2966 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +645792 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0105441986970434 0.6582846571368821 0.7461459456652184 0.6198216015396206 0.4344545964241579 0.0010390313650636 0.0 0.0055944055944055 0.8203804149792303 0.0 143 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +645856 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.010543502017681 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.0179229861158654 0.040323117011325 0.0 0.0003679175864606 0.0255905909924724 0.0 453 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +646262 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0105384447776945 0.8730912658940219 0.7757991160529997 0.7204611100467462 0.0057086106530109 0.0491709261488903 0.0 0.0067439978419206 0.3043395906587637 0.0 337 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +646632 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0105336761279562 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0110717612136884 0.0293997450046583 0.0 0.0002111040743086 0.0130154506032576 0.0 1579 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +646649 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0105334312692116 0.8949858186325867 0.6580560501976399 0.6198216015396206 0.001895566065636 0.1973932010691654 0.0 0.0006154603643525 0.0110153409087421 0.0 1354 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +646699 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0105327924163233 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0265972645862203 0.0144359394371152 0.0 0.0002068557919621 0.0353257348444711 0.0 1692 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +646850 MMP2 PECAM1 MMP2-PECAM1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0105309238894559 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0216588811659259 0.0176963220730796 0.0 0.0012119843420656 0.1605255796863015 0.0 3321 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +647087 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Dendritic Cells Pericytes -> Dendritic Cells 0.0105282904033405 0.9468422434493456 0.6347970925105053 0.6198216015396206 0.1120119983652299 0.003263637675389 0.0 0.004010977411864 0.404199796085524 0.0 1579 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +647849 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0105186101137057 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0255753403203798 0.0178869147172998 0.0 0.001706452104942 0.2917204434588946 0.0 4768 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +647857 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0105185080782867 0.6160088550075702 0.9008184599638702 0.7917001487310438 0.0009692519480124 0.3180524283074206 0.0 0.0008699434536755 0.0120892684264055 0.0 209 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +648487 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0105109440022569 0.4636527906642655 0.4630488285702799 0.8293805866303694 0.014525360548861 0.0521374123931907 0.0 0.0008105229030614 0.1441987011316954 0.0 7197 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +648632 CD34 SELP CD34-SELP Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0105090333570573 0.9303167350027568 0.4623922682986163 0.2461374514707439 0.1314667522621683 0.0096770075292062 0.0 0.000261917234154 0.2376241127804487 0.0 1909 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +649036 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0105036889031101 0.8533682807143209 0.6587114738285964 0.7917001487310438 0.0706049302656684 0.0042738820064046 0.0 0.00168337286709 0.1216634585466078 0.0 1867 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +649191 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.010501946359554 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0016171311116606 0.2898144908728011 0.0 0.0010796804145972 0.0250754039365929 0.0 1684 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +649205 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0105018303098857 0.633566764858408 0.6572093097629401 0.8824495942126559 0.0799339500711946 0.0045674276780054 0.0 0.0002511090650372 0.0767079328494791 0.0 11947 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +649211 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.010501786467546 0.4636527906642655 0.8998347793593909 0.7204611100467462 0.0693389464442948 0.0064362797035136 0.0 0.0005312084993359 0.1924690692088509 0.0 10040 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +649362 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0104997906290455 0.6593525851613742 0.777821334064334 0.7917001487310438 0.018132161410931 0.0182001711419816 0.0 7.744733581164808e-05 0.0092760586634583 0.0 2152 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +649655 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0104960433774707 0.4630253981438691 0.4630027772793905 0.8767341187813953 0.7696906278989153 0.0009242223287825 0.0 0.0015083571137382 0.2876448905758331 0.0 2453 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +649687 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0104956350426545 0.7324582304061453 0.7832252605020791 0.7204611100467462 0.2376713873232418 0.00136079311934 0.0 0.0006535947712418 0.0960790407533572 0.0 51 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +649971 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0104922043295515 0.7797302331085993 0.8381155706134242 0.6198216015396206 0.1132020978253244 0.0029095741067474 0.0 0.0077262693156732 0.244041452079095 0.0 151 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +650052 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.010491244486608 0.9097736029185508 0.773263018678637 0.6198216015396206 0.0430965463818576 0.0070956399217802 0.0 0.0033806090378469 0.4242784127130607 0.0 1803 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +650093 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0104908896893283 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0016171311116606 0.2879885658616873 0.0 0.000755857898715 0.0278545700937657 0.0 1323 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +650118 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0104905914307798 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0561415215593491 0.0064028969591119 0.0 0.0003756830601092 0.0444552076275699 0.0 4880 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +650139 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0104903749375903 0.7487535481622718 0.8622452992050237 0.6198216015396206 0.0131092554497256 0.0254056950469408 0.0 0.0007507507507507 0.1179658853409051 0.0 1332 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +650199 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0104895905384548 0.6213271600240247 0.62431395375366 0.7917001487310438 0.2247035641022029 0.0019304335593669 0.0 0.0036713922210105 0.9064405716731224 0.0 917 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +650263 CCN1 CAV1 CCN1-CAV1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0104889327955012 0.7324582304061453 0.7283139964676212 0.8293805866303694 0.0025580826958339 0.1176565474247238 0.0 0.0018518518518518 0.12720314250006 0.0 324 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +650422 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0104868246182453 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0186793449598515 0.0244129856070659 0.0 0.0 0.0 0.0 233 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +650822 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0104822319780084 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0053032910137447 0.1370986982961073 0.0 0.000467872738615 0.0150724313970949 0.0 6412 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +651130 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0104785100788503 0.6593525851613742 0.6593689120110077 0.9592803095773328 0.0120646829101097 0.026308073552735 0.0 0.001806684733514 0.1316782637363562 0.0 1476 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +651339 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0104757201222705 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0025256125075084 0.1886404570313 0.0 0.0004099173553719 0.0107206636421147 0.0 6875 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +651586 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0104724491682688 0.4636527906642655 0.6593689120110077 0.2461374514707439 0.0666348171285698 0.026308073552735 0.0 0.0035746201966041 0.260532328786678 0.0 373 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +651750 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0104704793933819 0.6160088550075702 0.6632137581773894 0.9161861017439124 0.0548063857429699 0.0064230792457803 0.0 0.0006913238852402 0.0929828566114594 0.0 526 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +651875 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0104689536265686 0.4636527906642655 0.4630488285702799 0.2461374514707439 0.0693389464442948 0.0359289752254096 0.0 0.0009851645804357 0.2485062597170389 0.0 5752 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +651910 C1QB LRP1 C1QB-LRP1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0104684810332352 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.0419710388788557 0.0064028969591119 0.0 0.0002659574468085 0.0273407727466908 0.0 1880 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +652099 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells B Cells Plasma Cells -> B Cells 0.0104664966170981 0.8730912658940219 0.9546923450729716 0.6198216015396206 0.0057086106530109 0.0445745465878424 0.0 0.0064935064935064 0.2404881090665053 0.0 315 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +652367 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0104632899608113 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0255753403203798 0.0292373734098458 0.0 0.0008891734243846 0.1357818489722115 0.0 1278 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +652503 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0104613406383122 0.7160288858520609 0.4638256179742202 0.8293805866303694 0.0069047442087267 0.0689186266365139 0.0 0.0003473669584549 0.0326676354586937 0.0 7197 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +652614 VWF ITGA9 VWF-ITGA9 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0104599730533531 0.6332974881236617 0.8794572885381431 0.6198216015396206 0.0036144684673052 0.104965956217838 0.0 0.0004755488626456 0.0106581705706168 0.0 3441 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +652856 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0104569523946081 0.8640667164982425 0.7841656220878274 0.7827641335561659 0.1882781599600688 0.001309307002134 0.0 0.0001977848101265 0.0244282456715816 0.0 316 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +652865 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0104568764196654 0.6630837220165452 0.7461459456652184 0.6198216015396206 0.4103175828613323 0.0010390313650636 0.0 0.0104895104895104 0.9980458855033654 0.0 143 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +652894 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0104564822216077 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.000393370777602 1.0 0.0 0.00259009009009 0.0371895787566127 0.0 370 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +652909 C3 LRP1 C3-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0104563488132344 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0064915662046245 0.0587195251380622 0.0 7.079793436615027e-05 0.017086557078406 0.0 6003 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +653147 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.010453278045354 0.6342079770588467 0.6571792026963191 0.8824495942126559 0.002196330917593 0.1615138601457002 0.0 0.0001720578114246 0.0164457628927212 0.0 5812 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +653404 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0104502717645114 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0110717612136884 0.040323117011325 0.0 7.634753397465261e-05 0.005310370004393 0.0 2183 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +653589 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0104483182957879 0.4648000335061383 0.9078204025796472 0.2461374514707439 0.0357762282281787 0.0350138403862125 0.0 0.0037442396313364 0.218629262725386 0.0 1736 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +653651 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0104475496447462 0.7324582304061453 0.62431395375366 0.6198216015396206 0.2376713873232418 0.0019304335593669 0.0 0.0024534686971235 0.6057439343243539 0.0 394 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +653695 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0104470538627123 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0003521782369754 1.0 0.0 0.0048577376821651 0.0542414610699833 0.0 262 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +653741 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0104465733456994 0.8284725546778968 0.930308383061206 0.8567148457705164 0.0012187708721425 0.1615013370958009 0.0 0.002561475409836 0.0967078895047777 0.0 244 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +653831 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0104454643950472 0.7482742921073442 0.7779918296243433 0.6198216015396206 0.005733874009046 0.0627790816848129 0.0 0.0017647058823529 0.0387025230822655 0.0 170 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +653893 VWF LRP1 VWF-LRP1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.010444621016475 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.1263644540569636 0.0028784826949613 0.0 0.0027695294655093 0.28070172943806 0.0 398 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +653980 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0104437263315795 0.7158082793127664 0.7346293219749174 0.8293805866303694 0.0071496754272206 0.0416128058995347 0.0 0.000558716901473 0.0231657554785525 0.0 9905 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +653995 CD34 SELP CD34-SELP CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0104436171569743 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.1173076386135379 0.0032078747392388 0.0 0.0002742731760833 0.062790643857387 0.0 3646 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +654008 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0104435157603484 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0161757332769496 0.0446401662952339 0.0 0.0008262511803588 0.0932409947828023 0.0 1412 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +654145 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0104417513413123 0.8911088195487638 0.9078204025796472 0.9429656149619918 0.0048525806497539 0.0350138403862125 0.0 0.0010099440646364 0.0887200729570138 0.0 3218 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +654257 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0104401541779418 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0149256517769723 0.0293031867940321 0.0 0.0046490622177355 0.5818322392632121 0.0 1711 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +654590 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.010436105827973 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0015572459193676 0.2898144908728011 0.0 0.0006366182836771 0.0147853572231171 0.0 714 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +654703 VWF SELP VWF-SELP Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0104347966646879 0.9275752708651288 0.4623922682986163 0.2461374514707439 0.1263644540569636 0.0096770075292062 0.0 0.0014524501166722 0.4143560092489698 0.0 1909 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +654767 VWF ITGA9 VWF-ITGA9 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0104340309080281 0.6332974881236617 0.6252253442669611 0.8693461273411047 0.0019871862905238 0.1886404570313 0.0 0.0002920774005111 0.0076387679792241 0.0 1245 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +654825 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0104334484168897 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0149256517769723 0.0267210109213584 0.0 0.0030444333114956 0.3198901209690654 0.0 2359 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +654989 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0104315133478185 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0151307911035231 0.0289462771086338 0.0 0.0001962708537782 0.040587486553988 0.0 5095 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +655032 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0104309625302038 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0113788029360913 0.0326667674102811 0.0 0.0049686192468619 0.1051800312849279 0.0 239 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +655487 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0104251264806403 0.7487535481622718 0.7754239189773715 0.9429656149619918 0.0131092554497256 0.0178869147172998 0.0 0.0006541429050654 0.1118266711374556 0.0 2710 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +655488 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0104251184760451 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0015572459193676 0.2879885658616873 0.0 0.0017371163867979 0.0640155116978321 0.0 157 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +656337 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0104142376680852 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0131302879503246 0.0309945332907452 0.0 0.0001099263493459 0.0068570826626241 0.0 827 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +656384 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0104136213929827 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0683610513379333 0.0104714078116759 0.0 0.0018171190403578 0.1518874763046632 0.0 1093 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +656431 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0104129521634057 0.4648000335061383 0.6207977546603366 0.2461374514707439 0.0357762282281787 0.0501711964086628 0.0 0.0057886290692342 0.1555864809223033 0.0 727 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +656519 C3 LRP1 C3-LRP1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0104119275516626 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0064915662046245 0.0416128058995347 0.0 0.000481125092524 0.0449373895951435 0.0 2702 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +656644 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0104102602078398 0.6303642896310324 0.6331674633943454 1.0 0.0097699360831605 0.0326412663903893 0.0 4.1832265007694014e-05 0.0169494046417454 0.0 423716 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +656972 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0104059473317229 0.2490567623945399 0.7746834992804791 0.2461374514707439 0.011649387573427 0.2295016807597237 0.0 0.0014781966001478 0.0734820905572057 0.0 902 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +656984 A2M LRP1 A2M-LRP1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0104057012458993 0.7741139100414175 0.6207977546603366 0.8693461273411047 0.0149044683666724 0.0203874717835032 0.0 0.0018091361374943 0.1072709811367327 0.0 737 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +657110 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0104041251004134 0.633566764858408 0.6572093097629401 0.8824495942126559 0.0083565457974945 0.04130664769978 0.0 0.0002892322948516 0.1103825140150383 0.0 12101 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +657311 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0104014519851641 0.8023917560710954 0.4596166826058663 0.8293805866303694 0.0085367158000785 0.0484993884807927 0.0 0.0066417600664176 0.0944224506501462 0.0 219 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +657525 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0103987846146722 0.6249837837987587 0.6580560501976399 1.0 0.0084812136822336 0.0362497659817488 0.0 0.0021668472372697 0.073901441176609 0.0 1846 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +657859 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0103947859170987 0.6342079770588467 0.8818120773736414 0.6198216015396206 0.0673400749834054 0.0054043611446182 0.0 0.0 0.0 0.0 1351 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +657974 VWF ITGA9 VWF-ITGA9 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0103932916161373 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0036144684673052 0.1112417752963437 0.0 0.0001560671088568 0.0168698473099533 0.0 1165 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +658021 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0103925748472438 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0637288077574987 0.0064230792457803 0.0 0.0 0.0 0.0 398 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +658071 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0103920178603118 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.2545335314555431 0.0026174949623928 0.0 0.0039453717754172 0.5352514029733 0.0 659 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +658397 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0103877554215959 0.7835752212271604 0.6580560501976399 0.6198216015396206 0.0064863313435223 0.0606066271159369 0.0 0.0027777777777777 0.0666008140201575 0.0 30 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +658484 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0103865611479427 0.2490567623945399 0.8818326005152037 0.2461374514707439 0.011649387573427 0.1993723722552783 0.0 0.0011997046880767 0.0444481293813254 0.0 1806 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +658585 THBS2 CD36 THBS2-CD36 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0103853085652928 0.724503440376099 0.8587566561291643 0.7204611100467462 0.0009736808737186 0.287457858136305 0.0 0.0025811209439528 0.0785009722654462 0.0 452 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +658646 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0103846237493991 0.8498991475190484 0.9078204025796472 0.6198216015396206 0.018166235813628 0.0144359394371152 0.0 0.0003693853427895 0.0345185887140682 0.0 1692 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +658742 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0103834208751321 0.6582846571368821 0.6587114738285964 0.9161861017439124 0.4344545964241579 0.0007261054236978 0.0 0.0013043478260869 0.200316394743064 0.0 460 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +658913 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0103812608153856 0.9356727248601746 0.8341464445360613 0.8567148457705164 1.0 0.0001871866311057 0.0 0.0007407407407407 0.0940386230058775 0.0 225 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +659498 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.010373465811123 0.6589792304505506 0.6207977546603366 0.9161861017439124 0.1836996873148393 0.0018097844702233 0.0 0.0050724637681159 0.4512783637439989 0.0 460 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +659508 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0103732682068755 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.1357656553382984 0.0026482500471321 0.0 0.000331409856519 0.1236659235919476 0.0 6412 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +659906 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0103683540575862 0.8023917560710954 0.8628183098412396 0.6198216015396206 0.0085367158000785 0.0339152418223636 0.0 0.0017123966942148 0.1308310596744851 0.0 6875 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +659919 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0103682337873974 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0055862851962672 0.0455125113141721 0.0 0.0003383207128303 0.0769298292600381 0.0 10961 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +659955 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0103677871128782 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0106922602624424 0.0326412663903893 0.0 7.918352982579625e-05 0.0320832182463055 0.0 5683 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +659976 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0103676090884285 0.6342079770588467 0.6580560501976399 0.9592803095773328 0.0085570823799139 0.0362497659817488 0.0 0.0035674470457079 0.1496164868339912 0.0 1495 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +660076 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0103664558075851 0.6605327397359113 0.4642836810638544 0.2461374514707439 0.0179229861158654 0.0917308979735958 0.0 0.0 0.0 0.0 19 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +660203 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0103647404105194 0.6342079770588467 0.7480927101953669 0.6198216015396206 0.0673400749834054 0.006260692484444 0.0 0.0 0.0 0.0 756 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +660263 CD34 SELP CD34-SELP CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.010363998586508 0.7168245244832976 0.7478729882108823 0.7204611100467462 0.1173076386135379 0.0027351735586246 0.0 0.0007570022710068 0.2213815939198786 0.0 1321 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +660327 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0103633161802534 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0048313935743179 0.0627790816848129 0.0 0.0006835269993164 0.0137249486653407 0.0 209 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +660642 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.010359542305428 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0149256517769723 0.0279580382843415 0.0 0.0014913459922702 0.2091293493776136 0.0 2164 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +660684 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0103589605380459 0.6561647292424944 0.2550748532138862 0.2461374514707439 0.112230917768503 0.0267255153180908 0.0 0.0002264492753623 0.0196982365886129 0.0 184 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +660784 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0103576729624692 0.6303642896310324 0.9015117569158254 0.6198216015396206 0.0141923232885854 0.0246995741084876 0.0 0.0017654751525719 0.0898610272651354 0.0 3441 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +660968 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0103556062200272 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0415873844357376 0.0155837683010033 0.0 0.0004076456200742 0.0960546232710896 0.0 1577 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +661139 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0103534378423661 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0515877972474039 0.0064028969591119 0.0 0.0001024590163934 0.0105329206483153 0.0 4880 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +661223 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.010352328591375 0.7745997874735252 0.777821334064334 0.8693461273411047 0.0215813276111062 0.0108892901157311 0.0 0.0004789272030651 0.0594296787670808 0.0 1044 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +661462 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0103491742314244 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.1027229557481577 0.0038860320327025 0.0 0.0004370629370629 0.2472373908930646 0.0 312 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +661464 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0103491669045426 0.9184503888425788 0.8341464445360613 0.8567148457705164 1.0 0.0001871866311057 0.0 0.0022222222222222 0.6869901245169604 0.0 225 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +661896 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0103440243979655 0.7800321422220979 0.9015117569158254 0.6198216015396206 0.0113788029360913 0.0246995741084876 0.0 0.0008037354562155 0.0774425024242172 0.0 1633 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +661992 C3 LRP1 C3-LRP1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0103429101425579 0.9487258305485792 0.9078204025796472 0.8875000050982297 0.0110943464444434 0.0144359394371152 0.0 0.0006451612903225 0.1101772227775949 0.0 2790 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +662000 CD48 CD2 CD48-CD2 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0103427359152659 0.9426443637490616 0.4603649459881741 0.6198216015396206 0.0632786830726401 0.0071918009517169 0.0 0.002016129032258 0.4927676424500166 0.0 496 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +662200 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0103400211685037 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0069047442087267 0.0606066271159369 0.0 0.0017703591299949 0.0501265768100005 0.0 659 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +662320 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0103384545053742 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.1027229557481577 0.0038621268649178 0.0 0.0013401831583649 0.8283918261840062 0.0 407 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +662422 CD34 SELP CD34-SELP CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0103372584569625 0.7168245244832976 0.941479368642921 0.7204611100467462 0.1173076386135379 0.0021392900294222 0.0 0.0003984063745019 0.1288769259716964 0.0 10040 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +662533 COL4A1 CD93 COL4A1-CD93 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0103357991319681 0.8684504425765611 0.7779918296243433 0.909150863993142 0.0168149984327668 0.0118035014556376 0.0 0.0006393707626607 0.0606663838660533 0.0 5921 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +662675 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0103340577525986 0.7941469661104034 0.4614667734221426 0.2461374514707439 0.0083898580598364 0.1609352200462838 0.0 0.0047619047619047 0.1000379985216929 0.0 155 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +662846 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0103321041498299 0.4625081978296446 0.8381155706134242 0.7204611100467462 0.149715856631667 0.0029095741067474 0.0 0.0015403573629081 0.0486536298705351 0.0 1082 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +662863 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0103318981913531 0.2534163760166434 0.4638256179742202 0.3990376746076917 0.0050543892975134 0.5131068416842878 0.0 0.0037453183520599 0.090461455165916 0.0 89 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +663009 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0103302304714357 0.8978557803479422 0.657421674383923 0.6198216015396206 0.0477973731763516 0.0069492509109592 0.0 0.0006154603643525 0.1053215928249291 0.0 1354 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +663088 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0103293850271438 0.6213271600240247 0.62431395375366 0.7917001487310438 0.1153131738111426 0.0034299077593249 0.0 0.0014330753797649 0.1482491772170665 0.0 1163 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +663121 VWF ITGA9 VWF-ITGA9 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0103290088150152 0.9011206516381156 0.7292496872084557 0.7204611100467462 0.0008850282134344 0.2898144908728011 0.0 0.0007628734901462 0.0177176140821912 0.0 715 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +663296 A2M LRP1 A2M-LRP1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0103269703133585 0.7741139100414175 0.2550748532138862 0.2461374514707439 0.093381536992618 0.0267255153180908 0.0 0.0063164893617021 0.5494550673972662 0.0 752 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +663315 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.010326653777538 0.6213271600240247 0.62431395375366 0.9161861017439124 0.0052560850129547 0.0649213179279442 0.0 0.0008169934640522 0.0336611985619461 0.0 408 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +663430 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0103253561461054 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.0673400749834054 0.0046263543438723 0.0 0.0 0.0 0.0 827 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +663442 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0103251702578406 0.6659645551150886 0.6614977577544194 0.8824495942126559 0.0137371823984124 0.0226890201466244 0.0 0.0003718700933807 0.0538988828136487 0.0 12101 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +663632 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0103227416330732 0.6561647292424944 0.2550748532138862 0.2461374514707439 0.1098969873322313 0.0267255153180908 0.0 0.0032258064516129 0.2806045573397244 0.0 155 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +663996 VWF ITGA9 VWF-ITGA9 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0103181342170773 0.9011206516381156 0.7292496872084557 0.7204611100467462 0.0008850282134344 0.2879885658616873 0.0 0.0003355266836915 0.012364693873151 0.0 9754 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +664289 VEGFC FLT1 VEGFC-FLT1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0103146242944828 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0012459853895406 0.2390217618875283 0.0 0.0 0.0 0.0 797 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +664303 CD34 SELP CD34-SELP CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0103144115260823 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0298399317533219 0.0222228052993653 0.0 0.000755857898715 0.2019754158615029 0.0 1323 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +664426 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0103129026777356 0.9275752708651288 0.7346293219749174 0.7204611100467462 0.000245041593909 1.0 0.0 0.0003016894609814 0.0023162240415128 0.0 10961 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +664521 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0103119269892928 0.7158082793127664 0.8794572885381431 0.7204611100467462 0.0025256125075084 0.104965956217838 0.0 0.0006152899553914 0.0137900977377299 0.0 591 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +665209 CD48 CD2 CD48-CD2 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0103029135502132 0.9426443637490616 0.6614977577544194 0.7917001487310438 0.0632786830726401 0.0038288178384739 0.0 0.0 0.0 0.0 50 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +665540 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0102986467919452 0.4636527906642655 0.7472387841445823 0.7204611100467462 0.0693389464442948 0.0068935067166085 0.0 0.0013878374968458 0.0843888932798073 0.0 1321 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +665638 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0102974300868471 0.6630837220165452 0.6587114738285964 0.9161861017439124 0.4103175828613323 0.0007261054236978 0.0 0.0021739130434782 0.2906811842036423 0.0 460 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +665735 CD48 CD2 CD48-CD2 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0102964099053597 0.4593282471594782 0.937587088419394 0.6198216015396206 0.0161888123016941 0.0275738893167071 0.0 0.0050761421319796 0.2117174522484518 0.0 394 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +665771 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0102960408582671 0.6659645551150886 0.4603649459881741 0.2461374514707439 0.1496557267835524 0.0105486447632276 0.0 0.0 0.0 0.0 184 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +665873 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0102946798148078 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.0120646829101097 0.0521374123931907 0.0 0.0 0.0 0.0 77 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +666712 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0102846351962209 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0072827533047186 0.0501711964086628 0.0 0.0037214247740563 0.0631418187736757 0.0 209 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +666807 CD48 CD2 CD48-CD2 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0102834646785519 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0164675938709007 0.0226890201466244 0.0 0.0 0.0 0.0 6003 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +667003 COL4A1 CD93 COL4A1-CD93 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0102812094613174 0.9102252263107924 0.7779918296243433 0.6198216015396206 0.0042860632265532 0.0627790816848129 0.0 0.0004234058768735 0.0085018206018263 0.0 1687 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +667051 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0102805484126252 0.6561647292424944 0.6207977546603366 0.9161861017439124 0.1098969873322313 0.0028784826949613 0.0 0.0033269961977186 0.5377900676295092 0.0 526 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +667059 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0102804243204944 0.2451358214448441 0.663300745568453 0.2461374514707439 0.1327555461750915 0.0222186841038061 0.0 0.014415289925494 0.5700238789724528 0.0 147 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +667301 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0102773655830201 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0004094805141934 1.0 0.0 0.0003246753246753 0.0057516912536429 0.0 77 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +667886 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Macrophages B Cells -> Macrophages 0.0102701475062673 0.7797302331085993 0.9130058539314824 0.6198216015396206 0.0200499113739789 0.0132636308162813 0.0 0.0014084507042253 0.182840279337198 0.0 1065 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +668200 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0102663760516851 0.6303682835571691 0.4614667734221426 0.2461374514707439 0.0101610580570933 0.1609352200462838 0.0 0.00241323928737 0.0506972819351068 0.0 5752 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +668250 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0102659011423832 0.7835752212271604 0.4638256179742202 0.7204611100467462 0.0064863313435223 0.0689186266365139 0.0 0.0006400409626216 0.0779875765368091 0.0 1302 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +668352 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0102647480353044 0.4604235282221027 0.7461459456652184 0.7204611100467462 0.454846709299195 0.0010390313650636 0.0 0.0023791499945928 0.2263690822820798 0.0 1321 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +668607 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0102618490786391 0.4604235282221027 0.4630027772793905 0.2461374514707439 0.454846709299195 0.0048929293424311 0.0 0.0008444267832306 0.2272293886819324 0.0 5752 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +668919 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.01025819912855 0.7840818683779507 0.4641352222874551 0.7204611100467462 0.0032417203409647 0.1370986982961073 0.0 0.0 0.0 0.0 85 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +669081 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0102561533766192 0.7741139100414175 0.6207977546603366 0.8693461273411047 0.1671376945154473 0.0016667952436519 0.0 0.0012345679012345 0.2479106911888526 0.0 270 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +669179 COL4A1 CD93 COL4A1-CD93 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0102548434531494 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.4857192596400828 0.0009242223287825 0.0 0.0014503263234227 0.2797661726171073 0.0 394 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +669267 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0102539577453082 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0024635726452692 0.1341680150528327 0.0 0.001759014951627 0.0438019780316557 0.0 379 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +669379 VWF LRP1 VWF-LRP1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0102525266075176 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0025256125075084 0.166956519448744 0.0 0.0007347805843324 0.0055363971322321 0.0 1562 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +669392 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0102523109972966 0.6561647292424944 0.6207977546603366 0.8824495942126559 0.112230917768503 0.0028784826949613 0.0 0.0004952428782679 0.0800532026995884 0.0 11947 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +669745 CCN1 CAV1 CCN1-CAV1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0102473368176265 0.8619922139338987 0.62431395375366 0.6198216015396206 0.0054092055025683 0.0641739251983978 0.0 0.0005611672278338 0.0533081785620245 0.0 594 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +669954 CXCL12 ITGA4 CXCL12-ITGA4 B Cells B Cells B Cells -> B Cells 0.0102450859511791 0.6160088550075702 0.9460955677032749 1.0 0.0052742025956585 0.0376195773145198 0.0 0.0038466470060264 0.139955705633494 0.0 1418 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +669957 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0102450446210137 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0071496754272206 0.0587195251380622 0.0 9.359920128681568e-05 0.0097340152928226 0.0 3278 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +669992 COL4A2 CD93 COL4A2-CD93 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0102446979702371 0.7783550150988336 0.7779918296243433 0.909150863993142 0.0033449520260795 0.0627790816848129 0.0 0.0007746933505487 0.0169901327927311 0.0 1549 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +670154 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Pericytes Macrophages -> Pericytes 0.0102426580896495 0.8949858186325867 0.896164124004365 0.8875000050982297 0.001895566065636 0.0855781119790033 0.0 0.0012126111560226 0.0611034076122205 0.0 2474 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +670534 CCN1 CAV1 CCN1-CAV1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0102382411880539 0.8619922139338987 0.62431395375366 0.6198216015396206 0.0054092055025683 0.0638329144736252 0.0 9.584052137243628e-05 0.0250199687280591 0.0 1739 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +670924 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0102334061092146 0.6213271600240247 0.62431395375366 0.8824495942126559 0.0052560850129547 0.0638329144736252 0.0 0.0003005238489109 0.0784542612468543 0.0 12090 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +671267 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Macrophages Pericytes -> Macrophages 0.0102290820475388 0.9468422434493456 0.9195415044619336 0.8875000050982297 0.1120119983652299 0.0013235329769289 0.0 0.0010980392156862 0.296154209681927 0.0 2125 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +671683 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.010223772974199 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0799339500711946 0.0036702914086929 0.0 0.0001480263157894 0.0605400122192232 0.0 30400 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +671869 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0102215500354585 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.0070489045197697 0.0501711964086628 0.0 0.0062607944732297 0.1682773188983184 0.0 193 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +672429 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0102149086402083 0.6160088550075702 0.8622452992050237 0.7917001487310438 0.0106340017102282 0.0254056950469408 0.0 0.0001599880382775 0.0251390099317092 0.0 30400 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +672469 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0102143917729331 0.7745997874735252 0.777821334064334 0.909150863993142 0.0065101973396288 0.0318483483218543 0.0 0.0005066711704104 0.0641199811947113 0.0 5921 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +672680 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0102122390240862 0.633566764858408 0.7760344326192508 0.8693461273411047 0.0078992851324392 0.0335947364052305 0.0 0.0 0.0 0.0 575 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +672796 MMRN2 CD93 MMRN2-CD93 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0102109295468462 0.9468422434493456 0.6587114738285964 0.6198216015396206 0.1120119983652299 0.0026174949623928 0.0 0.0031407035175879 1.0 0.0 398 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +673049 A2M LRP1 A2M-LRP1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0102077363345123 0.8937519114898692 0.7769451595923457 0.7827641335561659 0.3743986430148447 0.0005558995075445 0.0 0.0030327004219409 0.5735595503171608 0.0 316 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +673569 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.01020126708815 0.6605327397359113 0.9130058539314824 0.6198216015396206 0.0227314494836465 0.0132636308162813 0.0 0.0007347538574577 0.0953832463845779 0.0 1361 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +673738 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0101992072143235 0.7324582304061453 0.8617632615906476 0.7204611100467462 0.2376713873232418 0.0010414441948928 0.0 0.0 0.0 0.0 38 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +673830 CD48 CD2 CD48-CD2 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0101980911728499 0.928447473463448 0.7763428264267787 0.6198216015396206 1.0 0.0002517784065132 0.0 0.0029255319148936 1.0 0.0 1880 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +674117 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0101943706798172 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0071496754272206 0.0565946652887153 0.0 0.0002173558658914 0.0080400524095946 0.0 1673 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +674244 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0101927302884388 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.0047694898966413 0.0627790816848129 0.0 0.0008052826542116 0.0161697535008805 0.0 887 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +674245 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0101927277477837 0.8023917560710954 0.7754239189773715 0.7204611100467462 0.0085367158000785 0.0293031867940321 0.0 0.0005178663904712 0.0648112129920716 0.0 1931 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +674651 COL4A1 CD93 COL4A1-CD93 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0101881286079854 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.4857192596400828 0.0007261054236978 0.0 0.002273588480485 0.3040091202736085 0.0 377 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +674739 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0101867681195655 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0255753403203798 0.0147571931436988 0.0 0.0085995085995085 0.1722142243366357 0.0 333 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +674878 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0101851091414588 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0075637985935472 0.0416128058995347 0.0 0.0018098835379288 0.0597638290336588 0.0 1412 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +674897 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0101848117813946 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0012306151710811 0.1993723722552783 0.0 0.001865671641791 0.0691216891469635 0.0 536 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +674898 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0101848105557378 0.8949858186325867 0.6571792026963191 0.6198216015396206 0.001895566065636 0.1615138601457002 0.0 0.0005750431282346 0.0549642173274848 0.0 1739 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +674929 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.010184467992398 0.6589792304505506 0.8604147465201248 0.6198216015396206 0.0072827533047186 0.0436001007095475 0.0 0.0014832793959007 0.034086817142666 0.0 103 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +675166 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0101813968006253 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0215813276111062 0.0232163927704059 0.0 0.0003379080889997 0.0661171091325486 0.0 6412 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +675540 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0101770169338356 0.8730912658940219 0.4596166826058663 1.0 0.0057086106530109 0.0484993884807927 0.0 0.0167041439126244 0.2374741316262953 0.0 283 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +675599 CD48 CD2 CD48-CD2 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0101763175470704 0.6659645551150886 0.937587088419394 0.7917001487310438 0.0081474500750471 0.0275738893167071 0.0 0.0021810250817884 0.0909669315004253 0.0 917 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +675781 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0101739052963234 0.8937519114898692 0.8604147465201248 0.8875000050982297 0.0037268694422441 0.0436001007095475 0.0 0.0014922752808988 0.0427500336665621 0.0 1424 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +675826 CD48 CD2 CD48-CD2 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0101734092141675 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0112468593062777 0.0229905310518441 0.0 0.0030864197530864 0.1455156033250078 0.0 162 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +676056 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0101706793746422 0.724503440376099 0.8587566561291643 0.7204611100467462 0.0027791828709671 0.088850508457521 0.0 0.0 0.0 0.0 591 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +676469 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0101655839710746 0.255669001367946 0.9008184599638702 0.2461374514707439 0.0061207051981986 0.3180524283074206 0.0 0.0041265474552957 0.0573450373706456 0.0 727 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +676544 COL4A2 CD93 COL4A2-CD93 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0101643846572398 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0316800311254893 0.0155837683010033 0.0 0.0003125287250666 0.0863973090016284 0.0 10879 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +676887 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0101603350791425 0.8023917560710954 0.6631822525600675 0.6198216015396206 0.0085367158000785 0.0390724515618796 0.0 0.0001962708537782 0.1108967880571979 0.0 5095 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +677023 CD34 SELP CD34-SELP Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0101588469557195 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0042829523358709 0.0741032966028748 0.0 0.0014611338398597 0.073461473818065 0.0 1711 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +677394 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0101546526495358 0.7783550150988336 0.7779918296243433 0.8693461273411047 0.1928969878996252 0.001079730675535 0.0 0.0018518518518518 0.3131765579380332 0.0 270 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +677721 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.010150916714229 0.8667347161816407 0.6614977577544194 0.7917001487310438 0.0106228227237899 0.0226890201466244 0.0 0.0001323758149386 0.0191865618229021 0.0 30217 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +677873 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0101489738754775 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0083565457974945 0.0335947364052305 0.0 0.0120481927710843 1.0 0.0 83 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +678007 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Pericytes B Cells -> Pericytes 0.0101473068297352 0.7797302331085993 0.885766439573873 0.6198216015396206 0.0200499113739789 0.0127192475389894 0.0 0.0017891549683457 0.2698484690547122 0.0 1211 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +678028 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Macrophages Pericytes -> Macrophages 0.010147082476294 0.6303682835571691 0.773263018678637 0.8875000050982297 0.0342558468646473 0.0073658308476012 0.0 0.0038431372549019 0.6997373098228497 0.0 2125 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +678113 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Macrophages Macrophages -> Macrophages 0.0101457474038375 0.8913986641324685 0.9015117569158254 1.0 0.0054950348959687 0.0246995741084876 0.0 0.000330553295362 0.0318498757015712 0.0 2458 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +678150 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0101452783549068 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.454846709299195 0.001079730675535 0.0 0.00072576289495 0.1117132180028209 0.0 4232 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +678270 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0101439840384268 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0587727051993296 0.0104714078116759 0.0 0.0011633919338159 0.1163575580929329 0.0 11604 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +678488 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Pericytes Pericytes -> Pericytes 0.0101414421987545 0.8721681415062816 0.885766439573873 1.0 0.0110717612136884 0.0127192475389894 0.0 0.0002664535038635 0.0401877262528754 0.0 12510 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +678547 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0101407455287171 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0024635726452692 0.1281708518900828 0.0 0.0026385224274406 0.0544932079722261 0.0 379 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +678687 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0101390017004933 0.6249837837987587 0.8923034233058523 0.6198216015396206 0.1661175896787547 0.00189193058407 0.0 0.001578947368421 0.5958074516266587 0.0 475 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +678899 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0101361912126127 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0003083910058032 1.0 0.0 0.002650762094102 0.0167450362453279 0.0 1509 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +679197 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0101326432627895 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.112230917768503 0.0032275631628407 0.0 0.0012135922330097 0.0716699681851374 0.0 103 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +679315 A2M LRP1 A2M-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.010131074641531 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2100317344087863 0.0028784826949613 0.0 0.0055007587253414 0.8891664525927303 0.0 659 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +679717 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0101261646996362 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0131092554497256 0.0267210109213584 0.0 0.0004155478839023 0.0436631876113083 0.0 1422 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +679914 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0101236683153701 0.4636527906642655 0.777821334064334 0.2461374514707439 0.0666348171285698 0.0182001711419816 0.0 0.0001847745750184 0.0221309071438607 0.0 902 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +680039 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0101222611857084 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0078992851324392 0.04130664769978 0.0 0.0001654697686732 0.0631498258830638 0.0 30217 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +680058 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0101219972495547 0.6561647292424944 0.8604147465201248 0.6198216015396206 0.0070489045197697 0.0436001007095475 0.0 0.0031512605042016 0.0902758990724436 0.0 119 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +680086 C1QB LRP1 C1QB-LRP1 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.0101217777853226 0.7753420160918723 0.9078204025796472 0.946515890536252 0.0111808254589153 0.0144359394371152 0.0 0.0002821925230269 0.0263705310205 0.0 11074 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +680095 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0101216817257841 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0085570823799139 0.0689186266365139 0.0 0.0053078556263269 0.4991697927732885 0.0 157 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +680129 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0101212807964325 0.7941469661104034 0.663300745568453 0.9161861017439124 0.0083898580598364 0.0265498740402422 0.0 0.0052277432712215 0.1328107630910292 0.0 460 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +680269 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0101197263446983 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0104129581710415 0.0326412663903893 0.0 0.000225866234239 0.0915154414498002 0.0 30217 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +680761 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0101140263363133 0.8023917560710954 0.7757991160529997 0.7204611100467462 0.0085367158000785 0.0279580382843415 0.0 0.0007282437188979 0.102120591674117 0.0 2247 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +681166 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0101088112474887 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.3309594876493178 0.0018097844702233 0.0 0.0046296296296296 0.4118810462742849 0.0 135 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +681465 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0101054794533148 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.1194227711616854 0.0049190726392343 0.0 0.0011371691871455 0.2299466065924656 0.0 4232 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +681529 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0101044836330947 0.6342079770588467 0.4638256179742202 0.2461374514707439 0.0028649117803088 0.5131068416842878 0.0 0.0019946808510638 0.0453135873045516 0.0 752 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +681549 CD48 CD2 CD48-CD2 B Cells Plasma Cells B Cells -> Plasma Cells 0.0101042203807809 0.9426443637490616 0.4603649459881741 0.6198216015396206 0.0632786830726401 0.0062523288579129 0.0 0.0033670033670033 0.0397955215429782 0.0 297 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +681559 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0101041575934396 0.4619393085577573 0.6331674633943454 0.2461374514707439 0.0835287751665837 0.0176963220730796 0.0 0.0005933544303797 0.1084678590774548 0.0 316 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +681785 A2M LRP1 A2M-LRP1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0101013519441806 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.093381536992618 0.0032275631628407 0.0 0.0031380753138075 0.1853223445121963 0.0 239 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +681821 MMRN2 CD93 MMRN2-CD93 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0101009706588682 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0003083910058032 1.0 0.0 0.0046388336646785 0.0276581510167733 0.0 1509 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +681850 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.010100750249169 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0053032910137447 0.0606066271159369 0.0 0.001171875 0.0331808847165305 0.0 1280 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +682050 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0100980472392405 0.4625081978296446 0.657421674383923 0.6198216015396206 0.0141498126994191 0.0397596998227057 0.0 0.0 0.0 0.0 3 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +682115 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0100972156499408 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.1098969873322313 0.0032275631628407 0.0 0.0064229249011857 0.3793125984185732 0.0 253 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +682284 COL4A1 CD93 COL4A1-CD93 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0100954687890731 0.7766289238087107 0.8817184225858201 0.9429656149619918 0.4857192596400828 0.0003375370073613 0.0 0.0008188035834698 0.7134504263006138 0.0 2966 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +682551 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0100920975517593 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.7696906278989153 0.0007261054236978 0.0 0.0014814814814814 0.2275198557575543 0.0 135 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +682922 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0100874439484868 0.7296454584598743 0.4638256179742202 0.8767341187813953 0.0051524613572059 0.0689186266365139 0.0 0.0004761904761904 0.058022756943386 0.0 2450 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +682984 MMP2 PECAM1 MMP2-PECAM1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.010086675558541 0.9330801352629944 0.6331674633943454 0.6198216015396206 0.0088108219576754 0.0326412663903893 0.0 0.0001293847038527 0.0524234989343745 0.0 1739 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +683027 CD34 SELP CD34-SELP Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0100861561045896 0.9303167350027568 0.6572093097629401 0.6198216015396206 0.1314667522621683 0.002113171886167 0.0 0.0006331785563528 0.1833942724517192 0.0 2369 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +683079 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0100855287458844 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0020251995753771 0.166956519448744 0.0 0.0014546915323562 0.010960755087638 0.0 1867 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +683361 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.010082020306609 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0084812136822336 0.0689186266365139 0.0 0.0032467532467532 0.3956097064321774 0.0 77 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +683370 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0100818817030634 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0425206505665654 0.0069492509109592 0.0 5.546311702717693e-05 0.0094912104282831 0.0 3005 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +683422 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0100812796189105 0.8771078809726828 0.4638256179742202 0.7204611100467462 0.0080232294691882 0.0446401662952339 0.0 0.0 0.0 0.0 715 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +683424 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0100812543492833 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.141548283585814 0.0026482500471321 0.0 0.0008461995249406 0.7728370299823303 0.0 1684 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +683587 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.010079250286558 0.6605327397359113 0.885766439573873 0.6198216015396206 0.0227314494836465 0.0127192475389894 0.0 0.0002623638987275 0.0395709134532445 0.0 2541 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +683717 VEGFC FLT1 VEGFC-FLT1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.010077516531305 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.0023125636768155 0.2390217618875283 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +683902 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0100752310862006 0.4604235282221027 0.4630027772793905 1.0 0.0839650520556947 0.0058437228618857 0.0 0.000552620314706 0.1346948018283074 0.0 22361 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +684447 A2M LRP1 A2M-LRP1 Pericytes Mast Cells Pericytes -> Mast Cells 0.0100682799892521 0.8937519114898692 0.8755243548400705 0.8567148457705164 0.3743986430148447 0.0004150165744076 0.0 0.0035185185185185 0.5117845117845118 0.0 225 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +684539 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.010067155911534 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0070532058552773 0.0416128058995347 0.0 0.0014454007998608 0.0477283120586046 0.0 1278 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +684609 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0100663714372107 0.8771078809726828 0.6580560501976399 0.6198216015396206 0.0080232294691882 0.0362497659817488 0.0 0.0 0.0 0.0 129 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +684959 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Macrophages Pericytes -> Macrophages 0.0100620623132613 0.8721681415062816 0.9130058539314824 0.8875000050982297 0.0110717612136884 0.0132636308162813 0.0 0.0005490196078431 0.071271857906343 0.0 2125 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +685005 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0100614969817515 0.8978557803479422 0.657421674383923 0.6198216015396206 0.0477973731763516 0.0059327142047454 0.0 0.0 0.0 0.0 129 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +685036 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0100611351552868 0.940547666092272 0.9003264838243337 0.9429656149619918 0.0001298888146421 1.0 0.0 0.0008610086100861 0.0054390472896494 0.0 2710 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +685102 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0100603398034111 0.831981591331937 0.4642836810638544 0.7204611100467462 0.0048935684578858 0.0761275033764692 0.0 0.0020813320525136 0.2004524427400047 0.0 1041 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +685201 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0100589118151959 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0052560850129547 0.0641739251983978 0.0 0.0019376579612468 0.1840681555638701 0.0 1187 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +685312 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0100576450082147 0.6303642896310324 0.6331674633943454 0.909150863993142 0.0161193721503025 0.0176963220730796 0.0 0.001317345043067 0.1744804527134401 0.0 5921 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +685423 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0100560082650343 0.4636527906642655 0.777821334064334 0.6198216015396206 0.014525360548861 0.0318483483218543 0.0 0.0003049710277523 0.0385945317326304 0.0 1093 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +685602 VWF LRP1 VWF-LRP1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0100537281419687 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0019871862905238 0.166956519448744 0.0 0.0027554048325561 0.0207613207784497 0.0 2359 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +686589 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0100420450323591 0.831981591331937 0.885766439573873 0.8567148457705164 0.0048935684578858 0.0331922776397286 0.0 0.0030193236714975 0.3351796163172053 0.0 276 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +686745 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0100402222482052 0.6160088550075702 0.6631822525600675 0.8824495942126559 0.0106340017102282 0.0267210109213584 0.0 0.0002043556956851 0.0214724257439337 0.0 4671 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +686795 COL4A1 CD93 COL4A1-CD93 B Cells Pericytes B Cells -> Pericytes 0.0100394634641031 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0016831757123532 0.1281708518900828 0.0 0.0012386457473162 0.0291861038202078 0.0 1211 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +686805 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0100393464506878 0.6242573126045354 0.7763054211764489 0.6198216015396206 0.1932385901170197 0.0017638974017382 0.0 0.0075757575757575 1.0 0.0 143 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +686824 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.010039064314193 0.7160288858520609 0.4638256179742202 1.0 0.0069047442087267 0.0446401662952339 0.0 0.0003950330187976 0.0357498463851618 0.0 22361 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +686952 A2M LRP1 A2M-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0100374560857681 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.093381536992618 0.0028784826949613 0.0 0.0047425474254742 0.7666058958621187 0.0 246 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +687286 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0100335769855077 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0034559943126159 0.088850508457521 0.0 0.0001233654083395 0.0024093640485173 0.0 1351 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +687380 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0100325169932658 0.8730912658940219 0.6632137581773894 0.6198216015396206 0.0057086106530109 0.049767778498468 0.0 0.0003071253071253 0.1049586834234695 0.0 148 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +687382 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0100324868298129 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0110717612136884 0.0219439768073448 0.0 0.000501002004008 0.0687858230977132 0.0 1996 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +687859 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0100267531757168 0.4625081978296446 0.4642836810638544 0.8293805866303694 0.0141498126994191 0.040323117011325 0.0 0.0061728395061728 0.4293532488737039 0.0 324 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +687902 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0100261754012693 0.940547666092272 0.8817184225858201 0.9429656149619918 0.0001298888146421 1.0 0.0 0.0010147601476014 0.0060503116595601 0.0 2710 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +687930 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0100258130115602 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0003521782369754 1.0 0.0 0.0029515938606847 0.0226608932199955 0.0 77 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +687938 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0100257517857614 0.8624864526942296 0.4638256179742202 0.2461374514707439 0.0020100505037262 0.5131068416842878 0.0 0.0 0.0 0.0 41 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +688323 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0100213726056652 0.6342079770588467 0.7754072541855492 0.8693461273411047 0.0028649117803088 0.0826982152707935 0.0 0.0 0.0 0.0 1245 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +688398 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0100203377607696 0.8721681415062816 0.4642836810638544 0.2461374514707439 0.0110717612136884 0.0917308979735958 0.0 8.730574471800244e-05 0.0048040573098242 0.0 1909 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +688423 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0100200419308104 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0002165306714062 1.0 0.0 0.001865671641791 0.01178556888722 0.0 536 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +688485 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0100193922157868 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0131092554497256 0.0310998965832685 0.0 0.0009455009911172 0.1784284583650166 0.0 10961 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +688666 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0100173314632316 0.8533682807143209 0.4630027772793905 0.6198216015396206 0.0706049302656684 0.0058437228618857 0.0 0.0004567329115052 0.1113233577675837 0.0 6412 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +688695 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0100170193340413 0.7840818683779507 0.7754072541855492 0.6198216015396206 0.0032417203409647 0.0826982152707935 0.0 0.0 0.0 0.0 162 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +688859 VWF SELP VWF-SELP Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0100149066525719 0.9275752708651288 0.6572093097629401 0.6198216015396206 0.1263644540569636 0.002113171886167 0.0 0.0008826125330979 0.1766954828284921 0.0 2369 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +689100 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0100118557907036 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0020251995753771 0.1347191569099048 0.0 0.001008420309585 0.043708437300786 0.0 1803 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +689195 COL4A1 CD93 COL4A1-CD93 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0100109351193337 0.8684504425765611 0.7779918296243433 1.0 0.0126216524880575 0.0118035014556376 0.0 0.0002862261253737 0.0271584267040253 0.0 21212 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +689609 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.0100058569262237 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0117842887908422 0.0289462771086338 0.0 7.62660158633313e-05 0.015771296826767 0.0 3278 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +689618 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0100057357441157 0.7745997874735252 0.777821334064334 0.909150863993142 0.016822895653248 0.0108892901157311 0.0 0.0006072172102706 0.0753490791862989 0.0 5764 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +689699 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0100047596006326 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.0839650520556947 0.0053794918117879 0.0 0.0005818181818181 0.0473518648053582 0.0 6875 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +689767 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0100040198575981 0.6303642896310324 0.6331674633943454 1.0 0.0141923232885854 0.0176963220730796 0.0 0.0006081463322647 0.0805481053942617 0.0 21212 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +689937 CD34 SELP CD34-SELP Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0100017176299088 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.0082993421103349 0.04130664769978 0.0 0.0001962708537782 0.0749047414605904 0.0 5095 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +690291 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0099973063745462 0.8937519114898692 0.9078204025796472 0.9429656149619918 0.0037268694422441 0.0350138403862125 0.0 0.0005308680339755 0.030997825540115 0.0 3218 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +690332 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0099968697717755 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0799339500711946 0.0032078747392388 0.0 0.0001488095238095 0.0340676618309572 0.0 3360 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +690405 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0099957982900145 0.8913986641324685 0.6331674633943454 0.6198216015396206 0.0054950348959687 0.0518891167572028 0.0 0.0007780082987551 0.039819513863081 0.0 1687 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +690583 CXCL12 ITGA4 CXCL12-ITGA4 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0099934450388945 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0052742025956585 0.1076178292491983 0.0 0.0027804346375425 0.2329468415040665 0.0 4087 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +690632 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0099928473014303 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0673400749834054 0.0042655619249233 0.0 0.0002390710382513 0.0519277357678454 0.0 4880 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +690836 HSPG2 LRP1 HSPG2-LRP1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0099903763954746 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.1619074107723045 0.0018097844702233 0.0 0.0021367521367521 0.1900989444342853 0.0 377 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +690904 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0099896347149378 0.8949858186325867 0.4638256179742202 0.2461374514707439 0.001895566065636 0.5131068416842878 0.0 0.0012674271229404 0.0287924103532089 0.0 263 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +691183 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.009986101702556 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.1836996873148393 0.0016667952436519 0.0 0.002529383254574 0.3200048383406368 0.0 917 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +691256 MMRN2 CD93 MMRN2-CD93 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0099852249647584 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0002165306714062 1.0 0.0 0.0027985074626865 0.0166855609878641 0.0 536 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +691346 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0099841321167424 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0308750930304183 0.0176963220730796 0.0 0.0006290027447392 0.114984531306262 0.0 1093 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +691669 VWF ITGA9 VWF-ITGA9 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.009980287484422 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0019871862905238 0.1347191569099048 0.0 0.0016470963285691 0.0713908733504628 0.0 1711 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +691704 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.009979892046004 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0071496754272206 0.0501711964086628 0.0 0.0005329626489802 0.0108045557889666 0.0 3646 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +691737 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0099794461883433 0.4625081978296446 0.8381155706134242 0.2461374514707439 0.3558005706994493 0.0029095741067474 0.0 0.0 0.0 0.0 34 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +692469 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.009970523605319 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0101610580570933 0.0373075519081129 0.0 0.0050071530758226 0.0944794137196342 0.0 233 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +692474 C1QB LRP1 C1QB-LRP1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.009970490170584 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0161519521398178 0.0203874717835032 0.0 0.0006341958396752 0.0359147732910225 0.0 1971 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +692558 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0099694725002412 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0003788349535045 1.0 0.0 0.0030122967731286 0.0516377350129096 0.0 1154 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +692914 COL4A2 CD93 COL4A2-CD93 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0099654668172684 0.9188764516910942 0.6587114738285964 0.6198216015396206 0.0090193130488293 0.0289462771086338 0.0 5.7504312823461766e-05 0.0122425804270304 0.0 1739 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +693257 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0099613296402958 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0048525806497539 0.0587195251380622 0.0 7.478444483547424e-05 0.0180486718531887 0.0 5683 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +693593 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0099572570284174 0.6249837837987587 0.7746834992804791 1.0 0.0435116250366991 0.0046263543438723 0.0 0.0002239298510277 0.0787743063728631 0.0 21212 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +693624 C3 LRP1 C3-LRP1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0099569434204192 0.7148920381722296 0.8604147465201248 0.7204611100467462 0.005043231651446 0.0436001007095475 0.0 0.0001692047377326 0.0048374366787876 0.0 591 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +694020 CD48 CD2 CD48-CD2 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0099523249401015 0.4593282471594782 0.4603649459881741 0.8767341187813953 0.0467114894617178 0.0112209532878862 0.0 0.0020408163265306 0.4009838637836608 0.0 2450 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +694045 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0099520109309926 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0083898580598364 0.0218093597373452 0.0 0.0053034467314073 0.2874220679315827 0.0 2339 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +694108 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0099511256436145 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0012306151710811 0.2295016807597237 0.0 0.0 0.0 0.0 126 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +694570 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0099456227092455 0.2542249848376565 0.7283139964676212 0.2461374514707439 0.1711385759005754 0.0124087765732037 0.0 0.0039215686274509 0.1933318175933115 0.0 272 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +694682 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0099444670531935 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0071496754272206 0.0487643047611538 0.0 0.0003490749513788 0.0136637892073313 0.0 3646 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +694758 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0099435792368023 0.9303167350027568 0.8819126042133903 0.9429656149619918 0.0016860250240652 0.0741032966028748 0.0 0.0004661280298321 0.0234355341894423 0.0 3218 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +694867 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0099423246588763 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0255753403203798 0.0215025911544899 0.0 0.0011381419832124 0.136731454058827 0.0 1278 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +695095 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0099396469889355 0.6249837837987587 0.4638256179742202 0.2461374514707439 0.00263399584678 0.5131068416842878 0.0 0.0055292259083728 0.1335485463705348 0.0 211 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +695235 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.009938048961152 0.4630253981438691 0.6587114738285964 0.2461374514707439 0.0443339118517084 0.0289462771086338 0.0 0.0 0.0 0.0 186 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +695403 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.009936104144111 0.7487535481622718 0.7754239189773715 0.8567148457705164 0.0131092554497256 0.0147571931436988 0.0 0.0046449900464499 0.0930208219044602 0.0 137 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +695541 CD34 SELP CD34-SELP Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0099345001756468 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.0082993421103349 0.0335947364052305 0.0 0.0 0.0 0.0 1093 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +695705 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0099326958955288 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2966815529783992 0.0018097844702233 0.0 0.0018518518518518 0.2498731371878917 0.0 135 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +695724 VEGFC FLT1 VEGFC-FLT1 Pericytes B Cells Pericytes -> B Cells 0.0099323847070362 0.8718210606749883 0.777821334064334 0.6198216015396206 0.1796394187986057 0.001271575589586 0.0 0.0007839448102853 0.1919876145217954 0.0 1063 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +695755 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0099320591263625 0.785133132759182 0.930308383061206 0.7827641335561659 0.001039571291679 0.1615013370958009 0.0 0.0054627249357326 0.16871681848713 0.0 389 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +695978 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0099293329736568 0.7487535481622718 0.4600037439857229 0.2461374514707439 0.0637288077574987 0.017738069381683 0.0 0.0009524263060145 0.2374494971309944 0.0 1909 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +696218 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0099257799863359 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0016171311116606 0.1886404570313 0.0 0.0005914160189253 0.0154674402739169 0.0 2152 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +696703 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0099196915972656 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0037159398684439 0.0627790816848129 0.0 0.002960769800148 0.0594510729752584 0.0 193 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +696729 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0099193641359066 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0104129581710415 0.0326667674102811 0.0 0.000632911392405 0.0126474497523517 0.0 79 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +696760 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0099190113476052 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0048525806497539 0.0416128058995347 0.0 0.0003848195329087 0.0359423890851732 0.0 1884 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +697053 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0099154025441073 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0131092554497256 0.0292373734098458 0.0 0.0004584057131827 0.070001164686693 0.0 1884 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +697114 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0099147762287109 0.6319926036888139 0.6207977546603366 0.8693461273411047 0.0265972645862203 0.0104714078116759 0.0 0.000391304347826 0.0385060237946697 0.0 575 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +697177 CD48 CD2 CD48-CD2 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0099140648463915 0.4593282471594782 0.8960994285623033 0.6198216015396206 0.0161888123016941 0.0229905310518441 0.0 0.000734214390602 0.034616046605949 0.0 1362 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +697192 VWF LRP1 VWF-LRP1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0099139240142889 0.8525936146535493 0.7346293219749174 0.7204611100467462 0.0002103933337194 1.0 0.0 0.0022268797484935 0.0170968929250571 0.0 1041 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +697467 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0099109014543326 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.0198024073017111 0.0118035014556376 0.0 0.0 0.0 0.0 83 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +697779 CD34 SELP CD34-SELP Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.009907191909751 0.9559599666576516 0.8819126042133903 0.9429656149619918 1.0 0.0001189339410417 0.0 0.000194855806703 1.0 0.0 2566 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +697792 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0099070816701677 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0072827533047186 0.0350138403862125 0.0 0.001429199648197 0.0611855139945189 0.0 379 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +697819 VWF SELP VWF-SELP Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0099067654499683 0.955713094717548 0.8819126042133903 0.9429656149619918 1.0 0.0001189339410417 0.0 5.3142492737192655e-05 0.3341075857967107 0.0 2566 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +697835 C1QB LRP1 C1QB-LRP1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0099065758624407 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.0037630364713574 0.0587195251380622 0.0 0.0005489335006273 0.0467830590917673 0.0 797 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +697964 CD48 CD2 CD48-CD2 Pericytes B Cells Pericytes -> B Cells 0.0099048174128076 0.7719609236370527 0.937587088419394 0.6198216015396206 0.0076331962782219 0.0275738893167071 0.0 0.0014111006585136 0.0588546633484642 0.0 1063 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +698455 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0098989958080786 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0342558468646473 0.0083242517891534 0.0 0.0030039718386601 0.3514233458142721 0.0 3321 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +698607 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0098970484624012 0.7783550150988336 0.8347945881127203 0.6198216015396206 0.1928969878996252 0.0012097093680331 0.0 0.0 0.0 0.0 18 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +698737 CCN1 CAV1 CCN1-CAV1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0098954862223609 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0023088899408624 0.1449812920932466 0.0 0.0005627599706386 0.0461281391162693 0.0 4087 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +698751 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0098952767880978 0.6593525851613742 0.878254460598671 0.6198216015396206 0.4518617096918393 0.0005788283879716 0.0 0.0005464480874316 0.5897673745655713 0.0 4880 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +698781 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0098948926739756 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.0142750905665976 0.0203874717835032 0.0 0.0029054916985951 0.172278325955394 0.0 1305 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +698951 A2M LRP1 A2M-LRP1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0098924898074754 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.0149044683666724 0.0144359394371152 0.0 0.000961269574944 0.1179343136985467 0.0 4768 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +699064 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0098912422080354 0.6332974881236617 0.6207977546603366 0.9161861017439124 0.0015572459193676 0.166956519448744 0.0 0.0013646288209606 0.0102821539545605 0.0 458 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +699430 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0098868607588294 0.6582846571368821 0.6587114738285964 0.8824495942126559 0.0084325366891025 0.0289462771086338 0.0 0.0002646815550041 0.0563502990573522 0.0 12090 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +699821 COL4A2 CD93 COL4A2-CD93 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0098824045799131 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0267593032157803 0.0155837683010033 0.0 0.000599520383693 0.1657349987002249 0.0 3336 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +700040 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0098798670487632 0.8023917560710954 0.8622452992050237 0.6198216015396206 0.0085367158000785 0.0254056950469408 0.0 0.0006082644628099 0.0955769352278736 0.0 6875 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +700086 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0098794056900321 0.6303682835571691 0.773263018678637 0.8875000050982297 0.0291791383241764 0.0073658308476012 0.0 0.0037763654784931 0.6875798717462346 0.0 2585 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +700150 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0098786184528344 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.0051524613572059 0.0606066271159369 0.0 0.0 0.0 0.0 3 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +700210 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0098779816427984 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0073929685753755 0.0689186266365139 0.0 0.0006128014216992 0.0576300450154656 0.0 10879 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +700397 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0098755761196449 0.2490567623945399 0.6580560501976399 0.2461374514707439 0.011649387573427 0.1973932010691654 0.0 0.0 0.0 0.0 147 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +700433 C1QB LRP1 C1QB-LRP1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0098752499541286 0.8703788833238396 0.6207977546603366 0.909150863993142 0.0037630364713574 0.0501711964086628 0.0 0.0010894125242091 0.0259476714742349 0.0 1549 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +700605 CD34 SELP CD34-SELP CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0098729021967842 0.7168245244832976 0.4623922682986163 0.2461374514707439 0.1173076386135379 0.0096770075292062 0.0 0.0004346314325452 0.394318872824997 0.0 5752 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +700647 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.009872386448267 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.0141498126994191 0.0293997450046583 0.0 0.003690036900369 0.2275062343455045 0.0 271 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +701159 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0098665995471524 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0106340017102282 0.0293031867940321 0.0 0.0002551386519111 0.0319307176827517 0.0 5701 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +701195 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0098661225273891 0.6213271600240247 0.7832252605020791 0.6198216015396206 0.2247035641022029 0.00136079311934 0.0 0.006060606060606 0.8909147415311304 0.0 143 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +701217 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0098658451440558 0.4625081978296446 0.657421674383923 0.6198216015396206 0.0704104148800194 0.0069492509109592 0.0 0.0003201024327784 0.0547780166523511 0.0 1562 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +701393 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0098635516518651 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0015572459193676 0.1886404570313 0.0 0.0007662835249042 0.0200407907041139 0.0 1305 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +701400 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0098634931984861 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0008193633790489 0.3162217004298525 0.0 2.9327233268813417e-05 0.0033778195928587 0.0 5683 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +701799 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0098586038789859 0.2534163760166434 0.7746834992804791 0.2461374514707439 0.2100740470724093 0.0090444648829713 0.0 0.0025217790004585 0.3548145042038046 0.0 727 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +701883 MMRN2 CD93 MMRN2-CD93 Pericytes Mast Cells Pericytes -> Mast Cells 0.0098576591195238 0.9468422434493456 0.8347945881127203 0.8567148457705164 0.1120119983652299 0.0012097093680331 0.0 0.0044444444444444 0.2358490566037739 0.0 225 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +701916 CD34 SELP CD34-SELP Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0098573117127659 0.9303167350027568 0.4623922682986163 0.7204611100467462 0.1314667522621683 0.0022515473538965 0.0 0.0 0.0 0.0 394 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +702047 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells B Cells Mast Cells -> B Cells 0.0098555429458953 0.831981591331937 0.7763400818577846 0.6198216015396206 0.0048935684578858 0.0467761235673353 0.0 0.0029761904761904 0.1673677627640469 0.0 112 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +702161 HSPG2 LRP1 HSPG2-LRP1 Pericytes B Cells Pericytes -> B Cells 0.009854269856068 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.1619074107723045 0.0016667952436519 0.0 0.0030181875195986 0.3818458936755767 0.0 1063 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +702298 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0098525594567732 0.662063103571249 0.930308383061206 0.6198216015396206 0.585843718590581 0.0004089864655001 0.0 0.0001408811475409 0.1810757970155722 0.0 4880 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +702452 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0098507202574695 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0415873844357376 0.0053794918117879 0.0 0.0002208646616541 0.0179752952481571 0.0 30400 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +702826 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0098463123936767 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.0070489045197697 0.0350138403862125 0.0 0.001207729468599 0.0705203270329375 0.0 345 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +703101 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0098428681801237 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0072827533047186 0.0416128058995347 0.0 0.0031707127295362 0.1046995176826117 0.0 714 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +703146 COL4A2 CD93 COL4A2-CD93 Mast Cells Pericytes Mast Cells -> Pericytes 0.0098424029639097 0.8355319038299565 0.8817184225858201 0.8567148457705164 0.001123788079051 0.1281708518900828 0.0 0.0012295081967213 0.0347808885304186 0.0 244 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +703368 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0098398495181227 0.6630837220165452 0.944024288971064 0.6198216015396206 0.0048313935743179 0.0484215930647349 0.0 0.0 0.0 0.0 103 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +703634 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0098366899830209 0.6303642896310324 0.9015117569158254 0.6198216015396206 0.0104129581710415 0.0246995741084876 0.0 0.001 0.05089906087561 0.0 475 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +703643 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0098365959484749 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0323110954490285 0.0073658308476012 0.0 0.0022008803521408 0.4007241986698956 0.0 119 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +703758 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0098351387873243 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0106340017102282 0.0484993884807927 0.0 0.0017652250661959 0.0250952872480364 0.0 103 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +703907 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0098334945120053 0.7800321422220979 0.6331674633943454 0.909150863993142 0.0113788029360913 0.0176963220730796 0.0 0.0004961155210268 0.0906921490186545 0.0 5921 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +703945 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0098332102524059 0.8730912658940219 0.8628183098412396 0.6198216015396206 0.0057086106530109 0.0339152418223636 0.0 0.0043290043290043 0.3307459221408657 0.0 126 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +703974 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0098328826627857 0.4636527906642655 0.878254460598671 0.7204611100467462 0.0023125636768155 0.1332188634280341 0.0 0.0033185840707964 0.1250779546853167 0.0 452 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +704571 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0098258378443635 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0135527119637784 0.0203874717835032 0.0 0.0011617100371747 0.065788120963388 0.0 2152 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +704607 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0098253597044888 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.1194227711616854 0.0041555861088636 0.0 0.0002682403433476 0.0340663370729313 0.0 233 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +704998 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0098207702199142 0.7783550150988336 0.7779918296243433 0.8693461273411047 0.0316800311254893 0.0053794918117879 0.0 0.0009497964721845 0.1025320317845457 0.0 737 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +705060 VWF ITGA9 VWF-ITGA9 Macrophages Pericytes Macrophages -> Pericytes 0.0098199527659515 0.9011206516381156 0.9404022517663844 0.8875000050982297 0.0008850282134344 0.1347191569099048 0.0 0.0009553906077754 0.0414099459132225 0.0 2474 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +705090 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0098196717987072 0.8978557803479422 0.8381155706134242 0.8567148457705164 0.0477973731763516 0.0029095741067474 0.0 0.0 0.0 0.0 165 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +705096 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0098196088273382 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0425206505665654 0.0059327142047454 0.0 0.0016025641025641 0.4294019811035471 0.0 312 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +705326 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0098168749640136 0.7487535481622718 0.7754239189773715 0.9429656149619918 0.1027229557481577 0.0015914585039484 0.0 0.000850279883795 0.4128024705553348 0.0 2566 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +705396 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0098158698255311 0.7487535481622718 0.7447682696221608 0.7827641335561659 0.0637288077574987 0.0032154705418133 0.0 0.004602991944764 0.39072124471954 0.0 316 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +705471 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0098150175994303 0.7160288858520609 0.4641352222874551 0.8293805866303694 0.0069047442087267 0.046975263367762 0.0 0.0004168403501458 0.0689617949018248 0.0 7197 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +705513 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0098145435025437 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0097699360831605 0.0326667674102811 0.0 0.0002427184466019 0.0048502355846397 0.0 103 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +705543 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0098143163372323 0.6301823358791634 0.7779918296243433 0.909150863993142 0.0031934983073077 0.0627790816848129 0.0 0.0009108258154059 0.0199454110134147 0.0 5764 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +705901 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0098105129440408 0.6593525851613742 0.777821334064334 0.7917001487310438 0.0120646829101097 0.0182001711419816 0.0 0.0008424599831508 0.10090351260537 0.0 1187 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +705952 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0098099084909764 0.6593525851613742 0.777821334064334 0.7917001487310438 0.0201572483258557 0.0108892901157311 0.0 0.0055821371610845 0.6926827630459763 0.0 209 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +706113 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0098078413060345 0.6160088550075702 0.9255624071030766 0.7917001487310438 0.0001971810371238 1.0 0.0 0.0026350461133069 0.0212054258187084 0.0 69 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +706347 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0098051091182961 0.7296454584598743 0.7470475610360806 0.7204611100467462 0.293296467876477 0.0007714919761827 0.0 0.0 0.0 0.0 51 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +706350 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0098050843326604 0.6605327397359113 0.9130058539314824 0.6198216015396206 0.0179229861158654 0.0132636308162813 0.0 0.0 0.0 0.0 119 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +706785 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0097995531071619 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.0201572483258557 0.0232163927704059 0.0 0.0009337068160597 0.1826946363964239 0.0 714 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +706800 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0097993367996362 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0073929685753755 0.0362497659817488 0.0 0.0 0.0 0.0 81 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +706873 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.009798431976432 0.6659645551150886 0.8960994285623033 0.7917001487310438 0.0081474500750471 0.0229905310518441 0.0 0.0019238991021804 0.0907061777032327 0.0 2339 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +706972 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0097973751816935 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2966815529783992 0.0016667952436519 0.0 0.0022448015122873 0.4507733385392771 0.0 4232 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +707012 THBS2 CD36 THBS2-CD36 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0097969350191474 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0087456089304998 0.02871400543887 0.0 0.0001208780582148 0.0584947266828562 0.0 6894 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +707569 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0097904162790432 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0106340017102282 0.0279580382843415 0.0 0.0002255808707421 0.031632887991693 0.0 4836 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +707698 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0097889884949495 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.1027229557481577 0.0027830389352876 0.0 0.0 0.0 0.0 312 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +707784 VWF SELP VWF-SELP Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0097876788367109 0.9275752708651288 0.4623922682986163 0.7204611100467462 0.1263644540569636 0.0022515473538965 0.0 0.0029995385325334 0.2894505831475691 0.0 394 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +707965 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0097856048572671 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.0693389464442948 0.0066828239855783 0.0 0.0004981071926678 0.0613546831732854 0.0 1673 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +708002 THBS2 CD36 THBS2-CD36 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.0097851473521466 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0039472834455595 0.0455125113141721 0.0 0.0003048343135848 0.0693154477610826 0.0 13942 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +708210 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0097824927842385 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.0070489045197697 0.0416128058995347 0.0 0.0040470934510669 0.240073085204205 0.0 453 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +708528 VWF ITGA9 VWF-ITGA9 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0097788011055944 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.00023686843287 1.0 0.0 0.0010844026748599 0.012108431809431 0.0 1509 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +708680 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0097767856884045 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0236359933700329 0.0125623889131764 0.0 0.0008116883116883 0.3768537962421833 0.0 77 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +708802 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0097755186241741 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0323110954490285 0.0070956399217802 0.0 0.0052449965493443 0.6582656514633752 0.0 345 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +708816 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.009775301422924 0.8498991475190484 0.6207977546603366 0.8693461273411047 0.018166235813628 0.0104714078116759 0.0 0.0007608695652173 0.0760989672203925 0.0 575 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +709107 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0097718577690933 0.6342079770588467 0.6571792026963191 1.0 0.0085570823799139 0.0244129856070659 0.0 0.003221649484536 0.1131414802241481 0.0 1552 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +709318 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0097690001550954 0.6301823358791634 0.7779918296243433 0.8693461273411047 0.0172764782878141 0.0118035014556376 0.0 0.0013043478260869 0.0999322306234461 0.0 575 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +709437 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0097676871684779 0.4619393085577573 0.7167436199046466 0.8293805866303694 0.1194227711616854 0.0026482500471321 0.0 0.0003659767794043 0.136564605873893 0.0 9905 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +709465 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0097673737266114 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.016822895653248 0.0232163927704059 0.0 0.0 0.0 0.0 1278 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +709484 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0097671722731105 0.9470274865242416 0.4638256179742202 0.7204611100467462 0.0061455194924501 0.0446401662952339 0.0 0.0001326963906581 0.0149745546671197 0.0 1884 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +709538 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0097666379507581 0.6342079770588467 0.7754072541855492 1.0 0.0073929685753755 0.0238720285974944 0.0 0.0002828587591929 0.0689507298378827 0.0 21212 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +709781 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0097636460105949 0.6160088550075702 0.9008184599638702 0.7917001487310438 0.0001971810371238 1.0 0.0 0.0013175230566534 0.0106306997312189 0.0 69 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +710127 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0097595047076972 0.2542249848376565 0.942159351720962 0.2461374514707439 0.0014656941948563 1.0 0.0 0.0244444444444444 0.360221878480048 0.0 15 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +710195 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0097587363201033 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0028649117803088 0.0855781119790033 0.0 0.0005844535359438 0.0294505806414637 0.0 1711 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +710562 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0097547550946203 0.7324582304061453 0.252518874138558 0.2461374514707439 1.0 0.0018925243453249 0.0 0.0056521739130434 0.3130960258456272 0.0 230 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +710622 VWF SELP VWF-SELP CAFs, DCIS Associated 11q13 Invasive Tumor Cells CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells 0.009753916279099 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0071496754272206 0.04130664769978 0.0 5.546619335515004e-05 0.0188260296131228 0.0 3278 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +710699 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0097528928021657 0.4629984640915818 0.8604147465201248 0.2461374514707439 0.0201301851612071 0.0436001007095475 0.0 0.0051926926926926 0.1193317771304879 0.0 222 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +710714 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0097527285928988 0.9470274865242416 0.6580560501976399 0.6198216015396206 0.0061455194924501 0.0362497659817488 0.0 0.0012224938875305 0.0416937837445049 0.0 409 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +711173 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0097469957353928 0.4630253981438691 0.8347945881127203 0.7204611100467462 0.2545335314555431 0.0012097093680331 0.0 0.0026315789473684 0.1557509645910166 0.0 38 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +711429 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0097439131896225 0.662063103571249 0.6331674633943454 1.0 0.0491302556793708 0.0041555861088636 0.0 0.0014497422680412 0.1841162599018993 0.0 1552 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +711564 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.009742547658209 0.4619393085577573 0.7167436199046466 0.2461374514707439 0.0835287751665837 0.0125623889131764 0.0 0.0003714900594384 0.1724768450520179 0.0 4879 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +712210 VWF SELP VWF-SELP Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0097350863683266 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0025256125075084 0.0741032966028748 0.0 0.0 0.0 0.0 1931 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +712402 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0097327429900396 0.6303642896310324 0.9015117569158254 0.6198216015396206 0.0097699360831605 0.0246995741084876 0.0 0.0004071058475203 0.0207213053157553 0.0 1351 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +712499 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0097315683233961 0.662063103571249 0.8537710813834968 0.6198216015396206 0.585843718590581 0.0004138063814779 0.0 0.0 0.0 0.0 42 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +712559 CXCL12 CXCR4 CXCL12-CXCR4 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0097308594624614 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0052742025956585 0.049767778498468 0.0 5.703205201323144e-05 0.0194904456043582 0.0 797 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +712752 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.00972854175773 0.2542249848376565 0.62431395375366 0.2461374514707439 0.1711385759005754 0.0126805820762719 0.0 0.0020042194092827 0.4083107698438155 0.0 316 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +712779 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0097281709342928 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0244483651952677 0.0090444648829713 0.0 0.001993620414673 0.2805025495391104 0.0 209 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +712845 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0097274095685267 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0014431743145616 0.1615013370958009 0.0 0.0004617414248021 0.0142609311420287 0.0 379 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +714443 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0097082077066121 0.7783550150988336 0.4630027772793905 0.2461374514707439 0.1928969878996252 0.0048929293424311 0.0 0.0009122006841505 0.2949538158033873 0.0 877 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +714624 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0097063586826493 0.4629984640915818 0.6207977546603366 0.2461374514707439 0.0201301851612071 0.0587195251380622 0.0 0.0004480286738351 0.0315886706693911 0.0 186 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +714819 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0097042327134877 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0338862305197021 0.0080072638027924 0.0 0.0003021350879548 0.0729809891288453 0.0 1354 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +715127 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0097004705754959 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0131302879503246 0.0203874717835032 0.0 0.0002381130382775 0.0111491115083154 0.0 30400 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +715133 CD48 CD2 CD48-CD2 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.009700403458745 0.4593282471594782 0.4603649459881741 1.0 0.0351142257737683 0.0112209532878862 0.0 9.481269225907042e-05 0.0186289962421088 0.0 94924 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +716129 HSPG2 LRP1 HSPG2-LRP1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0096887042163328 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0012941512528773 0.166956519448744 0.0 0.0048065886134067 0.02696434927824 0.0 968 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +716157 VWF SELP VWF-SELP CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0096883641963841 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0071496754272206 0.0335947364052305 0.0 0.000168437216007 0.0090105673303685 0.0 11604 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +716204 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0096878062514894 0.6605327397359113 0.885766439573873 0.6198216015396206 0.0179229861158654 0.0127192475389894 0.0 0.0004830917874396 0.0728620949889089 0.0 345 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +716234 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0096874309743277 0.6160088550075702 0.8628183098412396 0.8693461273411047 0.0052742025956585 0.0339152418223636 0.0 0.0007575757575757 0.0578805363746515 0.0 360 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +716281 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.009686955815291 0.8913986641324685 0.7167436199046466 0.7204611100467462 0.0054950348959687 0.0326667674102811 0.0 0.0017254601226993 0.0365260328210978 0.0 326 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +716376 C3 LRP1 C3-LRP1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0096858383121272 0.9487258305485792 0.6207977546603366 0.6198216015396206 0.0110943464444434 0.0203874717835032 0.0 0.0018939393939393 0.2422565038438113 0.0 594 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +716384 C3 LRP1 C3-LRP1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0096857540055075 0.7148920381722296 0.9078204025796472 0.7204611100467462 0.005043231651446 0.0350138403862125 0.0 0.0005049197307094 0.0443554419641124 0.0 1931 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +716644 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0096822702800817 0.7797302331085993 0.8381155706134242 0.6198216015396206 0.0699064461360958 0.0029095741067474 0.0 0.0 0.0 0.0 18 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +716765 THBS2 CD36 THBS2-CD36 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0096808009867282 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0063387366560491 0.0455125113141721 0.0 0.0003485308085914 0.0792514752422244 0.0 10879 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +716866 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0096794908135945 0.8533682807143209 0.6587114738285964 0.7917001487310438 0.0706049302656684 0.0026174949623928 0.0 0.0015624999999999 0.1523055471809427 0.0 1280 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +717152 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0096759347757364 0.7463064942968751 0.8817184225858201 0.7827641335561659 0.0012430446376512 0.1281708518900828 0.0 0.001652589056188 0.0389398146084521 0.0 389 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +717260 VWF SELP VWF-SELP B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0096747019502973 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.00023686843287 1.0 0.0 0.0021688053497198 0.0121951357249531 0.0 1509 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +717264 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0096746767345708 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0002327631000826 1.0 0.0 0.001325381047051 0.0182526902360693 0.0 1509 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +717622 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0096697579133137 0.4636527906642655 0.4630488285702799 0.2461374514707439 0.0666348171285698 0.0232163927704059 0.0 0.0010103277952402 0.1976867535052907 0.0 13362 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +717832 VWF LRP1 VWF-LRP1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0096672594367234 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.1263644540569636 0.0018097844702233 0.0 0.0015975403906438 0.1659595121416607 0.0 377 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +717883 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0096667084863304 0.6342079770588467 0.4638256179742202 0.2461374514707439 0.002196330917593 0.5131068416842878 0.0 0.0 0.0 0.0 155 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +717890 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0096666485763144 0.8730912658940219 0.7754239189773715 0.7204611100467462 0.0057086106530109 0.0293031867940321 0.0 0.0019106999195494 0.2391249591176708 0.0 452 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +717999 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0096653582418561 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0149256517769723 0.0310998965832685 0.0 0.0030112273817309 0.5682581663652071 0.0 3336 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +718109 C3 LRP1 C3-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0096640303560547 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.005043231651446 0.0587195251380622 0.0 0.0002355250245338 0.0568422202020461 0.0 5095 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +718120 THBS2 CD36 THBS2-CD36 B Cells Pericytes B Cells -> Pericytes 0.0096639351204854 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0008527942416386 0.287457858136305 0.0 0.0009633911368015 0.0293001151643118 0.0 1211 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +718213 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Macrophages B Cells -> Macrophages 0.0096627433970999 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0052742025956585 0.0521257226458961 0.0 0.0031156636790439 0.1303043920832235 0.0 1065 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +718428 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0096603313081824 0.8023917560710954 0.4600037439857229 0.8293805866303694 0.0085367158000785 0.0310998965832685 0.0 0.0006252605252188 0.1179948753511793 0.0 7197 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +719252 CD48 CD2 CD48-CD2 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0096502744984462 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0112468593062777 0.0226890201466244 0.0 0.0 0.0 0.0 78 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +719803 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0096433421604335 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0016171311116606 0.1347191569099048 0.0 0.0007155379056205 0.0310138970693889 0.0 2541 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +720148 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0096390742424412 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0491302556793708 0.0049190726392343 0.0 0.0 0.0 0.0 42 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +720203 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0096383201658569 0.6593525851613742 0.777821334064334 0.7917001487310438 0.018132161410931 0.0108892901157311 0.0 0.0006412997007268 0.0795783471135089 0.0 2339 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +720239 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.0096378634686779 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0291791383241764 0.0083242517891534 0.0 0.0018083838540857 0.2115560127230595 0.0 4595 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +720416 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0096359277965633 0.8730912658940219 0.6631822525600675 0.6198216015396206 0.0057086106530109 0.0390724515618796 0.0 0.0012285012285012 0.6941267016602258 0.0 148 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +720539 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0096344260964585 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.000895875398841 0.2295016807597237 0.0 0.0002808199943836 0.0139597400342459 0.0 1187 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +720979 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0096292801628808 0.6160088550075702 0.6632137581773894 0.9161861017439124 0.0548063857429699 0.0038860320327025 0.0 0.000691699604743 0.3912800447177198 0.0 460 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +721086 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0096281459114552 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.018132161410931 0.0232163927704059 0.0 0.0002969121140142 0.0580955925120457 0.0 1684 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +721100 C1QB LRP1 C1QB-LRP1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0096280119807875 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0026949121497638 0.166956519448744 0.0 0.0030701754385964 0.0325304994340639 0.0 285 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +721300 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0096254935091397 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.0085570823799139 0.0238720285974944 0.0 0.0 0.0 0.0 83 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +721495 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0096232454325567 0.6213271600240247 0.62431395375366 0.7917001487310438 0.1339639999453202 0.0019304335593669 0.0 0.0004093567251461 0.1010672577656726 0.0 570 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +721497 HSPG2 LRP1 HSPG2-LRP1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0096231698460847 0.8349903778527206 0.6207977546603366 0.6198216015396206 0.0014804857410621 0.166956519448744 0.0 0.0117669753086419 0.0660112311849717 0.0 144 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +721694 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0096209349462786 0.6342079770588467 0.6571792026963191 0.8824495942126559 0.0673400749834054 0.0032020139126304 0.0 0.0002495840266222 0.08050753200993 0.0 12020 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +721838 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.009619306106681 0.6160088550075702 0.6631822525600675 0.9161861017439124 0.0548063857429699 0.0038621268649178 0.0 0.0016418942274455 1.0 0.0 526 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +721990 CD48 CD2 CD48-CD2 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.009617303401249 0.9011089648206808 0.6614977577544194 0.7917001487310438 0.4567172527116189 0.0003671083100858 0.0 0.0 0.0 0.0 209 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +722056 CD34 SELP CD34-SELP Pericytes Mast Cells Pericytes -> Mast Cells 0.0096165122730146 0.9303167350027568 0.8347297932672282 0.8567148457705164 0.1314667522621683 0.0009042150166242 0.0 0.0044444444444444 0.7117437722419931 0.0 225 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +722115 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0096156140902045 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0149256517769723 0.0178869147172998 0.0 0.0022895311712317 0.391398649074518 0.0 2164 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +722700 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0096091923034849 0.4625081978296446 0.657421674383923 0.6198216015396206 0.0704104148800194 0.0059327142047454 0.0 0.0 0.0 0.0 422 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +722954 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0096059991322658 0.4604235282221027 0.4630027772793905 0.8767341187813953 0.454846709299195 0.0009242223287825 0.0 0.0013103488439811 0.252764688162521 0.0 2453 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +724029 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0095930358649585 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0025256125075084 0.1112417752963437 0.0 0.0002676420733339 0.0289303809363528 0.0 5095 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +724129 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0095920091955746 0.8730912658940219 0.7757991160529997 0.7204611100467462 0.0057086106530109 0.0279580382843415 0.0 0.0020352781546811 0.2854041909101257 0.0 536 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +724306 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0095897577688045 0.8949858186325867 0.4641352222874551 0.7204611100467462 0.001895566065636 0.1370986982961073 0.0 0.0013986013986013 0.0450556783767705 0.0 715 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +724401 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0095884707865016 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.1496557267835524 0.0016204239758814 0.0 0.0 0.0 0.0 1351 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +724482 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0095874739975043 0.6213271600240247 0.8617632615906476 0.6198216015396206 0.2247035641022029 0.0010414441948928 0.0 0.0082051282051282 1.0 0.0 130 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +724573 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0095864250321925 0.8818165186409654 0.8604147465201248 0.8875000050982297 0.0026436039558049 0.0436001007095475 0.0 0.0007607677902621 0.0174829857586937 0.0 1424 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +724816 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0095835973564406 0.8721681415062816 0.8381155706134242 0.8567148457705164 0.0425206505665654 0.0029095741067474 0.0 0.0007407407407407 0.0233969900088529 0.0 225 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +724883 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0095828845316928 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0015572459193676 0.1347191569099048 0.0 0.0009594627008875 0.0415864445663943 0.0 379 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +725133 C3 LRP1 C3-LRP1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0095797261287237 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0042375227960614 0.0587195251380622 0.0 6.273525721455459e-05 0.0151406896659047 0.0 797 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +725210 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0095786521867516 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0799339500711946 0.0053213839468185 0.0 9.68429207824908e-05 0.0379335650450003 0.0 5163 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +725747 HSPG2 LRP1 HSPG2-LRP1 Macrophages Macrophages Macrophages -> Macrophages 0.009572223997764 0.9253089325030373 0.8604147465201248 1.0 0.0022161183602947 0.0436001007095475 0.0 0.0010622909321037 0.0244122023504173 0.0 2458 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +725778 DLL4 NOTCH3 DLL4-NOTCH3 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0095718970993732 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0002327631000826 1.0 0.0 0.0002091175240485 0.0113687542101148 0.0 797 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +725967 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Macrophages B Cells -> Macrophages 0.0095699906154232 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0052742025956585 0.0491709261488903 0.0 0.0023047375160051 0.1040069834893555 0.0 1065 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +726043 VWF ITGA9 VWF-ITGA9 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0095693199807739 0.6332974881236617 0.863034163938375 0.6198216015396206 0.0036144684673052 0.0627102121186242 0.0 0.0008190008190008 0.0065789069716238 0.0 333 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +726085 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0095688278164324 0.8560892486218385 0.930308383061206 0.8567148457705164 0.0006966068981631 0.1615013370958009 0.0 0.0017418032786885 0.0537957724520439 0.0 244 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +726099 CD34 SELP CD34-SELP CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0095686377896776 0.7168245244832976 0.4623922682986163 0.8767341187813953 0.1173076386135379 0.0022515473538965 0.0 0.0004076640847941 0.0338875000175695 0.0 2453 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +726412 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0095650430322516 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0149256517769723 0.0292373734098458 0.0 0.001770538243626 0.2703712794407011 0.0 1412 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +726471 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0095643547223896 0.6303682835571691 0.4614667734221426 0.8293805866303694 0.0101610580570933 0.0312252462757311 0.0 0.0008653638133698 0.0471311175428929 0.0 9905 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +726516 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0095636853615376 0.8023917560710954 0.4600037439857229 0.8293805866303694 0.0085367158000785 0.0292791515533623 0.0 0.0029057700290577 0.0686121304042948 0.0 219 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +726701 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0095616452413612 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.7696906278989153 0.0003375370073613 0.0 0.0002178649237472 0.169258807662201 0.0 11475 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +727022 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.009557634474795 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0637288077574987 0.0038860320327025 0.0 0.0002411381721726 0.1364068363547943 0.0 377 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +727074 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0095570083060421 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.1740454925211078 0.001079730675535 0.0 0.0005263157894736 0.0890080743613357 0.0 570 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +727077 CCN1 CAV1 CCN1-CAV1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0095569906688907 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0023088899408624 0.1176565474247238 0.0 0.0004704301075268 0.0323137015221926 0.0 496 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +727136 C1QB LRP1 C1QB-LRP1 B Cells Macrophages B Cells -> Macrophages 0.0095561952575674 0.8703788833238396 0.8604147465201248 0.6198216015396206 0.0037630364713574 0.0436001007095475 0.0 0.0021713615023474 0.0509060141947011 0.0 1065 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +727152 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0095559394311399 0.7296454584598743 0.4638256179742202 0.8293805866303694 0.293296467876477 0.0009249287638231 0.0 0.0007610350076103 0.4381413354903908 0.0 219 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +727252 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0095547063900662 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.0142750905665976 0.0144359394371152 0.0 0.0038288288288288 0.4697436722923541 0.0 370 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +727273 C3 LRP1 C3-LRP1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0095544842035513 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0334108479684367 0.0064028969591119 0.0 0.000625 0.1184087698578323 0.0 1880 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +727597 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0095503119921332 0.8640667164982425 0.2491073778594529 0.2461374514707439 0.1882781599600688 0.0076066460958003 0.0 0.0008184913567312 0.3409897484842016 0.0 1909 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +727630 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0095498878253151 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.4344545964241579 0.0009242223287825 0.0 0.0055335968379446 1.0 0.0 253 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +727662 C3 LRP1 C3-LRP1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0095494337626699 0.6319926036888139 0.6207977546603366 0.909150863993142 0.0042375227960614 0.0501711964086628 0.0 0.0016946417043253 0.0487600295251241 0.0 1549 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +727695 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0095490891606262 0.7835752212271604 0.4638256179742202 0.7204611100467462 0.0064863313435223 0.0446401662952339 0.0 0.0019607843137254 0.2212710666106166 0.0 85 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +727709 C3 LRP1 C3-LRP1 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.0095489224831448 0.8911088195487638 0.9078204025796472 1.0 0.0064915662046245 0.0144359394371152 0.0 0.0004440879568041 0.0758389855119665 0.0 12779 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +727730 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0095487281719245 0.2490567623945399 0.6571792026963191 0.2461374514707439 0.011649387573427 0.1615138601457002 0.0 0.0 0.0 0.0 186 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +727748 VWF SELP VWF-SELP Pericytes Mast Cells Pericytes -> Mast Cells 0.0095485804243827 0.9275752708651288 0.8347297932672282 0.8567148457705164 0.1263644540569636 0.0009042150166242 0.0 0.0014141414141414 0.1157790274561695 0.0 225 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +727770 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0095483226847801 0.7783550150988336 0.7779918296243433 0.8693461273411047 0.0267593032157803 0.0053794918117879 0.0 0.0014457831325301 0.1560745764376115 0.0 1245 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +727816 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0095477346295546 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0637288077574987 0.0038621268649178 0.0 0.0002284148012791 0.1411873841109256 0.0 398 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +727965 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0095459266614567 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0967042147306326 0.0023576674662702 0.0 0.000638940520446 0.1983491427955255 0.0 2152 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +728132 CD48 CD2 CD48-CD2 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0095439179371716 0.7453966474499909 0.937587088419394 0.6198216015396206 0.006326966401379 0.0275738893167071 0.0 0.0 0.0 0.0 144 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +728311 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0095415561784055 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0065101973396288 0.0521374123931907 0.0 0.0001498800959232 0.0266649037010486 0.0 3336 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +728430 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0095402218454571 0.7797302331085993 0.7467524951532132 0.6198216015396206 0.0200499113739789 0.0104195741475089 0.0 0.0 0.0 0.0 137 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +728571 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.009538703237814 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0967042147306326 0.0026482500471321 0.0 0.0008907363420427 0.3323791681171867 0.0 1684 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +728612 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0095383205504807 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.011891719340537 0.0203874717835032 0.0 0.0002245065789473 0.0287169584622223 0.0 30400 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +728663 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0095377012855002 0.4601010570874773 0.8604147465201248 0.2461374514707439 0.0177188549930425 0.0436001007095475 0.0 0.0 0.0 0.0 222 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +728702 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0095373334469167 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.0037268694422441 0.0587195251380622 0.0 0.0001539679746612 0.0197972935581649 0.0 5683 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +728736 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0095368527380076 0.8023917560710954 0.6631822525600675 0.6198216015396206 0.0085367158000785 0.0267210109213584 0.0 0.0004656035385868 0.0489227245411449 0.0 1562 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +728843 VWF LRP1 VWF-LRP1 Pericytes B Cells Pericytes -> B Cells 0.0095355549668022 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.1263644540569636 0.0016667952436519 0.0 0.0030573847601128 0.3799974929692857 0.0 1063 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +728896 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0095349679814054 0.7835752212271604 0.6580560501976399 0.6198216015396206 0.0064863313435223 0.0362497659817488 0.0 0.0 0.0 0.0 32 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +729017 VEGFC FLT1 VEGFC-FLT1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0095334574022531 0.8718210606749883 0.878254460598671 0.9429656149619918 0.1796394187986057 0.0005788283879716 0.0 0.0003371544167228 0.3638820955681034 0.0 2966 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +729036 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0095332730560177 0.6213271600240247 0.62431395375366 0.8693461273411047 0.1153131738111426 0.0019304335593669 0.0 0.0016049382716049 0.3962478201289068 0.0 270 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +729118 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0095322454168093 0.6626993710110988 0.6207977546603366 0.8824495942126559 0.0035190936623492 0.0587195251380622 0.0 0.0003150566068919 0.0268508149723688 0.0 12101 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +729145 A2M LRP1 A2M-LRP1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0095319015740393 0.7741139100414175 0.6207977546603366 1.0 0.0149044683666724 0.0104714078116759 0.0 0.0003594663398076 0.0493399076729822 0.0 21212 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +729287 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Mast Cells Macrophages -> Mast Cells 0.0095302627643857 0.7487535481622718 0.7757991160529997 0.8567148457705164 0.0338862305197021 0.0044430418127202 0.0 0.0035812672176308 0.133871757579916 0.0 165 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +729388 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.009528869993368 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0272543760657653 0.0083242517891534 0.0 0.0021347971942665 0.2497418793974709 0.0 1093 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +730567 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0095153982609686 0.6561647292424944 0.6207977546603366 0.9161861017439124 0.1098969873322313 0.0018097844702233 0.0 0.0027173913043478 0.3666616686996237 0.0 460 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +731127 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0095090670733069 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0170183763647696 0.0144359394371152 0.0 0.0007788161993769 0.0727793795691009 0.0 2247 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +731218 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0095080227927638 0.9356727248601746 0.7470475610360806 0.7827641335561659 0.1750253929104546 0.0007714919761827 0.0 0.0013185654008438 0.2024655124955764 0.0 316 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +731414 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0095057948135263 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.293296467876477 0.00071798405859 0.0 0.0002115059221658 0.1601114321369164 0.0 394 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +731434 COL4A2 CD93 COL4A2-CD93 B Cells Macrophages B Cells -> Macrophages 0.0095055298377746 0.7783550150988336 0.944024288971064 0.6198216015396206 0.0033449520260795 0.0484215930647349 0.0 0.0008450704225352 0.0313144831978119 0.0 1065 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +731646 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Pericytes Macrophages -> Pericytes 0.0095031920238516 0.893316592628645 0.9003264838243337 0.8875000050982297 0.0007691101630988 0.1341680150528327 0.0 0.0004715710051199 0.0117427897855681 0.0 2474 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +731737 VWF ITGA9 VWF-ITGA9 Macrophages Macrophages Macrophages -> Macrophages 0.0095024306043669 0.9011206516381156 0.8794572885381431 1.0 0.0008850282134344 0.104965956217838 0.0 0.0003698498409645 0.0082892064310398 0.0 2458 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +732158 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0094973247275357 0.6332974881236617 0.8794572885381431 0.6198216015396206 0.0020251995753771 0.104965956217838 0.0 0.0001913875598086 0.0042894461910517 0.0 475 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +732172 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0094972228563997 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.1932385901170197 0.0096442330625583 0.0 0.0005376344086021 0.5473336042089121 0.0 155 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +732193 C3 LRP1 C3-LRP1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0094970074178165 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0691889863216023 0.0267255153180908 0.0 0.0074468085106382 1.0 0.0 752 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +732204 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0094968163992063 0.8937519114898692 0.7346293219749174 0.7204611100467462 0.0037268694422441 0.0416128058995347 0.0 0.0009509907997169 0.0564126571450095 0.0 1884 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +732241 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0094963435097962 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0085570823799139 0.046975263367762 0.0 0.0 0.0 0.0 157 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +732362 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0094949377599493 0.6605327397359113 0.885766439573873 0.6198216015396206 0.1468839381042521 0.0013756087909864 0.0 0.0 0.0 0.0 339 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +732379 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.009494656568985 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.1932385901170197 0.0011409783203169 0.0 0.0013422818791946 1.0 0.0 1490 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +732606 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0094921939124024 0.4601010570874773 0.6207977546603366 0.2461374514707439 0.0177188549930425 0.0587195251380622 0.0 0.0003360215053763 0.0286375561414274 0.0 186 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +732673 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0094916443892766 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0101610580570933 0.0218093597373452 0.0 0.0020570488206253 0.1114824482650096 0.0 3646 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +732717 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0094911524932294 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0069047442087267 0.0362497659817488 0.0 0.0 0.0 0.0 422 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +732862 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0094892624711325 0.6561647292424944 0.6207977546603366 0.8824495942126559 0.112230917768503 0.0018097844702233 0.0 0.0004402384914032 0.0594020373972047 0.0 12020 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +732970 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0094880256646153 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0135527119637784 0.0144359394371152 0.0 0.001 0.0934487233667255 0.0 3125 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +733028 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0094873249335219 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0411214967239829 0.0046263543438723 0.0 0.0002536231884057 0.0892198635199711 0.0 2300 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +733034 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0094872609530089 0.4629984640915818 0.9078204025796472 0.2461374514707439 0.0201301851612071 0.0350138403862125 0.0 0.0023361495135688 0.1000129750494123 0.0 1736 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +733411 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0094826729952497 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0015409900107563 0.1341680150528327 0.0 0.0013637249172024 0.0339586930794806 0.0 1711 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +733939 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0094762369348951 0.6605327397359113 0.7467524951532132 0.6198216015396206 0.0227314494836465 0.0104195741475089 0.0 0.0058275058275058 0.4020979020979021 0.0 143 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +733943 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0094761970901888 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.014525360548861 0.026308073552735 0.0 0.0005058168942842 0.0368659175407552 0.0 659 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +733961 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0094759691930523 0.4636527906642655 0.4630488285702799 1.0 0.014525360548861 0.0232163927704059 0.0 0.0005441020824948 0.106462253904727 0.0 22361 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +733995 CD34 SELP CD34-SELP CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0094756224838927 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.1173076386135379 0.002113171886167 0.0 0.0005977286312014 0.1731265317545817 0.0 1673 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +734385 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0094707999801813 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.4103175828613323 0.0009242223287825 0.0 0.0047995482778091 0.925826988235862 0.0 253 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +734405 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0094704603610058 0.7783550150988336 0.7461459456652184 0.6198216015396206 0.1928969878996252 0.0010390313650636 0.0 0.0007751937984496 0.1136767435484786 0.0 129 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +734442 THBS2 CD36 THBS2-CD36 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0094700998095507 0.7809827257946271 0.8587566561291643 0.7827641335561659 0.0004779710276932 0.287457858136305 0.0 0.0007497857754927 0.0228036243341784 0.0 389 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +734610 COL4A2 CD93 COL4A2-CD93 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0094680280857996 0.4630253981438691 0.944024288971064 0.7204611100467462 0.0047240947268779 0.0484215930647349 0.0 0.001780415430267 0.0659741337401972 0.0 337 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +734675 VWF ITGA9 VWF-ITGA9 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0094673787852328 0.6332974881236617 0.8794572885381431 0.6198216015396206 0.0019871862905238 0.104965956217838 0.0 0.000556699883093 0.0124769561589074 0.0 1633 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +734736 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0094665120175388 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0411127335336962 0.0049190726392343 0.0 0.0021685472496473 0.2648907203237197 0.0 1418 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +734939 CD48 CD2 CD48-CD2 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0094642150162254 0.6659645551150886 0.6614977577544194 0.8824495942126559 0.0081474500750471 0.0226890201466244 0.0 8.602890571231934e-05 0.012469036876347 0.0 5812 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +735176 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0094609465141995 0.6582846571368821 0.8347945881127203 0.6198216015396206 0.1740454925211078 0.0012097093680331 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +735269 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0094597904277605 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0028649117803088 0.1370986982961073 0.0 0.0014164305949008 0.0456300425487124 0.0 1412 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +735572 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0094565391049931 0.9184503888425788 0.8818326005152037 0.9429656149619918 0.0004696576149175 0.1993723722552783 0.0 0.0002460024600246 0.0091142005861678 0.0 2710 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +735715 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0094551478686532 0.4629984640915818 0.6207977546603366 0.2461374514707439 0.0201301851612071 0.0501711964086628 0.0 0.0035725202506495 0.0606153395345738 0.0 727 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +735987 CD48 CD2 CD48-CD2 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.009451782927177 0.9426443637490616 0.4603649459881741 0.2461374514707439 0.0632786830726401 0.0105486447632276 0.0 0.0047393364928909 0.8802845495444287 0.0 211 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +736018 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0094513265327764 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0002750231449378 1.0 0.0 0.0008351816862455 0.014316946121211 0.0 1739 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +736023 CD48 CD2 CD48-CD2 B Cells Pericytes B Cells -> Pericytes 0.0094512909788322 0.9426443637490616 0.7763428264267787 0.6198216015396206 0.0632786830726401 0.0024832440877005 0.0 0.0008257638315441 0.2111024409980671 0.0 1211 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +736512 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0094455583243836 0.9468422434493456 0.2491545808994955 0.2461374514707439 0.1120119983652299 0.0109188419829382 0.0 0.000785751702462 0.1131114754803683 0.0 1909 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +736616 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0094442954689071 0.9468422434493456 0.9003264838243337 0.9429656149619918 0.1120119983652299 0.0007880862995141 0.0 0.0012362328613171 0.8255036344270054 0.0 2966 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +736646 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0094439358221693 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0012306151710811 0.1973932010691654 0.0 0.0040935672514619 0.0732655446547776 0.0 285 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +736854 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0094414807581178 0.6249837837987587 0.7746834992804791 1.0 0.0161757332769496 0.0090444648829713 0.0 0.0003531953793733 0.049694617726874 0.0 4011 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +737031 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.009439202331085 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.1496557267835524 0.0014748371602574 0.0 0.0 0.0 0.0 42 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +737056 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0094388635467733 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.002196330917593 0.0826982152707935 0.0 0.0009293680297397 0.0344950064389668 0.0 2152 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +737214 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0094367800913969 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0020251995753771 0.1112417752963437 0.0 9.627331995535325e-05 0.0104065246006397 0.0 30217 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +737438 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0094340566917628 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0272543760657653 0.0073658308476012 0.0 0.0028603658045282 0.5207996853656283 0.0 591 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +737458 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0094338798461138 0.7158082793127664 0.863034163938375 0.7204611100467462 0.0025256125075084 0.0627102121186242 0.0 0.0023923444976076 0.0192173335223749 0.0 38 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +738125 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0094255395597919 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0002705513462707 1.0 0.0 0.0086872586872586 0.1489197100640724 0.0 148 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +738347 VEGFC FLT1 VEGFC-FLT1 B Cells Pericytes B Cells -> Pericytes 0.0094226800014879 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0012459853895406 0.1332188634280341 0.0 0.0008257638315441 0.0311231684656004 0.0 1211 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +738366 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Pericytes B Cells -> Pericytes 0.0094224440826047 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0002327631000826 0.8672894033034337 0.0 0.0013762730525736 0.0144108201118095 0.0 1211 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +738433 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0094217164568876 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0131092554497256 0.0215025911544899 0.0 0.0011580775911986 0.1391264317573096 0.0 1884 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +738490 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0094209693905015 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0101610580570933 0.0265498740402422 0.0 0.0040564373897707 0.1030537494318364 0.0 135 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +738563 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0094200236086413 0.8818165186409654 0.9078204025796472 0.9429656149619918 0.0026436039558049 0.0350138403862125 0.0 0.0004618120295559 0.0197706502607107 0.0 3218 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +738661 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0094186330789816 0.6630837220165452 0.944024288971064 0.6198216015396206 0.0037159398684439 0.0484215930647349 0.0 0.0012004801920768 0.0406790049595556 0.0 119 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +738905 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0094158029699494 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.1194227711616854 0.0032187363284526 0.0 0.0002988643156007 0.0588703212956376 0.0 1673 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +738965 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0094149398006531 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0085570823799139 0.0446401662952339 0.0 0.0009337068160597 0.0844989498460549 0.0 714 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +739051 C3 LRP1 C3-LRP1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0094139150438555 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.005043231651446 0.0501711964086628 0.0 0.0020190895741556 0.0580953879503944 0.0 1362 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +739191 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0094125452458737 0.7160288858520609 0.4641352222874551 0.2461374514707439 0.0186793449598515 0.0455121851821151 0.0 0.0003477051460361 0.0254568995071982 0.0 5752 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +739627 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.009407249390557 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.00146889578236 0.1341680150528327 0.0 0.002230093139184 0.0555324959578823 0.0 2541 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +739641 VWF ITGA9 VWF-ITGA9 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0094070250519253 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0019871862905238 0.1112417752963437 0.0 6.91323885240235e-05 0.0074727650631542 0.0 3945 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +739707 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0094060749778772 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0065101973396288 0.026308073552735 0.0 0.0020325203252032 0.1481380467034007 0.0 246 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +739857 CD48 CD2 CD48-CD2 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0094042660772791 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0161888123016941 0.0226890201466244 0.0 0.0 0.0 0.0 5095 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +739989 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0094026611239925 0.4625081978296446 0.7763400818577846 0.6198216015396206 0.0141498126994191 0.0219439768073448 0.0 0.0 0.0 0.0 126 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +740287 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0093989880802566 0.7487535481622718 0.7757991160529997 0.9429656149619918 0.1027229557481577 0.0012252690191386 0.0 0.0005137107631261 0.4121870783746612 0.0 2566 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +740357 MMRN2 CD93 MMRN2-CD93 Macrophages Pericytes Macrophages -> Pericytes 0.0093982688848614 0.893316592628645 0.8817184225858201 0.8875000050982297 0.0007691101630988 0.1281708518900828 0.0 0.0009094583670169 0.0187829761917202 0.0 2474 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +740861 C1QB LRP1 C1QB-LRP1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0093921553665305 0.7753420160918723 0.9078204025796472 0.9429656149619918 0.0161519521398178 0.0064028969591119 0.0 0.0005358534684333 0.0550864361264192 0.0 2566 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +741148 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0093890819432376 0.6630837220165452 0.6587114738285964 0.8824495942126559 0.0415873844357376 0.0042738820064046 0.0 0.0003670061473529 0.0265248644954185 0.0 4671 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +741264 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.009387880100075 0.7745997874735252 0.4630488285702799 0.2461374514707439 0.0215813276111062 0.0359289752254096 0.0 0.0 0.0 0.0 877 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +741278 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.009387728847557 0.8023917560710954 0.7754239189773715 0.7204611100467462 0.0085367158000785 0.0178869147172998 0.0 0.0001416029453412 0.0242072273170784 0.0 2247 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +741369 CCN1 CAV1 CCN1-CAV1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0093865467268811 0.6213271600240247 0.62431395375366 1.0 0.013905026986541 0.0126805820762719 0.0 0.0002482871330693 0.0505824412119307 0.0 21212 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +741549 VWF LRP1 VWF-LRP1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0093845052059944 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.00023686843287 1.0 0.0 0.0008980803879262 0.0068950217185528 0.0 4087 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +742099 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0093780477224335 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0084812136822336 0.0446401662952339 0.0 0.0027593818984547 0.3113914016871261 0.0 453 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +742106 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0093779764033906 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0015409900107563 0.1281708518900828 0.0 0.0011689070718877 0.0241413510478944 0.0 1711 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +742138 C1QB LRP1 C1QB-LRP1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0093775920905805 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0111808254589153 0.0203874717835032 0.0 0.000313126252505 0.0177324694781075 0.0 1996 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +742142 A2M LRP1 A2M-LRP1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0093775520648411 0.7741139100414175 0.6207977546603366 0.909150863993142 0.093381536992618 0.0016667952436519 0.0 0.0008216709075487 0.1649978121223518 0.0 1572 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +742190 A2M LRP1 A2M-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0093770493709636 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2100317344087863 0.0018097844702233 0.0 0.0040481832543443 0.5462274148242419 0.0 422 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +742332 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0093754788114622 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0272543760657653 0.0070956399217802 0.0 0.0038470074720722 0.4828130687911747 0.0 1931 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +742536 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0093729719055728 0.6160088550075702 0.4600037439857229 0.2461374514707439 0.0548063857429699 0.017738069381683 0.0 0.0023460410557184 0.5848917290620239 0.0 155 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +742627 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0093717716003506 0.8023917560710954 0.4600037439857229 1.0 0.0085367158000785 0.0215025911544899 0.0 0.0007887108642888 0.0947523111324212 0.0 22361 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +742782 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0093699356153086 0.8730912658940219 0.8622452992050237 0.6198216015396206 0.0057086106530109 0.0254056950469408 0.0 0.0021645021645021 0.3401094356581942 0.0 126 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +742886 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0093686531893169 0.6342079770588467 0.6580560501976399 0.9161861017439124 0.000895875398841 0.1973932010691654 0.0 0.002859477124183 0.0511781378103225 0.0 408 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +743018 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0093669685208521 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0131302879503246 0.0144359394371152 0.0 0.0002631776825325 0.023247747366616 0.0 4836 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +743281 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0093642936518494 0.8949858186325867 0.7754072541855492 0.6198216015396206 0.001895566065636 0.0826982152707935 0.0 0.0016835016835016 0.0624859039197447 0.0 594 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +743353 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0093634730293397 0.7800321422220979 0.7841656220878274 0.6198216015396206 0.1357656553382984 0.001309307002134 0.0 0.0087209302325581 1.0 0.0 129 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +743475 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0093620744855043 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0106922602624424 0.0176963220730796 0.0 0.0011297182349813 0.1496295523451172 0.0 1881 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +743896 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0093573270359819 0.8730912658940219 0.4600037439857229 1.0 0.0057086106530109 0.0292791515533623 0.0 0.0069065210407966 0.1630793619427674 0.0 283 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +743989 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0093563236238837 0.8630183004227985 0.8891607331132086 0.8693461273411047 0.0016575843792215 0.0606680526002441 0.0 0.0016637980493402 0.0550234293246015 0.0 1245 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +744162 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0093541518453687 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0338862305197021 0.0064230792457803 0.0 0.000352360817477 0.0473924249783213 0.0 129 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +744783 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0093464600852343 0.7797302331085993 0.885766439573873 0.6198216015396206 0.1132020978253244 0.0013756087909864 0.0 0.0016268980477223 0.6130004145615544 0.0 922 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +744808 CXCL12 ITGA4 CXCL12-ITGA4 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0093461949022086 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0052742025956585 0.0390724515618796 0.0 0.0004562564161058 0.2577936056354163 0.0 797 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +744836 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0093459334995927 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0053032910137447 0.0689186266365139 0.0 0.0008333333333333 0.0783696574654063 0.0 800 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +745607 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0093365103504251 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0255753403203798 0.0080072638027924 0.0 0.0012689393939393 0.3065133968421571 0.0 2400 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +745641 COL4A2 CD93 COL4A2-CD93 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0093360575623953 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.0047240947268779 0.0627790816848129 0.0 0.0040590405904059 0.0890205635471545 0.0 271 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +745652 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0093359406206995 0.6342079770588467 0.896164124004365 0.6198216015396206 0.002196330917593 0.0855781119790033 0.0 0.0011806375442739 0.0594922591234291 0.0 2541 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +745974 VWF LRP1 VWF-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0093323528304025 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0036144684673052 0.0587195251380622 0.0 0.0001755754974639 0.018259285911229 0.0 1165 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +746161 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0093300156155009 0.831981591331937 0.657421674383923 0.6198216015396206 0.0048935684578858 0.0397596998227057 0.0 0.0 0.0 0.0 10 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +746365 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0093277080510266 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0526353932596327 0.0032875740549697 0.0 0.0066280566280566 1.0 0.0 370 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +746429 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0093268752903059 0.4630253981438691 0.7461459456652184 0.7204611100467462 0.2545335314555431 0.0010390313650636 0.0 0.0 0.0 0.0 51 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +746583 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0093250745296526 0.7487535481622718 0.7757991160529997 0.9429656149619918 0.0131092554497256 0.0091569531245039 0.0 0.0006073789479631 0.1589790974676712 0.0 3218 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +746646 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0093243049811137 0.4604235282221027 0.944024288971064 0.2461374514707439 0.0126864732057784 0.0484215930647349 0.0 0.0009652509652509 0.0327081188526157 0.0 222 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +746649 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0093242412064301 0.4630253981438691 0.4630027772793905 0.2461374514707439 0.2545335314555431 0.0048929293424311 0.0 0.0007254290171606 0.2345624821640022 0.0 12820 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +747106 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0093189534978076 0.7487535481622718 0.4596166826058663 0.2461374514707439 0.1027229557481577 0.0075270071967493 0.0 0.0006790799561883 0.2997691074594474 0.0 2075 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +747254 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0093169399183513 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0616816618657801 0.0267255153180908 0.0 0.0006451612903225 0.1021454681307394 0.0 155 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +747255 A2M LRP1 A2M-LRP1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0093169374010501 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.0021905373114471 0.166956519448744 0.0 0.0038011695906432 0.037065119069784 0.0 285 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +747483 COL4A1 CD93 COL4A1-CD93 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0093145283627417 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0168149984327668 0.0155837683010033 0.0 0.000513874614594 0.1210856442034438 0.0 3336 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +747603 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0093130061229718 0.7205550478301406 0.4630027772793905 0.8293805866303694 0.0151307911035231 0.0155837683010033 0.0 0.0001736834792274 0.023620396250297 0.0 7197 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +747672 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0093122598903546 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0149256517769723 0.0147571931436988 0.0 0.0069235400361228 0.1386511872379158 0.0 151 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +747895 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0093098268392072 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0001959417442809 1.0 0.0 0.0009541984732824 0.0137007741187653 0.0 262 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +747988 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0093086334673659 0.7797302331085993 0.4642836810638544 0.6198216015396206 0.0200499113739789 0.0144613249009303 0.0 0.0022446689113355 0.0130083839034257 0.0 297 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +748420 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0093033855379858 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.00146889578236 0.1281708518900828 0.0 0.0013774104683195 0.0284475562279252 0.0 2541 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +748457 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0093030013278001 0.7789175740361626 0.6207977546603366 0.8693461273411047 0.0075637985935472 0.0203874717835032 0.0 0.0009817045961624 0.0306675770218469 0.0 1245 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +748471 VWF LRP1 VWF-LRP1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0093028426915653 0.6332974881236617 0.6207977546603366 0.909150863993142 0.0036144684673052 0.0501711964086628 0.0 0.0006545328370449 0.0132691035048983 0.0 5764 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +748712 THBS2 CD36 THBS2-CD36 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0092998454686493 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.004981832968137 0.0455125113141721 0.0 0.0004871103117505 0.1107626925950873 0.0 3336 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +748734 COL4A1 CD93 COL4A1-CD93 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0092995250246127 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.0017253404164066 0.1281708518900828 0.0 0.0018963337547408 0.0446831500964244 0.0 452 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +748901 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0092975591872868 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0039530346951707 0.0501711964086628 0.0 0.0045336787564766 0.1079833436173975 0.0 193 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +748965 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0092966610711711 0.7296454584598743 0.4638256179742202 0.8293805866303694 0.0051524613572059 0.0446401662952339 0.0 0.0025720164609053 0.290247541078741 0.0 324 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +749022 C1QB LRP1 C1QB-LRP1 B Cells Pericytes B Cells -> Pericytes 0.0092959207042977 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.0037630364713574 0.0350138403862125 0.0 0.0007741535920726 0.0272158147275254 0.0 1211 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +749180 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0092942924107902 0.8840293712888387 0.6587114738285964 0.6198216015396206 0.0061698665784747 0.0289462771086338 0.0 0.0001583670596515 0.033716105272471 0.0 5683 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +749290 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0092930573497872 0.4636527906642655 0.777821334064334 0.2461374514707439 0.0666348171285698 0.0108892901157311 0.0 0.0006877579092159 0.0853433076104985 0.0 727 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +749338 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0092924633770233 0.7789175740361626 0.2550748532138862 0.2461374514707439 0.0492631209980634 0.0267255153180908 0.0 0.0009185354111237 0.0549076312636739 0.0 877 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +749381 MMRN2 CD93 MMRN2-CD93 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0092919092762343 0.9468422434493456 0.7461459456652184 0.7827641335561659 0.1120119983652299 0.0010390313650636 0.0 0.0047468354430379 0.5512339806368575 0.0 316 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +749480 CD34 SELP CD34-SELP Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0092908224854134 0.633566764858408 0.7760344326192508 0.909150863993142 0.0042829523358709 0.0335947364052305 0.0 0.0003377807802736 0.0284123378008775 0.0 5921 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +749505 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0092904971845359 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.0037268694422441 0.0501711964086628 0.0 0.0013622698233746 0.0366150197828359 0.0 887 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +749518 A2M LRP1 A2M-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.009290398561401 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.093381536992618 0.0018097844702233 0.0 0.0031897926634768 0.4304034898930192 0.0 209 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +749626 C3 LRP1 C3-LRP1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0092890167020429 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0091898156146168 0.0203874717835032 0.0 0.000187875751503 0.0240314567941255 0.0 1996 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +749682 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0092882549597832 0.633566764858408 0.7478729882108823 0.6198216015396206 0.0799339500711946 0.0027351735586246 0.0 0.0 0.0 0.0 756 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +749875 VWF ITGA9 VWF-ITGA9 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.009286193236565 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0036144684673052 0.0565946652887153 0.0 0.0004166666666666 0.0154126129681011 0.0 2400 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +749919 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0092855850902853 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0186793449598515 0.009971631136135 0.0 0.0 0.0 0.0 3646 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +750263 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0092816842257349 0.6303642896310324 0.6331674633943454 0.8693461273411047 0.0104129581710415 0.0176963220730796 0.0 0.0003478260869565 0.0460690640141038 0.0 575 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +750360 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0092804268070353 0.6582846571368821 0.4630027772793905 0.2461374514707439 0.1740454925211078 0.0048929293424311 0.0 0.0027173913043478 0.8786497841697376 0.0 184 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +750496 C3 LRP1 C3-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.009278857816343 0.6319926036888139 0.6207977546603366 0.9161861017439124 0.0616816618657801 0.0028784826949613 0.0 0.0008555133079847 0.221346422765875 0.0 526 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +750574 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0092779304379615 0.4601010570874773 0.9078204025796472 0.2461374514707439 0.0177188549930425 0.0350138403862125 0.0 0.0005760368663594 0.0202509073026318 0.0 1736 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +751086 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0092715246273293 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0053032910137447 0.0362497659817488 0.0 0.0007165376898824 0.0300511403451226 0.0 1163 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +751209 VWF ITGA9 VWF-ITGA9 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0092698209781092 0.6332974881236617 0.6252253442669611 0.909150863993142 0.0036144684673052 0.0487643047611538 0.0 0.0002050343826887 0.0080256305250457 0.0 5764 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +751311 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0092686692140438 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0435116250366991 0.0042655619249233 0.0 0.0002659574468085 0.0673506016146296 0.0 1880 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +751388 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0092676997167887 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0073929685753755 0.046975263367762 0.0 0.0005515212795293 0.0912433197735882 0.0 10879 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +751599 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0092649984170116 0.2542249848376565 0.62431395375366 0.2461374514707439 0.1711385759005754 0.009460730808256 0.0 0.0020632737276478 0.2561678782576334 0.0 727 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +751647 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0092642903539602 0.633566764858408 0.941479368642921 0.6198216015396206 0.0799339500711946 0.0021392900294222 0.0 0.0 0.0 0.0 1351 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +751845 THBS2 CD36 THBS2-CD36 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0092617455987018 0.6242573126045354 0.6176321640000088 0.909150863993142 0.0063387366560491 0.0284069116891947 0.0 0.00036866759195 0.0305383517303481 0.0 5764 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +752176 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0092581396734928 0.7487535481622718 0.7462743270426613 0.7827641335561659 0.0637288077574987 0.0022591041672132 0.0 0.0030207134637514 0.3356573707484784 0.0 316 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +752387 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0092553253305996 0.6332974881236617 0.6252253442669611 0.8824495942126559 0.0016171311116606 0.1112417752963437 0.0 0.0001720578114246 0.0185983390637519 0.0 5812 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +752433 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0092547498143629 0.7840818683779507 0.6580560501976399 0.6198216015396206 0.0032417203409647 0.0606066271159369 0.0 0.0055555555555555 0.1573019719894779 0.0 30 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +752596 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0092526459754467 0.8913986641324685 0.6331674633943454 0.6198216015396206 0.0054950348959687 0.0326412663903893 0.0 0.0001078205865439 0.0367277412810912 0.0 1739 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +752849 CD34 SELP CD34-SELP T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0092494569028626 0.633566764858408 0.4623922682986163 0.6198216015396206 0.015517736049123 0.0222228052993653 0.0 0.0001838404265097 0.0491246392471308 0.0 10879 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +752870 A2M LRP1 A2M-LRP1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0092492986547538 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.2100317344087863 0.0016667952436519 0.0 0.0014805414551607 0.2973040649409463 0.0 394 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +753047 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.009246907949576 0.8730912658940219 0.4600037439857229 0.8767341187813953 0.0057086106530109 0.0310998965832685 0.0 0.0016697588126159 0.315105424082537 0.0 2450 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +753100 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.009246201787106 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.0227314494836465 0.0144613249009303 0.0 0.0019762845849802 0.0114530336541031 0.0 253 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +753514 C3 LRP1 C3-LRP1 B Cells Macrophages B Cells -> Macrophages 0.009240905704582 0.6319926036888139 0.8604147465201248 0.6198216015396206 0.0042375227960614 0.0436001007095475 0.0 0.002206572769953 0.0630842622660485 0.0 1065 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +753578 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0092401941810025 0.4629984640915818 0.7346293219749174 0.8293805866303694 0.0683610513379333 0.0032275631628407 0.0 0.0048833079654997 0.2685068705400358 0.0 219 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +753892 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0092363071338891 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.454846709299195 0.0007261054236978 0.0 0.0 0.0 0.0 135 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +753920 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0092360853301197 0.6589792304505506 0.2550748532138862 0.2461374514707439 0.0561415215593491 0.0267255153180908 0.0 0.0006038647342995 0.0360974457408111 0.0 184 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +753951 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0092358252014956 0.633566764858408 0.6572093097629401 0.8824495942126559 0.0799339500711946 0.002113171886167 0.0 0.0 0.0 0.0 4671 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +753963 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0092357056371179 0.7745997874735252 0.777821334064334 0.8693461273411047 0.0065101973396288 0.0182001711419816 0.0 0.0012048192771084 0.1443041800753907 0.0 1245 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +753966 C1QB LRP1 C1QB-LRP1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0092356684997162 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.0037630364713574 0.0416128058995347 0.0 0.0005040322580645 0.0199691869341591 0.0 496 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +753981 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0092355694675359 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0151307911035231 0.0118035014556376 0.0 0.0006861848124428 0.052571850510962 0.0 1093 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +754257 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0092320965766401 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.000895875398841 0.1993723722552783 0.0 0.0 0.0 0.0 262 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +754354 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0092310244749407 0.6160088550075702 0.8622452992050237 0.8693461273411047 0.0052742025956585 0.0254056950469408 0.0 0.0005050505050505 0.0793588683202453 0.0 360 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +754373 C3 LRP1 C3-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0092307610083122 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0691889863216023 0.0028784826949613 0.0 0.0042682926829268 1.0 0.0 246 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +754497 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0092291463216267 0.7451589345683471 0.6331674633943454 0.6198216015396206 0.0040724665904272 0.0518891167572028 0.0 0.0003676470588235 0.0188166722372598 0.0 170 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +754542 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0092287126129142 0.9097736029185508 0.773263018678637 0.6198216015396206 0.0430965463818576 0.0032875740549697 0.0 0.0021811325002814 0.3519366003269466 0.0 1692 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +754590 CD48 CD2 CD48-CD2 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0092281637028505 0.4593282471594782 0.4603649459881741 1.0 0.0467114894617178 0.0062523288579129 0.0 0.0017667844522968 0.0208821022937535 0.0 283 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +755179 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0092210143770681 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0071496754272206 0.0309945332907452 0.0 0.0002585315408479 0.0161269082166215 0.0 11604 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +755228 CD34 SELP CD34-SELP Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0092204663964887 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.0018206581062216 0.0741032966028748 0.0 0.0 0.0 0.0 452 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +755377 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0092183213534525 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.2545335314555431 0.001079730675535 0.0 0.0022842639593908 0.3863040790809242 0.0 394 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +755430 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0092177948386355 0.4601010570874773 0.7346293219749174 0.2461374514707439 0.0177188549930425 0.0416128058995347 0.0 0.000668874419997 0.0265000466035406 0.0 13362 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +755517 C1QB LRP1 C1QB-LRP1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0092166189807006 0.8703788833238396 0.2550748532138862 0.2461374514707439 0.0419710388788557 0.0267255153180908 0.0 0.0014686684073107 0.0913648510669837 0.0 383 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +755592 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.0092159027076219 0.7205550478301406 0.4630027772793905 1.0 0.0117842887908422 0.0155837683010033 0.0 0.0001527537819729 0.0207740245357896 0.0 94924 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +755781 CD48 CD2 CD48-CD2 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0092133765899993 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0467114894617178 0.0050968401714881 0.0 0.0027985074626865 0.7122030495674205 0.0 536 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +755827 CD48 CD2 CD48-CD2 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.009212931683853 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0212837736082081 0.0112209532878862 0.0 0.0003075661267172 0.0604312363914272 0.0 9754 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +755892 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0092123005788926 0.6342079770588467 0.836885603004631 0.6198216015396206 0.0673400749834054 0.0027591088867233 0.0 0.0 0.0 0.0 42 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +756049 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0092103932116285 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.011891719340537 0.0144359394371152 0.0 8.788254755996693e-05 0.0150081152822044 0.0 4836 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +756304 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0092070056101885 0.6626993710110988 0.8604147465201248 0.6198216015396206 0.0039530346951707 0.0436001007095475 0.0 0.002626050420168 0.0615658699947271 0.0 119 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +756456 C1QB LRP1 C1QB-LRP1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0092050858444125 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0012213774841743 0.166956519448744 0.0 0.0008680555555555 0.0091976114471311 0.0 144 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +756555 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0092041041841588 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0411127335336962 0.0041555861088636 0.0 0.0015970515970515 0.3034372656764807 0.0 407 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +756583 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0092038427769541 0.4625081978296446 0.885766439573873 0.7204611100467462 0.149715856631667 0.0013756087909864 0.0 0.0002469135802469 0.0930347954281075 0.0 11475 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +756696 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.009202509181015 0.662063103571249 0.6331674633943454 0.9161861017439124 0.0491302556793708 0.0032187363284526 0.0 0.0008187772925764 0.1612828289207451 0.0 458 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +757008 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.00919901292421 0.8516956437178343 0.8818326005152037 0.8567148457705164 0.000472352586488 0.1993723722552783 0.0 0.0030193236714975 0.111863603208854 0.0 276 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +757086 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0091981149251759 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0265972645862203 0.0064028969591119 0.0 0.0002705139765554 0.0512499635092511 0.0 1109 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +757154 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0091973003208673 0.6332974881236617 0.6252253442669611 0.8824495942126559 0.0015572459193676 0.1112417752963437 0.0 0.00015025054278 0.016241114053463 0.0 12101 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +757230 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.009196499486983 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0020491452254277 0.088850508457521 0.0 0.0 0.0 0.0 475 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +757331 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0091952637435123 0.7789175740361626 0.6207977546603366 0.8693461273411047 0.0070532058552773 0.0203874717835032 0.0 0.0007914970601537 0.0247256630453987 0.0 737 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +757567 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0091922154737621 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.112230917768503 0.0016667952436519 0.0 0.0010964912280701 0.2201838375690467 0.0 570 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +757788 CD48 CD2 CD48-CD2 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0091895157814672 0.7453966474499909 0.8960994285623033 0.6198216015396206 0.006326966401379 0.0229905310518441 0.0 0.0029411764705882 0.1386678102273603 0.0 170 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +757894 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0091882559675822 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0073929685753755 0.0446401662952339 0.0 0.000130412102243 0.011802083370517 0.0 1278 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +758225 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0091846799691719 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.0024635726452692 0.0627790816848129 0.0 0.0 0.0 0.0 209 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +758271 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0091841042059798 0.7745997874735252 0.8998347793593909 0.6198216015396206 0.0215813276111062 0.0064362797035136 0.0 0.0003508771929824 0.1271308851879515 0.0 475 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +758367 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0091830856434041 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.0693389464442948 0.0045642085393754 0.0 0.0 0.0 0.0 135 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +758480 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0091818033216701 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0411214967239829 0.0042655619249233 0.0 0.0007270693512304 0.1841217789106877 0.0 1490 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +759075 VWF SELP VWF-SELP T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0091755962892434 0.6332974881236617 0.7760344326192508 1.0 0.0036144684673052 0.0335947364052305 0.0 0.0003835736204206 0.0205193128626028 0.0 21212 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +759346 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0091724664007128 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0073929685753755 0.0244129856070659 0.0 0.0 0.0 0.0 97 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +759458 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0091712429512532 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0083898580598364 0.0312252462757311 0.0 0.004241601628775 0.2310143107988695 0.0 1684 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +759598 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0091696266977493 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.2159908053119969 0.00071798405859 0.0 0.000438596491228 0.3320205487470795 0.0 570 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +760253 MMRN2 CD93 MMRN2-CD93 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0091617596617374 0.9468422434493456 0.4630027772793905 0.2461374514707439 0.1120119983652299 0.0048929293424311 0.0 0.001964379256155 0.4039946995895417 0.0 1909 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +760344 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.009160596025887 0.4636527906642655 0.777821334064334 0.6198216015396206 0.014525360548861 0.0182001711419816 0.0 0.0001939393939393 0.0232286001381962 0.0 6875 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +760385 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0091600759576871 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.1098969873322313 0.0016667952436519 0.0 0.0009996364958197 0.2007346654391745 0.0 917 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +760451 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0091593578100468 0.6659645551150886 0.7464347811605867 0.6198216015396206 0.1496557267835524 0.0012805120781881 0.0 0.0039682539682539 0.9632574645782744 0.0 756 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +760765 CD48 CD2 CD48-CD2 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0091560233953759 0.4593282471594782 0.4603649459881741 0.8293805866303694 0.0467114894617178 0.0071918009517169 0.0 0.0030864197530864 0.7543603415284204 0.0 324 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +760859 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0091549544973868 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0208904415011529 0.0155837683010033 0.0 0.0003170577045022 0.0431188311511446 0.0 1577 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +760998 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0091533321238241 0.8721681415062816 0.7467524951532132 0.7827641335561659 0.0110717612136884 0.0104195741475089 0.0 0.0021097046413502 0.1455696202531645 0.0 316 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +761227 A2M LRP1 A2M-LRP1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0091506998033174 0.919551140852988 0.7346293219749174 0.7204611100467462 0.037376181609614 0.0032275631628407 0.0 0.0053680981595092 0.3170186936287366 0.0 326 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +761478 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0091477498149158 0.6332974881236617 0.8794572885381431 0.6198216015396206 0.0016171311116606 0.104965956217838 0.0 0.000935141273128 0.0209587194492978 0.0 1361 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +761608 C3 LRP1 C3-LRP1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0091462986990754 0.2485046029682279 0.7346293219749174 0.2461374514707439 0.0013028322726017 1.0 0.0 0.0120786516853932 0.2139758397844022 0.0 89 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +761611 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0091461863353289 0.7840818683779507 0.4638256179742202 0.7204611100467462 0.0032417203409647 0.0689186266365139 0.0 0.0007680491551459 0.0722300990464574 0.0 1302 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +761930 C1QB LRP1 C1QB-LRP1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0091427978008118 0.7452691992612583 0.6207977546603366 0.6198216015396206 0.0012199377895337 0.166956519448744 0.0 0.0 0.0 0.0 160 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +762009 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0091417975812933 0.8640667164982425 0.930308383061206 0.9429656149619918 0.1882781599600688 0.0004089864655001 0.0 0.0002528658125421 0.3250106869745574 0.0 2966 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +762084 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0091409962277758 0.6589792304505506 0.6207977546603366 0.8824495942126559 0.0561415215593491 0.0028784826949613 0.0 0.0003662007198459 0.0270771095291326 0.0 11947 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +762121 CD34 SELP CD34-SELP Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0091405050256481 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0042829523358709 0.04130664769978 0.0 0.0 0.0 0.0 3945 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +762123 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0091404505338972 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0215813276111062 0.0066828239855783 0.0 0.0005356186395286 0.0659751804706415 0.0 1867 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +762171 VWF ITGA9 VWF-ITGA9 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0091400208881769 0.9011206516381156 0.6252253442669611 0.6198216015396206 0.0008850282134344 0.1886404570313 0.0 0.0004591368227731 0.0120079117855228 0.0 594 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +762178 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0091399223243218 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.0198024073017111 0.0155837683010033 0.0 0.0006369426751592 0.1760802406573089 0.0 157 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +762651 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0091343688634073 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0106340017102282 0.0310998965832685 0.0 0.0002882342768201 0.0543935946594952 0.0 1577 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +762654 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0091343532130172 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0186793449598515 0.0090444648829713 0.0 9.1424392027793e-05 0.0103831505773631 0.0 3646 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +762727 CD34 SELP CD34-SELP Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0091335468688942 0.8963354148873306 0.6572093097629401 0.6198216015396206 0.0038492365148421 0.04130664769978 0.0 0.0 0.0 0.0 1739 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +762912 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0091313736987567 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0012306151710811 0.1615138601457002 0.0 0.0 0.0 0.0 148 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +763199 HSPG2 LRP1 HSPG2-LRP1 Macrophages Pericytes Macrophages -> Pericytes 0.0091281263434603 0.9253089325030373 0.9078204025796472 0.8875000050982297 0.0022161183602947 0.0350138403862125 0.0 0.0008982304859426 0.0384541754101903 0.0 2474 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +763531 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0091242368556276 0.7296454584598743 0.8341464445360613 0.7204611100467462 0.7029371915698084 0.0001871866311057 0.0 0.0004621072088724 0.0586654995646648 0.0 1082 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +763536 CD48 CD2 CD48-CD2 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0091241970789234 0.7719609236370527 0.7763428264267787 0.8875000050982297 0.0212837736082081 0.0050968401714881 0.0 0.0003584229390681 0.0912164479254808 0.0 2790 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +763593 A2M LRP1 A2M-LRP1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0091234079575284 0.919551140852988 0.2550748532138862 0.2461374514707439 0.037376181609614 0.0267255153180908 0.0 0.0022179974651457 0.192937861035235 0.0 263 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +763723 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0091215180066358 0.831981591331937 0.7763400818577846 0.6198216015396206 0.0048935684578858 0.0293997450046583 0.0 0.0030864197530864 0.190290708356888 0.0 162 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +763924 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0091191076163776 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0035190936623492 0.0501711964086628 0.0 0.0053827751196172 0.1282071550672724 0.0 209 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +764210 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0091155185957298 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0028649117803088 0.0606066271159369 0.0 0.0 0.0 0.0 246 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +764236 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0091153331061598 0.6626993710110988 0.2550748532138862 0.2461374514707439 0.0515877972474039 0.0267255153180908 0.0 0.0 0.0 0.0 184 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +764566 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0091113689151324 0.4625081978296446 0.8381155706134242 0.7204611100467462 0.0704104148800194 0.0029095741067474 0.0 0.0087719298245614 0.2770696185258899 0.0 38 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +764812 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.00910827676057 0.4625081978296446 0.9130058539314824 0.7204611100467462 0.0141498126994191 0.0132636308162813 0.0 0.0024727992087042 0.3210103816256444 0.0 337 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +764818 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0091082119015245 0.6605327397359113 0.7467524951532132 0.6198216015396206 0.0179229861158654 0.0104195741475089 0.0 0.0 0.0 0.0 21 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +764840 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0091080612444296 0.6160088550075702 0.6631822525600675 0.9161861017439124 0.0548063857429699 0.0027830389352876 0.0 0.0034584980237154 1.0 0.0 460 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +764998 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0091062007930294 0.6301823358791634 0.944024288971064 0.6198216015396206 0.0031934983073077 0.0484215930647349 0.0 0.0012351060738157 0.0276350234669128 0.0 3441 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +765213 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0091037021414358 0.6303682835571691 0.663300745568453 0.6198216015396206 0.000219642761279 1.0 0.0 0.000871437788559 0.0149384595858095 0.0 5683 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +765365 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0091018038480667 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.1928969878996252 0.0007261054236978 0.0 0.0001719690455717 0.0264103013992001 0.0 1163 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +765550 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0090998855248784 0.6303642896310324 0.7841656220878274 0.6198216015396206 0.141548283585814 0.001309307002134 0.0 0.0092657342657342 1.0 0.0 143 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +765660 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0090983116746313 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0069047442087267 0.0238720285974944 0.0 0.000914913083257 0.2230227022447651 0.0 1093 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +765699 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0090978866754544 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0161193721503025 0.0125623889131764 0.0 0.0006145083932853 0.1979503660031968 0.0 3336 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +765883 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0090959581291584 0.7475533330314548 0.4642836810638544 0.7204611100467462 0.0029751676683741 0.0761275033764692 0.0 0.0006400409626216 0.0616421460747799 0.0 1302 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +766236 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0090917143584864 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0055862851962672 0.02871400543887 0.0 6.59862748548302e-05 0.0319317597375021 0.0 5683 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +766251 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0090915639904565 0.8023917560710954 0.7754239189773715 0.7204611100467462 0.0085367158000785 0.0147571931436988 0.0 0.0011961722488038 0.0239546101520884 0.0 38 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +766276 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes B Cells Pericytes -> B Cells 0.0090912337195696 0.9356727248601746 0.7746834992804791 0.6198216015396206 0.1750253929104546 0.00071798405859 0.0 0.0003919724051426 0.2967257961521405 0.0 1063 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +766348 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0090903992353219 0.6332974881236617 0.8794572885381431 0.6198216015396206 0.0015572459193676 0.104965956217838 0.0 0.0 0.0 0.0 103 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +766432 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0090894463866426 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0492631209980634 0.0032275631628407 0.0 0.00070323488045 0.0386671081034146 0.0 79 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +766492 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0090888012813318 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0149256517769723 0.0215025911544899 0.0 0.001255472572753 0.1508270434932732 0.0 1412 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +766621 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Endothelial Cells 11q13 Invasive Tumor Cells -> Endothelial Cells 0.0090873575247054 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0106340017102282 0.0178869147172998 0.0 0.0001503872471614 0.0257089163565994 0.0 4836 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +766629 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0090872266163045 0.2451358214448441 0.8445107771175474 0.2461374514707439 0.1327555461750915 0.0083242517891534 0.0 0.004671488848704 0.5464998772684388 0.0 316 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +766832 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0090848280805744 0.6301823358791634 0.6347970925105053 0.8824495942126559 0.0208904415011529 0.0076236123034427 0.0 0.0006065796046528 0.0540578453906331 0.0 4671 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +766856 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0090846223454498 0.4601010570874773 0.7346293219749174 0.8767341187813953 0.0587727051993296 0.0032275631628407 0.0 0.001452303302079 0.0578764269948238 0.0 2453 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +767030 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0090826357183108 0.4636527906642655 0.4630488285702799 0.8767341187813953 0.0693389464442948 0.0043013567716651 0.0 0.0012229922543823 0.0969967675769025 0.0 2453 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +767076 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0090821618934127 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0031934983073077 0.0554888093272979 0.0 0.0 0.0 0.0 1165 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +767245 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0090802685534954 0.2534163760166434 0.7746834992804791 0.2461374514707439 0.0050543892975134 0.2295016807597237 0.0 0.0034113060428849 0.2343023494940914 0.0 684 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +767262 THBS2 CD36 THBS2-CD36 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.009080111240158 0.724503440376099 0.7373999388878224 0.8293805866303694 0.0027791828709671 0.0455125113141721 0.0 0.0001678940299198 0.0381769680829232 0.0 7197 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +767661 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0090754358249917 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0055862851962672 0.0284069116891947 0.0 0.0003757985719654 0.0311290420450033 0.0 887 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +767878 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0090728192082308 0.633566764858408 0.4623922682986163 0.2461374514707439 0.0799339500711946 0.0096770075292062 0.0 0.0 0.0 0.0 184 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +767939 CD34 SELP CD34-SELP Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0090721640353022 0.8963354148873306 0.7760344326192508 0.6198216015396206 0.0038492365148421 0.0335947364052305 0.0 0.0004194630872483 0.0352830226759639 0.0 3576 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +768220 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0090687216576729 0.8498991475190484 0.9078204025796472 0.6198216015396206 0.018166235813628 0.0064028969591119 0.0 0.0001127141568981 0.0115871624805633 0.0 1109 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +768227 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.009068660181791 0.4619393085577573 0.7167436199046466 1.0 0.0051428381563772 0.0326667674102811 0.0 0.0028710247349823 0.0607763357266637 0.0 283 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +768316 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0090676288404397 0.7296454584598743 0.6580560501976399 0.6198216015396206 0.0051524613572059 0.0362497659817488 0.0 0.0 0.0 0.0 8 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +768341 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0090673527066667 0.4601010570874773 0.2550748532138862 1.0 0.0177188549930425 0.0267255153180908 0.0 0.0004193818956061 0.0260894591600898 0.0 77495 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +768385 THBS2 CD36 THBS2-CD36 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.009066895329013 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0063387366560491 0.02871400543887 0.0 0.0 0.0 0.0 1165 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +768406 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0090666426731728 0.8730912658940219 0.4596166826058663 0.8293805866303694 0.0057086106530109 0.0292373734098458 0.0 0.0019640852974186 0.2999270175075073 0.0 324 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +768462 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0090660472509887 0.7487535481622718 0.7754239189773715 0.9429656149619918 0.0637288077574987 0.0015914585039484 0.0 0.0004597560228038 0.2232070000516244 0.0 2966 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +768687 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0090633520970364 0.2534163760166434 0.8818326005152037 0.2461374514707439 0.0050543892975134 0.1993723722552783 0.0 0.0055555555555555 0.2427933082496463 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +769057 VWF LRP1 VWF-LRP1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0090589269193905 0.7158082793127664 0.7346293219749174 1.0 0.0025256125075084 0.0416128058995347 0.0 0.0003125368437742 0.012958534244846 0.0 22361 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +769166 MMRN2 CD93 MMRN2-CD93 Pericytes B Cells Pericytes -> B Cells 0.0090576855376447 0.9468422434493456 0.7779918296243433 0.6198216015396206 0.1120119983652299 0.001079730675535 0.0 0.0030573847601128 0.3358149953400525 0.0 1063 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +769203 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0090572401333481 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0033973231723341 0.0501711964086628 0.0 0.0025187104202648 0.0427352335611989 0.0 193 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +769540 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0090531555221448 0.6582846571368821 0.7461459456652184 0.6198216015396206 0.1740454925211078 0.0010390313650636 0.0 0.0003968253968253 0.0581916663402926 0.0 756 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +769697 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0090512702283923 0.6213271600240247 0.7832252605020791 0.6198216015396206 0.1339639999453202 0.00136079311934 0.0 0.0001322751322751 0.0194445677715127 0.0 756 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +769756 COL4A2 CD93 COL4A2-CD93 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0090505262059228 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0316800311254893 0.0042738820064046 0.0 0.0005 0.0425376442446832 0.0 2400 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +769802 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0090499465116094 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.002196330917593 0.1370986982961073 0.0 0.0005938242280285 0.0191299347027262 0.0 1684 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +769852 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0090492949390426 0.831981591331937 0.4642836810638544 0.7204611100467462 0.0048935684578858 0.040323117011325 0.0 0.0025252525252525 0.1756445109028789 0.0 66 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +770059 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0090469799070123 0.2542249848376565 0.62431395375366 0.2461374514707439 0.1711385759005754 0.0082011408892332 0.0 0.0037533512064343 0.6294777111595724 0.0 373 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +770095 CD48 CD2 CD48-CD2 Pericytes 11q13 Invasive Tumor Cells Pericytes -> 11q13 Invasive Tumor Cells 0.0090466035494977 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0076331962782219 0.0226890201466244 0.0 0.0 0.0 0.0 6894 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +770214 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0090452722226821 0.2490567623945399 0.896164124004365 0.2461374514707439 0.011649387573427 0.0855781119790033 0.0 0.0005760368663594 0.0290264651368344 0.0 1736 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +770269 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0090446253665931 0.8730912658940219 0.6631822525600675 0.6198216015396206 0.0057086106530109 0.0267210109213584 0.0 0.0031897926634768 0.3351635777774927 0.0 285 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +770404 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0090429848624197 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0106340017102282 0.0292791515533623 0.0 0.0017652250661959 0.041681155502193 0.0 103 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +770518 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0090415119504378 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0097699360831605 0.0176963220730796 0.0 0.0001813784764207 0.0240233178429048 0.0 827 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +770523 CCN1 CAV1 CCN1-CAV1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0090414707689611 0.7797135509308979 0.7283139964676212 0.7204611100467462 0.0009209869688402 0.1449812920932466 0.0 0.0004352278545826 0.0356746251882196 0.0 1302 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +770623 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0090402936331495 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0637288077574987 0.0027830389352876 0.0 0.0003617072582589 0.1125888341636015 0.0 377 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +770691 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0090395647077611 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0106340017102282 0.0292373734098458 0.0 0.0003785677812406 0.0578094575124455 0.0 5163 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +771020 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.009035796502765 0.6593525851613742 0.4630488285702799 0.2461374514707439 0.0201572483258557 0.0359289752254096 0.0 0.0023741690408357 0.5988805119374928 0.0 351 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +771139 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0090343000584922 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0561415215593491 0.0032275631628407 0.0 0.0008090614886731 0.0444859447597537 0.0 103 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +771318 C3 LRP1 C3-LRP1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0090322938487402 0.9487258305485792 0.9078204025796472 0.8875000050982297 0.0110943464444434 0.0064028969591119 0.0 0.000547195622435 0.1036684168385946 0.0 1462 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +771337 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0090319513124606 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0492631209980634 0.0028784826949613 0.0 0.0018012152777777 0.1331829805862968 0.0 1280 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +771460 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0090302920683426 0.6626993710110988 0.8604147465201248 0.6198216015396206 0.0035190936623492 0.0436001007095475 0.0 0.0012135922330097 0.028451800114068 0.0 103 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +771721 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0090274483968344 0.6342079770588467 0.7754072541855492 0.8693461273411047 0.0053032910137447 0.0238720285974944 0.0 0.0017391304347826 0.4239370670496143 0.0 575 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +772216 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0090214871950784 0.6626993710110988 0.6207977546603366 0.8824495942126559 0.0515877972474039 0.0028784826949613 0.0 0.0001883317987779 0.0160184434637104 0.0 11947 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +772231 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0090213171378559 0.6630837220165452 0.6587114738285964 0.8824495942126559 0.0048313935743179 0.0289462771086338 0.0 0.0001416647974783 0.0209371910232775 0.0 12101 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +772422 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.009019036586843 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.1932385901170197 0.0009761781830445 0.0 0.0021409749670619 0.8252253072889688 0.0 253 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +772756 C1QB LRP1 C1QB-LRP1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0090152589999258 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.0419710388788557 0.0032275631628407 0.0 0.0009642356241234 0.0384262107133518 0.0 713 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +772838 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0090144037361116 0.6593525851613742 0.6593689120110077 0.9161861017439124 0.0201572483258557 0.0066828239855783 0.0 0.0018195050946142 0.2241187444299268 0.0 458 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +772850 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0090143398500832 0.6605327397359113 0.657421674383923 0.9161861017439124 0.0227314494836465 0.0059327142047454 0.0 0.0003623188405797 0.0970821870321063 0.0 460 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +772888 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0090139257114906 0.4648000335061383 0.9078204025796472 0.2461374514707439 0.0357762282281787 0.0144359394371152 0.0 0.0013381321520856 0.164170073731254 0.0 1806 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +773366 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0090082602983477 0.8911088195487638 0.9078204025796472 0.9429656149619918 0.0048525806497539 0.0144359394371152 0.0 0.0002490774907749 0.0425361325944866 0.0 2710 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +773516 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0090064529125687 0.7745997874735252 0.7472387841445823 0.6198216015396206 0.0215813276111062 0.0068935067166085 0.0 0.0155038759689922 0.9427292010370022 0.0 129 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +773534 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0090061251156049 0.7745997874735252 0.4630488285702799 0.2461374514707439 0.016822895653248 0.0359289752254096 0.0 0.0 0.0 0.0 383 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +773579 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0090055952624785 0.6593525851613742 0.777821334064334 0.7917001487310438 0.0120646829101097 0.0108892901157311 0.0 0.0 0.0 0.0 193 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +773599 MMP2 PECAM1 MMP2-PECAM1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0090052783153776 0.9330801352629944 0.7167436199046466 0.7204611100467462 0.0088108219576754 0.0125623889131764 0.0 0.0004305925774041 0.1387059301821886 0.0 9754 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +773891 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0090021163121938 0.6342079770588467 0.6571792026963191 0.8824495942126559 0.000895875398841 0.1615138601457002 0.0 0.0001654259718775 0.0158118732725386 0.0 12090 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +773983 C3 LRP1 C3-LRP1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0090008973711439 0.7148920381722296 0.7346293219749174 0.8293805866303694 0.0029337538459309 0.0416128058995347 0.0 0.0016203703703703 0.1513436230061511 0.0 324 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +774079 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0089996950920548 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0255753403203798 0.0064230792457803 0.0 0.0 0.0 0.0 97 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +774084 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0089996439373439 0.8684504425765611 0.7779918296243433 0.8693461273411047 0.0168149984327668 0.0053794918117879 0.0 0.0004589787722317 0.0373544544505838 0.0 1245 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +774111 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0089993331569239 0.4625081978296446 0.885766439573873 0.7204611100467462 0.0141498126994191 0.0127192475389894 0.0 0.0022123893805309 0.3336826031571714 0.0 452 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +774151 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0089989809217357 0.4629984640915818 0.2550748532138862 0.2461374514707439 0.0683610513379333 0.0267255153180908 0.0 0.0017485699427977 0.1045249126981595 0.0 12820 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +774382 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0089960889153493 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.0120646829101097 0.0232163927704059 0.0 0.0011037527593818 0.2159668383891502 0.0 453 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +774472 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0089950586699223 0.4593282471594782 0.937587088419394 0.2461374514707439 0.0181222899145132 0.0275738893167071 0.0 0.0 0.0 0.0 176 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +774496 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0089948333131911 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0131302879503246 0.0222228052993653 0.0 5.7646855364039896e-05 0.009545711970883 0.0 1577 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +774687 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0089929030871286 0.7451589345683471 0.9015117569158254 0.7827641335561659 0.0040724665904272 0.0246995741084876 0.0 0.0030864197530864 0.2973864937301509 0.0 162 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +775001 C3 LRP1 C3-LRP1 B Cells Pericytes B Cells -> Pericytes 0.0089892184441985 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0042375227960614 0.0350138403862125 0.0 0.0016102394715111 0.141453936305039 0.0 1211 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +775005 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0089891745182471 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0208904415011529 0.0079745943515326 0.0 0.0004030632809351 0.0482962228852211 0.0 827 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +775015 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0089890716153828 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.4344545964241579 0.0003375370073613 0.0 0.0013422818791946 1.0 0.0 1490 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +775205 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0089868904512559 0.6593525851613742 0.6593689120110077 1.0 0.018132161410931 0.0066828239855783 0.0 0.000503429614247 0.0620102759744196 0.0 5297 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +775234 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0089866112798326 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.0026436039558049 0.0587195251380622 0.0 0.0002101785050931 0.0148188273807138 0.0 5683 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +775450 VWF SELP VWF-SELP CAFs, DCIS Associated CAFs, DCIS Associated CAFs, DCIS Associated -> CAFs, DCIS Associated 0.0089842580736839 0.7158082793127664 0.4623922682986163 1.0 0.0071496754272206 0.0222228052993653 0.0 6.3208461506047e-05 0.0104666553595871 0.0 94924 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +775968 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.008977768444101 0.250044481781731 0.9003264838243337 0.2461374514707439 0.0070431301838115 0.1341680150528327 0.0 0.0023041474654377 0.0573765541728025 0.0 1736 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +776718 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.00896902714366 0.6589792304505506 0.8604147465201248 0.6198216015396206 0.0033973231723341 0.0436001007095475 0.0 0.0063025210084033 0.1448364224197924 0.0 119 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +776829 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0089674977044085 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0016575843792215 0.12709315903692 0.0 0.0009635149023638 0.0453901686307102 0.0 3336 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +776853 CD34 SELP CD34-SELP CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0089672319216318 0.633566764858408 0.6572093097629401 0.9161861017439124 0.0298399317533219 0.0045674276780054 0.0 0.0009505703422053 0.2903769561954141 0.0 526 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +776883 DLL1 NOTCH3 DLL1-NOTCH3 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0089668151538073 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.00263399584678 0.0606066271159369 0.0 0.0 0.0 0.0 50 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +776929 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.0089662367821796 0.6303682835571691 0.773263018678637 0.946515890536252 0.0342558468646473 0.0032875740549697 0.0 0.0014405256413564 0.2324359922367644 0.0 11074 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +776945 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.008966052279715 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0020251995753771 0.0741032966028748 0.0 0.0002268945696566 0.0052331968559382 0.0 1803 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +777063 CD34 SELP CD34-SELP Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0089648266449688 0.9303167350027568 0.6572093097629401 0.6198216015396206 0.1314667522621683 0.0010419094417808 0.0 0.0 0.0 0.0 377 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +777165 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0089637239111883 0.6242573126045354 0.6176321640000088 0.9161861017439124 0.1932385901170197 0.0007598956708367 0.0 0.0006340579710144 0.2982406176824255 0.0 460 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +777299 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0089620004652099 0.6332974881236617 0.6252253442669611 0.8824495942126559 0.0131302879503246 0.0112932915661816 0.0 0.0002130622370013 0.0079830032824462 0.0 11947 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +777327 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0089617339539394 0.4648000335061383 0.6207977546603366 0.2461374514707439 0.0357762282281787 0.0203874717835032 0.0 0.0018939393939393 0.112299308377517 0.0 902 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +777572 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0089588971314716 0.9219165193585238 0.7283139964676212 0.7204611100467462 0.0086134406931133 0.0124087765732037 0.0 0.0004678362573099 0.0230641466602547 0.0 285 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +777635 C1QB LRP1 C1QB-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0089582331962716 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.0419710388788557 0.0028784826949613 0.0 0.0012886597938144 0.1096061535286074 0.0 97 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +777787 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0089563853148726 0.7160288858520609 0.4638256179742202 0.2461374514707439 0.0012306151710811 0.5131068416842878 0.0 0.002460024600246 0.0558848997999554 0.0 271 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +777796 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.008956241659939 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0039530346951707 0.0350138403862125 0.0 0.0016304347826086 0.0573188724087535 0.0 345 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +777852 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0089555469648589 0.9468422434493456 0.7154802332407408 0.7204611100467462 0.1120119983652299 0.0009436211854823 0.0 0.0008460236886632 0.0941086776539541 0.0 394 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +778460 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0089484338416623 0.8818165186409654 0.7346293219749174 0.7204611100467462 0.0026436039558049 0.0416128058995347 0.0 0.0004644373673036 0.0153361002709261 0.0 1884 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +778709 VWF LRP1 VWF-LRP1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0089452855035792 0.9011206516381156 0.6207977546603366 0.6198216015396206 0.0008850282134344 0.166956519448744 0.0 0.0017792399624009 0.0134061504011281 0.0 1354 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +778832 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0089439912687877 0.7451589345683471 0.7167436199046466 0.7204611100467462 0.0040724665904272 0.0326667674102811 0.0 0.0 0.0 0.0 37 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +778848 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0089438341675809 0.7475533330314548 0.885766439573873 0.7827641335561659 0.0029751676683741 0.0331922776397286 0.0 0.0003623188405797 0.0402215539580646 0.0 460 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +779219 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0089397142202062 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.1194227711616854 0.0023576674662702 0.0 0.0001621271076523 0.0503298379077904 0.0 1542 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +779325 CD34 SELP CD34-SELP Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0089385721725959 0.7871981482311898 0.6572093097629401 0.6198216015396206 0.0038506427265089 0.04130664769978 0.0 0.0 0.0 0.0 1154 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +779390 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0089378745651996 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0411127335336962 0.0026482500471321 0.0 0.0009529977794226 0.870376254915106 0.0 2702 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +779442 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0089371969626416 0.7487535481622718 0.4600037439857229 0.2461374514707439 0.0338862305197021 0.017738069381683 0.0 0.0010369858278603 0.2585310399371113 0.0 263 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +779608 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0089354488677094 0.6342079770588467 0.6580560501976399 0.9161861017439124 0.002196330917593 0.0606066271159369 0.0 0.0 0.0 0.0 526 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +779939 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0089315993866541 0.6659645551150886 0.937587088419394 0.7917001487310438 0.0037243679732516 0.0275738893167071 0.0 0.0 0.0 0.0 38 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +779983 C3 LRP1 C3-LRP1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0089309541532309 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0042375227960614 0.0416128058995347 0.0 5.040322580645161e-05 0.0047076933423572 0.0 496 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +780082 COL4A2 CD93 COL4A2-CD93 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0089298485126907 0.7482742921073442 0.6587114738285964 0.6198216015396206 0.005733874009046 0.0289462771086338 0.0 0.001213171577123 0.2582823770160161 0.0 1154 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +780095 CD34 SELP CD34-SELP Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.008929697807613 0.7168245244832976 0.4623922682986163 0.8293805866303694 0.0082993421103349 0.0222228052993653 0.0 0.0005557871335278 0.14851381141296 0.0 7197 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +780288 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0089272402350856 0.9356727248601746 0.4638256179742202 0.7204611100467462 0.1750253929104546 0.0009249287638231 0.0 0.0002115059221658 0.1217677061832431 0.0 394 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +780694 C1QB LRP1 C1QB-LRP1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.0089225740324894 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0161519521398178 0.0104714078116759 0.0 0.0008977149075081 0.0897856616202051 0.0 4595 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +781096 CD48 CD2 CD48-CD2 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.008917919051983 0.7719609236370527 0.7763428264267787 1.0 0.0164675938709007 0.0050968401714881 0.0 0.0002347601533766 0.0597450245822266 0.0 12779 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +781190 JAG1 NOTCH2 JAG1-NOTCH2 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0089168308329162 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0001109003117737 1.0 0.0 0.0013742008723188 0.0235569818791813 0.0 797 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +781208 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.008916575380148 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0673400749834054 0.0040904475843412 0.0 0.0 0.0 0.0 103 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +781241 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0089161859674036 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0515877972474039 0.0032275631628407 0.0 0.0 0.0 0.0 103 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +781345 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0089149801859472 0.6249837837987587 0.7746834992804791 0.8693461273411047 0.1661175896787547 0.00071798405859 0.0 0.0003086419753086 0.2336440898590559 0.0 270 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +781373 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0089146281960655 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.4103175828613323 0.0003375370073613 0.0 0.0008149568552253 0.7100986457743692 0.0 1490 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +781476 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0089131785092322 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0361307801045652 0.0049190726392343 0.0 0.0022842639593908 0.279025659095482 0.0 394 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +781542 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0089123451280868 0.6160088550075702 0.7447682696221608 0.6198216015396206 0.0548063857429699 0.0032154705418133 0.0 0.0 0.0 0.0 143 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +781674 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0089107930475261 0.7475533330314548 0.7763400818577846 0.6198216015396206 0.0029751676683741 0.0467761235673353 0.0 0.0 0.0 0.0 144 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +781895 CCN1 CAV1 CCN1-CAV1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0089079954077382 0.6213271600240247 0.62431395375366 0.8693461273411047 0.0023088899408624 0.0641739251983978 0.0 0.0004629629629629 0.0439792473136702 0.0 360 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +781983 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0089068627043548 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0141923232885854 0.0125623889131764 0.0 0.0003883629010019 0.1251025685497751 0.0 10879 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +782320 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0089031982355062 0.8730912658940219 0.7754239189773715 0.7204611100467462 0.0057086106530109 0.0178869147172998 0.0 0.0013568521031207 0.231955819963647 0.0 536 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +782483 VWF SELP VWF-SELP Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0089014983582295 0.9275752708651288 0.6572093097629401 0.6198216015396206 0.1263644540569636 0.0010419094417808 0.0 0.0 0.0 0.0 377 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +782735 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0088981911104624 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0039530346951707 0.0416128058995347 0.0 0.0015176600441501 0.0601279712542893 0.0 453 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +782941 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0088956677142514 0.6605327397359113 0.657421674383923 0.9161861017439124 0.0179229861158654 0.0069492509109592 0.0 0.0 0.0 0.0 408 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +782984 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0088951259087844 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0113788029360913 0.0125623889131764 0.0 0.0003372302158273 0.1565705520358711 0.0 3336 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +783356 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0088908529483377 0.7800321422220979 0.2491073778594529 0.2461374514707439 0.1357656553382984 0.0076066460958003 0.0 0.0018529076396807 0.7719354698410428 0.0 877 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +783458 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0088896949146702 0.4625081978296446 0.885766439573873 0.2461374514707439 0.3558005706994493 0.0013756087909864 0.0 0.0 0.0 0.0 1384 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +783595 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0088880900343691 0.718867305289982 0.7167436199046466 1.0 0.0361307801045652 0.0026482500471321 0.0 0.00032981530343 0.3012214874068983 0.0 22361 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +783616 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0088877407145723 0.2534163760166434 0.8818326005152037 0.2461374514707439 0.2100740470724093 0.0042655619249233 0.0 0.0013848747591522 0.3507032771937121 0.0 1384 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +783671 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0088871105418544 0.6605327397359113 0.4642836810638544 0.6198216015396206 0.0179229861158654 0.0144613249009303 0.0 0.2 1.0 0.2 5 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +783736 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Mast Cells Pericytes -> Mast Cells 0.0088863233499039 0.8640667164982425 0.8537710813834968 0.8567148457705164 0.1882781599600688 0.0004138063814779 0.0 0.0013888888888888 0.1213592233009709 0.0 225 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +783858 VWF SELP VWF-SELP T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0088849772316318 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0036144684673052 0.04130664769978 0.0 3.901677721420211e-05 0.0132428594574714 0.0 1165 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +783956 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0088839968589936 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0069047442087267 0.0244129856070659 0.0 0.0015174506828528 0.0532915257383544 0.0 659 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +784000 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0088834761443885 0.2510234128936706 0.8587566561291643 0.2461374514707439 0.0009262556366009 1.0 0.0 0.0023301956441491 0.0334579074133231 0.0 1806 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +784074 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.008882547394589 0.9219165193585238 0.252518874138558 0.2461374514707439 0.4529166025129413 0.0018925243453249 0.0 0.0202020202020202 1.0 0.0 33 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +784312 COL4A1 CD93 COL4A1-CD93 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0088796827212369 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0126216524880575 0.0155837683010033 0.0 0.0002691949102464 0.0634311137342978 0.0 10879 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +784393 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0088786464181629 0.250044481781731 0.8817184225858201 0.2461374514707439 0.0070431301838115 0.1281708518900828 0.0 0.0024481566820276 0.0505615983532622 0.0 1736 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +784404 CD34 SELP CD34-SELP Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0088784996842082 0.7871981482311898 0.7760344326192508 0.6198216015396206 0.0038506427265089 0.0335947364052305 0.0 0.0012886597938144 0.1083952655405901 0.0 388 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +784487 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0088777484241865 0.6593525851613742 0.4630488285702799 0.2461374514707439 0.018132161410931 0.0359289752254096 0.0 0.0 0.0 0.0 155 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +784757 VWF LRP1 VWF-LRP1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0088748671136669 0.7158082793127664 0.8604147465201248 0.7204611100467462 0.0025256125075084 0.0436001007095475 0.0 0.0003845562221196 0.0073357110733203 0.0 591 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +784798 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0088743391292568 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0008320501336843 0.1615013370958009 0.0 0.001159420289855 0.0358088142630485 0.0 345 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +785149 A2M LRP1 A2M-LRP1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0088702672449563 0.7460047258226694 0.6207977546603366 0.6198216015396206 0.0010163752993685 0.166956519448744 0.0 0.0033854166666666 0.0330111216715264 0.0 160 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +785195 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0088696700411153 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0172764782878141 0.0155837683010033 0.0 0.0003125 0.0424989979533469 0.0 800 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +785207 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0088695761558908 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0012306151710811 0.0855781119790033 0.0 0.0 0.0 0.0 452 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +785586 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0088645299562406 0.6160088550075702 0.9546923450729716 0.8693461273411047 0.0021291294377375 0.0445745465878424 0.0 0.001010101010101 0.0374092614103452 0.0 270 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +785763 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0088625532387637 0.9184503888425788 0.7470475610360806 0.7827641335561659 0.1169448695751571 0.0007714919761827 0.0 0.0015822784810126 0.4589973321652313 0.0 316 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +785827 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0088618488610117 0.7800321422220979 0.6331674633943454 0.9318789094584046 0.0213929720256037 0.0049190726392343 0.0 0.0003617764471057 0.0731546961502452 0.0 5010 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +785897 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0088610698410747 0.2542249848376565 0.9694036398779844 0.2461374514707439 0.0014656941948563 0.5444650460041837 0.0 0.0222222222222222 0.44244361505532 0.0 9 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +785932 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0088606965627285 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.013905026986541 0.0124087765732037 0.0 0.0014960261804581 0.0737535124619645 0.0 713 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +785971 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0088601631179356 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0051428381563772 0.0518891167572028 0.0 0.0018450184501845 0.0944305322607875 0.0 271 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +786015 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0088595410694301 0.6582846571368821 0.6587114738285964 0.8824495942126559 0.1740454925211078 0.0007261054236978 0.0 0.0001830282861896 0.0281087342595647 0.0 12020 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +786042 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0088591744509646 0.2542249848376565 0.8818704453527788 0.2461374514707439 0.1711385759005754 0.0051192928876727 0.0 0.0006006006006006 0.1131499816888081 0.0 222 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +786083 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0088587133662336 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0117842887908422 0.0118035014556376 0.0 0.0002154429507066 0.0165060992210966 0.0 11604 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +786108 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.00885842645151 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0071496754272206 0.0144359394371152 0.0 0.000448409326914 0.0396101472154381 0.0 16371 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +786226 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0088569867494576 0.7797302331085993 0.657421674383923 0.7917001487310438 0.0200499113739789 0.0059327142047454 0.0 0.0 0.0 0.0 42 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +786236 HSPG2 LRP1 HSPG2-LRP1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0088568318103628 0.8818165186409654 0.7769451595923457 0.7827641335561659 0.1619074107723045 0.0005558995075445 0.0 0.0029887482419127 0.4417051541658737 0.0 316 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +786266 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0088564692046983 0.6301823358791634 0.6347970925105053 0.8824495942126559 0.0024635726452692 0.0554888093272979 0.0 0.0003994160262237 0.0653673138342783 0.0 12101 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +786353 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0088554236417083 0.6249837837987587 0.7470475610360806 0.6198216015396206 0.2159908053119969 0.0007714919761827 0.0 0.0 0.0 0.0 756 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +786398 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0088549219663804 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.0142750905665976 0.0104714078116759 0.0 0.0 0.0 0.0 83 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +786668 VWF ITGA9 VWF-ITGA9 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0088514741725465 0.7848266128497919 0.7292496872084557 0.7204611100467462 0.0004024409845247 0.2898144908728011 0.0 0.0 0.0 0.0 85 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +786686 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0088513000919912 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0072827533047186 0.0203874717835032 0.0 0.0019050659855257 0.0595125642389733 0.0 1305 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +786840 C3 LRP1 C3-LRP1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0088495121629844 0.7148920381722296 0.9078204025796472 0.7204611100467462 0.0029337538459309 0.0350138403862125 0.0 0.0023783185840707 0.2089270145567363 0.0 452 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +787140 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0088459215890843 0.6301823358791634 0.6347970925105053 0.8693461273411047 0.0172764782878141 0.0079745943515326 0.0 0.0 0.0 0.0 575 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +787296 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0088441752880865 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0075637985935472 0.0144359394371152 0.0 0.0011552680221811 0.1010937840699413 0.0 2164 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +787309 THBS2 CD36 THBS2-CD36 Mast Cells Pericytes Mast Cells -> Pericytes 0.0088439524679991 0.8581959463413404 0.8587566561291643 0.8567148457705164 0.0002636300075004 0.287457858136305 0.0 0.0023907103825136 0.0727099169343886 0.0 244 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +787466 VWF ITGA9 VWF-ITGA9 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0088421551541869 0.7848266128497919 0.7292496872084557 0.7204611100467462 0.0004024409845247 0.2879885658616873 0.0 0.0002094679514034 0.0077192283690934 0.0 1302 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +787676 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0088396630315675 0.6593525851613742 0.8998347793593909 0.6198216015396206 0.0201572483258557 0.0064362797035136 0.0 0.0 0.0 0.0 103 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +787732 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0088387986021944 0.4629984640915818 0.7769451595923457 0.7204611100467462 0.3309594876493178 0.0005558995075445 0.0 0.0020081588022541 0.2967844801713881 0.0 1321 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +788026 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0088350710186843 0.7487535481622718 0.7447682696221608 0.7827641335561659 0.0338862305197021 0.0032154705418133 0.0 0.0025393600812595 0.215551524670696 0.0 179 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +788105 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0088342673809911 0.9184503888425788 0.7746834992804791 0.6198216015396206 0.0004696576149175 0.2295016807597237 0.0 0.0002502502502502 0.0124400986641515 0.0 1332 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +788142 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.008833876293763 0.9468422434493456 0.6347970925105053 0.6198216015396206 0.1120119983652299 0.0011388334136451 0.0 0.0030946065428824 0.4120070629782228 0.0 377 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +788158 C1QB LRP1 C1QB-LRP1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.00883364813282 0.7753420160918723 0.9078204025796472 0.9429656149619918 0.0111808254589153 0.0064028969591119 0.0 0.0002528658125421 0.0259949356526191 0.0 2966 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +788379 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0088309987785438 0.6301823358791634 0.7779918296243433 1.0 0.0015409900107563 0.0627790816848129 0.0 0.00043630017452 0.0095541717843698 0.0 4011 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +788489 C3 LRP1 C3-LRP1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0088296640747563 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.0029337538459309 0.0587195251380622 0.0 0.0 0.0 0.0 148 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +788641 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0088279121325406 0.6213271600240247 0.7832252605020791 0.6198216015396206 0.1153131738111426 0.00136079311934 0.0 0.0069767441860465 1.0 0.0 129 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +788671 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0088274532980599 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0018436902762588 0.0741032966028748 0.0 0.0 0.0 0.0 345 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +788682 CD48 CD2 CD48-CD2 Endothelial Cells CAFs, DCIS Associated Endothelial Cells -> CAFs, DCIS Associated 0.0088273046140848 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0164675938709007 0.0112209532878862 0.0 0.0002510400229522 0.0493248692001849 0.0 13942 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +788835 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0088254180028038 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.1882781599600688 0.0007400708115376 0.0 0.0004973474801061 0.0970775609262817 0.0 377 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +789035 COL4A2 CD93 COL4A2-CD93 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0088229538704999 0.9188764516910942 0.7779918296243433 0.6198216015396206 0.0090193130488293 0.0118035014556376 0.0 0.0004474272930648 0.0452787671818954 0.0 3576 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +789231 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0088204436396698 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0411127335336962 0.0032187363284526 0.0 0.0023211314475873 0.6753021486978236 0.0 3005 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +789272 CCN1 CAV1 CCN1-CAV1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0088198131415818 0.7324582304061453 0.62431395375366 0.6198216015396206 0.0025580826958339 0.0649213179279442 0.0 0.0015204678362573 0.0626452621658114 0.0 285 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +789558 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0088164042671805 0.2534163760166434 0.7746834992804791 0.2461374514707439 0.2100740470724093 0.0046263543438723 0.0 0.0018459915611814 0.6493850825820685 0.0 316 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +790061 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0088106356996556 0.7745997874735252 0.8998347793593909 0.6198216015396206 0.016822895653248 0.0064362797035136 0.0 0.0002421776615325 0.0877465423776184 0.0 3441 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +790107 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Endothelial Cells Endothelial Cells -> Endothelial Cells 0.0088100528710876 0.6303682835571691 0.773263018678637 1.0 0.0291791383241764 0.0032875740549697 0.0 0.0010620102176561 0.1713606419904227 0.0 12779 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +790185 MMP2 PECAM1 MMP2-PECAM1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0088092221463487 0.6303642896310324 0.6331674633943454 0.909150863993142 0.0024819960935566 0.0518891167572028 0.0 0.0013718528082633 0.0500873908695714 0.0 1549 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +790260 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0088085268260858 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0110717612136884 0.0144613249009303 0.0 0.0012690355329949 0.0073543591738276 0.0 394 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +790698 CCN1 CAV1 CCN1-CAV1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0088028086931018 0.7324582304061453 0.62431395375366 0.6198216015396206 0.0025580826958339 0.0641739251983978 0.0 0.0018518518518518 0.1759169892546809 0.0 126 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +790745 CD48 CD2 CD48-CD2 B Cells Macrophages B Cells -> Macrophages 0.0088022324041986 0.9426443637490616 0.7763428264267787 0.6198216015396206 0.0632786830726401 0.0016204239758814 0.0 0.0004694835680751 0.0851057572422524 0.0 1065 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +790758 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0088020210475296 0.4630253981438691 0.4630027772793905 1.0 0.0443339118517084 0.0048929293424311 0.0 0.000172914381573 0.0559106757300187 0.0 77495 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +790763 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0088019997568391 0.7160288858520609 0.4641352222874551 0.8293805866303694 0.0012306151710811 0.1370986982961073 0.0 0.0 0.0 0.0 324 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +790888 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0088006688072926 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0106340017102282 0.0147571931436988 0.0 0.001082251082251 0.0216732187090323 0.0 42 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +790991 COL4A2 CD93 COL4A2-CD93 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0087994467588678 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0267593032157803 0.0042738820064046 0.0 0.0016108520559559 0.1370437033741383 0.0 2359 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +791035 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.008798988171741 0.8978557803479422 0.885766439573873 0.8875000050982297 0.0477973731763516 0.0013756087909864 0.0 0.0 0.0 0.0 1462 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +791069 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0087986793950359 0.4630253981438691 0.7779918296243433 0.2461374514707439 0.0443339118517084 0.0118035014556376 0.0 0.000632911392405 0.0640493953490736 0.0 316 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +791082 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0087985162655768 0.6213271600240247 0.62431395375366 0.909150863993142 0.013905026986541 0.009460730808256 0.0 0.0003527642840619 0.0437978136212941 0.0 5764 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +791213 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0087970068984451 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.0070489045197697 0.0203874717835032 0.0 0.0022816624543667 0.1352889730243044 0.0 1187 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +791249 HSPG2 LRP1 HSPG2-LRP1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0087965732439919 0.9253089325030373 0.6207977546603366 0.6198216015396206 0.0022161183602947 0.0587195251380622 0.0 0.0001437607820586 0.0101359851831628 0.0 1739 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +791320 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0087956355415405 0.6213271600240247 0.8617632615906476 0.6198216015396206 0.1339639999453202 0.0010414441948928 0.0 0.0 0.0 0.0 42 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +791372 CCN1 CAV1 CCN1-CAV1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0087949952398607 0.7324582304061453 0.62431395375366 0.6198216015396206 0.0025580826958339 0.0638329144736252 0.0 0.0006756756756756 0.1763907795328171 0.0 148 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +791455 VWF SELP VWF-SELP Macrophages Pericytes Macrophages -> Pericytes 0.0087941947751193 0.9011206516381156 0.8819126042133903 0.8875000050982297 0.0008850282134344 0.0741032966028748 0.0 0.000643051370618 0.0148316216470844 0.0 2474 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +791485 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0087938379823768 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0415873844357376 0.0058437228618857 0.0 9.684292078249076e-05 0.0236043404054186 0.0 5163 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +791558 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0087931249214033 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0135527119637784 0.0104714078116759 0.0 0.000625 0.0625098659310367 0.0 2300 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +791697 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.008791585264643 0.6605327397359113 0.657421674383923 1.0 0.0179229861158654 0.0059327142047454 0.0 0.0007222824124232 0.1935332872579367 0.0 1846 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +791873 COL4A1 CD93 COL4A1-CD93 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0087894266395986 0.9102252263107924 0.6587114738285964 0.6198216015396206 0.0042860632265532 0.0289462771086338 0.0 8.214901831923108e-05 0.0121411227033104 0.0 1739 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +792025 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0087878124048865 0.2491408586098361 0.930308383061206 0.2461374514707439 0.0049987108499989 0.1615013370958009 0.0 0.0015697004608294 0.048480359316026 0.0 1736 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +792073 CCN1 CAV1 CCN1-CAV1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0087871108587146 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0023088899408624 0.0649213179279442 0.0 0.0006542699724517 0.0269567780219221 0.0 968 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +792221 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.0087854104914466 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0351142257737683 0.0050968401714881 0.0 0.000122167246961 0.0310908178745454 0.0 16371 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +792307 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0087843411254585 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0035190936623492 0.0350138403862125 0.0 0.0 0.0 0.0 379 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +792373 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0087835625389584 0.7160288858520609 0.8818120773736414 0.7204611100467462 0.0186793449598515 0.0054043611446182 0.0 9.9601593625498e-05 0.0195289835802421 0.0 10040 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +792727 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0087794558489076 0.2490567623945399 0.7754072541855492 0.2461374514707439 0.011649387573427 0.0826982152707935 0.0 0.0 0.0 0.0 902 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +792828 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Pericytes B Cells -> Pericytes 0.0087783100931294 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0052742025956585 0.0293031867940321 0.0 0.0016139929434727 0.2019919468647507 0.0 1211 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +792915 CD34 SELP CD34-SELP CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0087773219741791 0.7168245244832976 0.8347297932672282 0.7204611100467462 0.1173076386135379 0.0009042150166242 0.0 0.0004621072088724 0.0740029338051979 0.0 1082 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +792959 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0087768027759774 0.8640667164982425 0.9015117569158254 0.8875000050982297 0.002676946692949 0.0246995741084876 0.0 0.0004827949438202 0.0465188493528027 0.0 1424 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +793189 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0087740034242775 0.2451358214448441 0.773263018678637 0.2461374514707439 0.1327555461750915 0.0073658308476012 0.0 0.0052552552552552 0.9568479944488788 0.0 222 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +793240 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0087734667069442 0.7205550478301406 0.7154802332407408 1.0 0.0151307911035231 0.0058465532256424 0.0 0.0002757777678398 0.0580421913612546 0.0 22361 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +793264 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0087731223839406 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0009153913192522 0.166956519448744 0.0 0.0023294655414908 0.0246821978074912 0.0 1422 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +793307 CXCL12 ITGA4 CXCL12-ITGA4 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0087726717424957 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0052742025956585 0.0267210109213584 0.0 0.0022539444027047 0.2368304619832696 0.0 968 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +793345 VWF ITGA9 VWF-ITGA9 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.008772269745281 0.7158082793127664 0.7292496872084557 0.8767341187813953 0.0003457348439318 0.2879885658616873 0.0 0.0004081632653061 0.0150414678506334 0.0 2450 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +793358 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0087721584526716 0.6301823358791634 0.7779918296243433 1.0 0.0172764782878141 0.0053794918117879 0.0 0.000268185533306 0.0323732490136973 0.0 19576 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +793642 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0087687571894551 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.016822895653248 0.0066828239855783 0.0 0.0004166666666666 0.0513231924744532 0.0 2400 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +793665 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0087685225969668 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0053032910137447 0.046975263367762 0.0 0.0 0.0 0.0 800 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +793696 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0087681823529085 0.2490567623945399 0.4641352222874551 0.2461374514707439 0.011649387573427 0.1370986982961073 0.0 0.0020206555904804 0.0650950360023616 0.0 13362 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +793861 C3 LRP1 C3-LRP1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0087661767973558 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0064915662046245 0.0203874717835032 0.0 0.0004819888381532 0.0616518834744068 0.0 1971 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +793882 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0087659725072882 0.4601010570874773 0.2550748532138862 0.2461374514707439 0.0587727051993296 0.0267255153180908 0.0 0.0002390472878998 0.0148709672981456 0.0 5752 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +793924 VEGFC FLT1 VEGFC-FLT1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0087654985163744 0.8317042416754105 0.878254460598671 0.8567148457705164 0.0005440770361181 0.1332188634280341 0.0 0.003415300546448 0.1287232138382585 0.0 244 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +794158 CCN1 CAV1 CCN1-CAV1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0087623849773151 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0023088899408624 0.0638329144736252 0.0 0.0002927645336679 0.0764286271836045 0.0 797 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +794426 HSPG2 LRP1 HSPG2-LRP1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0087592031363199 0.9253089325030373 0.7346293219749174 0.7204611100467462 0.0022161183602947 0.0416128058995347 0.0 0.0009518259518259 0.0314300684340285 0.0 715 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +794506 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.008758174177124 0.7160288858520609 0.7480927101953669 0.7204611100467462 0.0186793449598515 0.006260692484444 0.0 0.0 0.0 0.0 1321 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +794833 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0087540282887766 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.0026436039558049 0.0501711964086628 0.0 0.000720280596267 0.0122210791933104 0.0 887 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +795091 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0087508361568607 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.454846709299195 0.0003375370073613 0.0 0.0001493930905695 0.1301711012323027 0.0 11475 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +795141 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Plasma Cells B Cells -> Plasma Cells 0.008750319466347 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0052742025956585 0.0484993884807927 0.0 0.0085705540250994 0.1218431118237997 0.0 297 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +795152 C3 LRP1 C3-LRP1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0087502105287943 0.8911088195487638 0.9078204025796472 0.9429656149619918 0.0091898156146168 0.0064028969591119 0.0 0.0004130141604855 0.0782471978831258 0.0 2966 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +795172 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0087499674829742 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0034559943126159 0.0455125113141721 0.0 5.28429507503699e-05 0.0120158152446941 0.0 1577 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +795235 CD48 CD2 CD48-CD2 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0087494057329375 0.4593282471594782 0.8581827408615759 0.6198216015396206 0.0467114894617178 0.003930762149527 0.0 0.0039682539682539 1.0 0.0 126 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +795703 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.008743769289316 0.6342079770588467 0.8923034233058523 0.6198216015396206 0.0673400749834054 0.00189193058407 0.0 0.0001233654083395 0.0545764441974451 0.0 1351 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +795902 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0087417513447824 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0070532058552773 0.0144359394371152 0.0 0.0003903337061894 0.0341568455553986 0.0 4768 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +796365 HSPG2 LRP1 HSPG2-LRP1 Pericytes Mast Cells Pericytes -> Mast Cells 0.0087358312913074 0.8818165186409654 0.8755243548400705 0.8567148457705164 0.1619074107723045 0.0004150165744076 0.0 0.0032098765432098 0.4461604461604465 0.0 225 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +796445 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Mast Cells Pericytes -> Mast Cells 0.0087347773586916 0.9468422434493456 0.8514619504364779 0.8567148457705164 0.1120119983652299 0.0005740632036187 0.0 0.0051851851851851 0.8962868117797695 0.0 225 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +796606 VWF ITGA9 VWF-ITGA9 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.008732981500929 0.6332974881236617 0.6252253442669611 1.0 0.0036144684673052 0.0309945332907452 0.0 0.000158572334699 0.0098915647932131 0.0 21212 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +796656 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0087321885787431 0.7797135509308979 0.7283139964676212 0.7204611100467462 0.0009209869688402 0.1176565474247238 0.0 0.0007843137254901 0.0538742721176724 0.0 85 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +796658 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0087321825532968 0.8516956437178343 0.7746834992804791 0.6198216015396206 0.000472352586488 0.2295016807597237 0.0 0.0 0.0 0.0 30 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +796768 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0087307213823192 0.4593282471594782 0.4603649459881741 0.8293805866303694 0.0351142257737683 0.0071918009517169 0.0 0.0002523977788995 0.061689235400103 0.0 9905 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +796879 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0087293875604849 0.9184503888425788 0.896164124004365 0.9429656149619918 0.1169448695751571 0.0004874986369898 0.0 0.0 0.0 0.0 2966 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +796995 VEGFC FLT1 VEGFC-FLT1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0087279381163108 0.8317042416754105 0.6593689120110077 0.6198216015396206 0.0005440770361181 0.2390217618875283 0.0 0.0 0.0 0.0 78 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +797042 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0087274047621395 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0035190936623492 0.0416128058995347 0.0 0.0010504201680672 0.0416164568039619 0.0 714 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +797265 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0087247448252099 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0033973231723341 0.0350138403862125 0.0 0.0014492753623188 0.0620449760640071 0.0 345 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +797448 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0087225815928338 0.4636527906642655 0.8998347793593909 0.2461374514707439 0.0666348171285698 0.0064362797035136 0.0 0.0 0.0 0.0 222 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +797561 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0087212045095092 0.8533682807143209 0.7779918296243433 0.8693461273411047 0.0706049302656684 0.001079730675535 0.0 0.0026455026455026 0.4072095939603259 0.0 270 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +797601 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0087207479919384 0.6301823358791634 0.944024288971064 0.6198216015396206 0.0024635726452692 0.0484215930647349 0.0 0.0 0.0 0.0 103 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +797705 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.008719523942212 0.2451358214448441 0.773263018678637 0.2461374514707439 0.1327555461750915 0.0070956399217802 0.0 0.0047728768926925 0.5990129616987989 0.0 1736 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +797722 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0087192081025563 0.4625081978296446 0.4642836810638544 1.0 0.0141498126994191 0.0144613249009303 0.0 0.002944640753828 0.017064885244335 0.0 283 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +797893 CD48 CD2 CD48-CD2 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0087169746082232 0.7453966474499909 0.6614977577544194 0.6198216015396206 0.006326966401379 0.0226890201466244 0.0 0.0012998266897746 0.1883969904471298 0.0 1154 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +798083 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0087148059865235 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0016417770622885 0.1076178292491983 0.0 0.0027945157628154 0.2341265684477833 0.0 1041 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +798176 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0087137856168109 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.0047694898966413 0.0289462771086338 0.0 0.0001508257710967 0.0222911269199966 0.0 5683 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +798464 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0087105298667024 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0052742025956585 0.0279580382843415 0.0 0.0016567263088137 0.2323203983882954 0.0 1509 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +798494 THBS2 CD36 THBS2-CD36 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0087100980131539 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.004981832968137 0.02871400543887 0.0 4.224757076468103e-05 0.0204442405957724 0.0 3945 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +798604 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0087086061218909 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.0208904415011529 0.0053794918117879 0.0 0.0002138157894736 0.0258101610118979 0.0 30400 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +798695 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0087075374135188 0.6319926036888139 0.6207977546603366 0.9161861017439124 0.0007263013575398 0.166956519448744 0.0 0.0009825327510917 0.0138188691319146 0.0 458 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +799051 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0087033020687508 0.2491449441646273 0.8819126042133903 0.2461374514707439 0.0108445362943651 0.0741032966028748 0.0 0.0 0.0 0.0 1736 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +799263 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0087006602755445 0.2486570577556728 0.7292496872084557 0.2461374514707439 0.0033537993821664 0.2898144908728011 0.0 0.0006463376467866 0.0150110878677448 0.0 13362 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +799269 VWF ITGA9 VWF-ITGA9 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0087006249018679 0.7158082793127664 0.7292496872084557 0.8293805866303694 0.0003457348439318 0.2898144908728011 0.0 0.0008417508417508 0.0195495278838993 0.0 324 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +799297 VWF LRP1 VWF-LRP1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0087003338248046 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0036144684673052 0.0416128058995347 0.0 0.0004712619149238 0.0195396599936347 0.0 1278 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +799349 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0086997600055498 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0244483651952677 0.0046263543438723 0.0 0.002008032128514 0.706387903944694 0.0 83 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +799802 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0086943068400739 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.0198024073017111 0.0053794918117879 0.0 0.0004597701149425 0.0496329112809262 0.0 1305 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +799887 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0086933578493603 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0053032910137447 0.0446401662952339 0.0 0.0001819505094614 0.0164662254885598 0.0 6412 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +800028 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0086915000372308 0.2486570577556728 0.7292496872084557 0.2461374514707439 0.0033537993821664 0.2879885658616873 0.0 0.0005217164471109 0.0192260838575985 0.0 4879 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +800093 COL4A2 CD93 COL4A2-CD93 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.008690598056826 0.9188764516910942 0.4630027772793905 0.7204611100467462 0.0090193130488293 0.0155837683010033 0.0 0.0001742874718064 0.0481810705673936 0.0 9754 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +800258 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0086886399052406 0.6332974881236617 0.863034163938375 0.6198216015396206 0.0020251995753771 0.0627102121186242 0.0 0.0 0.0 0.0 18 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +800346 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0086875187881089 0.831981591331937 0.7763400818577846 0.6198216015396206 0.0048935684578858 0.0219439768073448 0.0 0.0055555555555555 0.7627583494613085 0.0 30 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +800568 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0086850455878266 0.6593525851613742 0.8998347793593909 0.6198216015396206 0.018132161410931 0.0064362797035136 0.0 0.0006122948812147 0.2218485321979316 0.0 1361 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +800586 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0086848093656147 0.4648000335061383 0.7769451595923457 0.7204611100467462 0.2966815529783992 0.0005558995075445 0.0 0.001860963916225 0.3519548515983657 0.0 1321 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +800745 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0086829746951877 0.8624864526942296 0.6580560501976399 0.6198216015396206 0.0020100505037262 0.0606066271159369 0.0 0.0 0.0 0.0 10 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +800928 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0086809339740593 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0131302879503246 0.0104714078116759 0.0 0.0001923711113553 0.0161507180951248 0.0 827 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +801002 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0086801217657812 0.7487535481622718 0.7757991160529997 0.9429656149619918 0.0637288077574987 0.0012252690191386 0.0 0.0009348372463679 0.7500871326722651 0.0 2966 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +801138 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0086784187406148 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0053032910137447 0.0244129856070659 0.0 0.00078125 0.0274368089543559 0.0 1280 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +801163 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0086781137400746 0.7745997874735252 0.777821334064334 1.0 0.0065101973396288 0.0108892901157311 0.0 0.0003324191805867 0.0412496199669791 0.0 4011 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +801252 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0086769984388314 0.831981591331937 0.4642836810638544 0.2461374514707439 0.0048935684578858 0.0917308979735958 0.0 0.0 0.0 0.0 41 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +801405 CD34 SELP CD34-SELP CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0086753892660259 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0298399317533219 0.0036702914086929 0.0 0.0002323420074349 0.0950235631693714 0.0 2152 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +801465 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0086746554823514 0.8721681415062816 0.885766439573873 0.9429656149619918 0.0425206505665654 0.0013756087909864 0.0 6.495193556767991e-05 0.0244732996547048 0.0 2566 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +801591 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Macrophages Mast Cells -> Macrophages 0.0086732240656475 0.7487535481622718 0.7754239189773715 0.8567148457705164 0.0016417770622885 0.0521257226458961 0.0 0.0019283746556473 0.0806491691972131 0.0 165 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +801958 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0086686743825217 0.6593525851613742 0.7472387841445823 0.6198216015396206 0.0201572483258557 0.0068935067166085 0.0 0.0072463768115942 0.4406234309194684 0.0 23 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +801993 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0086681947397637 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0033973231723341 0.0416128058995347 0.0 0.0019315673289183 0.0637819269545801 0.0 453 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +802029 C3 LRP1 C3-LRP1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0086678395874307 0.9487258305485792 0.6207977546603366 0.6198216015396206 0.0110943464444434 0.0104714078116759 0.0 0.001412192393736 0.138965780007174 0.0 3576 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +802172 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0086661088539248 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0361307801045652 0.0041555861088636 0.0 0.0018588770864946 0.3531836926220413 0.0 659 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +802242 CD48 CD2 CD48-CD2 B Cells Mast Cells B Cells -> Mast Cells 0.0086652037095873 0.9426443637490616 0.7763428264267787 0.6198216015396206 0.0632786830726401 0.0014748371602574 0.0 0.0 0.0 0.0 97 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +802372 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0086636482612879 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0015847932820241 0.1076178292491983 0.0 0.0020248568635665 0.1696439846118982 0.0 1302 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +802510 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0086620126943598 0.831981591331937 0.9130058539314824 0.8567148457705164 0.0048935684578858 0.0132636308162813 0.0 0.0 0.0 0.0 165 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +802580 VWF ITGA9 VWF-ITGA9 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.008661243820895 0.6332974881236617 0.863034163938375 0.6198216015396206 0.0019871862905238 0.0627102121186242 0.0 0.0012040939193257 0.0096723003158973 0.0 151 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +802598 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0086610377568869 0.4593282471594782 0.8960994285623033 0.2461374514707439 0.0181222899145132 0.0229905310518441 0.0 0.0 0.0 0.0 727 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +803305 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0086523442626662 0.6630837220165452 0.6587114738285964 0.8824495942126559 0.0415873844357376 0.0026174949623928 0.0 0.0002391514905116 0.0233114231177709 0.0 11947 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +803356 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.008651694885082 0.8949858186325867 0.6580560501976399 0.6198216015396206 0.001895566065636 0.0606066271159369 0.0 0.0012919896640826 0.0365818539510413 0.0 129 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +803652 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0086479150049166 0.4630253981438691 0.4630027772793905 0.8293805866303694 0.2545335314555431 0.0009242223287825 0.0 0.0004566210045662 0.0870779855093815 0.0 219 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +803972 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0086439674680257 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0172764782878141 0.0076236123034427 0.0 0.0007141581860382 0.0636451547483279 0.0 1867 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +804249 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.008640569988816 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.141548283585814 0.0076066460958003 0.0 0.0025806451612903 1.0 0.0 155 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +804272 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0086402404858364 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.1932385901170197 0.0007053434767499 0.0 0.0023173391494002 1.0 0.0 917 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +804274 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0086402085362967 0.7745997874735252 0.7472387841445823 0.6198216015396206 0.016822895653248 0.0068935067166085 0.0 0.0009233610341643 0.056145921945417 0.0 361 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +804386 A2M LRP1 A2M-LRP1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0086389491550478 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.0149044683666724 0.0064028969591119 0.0 0.0003767730496453 0.0530429551424546 0.0 1880 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +804624 VWF SELP VWF-SELP CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0086360322970204 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0016171311116606 0.0741032966028748 0.0 0.0002146613716861 0.004951044959337 0.0 2541 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +804705 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0086351397807559 0.6630837220165452 0.6587114738285964 0.8824495942126559 0.0037159398684439 0.0289462771086338 0.0 0.0002126905352711 0.0314343608650969 0.0 12090 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +804818 COL4A1 CD93 COL4A1-CD93 B Cells Macrophages B Cells -> Macrophages 0.008633648344373 0.8684504425765611 0.944024288971064 0.6198216015396206 0.0016831757123532 0.0484215930647349 0.0 0.0001341381623071 0.0045453536058095 0.0 1065 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +804856 VWF LRP1 VWF-LRP1 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0086331493576899 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0025256125075084 0.0350138403862125 0.0 0.0007826844310531 0.0319717199831171 0.0 1931 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +805005 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.008631455268496 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0316800311254893 0.0058437228618857 0.0 0.0005477308294209 0.1662144251341516 0.0 1278 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +805111 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0086301351936131 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.0839650520556947 0.0026174949623928 0.0 0.0030349013657056 0.2958286804121499 0.0 659 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +805547 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.008625268635769 0.7856500335676843 0.9003264838243337 0.7827641335561659 0.0005542667491398 0.1341680150528327 0.0 0.001713796058269 0.0426759631722301 0.0 389 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +805571 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0086249704890281 0.7797302331085993 0.885766439573873 0.6198216015396206 0.0699064461360958 0.0013756087909864 0.0 0.0004508566275924 0.1698786841676444 0.0 1109 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +805581 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0086248307549646 0.8937519114898692 0.9078204025796472 0.9429656149619918 0.0037268694422441 0.0144359394371152 0.0 0.0004612546125461 0.0565894808166391 0.0 2710 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +805647 C3 LRP1 C3-LRP1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0086238924697551 0.6319926036888139 0.6207977546603366 0.909150863993142 0.0691889863216023 0.0016667952436519 0.0 0.0008269720101781 0.1518901680960798 0.0 1572 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +805792 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0086223193907958 0.8730912658940219 0.7754239189773715 0.7204611100467462 0.0057086106530109 0.0147571931436988 0.0 0.0037878787878787 0.0758562654816134 0.0 48 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +805888 C3 LRP1 C3-LRP1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0086209898399237 0.7796725988275006 0.6207977546603366 0.6198216015396206 0.000819605673545 0.166956519448744 0.0 0.00125 0.0175806723956024 0.0 160 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +806173 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0086174646505744 0.2534163760166434 0.6580560501976399 0.2461374514707439 0.0050543892975134 0.1973932010691654 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +806224 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0086168235434232 0.718867305289982 0.7167436199046466 1.0 0.0024319941937022 0.0326667674102811 0.0 0.0065371024734982 0.1306307265940781 0.0 283 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +806352 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.00861521618538 0.8730912658940219 0.4600037439857229 0.8293805866303694 0.0057086106530109 0.0215025911544899 0.0 0.0028058361391694 0.3370810152144695 0.0 324 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +806479 VWF LRP1 VWF-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0086137865377986 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0025256125075084 0.0587195251380622 0.0 0.0001583548933892 0.0164683985840945 0.0 5095 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +806592 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0086123673368038 0.4619393085577573 0.7841656220878274 0.7204611100467462 0.1194227711616854 0.001309307002134 0.0 0.0 0.0 0.0 1321 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +806809 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0086101495421614 0.662063103571249 0.7841656220878274 0.6198216015396206 0.0967042147306326 0.001309307002134 0.0 0.0 0.0 0.0 143 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +806918 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0086086789211836 0.4593282471594782 0.4603649459881741 0.8767341187813953 0.0351142257737683 0.0062523288579129 0.0 0.000203832042397 0.0024091459230054 0.0 2453 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +807115 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0086062084981827 0.7487535481622718 0.4596166826058663 0.2461374514707439 0.0637288077574987 0.0075270071967493 0.0 0.000523834468308 0.2312384419392652 0.0 1909 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +807258 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0086044306606989 0.6160088550075702 0.9460955677032749 0.8693461273411047 0.0021291294377375 0.0376195773145198 0.0 0.0008417508417508 0.0306261096586874 0.0 270 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +807351 VEGFC FLT1 VEGFC-FLT1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0086031884633471 0.8963332422588541 0.4630488285702799 0.7204611100467462 0.0026007495851186 0.0521374123931907 0.0 0.0003417401407969 0.0607983861299283 0.0 9754 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +807402 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0086026384677397 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0338862305197021 0.0038860320327025 0.0 0.000352360817477 0.1993231678517731 0.0 129 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +807564 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0086009813124135 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0149256517769723 0.0091569531245039 0.0 0.0012751713511503 0.3337711838751496 0.0 1711 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +807640 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0085999349593867 0.6659645551150886 0.8960994285623033 0.7917001487310438 0.0037243679732516 0.0229905310518441 0.0 0.0 0.0 0.0 193 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +807702 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0085991182590257 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0323110954490285 0.0032875740549697 0.0 0.0043620501635768 0.7038385356353931 0.0 262 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +807729 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.008598828808826 0.4593282471594782 0.4603649459881741 1.0 0.0181222899145132 0.0105486447632276 0.0 0.0002064649332214 0.038348804945635 0.0 77495 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +807917 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.008596465322324 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.0084325366891025 0.0118035014556376 0.0 0.0 0.0 0.0 69 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +808131 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0085937278121047 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0338862305197021 0.0038621268649178 0.0 0.0 0.0 0.0 129 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +808334 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0085912490148368 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0021291294377375 0.1076178292491983 0.0 0.0004545454545454 0.0380821496490847 0.0 800 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +808426 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Macrophages Mast Cells -> Macrophages 0.0085899696910736 0.7487535481622718 0.7757991160529997 0.8567148457705164 0.0016417770622885 0.0491709261488903 0.0 0.0049586776859504 0.2237726008407347 0.0 165 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +808460 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0085894864269356 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0106340017102282 0.0215025911544899 0.0 5.282341133590407e-05 0.0063459761144385 0.0 5163 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +808503 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0085890279722626 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0071496754272206 0.0203874717835032 0.0 0.0001768659356207 0.0082813526404238 0.0 1542 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +808573 C3 LRP1 C3-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0085882604687681 0.6319926036888139 0.6207977546603366 0.9161861017439124 0.0616816618657801 0.0018097844702233 0.0 0.0005434782608695 0.1919184869844371 0.0 460 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +808608 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0085878579041435 0.4629984640915818 0.8755243548400705 0.7204611100467462 0.3309594876493178 0.0004150165744076 0.0 0.001514684740193 0.210535330683205 0.0 1082 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +808900 CD34 SELP CD34-SELP Mast Cells Pericytes Mast Cells -> Pericytes 0.0085844857289197 0.8532069650852002 0.8819126042133903 0.8567148457705164 0.00083777361258 0.0741032966028748 0.0 0.0 0.0 0.0 244 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +809111 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0085819056622505 0.6301823358791634 0.6347970925105053 1.0 0.0172764782878141 0.0057802287131517 0.0 0.0001532488761749 0.0263648610590929 0.0 19576 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +809113 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0085818898611595 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0015572459193676 0.0741032966028748 0.0 0.0001199328376109 0.0027661840900781 0.0 379 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +809177 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0085811184635031 0.8624864526942296 0.4638256179742202 0.7204611100467462 0.0020100505037262 0.0689186266365139 0.0 0.0006404098623118 0.0780325261486459 0.0 1041 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +809178 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0085811162213914 0.7840818683779507 0.4641352222874551 0.7204611100467462 0.0032417203409647 0.046975263367762 0.0 0.0007680491551459 0.1270655498997524 0.0 1302 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +809232 THBS2 CD36 THBS2-CD36 Endothelial Cells 11q13 Invasive Tumor Cells Endothelial Cells -> 11q13 Invasive Tumor Cells 0.0085804165401393 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0039472834455595 0.02871400543887 0.0 9.023266144705425e-05 0.0436649541460181 0.0 6003 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +809328 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0085794985699302 0.8684504425765611 0.7779918296243433 0.8693461273411047 0.0126216524880575 0.0053794918117879 0.0 9.691800736576855e-05 0.0078877706565428 0.0 737 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +809399 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.008578585740044 0.6213271600240247 0.8617632615906476 0.6198216015396206 0.1153131738111426 0.0010414441948928 0.0 0.0 0.0 0.0 18 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +809482 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0085776547588412 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0215813276111062 0.0045642085393754 0.0 0.0008598452278589 0.0985480983174122 0.0 1163 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +809497 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0085774022948808 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.1928969878996252 0.0009242223287825 0.0 0.0037974683544303 0.7241802086033374 0.0 79 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +809746 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0085740641739995 0.8349903778527206 0.8604147465201248 0.8567148457705164 0.0014804857410621 0.0436001007095475 0.0 0.0042087542087542 0.0967201698538456 0.0 165 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +809973 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0085711811096484 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0025256125075084 0.0565946652887153 0.0 0.0005820044232336 0.0215285014104544 0.0 1562 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +810036 VWF LRP1 VWF-LRP1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0085703768815944 0.9275752708651288 0.7769451595923457 0.7827641335561659 0.1263644540569636 0.0005558995075445 0.0 0.00352416570771 0.4415234181679137 0.0 316 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +810166 HSPG2 LRP1 HSPG2-LRP1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0085689086380105 0.9253089325030373 0.6207977546603366 0.6198216015396206 0.0022161183602947 0.0501711964086628 0.0 0.0006092340117236 0.0103369397192148 0.0 1687 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +810420 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0085656794165833 0.662063103571249 0.6331674633943454 0.9592803095773328 0.0236359933700329 0.0041555861088636 0.0 0.0007198509485094 0.0914205698820331 0.0 1476 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +810474 THBS2 CD36 THBS2-CD36 Endothelial Cells Dendritic Cells Endothelial Cells -> Dendritic Cells 0.0085650534752057 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0039472834455595 0.0284069116891947 0.0 0.0006283380458686 0.0520479930139828 0.0 2122 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +810991 COL4A2 CD93 COL4A2-CD93 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0085586045368868 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0033449520260795 0.0289462771086338 0.0 0.0001254705144291 0.0267124810070337 0.0 797 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +811012 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0085584068309722 0.831981591331937 0.885766439573873 0.8567148457705164 0.0048935684578858 0.0127192475389894 0.0 0.0006830601092896 0.1030222244720228 0.0 244 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +811039 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0085580894516367 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.1357656553382984 0.0007400708115376 0.0 0.0002687016337059 0.0524480373591404 0.0 1163 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +811366 CD48 CD2 CD48-CD2 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0085545900903749 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0212837736082081 0.0071918009517169 0.0 0.0 0.0 0.0 715 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +811438 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0085538576904153 0.4636527906642655 0.7472387841445823 0.2461374514707439 0.0666348171285698 0.0068935067166085 0.0 0.0 0.0 0.0 84 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +811723 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0085502055833607 0.8949858186325867 0.4638256179742202 0.7204611100467462 0.001895566065636 0.0689186266365139 0.0 0.0001879570774383 0.0176761581324476 0.0 9754 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +811889 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0085482697530457 0.8640667164982425 0.7167436199046466 0.7204611100467462 0.002676946692949 0.0326667674102811 0.0 0.0 0.0 0.0 285 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +811994 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0085469925077381 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0072827533047186 0.0144359394371152 0.0 0.0015015015015015 0.1313915607972091 0.0 370 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +812053 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0085463303923881 0.9219165193585238 0.62431395375366 0.6198216015396206 0.0086134406931133 0.0126805820762719 0.0 0.0003367003367003 0.0685944727648302 0.0 1881 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +812262 C3 LRP1 C3-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0085437433608157 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0691889863216023 0.0018097844702233 0.0 0.0022727272727272 0.8025682182985557 0.0 209 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +812320 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0085429918743873 0.7451589345683471 0.6331674633943454 0.6198216015396206 0.0040724665904272 0.0326412663903893 0.0 0.0004874350086655 0.1660386709388675 0.0 1154 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +812601 THBS2 CD36 THBS2-CD36 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.008539524699574 0.724503440376099 0.8587566561291643 0.7204611100467462 0.0009736808737186 0.088850508457521 0.0 0.0016073194856577 0.0313914397508232 0.0 337 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +812911 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0085358262032461 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.011891719340537 0.0104714078116759 0.0 0.0001511487303506 0.0148736824411763 0.0 827 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +812984 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.008534994596093 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0149256517769723 0.0080072638027924 0.0 0.0008285483062931 0.2001365526381062 0.0 2359 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +813183 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0085324315665525 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0236359933700329 0.0049190726392343 0.0 0.0 0.0 0.0 38 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +813390 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0085300385007125 0.7856500335676843 0.8817184225858201 0.7827641335561659 0.0005542667491398 0.1281708518900828 0.0 0.0019280205655526 0.0398192657226356 0.0 389 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +813648 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0085271133816921 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0491302556793708 0.0023576674662702 0.0 0.0005747126436781 0.1784105978248572 0.0 1305 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +813864 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.008524800921815 0.6160088550075702 0.8628183098412396 1.0 0.0021291294377375 0.0339152418223636 0.0 0.0003715124270906 0.0283844068858119 0.0 19576 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +813894 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0085244219117811 0.6593525851613742 0.6593689120110077 0.9592803095773328 0.0201572483258557 0.0045642085393754 0.0 0.0002229654403567 0.0255543898201004 0.0 1495 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +813895 VWF ITGA9 VWF-ITGA9 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0085244141623563 0.6332974881236617 0.6252253442669611 1.0 0.0019871862905238 0.0487643047611538 0.0 0.0004079689943564 0.0159690700234843 0.0 4011 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +814085 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0085220932502129 0.6303642896310324 0.6331674633943454 0.9161861017439124 0.141548283585814 0.0007400708115376 0.0 0.0010326086956521 0.2379686915415139 0.0 460 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +814205 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0085206608962928 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0491302556793708 0.0026482500471321 0.0 0.0001750700280112 0.0653275582527243 0.0 714 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +814231 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells 0.0085204060956649 0.6242573126045354 0.6176321640000088 1.0 0.0034559943126159 0.02871400543887 0.0 1.7897207878232926e-05 0.0086607304806513 0.0 423716 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +814290 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0085197316704879 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0208904415011529 0.0057802287131517 0.0 0.0002467105263157 0.042443957244474 0.0 30400 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +814518 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0085170477572916 0.6593525851613742 0.7472387841445823 0.6198216015396206 0.018132161410931 0.0068935067166085 0.0 0.0023310023310023 0.1417390057503185 0.0 143 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +814689 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0085149520936974 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0012814156885439 0.166956519448744 0.0 0.0073099415204678 0.041007839907834 0.0 285 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +814699 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0085148441516203 0.4619393085577573 0.9015117569158254 0.7204611100467462 0.0051428381563772 0.0246995741084876 0.0 0.0014836795252225 0.1429573055913485 0.0 337 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +814839 A2M LRP1 A2M-LRP1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0085131866461809 0.919551140852988 0.6207977546603366 0.6198216015396206 0.037376181609614 0.0028784826949613 0.0 0.0003229974160206 0.0522107005487489 0.0 129 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +815218 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0085082591999848 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0186793449598515 0.0069630688870869 0.0 0.0 0.0 0.0 1673 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +815273 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0085075579420086 0.7840818683779507 0.4638256179742202 0.7204611100467462 0.0032417203409647 0.0446401662952339 0.0 0.0 0.0 0.0 85 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +815283 MMP2 PECAM1 MMP2-PECAM1 Pericytes B Cells Pericytes -> B Cells 0.0085074606801936 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0216588811659259 0.0049190726392343 0.0 0.0011523988711194 0.1407669429940779 0.0 1063 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +815870 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0084999641701255 0.8533682807143209 0.8347945881127203 0.6198216015396206 0.0706049302656684 0.0012097093680331 0.0 0.0 0.0 0.0 18 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +816268 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0084949769776454 0.7840818683779507 0.6580560501976399 0.6198216015396206 0.0032417203409647 0.0362497659817488 0.0 0.0 0.0 0.0 32 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +816292 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0084946985043245 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.000393370777602 0.287457858136305 0.0 0.0005496921723834 0.016718073626075 0.0 379 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +816306 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0084945659134935 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.0070489045197697 0.0144359394371152 0.0 0.0004770992366412 0.0585333942798061 0.0 262 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +816390 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0084935534852562 0.7487535481622718 0.7754239189773715 0.7827641335561659 0.0015847932820241 0.0521257226458961 0.0 0.005050505050505 0.2112240145641295 0.0 162 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +817003 CCN1 CAV1 CCN1-CAV1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0084862103482399 0.6213271600240247 0.62431395375366 0.909150863993142 0.0083518627398662 0.0126805820762719 0.0 0.0002364465461915 0.0481702107340253 0.0 5921 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +817273 CD34 SELP CD34-SELP CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0084828504047171 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0298399317533219 0.0032078747392388 0.0 0.0002137665669089 0.048938582194107 0.0 2339 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +817368 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Pericytes Mast Cells -> Pericytes 0.0084817060625154 0.8571898293845529 0.9003264838243337 0.8567148457705164 0.0004196880356983 0.1341680150528327 0.0 0.0040983606557377 0.1020550184876898 0.0 244 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +817811 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0084762951322642 0.6249837837987587 0.7470475610360806 0.6198216015396206 0.1661175896787547 0.0007714919761827 0.0 0.0032299741602067 0.4959620306093189 0.0 129 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +817825 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0084760715374705 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0083898580598364 0.0083242517891534 0.0 0.0015320910973084 0.1792335642362575 0.0 2300 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +817997 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes B Cells Pericytes -> B Cells 0.0084740586557123 0.9184503888425788 0.7746834992804791 0.6198216015396206 0.1169448695751571 0.00071798405859 0.0 0.0009407337723424 0.4971060574721916 0.0 1063 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +818031 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0084734812269767 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0020251995753771 0.0587195251380622 0.0 0.0001447860475891 0.0150572823490345 0.0 30217 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +818130 VWF ITGA9 VWF-ITGA9 Macrophages Mast Cells Macrophages -> Mast Cells 0.0084721037728046 0.9011206516381156 0.863034163938375 0.8567148457705164 0.0008850282134344 0.0627102121186242 0.0 0.0011019283746556 0.0088516202890939 0.0 165 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +818787 COL4A2 CD93 COL4A2-CD93 Mast Cells Macrophages Mast Cells -> Macrophages 0.0084641820111053 0.8355319038299565 0.944024288971064 0.8567148457705164 0.001123788079051 0.0484215930647349 0.0 0.0006060606060606 0.0224578616873196 0.0 165 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +819062 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0084609282264575 0.4625081978296446 0.7467524951532132 0.7204611100467462 0.0141498126994191 0.0104195741475089 0.0 0.003875968992248 0.2674418604651163 0.0 43 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +819088 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0084606595016353 0.6589792304505506 0.6207977546603366 0.8824495942126559 0.0561415215593491 0.0018097844702233 0.0 0.0002773155851358 0.0246717432044496 0.0 12020 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +819249 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0084588543644443 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0104129581710415 0.0125623889131764 0.0 0.00015625 0.0503325015995933 0.0 800 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +819483 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0084560308419742 0.6160088550075702 0.8950084308969304 0.7917001487310438 0.0001971810371238 0.4247538686915498 0.0 0.0 0.0 0.0 193 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +819546 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0084552823083231 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0093830613230477 0.0126805820762719 0.0 0.0032128514056224 0.6545400292740429 0.0 83 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +819699 VWF LRP1 VWF-LRP1 Pericytes Mast Cells Pericytes -> Mast Cells 0.0084532898607072 0.9275752708651288 0.8755243548400705 0.8567148457705164 0.1263644540569636 0.0004150165744076 0.0 0.0023232323232323 0.2842489031699934 0.0 225 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +819800 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0084520588004641 0.4630253981438691 0.4630027772793905 0.2461374514707439 0.0443339118517084 0.0155837683010033 0.0 0.0003074400491904 0.0849905650231528 0.0 4879 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +820220 VWF LRP1 VWF-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0084467635578216 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0019871862905238 0.0587195251380622 0.0 0.0002678880055305 0.0278594892557682 0.0 3945 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +820454 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0084439256290978 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0186793449598515 0.0042655619249233 0.0 4.3572984749455335e-05 0.0094643268178183 0.0 11475 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +820493 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0084436062902503 0.6332974881236617 0.6252253442669611 1.0 0.0016171311116606 0.0565946652887153 0.0 0.0003604098374723 0.0133316576036572 0.0 5297 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +820966 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0084382405475284 0.4648000335061383 0.8755243548400705 0.7204611100467462 0.2966815529783992 0.0004150165744076 0.0 0.0015403573629081 0.2240519800593738 0.0 1082 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +821173 C1QB LRP1 C1QB-LRP1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0084357894572032 0.8703788833238396 0.6207977546603366 0.8693461273411047 0.0037630364713574 0.0203874717835032 0.0 0.0005208333333333 0.0294950075652522 0.0 360 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +821188 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.008435642636466 0.7475533330314548 0.657421674383923 0.6198216015396206 0.0029751676683741 0.0397596998227057 0.0 0.0 0.0 0.0 30 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +821309 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0084343270062538 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0028649117803088 0.0689186266365139 0.0 0.0003996802557953 0.0375873656908423 0.0 3336 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +821536 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0084315697756059 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0020251995753771 0.0565946652887153 0.0 0.0003895408287481 0.0144092208690433 0.0 1867 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +821653 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0084302362620683 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.2159908053119969 0.0009249287638231 0.0 0.0 0.0 0.0 103 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +821984 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0084262659539423 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.00146889578236 0.0627790816848129 0.0 0.0017101325352714 0.0374487588367263 0.0 2339 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +821985 VEGFC FLT1 VEGFC-FLT1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0084262412597774 0.8963332422588541 0.777821334064334 0.6198216015396206 0.0026007495851186 0.0318483483218543 0.0 0.000186428038777 0.0235927422727992 0.0 3576 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +822247 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0084231083402507 0.7789175740361626 0.6207977546603366 1.0 0.0070532058552773 0.0104714078116759 0.0 0.000318216104092 0.0265987202250225 0.0 21212 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +822322 CD34 SELP CD34-SELP CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0084221691633954 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.1173076386135379 0.0010419094417808 0.0 0.0 0.0 0.0 135 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +822536 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0084196004539118 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0244483651952677 0.0042655619249233 0.0 0.0007374631268436 0.1867538805833388 0.0 339 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +822601 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0084187146306898 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0024319941937022 0.0518891167572028 0.0 0.0050738007380073 0.1852483292873078 0.0 271 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +823155 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.008412023770588 0.7487535481622718 0.7757991160529997 0.7827641335561659 0.0015847932820241 0.0491709261488903 0.0 0.0030864197530864 0.1392823287125972 0.0 162 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +823167 C3 LRP1 C3-LRP1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0084119214795043 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0334108479684367 0.0267255153180908 0.0 0.0009791122715404 0.1550184160600321 0.0 383 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +823386 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0084090017150753 0.4636527906642655 0.777821334064334 0.6198216015396206 0.014525360548861 0.0108892901157311 0.0 0.0008565834557023 0.106292729424823 0.0 1362 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +823441 CD48 CD2 CD48-CD2 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0084083059658212 0.9426443637490616 0.7464347811605867 0.6198216015396206 0.0632786830726401 0.0012805120781881 0.0 0.0036496350364963 0.8859156243566613 0.0 137 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +823657 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0084059525524256 0.6160088550075702 0.7462743270426613 0.6198216015396206 0.0548063857429699 0.0022591041672132 0.0 0.0076287349014621 0.8476941391130404 0.0 143 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +823725 VWF ITGA9 VWF-ITGA9 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0084049842571291 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0019871862905238 0.0565946652887153 0.0 0.000308297044202 0.0114039912515912 0.0 2359 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +823808 C1QB LRP1 C1QB-LRP1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0084037948858753 0.8703788833238396 0.6207977546603366 0.9318789094584046 0.0419710388788557 0.0016667952436519 0.0 0.0002245508982035 0.0394706371874734 0.0 5010 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +824002 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0084013116544031 0.2542249848376565 0.943345641464811 0.2461374514707439 0.1711385759005754 0.0034806998160403 0.0 0.0002408477842003 0.0891637039365469 0.0 1384 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +824335 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0083971423589157 0.8023917560710954 0.7757991160529997 0.7204611100467462 0.0085367158000785 0.0091569531245039 0.0 0.0002118544324655 0.0554520807493249 0.0 1931 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +824340 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0083970819422736 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0683610513379333 0.0028784826949613 0.0 0.0036460967796324 0.2695946690040549 0.0 659 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +824460 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0083957246226596 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0012306151710811 0.0826982152707935 0.0 0.0 0.0 0.0 126 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +824466 CCN1 CAV1 CCN1-CAV1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0083956665122687 0.6213271600240247 0.62431395375366 0.7917001487310438 0.013905026986541 0.0082011408892332 0.0 0.0 0.0 0.0 97 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +824580 A2M LRP1 A2M-LRP1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0083943527920082 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.0015661096645571 0.0587195251380622 0.0 0.0001568381430363 0.0201663415112119 0.0 797 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +824733 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0083924013024438 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.2545335314555431 0.0007261054236978 0.0 0.0028436018957345 0.4367087278758743 0.0 422 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +824769 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0083920016757672 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0267593032157803 0.0058437228618857 0.0 0.0012747875354107 0.3868470898205207 0.0 1412 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +824772 C1QB LRP1 C1QB-LRP1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.008391990588542 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0111808254589153 0.0104714078116759 0.0 0.0008092442035531 0.0809371946713213 0.0 3321 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +824856 VWF LRP1 VWF-LRP1 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0083908526448221 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0025256125075084 0.0501711964086628 0.0 0.0004839140301695 0.0098102111771526 0.0 1362 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +825295 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0083852512814264 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0213929720256037 0.0041555861088636 0.0 0.0 0.0 0.0 97 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +825403 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0083840016868343 0.9184503888425788 0.6580560501976399 0.6198216015396206 0.0004696576149175 0.1973932010691654 0.0 0.0011720581340834 0.0209771752326819 0.0 1422 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +825415 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0083838955741591 0.6332974881236617 0.6207977546603366 0.8693461273411047 0.0020251995753771 0.0501711964086628 0.0 0.0006421978404737 0.0130190406555296 0.0 1044 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +825701 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0083802456564746 0.7741139100414175 0.7769451595923457 0.6198216015396206 0.1671376945154473 0.0005558995075445 0.0 0.0025839793281653 0.4886951611735026 0.0 129 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +825789 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0083791944589792 0.9275752708651288 0.7292496872084557 0.7204611100467462 0.000245041593909 0.2898144908728011 0.0 9.650646593321752e-05 0.0022413471459247 0.0 1884 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +826122 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0083754254059031 0.7789175740361626 0.6207977546603366 0.8693461273411047 0.0492631209980634 0.0016667952436519 0.0 0.0011831275720164 0.1496833454300814 0.0 270 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +826203 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0083744578859329 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0411127335336962 0.0023576674662702 0.0 0.0017884322678843 0.8575590175990474 0.0 1971 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +826286 C3 LRP1 C3-LRP1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.008373436091564 0.8509500867818902 0.6207977546603366 0.6198216015396206 0.0006305085967044 0.166956519448744 0.0 0.0032986111111111 0.0463934410439509 0.0 144 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +826531 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0083703726666449 0.9275752708651288 0.7292496872084557 0.7204611100467462 0.000245041593909 0.2879885658616873 0.0 4.976321005880352e-05 0.0018338537243973 0.0 10961 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +826577 VWF ITGA9 VWF-ITGA9 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0083698826585057 0.9011206516381156 0.6252253442669611 0.6198216015396206 0.0008850282134344 0.1112417752963437 0.0 0.0 0.0 0.0 1739 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +826601 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells CAFs, DCIS Associated 11q13 Invasive Tumor Cells -> CAFs, DCIS Associated 0.0083694673372259 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0097699360831605 0.0125623889131764 0.0 0.0001109701965757 0.0357466086186078 0.0 1577 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +826643 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0083688308408149 0.6332974881236617 0.863034163938375 0.6198216015396206 0.0016171311116606 0.0627102121186242 0.0 0.002097902097902 0.016852123242698 0.0 130 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +826651 CD48 CD2 CD48-CD2 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0083687659222503 0.7719609236370527 0.8581827408615759 0.6198216015396206 0.0212837736082081 0.003930762149527 0.0 0.0 0.0 0.0 594 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +826677 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0083684421681088 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0131302879503246 0.0083442542366581 0.0 0.0003189792663476 0.0175591394261521 0.0 570 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +826736 A2M LRP1 A2M-LRP1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0083678087338438 0.7741139100414175 0.6207977546603366 0.909150863993142 0.0015661096645571 0.0501711964086628 0.0 0.0016677426296535 0.0448255025030003 0.0 1549 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +826783 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0083671760083505 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0028649117803088 0.0362497659817488 0.0 0.0007974481658692 0.0334444748529929 0.0 209 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +826915 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0083655072344937 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0021291294377375 0.049767778498468 0.0 9.025623745814364e-05 0.0308446605818052 0.0 30217 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +827120 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0083628950806957 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0151307911035231 0.0079745943515326 0.0 0.0004574565416285 0.0548137826981855 0.0 1093 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +827276 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0083610681648651 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0025256125075084 0.0487643047611538 0.0 0.000934454678948 0.0365772213288766 0.0 1362 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +827381 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0083598120159257 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0208904415011529 0.0058465532256424 0.0 0.0002259668151591 0.0475586165973224 0.0 5163 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +827613 CD48 CD2 CD48-CD2 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0083573112809359 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0212837736082081 0.0062523288579129 0.0 0.0 0.0 0.0 326 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +827618 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0083572644309716 0.7800321422220979 0.6331674633943454 0.909150863993142 0.0014623066995027 0.0518891167572028 0.0 4.034861200774693e-05 0.0020650963720685 0.0 1549 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +827717 C3 LRP1 C3-LRP1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0083560497099914 0.7148920381722296 0.9078204025796472 0.7204611100467462 0.005043231651446 0.0144359394371152 0.0 0.0002670226969292 0.0456007197076828 0.0 2247 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +827801 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0083551060478987 0.8913986641324685 0.6331674633943454 0.6198216015396206 0.0054950348959687 0.0176963220730796 0.0 0.0002446868008948 0.0447298479267953 0.0 3576 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +827880 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0083541357892767 0.6332974881236617 0.6252253442669611 0.8693461273411047 0.0020251995753771 0.0487643047611538 0.0 0.0002612330198537 0.0102254054700184 0.0 1044 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +828143 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0083511728924968 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0048525806497539 0.0203874717835032 0.0 0.0003003003003003 0.0384118420509106 0.0 1332 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +828228 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0083500451650983 0.6626993710110988 0.6207977546603366 0.8824495942126559 0.0515877972474039 0.0018097844702233 0.0 0.0001663893510815 0.0183565773693065 0.0 12020 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +828588 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0083458867633587 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.000716220684292 0.1341680150528327 0.0 0.002415458937198 0.060148368384049 0.0 345 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +828740 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0083439684348037 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.0142750905665976 0.0064028969591119 0.0 0.0003687315634218 0.0519108566724698 0.0 339 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +828815 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0083429913201972 0.4593282471594782 0.8581827408615759 0.6198216015396206 0.0351142257737683 0.003930762149527 0.0 0.0 0.0 0.0 1542 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +828822 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0083428803023174 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0083565457974945 0.0222228052993653 0.0 0.0 0.0 0.0 157 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +828949 CD48 CD2 CD48-CD2 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0083413174838977 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0467114894617178 0.0038288178384739 0.0 0.0 0.0 0.0 3 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +829009 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0083405391504473 0.8349903778527206 0.9078204025796472 0.8567148457705164 0.0014804857410621 0.0350138403862125 0.0 0.0038706739526411 0.1657075521928059 0.0 244 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +829019 COL4A2 CD93 COL4A2-CD93 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0083403541438177 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0316800311254893 0.0026174949623928 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +829130 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.008338841872615 0.6582846571368821 0.6587114738285964 0.9161861017439124 0.0198024073017111 0.0042738820064046 0.0 0.0017467248908296 0.1486031239988932 0.0 458 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +829210 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0083379657566687 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0065101973396288 0.0232163927704059 0.0 0.0008262511803588 0.1616692267544842 0.0 1412 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +829227 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0083377804984819 0.8533682807143209 0.4630027772793905 0.2461374514707439 0.0706049302656684 0.0048929293424311 0.0 0.0003257859586251 0.0876667411428315 0.0 877 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +829519 C1QB LRP1 C1QB-LRP1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0083342701920548 0.4601010570874773 0.8604147465201248 0.7204611100467462 0.0026949121497638 0.0436001007095475 0.0 0.0077893175074183 0.1826149663107694 0.0 337 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +829529 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0083341280911256 0.4636527906642655 0.6593689120110077 0.2461374514707439 0.0666348171285698 0.0066828239855783 0.0 0.0 0.0 0.0 147 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +829625 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0083330690983141 0.7487535481622718 0.7462743270426613 0.7827641335561659 0.0338862305197021 0.0022591041672132 0.0 0.0030472320975114 0.3386040835004602 0.0 179 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +830315 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0083249129657247 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0131302879503246 0.0642389143033604 0.0 0.000494071146245 0.0231244355408866 0.0 184 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +830328 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0083247411742476 0.6342079770588467 0.4638256179742202 0.2461374514707439 0.000895875398841 0.5131068416842878 0.0 0.0 0.0 0.0 19 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +830549 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0083221561621919 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.0085570823799139 0.009971631136135 0.0 0.0 0.0 0.0 209 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +830619 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0083211981694968 0.9184503888425788 0.4638256179742202 0.7204611100467462 0.1169448695751571 0.0009249287638231 0.0 0.0 0.0 0.0 394 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +830638 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0083210241817699 0.7463064942968751 0.944024288971064 0.7827641335561659 0.0012430446376512 0.0484215930647349 0.0 0.0022045855379188 0.0747037282436284 0.0 162 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +831011 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0083163635883261 0.6332974881236617 0.863034163938375 0.6198216015396206 0.0015572459193676 0.0627102121186242 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +831288 C3 LRP1 C3-LRP1 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0083127246298818 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0091898156146168 0.0104714078116759 0.0 0.0007302017464619 0.0718549793284386 0.0 3321 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +831406 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0083114033191981 0.6593525851613742 0.6593689120110077 0.9161861017439124 0.018132161410931 0.0045642085393754 0.0 0.0 0.0 0.0 460 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +831431 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0083112038961388 0.6342079770588467 0.7754072541855492 0.909150863993142 0.0073929685753755 0.009971631136135 0.0 0.0008674531575294 0.1053251598197657 0.0 5764 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +831485 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0083105492211156 0.6332974881236617 0.6207977546603366 0.8824495942126559 0.0016171311116606 0.0587195251380622 0.0 0.0001994306450603 0.0207401443835679 0.0 5812 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +831499 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.008310404904632 0.6249837837987587 0.7746834992804791 0.909150863993142 0.0161757332769496 0.0046263543438723 0.0 0.0001266677926026 0.0445593450638985 0.0 5921 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +831795 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0083069486416207 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0021291294377375 0.0521257226458961 0.0 0.0010526315789473 0.0440235314565238 0.0 475 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +831820 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0083065978084003 0.6659645551150886 0.6614977577544194 0.8824495942126559 0.0037243679732516 0.0226890201466244 0.0 0.0003308519437551 0.0479537087347091 0.0 12090 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +831964 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0083048739118845 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0361307801045652 0.0032187363284526 0.0 0.0012163892445582 0.3538921810554635 0.0 1562 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +832027 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0083041123677642 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0170183763647696 0.0064028969591119 0.0 0.0007314694408322 0.0751960134710679 0.0 1538 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +832314 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0083004911674163 0.6301823358791634 0.6587114738285964 0.8824495942126559 0.0208904415011529 0.0042738820064046 0.0 0.000535217298223 0.0683223330904722 0.0 4671 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +832326 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0083003935835603 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0151307911035231 0.0076236123034427 0.0 0.0007469056764831 0.0665635825388842 0.0 1562 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +832345 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0083002308959142 0.6301823358791634 0.6347970925105053 0.8824495942126559 0.0208904415011529 0.0044340558155446 0.0 0.000237158561424 0.0309267693785195 0.0 11947 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +832353 MMRN2 CD93 MMRN2-CD93 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0083001559838578 0.9468422434493456 0.4630027772793905 0.7204611100467462 0.1120119983652299 0.0009242223287825 0.0 0.0012690355329949 0.1260581303504896 0.0 394 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +832403 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0082994122518119 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0799339500711946 0.0022515473538965 0.0 0.0048543689320388 0.4035244540927088 0.0 103 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +832489 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0082984441561978 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0093830613230477 0.0124087765732037 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +832642 DLL1 NOTCH3 DLL1-NOTCH3 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0082967359912218 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.00263399584678 0.0689186266365139 0.0 0.0003874072261642 0.0472047141758645 0.0 4087 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +832772 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0082949526239588 0.6593525851613742 0.4630488285702799 0.2461374514707439 0.0120646829101097 0.0359289752254096 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +832888 COL4A1 CD93 COL4A1-CD93 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0082938009417776 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0168149984327668 0.0042738820064046 0.0 0.0010597710894446 0.0765934978103981 0.0 2359 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +833089 C1QB LRP1 C1QB-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0082914989702759 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.0419710388788557 0.0018097844702233 0.0 0.0030864197530864 0.3405031789800385 0.0 81 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +833383 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0082878184105854 0.6589792304505506 0.7769451595923457 0.6198216015396206 0.1836996873148393 0.0005558995075445 0.0 0.0033022533022533 0.4880378626448116 0.0 143 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +833439 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0082871199273541 0.8516956437178343 0.6580560501976399 0.6198216015396206 0.000472352586488 0.1973932010691654 0.0 0.0 0.0 0.0 144 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +833566 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0082857372505414 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0135527119637784 0.0064028969591119 0.0 0.0005033557046979 0.0517456235876968 0.0 1490 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +833743 CD48 CD2 CD48-CD2 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0082837754852205 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0112468593062777 0.0112209532878862 0.0 0.0014409221902017 0.2831154081469651 0.0 1041 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +833758 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0082836237394565 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0131092554497256 0.0080072638027924 0.0 0.0002876869965477 0.069491040281615 0.0 1422 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +834341 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0082766588009976 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0255753403203798 0.0038860320327025 0.0 0.0 0.0 0.0 81 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +834456 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0082753138476947 0.6593525851613742 0.6593689120110077 0.9161861017439124 0.0120646829101097 0.0066828239855783 0.0 0.0004084967320261 0.050316855367111 0.0 408 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +834541 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0082744150841955 0.7468485855611411 0.6207977546603366 0.6198216015396206 0.0006689050756654 0.166956519448744 0.0 0.0034722222222222 0.0194787239562211 0.0 160 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +834776 MMP2 PECAM1 MMP2-PECAM1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0082716373568281 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0216588811659259 0.0041555861088636 0.0 0.0008793969849246 0.1670840297472542 0.0 398 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +834968 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0082691449249501 0.6332974881236617 0.6252253442669611 0.9161861017439124 0.0015572459193676 0.0565946652887153 0.0 0.001389440254069 0.0513957717078403 0.0 458 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +835059 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0082680857967198 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0255753403203798 0.0038621268649178 0.0 0.0 0.0 0.0 97 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +835110 C3 LRP1 C3-LRP1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0082675591794209 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0616816618657801 0.0016667952436519 0.0 0.0025899672846237 0.4756999770042061 0.0 917 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +835307 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0082649998461021 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0078992851324392 0.0222228052993653 0.0 0.0 0.0 0.0 800 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +835365 CD48 CD2 CD48-CD2 Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0082642627167778 0.4593282471594782 0.4603649459881741 0.8293805866303694 0.0161888123016941 0.0112209532878862 0.0 0.0001389467833819 0.0273005548497976 0.0 7197 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +835508 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0082624490334506 0.9219165193585238 0.8818704453527788 0.8875000050982297 0.0086134406931133 0.0051192928876727 0.0 0.0003043071161048 0.0573298537840414 0.0 1424 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +835672 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0082606654371867 0.8913986641324685 0.7167436199046466 0.7204611100467462 0.0054950348959687 0.0125623889131764 0.0 0.0001473754357186 0.068424038665666 0.0 9754 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +835866 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0082584473573548 0.6332974881236617 0.6207977546603366 0.8824495942126559 0.0015572459193676 0.0587195251380622 0.0 0.0001887522443674 0.0196296251246588 0.0 12101 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +835919 C3 LRP1 C3-LRP1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0082576977703813 0.8911088195487638 0.9078204025796472 0.9429656149619918 0.0064915662046245 0.0064028969591119 0.0 0.0004091971940763 0.077524058207778 0.0 2566 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +836136 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.008254847225833 0.6160088550075702 0.4600037439857229 0.2461374514707439 0.0255753403203798 0.017738069381683 0.0 0.0002373605506764 0.0591763825095389 0.0 383 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +836235 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0082537412363957 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.000716220684292 0.1281708518900828 0.0 0.0057971014492753 0.1197271062114417 0.0 345 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +836487 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.008250855753039 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0170183763647696 0.0104714078116759 0.0 0.0003430924062214 0.0343146565037713 0.0 1093 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +836790 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0082472198288676 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0272543760657653 0.0032875740549697 0.0 0.0022781698349121 0.3675940579322585 0.0 2247 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +836800 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0082471315565893 0.7475533330314548 0.7763400818577846 0.6198216015396206 0.0029751676683741 0.0293997450046583 0.0 0.0009803921568627 0.0604452838310114 0.0 170 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +836870 MMRN2 CD93 MMRN2-CD93 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.008246157731829 0.9468422434493456 0.6587114738285964 0.6198216015396206 0.1120119983652299 0.0007261054236978 0.0 0.0019893899204244 0.2436053593179052 0.0 377 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +836888 C1QB LRP1 C1QB-LRP1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0082459643112941 0.4601010570874773 0.7346293219749174 0.8293805866303694 0.0026949121497638 0.0416128058995347 0.0 0.0 0.0 0.0 324 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +837000 MMRN2 CD93 MMRN2-CD93 Macrophages Macrophages Macrophages -> Macrophages 0.0082446139315941 0.893316592628645 0.944024288971064 1.0 0.0007691101630988 0.0484215930647349 0.0 0.0007119609438567 0.0159298523488136 0.0 2458 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +837171 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes B Cells Pericytes -> B Cells 0.0082424543056422 0.9184503888425788 0.7754072541855492 0.6198216015396206 0.1169448695751571 0.0006074333625108 0.0 0.0 0.0 0.0 1063 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +837304 VWF ITGA9 VWF-ITGA9 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0082409405846504 0.7848266128497919 0.9404022517663844 0.7827641335561659 0.0004024409845247 0.1347191569099048 0.0 0.0002336994624912 0.0101293460736911 0.0 389 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +837382 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0082398993863078 0.7487535481622718 0.9546923450729716 0.6198216015396206 0.0015847932820241 0.0445745465878424 0.0 0.0012626262626262 0.0467615767629316 0.0 144 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +837750 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0082353503985334 0.9184503888425788 0.896164124004365 0.9429656149619918 0.0004696576149175 0.0855781119790033 0.0 0.0003107520198881 0.0156587767176956 0.0 3218 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +838129 DLL1 NOTCH3 DLL1-NOTCH3 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0082306804421853 0.6249837837987587 0.6580560501976399 0.7917001487310438 0.00263399584678 0.0362497659817488 0.0 0.0 0.0 0.0 42 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +838232 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0082293215589056 0.8667347161816407 0.8581827408615759 1.0 0.0106228227237899 0.003930762149527 0.0 0.0001021659174499 0.0273911377484336 0.0 19576 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +838277 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0082288473151644 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.016822895653248 0.0045642085393754 0.0 0.0 0.0 0.0 81 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +838289 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0082287277357888 0.8840293712888387 0.7779918296243433 0.6198216015396206 0.0061698665784747 0.0118035014556376 0.0 0.0002126528442317 0.021520052025845 0.0 1881 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +838429 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0082272101489285 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0021291294377375 0.0491709261488903 0.0 0.0010526315789473 0.0475026047398752 0.0 475 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +838438 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0082270940741446 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0149256517769723 0.0064230792457803 0.0 0.0003695491500369 0.0497042505870199 0.0 246 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +839376 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0082156718594363 0.4593282471594782 0.6614977577544194 0.2461374514707439 0.0181222899145132 0.0226890201466244 0.0 0.0 0.0 0.0 186 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +839555 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.00821331924096 0.6160088550075702 0.6632137581773894 0.8824495942126559 0.0106340017102282 0.0080072638027924 0.0 8.758101243650377e-05 0.0211552685250388 0.0 4671 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +839729 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0082111767724755 0.6213271600240247 0.62431395375366 1.0 0.0083518627398662 0.009460730808256 0.0 0.0003407296601013 0.0423036424677984 0.0 4011 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +839932 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.008209031368944 0.633566764858408 0.6572093097629401 0.8824495942126559 0.0799339500711946 0.0010419094417808 0.0 4.1597337770382697e-05 0.0032094885649111 0.0 12020 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +840016 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0082079235307233 0.6342079770588467 0.7754072541855492 0.909150863993142 0.0028649117803088 0.0238720285974944 0.0 0.0003377807802736 0.0823387311445797 0.0 5921 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +840082 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0082072222213905 0.8771078809726828 0.7746834992804791 0.6198216015396206 0.0080232294691882 0.0090444648829713 0.0 0.0 0.0 0.0 1687 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +840547 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0082018891854123 0.6342079770588467 0.6580560501976399 0.9161861017439124 0.002196330917593 0.0362497659817488 0.0 0.0 0.0 0.0 460 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +840583 C1QB LRP1 C1QB-LRP1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0082015591556123 0.7753420160918723 0.8604147465201248 0.8567148457705164 0.0012213774841743 0.0436001007095475 0.0 0.003030303030303 0.071043282709067 0.0 165 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +840595 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0082014412692646 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0051428381563772 0.0326412663903893 0.0 0.0 0.0 0.0 148 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +840637 VWF SELP VWF-SELP Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0082008576676559 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0025256125075084 0.04130664769978 0.0 1.784280488892854e-05 0.0060561064839859 0.0 5095 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +840755 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0081994490226989 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.1740454925211078 0.0009242223287825 0.0 0.0009708737864077 0.185146396374316 0.0 103 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +840793 MMRN2 CD93 MMRN2-CD93 T Lymphocytes 11q13 Invasive Tumor Cells T Lymphocytes -> 11q13 Invasive Tumor Cells 0.0081990559969953 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0031934983073077 0.0289462771086338 0.0 0.0 0.0 0.0 1165 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +840799 A2M LRP1 A2M-LRP1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0081989710603579 0.4648000335061383 0.7769451595923457 0.7204611100467462 0.2100317344087863 0.0005558995075445 0.0 0.0008169934640522 0.1545139112533868 0.0 51 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +840866 CCN1 CAV1 CCN1-CAV1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0081981531350924 0.8619922139338987 0.7283139964676212 0.7204611100467462 0.0054092055025683 0.0124087765732037 0.0 0.0011247443762781 0.0554494630213945 0.0 326 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +841014 CD48 CD2 CD48-CD2 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.008196519323889 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0164675938709007 0.0071918009517169 0.0 0.0001850481125092 0.0452281181819408 0.0 2702 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +841078 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0081958113631861 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0561415215593491 0.0016667952436519 0.0 0.0002436647173489 0.0308272336126025 0.0 570 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +841856 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0081866153979763 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.0085570823799139 0.0090444648829713 0.0 0.0007974481658692 0.0905669067106845 0.0 209 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +842018 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0081848066851507 0.4629984640915818 0.9078204025796472 0.2461374514707439 0.0201301851612071 0.0144359394371152 0.0 0.0010382059800664 0.0908500617638509 0.0 1806 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +842260 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0081818317743132 0.7475533330314548 0.4642836810638544 0.7204611100467462 0.0029751676683741 0.040323117011325 0.0 0.0 0.0 0.0 85 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +842377 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0081804172610383 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0034559943126159 0.0284069116891947 0.0 7.440476190476191e-05 0.0061632723870352 0.0 3360 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +842405 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0081801074446999 0.9067635403815892 0.7841656220878274 0.7827641335561659 0.0411127335336962 0.001309307002134 0.0 0.0006979695431472 0.0834808435275229 0.0 394 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +842414 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0081800200317039 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0131302879503246 0.0064028969591119 0.0 0.0001304023845007 0.0135944919785128 0.0 4880 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +842447 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0081796583510501 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0587727051993296 0.0028784826949613 0.0 0.0005364806866952 0.045630029580579 0.0 233 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +842567 VWF LRP1 VWF-LRP1 Macrophages Macrophages Macrophages -> Macrophages 0.0081781813387705 0.9011206516381156 0.8604147465201248 1.0 0.0008850282134344 0.0436001007095475 0.0 0.0003652267179525 0.006966985644879 0.0 2458 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +842744 C3 LRP1 C3-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0081760952036662 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0334108479684367 0.0028784826949613 0.0 0.0 0.0 0.0 97 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +842766 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.008175841508594 0.6342079770588467 0.7746834992804791 0.909150863993142 0.0073929685753755 0.0090444648829713 0.0 0.0001445755262549 0.0164195727815172 0.0 5764 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +842793 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0081755533660092 0.662063103571249 0.2491073778594529 0.2461374514707439 0.0967042147306326 0.0076066460958003 0.0 0.0024193548387096 1.0 0.0 155 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +842849 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0081750522364781 0.6213271600240247 0.62431395375366 1.0 0.0093830613230477 0.0082011408892332 0.0 0.0007731958762886 0.1296733355647204 0.0 1552 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +842921 VWF SELP VWF-SELP Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0081740911724761 0.6332974881236617 0.7760344326192508 0.909150863993142 0.0019871862905238 0.0335947364052305 0.0 0.0004913174985797 0.0262830834330396 0.0 5921 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +842944 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0081737870118496 0.6332974881236617 0.8604147465201248 0.6198216015396206 0.0020251995753771 0.0436001007095475 0.0 0.0004306220095693 0.0082144520418928 0.0 475 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +843033 CD48 CD2 CD48-CD2 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0081728219625159 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0467114894617178 0.0024832440877005 0.0 0.0022123893805309 0.5655864071872995 0.0 452 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +843145 MMRN2 CD93 MMRN2-CD93 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0081711599072476 0.9468422434493456 0.8817184225858201 0.9429656149619918 0.1120119983652299 0.0003375370073613 0.0 0.0002528658125421 0.1875402276185141 0.0 2966 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +843149 THBS2 CD36 THBS2-CD36 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.00817109643303 0.8858959974474152 0.6176321640000088 0.6198216015396206 0.0030563796158022 0.02871400543887 0.0 0.0001198006517155 0.0579733533282936 0.0 1739 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +843351 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0081687175622135 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0186793449598515 0.0046263543438723 0.0 2.872572676088705e-05 0.0156592592637324 0.0 11604 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +843652 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.008165012335733 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.002676946692949 0.0326412663903893 0.0 6.59862748548302e-05 0.0224774035149807 0.0 5683 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +843853 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0081626953470564 0.4619393085577573 0.6331674633943454 0.2461374514707439 0.0835287751665837 0.0049190726392343 0.0 0.0010653409090909 0.2154222341571681 0.0 176 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +844000 VWF ITGA9 VWF-ITGA9 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0081604522188082 0.9275752708651288 0.2531744428854943 0.2461374514707439 0.1263644540569636 0.0040430820937484 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +844134 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0081589419459925 0.7205550478301406 0.4630027772793905 1.0 0.0151307911035231 0.0058437228618857 0.0 0.000346585573096 0.0701374787383447 0.0 22361 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +844204 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0081580734073148 0.8667347161816407 0.4603649459881741 0.6198216015396206 0.0106228227237899 0.0112209532878862 0.0 0.0 0.0 0.0 800 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +844259 C3 LRP1 C3-LRP1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0081574656876116 0.6319926036888139 0.6207977546603366 0.8693461273411047 0.0042375227960614 0.0203874717835032 0.0 0.0001388888888888 0.0177654769485461 0.0 360 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +844285 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0081571900257171 0.4636527906642655 0.8331580262014722 0.7204611100467462 0.0693389464442948 0.001526625481682 0.0 0.000770178681454 0.3621881000373989 0.0 1082 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +844287 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0081571261860095 0.7205550478301406 0.7154802332407408 0.8293805866303694 0.0117842887908422 0.0058465532256424 0.0 0.0003533568904593 0.0743700567870698 0.0 9905 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +844393 CD48 CD2 CD48-CD2 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0081558603522378 0.7719609236370527 0.7763428264267787 0.8567148457705164 0.0112468593062777 0.0050968401714881 0.0 0.0 0.0 0.0 276 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +844509 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0081545364615188 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0084812136822336 0.0090444648829713 0.0 0.0 0.0 0.0 193 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +844942 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0081493825046429 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0137371823984124 0.0112209532878862 0.0 0.0 0.0 0.0 157 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +845255 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0081459876594639 0.662063103571249 0.6331674633943454 0.9161861017439124 0.0236359933700329 0.0032187363284526 0.0 0.0010723039215686 0.2112225283986556 0.0 408 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +845262 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0081459351899627 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0003521782369754 0.2898144908728011 0.0 0.0004013646397752 0.0093216291896738 0.0 453 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +845277 VWF SELP VWF-SELP Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0081457430567878 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0025256125075084 0.0335947364052305 0.0 0.0002079347916493 0.0111234944681372 0.0 1093 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +845486 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0081433680753281 0.7840818683779507 0.7754072541855492 0.6198216015396206 0.0032417203409647 0.0238720285974944 0.0 0.0 0.0 0.0 388 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +845567 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.008142323650383 0.7741139100414175 0.8755243548400705 0.6198216015396206 0.1671376945154473 0.0004150165744076 0.0 0.0069444444444444 1.0 0.0 18 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +845757 HSPG2 LRP1 HSPG2-LRP1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0081400842096978 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0012941512528773 0.0587195251380622 0.0 0.0002265439843858 0.0159726904388514 0.0 797 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +845839 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0081391167894015 0.9219165193585238 0.62431395375366 0.6198216015396206 0.0086134406931133 0.009460730808256 0.0 0.0002630590003757 0.0326603615796842 0.0 887 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +845850 VWF SELP VWF-SELP Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.008138989212757 0.6332974881236617 0.7760344326192508 0.8693461273411047 0.0020251995753771 0.0335947364052305 0.0 0.0 0.0 0.0 575 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +845851 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0081389769318153 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0083518627398662 0.0124087765732037 0.0 0.001255230125523 0.0618823600246373 0.0 239 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +845990 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0081374156304885 0.4629984640915818 0.6207977546603366 0.2461374514707439 0.0201301851612071 0.0203874717835032 0.0 0.0008776792313377 0.0274179172968576 0.0 902 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +845993 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0081373589778977 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0003521782369754 0.2879885658616873 0.0 0.0 0.0 0.0 77 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +846027 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0081369901698257 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0338862305197021 0.0027830389352876 0.0 0.0 0.0 0.0 129 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +846171 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0081351213649895 0.7487535481622718 0.7757991160529997 0.8567148457705164 0.0131092554497256 0.0044430418127202 0.0 0.0016589250165892 0.0620124649092817 0.0 137 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +846281 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0081335939749064 0.8533682807143209 0.7461459456652184 0.6198216015396206 0.0706049302656684 0.0010390313650636 0.0 0.0005537098560354 0.0526838544211817 0.0 129 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +846606 CCN1 CAV1 CCN1-CAV1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0081296558030715 0.8749036366850302 0.7283139964676212 0.7204611100467462 0.0004337320404416 0.1449812920932466 0.0 0.0002561639449247 0.0209971687834376 0.0 1041 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +846688 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0081285264903811 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.000895875398841 0.0826982152707935 0.0 0.0008424599831508 0.031269272896654 0.0 1187 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +846697 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Pericytes 11q13 Invasive Tumor Cells -> Pericytes 0.0081284660049776 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0106340017102282 0.0091569531245039 0.0 8.770391159445713e-05 0.0229561606579042 0.0 5701 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +846739 CD34 SELP CD34-SELP CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0081279715985136 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0298399317533219 0.0053213839468185 0.0 0.0002969121140142 0.1163010667026941 0.0 1684 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +846825 CXCL12 CXCR4 CXCL12-CXCR4 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0081268447153262 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0052742025956585 0.0310998965832685 0.0 0.0017127477367262 0.3232179988210349 0.0 4087 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +846828 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0081267999887609 0.8818165186409654 0.9078204025796472 0.9429656149619918 0.0026436039558049 0.0144359394371152 0.0 0.0002716277162771 0.0237692666718936 0.0 2710 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +846967 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0081251568026508 0.6301823358791634 0.6347970925105053 0.8824495942126559 0.00146889578236 0.0554888093272979 0.0 2.8676301904106445e-05 0.0046930836598986 0.0 5812 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +846969 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0081251199173896 0.6303642896310324 0.6331674633943454 0.909150863993142 0.0161193721503025 0.0049190726392343 0.0 0.000795165394402 0.0971304333506678 0.0 1572 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +847046 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0081239848317082 0.6160088550075702 0.4596166826058663 0.2461374514707439 0.0548063857429699 0.0075270071967493 0.0 0.0002932551319648 0.1294528403701048 0.0 155 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +847100 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0081231697197958 0.6160088550075702 0.8622452992050237 1.0 0.0021291294377375 0.0254056950469408 0.0 0.0001021659174499 0.0160533877476589 0.0 19576 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +847222 CCN1 CAV1 CCN1-CAV1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0081216861166715 0.9219165193585238 0.252518874138558 0.2461374514707439 0.2646489893253856 0.0018925243453249 0.0 0.0088888888888888 0.492390331244405 0.0 15 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +847651 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0081164113099931 0.4625081978296446 0.885766439573873 0.7204611100467462 0.0704104148800194 0.0013756087909864 0.0 0.0 0.0 0.0 1538 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +847782 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.008114900112699 0.6593525851613742 0.8998347793593909 0.6198216015396206 0.0120646829101097 0.0064362797035136 0.0 0.0 0.0 0.0 119 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +847839 HSPG2 LRP1 HSPG2-LRP1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0081143441825534 0.7789175740361626 0.6207977546603366 0.909150863993142 0.0012941512528773 0.0501711964086628 0.0 0.0005828132845563 0.0098886563686293 0.0 1549 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +848071 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.008111361741288 0.2490567623945399 0.6580560501976399 0.2461374514707439 0.011649387573427 0.0606066271159369 0.0 0.0013404825737265 0.0379548994076488 0.0 373 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +848178 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0081101114409088 0.6249837837987587 0.8923034233058523 0.6198216015396206 0.0435116250366991 0.00189193058407 0.0 0.0003390487261455 0.1279382464179431 0.0 3441 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +848259 COL4A2 CD93 COL4A2-CD93 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0081089762704183 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0267593032157803 0.0026174949623928 0.0 0.0020325203252032 0.2757431789864014 0.0 246 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +848280 COL4A2 CD93 COL4A2-CD93 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0081087022238143 0.8355319038299565 0.7779918296243433 0.6198216015396206 0.001123788079051 0.0627790816848129 0.0 0.0012345679012345 0.0270758391933545 0.0 162 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +848415 C1QB LRP1 C1QB-LRP1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0081072762480635 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0026949121497638 0.0350138403862125 0.0 0.0 0.0 0.0 452 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +848473 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0081065197747081 0.9184503888425788 0.6571792026963191 0.6198216015396206 0.0004696576149175 0.1615138601457002 0.0 0.0001759633996128 0.0168190698455914 0.0 5683 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +848580 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0081052860890391 0.8840293712888387 0.4630027772793905 0.7204611100467462 0.0061698665784747 0.0155837683010033 0.0 0.0001459720828391 0.0403533951766408 0.0 10961 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +848821 C3 LRP1 C3-LRP1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0081019292861543 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.005043231651446 0.0203874717835032 0.0 0.0004290909090909 0.0548856335108538 0.0 6875 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +848826 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0081018739984013 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0151307911035231 0.0053794918117879 0.0 0.000290909090909 0.0351162582270969 0.0 6875 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +849051 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0080993055954759 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0172764782878141 0.0058465532256424 0.0 0.0001299646496153 0.0273533037933312 0.0 6412 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +849095 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0080987500222727 0.6342079770588467 0.4641352222874551 0.2461374514707439 0.0085570823799139 0.0455121851821151 0.0 0.0 0.0 0.0 351 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +849153 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0080981682382475 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0265972645862203 0.0267255153180908 0.0 0.0009692132269099 0.1534511451108885 0.0 877 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +849199 A2M LRP1 A2M-LRP1 B Cells Macrophages B Cells -> Macrophages 0.0080974572299467 0.7741139100414175 0.8604147465201248 0.6198216015396206 0.0015661096645571 0.0436001007095475 0.0 0.000508607198748 0.0145703511596317 0.0 1065 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +849415 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.008094471358567 0.4604235282221027 0.8347945881127203 0.7204611100467462 0.0839650520556947 0.0012097093680331 0.0 0.0056390977443609 0.311375919623496 0.0 38 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +849480 CD48 CD2 CD48-CD2 Macrophages Pericytes Macrophages -> Pericytes 0.0080937143454975 0.7719609236370527 0.7763428264267787 0.8875000050982297 0.0212837736082081 0.0024832440877005 0.0 0.0002021018593371 0.0516663411577727 0.0 2474 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +849521 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0080932229313373 0.4636527906642655 0.8998347793593909 0.7204611100467462 0.014525360548861 0.0064362797035136 0.0 0.0005640157924421 0.2043559068165042 0.0 591 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +849596 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.008092400561398 0.7463064942968751 0.7779918296243433 0.6198216015396206 0.0012430446376512 0.0627790816848129 0.0 0.0004201680672268 0.0084368066795771 0.0 170 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +849735 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0080906008256416 0.718867305289982 0.9015117569158254 0.7204611100467462 0.0024319941937022 0.0246995741084876 0.0 0.0013353115727002 0.067966105026779 0.0 337 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +849834 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0080896126672672 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0016575843792215 0.0373075519081129 0.0 0.0039682539682539 0.0748765421655604 0.0 246 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +849872 C1QB LRP1 C1QB-LRP1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0080890928802916 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0026949121497638 0.0587195251380622 0.0 0.0004222972972972 0.0359904421777399 0.0 148 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +849919 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.008088659641013 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0515877972474039 0.0016667952436519 0.0 0.0 0.0 0.0 570 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +850007 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0080875330069905 0.633566764858408 0.6572093097629401 0.8824495942126559 0.0018436902762588 0.04130664769978 0.0 8.271298593879239e-05 0.0315665556444754 0.0 12090 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +850241 HSPG2 LRP1 HSPG2-LRP1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0080850247011672 0.8349903778527206 0.6207977546603366 0.6198216015396206 0.0014804857410621 0.0587195251380622 0.0 0.001068376068376 0.0753268300577788 0.0 78 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +850242 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0080850187440738 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0052742025956585 0.0178869147172998 0.0 0.0011145249713838 0.1905296480085754 0.0 1509 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +850335 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0080839799523527 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0101610580570933 0.0083242517891534 0.0 0.0006114476124817 0.0715309521224803 0.0 11604 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +850592 A2M LRP1 A2M-LRP1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0080809304335362 0.8392912392980421 0.6207977546603366 0.6198216015396206 0.0005164482812395 0.166956519448744 0.0 0.0081018518518518 0.0790009749404051 0.0 144 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +850829 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0080781389185967 0.7487535481622718 0.7754239189773715 0.8875000050982297 0.0338862305197021 0.0015914585039484 0.0 0.0007150851884094 0.3471667836188263 0.0 1462 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +850997 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0080762065175087 0.8630183004227985 0.8891607331132086 0.8693461273411047 0.0006856224272495 0.0606680526002441 0.0 0.0008722620662919 0.0288465599392767 0.0 737 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +851204 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.008073695200717 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.1928969878996252 0.0003375370073613 0.0 0.0007213706041478 0.5604313270835005 0.0 1109 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +851589 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0080693113602662 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.1661175896787547 0.0009249287638231 0.0 0.0010548523206751 0.6072971675468075 0.0 79 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +851621 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0080689111297881 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.002196330917593 0.0689186266365139 0.0 0.00050390526581 0.0473890596918556 0.0 1323 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +851692 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0080679202361891 0.4636527906642655 0.4630488285702799 0.2461374514707439 0.014525360548861 0.0359289752254096 0.0 0.0004940197607904 0.1246157296134521 0.0 12820 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +851744 VWF SELP VWF-SELP Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0080672783318995 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0020251995753771 0.04130664769978 0.0 6.317936622070055e-05 0.0214439922313292 0.0 30217 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +851790 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0080666858889217 0.6160088550075702 0.9008184599638702 0.7917001487310438 0.0001971810371238 0.3180524283074206 0.0 0.0007065473386716 0.0098186156779226 0.0 193 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +851864 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0080657321523413 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0308750930304183 0.0049190726392343 0.0 0.0009517766497461 0.1924584426987898 0.0 394 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +851918 A2M LRP1 A2M-LRP1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0080649955377871 0.4648000335061383 0.8604147465201248 0.7204611100467462 0.0021905373114471 0.0436001007095475 0.0 0.0043273986152324 0.1239693767348261 0.0 337 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +851938 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.008064788595347 0.6301823358791634 0.944024288971064 0.6198216015396206 0.0015409900107563 0.0484215930647349 0.0 0.0004592774035517 0.0102761552987623 0.0 1633 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +852040 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0080634527869577 0.662063103571249 0.6331674633943454 0.9161861017439124 0.0967042147306326 0.0007400708115376 0.0 0.0004076086956521 0.0795613923243657 0.0 460 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +852339 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0080598587484863 0.4604235282221027 0.6587114738285964 0.2461374514707439 0.0126864732057784 0.0289462771086338 0.0 0.0003840245775729 0.0567564848953139 0.0 186 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +852637 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.008056463564372 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0110717612136884 0.0069492509109592 0.0 0.0002814126917123 0.0481571757484015 0.0 2369 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +852742 VWF ITGA9 VWF-ITGA9 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0080550258024456 0.8525936146535493 0.7292496872084557 0.7204611100467462 0.0002103933337194 0.2898144908728011 0.0 0.0 0.0 0.0 66 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +852950 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0080525204893549 0.6589792304505506 0.8755243548400705 0.6198216015396206 0.1836996873148393 0.0004150165744076 0.0 0.0022435897435897 0.3118503118503122 0.0 130 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +852960 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0080524069436979 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0093830613230477 0.009460730808256 0.0 0.0014354066985645 0.178214399515119 0.0 209 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +853104 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0080506774348814 0.8349903778527206 0.7346293219749174 0.7204611100467462 0.0014804857410621 0.0416128058995347 0.0 0.0048400673400673 0.1598229670369818 0.0 66 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +853388 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0080471284832724 0.9275752708651288 0.9404022517663844 0.9429656149619918 0.000245041593909 0.1347191569099048 0.0 0.0001130007345047 0.0048978441549606 0.0 3218 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +853441 VWF ITGA9 VWF-ITGA9 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0080465453016977 0.8525936146535493 0.7292496872084557 0.7204611100467462 0.0002103933337194 0.2879885658616873 0.0 0.0001746572351759 0.0064363979100606 0.0 1041 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +853522 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Plasma Cells B Cells -> Plasma Cells 0.0080455404022864 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0052742025956585 0.0292791515533623 0.0 0.005050505050505 0.1192544171312743 0.0 297 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +853541 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells B Cells Mast Cells -> B Cells 0.0080453556496458 0.7487535481622718 0.9460955677032749 0.6198216015396206 0.0016417770622885 0.0376195773145198 0.0 0.0109577922077922 0.3986863203782703 0.0 112 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +853696 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.008043498855764 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0015409900107563 0.0554888093272979 0.0 8.449514152936205e-05 0.0138282394075189 0.0 3945 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +853709 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0080432853813131 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.011891719340537 0.0064028969591119 0.0 5.635245901639345e-05 0.0106762005609521 0.0 4880 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +853731 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0080430290371566 0.4619393085577573 0.7167436199046466 1.0 0.0308750930304183 0.0026482500471321 0.0 0.0001257770224945 0.0469338233231974 0.0 22361 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +853770 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0080424974919082 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0052742025956585 0.0292373734098458 0.0 0.001008064516129 0.1539371961976895 0.0 496 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +853819 VWF SELP VWF-SELP Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0080418414580009 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0019871862905238 0.04130664769978 0.0 3.456619426201175e-05 0.0117322671239195 0.0 3945 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +853985 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0080398916958518 0.6342079770588467 0.896164124004365 0.6198216015396206 0.000895875398841 0.0855781119790033 0.0 0.0 0.0 0.0 345 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +854022 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0080394165285205 0.9845127857250529 0.2491545808994955 0.2461374514707439 1.0 0.0004471667362236 0.0 0.0101010101010101 1.0 0.0 33 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +854160 CD34 SELP CD34-SELP Pericytes B Cells Pericytes -> B Cells 0.0080374841087821 0.9303167350027568 0.7760344326192508 0.6198216015396206 0.1314667522621683 0.0004582650848664 0.0 0.0014111006585136 1.0 0.0 1063 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +854307 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0080357235046933 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0213929720256037 0.0032187363284526 0.0 0.000390625 0.0769453496309388 0.0 2400 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +854387 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0080348155649591 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0021291294377375 0.0390724515618796 0.0 5.866655434779336e-05 0.0331477257999042 0.0 30217 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +854447 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0080341035425476 0.6249837837987587 0.8923034233058523 0.6198216015396206 0.0411214967239829 0.00189193058407 0.0 0.0002449179524859 0.0924184960478938 0.0 1361 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +854593 MMP2 PECAM1 MMP2-PECAM1 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0080323794325787 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0216588811659259 0.0026482500471321 0.0 0.0004122766834631 0.3765337585139459 0.0 2183 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +854842 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0080293269466662 0.8718210606749883 0.4630488285702799 0.7204611100467462 0.0017670878089588 0.0521374123931907 0.0 6.0821701182982085e-05 0.0108206816588143 0.0 10961 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +855035 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0080270264615927 0.743507317541692 0.4630488285702799 0.7204611100467462 0.0020684923107111 0.0521374123931907 0.0 0.0008960573476702 0.1594159834170218 0.0 1302 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +855243 C1QB LRP1 C1QB-LRP1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0080244165472632 0.7452691992612583 0.8604147465201248 0.7827641335561659 0.0012199377895337 0.0436001007095475 0.0 0.0 0.0 0.0 162 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +855447 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0080219563802457 0.8949858186325867 0.4641352222874551 0.7204611100467462 0.001895566065636 0.046975263367762 0.0 0.000102522042239 0.0169611796154887 0.0 9754 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +855478 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0080216483338883 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0117842887908422 0.0079745943515326 0.0 0.0001436286338044 0.0172100035875895 0.0 11604 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +855611 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0080199784767205 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0020491452254277 0.0455125113141721 0.0 5.208333333333333e-05 0.0118430879005516 0.0 800 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +855622 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0080198398770212 0.4648000335061383 0.6207977546603366 0.2461374514707439 0.0357762282281787 0.0104714078116759 0.0 0.0018459915611814 0.2533785311930238 0.0 316 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +855639 C1QB LRP1 C1QB-LRP1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0080197344947106 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.0037630364713574 0.0144359394371152 0.0 0.000248508946322 0.0232228437790073 0.0 1509 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +855736 CD48 CD2 CD48-CD2 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0080184732259711 0.7719609236370527 0.8581827408615759 0.6198216015396206 0.0164675938709007 0.003930762149527 0.0 0.0 0.0 0.0 1971 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +856166 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0080128444716284 0.8516956437178343 0.6571792026963191 0.6198216015396206 0.000472352586488 0.1615138601457002 0.0 0.0 0.0 0.0 78 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +856315 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Pericytes Mast Cells -> Pericytes 0.0080110803657023 0.8516956437178343 0.896164124004365 0.8567148457705164 0.000472352586488 0.0855781119790033 0.0 0.0 0.0 0.0 244 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +856477 CD34 SELP CD34-SELP CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0080090557918887 0.9303167350027568 0.6572093097629401 0.6198216015396206 0.0016860250240652 0.04130664769978 0.0 8.798169980644026e-05 0.0335773058016635 0.0 5683 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +856603 CD48 CD2 CD48-CD2 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0080074980433042 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0164675938709007 0.0062523288579129 0.0 0.0 0.0 0.0 474 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +856671 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0080067776101738 0.8630183004227985 0.8445107771175474 1.0 0.0016575843792215 0.0218093597373452 0.0 0.0010922344504992 0.0591940110512419 0.0 4011 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +856872 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0080042140138358 0.4601010570874773 0.9078204025796472 0.2461374514707439 0.0177188549930425 0.0144359394371152 0.0 6.921373200442968e-05 0.0064679348952606 0.0 1806 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +856935 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0080035434651379 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0101610580570933 0.0073658308476012 0.0 0.0008987858091443 0.1636459804799975 0.0 10040 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +857031 CD34 SELP CD34-SELP CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0080021218538063 0.633566764858408 0.6572093097629401 1.0 0.0298399317533219 0.002113171886167 0.0 0.0006607513686992 0.191380480779489 0.0 5297 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +857060 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0080017895549629 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0039530346951707 0.0203874717835032 0.0 0.0005791912384161 0.0327998399209208 0.0 1187 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +857150 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0080006426074753 0.6301823358791634 0.944024288971064 0.6198216015396206 0.00146889578236 0.0484215930647349 0.0 0.0005510653930933 0.0123298762695656 0.0 1361 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +857349 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.007998127737242 0.7487535481622718 0.9460955677032749 0.6198216015396206 0.0015847932820241 0.0376195773145198 0.0 0.0031565656565656 0.1148479112200778 0.0 144 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +857412 COL4A1 CD93 COL4A1-CD93 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0079973226775795 0.4604235282221027 0.944024288971064 0.7204611100467462 0.0017253404164066 0.0484215930647349 0.0 0.0012717253073336 0.0430931892301524 0.0 337 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +857558 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0079957117598438 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.0037268694422441 0.0203874717835032 0.0 0.0008133133133133 0.0482246279218767 0.0 1332 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +857562 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0079956662581292 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0031934983073077 0.0292771742399634 0.0 7.660017771241228e-05 0.0087752547509017 0.0 10879 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +857593 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0079953085837034 0.6301823358791634 0.6587114738285964 0.8824495942126559 0.0024635726452692 0.0289462771086338 0.0 0.0003718700933807 0.0769002229540171 0.0 12101 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +857805 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0079928422437963 0.9219165193585238 0.943345641464811 1.0 0.0086134406931133 0.0034806998160403 0.0 0.0001078211827154 0.039916231928996 0.0 4019 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +858100 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0079893232345866 0.2486570577556728 0.9404022517663844 0.2461374514707439 0.0033537993821664 0.1347191569099048 0.0 0.0009426057813154 0.0408558071474571 0.0 1736 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +858260 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0079873233973376 0.6303642896310324 0.6331674633943454 0.9318789094584046 0.0141923232885854 0.0049190726392343 0.0 0.0005439121756487 0.0664395428893023 0.0 5010 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +858467 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0079847914385936 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0131092554497256 0.0064230792457803 0.0 0.0 0.0 0.0 390 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +858509 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0079842483255632 0.8498991475190484 0.2550748532138862 0.2461374514707439 0.018166235813628 0.0267255153180908 0.0 0.0017816419612314 0.110834720507585 0.0 877 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +858686 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0079819456830329 0.8624864526942296 0.4638256179742202 0.7204611100467462 0.0020100505037262 0.0446401662952339 0.0 0.0 0.0 0.0 66 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +858739 COL4A2 CD93 COL4A2-CD93 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0079814143809136 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.0047240947268779 0.0289462771086338 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +858805 VWF SELP VWF-SELP Pericytes B Cells Pericytes -> B Cells 0.0079807066474367 0.9275752708651288 0.7760344326192508 0.6198216015396206 0.1263644540569636 0.0004582650848664 0.0 0.0015821431625759 0.79571714716915 0.0 1063 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +858858 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.007980014755489 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0548063857429699 0.0015914585039484 0.0 0.0009456985967053 0.4591273115603282 0.0 1490 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +858896 A2M LRP1 A2M-LRP1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0079795427605332 0.4648000335061383 0.7346293219749174 0.8293805866303694 0.0021905373114471 0.0416128058995347 0.0 0.0021862139917695 0.1296859448062277 0.0 324 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +858986 CD48 CD2 CD48-CD2 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0079784314085611 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0212837736082081 0.0038288178384739 0.0 0.0 0.0 0.0 129 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +859016 C1QB LRP1 C1QB-LRP1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0079781797574515 0.7753420160918723 0.9078204025796472 0.8567148457705164 0.0012213774841743 0.0350138403862125 0.0 0.0007684426229508 0.0270150423237977 0.0 244 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +859264 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0079751409893525 0.4619393085577573 0.2491073778594529 0.2461374514707439 0.1194227711616854 0.0076066460958003 0.0 0.0005106919332406 0.2127581585761336 0.0 5752 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +859359 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0079739125467962 0.7160288858520609 0.4641352222874551 0.2461374514707439 0.0069047442087267 0.0455121851821151 0.0 0.0006240249609984 0.0456873903168188 0.0 12820 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +859514 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0079718433021888 0.6303682835571691 0.663300745568453 0.6198216015396206 9.902323108165852e-05 1.0 0.0 0.0054945054945054 0.0941885345704389 0.0 78 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +859599 CD48 CD2 CD48-CD2 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0079708383956886 0.4593282471594782 0.4603649459881741 0.2461374514707439 0.0467114894617178 0.0105486447632276 0.0 0.0055350553505535 1.0 0.0 271 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +859602 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0079708006096652 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0526353932596327 0.0021449819680126 0.0 0.0095238095238095 0.3456375838926175 0.0 5 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +859664 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.007970141993317 0.8624864526942296 0.6580560501976399 0.6198216015396206 0.0020100505037262 0.0362497659817488 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +859810 MMP2 PECAM1 MMP2-PECAM1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0079684432801828 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0024819960935566 0.0326412663903893 0.0 9.410288582183188e-05 0.0381281742563267 0.0 797 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +860001 A2M LRP1 A2M-LRP1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0079661955878323 0.4648000335061383 0.8755243548400705 0.7204611100467462 0.2100317344087863 0.0004150165744076 0.0 0.006578947368421 0.9569377990430624 0.0 38 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +860052 CD34 SELP CD34-SELP Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0079654640298757 0.8963354148873306 0.4623922682986163 0.7204611100467462 0.0038492365148421 0.0222228052993653 0.0 0.0005126102111954 0.1369763559487228 0.0 9754 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +860202 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.007963739073338 0.8730912658940219 0.7757991160529997 0.7204611100467462 0.0057086106530109 0.0091569531245039 0.0 0.0010056315366049 0.2632201768115694 0.0 452 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +860369 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0079616972014725 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0117842887908422 0.0076236123034427 0.0 0.0002988643156007 0.0266345271776288 0.0 1673 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +860669 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0079579308026182 0.6593525851613742 0.7472387841445823 0.6198216015396206 0.0120646829101097 0.0068935067166085 0.0 0.0 0.0 0.0 21 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +860674 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0079578686133334 0.4601010570874773 0.6207977546603366 0.2461374514707439 0.0177188549930425 0.0203874717835032 0.0 0.0006236141906873 0.035315530122475 0.0 902 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +860915 CD34 SELP CD34-SELP CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0079552302029955 0.9303167350027568 0.7760344326192508 0.6198216015396206 0.0016860250240652 0.0335947364052305 0.0 0.0 0.0 0.0 1881 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +861016 CD48 CD2 CD48-CD2 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0079538589809805 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0351142257737683 0.0038288178384739 0.0 0.0021459227467811 0.4013508883559301 0.0 233 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +861018 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0079538479177823 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0101610580570933 0.0070956399217802 0.0 0.0006939551171182 0.0870938260795046 0.0 15611 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +861079 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0079531912809986 0.8949858186325867 0.4638256179742202 0.7204611100467462 0.001895566065636 0.0446401662952339 0.0 0.0004662004662004 0.0421903847483099 0.0 715 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +861193 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0079515473848366 0.7840818683779507 0.6571792026963191 0.6198216015396206 0.0032417203409647 0.0244129856070659 0.0 0.0 0.0 0.0 30 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +861199 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0079515057959166 0.9470274865242416 0.7746834992804791 0.6198216015396206 0.0061455194924501 0.0090444648829713 0.0 0.0001878992859827 0.0264374443534043 0.0 887 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +861217 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0079512869911882 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.2545335314555431 0.0003375370073613 0.0 0.0004551365409622 0.3535946352526995 0.0 1538 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +861227 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0079511711008834 0.9184503888425788 0.4638256179742202 0.2461374514707439 0.0004696576149175 0.5131068416842878 0.0 0.0007824726134585 0.0177755960631313 0.0 1491 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +861228 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0079511640216646 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0020251995753771 0.0350138403862125 0.0 0.0006995915897746 0.0285774771074996 0.0 1803 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +861301 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0079503610518584 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0016171311116606 0.0501711964086628 0.0 0.0006801663492557 0.0137887622713763 0.0 2339 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +861544 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.007947591865676 0.9219165193585238 0.62431395375366 0.6198216015396206 0.0086134406931133 0.0082011408892332 0.0 0.0002564102564102 0.0430027813667619 0.0 390 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +861611 VWF LRP1 VWF-LRP1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0079468188313266 0.6332974881236617 0.6207977546603366 0.8693461273411047 0.0036144684673052 0.0203874717835032 0.0 0.0001850252867891 0.0086633960458165 0.0 737 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +861650 THBS2 CD36 THBS2-CD36 B Cells Macrophages B Cells -> Macrophages 0.0079463611637175 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0008527942416386 0.088850508457521 0.0 0.0005477308294209 0.0106973501440508 0.0 1065 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +861786 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0079448808152329 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0016417770622885 0.049767778498468 0.0 0.0 0.0 0.0 78 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +861846 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0079441406349197 0.8911088195487638 0.9078204025796472 1.0 0.0048525806497539 0.0064028969591119 0.0 0.0003296840009952 0.0624599631994537 0.0 4019 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +861854 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0079440387935523 0.7800321422220979 0.6331674633943454 0.909150863993142 0.0113788029360913 0.0049190726392343 0.0 0.0001987913486005 0.0401975330912442 0.0 1572 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +862082 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0079414301132508 0.8949858186325867 0.6580560501976399 0.6198216015396206 0.001895566065636 0.0362497659817488 0.0 0.0 0.0 0.0 129 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +862165 VEGFC FLT1 VEGFC-FLT1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0079403994907973 0.8963332422588541 0.6593689120110077 0.6198216015396206 0.0026007495851186 0.026308073552735 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +862463 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0079366729304476 0.4636527906642655 0.7472387841445823 0.7204611100467462 0.014525360548861 0.0068935067166085 0.0 0.0 0.0 0.0 51 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +862479 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0079364287774272 0.4619393085577573 0.6331674633943454 0.2461374514707439 0.0835287751665837 0.0041555861088636 0.0 0.0015080428954423 0.1915203990400454 0.0 373 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +862543 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0079357128417142 0.7800321422220979 0.930308383061206 0.6198216015396206 0.1357656553382984 0.0004089864655001 0.0 5.63570784490532e-05 0.0724362562042784 0.0 1109 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +863219 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0079277375193171 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.0084325366891025 0.0155837683010033 0.0 0.0 0.0 0.0 77 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +863296 MMP2 PECAM1 MMP2-PECAM1 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0079268454217696 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0216588811659259 0.0032187363284526 0.0 0.0008547910510764 0.2486900231693327 0.0 2369 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +863350 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0079262246887002 0.831981591331937 0.7467524951532132 0.7827641335561659 0.0048935684578858 0.0104195741475089 0.0 0.0144927536231884 1.0 0.0 23 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +863358 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0079261585066951 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0151307911035231 0.0057802287131517 0.0 0.0003393939393939 0.0583891659094889 0.0 6875 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +863362 VWF LRP1 VWF-LRP1 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0079260932669137 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0019871862905238 0.0350138403862125 0.0 0.0010427182402635 0.0425937891138791 0.0 1711 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +863677 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0079221401571028 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0016171311116606 0.0487643047611538 0.0 0.0004275331338178 0.0167348662416548 0.0 2339 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +863755 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0079212435976413 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0265972645862203 0.0032275631628407 0.0 0.0022151898734177 0.2053834337034769 0.0 79 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +863776 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0079210128091371 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0072827533047186 0.0104714078116759 0.0 0.0001673360107095 0.0139871102536858 0.0 83 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +863799 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0079208042230598 0.7160288858520609 0.4638256179742202 0.8767341187813953 0.0012306151710811 0.0689186266365139 0.0 0.0004081632653061 0.038385138350403 0.0 2450 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +864108 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0079170231797559 0.6160088550075702 0.6632137581773894 0.8824495942126559 0.0106340017102282 0.0064230792457803 0.0 0.0001788200917689 0.0240512490703576 0.0 11947 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +864136 CD48 CD2 CD48-CD2 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.00791674197555 0.4593282471594782 0.4603649459881741 1.0 0.0161888123016941 0.0071918009517169 0.0 0.0002906846742095 0.0710470407968719 0.0 22361 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +864253 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.007915111163529 0.9097736029185508 0.8445107771175474 0.8693461273411047 0.0430965463818576 0.0008542071298387 0.0 0.0014991181657848 0.276878820568141 0.0 270 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +864302 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0079143548328771 0.6319926036888139 0.6207977546603366 0.9161861017439124 0.0004094805141934 0.166956519448744 0.0 0.0003063725490196 0.0043089883322555 0.0 408 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +864396 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0079132370188347 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0028649117803088 0.046975263367762 0.0 0.0002997601918465 0.0495921300867738 0.0 3336 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +864489 VWF SELP VWF-SELP CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.007912156982687 0.6332974881236617 0.6572093097629401 0.8824495942126559 0.0016171311116606 0.04130664769978 0.0 0.0001173121441531 0.0398174413316092 0.0 5812 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +864679 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0079097690240281 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0168149984327668 0.0058437228618857 0.0 0.0011129097531363 0.2712588637484701 0.0 1412 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +864919 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0079066876220782 0.6659645551150886 0.8581827408615759 0.7917001487310438 0.0137371823984124 0.003930762149527 0.0 0.0 0.0 0.0 1305 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +864927 COL4A1 CD93 COL4A1-CD93 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0079066076185529 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0126216524880575 0.0042738820064046 0.0 0.0002678571428571 0.0193590065715781 0.0 2400 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +864982 COL4A2 CD93 COL4A2-CD93 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0079060663130699 0.7482742921073442 0.7779918296243433 0.6198216015396206 0.005733874009046 0.0118035014556376 0.0 0.0005154639175257 0.052163940542029 0.0 388 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +865159 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0079037561362784 0.6342079770588467 0.4641352222874551 0.2461374514707439 0.0073929685753755 0.0455121851821151 0.0 0.0 0.0 0.0 383 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +865307 CD34 SELP CD34-SELP T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0079019221817386 0.633566764858408 0.7760344326192508 0.8693461273411047 0.015517736049123 0.0036702914086929 0.0 0.0006784260515603 0.2774636471377034 0.0 737 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +865425 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0079005173390842 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0015572459193676 0.0501711964086628 0.0 0.0009243149195302 0.0187382964523834 0.0 209 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +865486 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.007899627957994 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0020251995753771 0.0416128058995347 0.0 0.000203808200533 0.0084503814465344 0.0 6412 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +865605 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0078982427110222 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0015847932820241 0.049767778498468 0.0 0.0001181660627067 0.0403827170190818 0.0 1154 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +865643 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0078976921724252 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0172764782878141 0.0042738820064046 0.0 0.0006695232994108 0.0854669571145141 0.0 1867 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +865672 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0078974445311515 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0172764782878141 0.0044340558155446 0.0 0.001953125 0.254698148275625 0.0 1280 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +865897 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0078946229139808 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0033537993821664 0.1886404570313 0.0 0.0002015722636565 0.0052717661497417 0.0 902 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +866042 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0078927643749548 0.6213271600240247 0.8818704453527788 0.6198216015396206 0.013905026986541 0.0051192928876727 0.0 0.0001646808098421 0.0310249949791893 0.0 3441 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +866139 THBS2 CD36 THBS2-CD36 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.0078914961845509 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0087456089304998 0.0056518532344078 0.0 0.0001717819514429 0.1423368566461367 0.0 2183 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +866340 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0078891939891944 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0018436902762588 0.0335947364052305 0.0 0.0 0.0 0.0 69 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +866477 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0078872983767199 0.7296454584598743 0.8341464445360613 0.7204611100467462 0.293296467876477 0.0001871866311057 0.0 0.0 0.0 0.0 38 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +866569 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0078862060989726 0.9097736029185508 0.4614667734221426 0.6198216015396206 0.0430965463818576 0.0021449819680126 0.0 0.0066305003013863 0.2406337609378982 0.0 79 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +866596 COL4A1 CD93 COL4A1-CD93 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0078858516458051 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.0017253404164066 0.0627790816848129 0.0 0.0031628887717448 0.0635095410565952 0.0 271 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +866676 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0078849567736326 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0361307801045652 0.0023576674662702 0.0 0.0001999999999999 0.095900642478736 0.0 6875 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +866947 CD34 SELP CD34-SELP CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0078815548410129 0.633566764858408 0.7478729882108823 0.6198216015396206 0.0298399317533219 0.0027351735586246 0.0 0.0 0.0 0.0 143 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +867086 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0078799141041973 0.6593525851613742 0.6593689120110077 1.0 0.0120646829101097 0.0045642085393754 0.0 9.028530155290718e-05 0.0103477282722237 0.0 1846 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +867100 C1QB LRP1 C1QB-LRP1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0078797386133222 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0026949121497638 0.0501711964086628 0.0 0.0053044280442804 0.1263410812645302 0.0 271 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +867114 A2M LRP1 A2M-LRP1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0078795758900264 0.919551140852988 0.6207977546603366 0.6198216015396206 0.037376181609614 0.0018097844702233 0.0 0.0 0.0 0.0 129 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +867132 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Pericytes Mast Cells -> Pericytes 0.0078793617119438 0.7487535481622718 0.7754239189773715 0.8567148457705164 0.0016417770622885 0.0293031867940321 0.0 0.0009314456035767 0.1165708385690112 0.0 244 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +867334 A2M LRP1 A2M-LRP1 B Cells Pericytes B Cells -> Pericytes 0.0078769131738302 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.0015661096645571 0.0350138403862125 0.0 0.0002408477842003 0.0140633022117707 0.0 1211 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +867401 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0078762381963512 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0526353932596327 0.0008542071298387 0.0 0.0056689342403628 1.0 0.0 42 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +867430 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.00787577572297 0.8349903778527206 0.6207977546603366 0.6198216015396206 0.0014804857410621 0.0501711964086628 0.0 0.0013717421124828 0.02327449757266 0.0 162 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +867502 HSPG2 LRP1 HSPG2-LRP1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0078749757057288 0.9253089325030373 0.9078204025796472 0.8875000050982297 0.0022161183602947 0.0144359394371152 0.0 0.0003683791318199 0.0322356714572364 0.0 2790 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +867532 VWF LRP1 VWF-LRP1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0078747197012131 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0019871862905238 0.0416128058995347 0.0 0.0003058202420808 0.0126800476766646 0.0 1412 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +867681 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0078729285109123 0.6332974881236617 0.8604147465201248 0.6198216015396206 0.0016171311116606 0.0436001007095475 0.0 0.0005510653930933 0.0105120038988219 0.0 1361 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +867711 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0078724733714094 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0015572459193676 0.0487643047611538 0.0 0.0013049151805132 0.0510781019650683 0.0 209 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +867715 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0078724259261868 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.0070489045197697 0.0104714078116759 0.0 0.0006038647342995 0.0828857307008235 0.0 69 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +867774 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0078717135346554 0.4648000335061383 0.9078204025796472 0.2461374514707439 0.0357762282281787 0.0064028969591119 0.0 0.0008128612716763 0.1144364333148162 0.0 1384 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +867807 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0078711379620628 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0265972645862203 0.0028784826949613 0.0 0.00037109375 0.0960128536945379 0.0 1280 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +868181 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0078663572414941 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0069047442087267 0.009971631136135 0.0 0.0 0.0 0.0 1362 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +868192 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0078662693438047 0.633566764858408 0.8347297932672282 0.6198216015396206 0.0799339500711946 0.0009042150166242 0.0 0.0 0.0 0.0 42 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +868340 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.007864627966274 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0014431743145616 0.0518891167572028 0.0 0.0004784688995215 0.0174692639362715 0.0 209 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +868377 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0078641827148722 0.8718210606749883 0.777821334064334 0.6198216015396206 0.0017670878089588 0.0318483483218543 0.0 0.0 0.0 0.0 1881 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +868491 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0078628159808398 0.7753420160918723 0.8604147465201248 0.8875000050982297 0.0009153913192522 0.0436001007095475 0.0 0.000877808988764 0.020579602610597 0.0 1424 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +868495 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Mast Cells B Cells -> Mast Cells 0.0078627855892556 0.7797302331085993 0.8381155706134242 0.6198216015396206 0.0200499113739789 0.0029095741067474 0.0 0.0017182130584192 0.0542713685772361 0.0 97 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +868513 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0078625527851547 0.6332974881236617 0.6572093097629401 0.8824495942126559 0.0015572459193676 0.04130664769978 0.0 9.766285280705576e-05 0.0331481871718708 0.0 12101 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +868570 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0078619295453262 0.743507317541692 0.777821334064334 0.6198216015396206 0.0020684923107111 0.0318483483218543 0.0 0.0030068728522336 0.3805241782040667 0.0 388 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +868612 CD34 SELP CD34-SELP CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0078612196590164 0.633566764858408 0.941479368642921 0.6198216015396206 0.0298399317533219 0.0021392900294222 0.0 0.0 0.0 0.0 1361 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +868749 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0078594807907285 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0161757332769496 0.0042655619249233 0.0 0.0003615328994938 0.0915539631493157 0.0 922 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +868770 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0078592909373343 0.8516956437178343 0.4638256179742202 0.2461374514707439 0.000472352586488 0.5131068416842878 0.0 0.0 0.0 0.0 41 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +868982 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0078567943356696 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0083898580598364 0.0073658308476012 0.0 0.0015219901333053 0.2771155987462046 0.0 1361 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +869125 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0078551731236538 0.8771078809726828 0.8818326005152037 0.8875000050982297 0.0080232294691882 0.0042655619249233 0.0 0.0 0.0 0.0 1462 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +869153 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0078547353953315 0.7475533330314548 0.7763400818577846 0.6198216015396206 0.0029751676683741 0.0219439768073448 0.0 0.0 0.0 0.0 162 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +869310 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0078528622972871 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0036991419150414 0.166956519448744 0.0 0.0003401360544217 0.0047838564341775 0.0 147 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +869358 HSPG2 LRP1 HSPG2-LRP1 B Cells Macrophages B Cells -> Macrophages 0.0078521817428194 0.7789175740361626 0.8604147465201248 0.6198216015396206 0.0012941512528773 0.0436001007095475 0.0 0.0009911319770474 0.0227769188726239 0.0 1065 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +869409 CCN1 CAV1 CCN1-CAV1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0078515641278626 0.8749036366850302 0.7283139964676212 0.7204611100467462 0.0004337320404416 0.1176565474247238 0.0 0.0 0.0 0.0 66 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +869614 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0078491697401238 0.6160088550075702 0.7447682696221608 0.6198216015396206 0.0255753403203798 0.0032154705418133 0.0 0.0017627801561319 0.1496321664334527 0.0 361 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +869676 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.007848208180819 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0035190936623492 0.0203874717835032 0.0 0.0006704980842911 0.037970584451819 0.0 1305 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +869691 CD34 SELP CD34-SELP T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0078480124804022 0.633566764858408 0.6572093097629401 0.7917001487310438 0.015517736049123 0.0045674276780054 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +869784 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0078468804796428 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0110717612136884 0.0059327142047454 0.0 0.0008841732979664 0.2369114378502329 0.0 377 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +869900 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.007845403874004 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0028649117803088 0.0446401662952339 0.0 0.0001180358829084 0.0106820556285558 0.0 1412 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +869904 A2M LRP1 A2M-LRP1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0078453356151775 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.0021905373114471 0.0350138403862125 0.0 0.00101401179941 0.0592089913915925 0.0 452 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +869911 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0078452235241222 0.7475533330314548 0.4642836810638544 0.2461374514707439 0.0029751676683741 0.0917308979735958 0.0 0.0013661202185792 0.0751716836430695 0.0 122 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +869951 C3 LRP1 C3-LRP1 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.007844836123209 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0064915662046245 0.0104714078116759 0.0 0.0006311207834602 0.0621049882022601 0.0 4595 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +870028 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0078438891604708 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0048313935743179 0.0118035014556376 0.0 0.0 0.0 0.0 83 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +870153 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0078421533627303 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0308750930304183 0.0041555861088636 0.0 9.484066767830046e-05 0.0120446988436919 0.0 659 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +870433 CD48 CD2 CD48-CD2 Endothelial Cells Pericytes Endothelial Cells -> Pericytes 0.0078385919929499 0.7719609236370527 0.7763428264267787 0.946515890536252 0.0164675938709007 0.0024832440877005 0.0 0.0002636435539151 0.0673991711174952 0.0 11379 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +870460 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0078382609161423 0.7800321422220979 0.8537710813834968 0.6198216015396206 0.1357656553382984 0.0004138063814779 0.0 0.0069444444444444 0.6067961165048547 0.0 18 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +870554 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.007837133080262 0.6659645551150886 0.6614977577544194 1.0 0.0137371823984124 0.0038288178384739 0.0 0.0012886597938144 0.2410174149147724 0.0 1552 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +870962 VWF ITGA9 VWF-ITGA9 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0078325675074094 0.7848266128497919 0.6252253442669611 0.6198216015396206 0.0004024409845247 0.1886404570313 0.0 0.0005611672278338 0.0146763366267501 0.0 162 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +871003 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0078319219325428 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0028649117803088 0.0244129856070659 0.0 0.0 0.0 0.0 246 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +871155 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Mast Cells B Cells -> Mast Cells 0.0078299518945859 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0052742025956585 0.0147571931436988 0.0 0.0056232427366447 0.1126113631891992 0.0 97 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +871280 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0078286553079353 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0255753403203798 0.0027830389352876 0.0 0.0 0.0 0.0 81 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +871350 A2M LRP1 A2M-LRP1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0078277397397664 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.0021905373114471 0.0587195251380622 0.0 0.0016891891891891 0.2171969484383231 0.0 148 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +871516 A2M LRP1 A2M-LRP1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0078258583725774 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.0015661096645571 0.0416128058995347 0.0 0.0015120967741935 0.0896973944627514 0.0 496 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +871694 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0078235724709832 0.2542249848376565 0.62431395375366 0.2461374514707439 0.1711385759005754 0.0034299077593249 0.0 0.0089743589743589 0.9283819628647214 0.0 26 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +871695 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0078235702509754 0.6332974881236617 0.8604147465201248 0.6198216015396206 0.0015572459193676 0.0436001007095475 0.0 0.0 0.0 0.0 103 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +871900 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0078209791975271 0.4636527906642655 0.6593689120110077 0.2461374514707439 0.0666348171285698 0.0045642085393754 0.0 0.0 0.0 0.0 26 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +871927 CCN1 CAV1 CCN1-CAV1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0078206194659568 0.8619922139338987 0.62431395375366 0.6198216015396206 0.0054092055025683 0.0126805820762719 0.0 0.0001771066368381 0.0360811530398897 0.0 3576 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +872092 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.00781852256235 0.7487535481622718 0.7757991160529997 0.8567148457705164 0.0016417770622885 0.0279580382843415 0.0 0.0003293807641633 0.0461886009443923 0.0 276 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +872166 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0078176908653147 0.2490567623945399 0.4638256179742202 0.2461374514707439 0.011649387573427 0.0689186266365139 0.0 0.00085400013664 0.0803132378206664 0.0 4879 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +872196 VWF ITGA9 VWF-ITGA9 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0078174207088987 0.7848266128497919 0.8794572885381431 0.7827641335561659 0.0004024409845247 0.104965956217838 0.0 0.0 0.0 0.0 162 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +872229 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0078170802634283 0.6342079770588467 0.7746834992804791 0.8693461273411047 0.0002327631000826 0.2295016807597237 0.0 0.0004629629629629 0.0230141825286804 0.0 360 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +872235 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.007816977646011 0.8533682807143209 0.6587114738285964 0.7917001487310438 0.0706049302656684 0.0007261054236978 0.0 0.0006141751627564 0.0821234152645101 0.0 1163 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +872509 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0078133592679779 0.6342079770588467 0.6571792026963191 0.9161861017439124 0.0085570823799139 0.0069630688870869 0.0 0.0021834061135371 0.2757003033707368 0.0 458 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +872729 MMP2 PECAM1 MMP2-PECAM1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0078106746961454 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0024819960935566 0.0326667674102811 0.0 0.0047138047138047 0.0941958210511852 0.0 297 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +872788 VEGFC FLT1 VEGFC-FLT1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0078100795175315 0.4636527906642655 0.4630488285702799 0.8767341187813953 0.0023125636768155 0.0521374123931907 0.0 0.0012244897959183 0.2178468214204853 0.0 2450 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +872791 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0078100510050031 0.6605327397359113 0.8381155706134242 0.6198216015396206 0.0227314494836465 0.0029095741067474 0.0 0.0 0.0 0.0 130 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +872811 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0078098125489836 0.8498991475190484 0.7346293219749174 0.6198216015396206 0.018166235813628 0.0032275631628407 0.0 0.0 0.0 0.0 79 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +872978 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0078080099820052 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0083898580598364 0.0070956399217802 0.0 0.0016866250632484 0.2116774216319495 0.0 2541 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +873163 C1QB LRP1 C1QB-LRP1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0078058618426139 0.7452691992612583 0.9078204025796472 0.7827641335561659 0.0012199377895337 0.0350138403862125 0.0 0.0008033419023136 0.0282419465595829 0.0 389 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +873217 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0078050891866737 0.6342079770588467 0.7754072541855492 0.8693461273411047 0.0053032910137447 0.009971631136135 0.0 0.0 0.0 0.0 1044 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +873304 VWF ITGA9 VWF-ITGA9 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0078040074084316 0.7158082793127664 0.9404022517663844 0.7204611100467462 0.0003457348439318 0.1347191569099048 0.0 0.0002011263073209 0.0087175124395262 0.0 452 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +873336 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0078035361270492 0.8667347161816407 0.7763428264267787 0.6198216015396206 0.0106228227237899 0.0050968401714881 0.0 0.0 0.0 0.0 1692 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +873512 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0078015420530439 0.8023917560710954 0.6632137581773894 0.6198216015396206 0.0085367158000785 0.0080072638027924 0.0 0.0004656035385868 0.1124669333110902 0.0 1562 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +873742 VWF LRP1 VWF-LRP1 Macrophages Pericytes Macrophages -> Pericytes 0.0077987594667095 0.9011206516381156 0.9078204025796472 0.8875000050982297 0.0008850282134344 0.0350138403862125 0.0 0.0009232380392445 0.037713166248586 0.0 2474 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +873841 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0077974473345535 0.6582846571368821 0.6587114738285964 1.0 0.0198024073017111 0.0026174949623928 0.0 0.0009020618556701 0.1223788026326245 0.0 1552 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +874020 CD34 SELP CD34-SELP Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0077954245093703 0.7871981482311898 0.4623922682986163 0.7204611100467462 0.0038506427265089 0.0222228052993653 0.0 0.0 0.0 0.0 1302 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +874037 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.007795222917595 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0137371823984124 0.0050968401714881 0.0 0.0 0.0 0.0 370 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +874051 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0077949629613453 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0033973231723341 0.0203874717835032 0.0 0.0015562108022091 0.0486146390936138 0.0 1187 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +874166 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0077936003197436 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.000895875398841 0.1370986982961073 0.0 0.0 0.0 0.0 453 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +874180 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.007793458818922 0.6332974881236617 0.7831795333113832 0.6198216015396206 0.0131302879503246 0.0055509879377996 0.0 0.0001202501202501 0.0089678594078477 0.0 756 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +874199 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Pericytes CAFs, DCIS Associated -> Pericytes 0.0077931901635443 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0351142257737683 0.0024832440877005 0.0 3.2028697713150986e-05 0.008187978222044 0.0 15611 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +874227 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0077929396528638 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0071496754272206 0.0112932915661816 0.0 0.000390167772142 0.0146187829882565 0.0 233 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +874232 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0077928129185942 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0024319941937022 0.0326412663903893 0.0 0.0 0.0 0.0 148 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +874511 COL4A1 CD93 COL4A1-CD93 Mast Cells Pericytes Mast Cells -> Pericytes 0.0077892659779217 0.7766289238087107 0.8817184225858201 0.8567148457705164 0.0002970267018348 0.1281708518900828 0.0 0.0005854800936768 0.0137956173794971 0.0 244 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +874652 COL4A2 CD93 COL4A2-CD93 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0077874650084292 0.7482742921073442 0.4630027772793905 0.7204611100467462 0.005733874009046 0.0155837683010033 0.0 0.0003840245775729 0.1061620498586693 0.0 1302 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +874689 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0077870472124723 0.7487535481622718 0.8628183098412396 0.6198216015396206 0.0016417770622885 0.0339152418223636 0.0 0.0045454545454545 0.347283218247909 0.0 30 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +874697 THBS2 CD36 THBS2-CD36 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0077869762581108 0.7809827257946271 0.8587566561291643 0.7827641335561659 0.0004779710276932 0.088850508457521 0.0 0.0012860082304526 0.0251161329440347 0.0 162 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +874772 VEGFC FLT1 VEGFC-FLT1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0077861010327489 0.7745997874735252 0.777821334064334 0.9318789094584046 0.0012459853895406 0.0318483483218543 0.0 0.0002674690738883 0.0338486043600923 0.0 4985 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +874774 COL4A2 CD93 COL4A2-CD93 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0077860845128504 0.7783550150988336 0.7779918296243433 0.9318789094584046 0.0033449520260795 0.0118035014556376 0.0 8.02407221664995e-05 0.0081202041846769 0.0 4985 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +874839 A2M LRP1 A2M-LRP1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0077852229492327 0.7460047258226694 0.8604147465201248 0.7827641335561659 0.0010163752993685 0.0436001007095475 0.0 0.0023148148148148 0.0663137777137085 0.0 162 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +874851 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0077850748865274 0.7160288858520609 0.4641352222874551 0.8767341187813953 0.0186793449598515 0.0040904475843412 0.0 0.0012229922543823 0.1286172818525738 0.0 2453 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +874905 CD34 SELP CD34-SELP T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0077844175763591 0.633566764858408 0.7760344326192508 0.909150863993142 0.015517736049123 0.0032078747392388 0.0 0.0003469812630117 0.0794360470173605 0.0 5764 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +874909 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.007784366018475 0.7160288858520609 0.836885603004631 0.7204611100467462 0.0186793449598515 0.0027591088867233 0.0 0.0018484288354898 0.0272400038914291 0.0 1082 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +875127 COL4A1 CD93 COL4A1-CD93 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0077817434156665 0.9102252263107924 0.7779918296243433 0.6198216015396206 0.0042860632265532 0.0118035014556376 0.0 0.0001997443272611 0.0189526433493152 0.0 3576 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +875299 VWF ITGA9 VWF-ITGA9 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0077797872471597 0.6332974881236617 0.6252253442669611 0.909150863993142 0.0019871862905238 0.0309945332907452 0.0 0.0004299028112573 0.0268168562972007 0.0 5921 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +875482 THBS2 CD36 THBS2-CD36 Myoepithelial Cells 11q13 Invasive Tumor Cells Myoepithelial Cells -> 11q13 Invasive Tumor Cells 0.0077775286006259 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0027791828709671 0.02871400543887 0.0 0.0001063133791298 0.0514466574560445 0.0 5095 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +875552 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0077767979402985 0.2534163760166434 0.8923034233058523 0.2461374514707439 0.2100740470724093 0.00189193058407 0.0 0.0 0.0 0.0 222 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +875762 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0077742610983368 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0208904415011529 0.0058437228618857 0.0 0.0001936858415649 0.0391956205024117 0.0 5163 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +875789 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0077739631986917 0.7835752212271604 0.7746834992804791 0.6198216015396206 0.0064863313435223 0.0090444648829713 0.0 0.0 0.0 0.0 170 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +875815 CD48 CD2 CD48-CD2 Pericytes Endothelial Cells Pericytes -> Endothelial Cells 0.0077737566640239 0.7719609236370527 0.7763428264267787 0.946515890536252 0.0076331962782219 0.0050968401714881 0.0 0.0001806032147372 0.0459624146129838 0.0 11074 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +875828 COL4A1 CD93 COL4A1-CD93 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0077735784486618 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0016831757123532 0.0289462771086338 0.0 0.0001792435920415 0.0264911071280511 0.0 797 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +875937 A2M LRP1 A2M-LRP1 Macrophages B Cells Macrophages -> B Cells 0.0077722264004847 0.919551140852988 0.6207977546603366 0.6198216015396206 0.037376181609614 0.0016667952436519 0.0 0.0013578522656734 0.272667135909527 0.0 1074 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +875947 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0077721125083752 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0683610513379333 0.0018097844702233 0.0 0.0030279094260136 0.2693819165206223 0.0 422 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +876028 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0077712781798097 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0117842887908422 0.0053794918117879 0.0 0.0003242542153047 0.0391414194732962 0.0 1542 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +876031 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.007771259923695 0.6332974881236617 0.6572093097629401 0.8824495942126559 0.0131302879503246 0.0045674276780054 0.0 7.989833887548793e-05 0.0134475321928203 0.0 11947 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +876371 CD34 SELP CD34-SELP Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0077673406979754 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.0018206581062216 0.04130664769978 0.0 0.0 0.0 0.0 148 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +876513 CD48 CD2 CD48-CD2 Pericytes CAFs, DCIS Associated Pericytes -> CAFs, DCIS Associated 0.0077655856027623 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0076331962782219 0.0112209532878862 0.0 3.85297064036372e-05 0.0075703973666484 0.0 12977 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +876622 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Mast Cells Pericytes -> Mast Cells 0.0077642637983422 0.9356727248601746 0.8341464445360613 0.8567148457705164 0.1750253929104546 0.0001871866311057 0.0 0.0011111111111111 0.1410579345088163 0.0 225 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +876663 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0077636030905583 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0027791828709671 0.0284069116891947 0.0 0.0006424375917767 0.0532159201699959 0.0 1362 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +876690 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0077633211833891 0.9470274865242416 0.8818326005152037 1.0 0.0061455194924501 0.0042655619249233 0.0 6.220452848967405e-05 0.0157525666876715 0.0 4019 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +876826 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0077614959842866 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.0198024073017111 0.0058437228618857 0.0 0.0014005602240896 0.425014076273401 0.0 714 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +876924 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0077604117678193 0.8498991475190484 0.6207977546603366 0.7917001487310438 0.018166235813628 0.0028784826949613 0.0 0.001025390625 0.0872139588819427 0.0 1280 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +877230 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0077568314786963 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0012306151710811 0.0606066271159369 0.0 0.0 0.0 0.0 3 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +877358 C3 LRP1 C3-LRP1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0077551377136961 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0042375227960614 0.0144359394371152 0.0 0.0002319416832339 0.0396097702828663 0.0 1509 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +877433 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0077541725935927 0.6342079770588467 0.6580560501976399 0.9592803095773328 0.000895875398841 0.0606066271159369 0.0 0.0006775067750677 0.0191831673157899 0.0 1476 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +877534 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.007752806595212 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0025256125075084 0.0309945332907452 0.0 0.0001663478333194 0.0103765916962309 0.0 1093 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +877661 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0077512508596183 0.6332974881236617 0.6252253442669611 0.8824495942126559 0.0131302879503246 0.0047273851759697 0.0 8.31946755407654e-05 0.0039010990031807 0.0 12020 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +877819 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.007749313988574 0.7800321422220979 0.6331674633943454 0.8693461273411047 0.0213929720256037 0.0023576674662702 0.0 8.480325644504748e-05 0.0263258514429487 0.0 737 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +878050 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0077463785448574 0.6332974881236617 0.6252253442669611 0.8693461273411047 0.0020251995753771 0.0309945332907452 0.0 0.000790513833992 0.0493113683651322 0.0 575 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +878055 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.007746278693028 0.7487535481622718 0.4596166826058663 0.2461374514707439 0.0338862305197021 0.0075270071967493 0.0 0.00017283097131 0.0762934990774381 0.0 263 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +878106 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0077455789406135 0.4604235282221027 0.7461459456652184 0.7204611100467462 0.0839650520556947 0.0010390313650636 0.0 0.0 0.0 0.0 51 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +878108 MMP2 PECAM1 MMP2-PECAM1 B Cells Macrophages B Cells -> Macrophages 0.0077455756731514 0.6303642896310324 0.9015117569158254 0.6198216015396206 0.0024819960935566 0.0246995741084876 0.0 0.0008450704225352 0.0430132908807972 0.0 1065 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +878112 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0077455482897834 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0208904415011529 0.003263637675389 0.0 4.96031746031746e-05 0.0049986801223295 0.0 3360 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +878286 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0077433914443769 0.4604235282221027 0.4630027772793905 0.2461374514707439 0.0839650520556947 0.0048929293424311 0.0 0.0003287274348116 0.0884582719764729 0.0 12820 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +878457 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0077413356243648 0.7487535481622718 0.8628183098412396 0.6198216015396206 0.0015847932820241 0.0339152418223636 0.0 0.0002805836139169 0.0214372356943153 0.0 162 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +878563 COL4A2 CD93 COL4A2-CD93 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0077399082756907 0.9188764516910942 0.7779918296243433 0.6198216015396206 0.0090193130488293 0.0053794918117879 0.0 0.0 0.0 0.0 594 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +878689 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0077382399541799 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0069047442087267 0.0090444648829713 0.0 0.0001223690651003 0.0138975649798333 0.0 1362 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +878865 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0077359185804262 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0071496754272206 0.0064028969591119 0.0 0.0001950881362646 0.0203380031255262 0.0 11475 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +878985 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0077342669316739 0.7487535481622718 0.7757991160529997 0.8875000050982297 0.0338862305197021 0.0012252690191386 0.0 0.00049745056585 0.3991403530767982 0.0 1462 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +879033 C1QB LRP1 C1QB-LRP1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0077337662764749 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0012213774841743 0.0587195251380622 0.0 0.0 0.0 0.0 78 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +879055 C1QB LRP1 C1QB-LRP1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0077335504024862 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0161519521398178 0.0032275631628407 0.0 0.0003955696202531 0.0157640323582392 0.0 474 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +879221 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0077314592650017 0.6659645551150886 0.6614977577544194 0.8824495942126559 0.1496557267835524 0.0003671083100858 0.0 4.1597337770382697e-05 0.0468260108310599 0.0 12020 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +879358 CD48 CD2 CD48-CD2 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.00772999287394 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0467114894617178 0.0024251058581756 0.0 0.0035087719298245 0.5641804052046689 0.0 285 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +879600 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0077266881321363 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0039530346951707 0.0144359394371152 0.0 0.0 0.0 0.0 262 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +879619 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0077264217196711 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0033537993821664 0.166956519448744 0.0 0.0022418058132343 0.0168914741897926 0.0 147 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +879630 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0077263330095613 0.7753420160918723 0.9078204025796472 0.9429656149619918 0.0009153913192522 0.0350138403862125 0.0 0.000135954008701 0.0047795413599592 0.0 3218 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +879861 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0077234732730655 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0075637985935472 0.0064028969591119 0.0 0.0009640877319836 0.1140821209347486 0.0 922 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +880002 CD48 CD2 CD48-CD2 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0077217795291268 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0161888123016941 0.0050968401714881 0.0 0.0 0.0 0.0 2247 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +880094 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0077206401796837 0.6332974881236617 0.6207977546603366 0.9161861017439124 0.0003521782369754 0.166956519448744 0.0 0.0010026737967914 0.0075549088414792 0.0 408 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +880140 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0077201410510274 0.250044481781731 0.7779918296243433 0.2461374514707439 0.0070431301838115 0.0627790816848129 0.0 0.0020632737276478 0.0451819017808302 0.0 727 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +880172 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.007719848485232 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0161193721503025 0.0041555861088636 0.0 0.0012195121951219 0.2317053792313839 0.0 246 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +880274 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0077186135691457 0.4630253981438691 0.7779918296243433 0.2461374514707439 0.0443339118517084 0.0053794918117879 0.0 0.0005543237250554 0.0598401230798307 0.0 902 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +880311 VWF SELP VWF-SELP CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0077181188942813 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0016171311116606 0.0335947364052305 0.0 0.000197628458498 0.010572156046673 0.0 2300 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +880324 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0077179371967428 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.1740454925211078 0.0003375370073613 0.0 0.0001844262295081 0.143280355420605 0.0 4880 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +880367 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0077174200904064 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.00263399584678 0.0446401662952339 0.0 0.0 0.0 0.0 496 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +880484 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0077161364244171 0.7487535481622718 0.7754239189773715 0.7827641335561659 0.0015847932820241 0.0293031867940321 0.0 0.0009347978499649 0.1169903737206734 0.0 389 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +880553 CD34 SELP CD34-SELP Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0077151395773856 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.0018206581062216 0.0335947364052305 0.0 0.0 0.0 0.0 753 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +880594 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0077147744249498 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.0047694898966413 0.0118035014556376 0.0 0.0001139211665527 0.0108093544843941 0.0 1881 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +880600 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0077147239278646 0.7475533330314548 0.9130058539314824 0.7827641335561659 0.0029751676683741 0.0132636308162813 0.0 0.0 0.0 0.0 162 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +880630 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0077142909462065 0.7451589345683471 0.6331674633943454 0.6198216015396206 0.0040724665904272 0.0176963220730796 0.0 0.0006443298969072 0.1177864036717379 0.0 388 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +880754 CCN1 CAV1 CCN1-CAV1 Macrophages Macrophages Macrophages -> Macrophages 0.0077127432767768 0.8619922139338987 0.8818704453527788 1.0 0.0054092055025683 0.0051192928876727 0.0 0.0003932736642256 0.0740906816631963 0.0 2458 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +880801 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0077123176615802 0.6303642896310324 0.930308383061206 0.6198216015396206 0.141548283585814 0.0004089864655001 0.0 0.0004362416107382 0.7923987092147724 0.0 1490 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +880838 CCN1 CAV1 CCN1-CAV1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0077118244132183 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0083518627398662 0.0082011408892332 0.0 0.0012195121951219 0.2045254235736241 0.0 246 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +880942 C1QB LRP1 C1QB-LRP1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0077104851867625 0.7753420160918723 0.2550748532138862 0.2461374514707439 0.0161519521398178 0.0267255153180908 0.0 0.0003915662650602 0.024359067923026 0.0 2075 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +881714 C1QB LRP1 C1QB-LRP1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0077009112464029 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0012213774841743 0.0416128058995347 0.0 0.002840909090909 0.1125535990834424 0.0 66 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +881847 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0076990262290727 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0003521782369754 0.1886404570313 0.0 0.0003829363559776 0.0100150233089027 0.0 1187 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +881870 CD34 SELP CD34-SELP CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0076987466926657 0.633566764858408 0.4623922682986163 0.2461374514707439 0.0298399317533219 0.0096770075292062 0.0 0.0 0.0 0.0 155 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +881993 MMRN2 CD93 MMRN2-CD93 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0076973765269603 0.893316592628645 0.7779918296243433 0.6198216015396206 0.0007691101630988 0.0627790816848129 0.0 0.0008891523414344 0.0194708017751414 0.0 1687 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +882214 THBS2 CD36 THBS2-CD36 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0076947393189238 0.724503440376099 0.7373999388878224 0.8767341187813953 0.0009736808737186 0.0455125113141721 0.0 0.0003061224489795 0.0696083533746708 0.0 2450 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +882442 CD48 CD2 CD48-CD2 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0076918299308523 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0112468593062777 0.0071918009517169 0.0 0.0 0.0 0.0 66 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +882499 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0076912094533241 0.662063103571249 0.7841656220878274 0.6198216015396206 0.0491302556793708 0.001309307002134 0.0 0.0054347826086956 0.6712457071495477 0.0 23 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +882656 CD48 CD2 CD48-CD2 Macrophages Macrophages Macrophages -> Macrophages 0.0076893242571167 0.7719609236370527 0.7763428264267787 1.0 0.0212837736082081 0.0016204239758814 0.0 0.0 0.0 0.0 2458 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +882767 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0076881222031666 0.7745997874735252 0.4630488285702799 0.2461374514707439 0.0065101973396288 0.0359289752254096 0.0 0.0004432624113475 0.1118122657925851 0.0 752 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +882819 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0076873376088885 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0215813276111062 0.0043013567716651 0.0 0.0 0.0 0.0 79 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +882905 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated T Lymphocytes CAFs, DCIS Associated -> T Lymphocytes 0.0076863059527139 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0071496754272206 0.0104714078116759 0.0 0.0001890022249381 0.0158678797082347 0.0 11604 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +883194 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0076826474755291 0.8284725546778968 0.6331674633943454 0.6198216015396206 0.0012187708721425 0.0518891167572028 0.0 0.0023148148148148 0.1184753437160806 0.0 162 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +883301 C1QB LRP1 C1QB-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.007681434209271 0.7452691992612583 0.6207977546603366 0.6198216015396206 0.0012199377895337 0.0587195251380622 0.0 0.0002166377816291 0.0184630344620641 0.0 1154 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +883578 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0076779730924013 0.7158082793127664 0.2531744428854943 0.2461374514707439 0.0071496754272206 0.0642389143033604 0.0 0.0006321911746112 0.0295889856712319 0.0 5752 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +883579 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.007677969756022 0.6342079770588467 0.7746834992804791 0.8693461273411047 0.0053032910137447 0.0090444648829713 0.0 0.0001596424010217 0.0181307313242653 0.0 1044 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +883639 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0076773709115484 0.7324582304061453 0.252518874138558 0.2461374514707439 0.2376713873232418 0.0018925243453249 0.0 0.003972036860502 0.2200266613639798 0.0 1049 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +883656 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0076772086227668 0.6342079770588467 0.6571792026963191 0.9161861017439124 0.002196330917593 0.0244129856070659 0.0 0.0019011406844106 0.0667663792045163 0.0 526 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +883688 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0076768162253581 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0052560850129547 0.0126805820762719 0.0 0.0 0.0 0.0 69 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +883752 VEGFC FLT1 VEGFC-FLT1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0076759475691639 0.8963332422588541 0.777821334064334 0.6198216015396206 0.0026007495851186 0.0182001711419816 0.0 0.0005611672278338 0.0672123846591325 0.0 594 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +883955 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0076733544691244 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.002196330917593 0.0238720285974944 0.0 0.0 0.0 0.0 2300 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +884132 CD34 SELP CD34-SELP Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0076710794167703 0.2491449441646273 0.8819126042133903 0.2461374514707439 0.0003767662344862 1.0 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +884201 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0076702035384666 0.2451358214448441 0.773263018678637 0.2461374514707439 0.1327555461750915 0.0032875740549697 0.0 0.0026762643041712 0.4318285847672571 0.0 1806 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +884215 C3 LRP1 C3-LRP1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0076700645711698 0.6319926036888139 0.6207977546603366 0.9318789094584046 0.0334108479684367 0.0016667952436519 0.0 0.0005888223552894 0.1081491579193552 0.0 5010 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +884236 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0076697311922871 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0015572459193676 0.0335947364052305 0.0 0.0 0.0 0.0 83 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +884410 VWF LRP1 VWF-LRP1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.007667515204127 0.955713094717548 0.2550748532138862 0.2461374514707439 1.0 0.0003386430177035 0.0 0.0189393939393939 1.0 0.0303030303030303 33 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +884518 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0076662270746819 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0683610513379333 0.0016667952436519 0.0 0.0007402707275803 0.0936553264829576 0.0 394 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +884566 VWF LRP1 VWF-LRP1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0076656884526892 0.7848266128497919 0.6207977546603366 0.6198216015396206 0.0004024409845247 0.166956519448744 0.0 0.0016335227272727 0.0123082056542432 0.0 160 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +884620 COL4A1 CD93 COL4A1-CD93 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0076650071166107 0.9102252263107924 0.4630027772793905 0.7204611100467462 0.0042860632265532 0.0155837683010033 0.0 8.055303318784966e-05 0.0189809257727153 0.0 9754 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +885030 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0076594920393173 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0131302879503246 0.0053724660607752 0.0 0.0 0.0 0.0 103 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +885124 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.0076584997664306 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0016171311116606 0.0350138403862125 0.0 0.0003398805051697 0.0138837108646537 0.0 2541 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +885142 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Mast Cells Pericytes -> Mast Cells 0.007658282966593 0.8721681415062816 0.8381155706134242 0.8567148457705164 0.0110717612136884 0.0029095741067474 0.0 0.0 0.0 0.0 225 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +885226 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0076572208377137 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0024635726452692 0.0292771742399634 0.0 0.0 0.0 0.0 157 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +885279 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0076565575910836 0.7487535481622718 0.7757991160529997 0.7827641335561659 0.0015847932820241 0.0279580382843415 0.0 0.0014822134387351 0.2078487042497655 0.0 460 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +885359 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0076554294467002 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.0839650520556947 0.001079730675535 0.0 0.0001812907904278 0.0279052259820527 0.0 394 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +885407 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0076546127123781 0.6160088550075702 0.9546923450729716 0.7917001487310438 0.0009692519480124 0.0445745465878424 0.0 0.0 0.0 0.0 42 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +885804 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0076491724711629 0.6301823358791634 0.6587114738285964 0.8824495942126559 0.0208904415011529 0.0026174949623928 0.0 0.0 0.0 0.0 11947 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +885841 C1QB LRP1 C1QB-LRP1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0076488014992926 0.7452691992612583 0.7346293219749174 0.7204611100467462 0.0012199377895337 0.0416128058995347 0.0 0.0 0.0 0.0 85 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +886202 CD48 CD2 CD48-CD2 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0076444770028401 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0164675938709007 0.0038288178384739 0.0 0.0 0.0 0.0 407 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +886274 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.007643730293029 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0016575843792215 0.0265498740402422 0.0 0.0013670539986329 0.0347299925274755 0.0 209 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +886323 COL4A1 CD93 COL4A1-CD93 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0076430072107284 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0168149984327668 0.0026174949623928 0.0 0.0008710801393728 0.0849090158500029 0.0 246 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +886382 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0076420630062085 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0052742025956585 0.0215025911544899 0.0 0.001466275659824 0.1761520144024001 0.0 496 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +886513 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0076403197394345 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0548063857429699 0.0012252690191386 0.0 0.0012812690665039 1.0 0.0 1490 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +886671 HSPG2 LRP1 HSPG2-LRP1 B Cells Pericytes B Cells -> Pericytes 0.0076383180616973 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0012941512528773 0.0350138403862125 0.0 0.0005619781631342 0.0240588659593091 0.0 1211 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +886755 C1QB LRP1 C1QB-LRP1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0076370771073766 0.8703788833238396 0.6207977546603366 0.9318789094584046 0.0037630364713574 0.0104714078116759 0.0 0.0003134403209628 0.031348979905234 0.0 4985 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +886894 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0076353792433761 0.250044481781731 0.944024288971064 0.2461374514707439 0.0070431301838115 0.0484215930647349 0.0 0.0 0.0 0.0 222 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +886909 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0076352346944068 0.8721681415062816 0.885766439573873 0.9429656149619918 0.0008193633790489 0.0331922776397286 0.0 6.150061500615006e-05 0.0068272748415903 0.0 2710 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +886953 C3 LRP1 C3-LRP1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0076346109452113 0.7148920381722296 0.9078204025796472 0.7204611100467462 0.0029337538459309 0.0144359394371152 0.0 0.0003264925373134 0.0557566635791466 0.0 536 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +886995 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0076340281226854 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0070532058552773 0.0064028969591119 0.0 0.000103427895981 0.0122387966840569 0.0 1880 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +887094 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0076328921939229 0.9184503888425788 0.4641352222874551 0.7204611100467462 0.0004696576149175 0.1370986982961073 0.0 0.0 0.0 0.0 1884 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +887275 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0076308166673699 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0016417770622885 0.0390724515618796 0.0 0.0017482517482517 0.9877956908241674 0.0 78 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +887280 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0076307355644145 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0016417770622885 0.0484993884807927 0.0 0.0154545454545454 0.2197092398565589 0.0 50 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +887431 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0076289441973152 0.6561647292424944 0.7769451595923457 0.6198216015396206 0.112230917768503 0.0005558995075445 0.0 0.0 0.0 0.0 756 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +887434 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0076288748538605 0.7487535481622718 0.4600037439857229 0.2461374514707439 0.0131092554497256 0.017738069381683 0.0 0.0005182610816413 0.1292077218375614 0.0 1491 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +887460 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0076285803734581 0.4636527906642655 0.777821334064334 0.6198216015396206 0.0693389464442948 0.001271575589586 0.0 0.0003150598613736 0.0771579713560183 0.0 4232 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +887555 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0076276444310676 0.831981591331937 0.4642836810638544 0.7204611100467462 0.0048935684578858 0.0144613249009303 0.0 0.0 0.0 0.0 50 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +887596 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0076270936869506 0.7451589345683471 0.7167436199046466 0.7204611100467462 0.0040724665904272 0.0125623889131764 0.0 0.0002880184331797 0.1337223147956134 0.0 1302 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +887619 C1QB LRP1 C1QB-LRP1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0076268300779039 0.9256868304646206 0.2550748532138862 0.2461374514707439 1.0 0.0003386430177035 0.0 0.006578947368421 0.4086302713305005 0.0 19 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +887754 A2M LRP1 A2M-LRP1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0076251495680997 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.0021905373114471 0.0501711964086628 0.0 0.002460024600246 0.0661204174523485 0.0 271 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +887783 VWF ITGA9 VWF-ITGA9 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0076248750210833 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.00023686843287 0.2898144908728011 0.0 0.000366568914956 0.0085135040784722 0.0 496 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +887829 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0076243528944147 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0149256517769723 0.0044430418127202 0.0 0.0075255869957856 0.2813148242573375 0.0 151 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +887857 CD48 CD2 CD48-CD2 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0076240698824247 0.7719609236370527 0.4603649459881741 0.2461374514707439 0.0212837736082081 0.0105486447632276 0.0 0.0 0.0 0.0 263 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +887888 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0076236421518097 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0213929720256037 0.0026482500471321 0.0 9.780907668231612e-05 0.0364975560191277 0.0 1278 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +887984 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0076224485339641 0.7475533330314548 0.885766439573873 0.7827641335561659 0.0029751676683741 0.0127192475389894 0.0 0.0004284490145672 0.0646206240904205 0.0 389 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +888009 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0076221139879761 0.6301823358791634 0.6347970925105053 0.8693461273411047 0.0172764782878141 0.003263637675389 0.0 0.0 0.0 0.0 1044 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +888383 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0076176090674395 0.6303642896310324 0.8537710813834968 0.6198216015396206 0.141548283585814 0.0004138063814779 0.0 0.0073076923076923 1.0 0.0 130 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +888447 VWF ITGA9 VWF-ITGA9 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0076168473921341 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.00023686843287 0.2879885658616873 0.0 0.0001557043397023 0.0057379534586018 0.0 4087 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +888529 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0076157770128551 0.6242573126045354 0.6176321640000088 0.8693461273411047 0.0020491452254277 0.0284069116891947 0.0 0.0003991060025542 0.0330596986277752 0.0 1044 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +888731 VWF ITGA9 VWF-ITGA9 Mast Cells Pericytes Mast Cells -> Pericytes 0.0076131141478687 0.8525936146535493 0.9404022517663844 0.8567148457705164 0.0002103933337194 0.1347191569099048 0.0 0.0007451564828614 0.0322976690382448 0.0 244 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +888762 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0076127326332815 0.8949858186325867 0.7754072541855492 0.6198216015396206 0.001895566065636 0.0238720285974944 0.0 0.000559284116331 0.1363332290567831 0.0 3576 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +888852 CD48 CD2 CD48-CD2 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0076115610526989 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0467114894617178 0.0016204239758814 0.0 0.0 0.0 0.0 337 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +888959 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0076104858384908 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0015572459193676 0.0350138403862125 0.0 0.0009294794914847 0.0379681220844203 0.0 379 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +889075 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0076088606279964 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0016171311116606 0.0416128058995347 0.0 0.0007422802850356 0.0307767377975302 0.0 1684 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +889087 THBS2 CD36 THBS2-CD36 Pericytes T Lymphocytes Pericytes -> T Lymphocytes 0.0076087098409825 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0087456089304998 0.0063011237754475 0.0 0.0004140319180969 0.0835452706662987 0.0 3321 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +889308 A2M LRP1 A2M-LRP1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0076058697057326 0.7741139100414175 0.2550748532138862 0.2461374514707439 0.0149044683666724 0.0267255153180908 0.0 0.0003263707571801 0.0283901477726222 0.0 383 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +889335 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0076056095553582 0.4619393085577573 0.6331674633943454 0.2461374514707439 0.0835287751665837 0.0032187363284526 0.0 0.0012755102040816 0.2512501212438819 0.0 147 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +889356 A2M LRP1 A2M-LRP1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0076053847254837 0.7741139100414175 0.7769451595923457 0.6198216015396206 0.093381536992618 0.0005558995075445 0.0 0.0023291925465838 0.4405086041323265 0.0 161 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +889542 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0076027327338029 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0117842887908422 0.0057802287131517 0.0 0.0 0.0 0.0 1542 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +889582 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0076022704780834 0.6561647292424944 0.7769451595923457 0.6198216015396206 0.1098969873322313 0.0005558995075445 0.0 0.0026223776223776 0.4959572396175145 0.0 143 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +889593 COL4A2 CD93 COL4A2-CD93 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0076021466579915 0.7783550150988336 0.7779918296243433 0.9318789094584046 0.0316800311254893 0.001079730675535 0.0 0.0001796407185628 0.0303800014287193 0.0 5010 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +889708 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0076005888376602 0.4593282471594782 0.4603649459881741 0.2461374514707439 0.0351142257737683 0.0105486447632276 0.0 0.0002607788595271 0.0484370757876932 0.0 5752 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +889799 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0075994737025007 0.8284725546778968 0.9015117569158254 0.8567148457705164 0.0012187708721425 0.0246995741084876 0.0 0.0018939393939393 0.1824871666071381 0.0 165 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +889833 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.007599042748086 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.0047694898966413 0.0155837683010033 0.0 0.0001629152710258 0.038388159256178 0.0 10961 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +890048 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0075962321050322 0.718867305289982 0.7841656220878274 0.7204611100467462 0.0361307801045652 0.001309307002134 0.0 0.0 0.0 0.0 51 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +890633 HSPG2 LRP1 HSPG2-LRP1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0075888097324902 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0012941512528773 0.0416128058995347 0.0 0.0009240591397849 0.0305131856772919 0.0 496 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +890854 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0075860221850835 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0015847932820241 0.0390724515618796 0.0 0.0002363321254135 0.1335321731096795 0.0 1154 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +890860 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0075859415582193 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0015847932820241 0.0484993884807927 0.0 0.0294840294840294 0.4191591221428788 0.027027027027027 37 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +890878 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.007585772103644 0.7205550478301406 0.4630027772793905 0.8293805866303694 0.0117842887908422 0.0058437228618857 0.0 0.0002019182231196 0.0408615827670775 0.0 9905 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +890891 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0075855953848487 0.255669001367946 0.4596166826058663 0.2461374514707439 0.0061207051981986 0.1076178292491983 0.0 0.0007918910357934 0.0663452084478828 0.0 4879 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +891031 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0075837806742585 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0151307911035231 0.0042738820064046 0.0 0.0016005121638924 0.2043108949203559 0.0 1562 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +891056 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0075835428760429 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0151307911035231 0.0044340558155446 0.0 0.0 0.0 0.0 659 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +891143 A2M LRP1 A2M-LRP1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0075823335807511 0.8937519114898692 0.2550748532138862 0.2461374514707439 1.0 0.0003386430177035 0.0 0.0063131313131313 1.0 0.0 33 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +891413 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0075787345221822 0.2486570577556728 0.8794572885381431 0.2461374514707439 0.0033537993821664 0.104965956217838 0.0 0.0028665028665028 0.0642450837173295 0.0 222 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +891436 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0075783868836763 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0035190936623492 0.0144359394371152 0.0 0.0 0.0 0.0 370 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +891686 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.007575110325531 0.8667347161816407 0.4603649459881741 0.6198216015396206 0.0106228227237899 0.0071918009517169 0.0 7.797878976918278e-05 0.0190590105002501 0.0 6412 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +891859 A2M LRP1 A2M-LRP1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0075731829719612 0.7460047258226694 0.9078204025796472 0.7827641335561659 0.0010163752993685 0.0350138403862125 0.0 0.0008568980291345 0.050034987817714 0.0 389 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +892039 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0075708710980161 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0587727051993296 0.0018097844702233 0.0 0.0009259259259259 0.1021509536940115 0.0 135 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +892081 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0075703972832192 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.002196330917593 0.046975263367762 0.0 0.0 0.0 0.0 1323 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +892156 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0075692330471986 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.0673400749834054 0.00071798405859 0.0 0.0 0.0 0.0 570 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +892291 C3 LRP1 C3-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0075675731449246 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0334108479684367 0.0018097844702233 0.0 0.0009259259259259 0.3269722370845967 0.0 81 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +892336 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0075670404610812 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0137371823984124 0.0071918009517169 0.0 0.0 0.0 0.0 714 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +892379 C3 LRP1 C3-LRP1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.007566438089567 0.7796725988275006 0.8604147465201248 0.7827641335561659 0.000819605673545 0.0436001007095475 0.0 0.0024691358024691 0.0705907426460118 0.0 162 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +892400 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0075661286164593 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0149256517769723 0.0038860320327025 0.0 0.0006524575902566 0.3690816553044793 0.0 209 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +892432 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0075656949702331 0.4619393085577573 0.7167436199046466 0.8767341187813953 0.0051428381563772 0.0125623889131764 0.0 0.0004591836734693 0.2131915761598636 0.0 2450 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +892451 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0075654999975156 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0131302879503246 0.0036702914086929 0.0 7.027511961722486e-05 0.0293117429769414 0.0 30400 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +892463 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0075653628321306 0.8818165186409654 0.2550748532138862 0.2461374514707439 1.0 0.0003386430177035 0.0 0.0075757575757575 1.0 0.0 33 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +892620 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0075631718632018 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0001959417442809 0.287457858136305 0.0 0.0002415458937198 0.0073462607585883 0.0 345 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +892791 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0075611579059179 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0015572459193676 0.0416128058995347 0.0 0.0005252100840336 0.021776481702118 0.0 714 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +892916 EFNB2 PECAM1 EFNB2-PECAM1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0075596217792382 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0014623066995027 0.0326412663903893 0.0 0.0003920953575909 0.1335624050351687 0.0 797 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +893036 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0075582915828744 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0149256517769723 0.0038621268649178 0.0 0.0 0.0 0.0 246 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +893082 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0075577585223052 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0141923232885854 0.0041555861088636 0.0 0.0 0.0 0.0 97 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +893150 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0075568312135921 0.9275752708651288 0.8794572885381431 0.8875000050982297 0.000245041593909 0.104965956217838 0.0 0.0 0.0 0.0 1424 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +893320 VWF LRP1 VWF-LRP1 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.007554880005971 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0036144684673052 0.0144359394371152 0.0 0.0003241305674191 0.0286320081271607 0.0 4768 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +893648 CD34 SELP CD34-SELP CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.007550960380283 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.1173076386135379 0.0004582650848664 0.0 0.0 0.0 0.0 4232 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +893667 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0075506898776557 0.4625081978296446 0.657421674383923 0.6198216015396206 0.0141498126994191 0.0069492509109592 0.0 0.0011695906432748 0.2001479813122162 0.0 285 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +893866 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.007548132689877 0.662063103571249 0.6331674633943454 0.7917001487310438 0.0236359933700329 0.0023576674662702 0.0 0.0002632687447346 0.0817276853978653 0.0 1187 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +893894 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.00754779947503 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0113788029360913 0.0041555861088636 0.0 0.0010162601626016 0.1290643339511056 0.0 246 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +893945 MMRN2 CD93 MMRN2-CD93 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.007547215643936 0.6301823358791634 0.7779918296243433 1.0 0.0031934983073077 0.0118035014556376 0.0 0.0003064303224589 0.0234770703347243 0.0 21212 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +893999 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.007546611568484 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0021291294377375 0.0293031867940321 0.0 0.000403368123834 0.0504817031362639 0.0 1803 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +894029 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0075461895097508 0.6160088550075702 0.4600037439857229 0.2461374514707439 0.0149256517769723 0.017738069381683 0.0 0.0003626692456479 0.0904171057226865 0.0 752 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +894045 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.007545944076758 0.8667347161816407 0.6614977577544194 0.7917001487310438 0.0106228227237899 0.0038288178384739 0.0 0.000390625 0.0730584038960404 0.0 1280 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +894145 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0075446899185308 0.8516956437178343 0.4641352222874551 0.7204611100467462 0.000472352586488 0.1370986982961073 0.0 0.0 0.0 0.0 66 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +894334 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0075424210013145 0.662063103571249 0.7167436199046466 0.6198216015396206 0.0236359933700329 0.0026482500471321 0.0 0.0002759381898454 0.1029666149943602 0.0 453 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +894385 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0075417643437143 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0021291294377375 0.0267210109213584 0.0 0.0005112723377318 0.0537213179699596 0.0 1867 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +894390 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0075416991936351 0.7487535481622718 0.7447682696221608 0.7827641335561659 0.0131092554497256 0.0032154705418133 0.0 0.0014690632561354 0.1247002451659558 0.0 526 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +894420 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0075412961282906 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.014525360548861 0.0066828239855783 0.0 0.0004268032437046 0.0525717720608996 0.0 1562 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +894429 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0075412219157589 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.0084325366891025 0.0053794918117879 0.0 0.0005897219882055 0.0636614215882142 0.0 1187 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +894479 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0075405041024496 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0126216524880575 0.0058437228618857 0.0 0.0002235636038452 0.0544910393530857 0.0 1278 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +894724 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0075375618146257 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0415873844357376 0.001079730675535 0.0 0.000501253132832 0.0771555020135354 0.0 570 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +894907 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0075352179235758 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0009692519480124 0.1076178292491983 0.0 0.0005790387955993 0.0485122925466048 0.0 157 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +894967 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0075344179437767 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0052560850129547 0.0124087765732037 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +895007 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0075340087343315 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.0026436039558049 0.0203874717835032 0.0 0.0006047714381047 0.0188925209591486 0.0 1332 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +895038 C1QB LRP1 C1QB-LRP1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0075336082372874 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0012213774841743 0.0501711964086628 0.0 0.0042438271604938 0.1010796466048214 0.0 162 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +895162 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0075320014725805 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0172764782878141 0.0058437228618857 0.0 0.0 0.0 0.0 6412 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +895481 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0075278267578713 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0008193633790489 0.0761275033764692 0.0 3.041085059149104e-05 0.0029288595635202 0.0 10961 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +895550 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0075269722341688 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0033973231723341 0.0144359394371152 0.0 0.0019614079728583 0.1716364949726902 0.0 262 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +895619 MMP2 PECAM1 MMP2-PECAM1 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0075260424378603 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0216588811659259 0.0023576674662702 0.0 0.0007139278557114 0.3423307002309592 0.0 1996 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +895733 CD48 CD2 CD48-CD2 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0075247467762936 0.7719609236370527 0.8581827408615759 0.6198216015396206 0.0112468593062777 0.003930762149527 0.0 0.0 0.0 0.0 30 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +895930 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0075225483506613 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0021291294377375 0.0484993884807927 0.0 0.001150747986191 0.0163595859908085 0.0 79 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +896030 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.007521241719057 0.7745997874735252 0.8998347793593909 0.6198216015396206 0.0065101973396288 0.0064362797035136 0.0 0.0004082465809348 0.1479171352462388 0.0 1633 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +896082 VWF ITGA9 VWF-ITGA9 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0075205297302321 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0003457348439318 0.1886404570313 0.0 0.0 0.0 0.0 126 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +896119 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0075201008824503 0.8023917560710954 0.6632137581773894 0.6198216015396206 0.0085367158000785 0.0064230792457803 0.0 0.0002069250931162 0.0278313633787714 0.0 659 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +896295 VEGFC FLT1 VEGFC-FLT1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0075179655670741 0.8963332422588541 0.4630488285702799 0.7204611100467462 0.0026007495851186 0.0232163927704059 0.0 0.0004662004662004 0.0912195597112214 0.0 715 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +896306 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0075178587483955 0.2491449441646273 0.6572093097629401 0.2461374514707439 0.0108445362943651 0.04130664769978 0.0 0.0 0.0 0.0 186 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +896392 CCN1 CAV1 CCN1-CAV1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0075169513778081 0.7797135509308979 0.62431395375366 0.6198216015396206 0.0009209869688402 0.0649213179279442 0.0 0.0008333333333333 0.0343344225331851 0.0 160 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +896468 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0075160076537972 0.4619393085577573 0.7167436199046466 0.2461374514707439 0.0835287751665837 0.0026482500471321 0.0 0.000243227061817 0.0907604244427163 0.0 13362 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +896510 VWF LRP1 VWF-LRP1 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0075154918194504 0.9011206516381156 0.6207977546603366 0.6198216015396206 0.0008850282134344 0.0587195251380622 0.0 0.0001241570390506 0.0129119319418904 0.0 1739 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +896528 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0075152638828948 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0308750930304183 0.0032187363284526 0.0 0.0004001280409731 0.0788172595451358 0.0 1562 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +896595 CD48 CD2 CD48-CD2 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0075144473753897 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0112468593062777 0.0062523288579129 0.0 0.0 0.0 0.0 50 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +896810 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells 0.0075113934775699 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0020491452254277 0.02871400543887 0.0 3.998852742937198e-05 0.0193510552450552 0.0 30217 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +897087 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0075081142022149 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0037159398684439 0.0118035014556376 0.0 0.0 0.0 0.0 69 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +897185 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0075067350050456 0.6605327397359113 0.8381155706134242 0.6198216015396206 0.0179229861158654 0.0029095741067474 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +897266 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0075055029986027 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.002196330917593 0.0446401662952339 0.0 0.0017814726840855 0.1612203835245692 0.0 1684 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +897488 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.007502458824465 0.7797135509308979 0.62431395375366 0.6198216015396206 0.0009209869688402 0.0641739251983978 0.0 0.0012345679012345 0.1172779928364539 0.0 162 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +897756 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0074991751799327 0.7719609236370527 0.937587088419394 0.6198216015396206 0.0014378253178126 0.0275738893167071 0.0 0.0012642225031605 0.0527286195865297 0.0 791 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +897826 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0074982560338771 0.6303642896310324 0.6331674633943454 0.8693461273411047 0.0104129581710415 0.0049190726392343 0.0 0.0002777777777777 0.0339308980504999 0.0 270 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +897955 CD48 CD2 CD48-CD2 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0074967467904483 0.4593282471594782 0.4603649459881741 0.8293805866303694 0.0161888123016941 0.0062523288579129 0.0 0.0091324200913242 0.1079385378836943 0.0 219 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +898011 CCN1 CAV1 CCN1-CAV1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.007495799573621 0.7797135509308979 0.62431395375366 0.6198216015396206 0.0009209869688402 0.0638329144736252 0.0 0.0002599653379549 0.0678661231478083 0.0 1154 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +898208 CD48 CD2 CD48-CD2 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0074930681264603 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0467114894617178 0.0014748371602574 0.0 0.0 0.0 0.0 48 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +898435 C3 LRP1 C3-LRP1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0074903551931047 0.9487258305485792 0.2550748532138862 0.2461374514707439 0.0110943464444434 0.0267255153180908 0.0 0.0006653992395437 0.1053496510663995 0.0 263 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +898596 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0074883416924552 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0021291294377375 0.0279580382843415 0.0 0.0004298302170642 0.0602744863387814 0.0 1692 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +898830 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0074854919265575 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0065101973396288 0.0066828239855783 0.0 0.0 0.0 0.0 2359 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +898884 CCN1 CAV1 CCN1-CAV1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.007484847904936 0.6213271600240247 0.943345641464811 0.6198216015396206 0.013905026986541 0.0034806998160403 0.0 0.0001063829787234 0.0393837977387811 0.0 1880 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +898906 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0074845734168119 0.7158082793127664 0.7292496872084557 0.8767341187813953 0.0071496754272206 0.0053724660607752 0.0 0.0001482414853796 0.0143184248469467 0.0 2453 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +898989 VWF LRP1 VWF-LRP1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0074835640754629 0.9011206516381156 0.7346293219749174 0.7204611100467462 0.0008850282134344 0.0416128058995347 0.0 0.000588048315321 0.0243819069127592 0.0 715 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +899082 CD48 CD2 CD48-CD2 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0074826328076487 0.7453966474499909 0.4603649459881741 0.7204611100467462 0.006326966401379 0.0112209532878862 0.0 0.0003840245775729 0.0754539528625168 0.0 1302 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +899084 C1QB LRP1 C1QB-LRP1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0074826305792529 0.7452691992612583 0.6207977546603366 0.6198216015396206 0.0012199377895337 0.0501711964086628 0.0 0.0121323529411764 0.2889688720584894 0.0 170 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +899322 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0074799506266819 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.0003521782369754 0.1347191569099048 0.0 0.0 0.0 0.0 345 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +899457 VWF ITGA9 VWF-ITGA9 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0074783187660758 0.9011206516381156 0.6252253442669611 0.6198216015396206 0.0008850282134344 0.0565946652887153 0.0 0.0003357056532832 0.012417843132618 0.0 1354 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +899476 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0074780437864561 0.6342079770588467 0.4641352222874551 0.2461374514707439 0.0053032910137447 0.0455121851821151 0.0 0.0 0.0 0.0 877 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +899688 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0074755817104348 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.000716220684292 0.0627790816848129 0.0 0.0 0.0 0.0 193 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +899733 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0074750009909979 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0186793449598515 0.0032020139126304 0.0 0.0 0.0 0.0 135 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +899860 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0074734498622003 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0048525806497539 0.0104714078116759 0.0 0.0008904837852206 0.0876274184352088 0.0 1881 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +900034 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0074711361764709 0.6160088550075702 0.6632137581773894 0.8824495942126559 0.0009692519480124 0.049767778498468 0.0 0.0001164441706545 0.039794268204849 0.0 12101 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +900050 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.007470874426696 0.9067635403815892 0.2491073778594529 0.2461374514707439 0.0411127335336962 0.0076066460958003 0.0 0.000289156626506 0.1220357022058508 0.0 2075 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +900132 CD48 CD2 CD48-CD2 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0074698534113602 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0081474500750471 0.0112209532878862 0.0 0.0 0.0 0.0 1323 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +900346 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.00746733429397 0.2491449441646273 0.7760344326192508 0.2461374514707439 0.0108445362943651 0.0335947364052305 0.0 0.0 0.0 0.0 316 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +900518 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.007465009454015 0.7475533330314548 0.7467524951532132 1.0 0.0029751676683741 0.0104195741475089 0.0 0.0039752650176678 0.2742932862190813 0.0 1132 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +900538 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0074647314853682 0.6213271600240247 0.252518874138558 0.2461374514707439 0.013905026986541 0.0322196586137726 0.0 0.0001740644038294 0.0304606003417254 0.0 383 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +900590 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0074639484234927 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0072827533047186 0.0064028969591119 0.0 0.0003687315634218 0.0436326253464484 0.0 339 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +900637 CD34 SELP CD34-SELP Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.007463379105149 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0042829523358709 0.0222228052993653 0.0 0.0001498800959232 0.0400499812926811 0.0 3336 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +900741 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0074617983883682 0.6630837220165452 0.8347945881127203 0.6198216015396206 0.0415873844357376 0.0012097093680331 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +900807 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0074609506182819 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0526353932596327 0.0008609682710384 0.0 0.0023177412557943 0.6953443534877843 0.0 339 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +900838 C3 LRP1 C3-LRP1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0074605747954417 0.8509500867818902 0.8604147465201248 0.8567148457705164 0.0006305085967044 0.0436001007095475 0.0 0.0027272727272727 0.0779706839226403 0.0 165 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +901398 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0074534358051584 0.9184503888425788 0.7754072541855492 0.6198216015396206 0.0004696576149175 0.0826982152707935 0.0 0.0 0.0 0.0 1332 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +901482 A2M LRP1 A2M-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0074524643052626 0.7460047258226694 0.6207977546603366 0.6198216015396206 0.0010163752993685 0.0587195251380622 0.0 7.221259387637204e-05 0.0092851381770282 0.0 1154 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +901859 CCN1 CAV1 CCN1-CAV1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0074479843718168 0.8619922139338987 0.62431395375366 0.6198216015396206 0.0054092055025683 0.009460730808256 0.0 9.879470460383324e-05 0.0122659584728511 0.0 1687 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +901863 VWF LRP1 VWF-LRP1 Myoepithelial Cells Endothelial Cells Myoepithelial Cells -> Endothelial Cells 0.0074479514083899 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0025256125075084 0.0144359394371152 0.0 0.0005107820528381 0.0451198293469088 0.0 2247 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +902058 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0074454558612332 0.2490567623945399 0.6580560501976399 0.2461374514707439 0.011649387573427 0.0362497659817488 0.0 0.0 0.0 0.0 26 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +902068 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0074452749526021 0.8284725546778968 0.7167436199046466 0.7204611100467462 0.0012187708721425 0.0326667674102811 0.0 0.0075 0.1587664893290385 0.0 50 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +902205 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0074436595457555 0.8023917560710954 0.7757991160529997 0.7204611100467462 0.0085367158000785 0.0044430418127202 0.0 0.0083732057416267 0.312999757094743 0.0 38 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +902339 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0074418829799667 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0073929685753755 0.0069630688870869 0.0 0.0 0.0 0.0 2400 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +902407 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0074410648454171 0.7160288858520609 0.8818120773736414 0.7204611100467462 0.0069047442087267 0.0054043611446182 0.0 0.0 0.0 0.0 591 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +902496 A2M LRP1 A2M-LRP1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0074397005518456 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.0149044683666724 0.0032275631628407 0.0 0.0004675081813931 0.0276091883050739 0.0 713 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +902613 CCN1 CAV1 CCN1-CAV1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0074380287848105 0.7324582304061453 0.7283139964676212 1.0 0.0025580826958339 0.0124087765732037 0.0 0.0009422850412249 0.046454288326308 0.0 283 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +902978 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0074334112988244 0.8949858186325867 0.6571792026963191 0.6198216015396206 0.001895566065636 0.0244129856070659 0.0 0.0 0.0 0.0 129 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +903166 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0074314407243617 0.7160288858520609 0.4641352222874551 0.8767341187813953 0.0012306151710811 0.046975263367762 0.0 0.0008163265306122 0.1350525273220226 0.0 2450 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +903280 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.007430014297802 0.6160088550075702 0.9460955677032749 0.7917001487310438 0.0009692519480124 0.0376195773145198 0.0 0.0021645021645021 0.0787528534080533 0.0 42 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +903387 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0074285243352395 0.6342079770588467 0.7746834992804791 1.0 0.0073929685753755 0.0046263543438723 0.0 0.000133572191841 0.0728142267687622 0.0 21212 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +903779 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0074236568846822 0.6561647292424944 0.6207977546603366 1.0 0.0142750905665976 0.0028784826949613 0.0 0.0009128006872852 0.147549054514699 0.0 1552 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +903989 A2M LRP1 A2M-LRP1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0074208043183808 0.7460047258226694 0.7346293219749174 0.7204611100467462 0.0010163752993685 0.0416128058995347 0.0 0.0 0.0 0.0 85 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +904043 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.007420183946229 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0016575843792215 0.0222186841038061 0.0 0.001291911423323 0.0510860596365135 0.0 2359 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +904045 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0074201739962167 0.7487535481622718 0.8622452992050237 0.6198216015396206 0.0016417770622885 0.0254056950469408 0.0 0.0 0.0 0.0 30 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +904089 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0074195568928192 0.7160288858520609 0.7480927101953669 0.7204611100467462 0.0069047442087267 0.006260692484444 0.0 0.0 0.0 0.0 51 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +904194 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0074181651383071 0.6561647292424944 0.9078204025796472 0.6198216015396206 0.0070489045197697 0.0064028969591119 0.0 0.000548245614035 0.0771832474209091 0.0 380 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +904348 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0074161831607742 0.6301823358791634 0.7830372268649692 0.6198216015396206 0.0208904415011529 0.0026038611777234 0.0 0.0004409171075837 0.0375209756414257 0.0 756 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +904443 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0074149900606086 0.785133132759182 0.6331674633943454 0.6198216015396206 0.001039571291679 0.0518891167572028 0.0 0.0008823529411764 0.0322153779060066 0.0 170 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +904469 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0074146526305441 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.000245041593909 0.1886404570313 0.0 0.0003412503412503 0.0089247993000507 0.0 1332 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +904626 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0074127867833831 0.6303642896310324 0.6331674633943454 0.8824495942126559 0.0014431743145616 0.0326412663903893 0.0 9.709941327163045e-05 0.039342293459707 0.0 12101 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +904660 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0074123522521395 0.6561647292424944 0.8755243548400705 0.6198216015396206 0.112230917768503 0.0004150165744076 0.0 0.0 0.0 0.0 42 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +904770 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0074107482208927 0.8718210606749883 0.6593689120110077 0.6198216015396206 0.0017670878089588 0.026308073552735 0.0 0.0004273504273504 0.0311469739222534 0.0 390 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +904874 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0074096182558106 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0071496754272206 0.0083442542366581 0.0 0.0003866643753222 0.0212850626786769 0.0 4232 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +904951 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.007408624965011 0.743507317541692 0.6593689120110077 0.6198216015396206 0.0020684923107111 0.026308073552735 0.0 0.0111111111111111 0.8098213219785908 0.0 30 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +905151 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0074058719778273 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0051428381563772 0.0176963220730796 0.0 0.0013280212483399 0.2427682582981902 0.0 753 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +905389 VEGFC FLT1 VEGFC-FLT1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0074032147579564 0.4636527906642655 0.777821334064334 0.6198216015396206 0.0023125636768155 0.0318483483218543 0.0 0.0006640106241699 0.0840315202863846 0.0 753 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +905391 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0074031859699288 0.6160088550075702 0.7462743270426613 0.6198216015396206 0.0255753403203798 0.0022591041672132 0.0 0.0016368672878368 0.1818863578729388 0.0 361 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +905419 VWF ITGA9 VWF-ITGA9 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0074029424797339 0.7158082793127664 0.8794572885381431 0.7204611100467462 0.0003457348439318 0.104965956217838 0.0 0.0002697599136768 0.006045955313797 0.0 337 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +905455 C3 LRP1 C3-LRP1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0074024305924653 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.0029337538459309 0.0203874717835032 0.0 0.0023809523809523 0.3045510334036485 0.0 126 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +905641 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.007400157203805 0.6213271600240247 0.252518874138558 0.2461374514707439 0.2247035641022029 0.0018925243453249 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +905742 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0073990312553537 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.0201572483258557 0.0043013567716651 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +905747 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0073988795979087 0.8730912658940219 0.6632137581773894 0.6198216015396206 0.0057086106530109 0.0080072638027924 0.0 0.0007974481658692 0.1926242870964067 0.0 285 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +905830 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0073980571176033 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0161193721503025 0.0032187363284526 0.0 0.0011127596439169 0.3237425348324813 0.0 2359 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +905843 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0073977799621949 0.255669001367946 0.9546923450729716 0.2461374514707439 0.0061207051981986 0.0445745465878424 0.0 0.0005165289256198 0.019129735948472 0.0 176 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +905857 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Dendritic Cells 11q13 Invasive Tumor Cells -> Dendritic Cells 0.0073975936696165 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0131302879503246 0.0032078747392388 0.0 5.411255411255411e-05 0.0089792945144412 0.0 3360 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +906127 CD48 CD2 CD48-CD2 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0073937022601589 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0212837736082081 0.0024251058581756 0.0 0.0 0.0 0.0 1354 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +906131 MMP2 PECAM1 MMP2-PECAM1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0073936569998497 0.6303642896310324 0.6331674633943454 0.9318789094584046 0.0024819960935566 0.0176963220730796 0.0 0.0006770310932798 0.0896717927305618 0.0 4985 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +906198 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0073929365093247 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.0051524613572059 0.0090444648829713 0.0 0.0 0.0 0.0 271 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +906221 A2M LRP1 A2M-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0073926409052044 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.0149044683666724 0.0028784826949613 0.0 0.0 0.0 0.0 97 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +906231 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0073925356961108 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0137371823984124 0.0062523288579129 0.0 0.1 1.0 0.0 5 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +906268 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0073919317674298 0.6213271600240247 0.8818704453527788 0.6198216015396206 0.0093830613230477 0.0051192928876727 0.0 0.0003236245954692 0.0609691648905713 0.0 103 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +906451 A2M LRP1 A2M-LRP1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0073894616529199 0.7741139100414175 0.8755243548400705 0.6198216015396206 0.093381536992618 0.0004150165744076 0.0 0.0013796909492273 0.2006823198876179 0.0 151 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +906537 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0073884585013528 0.7160288858520609 0.8923034233058523 0.7204611100467462 0.0186793449598515 0.00189193058407 0.0 8.300132802124833e-05 0.0367195100153129 0.0 10040 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +906559 CD34 SELP CD34-SELP B Cells Pericytes B Cells -> Pericytes 0.0073881170827827 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0006336851232098 0.0741032966028748 0.0 0.0 0.0 0.0 1211 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +906678 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0073864358215422 0.6561647292424944 0.8755243548400705 0.6198216015396206 0.1098969873322313 0.0004150165744076 0.0 0.0032051282051282 0.4662004662004662 0.0 130 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +906732 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0073858176298204 0.6332974881236617 0.6207977546603366 1.0 0.0020251995753771 0.0203874717835032 0.0 0.0001079707991232 0.0050554916596539 0.0 19576 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +906788 C3 LRP1 C3-LRP1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0073851054217424 0.6319926036888139 0.6207977546603366 0.9318789094584046 0.0042375227960614 0.0104714078116759 0.0 0.0007622868605817 0.0750122919793632 0.0 4985 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +907169 VWF SELP VWF-SELP Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0073801206949675 0.7848266128497919 0.8819126042133903 0.7827641335561659 0.0004024409845247 0.0741032966028748 0.0 0.0012853470437017 0.0296458135515062 0.0 389 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +907183 COL4A2 CD93 COL4A2-CD93 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.007379936013199 0.9188764516910942 0.4630027772793905 0.7204611100467462 0.0090193130488293 0.0058437228618857 0.0 0.0006993006993006 0.2122098254959498 0.0 715 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +907426 CD48 CD2 CD48-CD2 Macrophages Mast Cells Macrophages -> Mast Cells 0.0073770065704234 0.7719609236370527 0.7763428264267787 0.8567148457705164 0.0212837736082081 0.0014748371602574 0.0 0.0 0.0 0.0 165 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +907458 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0073766160302578 0.7487535481622718 0.8622452992050237 0.6198216015396206 0.0015847932820241 0.0254056950469408 0.0 0.0 0.0 0.0 162 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +907508 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0073757557479181 0.7745997874735252 0.7472387841445823 0.6198216015396206 0.0065101973396288 0.0068935067166085 0.0 0.0041407867494824 0.2517848176682676 0.0 161 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +907598 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.007374745897954 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0002327631000826 0.1993723722552783 0.0 0.001325381047051 0.0491043411302484 0.0 1509 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +907600 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.007374734612449 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.016822895653248 0.0043013567716651 0.0 0.0009350163627863 0.0741571048359488 0.0 713 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +907605 HSPG2 LRP1 HSPG2-LRP1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0073746885882502 0.9253089325030373 0.6207977546603366 0.6198216015396206 0.0022161183602947 0.0203874717835032 0.0 0.0005845491956603 0.0182607961203892 0.0 594 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +907614 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0073745838958944 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0008193633790489 0.0467761235673353 0.0 0.000842815002107 0.0473961806057477 0.0 791 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +907727 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0073729767818288 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.002676946692949 0.0176963220730796 0.0 0.0 0.0 0.0 1881 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +907858 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0073711371126206 0.6213271600240247 0.62431395375366 0.9592803095773328 0.0052560850129547 0.0082011408892332 0.0 0.0005645889792231 0.0946876960989 0.0 1476 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +907874 CD48 CD2 CD48-CD2 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0073709307147213 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0351142257737683 0.0024251058581756 0.0 0.0 0.0 0.0 1673 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +907882 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0073708468534806 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0009153913192522 0.0587195251380622 0.0 6.59862748548302e-05 0.0056237044965393 0.0 5683 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +907888 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0073707751468203 0.4629984640915818 0.8604147465201248 0.7204611100467462 0.0012814156885439 0.0436001007095475 0.0 0.0021430926475436 0.0492497956881896 0.0 337 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +907918 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0073703986074957 0.6342079770588467 0.8818120773736414 0.6198216015396206 0.0085570823799139 0.0054043611446182 0.0 0.0 0.0 0.0 103 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +907921 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0073703441616789 0.7158082793127664 0.7831795333113832 0.7204611100467462 0.0071496754272206 0.0055509879377996 0.0 6.881838827334664e-05 0.0051322495929847 0.0 1321 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +907963 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0073698066534692 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.1194227711616854 0.0007400708115376 0.0 0.0 0.0 0.0 135 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +908004 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0073692551224441 0.7205550478301406 0.7830372268649692 0.7204611100467462 0.0151307911035231 0.0026038611777234 0.0 0.0 0.0 0.0 51 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +908172 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0073673072472275 0.8516956437178343 0.7754072541855492 0.6198216015396206 0.000472352586488 0.0826982152707935 0.0 0.0 0.0 0.0 30 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +908179 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0073671739051479 0.6249837837987587 0.8923034233058523 0.6198216015396206 0.0244483651952677 0.00189193058407 0.0 0.0008090614886731 0.305295080391222 0.0 103 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +908228 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0073666015131899 0.8533682807143209 0.4630027772793905 0.6198216015396206 0.0706049302656684 0.0009242223287825 0.0 0.0 0.0 0.0 79 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +908586 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0073623584701335 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.0673400749834054 0.0006074333625108 0.0 0.0 0.0 0.0 570 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +908704 COL4A2 CD93 COL4A2-CD93 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0073608933743972 0.7783550150988336 0.7779918296243433 0.909150863993142 0.0267593032157803 0.001079730675535 0.0 0.0004452926208651 0.075305813549985 0.0 1572 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +908728 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0073605494873435 0.9219165193585238 0.252518874138558 0.2461374514707439 0.0086134406931133 0.0322196586137726 0.0 0.0005812653699977 0.1017192012752857 0.0 1491 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +908746 C3 LRP1 C3-LRP1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0073603569829628 0.7796725988275006 0.9078204025796472 0.7827641335561659 0.000819605673545 0.0350138403862125 0.0 0.0001928020565552 0.0169369900005341 0.0 389 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +908750 VWF LRP1 VWF-LRP1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0073602988875117 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0003457348439318 0.166956519448744 0.0 0.0017942583732057 0.0135193105584365 0.0 285 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +908788 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0073597999528594 0.633566764858408 0.6572093097629401 1.0 0.0083565457974945 0.0045674276780054 0.0 0.0009664948453608 0.2952415186059043 0.0 1552 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +908899 MMP2 PECAM1 MMP2-PECAM1 Macrophages B Cells Macrophages -> B Cells 0.007358131575202 0.9330801352629944 0.6331674633943454 0.6198216015396206 0.0088108219576754 0.0049190726392343 0.0 0.0013268156424581 0.162072166665796 0.0 1074 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +909195 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0073542641303351 0.4625081978296446 0.657421674383923 0.6198216015396206 0.0141498126994191 0.0059327142047454 0.0 0.0 0.0 0.0 8 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +909237 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0073535509196151 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0106922602624424 0.0041555861088636 0.0 0.0005128205128205 0.0974350825485819 0.0 390 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +909403 MMP2 PECAM1 MMP2-PECAM1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0073513816193978 0.9067635403815892 0.7841656220878274 0.7827641335561659 0.0216588811659259 0.001309307002134 0.0 0.0002373417721518 0.0283873294158607 0.0 316 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +909578 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0073490949114292 0.6342079770588467 0.7480927101953669 0.6198216015396206 0.0085570823799139 0.006260692484444 0.0 0.0 0.0 0.0 23 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +909657 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0073481992239328 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0323110954490285 0.0021449819680126 0.0 0.0238095238095238 0.8640939597315438 0.0 5 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +909658 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Macrophages B Cells -> Macrophages 0.0073481884092861 0.7800321422220979 0.9015117569158254 0.6198216015396206 0.0014623066995027 0.0246995741084876 0.0 0.0007042253521126 0.0678543830764569 0.0 1065 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +909831 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0073461639378652 0.6561647292424944 0.2550748532138862 0.2461374514707439 0.0142750905665976 0.0267255153180908 0.0 0.0009496676163342 0.0826091289414193 0.0 351 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +909861 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0073458102777196 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0016171311116606 0.0309945332907452 0.0 0.0001185770750988 0.0073967052547698 0.0 2300 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +910076 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.007343292595847 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0131092554497256 0.0038860320327025 0.0 0.0 0.0 0.0 409 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +910359 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0073395979697086 0.8771078809726828 0.7746834992804791 0.6198216015396206 0.0080232294691882 0.0046263543438723 0.0 0.0001631245339299 0.0573841404071402 0.0 3576 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +910366 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0073395335985451 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0009153913192522 0.0416128058995347 0.0 0.0002653927813163 0.0105145612731878 0.0 1884 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +910666 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0073356863769185 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0131092554497256 0.0038621268649178 0.0 0.0 0.0 0.0 390 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +910676 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0073355865124107 0.7856500335676843 0.944024288971064 0.7827641335561659 0.0005542667491398 0.0484215930647349 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +910713 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells 0.0073351054948294 0.6301823358791634 0.6587114738285964 0.8824495942126559 0.00146889578236 0.0289462771086338 0.0 0.0001290433585684 0.026685294734072 0.0 5812 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +910750 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.00733469792093 0.2490567623945399 0.4641352222874551 0.2461374514707439 0.011649387573427 0.046975263367762 0.0 0.0 0.0 0.0 4879 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +910762 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0073345739565029 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0061207051981986 0.0521257226458961 0.0 0.002047502047502 0.0856313572557282 0.0 222 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +910908 CD48 CD2 CD48-CD2 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0073329231059497 0.4593282471594782 0.8581827408615759 0.6198216015396206 0.0161888123016941 0.003930762149527 0.0 0.0003636363636363 0.0974925295569702 0.0 6875 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +911568 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0073240124665486 0.7783550150988336 0.8347945881127203 0.6198216015396206 0.0316800311254893 0.0012097093680331 0.0 0.0003003003003003 0.0177733833467226 0.0 333 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +911610 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0073234362615244 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0055862851962672 0.0056518532344078 0.0 6.634819532908705e-05 0.0549754702863617 0.0 1884 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +911720 VWF SELP VWF-SELP Myoepithelial Cells CAFs, DCIS Associated Myoepithelial Cells -> CAFs, DCIS Associated 0.0073218604488918 0.7158082793127664 0.4623922682986163 0.8293805866303694 0.0025256125075084 0.0222228052993653 0.0 7.578915457198075e-05 0.0125498856007357 0.0 7197 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +911761 THBS2 CD36 THBS2-CD36 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0073212618940206 0.6242573126045354 0.6176321640000088 1.0 0.0063387366560491 0.0063011237754475 0.0 0.000159108052046 0.0321055568239033 0.0 21212 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +911762 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0073212343751783 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0342558468646473 0.0021449819680126 0.0 0.0035653855450809 0.1293947807719824 0.0 394 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +911764 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0073211695909936 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.0085570823799139 0.0046263543438723 0.0 0.0 0.0 0.0 83 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +911767 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0073211332004922 0.4601010570874773 0.7346293219749174 0.8293805866303694 0.0170183763647696 0.0032275631628407 0.0 0.0011415525114155 0.0454925500018594 0.0 219 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +911779 VWF LRP1 VWF-LRP1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0073209829537395 0.9011206516381156 0.6207977546603366 0.6198216015396206 0.0008850282134344 0.0501711964086628 0.0 0.0005186721991701 0.0105148507551939 0.0 1687 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +911871 VWF ITGA9 VWF-ITGA9 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0073198061155213 0.6332974881236617 0.6252253442669611 0.8693461273411047 0.00023686843287 0.1886404570313 0.0 0.0 0.0 0.0 360 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +911897 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0073194234517839 0.6630837220165452 0.4630027772793905 0.2461374514707439 0.0415873844357376 0.0048929293424311 0.0 0.0011645962732919 0.3133847771016165 0.0 184 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +912552 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.007311033035256 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0052560850129547 0.009460730808256 0.0 0.0008635578583765 0.1072159168067354 0.0 193 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +912570 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0073108346286762 0.250044481781731 0.6347970925105053 0.2461374514707439 0.0070431301838115 0.0554888093272979 0.0 0.0 0.0 0.0 186 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +912661 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0073098684913983 0.6342079770588467 0.7470475610360806 0.6198216015396206 0.0673400749834054 0.0007714919761827 0.0 0.0004409171075837 0.1279040184869604 0.0 756 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +912997 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0073053349538262 0.7148920381722296 0.2550748532138862 0.2461374514707439 1.0 0.0003386430177035 0.0 0.0006521739130434 0.067597382479134 0.0 230 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +913029 CD48 CD2 CD48-CD2 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0073049480405011 0.7719609236370527 0.4603649459881741 0.2461374514707439 0.0164675938709007 0.0105486447632276 0.0 0.0002409638554216 0.0447566361334637 0.0 2075 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +913090 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0073042316339278 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0097699360831605 0.0049190726392343 0.0 8.771929824561404e-05 0.0107150204369999 0.0 570 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +913121 DLL4 NOTCH3 DLL4-NOTCH3 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0073038759606703 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0002327631000826 0.1973932010691654 0.0 0.0008608815426997 0.0154078218909471 0.0 968 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +913196 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0073029966584089 0.662063103571249 0.2491073778594529 0.2461374514707439 0.0491302556793708 0.0076066460958003 0.0 0.001068376068376 0.4450936272521989 0.0 351 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +913342 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0073010310010998 0.4636527906642655 0.4630488285702799 0.2461374514707439 0.0666348171285698 0.0043013567716651 0.0 0.0049019607843137 0.3887795275590555 0.0 272 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +913431 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0072998702792231 0.7160288858520609 0.4638256179742202 0.8293805866303694 0.0012306151710811 0.0446401662952339 0.0 0.0 0.0 0.0 324 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +913440 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0072997567142162 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0015572459193676 0.0309945332907452 0.0 0.0 0.0 0.0 83 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +913490 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0072991371746445 0.4619393085577573 0.930308383061206 0.7204611100467462 0.1194227711616854 0.0004089864655001 0.0 7.625272331154683e-05 0.0980083062159151 0.0 11475 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +913504 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0072989907252798 0.6319926036888139 0.6207977546603366 0.8693461273411047 0.0265972645862203 0.0016667952436519 0.0 0.0 0.0 0.0 270 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +913636 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0072972575535499 0.662063103571249 0.930308383061206 0.6198216015396206 0.0967042147306326 0.0004089864655001 0.0 0.0 0.0 0.0 1490 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +913641 C3 LRP1 C3-LRP1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0072972012088522 0.7148920381722296 0.9078204025796472 0.7204611100467462 0.005043231651446 0.0064028969591119 0.0 4.8764629388816654e-05 0.0092386556456046 0.0 1538 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +913815 VWF ITGA9 VWF-ITGA9 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.007294996122689 0.9011206516381156 0.6252253442669611 0.6198216015396206 0.0008850282134344 0.0487643047611538 0.0 5.388802069299995e-05 0.0021093308260619 0.0 1687 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +913821 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0072948962671843 0.6626993710110988 0.2550748532138862 0.2461374514707439 0.0135527119637784 0.0267255153180908 0.0 0.0016129032258064 0.1003375998814473 0.0 155 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +913988 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0072926779917929 0.4629984640915818 0.7346293219749174 0.8293805866303694 0.0012814156885439 0.0416128058995347 0.0 0.0007287379972565 0.0240635224121703 0.0 324 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +914001 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0072924818705272 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0084812136822336 0.0046263543438723 0.0 0.0 0.0 0.0 69 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +914240 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0072896375128777 0.8640667164982425 0.7167436199046466 0.7204611100467462 0.002676946692949 0.0125623889131764 0.0 5.1318310373141134e-05 0.0238262640996107 0.0 10961 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +914268 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0072892770340992 0.893316592628645 0.6347970925105053 0.6198216015396206 0.0007691101630988 0.0554888093272979 0.0 9.584052137243626e-05 0.0156849926574646 0.0 1739 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +914309 CD34 SELP CD34-SELP T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0072887651242182 0.633566764858408 0.4623922682986163 0.6198216015396206 0.015517736049123 0.0053213839468185 0.0 0.0003912363067292 0.1532480409447081 0.0 1278 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +914493 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0072863910339793 0.7835752212271604 0.8818326005152037 0.7827641335561659 0.0064863313435223 0.0042655619249233 0.0 0.0 0.0 0.0 527 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +914513 COL4A1 CD93 COL4A1-CD93 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0072861959751891 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0126216524880575 0.0026174949623928 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +914534 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0072858635789121 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0009692519480124 0.0521257226458961 0.0 0.0026478375992939 0.1107388037520679 0.0 103 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +914586 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0072853129492662 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0265972645862203 0.0018097844702233 0.0 0.0003439380911435 0.121454863646213 0.0 1163 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +914860 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0072821588662092 0.4629984640915818 0.6207977546603366 0.2461374514707439 0.0201301851612071 0.0104714078116759 0.0 0.0009669479606188 0.0808242510228807 0.0 316 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +914943 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0072809688448532 0.6160088550075702 0.6632137581773894 0.8824495942126559 0.0106340017102282 0.0038860320327025 0.0 0.0001021025563454 0.057757287323438 0.0 12020 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +915061 C1QB LRP1 C1QB-LRP1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0072794028764313 0.8703788833238396 0.2550748532138862 0.2461374514707439 0.8040181448318822 0.0003386430177035 0.0 0.0183333333333333 1.0 0.0 75 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +915184 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0072779801017291 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0172764782878141 0.0026174949623928 0.0 0.0005859375 0.1946118767396442 0.0 1280 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +915479 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0072743255802246 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0117842887908422 0.0042738820064046 0.0 0.0 0.0 0.0 1673 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +915511 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0072740974853315 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0117842887908422 0.0044340558155446 0.0 0.0 0.0 0.0 233 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +915555 C1QB LRP1 C1QB-LRP1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.007273672592389 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0111808254589153 0.0032275631628407 0.0 0.0001586294416243 0.0063216170370604 0.0 394 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +915566 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0072734271811754 0.6160088550075702 0.6631822525600675 0.8824495942126559 0.0106340017102282 0.0038621268649178 0.0 0.0001103358013042 0.0682005853941702 0.0 11947 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +915628 CCN1 CAV1 CCN1-CAV1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0072727227708801 0.8619922139338987 0.62431395375366 0.6198216015396206 0.0054092055025683 0.0082011408892332 0.0 0.0 0.0 0.0 129 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +915676 THBS2 CD36 THBS2-CD36 Mast Cells Macrophages Mast Cells -> Macrophages 0.0072721142629051 0.8581959463413404 0.8587566561291643 0.8567148457705164 0.0002636300075004 0.088850508457521 0.0 0.0005050505050505 0.0098637903925663 0.0 165 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +915696 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.007271824077372 0.2490567623945399 0.4638256179742202 0.2461374514707439 0.011649387573427 0.0446401662952339 0.0 0.0006735518634934 0.0609553493164289 0.0 13362 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +915773 CD48 CD2 CD48-CD2 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0072709207471155 0.4593282471594782 0.7464347811605867 0.7204611100467462 0.0467114894617178 0.0012805120781881 0.0 0.0 0.0 0.0 43 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +915837 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0072701423976176 0.6319926036888139 0.6207977546603366 0.8824495942126559 0.0007263013575398 0.0587195251380622 0.0 0.0001218907528303 0.029417430384259 0.0 12101 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +915879 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.007269612374252 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.018132161410931 0.0043013567716651 0.0 0.0 0.0 0.0 253 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +916243 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0072650790754645 0.6626993710110988 0.6207977546603366 0.9161861017439124 0.0135527119637784 0.0028784826949613 0.0 0.0003564638783269 0.0303188124304417 0.0 526 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +916317 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.007264169299262 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0061207051981986 0.0491709261488903 0.0 0.0004095004095004 0.0184797192886492 0.0 222 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +916463 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0072622576553807 0.7468485855611411 0.8604147465201248 0.7827641335561659 0.0006689050756654 0.0436001007095475 0.0 0.0020576131687242 0.0472854163729912 0.0 162 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +916521 MMRN2 CD93 MMRN2-CD93 Dendritic Cells 11q13 Invasive Tumor Cells Dendritic Cells -> 11q13 Invasive Tumor Cells 0.0072613875753537 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0015409900107563 0.0289462771086338 0.0 0.0 0.0 0.0 3945 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +916551 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0072610231062308 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0323110954490285 0.0008542071298387 0.0 0.0018796992481203 0.3471700381736753 0.0 38 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +916598 CCN1 CAV1 CCN1-CAV1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0072603350594411 0.6213271600240247 0.62431395375366 0.7917001487310438 0.013905026986541 0.0034299077593249 0.0 0.0004115226337448 0.042571306939123 0.0 81 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +916641 CD34 SELP CD34-SELP Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0072596470513012 0.7168245244832976 0.4623922682986163 1.0 0.0082993421103349 0.0053213839468185 0.0 6.708107866374491e-05 0.0262757921820138 0.0 22361 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +916645 A2M LRP1 A2M-LRP1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0072595866581849 0.7460047258226694 0.6207977546603366 0.6198216015396206 0.0010163752993685 0.0501711964086628 0.0 0.0 0.0 0.0 170 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +916736 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.007258250678191 0.662063103571249 0.6331674633943454 0.9592803095773328 0.0491302556793708 0.0007400708115376 0.0 0.0002508361204013 0.0489608568149942 0.0 1495 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +916754 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0072580001127114 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0351142257737683 0.0016204239758814 0.0 0.0001992031872509 0.036110610144621 0.0 10040 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +916809 C3 LRP1 C3-LRP1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0072573770038853 0.8509500867818902 0.9078204025796472 0.8567148457705164 0.0006305085967044 0.0350138403862125 0.0 0.0024590163934426 0.2160160364002551 0.0 244 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +916829 CD48 CD2 CD48-CD2 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0072570759123872 0.7453966474499909 0.7763428264267787 0.7827641335561659 0.006326966401379 0.0050968401714881 0.0 0.0010869565217391 0.276623793165317 0.0 460 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +916830 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0072570673007169 0.7487535481622718 0.7754239189773715 0.8567148457705164 0.0016417770622885 0.0178869147172998 0.0 0.000494071146245 0.0844621735737192 0.0 276 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +916859 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0072566775832951 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.000245041593909 0.166956519448744 0.0 0.0001997826364914 0.0015053147011855 0.0 1422 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +917005 VWF SELP VWF-SELP T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.0072547362792554 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0036144684673052 0.0222228052993653 0.0 7.938563872013635e-05 0.0131454254887199 0.0 10879 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +917161 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Pericytes B Cells -> Pericytes 0.0072524203038605 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0003083910058032 0.1341680150528327 0.0 0.0009633911368015 0.0239898116676265 0.0 1211 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +917209 C1QB LRP1 C1QB-LRP1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0072519789563854 0.7753420160918723 0.2550748532138862 0.2461374514707439 0.0111808254589153 0.0267255153180908 0.0 0.0004256155055002 0.0264772477424196 0.0 1909 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +917341 C3 LRP1 C3-LRP1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0072504021993807 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.005043231651446 0.0104714078116759 0.0 0.0002744739249771 0.02700940979803 0.0 1093 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +917376 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0072498845571831 0.6213271600240247 0.8818704453527788 0.6198216015396206 0.0083518627398662 0.0051192928876727 0.0 0.0003470095937946 0.0653747750908698 0.0 1633 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +917588 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0072473954281434 0.6659645551150886 0.8581827408615759 0.7917001487310438 0.0081474500750471 0.003930762149527 0.0 0.0 0.0 0.0 2152 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +917795 COL4A2 CD93 COL4A2-CD93 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0072449616981576 0.9188764516910942 0.6587114738285964 0.6198216015396206 0.0090193130488293 0.0042738820064046 0.0 0.0002215657311669 0.0188497684983825 0.0 1354 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +917919 VEGFC FLT1 VEGFC-FLT1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0072433501655693 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0012459853895406 0.0521374123931907 0.0 0.0001223391240518 0.0217651379365544 0.0 4087 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +917939 C3 LRP1 C3-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.007243030822391 0.7796725988275006 0.6207977546603366 0.6198216015396206 0.000819605673545 0.0587195251380622 0.0 4.3327556325823225e-05 0.010456784803922 0.0 1154 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +917961 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0072427236539717 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0141923232885854 0.0032187363284526 0.0 0.0003645833333333 0.1060706443985866 0.0 2400 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +918373 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0072376179338747 0.7745997874735252 0.777821334064334 0.8693461273411047 0.0215813276111062 0.001271575589586 0.0 0.0 0.0 0.0 270 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +918399 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Mast Cells Pericytes -> Mast Cells 0.007237172519715 0.9184503888425788 0.8341464445360613 0.8567148457705164 0.1169448695751571 0.0001871866311057 0.0 0.0022222222222222 0.6869901245169604 0.0 225 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +918570 CD48 CD2 CD48-CD2 Mast Cells Pericytes Mast Cells -> Pericytes 0.0072347411352244 0.7719609236370527 0.7763428264267787 0.8567148457705164 0.0112468593062777 0.0024832440877005 0.0 0.0 0.0 0.0 244 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +918662 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.007233705024476 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0048313935743179 0.0155837683010033 0.0 0.0 0.0 0.0 157 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +918698 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0072331797360153 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0113788029360913 0.0032187363284526 0.0 0.0003974141585417 0.0782826787258385 0.0 2359 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +918723 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0072329005909893 0.6582846571368821 0.6587114738285964 0.9161861017439124 0.0084325366891025 0.0042738820064046 0.0 0.0017156862745098 0.1459625047611678 0.0 408 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +918790 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Pericytes B Cells -> Pericytes 0.0072318933014513 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0052742025956585 0.0091569531245039 0.0 0.0007882291119285 0.2063159304950798 0.0 1211 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +918836 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0072313758751506 0.6303642896310324 0.6331674633943454 0.8824495942126559 0.0097699360831605 0.0041555861088636 0.0 0.0001569431656482 0.029818952085733 0.0 11947 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +918990 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0072294219271035 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0033537993821664 0.1112417752963437 0.0 0.0 0.0 0.0 186 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +919094 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0072279523884229 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0799339500711946 0.0004582650848664 0.0 0.0 0.0 0.0 570 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +919125 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0072275967012087 0.633566764858408 0.7760344326192508 1.0 0.0078992851324392 0.0036702914086929 0.0 0.0001021659174499 0.0417839615734547 0.0 19576 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +919291 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0072251847227537 0.785133132759182 0.9015117569158254 0.7827641335561659 0.001039571291679 0.0246995741084876 0.0 0.0001543209876543 0.0078547933450015 0.0 162 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +919301 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0072250287315388 0.4630253981438691 0.6587114738285964 0.2461374514707439 0.0443339118517084 0.0042738820064046 0.0 0.0006802721088435 0.0578743459111336 0.0 147 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +919518 CD48 CD2 CD48-CD2 Endothelial Cells Macrophages Endothelial Cells -> Macrophages 0.0072223716439365 0.7719609236370527 0.7763428264267787 0.8875000050982297 0.0164675938709007 0.0016204239758814 0.0 0.0 0.0 0.0 2585 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +919553 VWF ITGA9 VWF-ITGA9 Mast Cells Macrophages Mast Cells -> Macrophages 0.007221859639373 0.8525936146535493 0.8794572885381431 0.8567148457705164 0.0002103933337194 0.104965956217838 0.0 0.0005509641873278 0.0123484057015126 0.0 165 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +919587 VWF LRP1 VWF-LRP1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0072214476614872 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0025256125075084 0.0203874717835032 0.0 0.0001173553719008 0.0054949033319932 0.0 6875 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +919626 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0072210491354129 0.4619393085577573 0.6331674633943454 0.2461374514707439 0.0835287751665837 0.0023576674662702 0.0 0.0 0.0 0.0 902 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +919647 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0072207021390631 0.7719609236370527 0.8960994285623033 0.6198216015396206 0.0014378253178126 0.0229905310518441 0.0 0.0 0.0 0.0 887 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +919804 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0072186252853013 0.8840293712888387 0.7779918296243433 0.6198216015396206 0.0061698665784747 0.0053794918117879 0.0 0.0002252252252252 0.0243134193774807 0.0 1332 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +919938 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0072168105790875 0.2510234128936706 0.8587566561291643 0.2461374514707439 0.0009262556366009 0.287457858136305 0.0 0.0007680491551459 0.023359077988138 0.0 1736 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +920003 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0072159264931292 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0009692519480124 0.0491709261488903 0.0 0.0044130626654898 0.1991503729165115 0.0 103 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +920079 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0072148137651341 0.6303682835571691 0.4614667734221426 0.8293805866303694 0.0272543760657653 0.0021449819680126 0.0 0.0010871928680147 0.0394563451932211 0.0 219 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +920149 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0072140608521156 0.6249837837987587 0.7746834992804791 0.9318789094584046 0.0435116250366991 0.00071798405859 0.0 0.0001497005988023 0.1133243789136738 0.0 5010 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +920191 MMRN2 CD93 MMRN2-CD93 Mast Cells Macrophages Mast Cells -> Macrophages 0.0072134899470145 0.8571898293845529 0.944024288971064 0.8567148457705164 0.0004196880356983 0.0484215930647349 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +920276 C3 LRP1 C3-LRP1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0072122605628596 0.7796725988275006 0.7346293219749174 0.7204611100467462 0.000819605673545 0.0416128058995347 0.0 0.0 0.0 0.0 85 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +920331 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0072116254803025 0.7487535481622718 0.7754239189773715 1.0 0.0016417770622885 0.0147571931436988 0.0 0.0 0.0 0.0 14 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +920381 CD48 CD2 CD48-CD2 Pericytes Myoepithelial Cells Pericytes -> Myoepithelial Cells 0.007210669081567 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0076331962782219 0.0071918009517169 0.0 0.0004580852038479 0.1119618647069208 0.0 2183 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +920423 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0072100813430938 0.6342079770588467 0.7754072541855492 1.0 0.0028649117803088 0.009971631136135 0.0 0.0 0.0 0.0 4011 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +920477 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0072095025083113 0.4619393085577573 0.8537710813834968 0.7204611100467462 0.1194227711616854 0.0004138063814779 0.0 0.0002310536044362 0.0201891499021947 0.0 1082 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +920574 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0072084448699241 0.6301823358791634 0.6347970925105053 0.8824495942126559 0.000716220684292 0.0554888093272979 0.0 6.892748828232699e-05 0.0112804806581187 0.0 12090 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +920633 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0072078394327925 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0069047442087267 0.0069630688870869 0.0 0.0 0.0 0.0 1562 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +920646 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0072076459692887 0.662063103571249 0.8537710813834968 0.6198216015396206 0.0967042147306326 0.0004138063814779 0.0 0.0 0.0 0.0 130 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +920733 VWF SELP VWF-SELP CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0072065535292268 0.9275752708651288 0.8819126042133903 0.9429656149619918 0.000245041593909 0.0741032966028748 0.0 0.0004661280298321 0.0107509833482311 0.0 3218 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +920789 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.007205912796379 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0151307911035231 0.003263637675389 0.0 0.0004894762604013 0.0493261827049263 0.0 1362 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +920821 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0072054909854016 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0106340017102282 0.0044430418127202 0.0 0.0 0.0 0.0 42 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +920853 C3 LRP1 C3-LRP1 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0072049696279453 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0091898156146168 0.0032275631628407 0.0 0.0001903553299492 0.0176489752674851 0.0 394 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +921107 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0072018211283335 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0131302879503246 0.0267255153180908 0.0 0.0002470355731225 0.01350939954723 0.0 184 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +921264 A2M LRP1 A2M-LRP1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0071999577302437 0.8392912392980421 0.8604147465201248 0.8567148457705164 0.0005164482812395 0.0436001007095475 0.0 0.0015151515151515 0.0434053817762456 0.0 165 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +921363 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0071987178763253 0.940547666092272 0.9003264838243337 0.9429656149619918 0.0001298888146421 0.1341680150528327 0.0 0.0001035840066293 0.0025793893216279 0.0 3218 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +921558 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0071963131367629 0.8498991475190484 0.6207977546603366 0.8693461273411047 0.018166235813628 0.0016667952436519 0.0 0.0 0.0 0.0 270 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +921631 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0071955120592199 0.8349903778527206 0.9078204025796472 0.8567148457705164 0.0014804857410621 0.0144359394371152 0.0 0.0017109500805152 0.1497197314156604 0.0 276 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +921678 C1QB LRP1 C1QB-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0071947675510177 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0161519521398178 0.0028784826949613 0.0 0.0006142506142506 0.0522447021733411 0.0 407 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +921824 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.00719294126385 0.6342079770588467 0.8818120773736414 0.6198216015396206 0.0073929685753755 0.0054043611446182 0.0 0.000290613193839 0.056980818118463 0.0 3441 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +921847 VWF LRP1 VWF-LRP1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0071927091618722 0.6332974881236617 0.6207977546603366 0.8693461273411047 0.0019871862905238 0.0203874717835032 0.0 0.0002373128879152 0.0111116462536771 0.0 1245 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +921907 COL4A2 CD93 COL4A2-CD93 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0071918635095586 0.4630253981438691 0.4630027772793905 0.8767341187813953 0.0047240947268779 0.0155837683010033 0.0 0.0001224489795918 0.0338505278977928 0.0 2450 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +921940 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0071914623350275 0.6160088550075702 0.8628183098412396 0.7917001487310438 0.0009692519480124 0.0339152418223636 0.0 3.483106931382794e-05 0.0026611740861908 0.0 1305 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +922152 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0071887420230789 0.718867305289982 0.7167436199046466 0.8767341187813953 0.0024319941937022 0.0125623889131764 0.0 0.0005408163265306 0.1742120871692047 0.0 2450 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +922342 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0071858874102825 0.785133132759182 0.7167436199046466 0.7204611100467462 0.001039571291679 0.0326667674102811 0.0 0.0054054054054054 0.1080160573444093 0.0 37 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +922356 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.007185668702856 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.0142750905665976 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +922409 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0071850818722603 0.6301823358791634 0.7830372268649692 0.6198216015396206 0.0172764782878141 0.0026038611777234 0.0 0.0025839793281653 0.219890368875332 0.0 129 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +922428 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.007184897559544 0.8023917560710954 0.4600037439857229 0.2461374514707439 0.0085367158000785 0.017738069381683 0.0 0.0004148347752091 0.1034224990887266 0.0 12820 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +922474 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0071842665559524 0.7783550150988336 0.4630027772793905 0.2461374514707439 0.0316800311254893 0.0048929293424311 0.0 0.0 0.0 0.0 383 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +922541 C3 LRP1 C3-LRP1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0071834808976595 0.8911088195487638 0.2550748532138862 0.2461374514707439 0.0091898156146168 0.0267255153180908 0.0 0.0001178627553693 0.0186606767996832 0.0 1909 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +922600 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0071828277710578 0.8498991475190484 0.6207977546603366 0.7917001487310438 0.018166235813628 0.0018097844702233 0.0 0.0003224419604471 0.0355727740722912 0.0 1163 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +922691 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0071817308860039 0.4604235282221027 0.4630027772793905 0.8293805866303694 0.0839650520556947 0.0009242223287825 0.0 0.0 0.0 0.0 219 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +922768 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0071807174257448 0.255669001367946 0.9460955677032749 0.2461374514707439 0.0061207051981986 0.0376195773145198 0.0 0.0025826446280991 0.0939664728164273 0.0 176 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +922818 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0071800815522545 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0009153913192522 0.0501711964086628 0.0 0.000281848928974 0.0067130891667443 0.0 887 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +922902 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0071789816595756 0.6332974881236617 0.6252253442669611 0.8824495942126559 0.0003521782369754 0.1112417752963437 0.0 4.511617414843222e-05 0.0048767672744654 0.0 12090 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +923003 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0071776090845726 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0104129581710415 0.0041555861088636 0.0 0.0008984375 0.1707016973556211 0.0 1280 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +923023 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0071773717665182 0.4630253981438691 0.4630027772793905 0.2461374514707439 0.0443339118517084 0.0058437228618857 0.0 0.0004265828468792 0.1294508522389976 0.0 13362 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +923115 CXCL12 CXCR4 CXCL12-CXCR4 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0071764102263918 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0052742025956585 0.0080072638027924 0.0 0.0006574004507888 0.1587956416352609 0.0 968 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +923165 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0071757993336158 0.6160088550075702 0.6631822525600675 0.8824495942126559 0.0009692519480124 0.0390724515618796 0.0 0.000135225488502 0.0764049885638724 0.0 12101 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +923204 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0071753384081798 0.6160088550075702 0.7447682696221608 0.6198216015396206 0.0149256517769723 0.0032154705418133 0.0 0.0036702428006775 0.3115455887631736 0.0 161 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +923241 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0071749189963144 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0008320501336843 0.0518891167572028 0.0 0.0009067357512953 0.0331056128740483 0.0 193 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +923322 CD48 CD2 CD48-CD2 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0071737788557129 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0112468593062777 0.0038288178384739 0.0 0.0 0.0 0.0 10 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +923359 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0071732493710866 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0526353932596327 0.0006800116997025 0.0 0.0 0.0 0.0 5 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +923420 VWF ITGA9 VWF-ITGA9 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0071725953095625 0.7848266128497919 0.6252253442669611 0.6198216015396206 0.0004024409845247 0.1112417752963437 0.0 0.0 0.0 0.0 1154 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +923442 MMRN2 CD93 MMRN2-CD93 B Cells Pericytes B Cells -> Pericytes 0.0071723475554989 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0003083910058032 0.1281708518900828 0.0 0.0008257638315441 0.0170544391589378 0.0 1211 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +923460 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0071721504976148 0.6342079770588467 0.7480927101953669 0.6198216015396206 0.0073929685753755 0.006260692484444 0.0 0.0 0.0 0.0 361 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +923623 CCN1 CAV1 CCN1-CAV1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0071700818245675 0.8619922139338987 0.943345641464811 0.8875000050982297 0.0054092055025683 0.0034806998160403 0.0 2.2799817601459188e-05 0.0084406680060315 0.0 1462 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +923627 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0071700231574686 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.0012814156885439 0.0350138403862125 0.0 0.0017514749262536 0.0749824517145218 0.0 452 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +923668 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0071693157735737 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0002165306714062 0.1341680150528327 0.0 0.0011061946902654 0.0275458235741109 0.0 452 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +923781 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0071679156818582 0.2486570577556728 0.2531744428854943 1.0 0.0033537993821664 0.0642389143033604 0.0 0.0001783106241458 0.008345625049455 0.0 77495 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +923827 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0071673302461804 0.6303682835571691 0.773263018678637 0.9429656149619918 0.0342558468646473 0.0008609682710384 0.0 0.0005619240278714 0.1685825365073368 0.0 2966 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +923876 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.007166804675307 0.8818165186409654 0.9078204025796472 1.0 0.0026436039558049 0.0064028969591119 0.0 0.0001935251997456 0.0229001619965435 0.0 4019 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +924124 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0071639361291298 0.8718210606749883 0.777821334064334 0.6198216015396206 0.0017670878089588 0.0182001711419816 0.0 0.0 0.0 0.0 1332 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +924206 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0071625565752092 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0016417770622885 0.0267210109213584 0.0 0.0037878787878787 0.3980067486107727 0.0 144 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +924219 VEGFC FLT1 VEGFC-FLT1 Macrophages Macrophages Macrophages -> Macrophages 0.007162445779588 0.8963332422588541 0.8998347793593909 1.0 0.0026007495851186 0.0064362797035136 0.0 0.0002712232167073 0.0982704157270577 0.0 2458 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +924263 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0071618835874608 0.743507317541692 0.777821334064334 0.6198216015396206 0.0020684923107111 0.0182001711419816 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +924349 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0071607873309177 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0039530346951707 0.0104714078116759 0.0 0.0 0.0 0.0 69 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +924597 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0071575701562733 0.6659645551150886 0.6614977577544194 0.9161861017439124 0.0137371823984124 0.0024251058581756 0.0 0.0 0.0 0.0 458 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +924675 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.00715658508801 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0149256517769723 0.0027830389352876 0.0 0.0008699434536755 0.2707878180521709 0.0 209 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +924772 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.007155348322807 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.0037268694422441 0.0104714078116759 0.0 0.0002215133794081 0.0304046540050867 0.0 1881 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +924784 VWF SELP VWF-SELP Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.0071552131508354 0.9011206516381156 0.6572093097629401 0.6198216015396206 0.0008850282134344 0.04130664769978 0.0 2.6138324010664435e-05 0.008871725858513 0.0 1739 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +924814 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0071548548663485 0.6160088550075702 0.4596166826058663 0.2461374514707439 0.0255753403203798 0.0075270071967493 0.0 0.0 0.0 0.0 383 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +924816 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.007154786415058 0.2486570577556728 0.8819126042133903 0.2461374514707439 0.0033537993821664 0.0741032966028748 0.0 0.0001047339757017 0.0024156308067733 0.0 1736 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +924866 MMP2 PECAM1 MMP2-PECAM1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0071541671835869 0.9330801352629944 0.6331674633943454 0.6198216015396206 0.0088108219576754 0.0041555861088636 0.0 0.0005813953488372 0.1104641924242644 0.0 129 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +924879 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0071539419035411 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0012814156885439 0.0587195251380622 0.0 0.000563063063063 0.0396992753007213 0.0 148 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +924936 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0071533387366816 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0069047442087267 0.0042655619249233 0.0 0.0001083658430862 0.023537743873963 0.0 1538 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +925054 VWF ITGA9 VWF-ITGA9 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0071517775243024 0.7848266128497919 0.863034163938375 0.7827641335561659 0.0004024409845247 0.0627102121186242 0.0 0.0079051383399209 0.0635007542478477 0.0 23 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +925091 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0071513079175186 0.9067635403815892 0.930308383061206 0.9429656149619918 0.0411127335336962 0.0004089864655001 0.0 0.0003020265003897 0.5486074761471063 0.0 2566 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +925329 A2M LRP1 A2M-LRP1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0071480795954275 0.7741139100414175 0.6207977546603366 0.8693461273411047 0.0015661096645571 0.0203874717835032 0.0 0.0004629629629629 0.0274509420478375 0.0 360 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +925362 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0071476574828999 0.4629984640915818 0.9078204025796472 0.2461374514707439 0.0201301851612071 0.0064028969591119 0.0 0.0009533558124598 0.1128121948685268 0.0 1384 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +925552 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0071452251100174 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0081474500750471 0.0050968401714881 0.0 0.0 0.0 0.0 3125 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +925572 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0071450112440626 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0351142257737683 0.0014748371602574 0.0 0.0018484288354898 0.0304468615731675 0.0 1082 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +925912 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0071408487358767 0.9067635403815892 0.7167436199046466 0.7204611100467462 0.0106922602624424 0.0026482500471321 0.0 0.0001990445859872 0.1817881269541631 0.0 1884 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +925938 VEGFC FLT1 VEGFC-FLT1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0071405013474175 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0012459853895406 0.026308073552735 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +925968 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.007140175793553 0.6630837220165452 0.7461459456652184 0.6198216015396206 0.0415873844357376 0.0010390313650636 0.0 9.44822373393802e-05 0.0089897053179 0.0 756 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +926083 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0071385285604457 0.4604235282221027 0.4630027772793905 1.0 0.0126864732057784 0.0048929293424311 0.0 8.571981602499702e-05 0.0230666077629217 0.0 77495 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +926172 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.007137506551355 0.255669001367946 0.9255624071030766 0.2461374514707439 0.0002269856810233 1.0 0.0 0.0018427518427518 0.0148294700826778 0.0 74 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +926191 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0071372868609511 0.2490567623945399 0.7754072541855492 0.2461374514707439 0.011649387573427 0.0238720285974944 0.0 0.0 0.0 0.0 316 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +926217 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0071369840022181 0.7840818683779507 0.4641352222874551 0.2461374514707439 0.0032417203409647 0.0455121851821151 0.0 0.0081967213114754 0.6001151064155924 0.0 122 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +926297 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0071358184462985 0.4604235282221027 0.7779918296243433 0.2461374514707439 0.0126864732057784 0.0118035014556376 0.0 0.0 0.0 0.0 316 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +926301 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0071357842361174 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0014431743145616 0.0326667674102811 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +926325 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0071355211020407 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0135527119637784 0.0032275631628407 0.0 0.000494071146245 0.0196894633407257 0.0 253 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +926345 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0071352715872386 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0308750930304183 0.0023576674662702 0.0 0.0001363636363636 0.0423319691202615 0.0 6875 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +926415 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0071343753274026 0.6303642896310324 0.6331674633943454 0.8693461273411047 0.0161193721503025 0.0023576674662702 0.0 0.0003614457831325 0.1733144141181977 0.0 1245 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +926447 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0071340382042477 0.7856500335676843 0.7779918296243433 0.6198216015396206 0.0005542667491398 0.0627790816848129 0.0 0.0029411764705882 0.0644063580287521 0.0 170 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +926484 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0071336894399521 0.7745997874735252 0.8331580262014722 0.6198216015396206 0.0215813276111062 0.001526625481682 0.0 0.0 0.0 0.0 18 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +926607 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0071319645033083 0.8730912658940219 0.6632137581773894 0.6198216015396206 0.0057086106530109 0.0064230792457803 0.0 0.0 0.0 0.0 3 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +926633 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0071316216916551 0.6160088550075702 0.4600037439857229 0.2461374514707439 0.0106340017102282 0.017738069381683 0.0 0.0 0.0 0.0 184 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +926766 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0071300166107081 0.4601010570874773 0.2550748532138862 0.2461374514707439 0.0170183763647696 0.0267255153180908 0.0 0.000390015600624 0.0242626021554201 0.0 12820 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +926929 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0071281025568851 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0291791383241764 0.0021449819680126 0.0 0.0027124773960216 0.0984410840200492 0.0 474 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +926961 VWF ITGA9 VWF-ITGA9 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0071277995214924 0.8525936146535493 0.6252253442669611 0.6198216015396206 0.0002103933337194 0.1886404570313 0.0 0.0 0.0 0.0 30 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +926971 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0071276755697059 0.6332974881236617 0.6207977546603366 0.8824495942126559 0.0131302879503246 0.0028784826949613 0.0 0.0001084334599024 0.0109901194779206 0.0 11947 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +927300 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0071233647348282 0.6249837837987587 0.8341464445360613 0.6198216015396206 0.2159908053119969 0.0001871866311057 0.0 0.0019841269841269 0.2518891687657433 0.0 42 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +927451 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0071214825578763 0.4601010570874773 0.6207977546603366 0.2461374514707439 0.0177188549930425 0.0104714078116759 0.0 0.0003955696202531 0.0395632062854662 0.0 316 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +927502 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0071208299157791 0.7783550150988336 0.8347945881127203 0.6198216015396206 0.0267593032157803 0.0012097093680331 0.0 0.0019867549668874 0.1175868209495093 0.0 151 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +927535 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0071205108771379 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0015847932820241 0.0267210109213584 0.0 0.0011363636363636 0.1194020245832317 0.0 160 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +927576 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.007120030919554 0.7160288858520609 0.6580560501976399 0.6198216015396206 0.0012306151710811 0.0362497659817488 0.0 0.0 0.0 0.0 8 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +927631 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0071192380474011 0.940547666092272 0.8817184225858201 0.9429656149619918 0.0001298888146421 0.1281708518900828 0.0 0.0003884400248601 0.0080224230195283 0.0 3218 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +928067 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0071131856627249 0.7487535481622718 0.7462743270426613 0.7827641335561659 0.0131092554497256 0.0022591041672132 0.0 0.00017283097131 0.0192047309716674 0.0 526 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +928179 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0071114697578724 0.8284725546778968 0.6331674633943454 0.6198216015396206 0.0012187708721425 0.0326412663903893 0.0 0.0016025641025641 0.5458935221180999 0.0 78 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +928217 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0071109145361909 0.9470274865242416 0.7746834992804791 0.6198216015396206 0.0061455194924501 0.0046263543438723 0.0 8.86053517632465e-05 0.0311696948577403 0.0 1881 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +928365 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0071088717098663 0.2542249848376565 0.62431395375366 0.2461374514707439 0.1711385759005754 0.0019304335593669 0.0 0.0005681818181818 0.1402800412169644 0.0 176 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +928500 VWF SELP VWF-SELP Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0071071258891771 0.9011206516381156 0.7760344326192508 0.6198216015396206 0.0008850282134344 0.0335947364052305 0.0 0.0001398210290827 0.0074797412746316 0.0 3576 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +928540 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0071067331822864 0.7487535481622718 0.7754239189773715 0.7827641335561659 0.0015847932820241 0.0178869147172998 0.0 0.0008893280632411 0.1520319124326947 0.0 460 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +928645 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0071053441008324 0.255669001367946 0.9008184599638702 0.2461374514707439 0.0002269856810233 1.0 0.0 0.0018427518427518 0.0148686138132589 0.0 74 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +929183 VWF ITGA9 VWF-ITGA9 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0070986965032236 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0036144684673052 0.0112932915661816 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +929247 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0070979788526833 0.6301823358791634 0.944024288971064 0.6198216015396206 0.000716220684292 0.0484215930647349 0.0 0.0021008403361344 0.0470054946859352 0.0 119 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +929314 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0070971193120951 0.9097736029185508 0.773263018678637 0.6198216015396206 0.0430965463818576 0.0006800116997025 0.0 0.0026455026455026 0.227303115389758 0.0 18 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +929335 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0070968981833313 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0016575843792215 0.0312252462757311 0.0 0.0023775799271549 0.1294923560276837 0.0 1412 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +929378 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0070961813597197 0.255669001367946 0.4600037439857229 1.0 0.0061207051981986 0.017738069381683 0.0 0.0001923877786836 0.0479642162486503 0.0 77495 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +929451 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0070955396814141 0.6332974881236617 0.8794572885381431 0.6198216015396206 0.0003521782369754 0.104965956217838 0.0 0.0 0.0 0.0 119 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +929678 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0070926526483837 0.6342079770588467 0.7746834992804791 1.0 0.0028649117803088 0.0090444648829713 0.0 8.310479514667995e-05 0.0094382864634919 0.0 4011 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +929807 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0070910406698951 0.255669001367946 0.6632137581773894 0.2461374514707439 0.0061207051981986 0.049767778498468 0.0 0.000733137829912 0.2505465346237659 0.0 186 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +929875 MMRN2 CD93 MMRN2-CD93 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0070901605683029 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0002165306714062 0.1281708518900828 0.0 0.0005530973451327 0.0114230784410805 0.0 452 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +930038 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0070881164202249 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0131302879503246 0.0053213839468185 0.0 8.803901889317345e-06 0.0040226781046273 0.0 5163 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +930131 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0070870330202473 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0016417770622885 0.0310998965832685 0.0 0.0021395511309055 0.40376140635189 0.0 1041 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +930242 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0070854049734904 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0085570823799139 0.0042655619249233 0.0 0.0014749262536873 0.3203632750279215 0.0 339 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +930329 CD48 CD2 CD48-CD2 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0070842229505141 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0164675938709007 0.0024251058581756 0.0 0.000332778702163 0.0535079585635043 0.0 3005 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +930525 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0070814377441435 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.011891719340537 0.0267255153180908 0.0 0.0 0.0 0.0 184 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +930542 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0070812580917523 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0015409900107563 0.0292771742399634 0.0 0.0002997601918465 0.0343402864874318 0.0 3336 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +930664 CD48 CD2 CD48-CD2 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0070795971885039 0.6659645551150886 0.6614977577544194 0.9161861017439124 0.0081474500750471 0.0038288178384739 0.0 0.0 0.0 0.0 526 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +930796 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.007078004586945 0.2534163760166434 0.6580560501976399 0.2461374514707439 0.0050543892975134 0.0606066271159369 0.0 0.0 0.0 0.0 2 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +930874 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0070769634803857 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.014525360548861 0.0045642085393754 0.0 0.0003949447077409 0.0452651810202016 0.0 422 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +930923 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0070763101701578 0.6303642896310324 0.9015117569158254 0.6198216015396206 0.0014431743145616 0.0246995741084876 0.0 0.0004854368932038 0.0247082819784514 0.0 103 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +931228 COL4A1 CD93 COL4A1-CD93 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0070719167485415 0.8684504425765611 0.7779918296243433 0.9318789094584046 0.0016831757123532 0.0118035014556376 0.0 0.0001862731050293 0.0176744329793975 0.0 4985 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +931473 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.007068553713104 0.7205550478301406 0.7830372268649692 0.7204611100467462 0.0117842887908422 0.0026038611777234 0.0 0.0001261670451678 0.0107365093054193 0.0 1321 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +931496 CD48 CD2 CD48-CD2 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0070682260947797 0.7719609236370527 0.7763428264267787 0.8567148457705164 0.0164675938709007 0.0014748371602574 0.0 0.0 0.0 0.0 225 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +931530 CD34 SELP CD34-SELP T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.007067790697041 0.633566764858408 0.7478729882108823 0.6198216015396206 0.015517736049123 0.0027351735586246 0.0 0.0013850415512465 0.4050485949697502 0.0 361 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +931646 COL4A2 CD93 COL4A2-CD93 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0070663675064494 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.0047240947268779 0.0118035014556376 0.0 0.0015936254980079 0.1612717843052371 0.0 753 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +931783 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0070644612713557 0.7468485855611411 0.9078204025796472 0.7827641335561659 0.0006689050756654 0.0350138403862125 0.0 0.0007854898600399 0.0336276326996439 0.0 389 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +931949 DLL4 NOTCH4 DLL4-NOTCH4 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0070621425327439 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0002327631000826 0.1615138601457002 0.0 0.0 0.0 0.0 797 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +932042 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0070610059549867 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0055862851962672 0.0063011237754475 0.0 0.0003101187311713 0.0625771883807596 0.0 1881 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +932131 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0070594685476802 0.8730912658940219 0.7757991160529997 0.7204611100467462 0.0057086106530109 0.0044430418127202 0.0 0.0009469696969696 0.0353987820523816 0.0 48 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +932267 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0070576410875778 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.0084812136822336 0.0042655619249233 0.0 0.0008771929824561 0.2221388263780767 0.0 380 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +932420 C3 LRP1 C3-LRP1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0070555735350413 0.7796725988275006 0.6207977546603366 0.6198216015396206 0.000819605673545 0.0501711964086628 0.0 0.0025 0.0719326530803974 0.0 170 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +932544 CD48 CD2 CD48-CD2 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0070540377795937 0.7719609236370527 0.8581827408615759 0.6198216015396206 0.0076331962782219 0.003930762149527 0.0 0.0 0.0 0.0 1996 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +932627 VWF LRP1 VWF-LRP1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0070530115720424 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.00023686843287 0.166956519448744 0.0 0.0006221825694966 0.0046879978417168 0.0 968 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +932743 CD48 CD2 CD48-CD2 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0070514051890377 0.7719609236370527 0.7464347811605867 0.7827641335561659 0.0212837736082081 0.0012805120781881 0.0 0.0027932960893854 0.6780471538372213 0.0 179 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +932867 CD34 SELP CD34-SELP T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0070495551060901 0.633566764858408 0.941479368642921 0.6198216015396206 0.015517736049123 0.0021392900294222 0.0 0.0001453065969195 0.0470039355113278 0.0 3441 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +933074 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0070470281670149 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0106922602624424 0.0032187363284526 0.0 0.0001758087201125 0.0511491956111327 0.0 1422 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +933156 VEGFC FLT1 VEGFC-FLT1 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0070461633818939 0.8963332422588541 0.777821334064334 0.6198216015396206 0.0026007495851186 0.0108892901157311 0.0 0.0 0.0 0.0 1687 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +933207 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0070454306611648 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0015847932820241 0.0310998965832685 0.0 0.0015360983102918 0.2898819313543052 0.0 1302 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +933272 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0070444794212519 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0131302879503246 0.0032275631628407 0.0 0.0 0.0 0.0 103 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +933283 CD48 CD2 CD48-CD2 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0070443826556083 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0076331962782219 0.0062523288579129 0.0 0.0 0.0 0.0 394 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +933412 CD34 SELP CD34-SELP CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0070424717122921 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0298399317533219 0.0022515473538965 0.0 0.0 0.0 0.0 253 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +933507 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0070410480559282 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0053032910137447 0.0069630688870869 0.0 0.0005356186395286 0.0676329614053548 0.0 1867 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +933533 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0070407175221445 0.7840818683779507 0.7754072541855492 0.6198216015396206 0.0032417203409647 0.009971631136135 0.0 0.0 0.0 0.0 170 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +933829 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0070368820463971 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0024319941937022 0.0176963220730796 0.0 0.0016600265604249 0.2198681258973248 0.0 753 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +933988 C3 LRP1 C3-LRP1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.007035045490908 0.8509500867818902 0.6207977546603366 0.6198216015396206 0.0006305085967044 0.0587195251380622 0.0 0.0003205128205128 0.0773533952802951 0.0 78 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +934063 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0070341892834265 0.718867305289982 0.2491073778594529 0.2461374514707439 0.0361307801045652 0.0076066460958003 0.0 0.0003939157566302 0.1662482598140351 0.0 12820 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +934065 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0070341088519947 0.7487535481622718 0.7754239189773715 1.0 0.0131092554497256 0.0015914585039484 0.0 0.0001130991427084 0.0549085147344379 0.0 4019 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +934174 CD34 SELP CD34-SELP Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0070326406103165 0.9303167350027568 0.8819126042133903 0.9429656149619918 0.1314667522621683 0.0001189339410417 0.0 0.0 0.0 0.0 2966 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +934240 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0070318446031191 0.2491449441646273 0.4623922682986163 1.0 0.0108445362943651 0.0096770075292062 0.0 0.000116136524937 0.1053647301550006 0.0 77495 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +934341 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0070304546992886 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.1496557267835524 0.0002517784065132 0.0 0.0 0.0 0.0 4880 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +934549 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0070280593316714 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0255753403203798 0.0015914585039484 0.0 0.0007253384912959 0.3521446607197437 0.0 1880 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +934733 CD34 SELP CD34-SELP Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0070258055157132 0.8532069650852002 0.6572093097629401 0.6198216015396206 0.00083777361258 0.04130664769978 0.0 0.0 0.0 0.0 78 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +934799 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0070249349420132 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.00146889578236 0.0292771742399634 0.0 0.0006298815822625 0.0721587274641425 0.0 1323 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +934825 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0070245952546856 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0065101973396288 0.0045642085393754 0.0 0.0007974481658692 0.0913966812943783 0.0 209 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +934854 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0070241517950697 0.7745997874735252 0.777821334064334 0.9318789094584046 0.016822895653248 0.001271575589586 0.0 3.32667997338656e-05 0.0081470193308051 0.0 5010 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +934897 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0070233476306256 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0035190936623492 0.0104714078116759 0.0 0.0 0.0 0.0 83 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +935058 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.007021050919997 0.724503440376099 0.2562573700401372 0.2461374514707439 1.0 0.0002621208738319 0.0 0.0007246376811594 1.0 0.0 230 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +935083 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.007020740842762 0.6213271600240247 0.62431395375366 0.9592803095773328 0.0093830613230477 0.0034299077593249 0.0 0.0003121516164994 0.032291546534425 0.0 1495 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +935229 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0070186760470685 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0161193721503025 0.0026482500471321 0.0 0.0003895184135977 0.3557485498581753 0.0 1412 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +935363 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0070171462559391 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0083565457974945 0.0036702914086929 0.0 0.0 0.0 0.0 1305 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +935402 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0070164920562872 0.8718210606749883 0.4630488285702799 0.7204611100467462 0.0017670878089588 0.0232163927704059 0.0 8.846426043878272e-05 0.0173094440534828 0.0 1884 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +935437 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0070161314131187 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0016417770622885 0.0292791515533623 0.0 0.0081818181818181 0.1931921557526645 0.0 50 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +935563 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0070144817588674 0.743507317541692 0.4630488285702799 0.7204611100467462 0.0020684923107111 0.0232163927704059 0.0 0.0 0.0 0.0 85 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +935580 EFNB2 PECAM1 EFNB2-PECAM1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0070143249464153 0.7800321422220979 0.6331674633943454 0.9318789094584046 0.0014623066995027 0.0176963220730796 0.0 0.0001003009027081 0.0183354562185092 0.0 4985 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +935620 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0070137906737532 0.7840818683779507 0.7480927101953669 1.0 0.0032417203409647 0.006260692484444 0.0 0.0079505300353356 0.8167834487333641 0.0 1132 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +935644 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0070134778363514 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0016417770622885 0.0292373734098458 0.0 0.0006887052341597 0.1051692139312038 0.0 66 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +935710 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0070127168139631 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0078992851324392 0.0045674276780054 0.0 0.0 0.0 0.0 1280 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +935820 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Macrophages Macrophages -> Macrophages 0.0070113848482955 0.8771078809726828 0.8923034233058523 1.0 0.0080232294691882 0.00189193058407 0.0 0.0001017087062652 0.0383792432224929 0.0 2458 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +935836 VEGFC FLT1 VEGFC-FLT1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.007011167644453 0.7745997874735252 0.777821334064334 0.8693461273411047 0.0012459853895406 0.0182001711419816 0.0 0.0004629629629629 0.0554502173437843 0.0 360 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +935937 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0070098994945854 0.6213271600240247 0.943345641464811 0.6198216015396206 0.0093830613230477 0.0034806998160403 0.0 0.0 0.0 0.0 339 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +935973 CD34 SELP CD34-SELP CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0070094722505636 0.633566764858408 0.6572093097629401 0.9161861017439124 0.0298399317533219 0.0010419094417808 0.0 0.0 0.0 0.0 460 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +936051 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.007008531579429 0.6319926036888139 0.6207977546603366 0.8824495942126559 0.011891719340537 0.0028784826949613 0.0 9.625847493094503e-05 0.0249048949770891 0.0 11947 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +936077 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0070083287973647 0.7783550150988336 0.7461459456652184 0.6198216015396206 0.0316800311254893 0.0010390313650636 0.0 0.0005540166204986 0.0812426588241204 0.0 361 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +936304 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0070052864781745 0.8023917560710954 0.7447682696221608 0.7204611100467462 0.0085367158000785 0.0032154705418133 0.0 0.0080213903743315 0.680889227930375 0.0 51 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +936313 C3 LRP1 C3-LRP1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0070051588066071 0.8509500867818902 0.7346293219749174 0.7204611100467462 0.0006305085967044 0.0416128058995347 0.0 0.0011363636363636 0.106137086264054 0.0 66 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +936394 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0070041727515494 0.7797302331085993 0.885766439573873 0.6198216015396206 0.0200499113739789 0.0013756087909864 0.0 0.0008333333333333 0.3139924345698628 0.0 800 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +936428 A2M LRP1 A2M-LRP1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0070038581601438 0.8392912392980421 0.9078204025796472 0.8567148457705164 0.0005164482812395 0.0350138403862125 0.0 0.000853825136612 0.0498555590704169 0.0 244 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +936453 C1QB LRP1 C1QB-LRP1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0070035026454547 0.8703788833238396 0.9078204025796472 0.6198216015396206 0.0037630364713574 0.0064028969591119 0.0 7.8125e-05 0.0080313519943404 0.0 800 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +936630 VWF ITGA9 VWF-ITGA9 B Cells Pericytes B Cells -> Pericytes 0.0070014906038781 0.6332974881236617 0.9404022517663844 0.6198216015396206 0.00023686843287 0.1347191569099048 0.0 0.0003753471961564 0.0162688506303297 0.0 1211 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +936667 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0070009945357488 0.4636527906642655 0.878254460598671 0.7204611100467462 0.0693389464442948 0.0005788283879716 0.0 0.0 0.0 0.0 11475 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +936808 CD34 SELP CD34-SELP Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0069992826960225 0.7168245244832976 0.4623922682986163 0.8767341187813953 0.0018206581062216 0.0222228052993653 0.0 0.000204081632653 0.0545333622826058 0.0 2450 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +937017 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Endothelial Cells CAFs, DCIS Associated -> Endothelial Cells 0.0069966700989323 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0101610580570933 0.0032875740549697 0.0 0.0003534123929945 0.0570248511210917 0.0 16371 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +937208 C1QB LRP1 C1QB-LRP1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0069942725473856 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0026949121497638 0.0144359394371152 0.0 0.0002332089552238 0.0217930791433595 0.0 536 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +937219 C3 LRP1 C3-LRP1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0069941515237857 0.6319926036888139 0.7769451595923457 0.6198216015396206 0.0691889863216023 0.0005558995075445 0.0 0.0006211180124223 0.139244866445753 0.0 161 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +937321 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0069929113779797 0.8667347161816407 0.6614977577544194 0.7917001487310438 0.0106228227237899 0.0024251058581756 0.0 0.0 0.0 0.0 1867 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +937461 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0069910595553973 0.6213271600240247 0.252518874138558 0.2461374514707439 0.0093830613230477 0.0322196586137726 0.0 0.0018043684710351 0.3157575337417893 0.0 351 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +937474 CD48 CD2 CD48-CD2 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.006990902191388 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0161888123016941 0.0038288178384739 0.0 0.0 0.0 0.0 659 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +937543 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0069899488639751 0.4601010570874773 0.9078204025796472 0.2461374514707439 0.0177188549930425 0.0064028969591119 0.0 9.03179190751445e-05 0.0092847999934571 0.0 1384 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +937583 C3 LRP1 C3-LRP1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0069893610043462 0.9487258305485792 0.6207977546603366 0.6198216015396206 0.0110943464444434 0.0028784826949613 0.0 0.001937984496124 0.5014135158262285 0.0 129 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +937620 VWF SELP VWF-SELP Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0069888280332855 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0003457348439318 0.0741032966028748 0.0 0.0007039420756234 0.0162360318384456 0.0 452 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +937629 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0069887004504737 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0151307911035231 0.0026174949623928 0.0 0.001896813353566 0.6300030405329909 0.0 659 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +937690 COL4A2 CD93 COL4A2-CD93 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0069879319618838 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0033449520260795 0.0155837683010033 0.0 0.0002202104232933 0.0608762857961285 0.0 4087 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +937720 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0069874731005335 0.6630837220165452 0.6587114738285964 0.8824495942126559 0.0415873844357376 0.0007261054236978 0.0 0.0001188495364868 0.015891769043698 0.0 12020 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +937790 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0069865543246137 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0021291294377375 0.0310998965832685 0.0 0.0002840909090909 0.053611686736265 0.0 800 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +937878 A2M LRP1 A2M-LRP1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0069855304377286 0.919551140852988 0.7769451595923457 0.7827641335561659 0.037376181609614 0.0005558995075445 0.0 0.0 0.0 0.0 179 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +937930 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0069849608323599 0.7783550150988336 0.4630027772793905 0.2461374514707439 0.0267593032157803 0.0048929293424311 0.0 0.0007978723404255 0.2579865323732421 0.0 752 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +937932 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0069849333062227 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.000393370777602 0.088850508457521 0.0 0.0 0.0 0.0 103 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +937951 CD34 SELP CD34-SELP CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0069847833201387 0.9303167350027568 0.4623922682986163 0.7204611100467462 0.0016860250240652 0.0222228052993653 0.0 9.123255177447311e-05 0.0243785672096312 0.0 10961 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +937967 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0069845782640876 0.6303642896310324 0.6331674633943454 0.8693461273411047 0.0141923232885854 0.0023576674662702 0.0 0.000135685210312 0.0650614942189525 0.0 737 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +938092 VWF SELP VWF-SELP Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0069829614476576 0.9275752708651288 0.8819126042133903 0.9429656149619918 0.1263644540569636 0.0001189339410417 0.0 0.0001839024091215 1.0 0.0 2966 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +938100 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0069828049107589 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0006856224272495 0.0373075519081129 0.0 0.0019636720667648 0.0370523095252258 0.0 97 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +938200 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0069813487987663 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0008193633790489 0.0397596998227057 0.0 0.0 0.0 0.0 390 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +938297 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0069800252316355 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0673400749834054 0.0004874986369898 0.0 0.0 0.0 0.0 4880 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +938406 CD34 SELP CD34-SELP Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0069785879498528 0.8532069650852002 0.7760344326192508 0.6198216015396206 0.00083777361258 0.0335947364052305 0.0 0.0 0.0 0.0 343 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +938436 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0069782583695245 0.6303682835571691 0.773263018678637 0.9429656149619918 0.0291791383241764 0.0008609682710384 0.0 0.0005938462680473 0.1781595112457895 0.0 2566 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +938561 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0069764037340383 0.831981591331937 0.657421674383923 0.6198216015396206 0.0048935684578858 0.0069492509109592 0.0 0.0 0.0 0.0 144 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +938566 VEGFC FLT1 VEGFC-FLT1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0069763588392546 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.0023125636768155 0.026308073552735 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +938597 VWF LRP1 VWF-LRP1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0069759361069407 0.8525936146535493 0.6207977546603366 0.6198216015396206 0.0002103933337194 0.166956519448744 0.0 0.004498106060606 0.0338921604971916 0.0 144 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +938618 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0069756985778205 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0033973231723341 0.0104714078116759 0.0 0.000805152979066 0.0673002986119375 0.0 69 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +938648 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0069753745107625 0.7800321422220979 0.6331674633943454 0.8693461273411047 0.0113788029360913 0.0023576674662702 0.0 0.0003012048192771 0.0935043494624252 0.0 1245 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +938686 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0069749452612291 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0015847932820241 0.0292791515533623 0.0 0.0024570024570024 0.0580156623881875 0.0 37 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +938795 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0069732617970928 0.4625081978296446 0.8381155706134242 0.7204611100467462 0.0141498126994191 0.0029095741067474 0.0 0.0 0.0 0.0 48 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +938862 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0069723072615098 0.7487535481622718 0.4596166826058663 0.7204611100467462 0.0015847932820241 0.0292373734098458 0.0 0.0 0.0 0.0 85 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +939021 CD48 CD2 CD48-CD2 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0069702778477084 0.9426443637490616 0.6614977577544194 0.7917001487310438 0.0632786830726401 0.0003671083100858 0.0 0.0 0.0 0.0 42 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +939076 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0069695374673819 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.0839650520556947 0.0007261054236978 0.0 0.0001692620176032 0.0226325905101007 0.0 422 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +939106 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0069691648650842 0.2490567623945399 0.6571792026963191 0.2461374514707439 0.011649387573427 0.0244129856070659 0.0 0.0 0.0 0.0 373 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +939135 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0069687903315018 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0012814156885439 0.0501711964086628 0.0 0.0015887658876588 0.0269567635631685 0.0 271 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +939444 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0069647304855587 0.2542249848376565 0.7832252605020791 0.2461374514707439 0.1711385759005754 0.00136079311934 0.0 0.0027777777777777 0.4083359232017682 0.0 84 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +939731 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0069609481452281 0.8560892486218385 0.9015117569158254 0.8567148457705164 0.0006966068981631 0.0246995741084876 0.0 0.001060606060606 0.0539838524438288 0.0 165 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +939862 CD48 CD2 CD48-CD2 Pericytes Pericytes Pericytes -> Pericytes 0.0069592564262689 0.7719609236370527 0.7763428264267787 1.0 0.0076331962782219 0.0024832440877005 0.0 7.993605115907275e-05 0.0204352562788696 0.0 12510 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +939886 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0069588899323679 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0673400749834054 0.0009249287638231 0.0 0.0 0.0 0.0 103 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +940023 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0069571967614384 0.6605327397359113 0.885766439573873 0.6198216015396206 0.0227314494836465 0.0013756087909864 0.0 0.0002237136465324 0.0842932710254665 0.0 1490 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +940179 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.006955046582556 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0007263013575398 0.0501711964086628 0.0 0.0033492822966507 0.0963691046053171 0.0 209 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +940191 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0069548955406649 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0411214967239829 0.00071798405859 0.0 0.0002726281352235 0.2063813661786644 0.0 917 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +940414 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.006952140806057 0.7835752212271604 0.7746834992804791 0.6198216015396206 0.0064863313435223 0.0046263543438723 0.0 0.0004295532646048 0.1511087526479629 0.0 388 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +940436 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.006951851771654 0.7468485855611411 0.6207977546603366 0.6198216015396206 0.0006689050756654 0.0587195251380622 0.0 6.017716156364337e-05 0.0042428457138263 0.0 1154 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +940441 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0069517913377819 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.0024635726452692 0.0118035014556376 0.0 0.0 0.0 0.0 83 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +940463 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0069514593781685 0.9067635403815892 0.8537710813834968 0.8567148457705164 0.0411127335336962 0.0004138063814779 0.0 0.0003333333333333 0.0485255692422545 0.0 225 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +940528 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0069505970213095 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0021291294377375 0.0178869147172998 0.0 0.0002955082742316 0.0505175648088675 0.0 1692 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +940554 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0069501695199962 0.255669001367946 0.8628183098412396 0.2461374514707439 0.0061207051981986 0.0339152418223636 0.0 0.0003527514613989 0.0269510258063787 0.0 902 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +940662 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0069487558053993 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.000895875398841 0.0689186266365139 0.0 0.0 0.0 0.0 77 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +940727 CD48 CD2 CD48-CD2 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0069479356477172 0.7453966474499909 0.4603649459881741 0.7204611100467462 0.006326966401379 0.0071918009517169 0.0 0.0 0.0 0.0 85 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +940778 MMP2 PECAM1 MMP2-PECAM1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.006947232194027 0.9330801352629944 0.7167436199046466 0.7204611100467462 0.0088108219576754 0.0026482500471321 0.0 0.0 0.0 0.0 715 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +940885 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0069458108568243 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0131092554497256 0.0027830389352876 0.0 0.0 0.0 0.0 409 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +941488 COL4A1 CD93 COL4A1-CD93 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0069379116748875 0.8684504425765611 0.7779918296243433 0.909150863993142 0.0168149984327668 0.001079730675535 0.0 9.087604507451837e-05 0.0139881158230646 0.0 1572 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +941659 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0069360694469679 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0081474500750471 0.0071918009517169 0.0 0.0002969121140142 0.072569106489076 0.0 1684 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +941697 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0069355715764637 0.7482742921073442 0.7779918296243433 0.6198216015396206 0.005733874009046 0.0053794918117879 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +941705 VWF ITGA9 VWF-ITGA9 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0069354224811326 0.6332974881236617 0.6252253442669611 0.9318789094584046 0.0036144684673052 0.0083442542366581 0.0 0.0002177463255307 0.0119864784106667 0.0 5010 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +941726 A2M LRP1 A2M-LRP1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0069350994187254 0.7741139100414175 0.6207977546603366 0.9318789094584046 0.0149044683666724 0.0016667952436519 0.0 0.0002495009980039 0.0501017115426573 0.0 5010 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +941729 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0069350757470143 0.4636527906642655 0.4630488285702799 0.8293805866303694 0.014525360548861 0.0043013567716651 0.0 0.0 0.0 0.0 219 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +941802 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0069339985741525 0.8533682807143209 0.8817184225858201 0.6198216015396206 0.0706049302656684 0.0003375370073613 0.0 0.0002576323586242 0.2244835266968249 0.0 1109 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +941860 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0069334151552953 0.2486570577556728 0.863034163938375 0.2461374514707439 0.0033537993821664 0.0627102121186242 0.0 0.0 0.0 0.0 34 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +941879 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.006933182725161 0.4593282471594782 0.7464347811605867 0.7204611100467462 0.0351142257737683 0.0012805120781881 0.0 0.0 0.0 0.0 1321 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +941933 COL4A2 CD93 COL4A2-CD93 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0069321458342736 0.8355319038299565 0.6587114738285964 0.6198216015396206 0.001123788079051 0.0289462771086338 0.0 0.0025641025641025 0.5458935221180999 0.0 78 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +941946 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0069319446394425 0.8721681415062816 0.885766439573873 0.9429656149619918 0.0110717612136884 0.0013756087909864 0.0 0.0 0.0 0.0 2966 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +941969 HSPG2 LRP1 HSPG2-LRP1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0069315611680983 0.7789175740361626 0.6207977546603366 0.8693461273411047 0.0012941512528773 0.0203874717835032 0.0 0.0003858024691358 0.0120521254394569 0.0 360 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +942082 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0069299458228441 0.6303642896310324 0.6331674633943454 0.8824495942126559 0.0097699360831605 0.0032187363284526 0.0 0.0002301434382359 0.0669571551025117 0.0 4671 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +942098 THBS2 CD36 THBS2-CD36 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0069297720933348 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0008527942416386 0.0455125113141721 0.0 0.0001121441970475 0.0255001647968814 0.0 4087 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +942140 CD34 SELP CD34-SELP Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0069292040686327 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.0082993421103349 0.0045674276780054 0.0 0.0015174506828528 0.4635456114075504 0.0 659 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +942338 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0069267261117103 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.011891719340537 0.0032275631628407 0.0 0.0 0.0 0.0 103 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +942379 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0069260472113525 0.7840818683779507 0.7746834992804791 0.6198216015396206 0.0032417203409647 0.0090444648829713 0.0 0.0 0.0 0.0 170 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +942511 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0069240503426035 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0037159398684439 0.0155837683010033 0.0 0.0 0.0 0.0 77 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +942643 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0069225685575764 0.8667347161816407 0.4603649459881741 0.2461374514707439 0.0106228227237899 0.0105486447632276 0.0 0.0017103762827822 0.3176853591001273 0.0 877 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +942658 THBS2 CD36 THBS2-CD36 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0069223949714778 0.6242573126045354 0.6176321640000088 0.909150863993142 0.004981832968137 0.0063011237754475 0.0 0.0002040758880819 0.0411793742488245 0.0 5921 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +942666 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0069223185156894 0.7468485855611411 0.7346293219749174 0.7204611100467462 0.0006689050756654 0.0416128058995347 0.0 0.0004901960784313 0.0161866738993976 0.0 85 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +942680 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0069222082503021 0.8667347161816407 0.7763428264267787 0.6198216015396206 0.0106228227237899 0.0024832440877005 0.0 0.0 0.0 0.0 1803 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +942834 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.006920194034565 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0069047442087267 0.0046263543438723 0.0 0.0001524855138761 0.0831244485344698 0.0 1093 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +942983 COL4A1 CD93 COL4A1-CD93 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0069182095102982 0.7463064942968751 0.6587114738285964 0.6198216015396206 0.0012430446376512 0.0289462771086338 0.0 0.0001856895271106 0.0274437769251171 0.0 1154 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +943028 CXCL12 CXCR4 CXCL12-CXCR4 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.006917520729797 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0052742025956585 0.0064230792457803 0.0 0.0 0.0 0.0 50 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +943045 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0069172792504754 0.6342079770588467 0.6571792026963191 0.9592803095773328 0.0085570823799139 0.0032020139126304 0.0 0.0006688963210702 0.2157637758660777 0.0 1495 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +943097 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0069166579478801 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0021291294377375 0.0292791515533623 0.0 0.0005753739930955 0.0135859462554616 0.0 79 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +943159 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0069159353196389 0.8023917560710954 0.6632137581773894 0.6198216015396206 0.0085367158000785 0.0038860320327025 0.0 0.0002154243860404 0.1218610836629323 0.0 422 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +943213 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0069151938544363 0.6659645551150886 0.4603649459881741 0.2461374514707439 0.0137371823984124 0.0105486447632276 0.0 0.0 0.0 0.0 351 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +943241 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0069148339310021 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0137371823984124 0.0024832440877005 0.0 0.0 0.0 0.0 379 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +943246 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0069148094314839 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0073929685753755 0.0042655619249233 0.0 0.0002659574468085 0.057767633103439 0.0 1880 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +943304 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.006914041993053 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0021291294377375 0.0292373734098458 0.0 0.0003402710826291 0.0519613333958287 0.0 6412 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +943443 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0069118765474706 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0117842887908422 0.003263637675389 0.0 0.0 0.0 0.0 3646 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +943464 THBS2 CD36 THBS2-CD36 Endothelial Cells Myoepithelial Cells Endothelial Cells -> Myoepithelial Cells 0.0069115824751341 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0039472834455595 0.0056518532344078 0.0 0.0002621514927214 0.2172161808945957 0.0 2702 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +943542 MMRN2 CD93 MMRN2-CD93 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0069105368833131 0.8571898293845529 0.7779918296243433 0.6198216015396206 0.0004196880356983 0.0627790816848129 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +943657 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0069087717594988 0.8023917560710954 0.6631822525600675 0.6198216015396206 0.0085367158000785 0.0038621268649178 0.0 0.000275900124155 0.1705389343737433 0.0 659 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +944023 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.0069041815448682 0.633566764858408 0.7760344326192508 0.8693461273411047 0.0078992851324392 0.0032078747392388 0.0 0.0 0.0 0.0 1044 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +944051 CD34 SELP CD34-SELP T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0069038573417202 0.633566764858408 0.4623922682986163 0.2461374514707439 0.015517736049123 0.0096770075292062 0.0 0.0 0.0 0.0 383 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +944056 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.006903815259267 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0411127335336962 0.0007400708115376 0.0 0.0015224358974358 0.3508512759906936 0.0 312 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +944153 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.006902611669049 0.8630183004227985 0.4614667734221426 0.2461374514707439 0.0006856224272495 0.1609352200462838 0.0 0.000124331717021 0.0026119581859449 0.0 383 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +944204 CD34 SELP CD34-SELP T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0069019275030488 0.633566764858408 0.6572093097629401 0.7917001487310438 0.015517736049123 0.002113171886167 0.0 0.0002083333333333 0.0603418099219615 0.0 2400 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +944608 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0068964603308504 0.7475533330314548 0.4642836810638544 0.7204611100467462 0.0029751676683741 0.0144613249009303 0.0 0.0 0.0 0.0 37 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +944966 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0068916407666762 0.2491408586098361 0.956444566971872 0.2461374514707439 0.0001826541344284 1.0 0.0 0.0116666666666666 0.1058982927110409 0.0 15 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +945079 A2M LRP1 A2M-LRP1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0068900953174801 0.919551140852988 0.8755243548400705 0.8567148457705164 0.037376181609614 0.0004150165744076 0.0 0.0015151515151515 0.2203856749311294 0.0 165 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +945293 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0068873079068187 0.6319926036888139 0.8604147465201248 0.6198216015396206 0.0007263013575398 0.0436001007095475 0.0 0.0002427184466019 0.0069391385368045 0.0 103 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +945322 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0068868605997509 0.6160088550075702 0.6631822525600675 0.8824495942126559 0.0106340017102282 0.0027830389352876 0.0 8.319467554076539e-05 0.0258960563103968 0.0 12020 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +945323 VWF ITGA9 VWF-ITGA9 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0068868498378674 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0003457348439318 0.1112417752963437 0.0 0.0 0.0 0.0 148 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +945377 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0068862484271881 0.9184503888425788 0.6580560501976399 0.6198216015396206 0.0004696576149175 0.0606066271159369 0.0 0.0 0.0 0.0 390 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +945595 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0068836057457773 0.7158082793127664 0.7346293219749174 0.8767341187813953 0.0071496754272206 0.0032275631628407 0.0 0.0002084645888151 0.0099230619609331 0.0 2453 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +945643 C1QB LRP1 C1QB-LRP1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0068828990092671 0.7753420160918723 0.9078204025796472 0.8567148457705164 0.0012213774841743 0.0144359394371152 0.0 0.0002264492753623 0.0211613956899288 0.0 276 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +945644 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0068828971625029 0.8840293712888387 0.4630027772793905 0.7204611100467462 0.0061698665784747 0.0058437228618857 0.0 5.307855626326964e-05 0.0161072213619537 0.0 1884 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +945675 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0068825293677578 0.7487535481622718 0.7754239189773715 0.7827641335561659 0.0015847932820241 0.0147571931436988 0.0 0.0316205533596837 0.6332349118465117 0.0 23 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +945767 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0068815118099899 0.7800321422220979 0.7841656220878274 0.6198216015396206 0.0213929720256037 0.001309307002134 0.0 0.0010387811634349 0.1282990409787224 0.0 361 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +945803 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0068810268667185 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0048313935743179 0.0053794918117879 0.0 0.0001094690749863 0.0089092520672369 0.0 1305 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +945996 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0068784202276868 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0104129581710415 0.0032187363284526 0.0 0.0004552758435993 0.1324564172151606 0.0 1867 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +946018 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0068781737529077 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0323110954490285 0.0008609682710384 0.0 0.0016290726817042 0.4887372513270598 0.0 380 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +946059 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0068776662747339 0.4593282471594782 0.4603649459881741 0.2461374514707439 0.0181222899145132 0.0112209532878862 0.0 0.0001024800163968 0.0201354881383473 0.0 4879 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +946061 CCN1 CAV1 CCN1-CAV1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0068776159512793 0.6213271600240247 0.62431395375366 0.9318789094584046 0.0023088899408624 0.0126805820762719 0.0 0.0002808425275827 0.0572148079751583 0.0 4985 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +946110 HSPG2 LRP1 HSPG2-LRP1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0068770871684516 0.9253089325030373 0.9078204025796472 0.8875000050982297 0.0022161183602947 0.0064028969591119 0.0 0.00031349749202 0.0370966848875755 0.0 1462 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +946112 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0068770676359784 0.6249837837987587 0.8923034233058523 0.6198216015396206 0.0161757332769496 0.00189193058407 0.0 0.0002551541130843 0.0962810571962519 0.0 1633 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +946239 CCN1 CAV1 CCN1-CAV1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0068751936154398 0.6213271600240247 0.943345641464811 0.6198216015396206 0.0083518627398662 0.0034806998160403 0.0 0.000289226319595 0.1070738101936494 0.0 922 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +946341 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0068739982558123 0.4619393085577573 0.7841656220878274 0.7204611100467462 0.0308750930304183 0.001309307002134 0.0 0.0049019607843137 0.6054373044878273 0.0 51 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +946365 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0068735791069182 0.8640667164982425 0.2491073778594529 0.2461374514707439 1.0 0.0001990509171164 0.0 0.0 0.0 0.0 33 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +946389 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0068732250855432 0.6332974881236617 0.7478729882108823 0.6198216015396206 0.0131302879503246 0.0027351735586246 0.0 0.0001803751803751 0.0099005243810861 0.0 756 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +946421 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0068728527718645 0.9219165193585238 0.62431395375366 0.6198216015396206 0.0086134406931133 0.0034299077593249 0.0 0.0002444987775061 0.0252929769833909 0.0 409 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +946426 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0068728187051001 0.9275752708651288 0.863034163938375 0.8567148457705164 0.000245041593909 0.0627102121186242 0.0 0.0 0.0 0.0 137 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +946549 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0068713082661541 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0141923232885854 0.0026482500471321 0.0 0.0001564945226917 0.1429270031013639 0.0 1278 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +946725 CD34 SELP CD34-SELP Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.006868856060474 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.0082993421103349 0.0036702914086929 0.0 7.272727272727273e-05 0.0297441029731618 0.0 6875 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +946760 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0068683825159801 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0083898580598364 0.0032875740549697 0.0 0.0010285714285714 0.1659651267028256 0.0 3125 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +946844 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0068670707190807 0.6249837837987587 0.7746834992804791 0.909150863993142 0.00263399584678 0.0090444648829713 0.0 0.0002689907467183 0.037847019272869 0.0 1549 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +946915 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0068662952839158 0.6342079770588467 0.7746834992804791 0.8693461273411047 0.0053032910137447 0.0046263543438723 0.0 0.0 0.0 0.0 575 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +946929 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0068661471393116 0.6593525851613742 0.8331580262014722 0.6198216015396206 0.0201572483258557 0.001526625481682 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +947124 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0068637117268369 0.785133132759182 0.6331674633943454 0.6198216015396206 0.001039571291679 0.0326412663903893 0.0 0.000238301559792 0.0965539294353601 0.0 1154 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +947213 VWF SELP VWF-SELP CAFs, DCIS Associated Myoepithelial Cells CAFs, DCIS Associated -> Myoepithelial Cells 0.0068624456635518 0.7158082793127664 0.4623922682986163 0.8293805866303694 0.0071496754272206 0.0053213839468185 0.0 5.047955577990914e-05 0.023065114345896 0.0 9905 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +947228 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0068622537715359 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0113788029360913 0.0026482500471321 0.0 0.0002213172804532 0.0825847673378987 0.0 1412 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +947274 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0068615392891774 0.6319926036888139 0.7769451595923457 0.6198216015396206 0.0616816618657801 0.0005558995075445 0.0 0.0006993006993006 0.1567721922920716 0.0 143 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +947286 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0068614099185454 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0083565457974945 0.0032078747392388 0.0 0.0047846889952153 1.0 0.0 209 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +947397 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Endothelial Cells Basal-like Structured DCIS Cells -> Endothelial Cells 0.0068595921163748 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0020251995753771 0.0144359394371152 0.0 0.0004499785084891 0.0397487605525582 0.0 1692 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +947477 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0068583960601013 0.6593525851613742 0.777821334064334 0.7917001487310438 0.0201572483258557 0.001271575589586 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +947608 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0068567157143342 0.6213271600240247 0.252518874138558 0.2461374514707439 0.0083518627398662 0.0322196586137726 0.0 0.000709219858156 0.1241107439455409 0.0 752 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +947666 MMP2 PECAM1 MMP2-PECAM1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0068559554704096 0.9330801352629944 0.6331674633943454 0.6198216015396206 0.0088108219576754 0.0032187363284526 0.0 0.0001107828655834 0.0322307929803681 0.0 1354 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +947691 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0068554914928909 0.6332974881236617 0.941479368642921 0.6198216015396206 0.0131302879503246 0.0021392900294222 0.0 6.729022273063724e-05 0.0120529332618221 0.0 1351 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +947721 CD48 CD2 CD48-CD2 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0068551559217929 0.7719609236370527 0.4603649459881741 0.2461374514707439 0.0112468593062777 0.0105486447632276 0.0 0.0 0.0 0.0 41 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +947756 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0068547056199796 0.4604235282221027 0.4630027772793905 0.2461374514707439 0.0126864732057784 0.0155837683010033 0.0 0.0001756800281088 0.0413959529680968 0.0 4879 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +947798 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0068541907074526 0.893316592628645 0.7154802332407408 0.7204611100467462 0.0007691101630988 0.0292771742399634 0.0 0.0001537830633586 0.0176172640540402 0.0 9754 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +947876 C3 LRP1 C3-LRP1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0068529710835991 0.8509500867818902 0.6207977546603366 0.6198216015396206 0.0006305085967044 0.0501711964086628 0.0 0.002932098765432 0.0843654573165155 0.0 162 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +947902 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0068526490667315 0.6160088550075702 0.8622452992050237 0.7917001487310438 0.0009692519480124 0.0254056950469408 0.0 0.0009056078021595 0.1422986604363019 0.0 1305 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +948114 CD48 CD2 CD48-CD2 Myoepithelial Cells Pericytes Myoepithelial Cells -> Pericytes 0.0068496852059488 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0161888123016941 0.0024832440877005 0.0 0.0 0.0 0.0 1931 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +948135 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0068494008494653 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0014378253178126 0.0226890201466244 0.0 0.0 0.0 0.0 5683 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +948541 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0068436003599539 0.7745997874735252 0.8331580262014722 0.6198216015396206 0.016822895653248 0.001526625481682 0.0 0.001001001001001 0.4707357648534121 0.0 333 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +948550 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0068435133330741 0.7789175740361626 0.7769451595923457 0.6198216015396206 0.0492631209980634 0.0005558995075445 0.0 0.0006459948320413 0.095471155072788 0.0 129 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +948641 A2M LRP1 A2M-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0068424289823839 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.0149044683666724 0.0018097844702233 0.0 0.000514403292181 0.0694092047744143 0.0 81 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +948648 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0068423459040662 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0016171311116606 0.0203874717835032 0.0 0.0004963670158837 0.0232412775426765 0.0 2152 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +948984 VWF LRP1 VWF-LRP1 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0068379631886892 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0019871862905238 0.0144359394371152 0.0 0.0008559485800705 0.0756100447302766 0.0 2164 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +948990 THBS2 CD36 THBS2-CD36 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0068378790872734 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0063387366560491 0.0056518532344078 0.0 0.000130412102243 0.1080582013766358 0.0 1278 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +949232 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.0068344275362241 0.6332974881236617 0.6572093097629401 0.8824495942126559 0.0131302879503246 0.002113171886167 0.0 5.838734162433585e-05 0.0116889111954622 0.0 4671 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +949248 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0068341353360869 0.7296454584598743 0.8818326005152037 0.7204611100467462 0.0051524613572059 0.0042655619249233 0.0 0.000272331154684 0.0689646683199911 0.0 306 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +949252 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0068340748021531 0.6301823358791634 0.6347970925105053 1.0 0.0031934983073077 0.0079745943515326 0.0 0.000133572191841 0.0160050112564426 0.0 21212 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +949805 COL4A1 CD93 COL4A1-CD93 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0068265097093618 0.9102252263107924 0.7779918296243433 0.6198216015396206 0.0042860632265532 0.0053794918117879 0.0 0.0003607503607503 0.0293600352215763 0.0 594 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +949884 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0068253367842979 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0008193633790489 0.0293997450046583 0.0 0.0 0.0 0.0 887 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +949886 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.006825331326762 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0012306151710811 0.0238720285974944 0.0 0.0 0.0 0.0 753 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +949992 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0068236933243561 0.6561647292424944 0.6207977546603366 0.9592803095773328 0.0142750905665976 0.0018097844702233 0.0 0.0008082497212931 0.1090583424850163 0.0 1495 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +950026 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0068232012108291 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0003788349535045 0.12709315903692 0.0 0.0009143442323165 0.0430737903373867 0.0 1302 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +950129 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0068217462824225 0.2534163760166434 0.4638256179742202 0.2461374514707439 0.0050543892975134 0.0689186266365139 0.0 0.0 0.0 0.0 89 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +950198 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0068209692095083 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0049987108499989 0.0518891167572028 0.0 0.0014099037138927 0.0514766584146874 0.0 727 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +950284 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0068197055349997 0.8560892486218385 0.7167436199046466 0.7204611100467462 0.0006966068981631 0.0326667674102811 0.0 0.0015 0.0299744559130736 0.0 50 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +950381 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0068183911092388 0.6249837837987587 0.8341464445360613 0.6198216015396206 0.1661175896787547 0.0001871866311057 0.0 0.0092592592592592 1.0 0.0 18 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +950418 VWF SELP VWF-SELP Mast Cells Pericytes Mast Cells -> Pericytes 0.0068178748164362 0.8525936146535493 0.8819126042133903 0.8567148457705164 0.0002103933337194 0.0741032966028748 0.0 0.0007451564828614 0.0171866191826168 0.0 244 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +950422 THBS2 CD36 THBS2-CD36 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0068178416926743 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0087456089304998 0.0032616151102094 0.0 0.0002110595187842 0.0668420564819763 0.0 2369 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +950695 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0068140620924593 0.8730912658940219 0.4600037439857229 0.2461374514707439 0.0057086106530109 0.017738069381683 0.0 0.0001677289500167 0.0418165212198402 0.0 271 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +950705 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0068139039341926 0.7783550150988336 0.7461459456652184 0.6198216015396206 0.0267593032157803 0.0010390313650636 0.0 0.001863354037267 0.2732478245544176 0.0 161 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +950932 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0068107291463814 0.255669001367946 0.6631822525600675 0.2461374514707439 0.0061207051981986 0.0390724515618796 0.0 0.0 0.0 0.0 186 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +950968 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0068101412653584 0.7941469661104034 0.7426180951053148 0.6198216015396206 0.0526353932596327 0.0005184623914895 0.0 0.0041407867494824 0.4870920603994158 0.0 23 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +951113 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0068081972058646 0.662063103571249 0.7841656220878274 0.6198216015396206 0.0236359933700329 0.001309307002134 0.0 0.0 0.0 0.0 21 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +951217 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0068066740319573 0.8516956437178343 0.6580560501976399 0.6198216015396206 0.000472352586488 0.0606066271159369 0.0 0.0 0.0 0.0 10 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +951255 CD48 CD2 CD48-CD2 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0068061981761577 0.7719609236370527 0.7763428264267787 1.0 0.0112468593062777 0.0014748371602574 0.0 0.0714285714285714 1.0 0.0 14 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +951308 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0068055148459837 0.6342079770588467 0.8818120773736414 0.6198216015396206 0.0053032910137447 0.0054043611446182 0.0 0.0021052631578947 0.4127810424118552 0.0 475 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +951312 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0068054688165294 0.9184503888425788 0.4638256179742202 0.7204611100467462 0.0004696576149175 0.0689186266365139 0.0 3.041085059149104e-05 0.0028599455329041 0.0 10961 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +951343 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Macrophages 11q13 Invasive Tumor Cells -> Macrophages 0.0068050558489226 0.6301823358791634 0.9195415044619336 0.6198216015396206 0.0208904415011529 0.0013235329769289 0.0 0.0 0.0 0.0 1351 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +951362 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0068047553971723 0.831981591331937 0.8381155706134242 1.0 0.0048935684578858 0.0029095741067474 0.0 0.0238095238095238 0.7520461074274154 0.0 14 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +951533 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0068024591031269 0.8630183004227985 0.8445107771175474 0.909150863993142 0.0006856224272495 0.0218093597373452 0.0 0.0004626416840157 0.0250730206723247 0.0 5764 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +951573 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0068019932430804 0.6589792304505506 0.7769451595923457 0.6198216015396206 0.0561415215593491 0.0005558995075445 0.0 0.0002020870076425 0.0298663071094105 0.0 756 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +951749 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0067994487423248 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0015572459193676 0.0203874717835032 0.0 0.0007575757575757 0.0354717938098156 0.0 1305 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +951751 C3 LRP1 C3-LRP1 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0067994320178428 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0064915662046245 0.0032275631628407 0.0 0.0013713080168776 0.1271421256259619 0.0 474 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +951916 CD48 CD2 CD48-CD2 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.00679701148323 0.7453966474499909 0.8581827408615759 0.6198216015396206 0.006326966401379 0.003930762149527 0.0 0.0 0.0 0.0 162 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +952008 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0067956691932684 0.4629984640915818 0.7769451595923457 0.7204611100467462 0.0683610513379333 0.0005558995075445 0.0 0.0013616557734204 0.2012382190259748 0.0 51 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +952014 C3 LRP1 C3-LRP1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0067955818601194 0.6319926036888139 0.8755243548400705 0.6198216015396206 0.0691889863216023 0.0004150165744076 0.0 0.0011589403973509 0.3340410793787279 0.0 151 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +952017 A2M LRP1 A2M-LRP1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0067955347621244 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.0015661096645571 0.0144359394371152 0.0 0.0003037331566158 0.0372638043548489 0.0 1509 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +952069 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0067949176262425 0.831981591331937 0.657421674383923 0.6198216015396206 0.0048935684578858 0.0059327142047454 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +952254 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0067923855641911 0.6593525851613742 0.4630488285702799 0.6198216015396206 0.0120646829101097 0.0043013567716651 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +952429 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0067898939434058 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.000245041593909 0.1112417752963437 0.0 3.19933453841601e-05 0.0034582741714051 0.0 5683 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +952431 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0067898710106915 0.6303642896310324 0.6331674633943454 1.0 0.0104129581710415 0.0023576674662702 0.0 3.70351450756028e-05 0.0177584710352175 0.0 19576 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +952473 A2M LRP1 A2M-LRP1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0067892932587214 0.8392912392980421 0.6207977546603366 0.6198216015396206 0.0005164482812395 0.0587195251380622 0.0 0.0 0.0 0.0 78 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +952495 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0067889712902186 0.6213271600240247 0.252518874138558 0.2461374514707439 0.1339639999453202 0.0018925243453249 0.0 0.000558659217877 0.0309463197011148 0.0 179 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +952595 CD48 CD2 CD48-CD2 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0067877081607003 0.7453966474499909 0.4603649459881741 0.7204611100467462 0.006326966401379 0.0062523288579129 0.0 0.0 0.0 0.0 37 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +952599 C1QB LRP1 C1QB-LRP1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0067876570852295 0.8703788833238396 0.7769451595923457 0.6198216015396206 0.0419710388788557 0.0005558995075445 0.0 0.0015581717451523 0.1965804095262028 0.0 361 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +952678 THBS2 CD36 THBS2-CD36 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0067866574613409 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0087456089304998 0.0031731220372828 0.0 0.0 0.0 0.0 398 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +952731 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0067858439126223 0.6342079770588467 0.7480927101953669 0.6198216015396206 0.0053032910137447 0.006260692484444 0.0 0.0 0.0 0.0 129 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +952818 CD34 SELP CD34-SELP B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0067847018630401 0.633566764858408 0.7760344326192508 0.9318789094584046 0.0006336851232098 0.0335947364052305 0.0 0.0001003009027081 0.0084367829548142 0.0 4985 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +952843 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0067843550895556 0.4619393085577573 0.7841656220878274 0.2461374514707439 0.0835287751665837 0.001309307002134 0.0 0.0 0.0 0.0 84 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +953034 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Mast Cells Pericytes -> Mast Cells 0.0067816585325867 0.6303682835571691 0.773263018678637 0.8567148457705164 0.0342558468646473 0.0006800116997025 0.0 0.0042328042328042 0.3636849846236128 0.0 225 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +953038 C1QB LRP1 C1QB-LRP1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0067815658778635 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0026949121497638 0.0203874717835032 0.0 0.0 0.0 0.0 126 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +953066 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0067811441749004 0.6160088550075702 0.7447682696221608 0.6198216015396206 0.0106340017102282 0.0032154705418133 0.0 0.0002405002405002 0.0204146682095526 0.0 756 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +953129 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0067801249234774 0.6249837837987587 0.7470475610360806 0.6198216015396206 0.0435116250366991 0.0007714919761827 0.0 0.000230840258541 0.0354454858441009 0.0 361 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +953184 VWF ITGA9 VWF-ITGA9 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0067794350702545 0.8525936146535493 0.863034163938375 1.0 0.0002103933337194 0.0627102121186242 0.0 0.0 0.0 0.0 14 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +953211 C3 LRP1 C3-LRP1 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0067791527983216 0.8911088195487638 0.2550748532138862 0.2461374514707439 0.0064915662046245 0.0267255153180908 0.0 0.0001686746987951 0.02670550190888 0.0 2075 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +953223 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0067789716638774 0.4648000335061383 0.7346293219749174 0.2461374514707439 0.0357762282281787 0.0032275631628407 0.0 0.0016850490196078 0.0995123455315694 0.0 272 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +953237 CCN1 CAV1 CCN1-CAV1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0067787875487884 0.6213271600240247 0.62431395375366 0.9318789094584046 0.013905026986541 0.0019304335593669 0.0 0.0001264138389886 0.0312106758369613 0.0 5010 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +953283 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0067781552822449 0.8349903778527206 0.6207977546603366 0.6198216015396206 0.0014804857410621 0.0203874717835032 0.0 0.0023148148148148 0.0723127526367415 0.0 30 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +953316 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0067777096957298 0.6160088550075702 0.6631822525600675 0.9161861017439124 0.0009692519480124 0.0267210109213584 0.0 0.0002977371973005 0.0312843732532485 0.0 458 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +953371 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0067770204048526 0.6332974881236617 0.950463483645931 0.6198216015396206 0.0131302879503246 0.0019776346124415 0.0 9.314456035767513e-05 0.0390784047043437 0.0 4880 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +953412 CCN1 CAV1 CCN1-CAV1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0067766047968386 0.2542249848376565 0.7283139964676212 0.2461374514707439 0.0014656941948563 0.1449812920932466 0.0 0.0011235955056179 0.0920985366722973 0.0 89 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +953443 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0067761156083586 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0081474500750471 0.0062523288579129 0.0 0.0019762845849802 0.0233582409056611 0.0 253 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +953509 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0067752049413164 0.4636527906642655 0.8331580262014722 0.2461374514707439 0.0666348171285698 0.001526625481682 0.0 0.0 0.0 0.0 34 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +953656 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes B Cells Pericytes -> B Cells 0.0067732155703447 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0342558468646473 0.0008542071298387 0.0 0.0009855306186444 0.1820220457279351 0.0 1063 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +953705 VWF ITGA9 VWF-ITGA9 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0067725915761445 0.7158082793127664 0.863034163938375 0.7204611100467462 0.0003457348439318 0.0627102121186242 0.0 0.0018939393939393 0.0152137223718801 0.0 48 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +953716 C3 LRP1 C3-LRP1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0067724346148315 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0042375227960614 0.0064028969591119 0.0 0.00059375 0.1124883313649407 0.0 800 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +953751 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0067719305056638 0.7468485855611411 0.6207977546603366 0.6198216015396206 0.0006689050756654 0.0501711964086628 0.0 0.0002450980392156 0.0041586050809973 0.0 170 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +953797 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.006771294599701 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0008193633790489 0.040323117011325 0.0 0.0 0.0 0.0 1884 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +954014 A2M LRP1 A2M-LRP1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0067682923141258 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.0021905373114471 0.0144359394371152 0.0 0.0010105721393034 0.1239830478339675 0.0 536 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +954033 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0067680258626984 0.2542249848376565 0.8617632615906476 0.2461374514707439 0.1711385759005754 0.0010414441948928 0.0 0.0 0.0 0.0 34 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +954049 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.006767761374839 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.0047694898966413 0.0053794918117879 0.0 0.0 0.0 0.0 1332 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +954060 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0067676412145077 0.6160088550075702 0.7462743270426613 0.6198216015396206 0.0149256517769723 0.0022591041672132 0.0 0.0022586109542631 0.2509736271080016 0.0 161 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +954112 C1QB LRP1 C1QB-LRP1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0067669286189204 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0111808254589153 0.0028784826949613 0.0 0.0 0.0 0.0 398 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +954331 VWF ITGA9 VWF-ITGA9 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0067642905113119 0.9011206516381156 0.6252253442669611 0.6198216015396206 0.0008850282134344 0.0309945332907452 0.0 0.0001016880211511 0.0063431849686691 0.0 3576 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +954456 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0067627031991599 0.6303642896310324 0.6331674633943454 0.8824495942126559 0.0008320501336843 0.0326412663903893 0.0 6.617038875103394e-05 0.0268106136265056 0.0 12090 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +954512 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.006762033907509 0.4636527906642655 0.4630488285702799 0.8293805866303694 0.0023125636768155 0.0232163927704059 0.0 0.0 0.0 0.0 324 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +954516 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.006761994894953 0.7205550478301406 0.9195415044619336 0.7204611100467462 0.0151307911035231 0.0013235329769289 0.0 0.0 0.0 0.0 591 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +954626 A2M LRP1 A2M-LRP1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0067604505931677 0.8392912392980421 0.7346293219749174 0.7204611100467462 0.0005164482812395 0.0416128058995347 0.0 0.0018939393939393 0.1123482516503149 0.0 66 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +954638 VEGFC FLT1 VEGFC-FLT1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.006760360630485 0.8963332422588541 0.4630488285702799 0.2461374514707439 0.0026007495851186 0.0359289752254096 0.0 0.0 0.0 0.0 263 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +954761 CCN1 CAV1 CCN1-CAV1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.00675888126518 0.8749036366850302 0.62431395375366 0.6198216015396206 0.0004337320404416 0.0649213179279442 0.0 0.0 0.0 0.0 144 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +954850 VWF SELP VWF-SELP CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0067575269435847 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0071496754272206 0.0045674276780054 0.0 0.0 0.0 0.0 233 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +954879 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0067570133705096 0.8840293712888387 0.6587114738285964 0.6198216015396206 0.0061698665784747 0.0042738820064046 0.0 0.000210970464135 0.0179483730990224 0.0 1422 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +954931 CD48 CD2 CD48-CD2 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0067562534594789 0.7719609236370527 0.7464347811605867 0.7827641335561659 0.0164675938709007 0.0012805120781881 0.0 0.0 0.0 0.0 394 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +954958 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0067558057814205 0.7856500335676843 0.6347970925105053 0.6198216015396206 0.0005542667491398 0.0554888093272979 0.0 0.0004332755632582 0.0709086713119526 0.0 1154 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +955189 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0067527666125585 0.7840818683779507 0.8818120773736414 0.7827641335561659 0.0032417203409647 0.0054043611446182 0.0 0.0 0.0 0.0 162 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +955262 COL4A2 CD93 COL4A2-CD93 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.006751699824856 0.7783550150988336 0.7779918296243433 0.8693461273411047 0.0033449520260795 0.0053794918117879 0.0 0.0 0.0 0.0 360 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +955389 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages B Cells Macrophages -> B Cells 0.006749715117827 0.8913986641324685 0.6331674633943454 0.6198216015396206 0.0054950348959687 0.0049190726392343 0.0 0.0009892923649906 0.2000444831155329 0.0 1074 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +955465 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0067486320831198 0.6342079770588467 0.4641352222874551 0.2461374514707439 0.0028649117803088 0.0455121851821151 0.0 0.0 0.0 0.0 752 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +955472 THBS2 CD36 THBS2-CD36 Pericytes Basal-like Structured DCIS Cells Pericytes -> Basal-like Structured DCIS Cells 0.0067485354525394 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0087456089304998 0.0030676679668133 0.0 2.0875083500334e-05 0.0136053845023789 0.0 1996 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +955541 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0067475900617047 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0039530346951707 0.0064028969591119 0.0 0.0 0.0 0.0 380 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +955650 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0067460491089638 0.6593525851613742 0.8331580262014722 0.6198216015396206 0.018132161410931 0.001526625481682 0.0 0.0 0.0 0.0 130 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +955667 CCN1 CAV1 CCN1-CAV1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0067458502580134 0.8749036366850302 0.62431395375366 0.6198216015396206 0.0004337320404416 0.0641739251983978 0.0 0.0 0.0 0.0 30 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +955796 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0067440139171656 0.4636527906642655 0.777821334064334 0.6198216015396206 0.0023125636768155 0.0182001711419816 0.0 0.0 0.0 0.0 126 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +955873 VEGFC FLT1 VEGFC-FLT1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.006742953228223 0.8963332422588541 0.7472387841445823 0.7827641335561659 0.0026007495851186 0.0068935067166085 0.0 0.0018621973929236 0.1132328369960645 0.0 179 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +955939 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0067421711012586 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.0026436039558049 0.0104714078116759 0.0 0.0001772107035264 0.0148125059145891 0.0 1881 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +955971 COL4A1 CD93 COL4A1-CD93 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0067416304270763 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.0017253404164066 0.0289462771086338 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +956088 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0067401279901406 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0071496754272206 0.0047273851759697 0.0 0.0 0.0 0.0 135 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +956104 CCN1 CAV1 CCN1-CAV1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0067398625798301 0.8749036366850302 0.62431395375366 0.6198216015396206 0.0004337320404416 0.0638329144736252 0.0 0.0 0.0 0.0 78 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +956201 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0067384336064207 0.6593525851613742 0.777821334064334 0.7917001487310438 0.018132161410931 0.001271575589586 0.0 0.0005452562704471 0.133532934069794 0.0 917 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +956246 CD48 CD2 CD48-CD2 Mast Cells Macrophages Mast Cells -> Macrophages 0.0067379020494753 0.7719609236370527 0.7763428264267787 0.8567148457705164 0.0112468593062777 0.0016204239758814 0.0 0.006060606060606 1.0 0.0 165 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +956248 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.006737864891089 0.9097736029185508 0.7426180951053148 0.6198216015396206 0.0430965463818576 0.0005184623914895 0.0 0.0025839793281653 0.3039605493190153 0.0 129 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +956435 CCN1 CAV1 CCN1-CAV1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0067355290467271 0.8619922139338987 0.252518874138558 0.2461374514707439 0.0054092055025683 0.0322196586137726 0.0 0.0010139416983523 0.1774358924848798 0.0 263 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +956440 COL4A2 CD93 COL4A2-CD93 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0067355156544466 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0316800311254893 0.0007261054236978 0.0 0.0 0.0 0.0 81 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +956501 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0067346793656314 0.7487535481622718 0.7757991160529997 1.0 0.0131092554497256 0.0012252690191386 0.0 0.0001583387997918 0.1270466028050495 0.0 4019 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +956534 C1QB LRP1 C1QB-LRP1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0067342376803208 0.7452691992612583 0.9078204025796472 0.7827641335561659 0.0012199377895337 0.0144359394371152 0.0 0.0002717391304347 0.0253936748279145 0.0 460 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +956672 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0067321253657617 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.0084325366891025 0.0058437228618857 0.0 0.0008830022075055 0.267955894445217 0.0 453 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +956726 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0067313190034837 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0021291294377375 0.0147571931436988 0.0 0.0025252525252525 0.0505708436544089 0.0 18 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +956902 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0067288873626143 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0255753403203798 0.0012252690191386 0.0 0.0010396518375241 0.8341874147781247 0.0 1880 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +956945 VWF LRP1 VWF-LRP1 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0067281103508344 0.9011206516381156 0.9078204025796472 0.8875000050982297 0.0008850282134344 0.0144359394371152 0.0 0.0002036493971977 0.0179893283194052 0.0 2790 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +956956 VWF LRP1 VWF-LRP1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0067279927442409 0.7848266128497919 0.8604147465201248 0.7827641335561659 0.0004024409845247 0.0436001007095475 0.0 0.0006313131313131 0.0120427923453675 0.0 162 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +957034 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0067268278742132 0.8516956437178343 0.4638256179742202 0.7204611100467462 0.000472352586488 0.0689186266365139 0.0 0.0006404098623118 0.06022644185622 0.0 1041 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +957177 CD48 CD2 CD48-CD2 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0067250245855549 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0076331962782219 0.0038288178384739 0.0 0.0 0.0 0.0 398 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +957218 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0067243611941537 0.6626993710110988 0.6207977546603366 0.9161861017439124 0.0135527119637784 0.0018097844702233 0.0 0.0001358695652173 0.014989542118143 0.0 460 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +957437 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0067211210749072 0.7789175740361626 0.2550748532138862 0.2461374514707439 0.0070532058552773 0.0267255153180908 0.0 0.001341746446185 0.080206073956737 0.0 383 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +957670 CCN1 CAV1 CCN1-CAV1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0067181764633664 0.7324582304061453 0.62431395375366 0.6198216015396206 0.0025580826958339 0.0126805820762719 0.0 0.0003541389995573 0.0721471745414947 0.0 753 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +957786 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0067166099664011 0.6582846571368821 0.6587114738285964 0.9592803095773328 0.0084325366891025 0.0026174949623928 0.0 0.0004742547425474 0.0643400750968269 0.0 1476 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +957792 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0067165816479238 0.6249837837987587 0.7470475610360806 0.6198216015396206 0.0411214967239829 0.0007714919761827 0.0 0.0005827505827505 0.0894812614665764 0.0 143 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +957802 CD34 SELP CD34-SELP Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0067164108290471 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.0082993421103349 0.0032078747392388 0.0 0.0 0.0 0.0 1362 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +957944 VWF ITGA9 VWF-ITGA9 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0067144154884468 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0036144684673052 0.0642389143033604 0.0 0.0004747211013529 0.0222187787964655 0.0 383 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +957972 MMP2 PECAM1 MMP2-PECAM1 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.006714000923891 0.9067635403815892 0.2491073778594529 0.2461374514707439 0.0216588811659259 0.0076066460958003 0.0 0.0006155055002619 0.2597680255287586 0.0 1909 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +957989 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0067138045680936 0.6332974881236617 0.4623922682986163 0.2461374514707439 0.0131302879503246 0.0096770075292062 0.0 0.000494071146245 0.1409489703592807 0.0 184 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +958051 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0067130642453389 0.6626993710110988 0.7769451595923457 0.6198216015396206 0.0515877972474039 0.0005558995075445 0.0 8.267195767195767e-05 0.0104299717576365 0.0 756 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +958130 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0067119316902388 0.8630183004227985 0.8445107771175474 0.909150863993142 0.0016575843792215 0.0083242517891534 0.0 0.0002131235875535 0.0249325254138953 0.0 5921 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +958157 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0067116430703111 0.8684504425765611 0.8347945881127203 0.6198216015396206 0.0168149984327668 0.0012097093680331 0.0 0.0 0.0 0.0 151 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +958174 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0067113668899128 0.6213271600240247 0.8818704453527788 0.6198216015396206 0.0052560850129547 0.0051192928876727 0.0 0.0 0.0 0.0 119 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +958670 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0067042167828118 0.250044481781731 0.7154802332407408 0.2461374514707439 0.0070431301838115 0.0292771742399634 0.0 0.0012297601967616 0.1408803390720303 0.0 4879 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +958721 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0067035275205106 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0117842887908422 0.0026174949623928 0.0 0.0 0.0 0.0 233 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +958761 C3 LRP1 C3-LRP1 Pericytes 11q13 Invasive Tumor Cells (Mitotic) Pericytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0067030120691454 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0091898156146168 0.0028784826949613 0.0 0.0001256281407035 0.0325036902219012 0.0 398 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +958976 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0066997237333729 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0007263013575398 0.0350138403862125 0.0 0.0009894459102902 0.086919381401158 0.0 379 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +959052 VWF SELP VWF-SELP CAFs, DCIS Associated Basal-like Structured DCIS Cells CAFs, DCIS Associated -> Basal-like Structured DCIS Cells 0.0066986741104043 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0071496754272206 0.0036702914086929 0.0 0.0 0.0 0.0 1542 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +959059 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0066986210918849 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0003521782369754 0.0741032966028748 0.0 0.0 0.0 0.0 345 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +959072 COL4A1 CD93 COL4A1-CD93 Mast Cells Macrophages Mast Cells -> Macrophages 0.0066985435580916 0.7766289238087107 0.944024288971064 0.8567148457705164 0.0002970267018348 0.0484215930647349 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +959151 THBS2 CD36 THBS2-CD36 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0066975521918972 0.7809827257946271 0.7373999388878224 0.7204611100467462 0.0004779710276932 0.0455125113141721 0.0 3.200204813108039e-05 0.0072768589250701 0.0 1302 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +959395 MMRN2 CD93 MMRN2-CD93 T Lymphocytes CAFs, DCIS Associated T Lymphocytes -> CAFs, DCIS Associated 0.006694367663764 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0031934983073077 0.0155837683010033 0.0 0.0002527805864509 0.0343773492039207 0.0 10879 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +959660 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0066907111497465 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0106922602624424 0.0023576674662702 0.0 0.0001126126126126 0.0539981095037928 0.0 1332 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +959919 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0066870027394986 0.6605327397359113 0.885766439573873 0.6198216015396206 0.0179229861158654 0.0013756087909864 0.0 0.0 0.0 0.0 380 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +960361 CD48 CD2 CD48-CD2 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0066804017129415 0.4593282471594782 0.4603649459881741 0.2461374514707439 0.0161888123016941 0.0105486447632276 0.0 0.0002340093603744 0.0434649079455244 0.0 12820 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +960635 COL4A2 CD93 COL4A2-CD93 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0066764677485256 0.9188764516910942 0.6587114738285964 0.6198216015396206 0.0090193130488293 0.0026174949623928 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +960740 CD34 SELP CD34-SELP CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0066749280134771 0.633566764858408 0.8347297932672282 0.6198216015396206 0.0298399317533219 0.0009042150166242 0.0 0.0038461538461538 0.6159321105940325 0.0 130 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +960938 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0066719262244209 0.8949858186325867 0.4641352222874551 0.2461374514707439 0.001895566065636 0.0455121851821151 0.0 0.0 0.0 0.0 263 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +960995 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0066712355447612 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0208904415011529 0.0109188419829382 0.0 0.0 0.0 0.0 184 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +961190 CCN1 CAV1 CCN1-CAV1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0066689677439811 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0083518627398662 0.0034299077593249 0.0 0.0004784688995215 0.0494967827091239 0.0 209 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +961331 C3 LRP1 C3-LRP1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0066671805640287 0.7148920381722296 0.9078204025796472 0.7204611100467462 0.0029337538459309 0.0064028969591119 0.0 0.0004084967320261 0.0773913528482564 0.0 306 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +961365 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0066667345949623 0.6319926036888139 0.8755243548400705 0.6198216015396206 0.0616816618657801 0.0004150165744076 0.0 0.0024999999999999 0.7205743283741131 0.0 130 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +961413 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0066660184495102 0.718867305289982 0.2491073778594529 0.2461374514707439 1.0 0.0001990509171164 0.0 0.0017391304347826 1.0 0.0 230 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +961444 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0066656269266317 0.7753420160918723 0.9078204025796472 0.9429656149619918 0.0009153913192522 0.0144359394371152 0.0 4.612546125461255e-05 0.0043103654689449 0.0 2710 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +961456 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0066654853756161 0.6303682835571691 0.4614667734221426 0.8767341187813953 0.0002705513462707 0.12709315903692 0.0 0.0009620991253644 0.0453234728727222 0.0 2450 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +961473 CD34 SELP CD34-SELP Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0066652072066972 0.7168245244832976 0.7478729882108823 0.7204611100467462 0.0082993421103349 0.0027351735586246 0.0 0.0 0.0 0.0 51 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +961516 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0066645575835366 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0012306151710811 0.0244129856070659 0.0 0.0 0.0 0.0 3 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +961536 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0066642780519323 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0016417770622885 0.0215025911544899 0.0 0.0034435261707988 0.4136903368541216 0.0 66 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +961562 THBS2 CD36 THBS2-CD36 Endothelial Cells T Lymphocytes Endothelial Cells -> T Lymphocytes 0.0066639106660491 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0039472834455595 0.0063011237754475 0.0 0.000145085237577 0.0292759686228407 0.0 4595 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +961572 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0066636403478422 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.0208904415011529 0.001079730675535 0.0 0.0008771929824561 0.0963485398236101 0.0 570 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +961592 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0066632385798941 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0061207051981986 0.0293031867940321 0.0 0.000183284457478 0.0229381327506764 0.0 1736 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +961664 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0066622731078548 0.6342079770588467 0.6571792026963191 0.9592803095773328 0.000895875398841 0.0244129856070659 0.0 0.0013550135501355 0.0475868773192081 0.0 1476 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +961807 MMP2 PECAM1 MMP2-PECAM1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0066606446580162 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0024819960935566 0.0125623889131764 0.0 0.0002936138977244 0.0945812606520374 0.0 4087 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +961904 C1QB LRP1 C1QB-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0066592827439976 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0161519521398178 0.0018097844702233 0.0 0.0002003205128205 0.0220999659434159 0.0 312 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +961912 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0066591437043788 0.9470274865242416 0.8923034233058523 0.8875000050982297 0.0061455194924501 0.00189193058407 0.0 0.0 0.0 0.0 1424 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +961986 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0066580988717383 0.4630253981438691 0.6587114738285964 0.2461374514707439 0.0443339118517084 0.0026174949623928 0.0 0.0024128686327077 0.3273433770916314 0.0 373 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +962068 CD48 CD2 CD48-CD2 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0066571606932471 0.6659645551150886 0.6614977577544194 1.0 0.0081474500750471 0.0024251058581756 0.0 0.0007551444213705 0.1214207404065173 0.0 5297 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +962119 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0066562989734311 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0007263013575398 0.0416128058995347 0.0 0.0004551820728291 0.0425142950581505 0.0 714 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +962347 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0066531237537438 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0170183763647696 0.0028784826949613 0.0 0.0010432473444613 0.0887327509977421 0.0 659 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +962380 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0066526988412536 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.0198024073017111 0.001079730675535 0.0 0.0023809523809523 0.402655574491757 0.0 42 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +962476 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0066513099383408 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0075637985935472 0.0032275631628407 0.0 0.0004067875406787 0.0223670614865986 0.0 239 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +962562 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0066499359399741 0.6342079770588467 0.4638256179742202 0.2461374514707439 0.0002327631000826 0.5131068416842878 0.0 0.0031595576619273 0.0717763405013646 0.0 211 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +962635 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0066492204104482 0.7789175740361626 0.8755243548400705 0.6198216015396206 0.0492631209980634 0.0004150165744076 0.0 0.0007716049382716 0.1072501072501073 0.0 18 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +962730 CD48 CD2 CD48-CD2 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0066480216753446 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0112468593062777 0.0024251058581756 0.0 0.0 0.0 0.0 144 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +962731 CD34 SELP CD34-SELP Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0066480103205083 0.7168245244832976 0.941479368642921 0.7204611100467462 0.0082993421103349 0.0021392900294222 0.0 0.0 0.0 0.0 591 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +962758 MMRN2 CD93 MMRN2-CD93 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0066476478934281 0.6301823358791634 0.7779918296243433 0.909150863993142 0.0003083910058032 0.0627790816848129 0.0 0.0003227888960619 0.0070684834505409 0.0 1549 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +962768 CD34 SELP CD34-SELP B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0066475183275826 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0006336851232098 0.04130664769978 0.0 0.0 0.0 0.0 797 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +962841 THBS2 CD36 THBS2-CD36 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0066465818400075 0.9197297916541942 0.7763054211764489 0.7827641335561659 0.0087456089304998 0.0017638974017382 0.0 0.0001318565400843 0.0189356859610243 0.0 316 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +963069 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.006643721311564 0.8730912658940219 0.7447682696221608 0.7204611100467462 0.0057086106530109 0.0032154705418133 0.0 0.0010570824524312 0.0897295881768711 0.0 43 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +963176 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0066421581903972 0.7158082793127664 0.2550748532138862 0.2461374514707439 0.0071496754272206 0.0267255153180908 0.0 0.0004958749525856 0.0271174421370511 0.0 5752 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +963189 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0066419920959725 0.255669001367946 0.4596166826058663 0.2461374514707439 0.0061207051981986 0.0484993884807927 0.0 0.0025066844919786 0.0356362305130664 0.0 272 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +963216 VWF ITGA9 VWF-ITGA9 B Cells Macrophages B Cells -> Macrophages 0.0066416687607071 0.6332974881236617 0.8794572885381431 0.6198216015396206 0.00023686843287 0.104965956217838 0.0 0.0 0.0 0.0 1065 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +963235 COL4A1 CD93 COL4A1-CD93 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0066412923752541 0.8684504425765611 0.7779918296243433 0.9318789094584046 0.0126216524880575 0.001079730675535 0.0 2.85143997718848e-05 0.0043890854438837 0.0 5010 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +963281 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0066407001097767 0.6589792304505506 0.6207977546603366 1.0 0.0072827533047186 0.0028784826949613 0.0 0.000805412371134 0.0595526928469343 0.0 1552 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +963753 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0066343459812497 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.002196330917593 0.009971631136135 0.0 0.0 0.0 0.0 2339 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +964069 THBS2 CD36 THBS2-CD36 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0066298012192834 0.6242573126045354 0.6176321640000088 0.909150863993142 0.0008527942416386 0.0284069116891947 0.0 0.0002420916720464 0.0200535137705988 0.0 1549 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +964101 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0066293095254317 0.2485046029682279 0.8604147465201248 0.2461374514707439 0.0036991419150414 0.0436001007095475 0.0 0.0002252252252252 0.0064390204440618 0.0 222 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +964422 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0066251573525155 0.7487535481622718 0.4600037439857229 0.7204611100467462 0.0015847932820241 0.0215025911544899 0.0 0.0053475935828877 0.6424367584087535 0.0 85 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +964600 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0066227243439558 0.255669001367946 0.8622452992050237 0.2461374514707439 0.0061207051981986 0.0254056950469408 0.0 0.0002519653295706 0.0395914531531157 0.0 902 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +964681 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0066214399203764 0.6213271600240247 0.252518874138558 0.2461374514707439 0.1153131738111426 0.0018925243453249 0.0 0.0024015369836695 0.133030528974533 0.0 694 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +964806 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0066197105911106 0.4601010570874773 0.7769451595923457 0.7204611100467462 0.0587727051993296 0.0005558995075445 0.0 4.731264193792581e-05 0.0059690073041432 0.0 1321 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +964845 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0066189866752669 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0009692519480124 0.0293031867940321 0.0 0.0001199328376109 0.015009648871155 0.0 379 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +964914 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0066180810129203 0.6626993710110988 0.9078204025796472 0.6198216015396206 0.0035190936623492 0.0064028969591119 0.0 0.0011061946902654 0.1137182583269443 0.0 339 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +964946 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0066175996073522 0.6301823358791634 0.6347970925105053 0.8824495942126559 0.0208904415011529 0.0011388334136451 0.0 9.70604547975596e-05 0.0129223513097163 0.0 12020 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +965006 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0066167132834963 0.724503440376099 0.7373999388878224 1.0 0.0027791828709671 0.0056518532344078 0.0 4.472071910916327e-05 0.0370551535332071 0.0 22361 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +965221 A2M LRP1 A2M-LRP1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0066135791787306 0.8392912392980421 0.6207977546603366 0.6198216015396206 0.0005164482812395 0.0501711964086628 0.0 0.0020576131687242 0.0553044232394643 0.0 162 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +965261 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0066130078840884 0.7482742921073442 0.4630027772793905 0.7204611100467462 0.005733874009046 0.0058437228618857 0.0 0.0 0.0 0.0 85 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +965266 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0066129449277378 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0323110954490285 0.0006800116997025 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +965309 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0066122958886619 0.7487535481622718 0.4596166826058663 0.2461374514707439 0.0131092554497256 0.0075270071967493 0.0 0.0002134016218523 0.0942027711613438 0.0 1491 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +965348 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0066117895179572 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0061207051981986 0.0279580382843415 0.0 0.000352360817477 0.0494110614753964 0.0 1806 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +965384 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0066113942489095 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.0051524613572059 0.0046263543438723 0.0 0.0002213368747233 0.0778621461187378 0.0 753 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +965549 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0066092372375354 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0075637985935472 0.0028784826949613 0.0 0.0011291779584462 0.083492122220815 0.0 246 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +965574 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0066088791096582 0.6589792304505506 0.8755243548400705 0.6198216015396206 0.0561415215593491 0.0004150165744076 0.0 0.0 0.0 0.0 42 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +965625 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0066081117460041 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.000895875398841 0.0238720285974944 0.0 0.0 0.0 0.0 69 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +965643 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0066078942745579 0.6319926036888139 0.6207977546603366 0.8824495942126559 0.0004094805141934 0.0587195251380622 0.0 4.755996691480564e-05 0.0114782457512696 0.0 12090 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +965697 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.006607251503996 0.8023917560710954 0.7462743270426613 0.7204611100467462 0.0085367158000785 0.0022591041672132 0.0 0.0 0.0 0.0 51 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +965703 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Endothelial Cells CAFs, Invasive Associated -> Endothelial Cells 0.0066071061391672 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0016171311116606 0.0144359394371152 0.0 0.0005054545454545 0.0446492250595107 0.0 3125 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +965897 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0066041909476581 0.2542249848376565 0.252518874138558 0.3990376746076917 0.1711385759005754 0.0018925243453249 0.0 0.0048109965635738 0.2664999215498069 0.0 97 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +965957 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0066032105236502 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.0839650520556947 0.0003375370073613 0.0 0.0004644250417982 0.40466877618137 0.0 1538 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +965987 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0066027605522293 0.6303682835571691 0.773263018678637 0.8567148457705164 0.0291791383241764 0.0006800116997025 0.0 0.0008465608465608 0.0727369969247225 0.0 225 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +965991 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.006602734604776 0.4629984640915818 0.8755243548400705 0.7204611100467462 0.0683610513379333 0.0004150165744076 0.0 0.0036549707602339 0.5080268238162979 0.0 38 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +966197 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0065999641064276 0.250044481781731 0.6587114738285964 0.2461374514707439 0.0070431301838115 0.0289462771086338 0.0 0.0 0.0 0.0 186 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +966215 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0065996974823002 0.6630837220165452 0.6587114738285964 0.9161861017439124 0.0048313935743179 0.0042738820064046 0.0 0.0006238303181534 0.0450864781870815 0.0 458 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +966225 HSPG2 LRP1 HSPG2-LRP1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.006599595784102 0.9253089325030373 0.6207977546603366 0.6198216015396206 0.0022161183602947 0.0104714078116759 0.0 0.0003534364901814 0.0295426856113224 0.0 3576 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +966242 VWF ITGA9 VWF-ITGA9 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0065993286881069 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.00023686843287 0.1112417752963437 0.0 0.0 0.0 0.0 797 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +966258 C3 LRP1 C3-LRP1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0065992248767659 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0013028322726017 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +966324 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0065979274437512 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0006856224272495 0.0265498740402422 0.0 0.0014697236919459 0.0373383150115349 0.0 81 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +966327 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0065978812935089 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0009692519480124 0.0484993884807927 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +966341 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0065976790043109 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0036991419150414 0.0587195251380622 0.0 0.0001344086021505 0.0324385206014141 0.0 186 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +966354 VWF LRP1 VWF-LRP1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0065975528420309 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0036144684673052 0.0064028969591119 0.0 9.066731141199224e-05 0.009452097386276 0.0 1880 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +966376 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0065971842161102 0.6332974881236617 0.6207977546603366 0.8824495942126559 0.0131302879503246 0.0018097844702233 0.0 7.657691725911355e-05 0.0079551464889804 0.0 12020 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +966416 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0065967008770739 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0272543760657653 0.0008609682710384 0.0 0.0006037525543377 0.1811314910639949 0.0 1538 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +966419 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0065966610995765 0.6301823358791634 0.8347945881127203 0.6198216015396206 0.0208904415011529 0.0012097093680331 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +966532 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0065952391312721 0.6342079770588467 0.7754072541855492 0.8693461273411047 0.0002327631000826 0.0826982152707935 0.0 0.0 0.0 0.0 360 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +966554 C1QB LRP1 C1QB-LRP1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0065949499670162 0.8703788833238396 0.8755243548400705 0.6198216015396206 0.0419710388788557 0.0004150165744076 0.0 0.0007507507507507 0.0929242517975332 0.0 333 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +966576 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0065945875682013 0.7160288858520609 0.836885603004631 0.7204611100467462 0.0069047442087267 0.0027591088867233 0.0 0.0526315789473684 0.7756232686980613 0.0 38 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +966581 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0065945403126276 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0291791383241764 0.0008542071298387 0.0 0.0007891732151252 0.145755921057401 0.0 1418 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +966715 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0065929983604543 0.6301823358791634 0.9195415044619336 0.6198216015396206 0.0172764782878141 0.0013235329769289 0.0 0.0003508771929824 0.0946357436953526 0.0 475 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +966912 HSPG2 LRP1 HSPG2-LRP1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0065896950705103 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0012941512528773 0.0144359394371152 0.0 0.0002393049112731 0.0209408021018746 0.0 1509 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +967110 VWF SELP VWF-SELP Basal-like Structured DCIS Cells CAFs, DCIS Associated Basal-like Structured DCIS Cells -> CAFs, DCIS Associated 0.0065870711047994 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0020251995753771 0.0222228052993653 0.0 0.0 0.0 0.0 800 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +967160 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0065864693504582 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0037159398684439 0.0053794918117879 0.0 0.0003610542784932 0.0293847698763543 0.0 1187 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +967203 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.006585829570995 0.6582846571368821 0.8347945881127203 0.6198216015396206 0.0198024073017111 0.0012097093680331 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +967357 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0065835814815658 0.8684504425765611 0.4630027772793905 0.2461374514707439 0.0168149984327668 0.0048929293424311 0.0 0.0001899696048632 0.0511195026477814 0.0 752 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +967466 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0065819326287037 0.8949858186325867 0.7754072541855492 0.6198216015396206 0.001895566065636 0.009971631136135 0.0 0.0 0.0 0.0 1687 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +967470 THBS2 CD36 THBS2-CD36 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0065818724120174 0.8858959974474152 0.7373999388878224 0.7204611100467462 0.0030563796158022 0.0056518532344078 0.0 0.0 0.0 0.0 715 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +967566 MMRN2 CD93 MMRN2-CD93 Macrophages 11q13 Invasive Tumor Cells Macrophages -> 11q13 Invasive Tumor Cells 0.006580502669033 0.893316592628645 0.6587114738285964 0.6198216015396206 0.0007691101630988 0.0289462771086338 0.0 0.0 0.0 0.0 1739 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +967692 MMRN2 CD93 MMRN2-CD93 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0065788277716305 0.6301823358791634 0.7779918296243433 0.909150863993142 0.0015409900107563 0.0118035014556376 0.0 0.000211112987671 0.0161743603581831 0.0 5921 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +967696 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.006578773512451 0.4593282471594782 0.7763428264267787 0.2461374514707439 0.0181222899145132 0.0050968401714881 0.0 0.0005537098560354 0.1409157750343807 0.0 1806 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +967863 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.006576160658794 0.8718210606749883 0.777821334064334 0.6198216015396206 0.0017670878089588 0.0108892901157311 0.0 0.0001878992859827 0.0233162663032064 0.0 887 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +967889 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Macrophages Macrophages -> Macrophages 0.0065757672403087 0.8949858186325867 0.8818120773736414 1.0 0.001895566065636 0.0054043611446182 0.0 0.0 0.0 0.0 2458 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +967983 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0065743638379718 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0083565457974945 0.0053213839468185 0.0 0.0 0.0 0.0 714 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +967987 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0065742814569017 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0070532058552773 0.0032275631628407 0.0 0.0003701106436029 0.0203503959548476 0.0 713 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +967989 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.006574276520866 0.743507317541692 0.777821334064334 0.6198216015396206 0.0020684923107111 0.0108892901157311 0.0 0.0 0.0 0.0 170 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +968034 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0065737421643584 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0014431743145616 0.0176963220730796 0.0 0.0 0.0 0.0 83 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +968080 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0065731814424822 0.6589792304505506 0.9078204025796472 0.6198216015396206 0.0033973231723341 0.0064028969591119 0.0 0.0001827485380116 0.0216249415094239 0.0 380 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +968198 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0065713801737359 0.6589792304505506 0.2550748532138862 0.2461374514707439 0.0072827533047186 0.0267255153180908 0.0 0.0013057929724596 0.0780568698497882 0.0 351 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +968303 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0065697931011659 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0021291294377375 0.0215025911544899 0.0 0.0002906482164124 0.0349172193239941 0.0 6412 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +968355 CCN1 CAV1 CCN1-CAV1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0065691123812335 0.6213271600240247 0.7283139964676212 0.6198216015396206 0.0023088899408624 0.0124087765732037 0.0 0.0005611672278338 0.0276653274333863 0.0 297 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +968379 THBS2 CD36 THBS2-CD36 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0065687972443738 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.004981832968137 0.0056518532344078 0.0 8.852691218130312e-05 0.0733525396738707 0.0 1412 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +968400 C1QB LRP1 C1QB-LRP1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0065685582414027 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0161519521398178 0.0016667952436519 0.0 8.815232722143864e-05 0.0154950550312836 0.0 1418 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +968451 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0065678792968755 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0009692519480124 0.0279580382843415 0.0 0.0007371007371007 0.1033625988701536 0.0 370 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +968565 VWF SELP VWF-SELP Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0065663014610409 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0019871862905238 0.0222228052993653 0.0 0.000272509265315 0.0451246636033648 0.0 3336 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +968611 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0065656837812993 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0015572459193676 0.0144359394371152 0.0 0.0004914004914004 0.0434077630366622 0.0 370 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +968837 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0065626157810575 0.8913986641324685 0.6331674633943454 0.6198216015396206 0.0054950348959687 0.0041555861088636 0.0 0.0 0.0 0.0 129 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +968849 A2M LRP1 A2M-LRP1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.006562458053774 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.0021905373114471 0.0203874717835032 0.0 0.0013227513227513 0.0784312629938214 0.0 126 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +968870 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0065621149147377 0.6303682835571691 0.8891607331132086 0.6198216015396206 0.0003788349535045 0.0606680526002441 0.0 0.0014697236919459 0.0486052004463807 0.0 162 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +969093 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0065589818511543 0.8730912658940219 0.6632137581773894 0.6198216015396206 0.0057086106530109 0.0038860320327025 0.0 0.0 0.0 0.0 8 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +969198 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0065574475047977 0.6301823358791634 0.7779918296243433 0.8693461273411047 0.0172764782878141 0.001079730675535 0.0 0.0 0.0 0.0 270 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +969296 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0065561769116086 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0037243679732516 0.0112209532878862 0.0 0.0 0.0 0.0 77 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +969389 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0065549188234999 0.7205550478301406 0.8347945881127203 0.7204611100467462 0.0151307911035231 0.0012097093680331 0.0 0.0 0.0 0.0 38 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +969435 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0065544143005138 0.2451358214448441 0.4614667734221426 0.2461374514707439 0.1327555461750915 0.0021449819680126 0.0 0.0113795518207282 0.412986083695223 0.0 272 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +969438 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0065543957047762 0.6561647292424944 0.6207977546603366 0.9592803095773328 0.0070489045197697 0.0028784826949613 0.0 0.00073396567299 0.1186413886453279 0.0 1476 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +969497 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0065535042482153 0.743507317541692 0.7472387841445823 1.0 0.0020684923107111 0.0068935067166085 0.0 0.0005889281507656 0.0358103848450451 0.0 1132 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +969531 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0065530343889592 0.8718210606749883 0.8998347793593909 0.8875000050982297 0.0017670878089588 0.0064362797035136 0.0 0.0 0.0 0.0 1424 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +969595 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.006552188025189 0.8730912658940219 0.6631822525600675 0.6198216015396206 0.0057086106530109 0.0038621268649178 0.0 0.0 0.0 0.0 3 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +969604 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0065521157940133 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0025256125075084 0.0112932915661816 0.0 0.0 0.0 0.0 659 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +969746 VWF SELP VWF-SELP CAFs, DCIS Associated Dendritic Cells CAFs, DCIS Associated -> Dendritic Cells 0.0065500058436619 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0071496754272206 0.0032078747392388 0.0 3.74008876477335e-05 0.0062062046561689 0.0 3646 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +969851 COL4A2 CD93 COL4A2-CD93 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0065486591659209 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0267593032157803 0.0007261054236978 0.0 0.0 0.0 0.0 209 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +970028 VEGFC FLT1 VEGFC-FLT1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0065464225484741 0.8317042416754105 0.4630488285702799 0.7204611100467462 0.0005440770361181 0.0521374123931907 0.0 0.0 0.0 0.0 1041 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +970141 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0065447970271333 0.2542249848376565 0.7283139964676212 0.2461374514707439 0.0014656941948563 0.1176565474247238 0.0 0.0017075773745997 0.1172929723799913 0.0 937 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +970147 VWF LRP1 VWF-LRP1 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0065447477122265 0.7848266128497919 0.9078204025796472 0.7827641335561659 0.0004024409845247 0.0350138403862125 0.0 0.0001752745968684 0.0071597569964318 0.0 389 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +970194 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0065441540530592 0.8571898293845529 0.6347970925105053 0.6198216015396206 0.0004196880356983 0.0554888093272979 0.0 0.0 0.0 0.0 78 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +970314 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0065423637587058 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0053032910137447 0.0042655619249233 0.0 0.0001502855425308 0.032642966707083 0.0 1109 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +970376 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.006541585807899 0.8023917560710954 0.6631822525600675 0.6198216015396206 0.0085367158000785 0.0027830389352876 0.0 0.0 0.0 0.0 422 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +970440 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0065406287068845 0.6160088550075702 0.4596166826058663 0.2461374514707439 0.0149256517769723 0.0075270071967493 0.0 0.0004231141199226 0.1867770369701645 0.0 752 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +970611 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0065381274056908 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0073929685753755 0.0032020139126304 0.0 0.0 0.0 0.0 81 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +970809 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0065354363030845 0.9067635403815892 0.7841656220878274 0.7827641335561659 0.0106922602624424 0.001309307002134 0.0 0.0010931558935361 0.1307472181207074 0.0 526 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +970885 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0065344370563187 0.7160288858520609 0.4641352222874551 0.8293805866303694 0.0069047442087267 0.0040904475843412 0.0 0.0 0.0 0.0 219 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +970907 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0065341683981103 0.7800321422220979 0.2491073778594529 0.2461374514707439 0.0213929720256037 0.0076066460958003 0.0 0.0 0.0 0.0 383 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +970954 A2M LRP1 A2M-LRP1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0065335020216892 0.7460047258226694 0.9078204025796472 0.7827641335561659 0.0010163752993685 0.0144359394371152 0.0 0.0006340579710144 0.0777900326878003 0.0 460 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +971008 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0065326959979003 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0070532058552773 0.0028784826949613 0.0 0.0004295532646048 0.0317614361850316 0.0 97 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +971056 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0065319601480982 0.6342079770588467 0.836885603004631 0.6198216015396206 0.0085570823799139 0.0027591088867233 0.0 0.0 0.0 0.0 5 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +971116 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0065310718335001 0.6561647292424944 0.2550748532138862 0.2461374514707439 0.0070489045197697 0.0267255153180908 0.0 0.0 0.0 0.0 19 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +971183 THBS2 CD36 THBS2-CD36 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0065301830035346 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0009736808737186 0.02871400543887 0.0 0.0 0.0 0.0 148 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +971391 VWF ITGA9 VWF-ITGA9 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0065272110795082 0.8525936146535493 0.6252253442669611 0.6198216015396206 0.0002103933337194 0.1112417752963437 0.0 0.0 0.0 0.0 78 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +971466 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0065262941366503 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.002196330917593 0.0090444648829713 0.0 0.0002137665669089 0.0242776616107734 0.0 2339 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +971512 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0065256867480602 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0104129581710415 0.0026482500471321 0.0 0.000230037429819 0.2100940012447177 0.0 6412 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +971628 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0065240190487743 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0031934983073077 0.0076236123034427 0.0 0.0 0.0 0.0 2400 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +971711 CCN1 CAV1 CCN1-CAV1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0065230133689271 0.6213271600240247 0.62431395375366 0.909150863993142 0.0023088899408624 0.009460730808256 0.0 0.0003443081557994 0.0427479342929888 0.0 1549 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +971739 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0065225696267987 0.2486570577556728 0.8604147465201248 0.2461374514707439 0.0033537993821664 0.0436001007095475 0.0 0.0011261261261261 0.0214817376971421 0.0 222 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +971744 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.006522474878661 0.6626993710110988 0.8755243548400705 0.6198216015396206 0.0515877972474039 0.0004150165744076 0.0 0.0 0.0 0.0 42 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +971919 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0065199634243908 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0272543760657653 0.0008542071298387 0.0 0.0020546289581822 0.3794785865654725 0.0 394 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +971938 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0065197527623174 0.8721681415062816 0.9130058539314824 0.8875000050982297 0.0008193633790489 0.0132636308162813 0.0 0.0 0.0 0.0 1424 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +971957 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0065194474477166 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.000895875398841 0.046975263367762 0.0 0.0 0.0 0.0 77 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +972011 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0065187546158155 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.0142750905665976 0.0016667952436519 0.0 0.0009920634920634 0.1992139482767565 0.0 42 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +972032 THBS2 CD36 THBS2-CD36 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0065184908409173 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0009736808737186 0.0284069116891947 0.0 0.0021525215252152 0.1783027878758537 0.0 271 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +972037 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0065184391983411 0.662063103571249 0.930308383061206 0.6198216015396206 0.0491302556793708 0.0004089864655001 0.0 0.0 0.0 0.0 339 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +972350 MMP2 PECAM1 MMP2-PECAM1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0065139474335727 0.8560892486218385 0.6331674633943454 0.6198216015396206 0.0006966068981631 0.0326412663903893 0.0 0.0003205128205128 0.1298639097533864 0.0 78 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +972420 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0065129924126998 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0078992851324392 0.0053213839468185 0.0 0.0001559575795383 0.0610888946747775 0.0 6412 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +972649 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.006509993109512 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0008320501336843 0.0326667674102811 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +972695 MMP2 PECAM1 MMP2-PECAM1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0065092996112524 0.9330801352629944 0.6331674633943454 0.6198216015396206 0.0088108219576754 0.0023576674662702 0.0 4.208754208754209e-05 0.0201811116327306 0.0 594 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +972717 COL4A1 CD93 COL4A1-CD93 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.006509018331238 0.9102252263107924 0.4630027772793905 0.7204611100467462 0.0042860632265532 0.0058437228618857 0.0 0.0002997002997002 0.0730484772306751 0.0 715 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +972814 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0065075302371156 0.6301823358791634 0.6587114738285964 0.8824495942126559 0.000716220684292 0.0289462771086338 0.0 0.0001447477253928 0.0299328516945406 0.0 12090 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +972843 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.006507184996096 0.8721681415062816 0.885766439573873 0.9429656149619918 0.0008193633790489 0.0127192475389894 0.0 0.0 0.0 0.0 3218 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +973068 VWF LRP1 VWF-LRP1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0065041738509273 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0025256125075084 0.0064028969591119 0.0 0.0002142688261023 0.0223375964239172 0.0 1538 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +973094 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0065037187414803 0.9275752708651288 0.8604147465201248 0.8875000050982297 0.000245041593909 0.0436001007095475 0.0 2.394024514811032e-05 0.0004566789232091 0.0 1424 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +973246 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0065014718877842 0.2534163760166434 0.7470475610360806 0.2461374514707439 0.2100740470724093 0.0007714919761827 0.0 0.0029761904761904 0.4569935853471581 0.0 84 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +973309 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0065005892117543 0.8721681415062816 0.7763400818577846 0.6198216015396206 0.0008193633790489 0.0219439768073448 0.0 0.0 0.0 0.0 1332 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +973332 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0065002756756238 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0361307801045652 0.0007400708115376 0.0 0.0005924170616113 0.1365248167985736 0.0 422 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +973346 VWF SELP VWF-SELP CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0065000708360894 0.7158082793127664 0.7478729882108823 0.7204611100467462 0.0071496754272206 0.0027351735586246 0.0 0.00010322758241 0.0056660078971242 0.0 1321 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +973471 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0064981435349573 0.8624864526942296 0.7746834992804791 0.6198216015396206 0.0020100505037262 0.0090444648829713 0.0 0.0 0.0 0.0 162 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +973563 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0064970501990618 0.4636527906642655 0.777821334064334 0.2461374514707439 0.0666348171285698 0.001271575589586 0.0 0.0009469696969696 0.2319123116325779 0.0 176 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +973575 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0064969326259313 0.2534163760166434 0.6580560501976399 0.2461374514707439 0.0050543892975134 0.0362497659817488 0.0 0.0 0.0 0.0 4 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +973873 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0064927171747912 0.8721681415062816 0.4642836810638544 0.2461374514707439 0.0008193633790489 0.0917308979735958 0.0 0.0 0.0 0.0 1491 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +973919 COL4A2 CD93 COL4A2-CD93 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0064920601945797 0.7482742921073442 0.6587114738285964 0.6198216015396206 0.005733874009046 0.0042738820064046 0.0 0.0 0.0 0.0 160 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +973951 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0064916551586209 0.7840818683779507 0.8818326005152037 0.7827641335561659 0.0032417203409647 0.0042655619249233 0.0 0.0 0.0 0.0 527 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +973972 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0064914483953114 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0033537993821664 0.0587195251380622 0.0 0.0001221896383186 0.0127073286060823 0.0 186 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +973977 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0064913637254508 0.6332974881236617 0.863034163938375 0.6198216015396206 0.0003521782369754 0.0627102121186242 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +973979 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Pericytes Mast Cells -> Pericytes 0.0064913067070754 0.7487535481622718 0.7757991160529997 0.8567148457705164 0.0016417770622885 0.0091569531245039 0.0 0.0 0.0 0.0 244 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +974054 THBS2 CD36 THBS2-CD36 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0064903222688206 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0008527942416386 0.02871400543887 0.0 0.0 0.0 0.0 797 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +974271 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0064869077529895 0.6319926036888139 0.6207977546603366 0.8824495942126559 0.011891719340537 0.0018097844702233 0.0 5.6156405990016646e-05 0.0198305125486415 0.0 12020 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +974335 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0064860726530062 0.7205550478301406 0.9195415044619336 0.7204611100467462 0.0117842887908422 0.0013235329769289 0.0 9.9601593625498e-05 0.0268637320250752 0.0 10040 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +974392 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0064852468772873 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0018436902762588 0.0222228052993653 0.0 0.0 0.0 0.0 77 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +974418 VWF LRP1 VWF-LRP1 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.006484950850679 0.6332974881236617 0.6207977546603366 0.909150863993142 0.0019871862905238 0.0104714078116759 0.0 0.000243739540311 0.0204634083385151 0.0 5921 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +974473 VEGFC FLT1 VEGFC-FLT1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0064841283036752 0.7745997874735252 0.777821334064334 0.909150863993142 0.0012459853895406 0.0108892901157311 0.0 0.0001075962986873 0.0133515353201705 0.0 1549 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +974478 THBS2 CD36 THBS2-CD36 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0064840994176179 0.9197297916541942 0.8587566561291643 0.9429656149619918 0.0087456089304998 0.0011409783203169 0.0 5.619240278714318e-05 0.0429373107303821 0.0 2966 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +974513 C1QB LRP1 C1QB-LRP1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0064836745311326 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0012213774841743 0.0203874717835032 0.0 0.0 0.0 0.0 30 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +974551 VWF SELP VWF-SELP CAFs, DCIS Associated Macrophages CAFs, DCIS Associated -> Macrophages 0.0064833000178805 0.7158082793127664 0.941479368642921 0.7204611100467462 0.0071496754272206 0.0021392900294222 0.0 6.33828323071351e-05 0.0113530467985111 0.0 10040 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +974779 CD48 CD2 CD48-CD2 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0064799864646676 0.7453966474499909 0.6614977577544194 0.6198216015396206 0.006326966401379 0.0038288178384739 0.0 0.0 0.0 0.0 30 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +974879 CD48 CD2 CD48-CD2 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.006478547810482 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0161888123016941 0.0024251058581756 0.0 0.0 0.0 0.0 1562 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +974952 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0064775367488494 0.8911088195487638 0.7346293219749174 0.7204611100467462 0.0048525806497539 0.0032275631628407 0.0 0.0008771929824561 0.0813297807647853 0.0 285 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +975133 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0064747344265643 0.8949858186325867 0.7746834992804791 0.6198216015396206 0.001895566065636 0.0090444648829713 0.0 9.879470460383322e-05 0.0112202036173877 0.0 1687 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +975241 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0064732612987973 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0135527119637784 0.0016667952436519 0.0 0.0003407851690294 0.0599018212496189 0.0 917 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +975369 A2M LRP1 A2M-LRP1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0064712894171785 0.7741139100414175 0.6207977546603366 0.9318789094584046 0.0015661096645571 0.0104714078116759 0.0 0.0001003009027081 0.0137671785396754 0.0 4985 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +975412 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0064707934257481 0.6301823358791634 0.4630027772793905 0.2461374514707439 0.0208904415011529 0.0048929293424311 0.0 0.0 0.0 0.0 184 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +975483 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0064696163859017 0.662063103571249 0.6331674633943454 1.0 0.0236359933700329 0.0007400708115376 0.0 0.000203141928494 0.0396513981248193 0.0 1846 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +975516 C3 LRP1 C3-LRP1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0064691639858787 0.9487258305485792 0.6207977546603366 0.6198216015396206 0.0110943464444434 0.0018097844702233 0.0 0.0007751937984496 0.2737441984894298 0.0 129 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +975553 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0064685772131696 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0002750231449378 0.12709315903692 0.0 0.0005663122333206 0.026678370728875 0.0 9754 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +975602 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0064680596819624 0.6301823358791634 0.7779918296243433 0.8693461273411047 0.0031934983073077 0.0053794918117879 0.0 0.0 0.0 0.0 737 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +975676 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0064668620006735 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0415873844357376 0.0009242223287825 0.0 0.0006934812760055 0.1337716893339081 0.0 103 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +975681 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0064668428080783 0.4648000335061383 0.6207977546603366 0.2461374514707439 0.0357762282281787 0.0028784826949613 0.0 0.0023458445040214 0.3791924605537826 0.0 373 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +975826 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.00646485488062 0.7205550478301406 0.2491545808994955 0.2461374514707439 0.0151307911035231 0.0109188419829382 0.0 0.0004030161206448 0.0580154620164042 0.0 12820 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +975843 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0064645543390746 0.662063103571249 0.2491073778594529 0.2461374514707439 0.0236359933700329 0.0076066460958003 0.0 0.0 0.0 0.0 19 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +975909 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0064635620215776 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.000895875398841 0.0446401662952339 0.0 0.0 0.0 0.0 453 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +975915 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0064633481319303 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0172764782878141 0.0109188419829382 0.0 0.0 0.0 0.0 877 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +975938 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0064630621542073 0.2534163760166434 0.7746834992804791 0.2461374514707439 0.2100740470724093 0.00071798405859 0.0 0.0 0.0 0.0 176 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +975977 VWF LRP1 VWF-LRP1 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0064624607495694 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0025256125075084 0.0104714078116759 0.0 8.317391665973551e-05 0.0069829532686803 0.0 1093 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +976036 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0064616175518605 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0097699360831605 0.0023576674662702 0.0 5.674342105263156e-05 0.027208652676944 0.0 30400 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +976144 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0064601685682819 0.6582846571368821 0.4630027772793905 0.2461374514707439 0.0198024073017111 0.0048929293424311 0.0 0.0002849002849002 0.0921205471722118 0.0 351 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +976192 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0064593404556749 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0033537993821664 0.0565946652887153 0.0 0.0006184291898577 0.0228758634034896 0.0 147 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +976281 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0064582175778743 0.8911088195487638 0.2550748532138862 0.2461374514707439 0.0048525806497539 0.0267255153180908 0.0 8.383635144198524e-05 0.0132734302148429 0.0 1491 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +976350 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0064571025579773 0.6332974881236617 0.6207977546603366 0.8693461273411047 0.0020251995753771 0.0104714078116759 0.0 0.0001185770750988 0.0099552625078272 0.0 575 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +976378 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0064567280316861 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0097699360831605 0.0026482500471321 0.0 9.200077474336628e-05 0.0840246341590964 0.0 5163 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +976416 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0064562486711689 0.6342079770588467 0.4641352222874551 0.2461374514707439 0.002196330917593 0.0455121851821151 0.0 0.0 0.0 0.0 155 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +976456 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0064557347761908 0.6303642896310324 0.9015117569158254 0.6198216015396206 0.0008320501336843 0.0246995741084876 0.0 0.0008403361344537 0.0427723200635378 0.0 119 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +976476 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0064554546815007 0.7158082793127664 0.2531744428854943 0.2461374514707439 0.0025256125075084 0.0642389143033604 0.0 0.0006382073464756 0.0298705657220813 0.0 12820 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +976534 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0064545816557034 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0435116250366991 0.0009249287638231 0.0 0.0002337540906965 0.134576370929026 0.0 713 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +976541 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0064545070494112 0.6332974881236617 0.6252253442669611 0.9161861017439124 0.0003521782369754 0.0565946652887153 0.0 0.0002228163992869 0.0082420390203749 0.0 408 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +976576 CD48 CD2 CD48-CD2 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0064539693083747 0.9426443637490616 0.7763428264267787 0.6198216015396206 0.0632786830726401 0.0002517784065132 0.0 0.0 0.0 0.0 800 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +976639 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0064530022992365 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.0047694898966413 0.0058437228618857 0.0 0.0001137397634212 0.0277227501167371 0.0 1884 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +976745 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0064513166429278 0.7840818683779507 0.6571792026963191 0.6198216015396206 0.0032417203409647 0.0069630688870869 0.0 0.0 0.0 0.0 160 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +976941 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0064487522504166 0.2485046029682279 0.9078204025796472 0.2461374514707439 0.0036991419150414 0.0350138403862125 0.0 0.0005040322580645 0.0442774805793533 0.0 1736 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +977082 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0064468320683265 0.8667347161816407 0.7763428264267787 0.6198216015396206 0.0106228227237899 0.0016204239758814 0.0 0.0 0.0 0.0 475 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +977110 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0064465192698002 0.2491408586098361 0.7167436199046466 0.2461374514707439 0.0049987108499989 0.0326667674102811 0.0 0.0004595588235294 0.0091833504635642 0.0 272 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +977136 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0064461570294173 0.6332974881236617 0.6207977546603366 0.8824495942126559 0.0003521782369754 0.0587195251380622 0.0 6.673434092788929e-05 0.0069401563925526 0.0 12090 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +977179 COL4A2 CD93 COL4A2-CD93 Macrophages Mast Cells Macrophages -> Mast Cells 0.0064454800990952 0.9188764516910942 0.8347945881127203 0.8567148457705164 0.0090193130488293 0.0012097093680331 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +977188 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0064453919230437 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0020251995753771 0.0112932915661816 0.0 0.0002130681818181 0.0079832260224932 0.0 1280 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +977560 VWF LRP1 VWF-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0064404225928383 0.7848266128497919 0.6207977546603366 0.6198216015396206 0.0004024409845247 0.0587195251380622 0.0 0.0001083188908145 0.0112648155667436 0.0 1154 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +977595 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0064399641735122 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0137371823984124 0.0016204239758814 0.0 0.0 0.0 0.0 103 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +977606 C1QB LRP1 C1QB-LRP1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0064398014582777 0.7452691992612583 0.6207977546603366 0.6198216015396206 0.0012199377895337 0.0203874717835032 0.0 0.0030864197530864 0.1747852300163099 0.0 162 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +977689 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0064383916381191 0.662063103571249 0.8537710813834968 0.6198216015396206 0.0491302556793708 0.0004138063814779 0.0 0.0125 1.0 0.0 5 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +977713 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0064379441768732 0.718867305289982 0.930308383061206 0.7204611100467462 0.0361307801045652 0.0004089864655001 0.0 4.8764629388816654e-05 0.0885771288934188 0.0 1538 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +977743 CD48 CD2 CD48-CD2 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0064374650076479 0.7453966474499909 0.7763428264267787 0.7827641335561659 0.006326966401379 0.0024832440877005 0.0 0.0 0.0 0.0 389 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +977756 A2M LRP1 A2M-LRP1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0064371248518357 0.8937519114898692 0.2550748532138862 0.2461374514707439 0.3743986430148447 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +978047 C3 LRP1 C3-LRP1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0064334127086462 0.7148920381722296 0.7346293219749174 0.8293805866303694 0.005043231651446 0.0032275631628407 0.0 0.0021689497716894 0.2010962387403254 0.0 219 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +978164 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0064317716107818 0.4601010570874773 0.8755243548400705 0.7204611100467462 0.0587727051993296 0.0004150165744076 0.0 0.0009242144177449 0.114394735114893 0.0 1082 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +978430 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.006427812018405 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0072827533047186 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +978490 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0064269241035961 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0036991419150414 0.0501711964086628 0.0 0.0041609353507565 0.1197228476303727 0.0 727 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +978497 MMP2 PECAM1 MMP2-PECAM1 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0064268096641644 0.9067635403815892 0.930308383061206 0.9429656149619918 0.0216588811659259 0.0004089864655001 0.0 0.000236008091706 0.4286902088858383 0.0 2966 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +978527 CD48 CD2 CD48-CD2 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0064263330441467 0.7719609236370527 0.4603649459881741 0.2461374514707439 0.0076331962782219 0.0105486447632276 0.0 0.0 0.0 0.0 1909 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +978617 VWF ITGA9 VWF-ITGA9 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0064250690068347 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0019871862905238 0.0112932915661816 0.0 0.0003695491500369 0.013846245675869 0.0 246 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +978639 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0064247182475522 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0149256517769723 0.0015914585039484 0.0 0.0008380989942812 0.4068887692191978 0.0 922 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +978804 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Pericytes B Cells -> Pericytes 0.0064223936363495 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0002327631000826 0.0855781119790033 0.0 0.0008257638315441 0.0416101927973117 0.0 1211 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +978807 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0064223540882995 0.8684504425765611 0.7461459456652184 0.6198216015396206 0.0168149984327668 0.0010390313650636 0.0 0.0008873114463176 0.08442505863767 0.0 161 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +978853 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0064216316220376 0.8284725546778968 0.6331674633943454 0.6198216015396206 0.0012187708721425 0.0176963220730796 0.0 0.0012755102040816 0.2331690031869097 0.0 343 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +979078 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0064186700590738 0.6213271600240247 0.62431395375366 1.0 0.0052560850129547 0.0034299077593249 0.0 0.0002347417840375 0.0242836328314715 0.0 1846 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +979175 COL4A1 CD93 COL4A1-CD93 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0064172172780015 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.0002970267018348 0.0627790816848129 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +979293 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0064154692115956 0.743507317541692 0.8998347793593909 0.7827641335561659 0.0020684923107111 0.0064362797035136 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +979336 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0064147038396165 0.2490567623945399 0.896164124004365 0.2461374514707439 0.000126812416921 1.0 0.0 0.0 0.0 0.0 15 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +979378 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0064141268653093 0.6332974881236617 0.6252253442669611 1.0 0.0015572459193676 0.0112932915661816 0.0 0.0001757263355201 0.0065841039360768 0.0 1552 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +979445 VWF LRP1 VWF-LRP1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0064130620196842 0.7848266128497919 0.7346293219749174 0.7204611100467462 0.0004024409845247 0.0416128058995347 0.0 0.0001336898395721 0.0055431044332664 0.0 85 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +979515 CD34 SELP CD34-SELP Macrophages Macrophages Macrophages -> Macrophages 0.0064119205632551 0.8963354148873306 0.941479368642921 1.0 0.0038492365148421 0.0021392900294222 0.0 0.0002034174125305 0.0658016851482827 0.0 2458 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +979529 VEGFC FLT1 VEGFC-FLT1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0064117781467767 0.8317042416754105 0.777821334064334 0.6198216015396206 0.0005440770361181 0.0318483483218543 0.0 0.0019436345966958 0.2459698144825954 0.0 343 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +979584 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0064110044010621 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0024635726452692 0.0155837683010033 0.0 0.0 0.0 0.0 157 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +979609 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Mast Cells B Cells -> Mast Cells 0.0064107227561859 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0052742025956585 0.0044430418127202 0.0 0.0046860356138706 0.175169230774672 0.0 97 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +979728 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0064090892035269 0.7158082793127664 0.950463483645931 0.7204611100467462 0.0071496754272206 0.0019776346124415 0.0 3.961180431768667e-05 0.0166189642664224 0.0 11475 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +979750 VWF ITGA9 VWF-ITGA9 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0064085670365354 0.7848266128497919 0.6252253442669611 0.6198216015396206 0.0004024409845247 0.0565946652887153 0.0 0.0 0.0 0.0 160 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +979869 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0064069541808927 0.2485046029682279 0.7346293219749174 0.2461374514707439 0.0036991419150414 0.0416128058995347 0.0 0.0003461308187397 0.0323288385791573 0.0 13362 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +979942 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0064061235096818 0.4593282471594782 0.8581827408615759 0.2461374514707439 0.0181222899145132 0.003930762149527 0.0 0.0 0.0 0.0 902 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +980009 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0064049663475379 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0006856224272495 0.0222186841038061 0.0 0.0004861111111111 0.0192222940086075 0.0 2400 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +980234 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0064018018858957 0.6301823358791634 0.6347970925105053 0.9161861017439124 0.0024635726452692 0.0076236123034427 0.0 0.0003639010189228 0.0324305414615524 0.0 458 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +980466 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.006398312258186 0.8684504425765611 0.8347945881127203 0.6198216015396206 0.0126216524880575 0.0012097093680331 0.0 0.0006435006435006 0.0355323872243028 0.0 333 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +980495 CCN1 CAV1 CCN1-CAV1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0063980703221875 0.7324582304061453 0.62431395375366 0.6198216015396206 0.0025580826958339 0.009460730808256 0.0 0.0002460024600246 0.0305426892157932 0.0 271 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +980657 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0063958447935024 0.6160088550075702 0.7462743270426613 0.6198216015396206 0.0106340017102282 0.0022591041672132 0.0 0.0002405002405002 0.0267240436272409 0.0 756 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +980800 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0063940893690036 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0411214967239829 0.0009249287638231 0.0 0.0016469038208168 0.9481517042726836 0.0 253 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +980803 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0063940369501427 0.2491449441646273 0.4623922682986163 0.2461374514707439 0.0108445362943651 0.0222228052993653 0.0 0.0 0.0 0.0 4879 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +980878 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.006392793190535 0.255669001367946 0.6631822525600675 0.2461374514707439 0.0061207051981986 0.0267210109213584 0.0 0.0030921459492888 0.3249034682536919 0.0 147 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +980879 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0063927899669548 0.2491408586098361 0.9015117569158254 0.2461374514707439 0.0049987108499989 0.0246995741084876 0.0 0.0004504504504504 0.0229275048989234 0.0 222 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +980985 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0063910975573942 0.6301823358791634 0.8347945881127203 0.6198216015396206 0.0172764782878141 0.0012097093680331 0.0 0.0 0.0 0.0 18 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +981004 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0063908270166376 0.9275752708651288 0.9078204025796472 0.9429656149619918 0.000245041593909 0.0350138403862125 0.0 0.0001624385558506 0.0066354201208903 0.0 3218 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +981018 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.006390669350655 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0131302879503246 0.0016667952436519 0.0 0.0001594896331738 0.0198227130426377 0.0 570 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +981069 COL4A1 CD93 COL4A1-CD93 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0063899725442177 0.9102252263107924 0.6587114738285964 0.6198216015396206 0.0042860632265532 0.0042738820064046 0.0 0.0003165224730955 0.0228762263770495 0.0 1354 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +981188 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0063883843141845 0.6561647292424944 0.7346293219749174 0.6198216015396206 0.0070489045197697 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +981360 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0063861990707977 0.4593282471594782 0.4603649459881741 0.2461374514707439 0.0181222899145132 0.0071918009517169 0.0 0.0001870977398593 0.0457290732403847 0.0 13362 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +981438 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0063850130223259 0.9184503888425788 0.4641352222874551 0.7204611100467462 0.0004696576149175 0.046975263367762 0.0 0.0 0.0 0.0 10961 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +981648 CD34 SELP CD34-SELP Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0063817443275967 0.633566764858408 0.7760344326192508 1.0 0.0042829523358709 0.0032078747392388 0.0 0.00012465719272 0.0285383554604877 0.0 4011 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +981698 C3 LRP1 C3-LRP1 Macrophages B Cells Macrophages -> B Cells 0.00638102961655 0.9487258305485792 0.6207977546603366 0.6198216015396206 0.0110943464444434 0.0016667952436519 0.0 0.0008612662942271 0.1581890083286848 0.0 1074 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +981817 CD48 CD2 CD48-CD2 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0063792894762629 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0161888123016941 0.0016204239758814 0.0 0.0 0.0 0.0 591 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +981846 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.006378824712354 0.633566764858408 0.6572093097629401 0.9161861017439124 0.0083565457974945 0.002113171886167 0.0 0.0032751091703056 0.9486048721356396 0.0 458 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +981927 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0063777554433118 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.00146889578236 0.0118035014556376 0.0 0.0 0.0 0.0 2300 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +981941 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0063775534717553 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0244483651952677 0.00071798405859 0.0 0.0 0.0 0.0 42 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +982046 CD34 SELP CD34-SELP Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0063760544560675 0.633566764858408 0.7760344326192508 0.8693461273411047 0.0042829523358709 0.0036702914086929 0.0 0.0 0.0 0.0 1245 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +982079 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0063756124987256 0.7835752212271604 0.8923034233058523 0.7827641335561659 0.0064863313435223 0.00189193058407 0.0 0.0 0.0 0.0 162 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +982115 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0063750480062236 0.633566764858408 0.7478729882108823 0.6198216015396206 0.0083565457974945 0.0027351735586246 0.0 0.0 0.0 0.0 23 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +982139 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0063746899164038 0.6342079770588467 0.836885603004631 0.6198216015396206 0.0073929685753755 0.0027591088867233 0.0 0.0 0.0 0.0 333 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +982275 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0063727914740083 0.8913986641324685 0.7167436199046466 0.7204611100467462 0.0054950348959687 0.0026482500471321 0.0 8.741258741258741e-05 0.0326180955191924 0.0 715 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +982369 VWF LRP1 VWF-LRP1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0063712757883155 0.7158082793127664 0.8604147465201248 0.7204611100467462 0.0003457348439318 0.0436001007095475 0.0 0.0006069598057728 0.0115782335902049 0.0 337 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +982815 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0063653932892987 0.4619393085577573 0.2491073778594529 0.2461374514707439 0.0308750930304183 0.0076066460958003 0.0 0.000268135725429 0.1117073904589664 0.0 12820 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +982874 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells T Lymphocytes 11q13 Invasive Tumor Cells -> T Lymphocytes 0.0063646502612474 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0034559943126159 0.0063011237754475 0.0 0.0 0.0 0.0 827 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +982883 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0063645077971188 0.6213271600240247 0.943345641464811 0.6198216015396206 0.0052560850129547 0.0034806998160403 0.0 0.0002631578947368 0.097423078616985 0.0 380 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +983065 CXCL12 CXCR4 CXCL12-CXCR4 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.006361766509168 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0052742025956585 0.0038860320327025 0.0 0.0 0.0 0.0 42 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +983109 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0063611086984954 0.6332974881236617 0.6252253442669611 0.9161861017439124 0.0016171311116606 0.0112932915661816 0.0 0.00017283097131 0.0064756206012619 0.0 526 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +983112 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0063610715527052 0.9219165193585238 0.7832252605020791 0.7827641335561659 0.0086134406931133 0.00136079311934 0.0 6.337135614702154e-05 0.0093156484380631 0.0 526 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +983119 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0063609289176987 0.6659645551150886 0.8581827408615759 0.7917001487310438 0.0037243679732516 0.003930762149527 0.0 0.0 0.0 0.0 1187 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +983260 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0063588851094302 0.718867305289982 0.8537710813834968 0.7204611100467462 0.0361307801045652 0.0004138063814779 0.0 0.0013157894736842 0.1915482996404786 0.0 38 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +983280 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0063585997591381 0.633566764858408 0.941479368642921 0.6198216015396206 0.0083565457974945 0.0021392900294222 0.0 0.0 0.0 0.0 103 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +983309 MMP2 PECAM1 MMP2-PECAM1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0063582348774158 0.9330801352629944 0.7841656220878274 0.7827641335561659 0.0088108219576754 0.001309307002134 0.0 0.0004189944134078 0.0501139446671062 0.0 179 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +983411 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0063568357381795 0.7487535481622718 0.7757991160529997 0.7827641335561659 0.0015847932820241 0.0091569531245039 0.0 0.0007010983874737 0.1835097993606622 0.0 389 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +983542 CXCL12 ITGA4 CXCL12-ITGA4 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0063551769598331 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0052742025956585 0.0038621268649178 0.0 0.0 0.0 0.0 50 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +983607 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0063542611097152 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0028649117803088 0.0069630688870869 0.0 0.0 0.0 0.0 2359 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +983645 CD48 CD2 CD48-CD2 Pericytes Macrophages Pericytes -> Macrophages 0.0063536886635204 0.7719609236370527 0.7763428264267787 0.8875000050982297 0.0076331962782219 0.0016204239758814 0.0 0.0 0.0 0.0 2125 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +983718 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0063525615766488 0.7856500335676843 0.7154802332407408 0.7204611100467462 0.0005542667491398 0.0292771742399634 0.0 0.0002560163850486 0.029329031162845 0.0 1302 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +983896 C3 LRP1 C3-LRP1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0063498937509613 0.7796725988275006 0.9078204025796472 0.7827641335561659 0.000819605673545 0.0144359394371152 0.0 0.0001630434782608 0.0278437003215117 0.0 460 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +983931 CD34 SELP CD34-SELP Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0063493774457562 0.7168245244832976 0.4623922682986163 0.2461374514707439 0.0082993421103349 0.0096770075292062 0.0 0.0001560062402496 0.1415364840242984 0.0 12820 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +983949 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0063490457316042 0.8284725546778968 0.7167436199046466 0.7204611100467462 0.0012187708721425 0.0125623889131764 0.0 0.0003001921229586 0.1393743626832282 0.0 1041 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +984066 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0063474480878784 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0316800311254893 0.0009242223287825 0.0 0.0001402524544179 0.026746253613681 0.0 713 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +984069 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0063474024249301 0.6213271600240247 0.252518874138558 0.2461374514707439 0.0052560850129547 0.0322196586137726 0.0 0.0017543859649122 0.3070107876547592 0.0 19 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +984092 COL4A1 CD93 COL4A1-CD93 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0063469736293452 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0016831757123532 0.0155837683010033 0.0 6.990807088678388e-05 0.0164726249515817 0.0 4087 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +984123 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0063464710528323 0.8667347161816407 0.7763428264267787 0.6198216015396206 0.0106228227237899 0.0014748371602574 0.0 0.0 0.0 0.0 18 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +984149 THBS2 CD36 THBS2-CD36 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0063460155365022 0.8858959974474152 0.6176321640000088 0.6198216015396206 0.0030563796158022 0.0063011237754475 0.0 0.0001747762863534 0.0352671654315103 0.0 3576 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +984183 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0063454208820582 0.2534163760166434 0.4638256179742202 0.2461374514707439 0.0050543892975134 0.0446401662952339 0.0 0.0008893632159373 0.1003630771713042 0.0 937 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +984209 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.006345001271923 0.6160088550075702 0.4600037439857229 0.2461374514707439 0.0052742025956585 0.017738069381683 0.0 0.0012925463162429 0.3222448507272999 0.0 211 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +984218 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0063449195422171 0.2486570577556728 0.9078204025796472 0.2461374514707439 0.0033537993821664 0.0350138403862125 0.0 0.0006873167155425 0.028076063221895 0.0 1736 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +984235 VWF SELP VWF-SELP CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0063446160059224 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0016171311116606 0.0222228052993653 0.0 0.0 0.0 0.0 1323 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +984273 THBS2 CD36 THBS2-CD36 T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0063438062118757 0.6242573126045354 0.6176321640000088 0.8693461273411047 0.0063387366560491 0.0030676679668133 0.0 0.0002261420171867 0.1473885886933426 0.0 737 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +984373 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0063423259097529 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0272543760657653 0.0006800116997025 0.0 0.0018796992481203 0.1615048451453543 0.0 38 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +984380 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0063422284481582 0.6303682835571691 0.7426180951053148 0.7827641335561659 0.0342558468646473 0.0005184623914895 0.0 0.0017329716696805 0.2038541929994391 0.0 316 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +984517 CD48 CD2 CD48-CD2 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0063402464541969 0.7719609236370527 0.7464347811605867 0.7827641335561659 0.0112468593062777 0.0012805120781881 0.0 0.0 0.0 0.0 23 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +984566 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0063397100739251 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0137371823984124 0.0014748371602574 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +984649 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0063385764963602 0.6659645551150886 0.4603649459881741 0.2461374514707439 0.0081474500750471 0.0105486447632276 0.0 0.0 0.0 0.0 155 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +984672 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Pericytes CAFs, Invasive Associated -> Pericytes 0.006338246584825 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0081474500750471 0.0024832440877005 0.0 0.0 0.0 0.0 2541 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +984870 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0063354366779834 0.6303642896310324 0.7841656220878274 0.6198216015396206 0.0161193721503025 0.001309307002134 0.0 0.0045031055900621 0.5385952106976154 0.0 161 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +984898 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0063349810096559 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.0047694898966413 0.0042738820064046 0.0 0.0002009242515571 0.0145215239167956 0.0 1422 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +985062 CD34 SELP CD34-SELP Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0063325547627618 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0042829523358709 0.0045674276780054 0.0 0.0 0.0 0.0 246 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +985069 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0063325065253271 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0069047442087267 0.0032020139126304 0.0 0.0023696682464454 0.7643764097625265 0.0 422 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +985196 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0063302799829821 0.9184503888425788 0.4638256179742202 0.7204611100467462 0.0004696576149175 0.0446401662952339 0.0 0.0 0.0 0.0 1884 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +985243 VEGFC FLT1 VEGFC-FLT1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0063296599123698 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0012459853895406 0.0232163927704059 0.0 0.0 0.0 0.0 496 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +985376 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0063277787682348 0.6301823358791634 0.6347970925105053 0.8693461273411047 0.0031934983073077 0.0057802287131517 0.0 0.0002261420171867 0.0389053610804164 0.0 737 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +985382 CD34 SELP CD34-SELP Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0063277341419571 0.8963354148873306 0.6572093097629401 0.6198216015396206 0.0038492365148421 0.0045674276780054 0.0 0.0 0.0 0.0 129 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +985438 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.006327067505299 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0055862851962672 0.0032616151102094 0.0 0.0004395218002812 0.1391955272554517 0.0 1422 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +985521 C3 LRP1 C3-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0063257275509059 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0064915662046245 0.0028784826949613 0.0 0.0 0.0 0.0 407 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +985686 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.006323442854952 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0033537993821664 0.0501711964086628 0.0 0.0008284356633737 0.0167945715513432 0.0 727 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +985767 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.006322276888586 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0085570823799139 0.0040904475843412 0.0 0.0 0.0 0.0 5 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +985817 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0063215010076303 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0004094805141934 0.0501711964086628 0.0 0.0016839378238341 0.0484520461163299 0.0 193 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +985858 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0063209187741113 0.9184503888425788 0.6580560501976399 0.6198216015396206 0.0004696576149175 0.0362497659817488 0.0 0.0 0.0 0.0 409 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +985892 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.006320276809763 0.6342079770588467 0.6571792026963191 1.0 0.002196330917593 0.0069630688870869 0.0 0.0005663583160279 0.0715144830718128 0.0 5297 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +985982 VEGFC FLT1 VEGFC-FLT1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0063190859547474 0.8963332422588541 0.6593689120110077 0.6198216015396206 0.0026007495851186 0.0066828239855783 0.0 0.0 0.0 0.0 1354 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +986000 EFNB2 PECAM1 EFNB2-PECAM1 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0063189198504719 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0014623066995027 0.0125623889131764 0.0 0.0 0.0 0.0 4087 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +986122 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0063171828902038 0.6630837220165452 0.6587114738285964 0.9161861017439124 0.0037159398684439 0.0042738820064046 0.0 0.000875350140056 0.0632647273580985 0.0 408 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +986126 CD34 SELP CD34-SELP CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0063171269274108 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.1173076386135379 0.0001189339410417 0.0 0.0 0.0 0.0 11475 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +986231 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0063155371863235 0.633566764858408 0.7478729882108823 0.6198216015396206 0.0078992851324392 0.0027351735586246 0.0 0.0 0.0 0.0 129 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +986244 CD34 SELP CD34-SELP T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0063153422207128 0.633566764858408 0.4623922682986163 0.6198216015396206 0.015517736049123 0.0022515473538965 0.0 0.0 0.0 0.0 713 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +986338 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0063138542289364 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0049987108499989 0.0326412663903893 0.0 0.0 0.0 0.0 186 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +986436 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0063123281345811 0.6301823358791634 0.7461459456652184 0.6198216015396206 0.0208904415011529 0.0010390313650636 0.0 0.0 0.0 0.0 756 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +986499 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0063112306784031 0.8516956437178343 0.4641352222874551 0.7204611100467462 0.000472352586488 0.046975263367762 0.0 0.0 0.0 0.0 1041 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +986605 THBS2 CD36 THBS2-CD36 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0063097955510006 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0063387366560491 0.0032616151102094 0.0 0.0001041666666666 0.032989339959542 0.0 2400 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +986629 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0063094219091902 0.8718210606749883 0.4630488285702799 0.2461374514707439 0.0017670878089588 0.0359289752254096 0.0 0.0 0.0 0.0 1491 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +986741 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0063076474052498 0.7475533330314548 0.657421674383923 0.6198216015396206 0.0029751676683741 0.0069492509109592 0.0 0.0 0.0 0.0 160 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +986745 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0063076141946681 0.743507317541692 0.4630488285702799 0.2461374514707439 0.0020684923107111 0.0359289752254096 0.0 0.0 0.0 0.0 122 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +986929 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0063048392944248 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0015572459193676 0.0222228052993653 0.0 0.0 0.0 0.0 157 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +987000 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0063037944721491 0.2486570577556728 0.7346293219749174 0.2461374514707439 0.0033537993821664 0.0416128058995347 0.0 0.0003946061422487 0.0163613260625675 0.0 13362 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +987002 VWF LRP1 VWF-LRP1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0063037688432451 0.7158082793127664 0.7346293219749174 0.8293805866303694 0.0003457348439318 0.0416128058995347 0.0 0.0001402918069584 0.0058168379855264 0.0 324 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +987054 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0063031925533396 0.6593525851613742 0.8331580262014722 0.6198216015396206 0.0120646829101097 0.001526625481682 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +987144 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0063019634725842 0.6582846571368821 0.7461459456652184 0.6198216015396206 0.0198024073017111 0.0010390313650636 0.0 0.0043478260869565 0.637578257293641 0.0 23 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +987199 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.00630099692902 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0033537993821664 0.0487643047611538 0.0 0.0003751406777541 0.0146840760807417 0.0 727 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +987215 VWF LRP1 VWF-LRP1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0063006821200339 0.9011206516381156 0.6207977546603366 0.6198216015396206 0.0008850282134344 0.0203874717835032 0.0 0.0001147842056932 0.0053745142136084 0.0 594 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +987317 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0062992424829712 0.633566764858408 0.941479368642921 0.6198216015396206 0.0078992851324392 0.0021392900294222 0.0 0.0 0.0 0.0 475 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +987394 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0062981280335951 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0055862851962672 0.0031731220372828 0.0 0.0001068376068376 0.0478942295577871 0.0 390 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +987500 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0062964665060294 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0172764782878141 0.0011388334136451 0.0 0.0001433075379764 0.0190795556740928 0.0 1163 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +987531 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0062960769841903 0.6593525851613742 0.777821334064334 0.7917001487310438 0.0120646829101097 0.001271575589586 0.0 0.0 0.0 0.0 38 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +987581 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0062954778207767 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0065101973396288 0.0043013567716651 0.0 0.0 0.0 0.0 239 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +987627 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0062949124886254 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0024635726452692 0.0079745943515326 0.0 0.0 0.0 0.0 83 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +987656 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.00629449846867 0.8949858186325867 0.7480927101953669 0.7827641335561659 0.001895566065636 0.006260692484444 0.0 0.0 0.0 0.0 179 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +987735 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0062931756390255 0.8718210606749883 0.7472387841445823 0.7827641335561659 0.0017670878089588 0.0068935067166085 0.0 0.0003168567807351 0.0192668040135889 0.0 526 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +987839 VWF ITGA9 VWF-ITGA9 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0062915740221326 0.2486570577556728 0.9404022517663844 0.2461374514707439 0.0001077515101466 1.0 0.0 0.0121212121212121 0.1353453600031965 0.0 15 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +987860 CD34 SELP CD34-SELP Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0062912767924955 0.7871981482311898 0.7478729882108823 1.0 0.0038506427265089 0.0027351735586246 0.0 0.0017667844522968 0.5166874303324376 0.0 1132 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +987967 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.006289610003452 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0213929720256037 0.0007400708115376 0.0 0.0 0.0 0.0 81 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +987987 CCN1 CAV1 CCN1-CAV1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0062892450568225 0.8619922139338987 0.62431395375366 0.6198216015396206 0.0054092055025683 0.0034299077593249 0.0 0.0 0.0 0.0 129 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +988003 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.006289062082245 0.8913986641324685 0.6331674633943454 0.6198216015396206 0.0054950348959687 0.0032187363284526 0.0 0.0001846381093057 0.0363700323218617 0.0 1354 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +988136 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0062874462912581 0.7205550478301406 0.8347945881127203 0.7204611100467462 0.0117842887908422 0.0012097093680331 0.0 0.0 0.0 0.0 1082 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +988197 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0062863549526003 0.4636527906642655 0.8331580262014722 0.7204611100467462 0.014525360548861 0.001526625481682 0.0 0.0 0.0 0.0 38 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +988230 VWF ITGA9 VWF-ITGA9 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0062857738955096 0.6332974881236617 0.7831795333113832 0.6198216015396206 0.0036144684673052 0.0055509879377996 0.0 0.0002518257365902 0.0187803371532766 0.0 361 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +988359 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0062838449252822 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.011891719340537 0.0016667952436519 0.0 0.0 0.0 0.0 570 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +988369 HSPG2 LRP1 HSPG2-LRP1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.006283722706205 0.8349903778527206 0.9078204025796472 0.8567148457705164 0.0014804857410621 0.0064028969591119 0.0 0.002346096096096 0.2776174923507134 0.0 148 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +988556 THBS2 CD36 THBS2-CD36 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.006280935079755 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0063387366560491 0.0031731220372828 0.0 0.0004295532646048 0.1925644281189379 0.0 97 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +988615 CD48 CD2 CD48-CD2 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.006279979929623 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0161888123016941 0.0014748371602574 0.0 0.0 0.0 0.0 38 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +988754 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0062781992940959 0.7941469661104034 0.7426180951053148 0.6198216015396206 0.0323110954490285 0.0005184623914895 0.0 0.0022675736961451 0.2667408902187277 0.0 21 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +988843 CD34 SELP CD34-SELP Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0062769519366271 0.8963354148873306 0.4623922682986163 0.7204611100467462 0.0038492365148421 0.0053213839468185 0.0 0.0 0.0 0.0 715 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +988882 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0062762291818829 0.8684504425765611 0.4630027772793905 0.2461374514707439 0.0126216524880575 0.0048929293424311 0.0 0.0 0.0 0.0 383 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +988937 HSPG2 LRP1 HSPG2-LRP1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0062752712575185 0.7789175740361626 0.6207977546603366 0.9318789094584046 0.0012941512528773 0.0104714078116759 0.0 0.0001448790816895 0.0121100035817267 0.0 4985 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +988954 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0062751224411824 0.9219165193585238 0.8617632615906476 0.8567148457705164 0.0086134406931133 0.0010414441948928 0.0 0.0 0.0 0.0 137 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +988965 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0062750012389427 0.7205550478301406 0.7154802332407408 0.8293805866303694 0.0151307911035231 0.0009436211854823 0.0 0.0 0.0 0.0 219 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +989050 VWF LRP1 VWF-LRP1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0062737376541374 0.7848266128497919 0.6207977546603366 0.6198216015396206 0.0004024409845247 0.0501711964086628 0.0 0.0003342245989304 0.0067756123850313 0.0 170 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +989097 CCN1 CAV1 CCN1-CAV1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0062731771580847 0.7324582304061453 0.8818704453527788 0.7204611100467462 0.0025580826958339 0.0051192928876727 0.0 0.0004945598417408 0.0931724626666001 0.0 337 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +989134 CD34 SELP CD34-SELP Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0062726244716628 0.8963354148873306 0.7760344326192508 0.6198216015396206 0.0038492365148421 0.0036702914086929 0.0 0.0 0.0 0.0 594 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +989152 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0062724556397718 0.8023917560710954 0.7754239189773715 0.7204611100467462 0.0085367158000785 0.0015914585039484 0.0 0.0001477716042085 0.0717416517287731 0.0 1538 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +989157 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0062723850573634 0.7205550478301406 0.7461459456652184 0.7204611100467462 0.0151307911035231 0.0010390313650636 0.0 0.0 0.0 0.0 51 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +989234 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0062712555809059 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0037243679732516 0.0050968401714881 0.0 0.0 0.0 0.0 262 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +989273 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0062706136186095 0.7205550478301406 0.4630027772793905 0.2461374514707439 0.0151307911035231 0.0048929293424311 0.0 0.0003705148205928 0.0762001651004278 0.0 12820 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +989313 VWF SELP VWF-SELP B Cells Pericytes B Cells -> Pericytes 0.006270139333069 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.00023686843287 0.0741032966028748 0.0 0.0003753471961564 0.0086571739895923 0.0 1211 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +989384 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0062691521412789 0.6301823358791634 0.4630027772793905 0.2461374514707439 0.0172764782878141 0.0048929293424311 0.0 0.0 0.0 0.0 877 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +989579 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0062662301912599 0.8730912658940219 0.7462743270426613 0.7204611100467462 0.0057086106530109 0.0022591041672132 0.0 0.0 0.0 0.0 43 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +989616 C3 LRP1 C3-LRP1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0062654698692142 0.7148920381722296 0.2550748532138862 0.2461374514707439 0.005043231651446 0.0267255153180908 0.0 0.0001657566302652 0.0262434973210314 0.0 12820 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +989738 C1QB LRP1 C1QB-LRP1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0062632865707338 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0111808254589153 0.0018097844702233 0.0 0.0 0.0 0.0 377 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +989776 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0062627501920439 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0055862851962672 0.0030676679668133 0.0 0.0001251251251251 0.0815505929932383 0.0 1332 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +989884 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.006261438288555 0.6659645551150886 0.6614977577544194 0.9592803095773328 0.0037243679732516 0.0038288178384739 0.0 0.0 0.0 0.0 1476 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +989918 C3 LRP1 C3-LRP1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0062610513310716 0.8509500867818902 0.9078204025796472 0.8567148457705164 0.0006305085967044 0.0144359394371152 0.0 0.0001811594202898 0.0309374448016797 0.0 276 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +990001 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0062599327489787 0.6319926036888139 0.8604147465201248 0.6198216015396206 0.0004094805141934 0.0436001007095475 0.0 0.0 0.0 0.0 119 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +990008 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0062598740803801 0.4604235282221027 0.7779918296243433 0.2461374514707439 0.0126864732057784 0.0053794918117879 0.0 0.000237567310738 0.019334657341038 0.0 902 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +990046 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0062591913671009 0.7160288858520609 0.8923034233058523 0.7204611100467462 0.0069047442087267 0.00189193058407 0.0 0.0 0.0 0.0 591 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +990202 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0062571301094895 0.8516956437178343 0.4638256179742202 0.7204611100467462 0.000472352586488 0.0446401662952339 0.0 0.0 0.0 0.0 66 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +990441 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0062535946855701 0.6582846571368821 0.6587114738285964 0.9592803095773328 0.0198024073017111 0.0007261054236978 0.0 0.0005351170568561 0.0821810850227955 0.0 1495 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +990572 VWF ITGA9 VWF-ITGA9 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0062515089181767 0.6332974881236617 0.6252253442669611 0.909150863993142 0.0019871862905238 0.0083442542366581 0.0 5.783021050196623e-05 0.0031834317661917 0.0 1572 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +990579 VWF ITGA9 VWF-ITGA9 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0062514681636191 0.7848266128497919 0.6252253442669611 0.6198216015396206 0.0004024409845247 0.0487643047611538 0.0 0.0 0.0 0.0 170 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +990816 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0062478770745457 0.8516956437178343 0.6580560501976399 0.6198216015396206 0.000472352586488 0.0362497659817488 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +990820 A2M LRP1 A2M-LRP1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0062478424202174 0.7460047258226694 0.6207977546603366 0.6198216015396206 0.0010163752993685 0.0203874717835032 0.0 0.000514403292181 0.0305010467198194 0.0 162 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +990851 CCN1 CAV1 CCN1-CAV1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0062475146830249 0.7324582304061453 0.62431395375366 0.6198216015396206 0.0025580826958339 0.0082011408892332 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +990854 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.006247463341 0.2490567623945399 0.8818326005152037 0.2461374514707439 0.000126812416921 0.8672894033034337 0.0 0.0 0.0 0.0 9 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +990873 MMP2 PECAM1 MMP2-PECAM1 Pericytes Mast Cells Pericytes -> Mast Cells 0.0062472077593271 0.9067635403815892 0.8537710813834968 0.8567148457705164 0.0216588811659259 0.0004138063814779 0.0 0.0022222222222222 0.3235037949483639 0.0 225 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +991024 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0062450023716395 0.9219165193585238 0.62431395375366 0.6198216015396206 0.0086134406931133 0.0019304335593669 0.0 0.0005056890012642 0.1248510101349468 0.0 791 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +991177 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.006242963033664 0.6342079770588467 0.7746834992804791 0.909150863993142 0.0028649117803088 0.0046263543438723 0.0 2.8148398356133533e-05 0.0153445401533821 0.0 5921 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +991372 VWF SELP VWF-SELP Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0062401380096025 0.9011206516381156 0.4623922682986163 0.7204611100467462 0.0008850282134344 0.0222228052993653 0.0 3.7280742632393245e-05 0.0061732982481371 0.0 9754 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +991734 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0062348828342415 0.7158082793127664 0.7292496872084557 0.8293805866303694 0.0025256125075084 0.0053724660607752 0.0 0.0 0.0 0.0 219 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +991904 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0062323543378 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.000716220684292 0.0292771742399634 0.0 0.0021645021645021 0.2479636271040533 0.0 77 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +991921 CD48 CD2 CD48-CD2 Pericytes CAFs, Invasive Associated Pericytes -> CAFs, Invasive Associated 0.0062321560381514 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0076331962782219 0.0024251058581756 0.0 0.0002110595187842 0.0339365587765577 0.0 2369 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +991934 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0062320293631726 0.7451589345683471 0.6331674633943454 0.6198216015396206 0.0040724665904272 0.0049190726392343 0.0 0.0 0.0 0.0 144 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +992023 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.006230659793983 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.000219642761279 0.12709315903692 0.0 0.0002411146011182 0.0113586540044518 0.0 10961 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +992069 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0062298284041844 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0025256125075084 0.0083442542366581 0.0 0.0009229349330872 0.0508056318421662 0.0 394 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +992223 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0062274803956692 0.8023917560710954 0.4596166826058663 0.2461374514707439 0.0085367158000785 0.0075270071967493 0.0 0.0002552829385902 0.1126906161100131 0.0 12820 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +992251 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0062271824206696 0.633566764858408 0.4623922682986163 0.2461374514707439 0.0083565457974945 0.0096770075292062 0.0 0.0 0.0 0.0 351 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +992276 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0062268075007265 0.8840293712888387 0.6587114738285964 0.6198216015396206 0.0061698665784747 0.0026174949623928 0.0 0.0002564102564102 0.0347860625798229 0.0 390 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +992358 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0062256521594188 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0002327631000826 0.1370986982961073 0.0 0.0 0.0 0.0 496 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +992431 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0062246630940234 0.6332974881236617 0.6252253442669611 0.8693461273411047 0.0020251995753771 0.0083442542366581 0.0 0.0 0.0 0.0 270 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +992433 VWF SELP VWF-SELP Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0062245977605111 0.2486570577556728 0.8819126042133903 0.2461374514707439 0.0001077515101466 1.0 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +992451 CCN1 CAV1 CCN1-CAV1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0062243500207921 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0023088899408624 0.0082011408892332 0.0 0.0 0.0 0.0 50 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +992609 COL4A2 CD93 COL4A2-CD93 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0062221633162208 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0033449520260795 0.0042738820064046 0.0 0.0005165289256198 0.0439438473602099 0.0 968 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +992680 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0062210604225336 0.6303682835571691 0.8891607331132086 0.6198216015396206 0.0002750231449378 0.0606680526002441 0.0 0.0009219175885842 0.0304887166436388 0.0 594 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +992762 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.006219803752994 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0208904415011529 0.0007880862995141 0.0 6.830601092896175e-05 0.0456118438843237 0.0 4880 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +992813 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0062189671618211 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0001959417442809 0.088850508457521 0.0 0.0 0.0 0.0 119 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +992877 CD48 CD2 CD48-CD2 Pericytes Mast Cells Pericytes -> Mast Cells 0.0062180832313308 0.7719609236370527 0.7763428264267787 0.8567148457705164 0.0076331962782219 0.0014748371602574 0.0 0.0 0.0 0.0 225 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +992896 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0062177766312997 0.2451358214448441 0.8445107771175474 0.2461374514707439 0.1327555461750915 0.0008542071298387 0.0 0.0043290043290043 0.7995431182181614 0.0 176 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +992931 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Pericytes Basal-like Structured DCIS Cells -> Pericytes 0.0062171749541509 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0021291294377375 0.0091569531245039 0.0 0.0001260525386981 0.0329937659231362 0.0 1803 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +993041 VWF LRP1 VWF-LRP1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0062154284722477 0.8525936146535493 0.8604147465201248 0.8567148457705164 0.0002103933337194 0.0436001007095475 0.0 0.0011707988980716 0.0223339058041361 0.0 165 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +993285 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0062117845786561 0.4625081978296446 0.885766439573873 0.7204611100467462 0.0141498126994191 0.0013756087909864 0.0 0.0010893246187363 0.4104476268887095 0.0 306 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +993703 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0062049773330284 0.6213271600240247 0.7832252605020791 0.6198216015396206 0.013905026986541 0.00136079311934 0.0 0.0 0.0 0.0 361 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +993732 MMP2 PECAM1 MMP2-PECAM1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.006204390461103 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0216588811659259 0.0007400708115376 0.0 0.0002652519893899 0.0611283529856743 0.0 377 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +993743 C3 LRP1 C3-LRP1 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0062041271366097 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0091898156146168 0.0018097844702233 0.0 0.0 0.0 0.0 377 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +993748 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0062040868986061 0.6303682835571691 0.8891607331132086 0.6198216015396206 0.0002705513462707 0.0606680526002441 0.0 0.0022675736961451 0.0749908806887016 0.0 126 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +993758 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0062039537110677 0.8730912658940219 0.6631822525600675 0.6198216015396206 0.0057086106530109 0.0027830389352876 0.0 0.0 0.0 0.0 8 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +993876 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.006202414547015 0.6303642896310324 0.7841656220878274 0.6198216015396206 0.0141923232885854 0.001309307002134 0.0 0.0004155124653739 0.0496974852931413 0.0 361 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +993921 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0062018254710221 0.8937519114898692 0.7346293219749174 0.7204611100467462 0.0037268694422441 0.0032275631628407 0.0 0.0002923976608187 0.0172678519837874 0.0 285 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +993979 CCN1 CAV1 CCN1-CAV1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0062010712572254 0.6213271600240247 0.62431395375366 0.909150863993142 0.0083518627398662 0.0019304335593669 0.0 0.0001060220525869 0.026176089115973 0.0 1572 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +993980 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0062010573947844 0.7205550478301406 0.2491545808994955 0.2461374514707439 0.0117842887908422 0.0109188419829382 0.0 0.0003187297171998 0.0458821641479728 0.0 5752 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +993988 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0062009112667312 0.2486570577556728 0.2550748532138862 1.0 0.0033537993821664 0.0267255153180908 0.0 0.0001758177946964 0.0096147806003991 0.0 77495 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +994054 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0061997491346339 0.6342079770588467 0.8923034233058523 0.6198216015396206 0.0085570823799139 0.00189193058407 0.0 0.0 0.0 0.0 103 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +994076 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0061993818199185 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0151307911035231 0.001079730675535 0.0 0.0012690355329949 0.1393874814707051 0.0 394 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +994116 COL4A2 CD93 COL4A2-CD93 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0061989484638596 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.0047240947268779 0.0053794918117879 0.0 0.0 0.0 0.0 126 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +994201 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0061979070108277 0.785133132759182 0.6331674633943454 0.6198216015396206 0.001039571291679 0.0176963220730796 0.0 0.0002577319587628 0.0341362265568424 0.0 388 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +994203 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0061978958599182 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0071496754272206 0.0028784826949613 0.0 0.0002438548575887 0.0247155630981699 0.0 233 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +994211 VWF SELP VWF-SELP T Lymphocytes Basal-like Structured DCIS Cells T Lymphocytes -> Basal-like Structured DCIS Cells 0.0061978083826706 0.6332974881236617 0.7760344326192508 0.8693461273411047 0.0036144684673052 0.0036702914086929 0.0 0.0 0.0 0.0 737 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +994221 VWF LRP1 VWF-LRP1 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0061977463746873 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0003457348439318 0.0350138403862125 0.0 0.0003016894609814 0.0123236525292566 0.0 452 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +994263 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0061970004562308 0.8949858186325867 0.8818326005152037 0.8875000050982297 0.001895566065636 0.0042655619249233 0.0 0.0 0.0 0.0 1462 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +994273 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0061968076926277 0.7158082793127664 0.7831795333113832 0.7204611100467462 0.0025256125075084 0.0055509879377996 0.0 0.0 0.0 0.0 51 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +994390 C3 LRP1 C3-LRP1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.006195030797119 0.6319926036888139 0.7769451595923457 0.6198216015396206 0.0334108479684367 0.0005558995075445 0.0 0.0022160664819944 0.4968071689255677 0.0 361 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +994448 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0061942414703664 0.7800321422220979 0.7841656220878274 0.6198216015396206 0.0113788029360913 0.001309307002134 0.0 0.0 0.0 0.0 161 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +994469 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0061938620253341 0.7840818683779507 0.7746834992804791 0.6198216015396206 0.0032417203409647 0.0046263543438723 0.0 0.0 0.0 0.0 388 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +994563 CD34 SELP CD34-SELP Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0061926553975992 0.7871981482311898 0.6572093097629401 0.6198216015396206 0.0038506427265089 0.0045674276780054 0.0 0.0 0.0 0.0 30 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +994598 CD48 CD2 CD48-CD2 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0061921782758926 0.7453966474499909 0.4603649459881741 0.2461374514707439 0.006326966401379 0.0105486447632276 0.0 0.0 0.0 0.0 122 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +994610 VWF SELP VWF-SELP CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0061920660352485 0.7158082793127664 0.4623922682986163 0.2461374514707439 0.0071496754272206 0.0096770075292062 0.0 0.0001027310658743 0.0293071920288073 0.0 5752 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +994696 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0061906915702514 0.4636527906642655 0.777821334064334 0.6198216015396206 0.0023125636768155 0.0108892901157311 0.0 0.0 0.0 0.0 271 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +994788 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0061893079634351 0.2534163760166434 0.4638256179742202 0.2461374514707439 0.2100740470724093 0.0009249287638231 0.0 0.0006127450980392 0.3527682076191014 0.0 272 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +994987 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.006185970591472 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0053032910137447 0.0032020139126304 0.0 0.0008598452278589 0.2773575622698075 0.0 1163 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +995005 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0061856898173884 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.0012814156885439 0.0144359394371152 0.0 0.0005700663349917 0.0498846690713284 0.0 536 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +995121 VWF LRP1 VWF-LRP1 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0061838457873335 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0003457348439318 0.0587195251380622 0.0 0.0 0.0 0.0 148 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +995152 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0061833286054267 0.8937519114898692 0.2550748532138862 0.2461374514707439 0.0037268694422441 0.0267255153180908 0.0 0.0008104180639391 0.0704961706484496 0.0 1491 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +995179 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.006182918519572 0.8624864526942296 0.8818326005152037 0.8567148457705164 0.0020100505037262 0.0042655619249233 0.0 0.0 0.0 0.0 148 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +995278 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0061813037563934 0.6160088550075702 0.4596166826058663 0.2461374514707439 0.0106340017102282 0.0075270071967493 0.0 0.0009881422924901 0.4361997882036139 0.0 184 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +995328 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0061804461504918 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0151307911035231 0.0007880862995141 0.0 0.0006501950585175 0.4341725581706759 0.0 1538 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +995335 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Myoepithelial Cells 11q13 Invasive Tumor Cells -> Myoepithelial Cells 0.0061803997157029 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0034559943126159 0.0056518532344078 0.0 4.03512169927045e-05 0.033434626515432 0.0 5163 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +995346 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0061802604595873 0.2486570577556728 0.6572093097629401 0.2461374514707439 0.0033537993821664 0.04130664769978 0.0 0.0 0.0 0.0 186 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +995400 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0061794176741755 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0009153913192522 0.0203874717835032 0.0 0.0002815315315315 0.0159432473325688 0.0 1332 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +995459 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0061784714191941 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0093830613230477 0.0019304335593669 0.0 0.0 0.0 0.0 42 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +995483 C1QB LRP1 C1QB-LRP1 Pericytes B Cells Pericytes -> B Cells 0.0061779570269099 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0111808254589153 0.0016667952436519 0.0 0.0001763875823142 0.0310046867841395 0.0 1063 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +995494 VWF ITGA9 VWF-ITGA9 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.006177723682418 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0036144684673052 0.0053724660607752 0.0 0.000127502231289 0.0123152511043339 0.0 713 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +995498 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0061777162719978 0.6303682835571691 0.4614667734221426 0.8767341187813953 0.0101610580570933 0.0021449819680126 0.0 0.0007667967309222 0.0278285457883375 0.0 2453 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +995528 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.006177330127075 0.6301823358791634 0.6587114738285964 0.8824495942126559 0.0208904415011529 0.0007261054236978 0.0 6.239600665557404e-05 0.0076405341483236 0.0 12020 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +995563 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.006176816680769 0.7160288858520609 0.7470475610360806 0.7204611100467462 0.0186793449598515 0.0007714919761827 0.0 0.0001261670451678 0.0365993330719689 0.0 1321 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +995646 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0061754556569422 0.6249837837987587 0.8923034233058523 0.6198216015396206 0.0084812136822336 0.00189193058407 0.0 0.0 0.0 0.0 119 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +995683 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0061749224927067 0.6303682835571691 0.7426180951053148 0.7827641335561659 0.0291791383241764 0.0005184623914895 0.0 0.001148175006043 0.1350629634483152 0.0 394 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +995702 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0061747185516212 0.7789175740361626 0.6207977546603366 0.909150863993142 0.0075637985935472 0.0016667952436519 0.0 0.0003710771840542 0.0469468176008718 0.0 1572 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +995838 COL4A1 CD93 COL4A1-CD93 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0061723511768464 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0168149984327668 0.0007261054236978 0.0 0.0 0.0 0.0 209 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +995919 CD34 SELP CD34-SELP Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0061713748083329 0.8963354148873306 0.7478729882108823 0.7827641335561659 0.0038492365148421 0.0027351735586246 0.0 0.0 0.0 0.0 179 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +995920 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0061713573590243 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0267593032157803 0.0009242223287825 0.0 0.001673640167364 0.3191644991891976 0.0 239 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +995925 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0061712158988432 0.6630837220165452 0.6587114738285964 1.0 0.0048313935743179 0.0026174949623928 0.0 0.0002761413843888 0.0269170333751298 0.0 1552 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +995955 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0061708644626684 0.2490567623945399 0.7754072541855492 0.2461374514707439 0.011649387573427 0.009971631136135 0.0 0.0 0.0 0.0 727 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +996028 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0061700552080246 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0073929685753755 0.0040904475843412 0.0 0.0 0.0 0.0 713 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +996069 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0061694767967997 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0021291294377375 0.0080072638027924 0.0 0.0001460778107805 0.035285220239406 0.0 1867 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +996096 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.006169051920137 0.633566764858408 0.4623922682986163 0.2461374514707439 0.0078992851324392 0.0096770075292062 0.0 0.0 0.0 0.0 877 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +996112 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0061687391611231 0.255669001367946 0.4600037439857229 0.2461374514707439 0.0061207051981986 0.0310998965832685 0.0 0.0002329091281745 0.0439530122863414 0.0 4879 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +996129 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.006168507789538 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0208904415011529 0.0009436211854823 0.0 0.0 0.0 0.0 103 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +996165 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0061681355884822 0.9197297916541942 0.7763054211764489 0.7827641335561659 0.0055862851962672 0.0017638974017382 0.0 0.0003960709759188 0.0568790566890084 0.0 526 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +996176 MMRN2 CD93 MMRN2-CD93 B Cells Macrophages B Cells -> Macrophages 0.0061680115495428 0.6301823358791634 0.944024288971064 0.6198216015396206 0.0003083910058032 0.0484215930647349 0.0 0.0002347417840375 0.0052522571527007 0.0 1065 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +996230 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0061673274819899 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0078992851324392 0.002113171886167 0.0 0.0 0.0 0.0 1867 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +996260 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0061667736291878 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0003521782369754 0.0501711964086628 0.0 0.0001177578897786 0.002387262394726 0.0 193 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +996287 DLL1 NOTCH3 DLL1-NOTCH3 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0061664448763354 0.6249837837987587 0.7746834992804791 0.9318789094584046 0.00263399584678 0.0046263543438723 0.0 6.686726847208291e-05 0.0235226463500138 0.0 4985 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +996314 C1QB LRP1 C1QB-LRP1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0061659963091642 0.8703788833238396 0.2550748532138862 0.2461374514707439 0.0037630364713574 0.0267255153180908 0.0 0.0 0.0 0.0 211 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +996621 THBS2 CD36 THBS2-CD36 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0061613193730233 0.8581959463413404 0.7373999388878224 0.7204611100467462 0.0002636300075004 0.0455125113141721 0.0 8.005123278898494e-05 0.0182026327001754 0.0 1041 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +996770 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.006159022570014 0.6249837837987587 0.7470475610360806 0.6198216015396206 0.0244483651952677 0.0007714919761827 0.0 0.0072463768115942 1.0 0.0 23 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +996813 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0061583168963933 0.8667347161816407 0.7464347811605867 0.6198216015396206 0.0106228227237899 0.0012805120781881 0.0 0.0 0.0 0.0 129 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +996831 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0061579518577664 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0170183763647696 0.0018097844702233 0.0 0.0005924170616113 0.0653572452544623 0.0 422 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +996991 VWF SELP VWF-SELP T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0061555247469722 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0036144684673052 0.0045674276780054 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +996996 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0061554282084022 0.4629984640915818 0.7346293219749174 0.2461374514707439 0.0201301851612071 0.0032275631628407 0.0 0.0009191176470588 0.0505373416572202 0.0 272 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +997134 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0061537471549337 0.255669001367946 0.8950084308969304 0.2461374514707439 0.0002269856810233 0.4247538686915498 0.0 0.0021306818181818 0.0219640975169825 0.0 64 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +997155 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0061535430316046 0.8571898293845529 0.7154802332407408 0.7204611100467462 0.0004196880356983 0.0292771742399634 0.0 0.0003202049311559 0.0366824193794661 0.0 1041 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +997170 VWF ITGA9 VWF-ITGA9 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.006153259308759 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0003457348439318 0.0565946652887153 0.0 0.0006379585326953 0.0235982590899156 0.0 285 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +997277 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0061517563605783 0.6659645551150886 0.7464347811605867 0.6198216015396206 0.0137371823984124 0.0012805120781881 0.0 0.0 0.0 0.0 23 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +997278 MMRN2 CLEC14A MMRN2-CLEC14A B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0061517289950676 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0003083910058032 0.0554888093272979 0.0 0.0 0.0 0.0 797 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +997320 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0061512294339198 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0149256517769723 0.0012252690191386 0.0 0.0006901991717609 0.5537964172163711 0.0 922 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +997365 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0061505859945166 0.255669001367946 0.4596166826058663 1.0 0.0061207051981986 0.0075270071967493 0.0 0.000102645918505 0.0453114174467914 0.0 77495 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +997728 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0061448838221166 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0003521782369754 0.0487643047611538 0.0 0.0 0.0 0.0 193 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +997821 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0061435585106605 0.7475533330314548 0.657421674383923 0.6198216015396206 0.0029751676683741 0.0059327142047454 0.0 0.0 0.0 0.0 32 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +997860 CD34 SELP CD34-SELP Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0061429572448507 0.7871981482311898 0.4623922682986163 0.7204611100467462 0.0038506427265089 0.0053213839468185 0.0 0.0 0.0 0.0 85 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +997871 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0061427625429137 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0048313935743179 0.0058437228618857 0.0 0.0003001200480192 0.0731507860223147 0.0 714 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +997928 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0061417019133983 0.6342079770588467 0.8818120773736414 0.6198216015396206 0.0028649117803088 0.0054043611446182 0.0 0.0 0.0 0.0 1633 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +997944 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.006141490380207 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0131302879503246 0.0022515473538965 0.0 0.0 0.0 0.0 103 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +998044 VWF ITGA9 VWF-ITGA9 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.006139675799659 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0036144684673052 0.0047273851759697 0.0 0.0 0.0 0.0 81 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +998110 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0061387254562867 0.2486570577556728 0.7760344326192508 0.2461374514707439 0.0033537993821664 0.0335947364052305 0.0 0.0001438434982738 0.0076949237048569 0.0 316 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +998111 CD34 SELP CD34-SELP Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0061387221586938 0.7871981482311898 0.7760344326192508 0.6198216015396206 0.0038506427265089 0.0036702914086929 0.0 0.0 0.0 0.0 162 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +998204 COL4A2 CD93 COL4A2-CD93 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0061373946690978 0.8355319038299565 0.7779918296243433 0.6198216015396206 0.001123788079051 0.0118035014556376 0.0 0.0002915451895043 0.0295038031054041 0.0 343 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +998224 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0061371402773491 0.6332974881236617 0.6572093097629401 0.8824495942126559 0.0003521782369754 0.04130664769978 0.0 3.007744943228815e-05 0.0102087220962476 0.0 12090 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +998233 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0061369908607858 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0061207051981986 0.0178869147172998 0.0 0.0002265176683781 0.0387235214391138 0.0 1806 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +998346 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.006135163056092 0.2451358214448441 0.773263018678637 0.2461374514707439 0.1327555461750915 0.0008609682710384 0.0 0.0010838150289017 0.3251547853704371 0.0 1384 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +998393 CD34 SELP CD34-SELP T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0061346049911739 0.633566764858408 0.6572093097629401 0.7917001487310438 0.015517736049123 0.0010419094417808 0.0 0.0 0.0 0.0 81 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +998462 CD34 SELP CD34-SELP Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0061334118166271 0.8963354148873306 0.7760344326192508 0.6198216015396206 0.0038492365148421 0.0032078747392388 0.0 0.0 0.0 0.0 1687 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +998470 CD34 SELP CD34-SELP CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0061332837421287 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0298399317533219 0.0004582650848664 0.0 0.0005452562704471 0.4057030173673069 0.0 917 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +998528 COL4A1 CD93 COL4A1-CD93 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0061324095562692 0.8684504425765611 0.7779918296243433 0.8693461273411047 0.0016831757123532 0.0053794918117879 0.0 0.0 0.0 0.0 360 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +998574 VWF SELP VWF-SELP Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0061316807389704 0.7848266128497919 0.6572093097629401 0.6198216015396206 0.0004024409845247 0.04130664769978 0.0 3.938868756893021e-05 0.0133690912200643 0.0 1154 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +998781 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0061283777744234 0.7789175740361626 0.6207977546603366 0.9318789094584046 0.0070532058552773 0.0016667952436519 0.0 0.0001413838988689 0.0178871792638394 0.0 5010 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +998813 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0061278499559103 0.785133132759182 0.7167436199046466 0.7204611100467462 0.001039571291679 0.0125623889131764 0.0 0.0001920122887864 0.0618525365279181 0.0 1302 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +998820 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0061277713263751 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0009692519480124 0.0310998965832685 0.0 0.0 0.0 0.0 157 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +998855 CD34 SELP CD34-SELP Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.006127280225266 0.8532069650852002 0.4623922682986163 0.7204611100467462 0.00083777361258 0.0222228052993653 0.0 0.0009606147934678 0.2566892172764345 0.0 1041 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +998940 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0061259120212566 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0006856224272495 0.0312252462757311 0.0 0.0006893211118563 0.0375431394816275 0.0 1278 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +998994 COL4A1 CD93 COL4A1-CD93 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0061250561057556 0.7463064942968751 0.7779918296243433 0.6198216015396206 0.0012430446376512 0.0118035014556376 0.0 0.0 0.0 0.0 388 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +999068 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0061239496915902 0.6342079770588467 0.7480927101953669 0.6198216015396206 0.0028649117803088 0.006260692484444 0.0 0.0 0.0 0.0 161 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +999112 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.006123203256852 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0016171311116606 0.0104714078116759 0.0 9.881422924901184e-05 0.008296052089856 0.0 2300 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +999156 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0061225643427919 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0215813276111062 0.0005788283879716 0.0 0.0 0.0 0.0 1109 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +999158 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.006122528635551 0.8684504425765611 0.7461459456652184 0.6198216015396206 0.0126216524880575 0.0010390313650636 0.0 0.0005935892362485 0.056478259448746 0.0 361 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +999349 C3 LRP1 C3-LRP1 Pericytes B Cells Pericytes -> B Cells 0.0061196035670087 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0091898156146168 0.0016667952436519 0.0 0.0009877704609595 0.1814240621314056 0.0 1063 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +999498 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0061173316823392 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0075637985935472 0.0018097844702233 0.0 0.0005980861244019 0.0532095131550511 0.0 209 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +999608 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0061156249068157 0.6301823358791634 0.7461459456652184 0.6198216015396206 0.0172764782878141 0.0010390313650636 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +999785 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0061129364706873 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0031934983073077 0.0058465532256424 0.0 0.0 0.0 0.0 1278 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1000061 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0061087509992305 0.6561647292424944 0.6207977546603366 1.0 0.0070489045197697 0.0018097844702233 0.0 0.0003611412062116 0.0487293225285162 0.0 1846 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1000111 C1QB LRP1 C1QB-LRP1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0061079835399731 0.4601010570874773 0.9078204025796472 0.7204611100467462 0.0026949121497638 0.0064028969591119 0.0 0.0010212418300653 0.1049849933900712 0.0 306 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1000152 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0061073302194864 0.4593282471594782 0.6614977577544194 0.2461374514707439 0.0181222899145132 0.0038288178384739 0.0 0.0 0.0 0.0 373 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1000173 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0061070245452562 0.255669001367946 0.4600037439857229 0.2461374514707439 0.0061207051981986 0.0292791515533623 0.0 0.0026737967914438 0.0631346914224394 0.0 272 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1000187 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0061067123378284 0.6332974881236617 0.8604147465201248 0.6198216015396206 0.0003521782369754 0.0436001007095475 0.0 0.0018143621084797 0.0346103780009722 0.0 119 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1000264 VWF SELP VWF-SELP T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0061056446013179 0.6332974881236617 0.7760344326192508 0.909150863993142 0.0036144684673052 0.0032078747392388 0.0 0.0001261750047315 0.0209371475145888 0.0 5764 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1000333 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0061047148025367 0.255669001367946 0.4596166826058663 0.2461374514707439 0.0061207051981986 0.0292373734098458 0.0 0.0002211155107428 0.033765598545492 0.0 13362 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1000384 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0061040133874768 0.6589792304505506 0.6207977546603366 0.9592803095773328 0.0072827533047186 0.0018097844702233 0.0 0.0005574136008918 0.049591028982857 0.0 1495 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1000698 MMRN2 CD93 MMRN2-CD93 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0060989036043133 0.7856500335676843 0.6587114738285964 0.6198216015396206 0.0005542667491398 0.0289462771086338 0.0 0.0004332755632582 0.0895984592688774 0.0 1154 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1000735 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0060984368836017 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.0024635726452692 0.0053794918117879 0.0 0.0005747126436781 0.0693747917561181 0.0 1305 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1000806 MMRN2 CD93 MMRN2-CD93 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0060973331165298 0.7205550478301406 0.944024288971064 0.7204611100467462 0.0002165306714062 0.0484215930647349 0.0 0.0007418397626112 0.0165983794291581 0.0 337 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1000832 CD34 SELP CD34-SELP Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.006097017173535 0.7168245244832976 0.4623922682986163 0.8293805866303694 0.0082993421103349 0.0022515473538965 0.0 0.0 0.0 0.0 219 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1000849 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0060967870720081 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.000245041593909 0.0587195251380622 0.0 5.398877033577014e-05 0.0056146581259673 0.0 5683 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1000872 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0060964769148169 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0020251995753771 0.0642389143033604 0.0 0.0 0.0 0.0 877 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1000884 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.0060962338728718 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0009692519480124 0.0178869147172998 0.0 0.0002457002457002 0.0420028106420658 0.0 370 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1000989 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0060946199463863 0.7468485855611411 0.9078204025796472 0.7827641335561659 0.0006689050756654 0.0144359394371152 0.0 0.0006038647342995 0.0528422581467036 0.0 460 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1001013 THBS2 CD36 THBS2-CD36 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0060941669531666 0.6242573126045354 0.6176321640000088 0.8693461273411047 0.004981832968137 0.0030676679668133 0.0 0.0 0.0 0.0 1245 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1001029 CD34 SELP CD34-SELP Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.006093882273373 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.0082993421103349 0.002113171886167 0.0 0.0003201024327784 0.0927146887405298 0.0 1562 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1001033 CD48 CD2 CD48-CD2 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0060937970389621 0.4593282471594782 0.7464347811605867 0.7204611100467462 0.0161888123016941 0.0012805120781881 0.0 0.0 0.0 0.0 51 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1001101 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0060928782400945 0.2490567623945399 0.6580560501976399 0.2461374514707439 0.000126812416921 1.0 0.0 0.0 0.0 0.0 184 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1001148 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0060921280147289 0.6249837837987587 0.7746834992804791 0.909150863993142 0.0161757332769496 0.00071798405859 0.0 0.0001590330788804 0.1203891302708876 0.0 1572 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1001211 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0060913410430268 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.000393370777602 0.0455125113141721 0.0 0.0005307855626326 0.1206938894323734 0.0 157 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1001271 VWF SELP VWF-SELP Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0060904722201068 0.7848266128497919 0.7760344326192508 0.6198216015396206 0.0004024409845247 0.0335947364052305 0.0 0.0003514526710402 0.018800999155166 0.0 388 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1001297 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0060901851031886 0.4630253981438691 0.8347945881127203 0.2461374514707439 0.0443339118517084 0.0012097093680331 0.0 0.0 0.0 0.0 34 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1001353 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0060894358978968 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0004094805141934 0.0350138403862125 0.0 0.0005797101449275 0.0509255196924272 0.0 345 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1001470 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0060876828314151 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0037243679732516 0.0071918009517169 0.0 0.0 0.0 0.0 453 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1001508 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0060870961747589 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0415873844357376 0.0003375370073613 0.0 8.782201405152225e-05 0.0765222021844607 0.0 4880 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1001629 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, DCIS Associated 0.0060851238852013 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0014431743145616 0.0125623889131764 0.0 0.0001592356687898 0.0512942691460824 0.0 157 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1001648 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0060848146626232 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0015572459193676 0.0104714078116759 0.0 0.0002738225629791 0.0229890600080349 0.0 83 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1002013 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0060797505576931 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0016575843792215 0.0073658308476012 0.0 0.0002916047006677 0.0530937812633942 0.0 1633 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1002169 VWF ITGA9 VWF-ITGA9 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0060772541598643 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0019871862905238 0.0642389143033604 0.0 0.0008462282398452 0.0396067459796038 0.0 752 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1002208 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0060765336998816 0.9197297916541942 0.8587566561291643 1.0 0.0055862851962672 0.0011409783203169 0.0 0.0001347764783942 0.1029843759108032 0.0 4019 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1002245 VWF ITGA9 VWF-ITGA9 B Cells Mast Cells B Cells -> Mast Cells 0.0060761393220934 0.6332974881236617 0.863034163938375 0.6198216015396206 0.00023686843287 0.0627102121186242 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1002271 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0060758168849447 0.7160288858520609 0.4638256179742202 0.8767341187813953 0.0186793449598515 0.0009249287638231 0.0 0.0 0.0 0.0 2453 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1002287 COL4A2 CD93 COL4A2-CD93 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0060755617126127 0.9188764516910942 0.7461459456652184 0.7827641335561659 0.0090193130488293 0.0010390313650636 0.0 0.000558659217877 0.0819234632276745 0.0 179 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1002331 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0060749092329954 0.7205550478301406 0.7154802332407408 0.8767341187813953 0.0117842887908422 0.0009436211854823 0.0 0.000203832042397 0.0226735542166681 0.0 2453 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1002340 COL4A1 CD93 COL4A1-CD93 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0060747235451607 0.4604235282221027 0.4630027772793905 0.8767341187813953 0.0017253404164066 0.0155837683010033 0.0 0.0002915451895043 0.0686975695684844 0.0 2450 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1002354 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0060746093402193 0.6332974881236617 0.6572093097629401 0.8824495942126559 0.0131302879503246 0.0010419094417808 0.0 6.0505218575102114e-05 0.0356615053793401 0.0 12020 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1002396 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0060740573693092 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0170183763647696 0.0016667952436519 0.0 0.0019035532994923 0.3345988025537093 0.0 394 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1002510 C3 LRP1 C3-LRP1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0060722619216197 0.7796725988275006 0.6207977546603366 0.6198216015396206 0.000819605673545 0.0203874717835032 0.0 0.0007716049382716 0.0986970941585898 0.0 162 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1002537 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0060717611130507 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0106340017102282 0.0015914585039484 0.0 9.314456035767511e-06 0.0045220762442152 0.0 4880 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1002598 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0060708863510097 0.9275752708651288 0.7346293219749174 0.7204611100467462 0.000245041593909 0.0416128058995347 0.0 4.8253232966608766e-05 0.0020006958676333 0.0 1884 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1002634 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0060703612194174 0.2490567623945399 0.7746834992804791 0.2461374514707439 0.011649387573427 0.0090444648829713 0.0 0.0004585052728106 0.0520728569533234 0.0 727 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1002755 C1QB LRP1 C1QB-LRP1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0060688113188217 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0026949121497638 0.0104714078116759 0.0 0.0015770252324037 0.1577274173558696 0.0 753 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1002915 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0060666312024142 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.000245041593909 0.0565946652887153 0.0 0.0 0.0 0.0 1422 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1002928 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0060664665696574 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0009692519480124 0.0292791515533623 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1002979 HSPG2 LRP1 HSPG2-LRP1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0060657591828303 0.8349903778527206 0.6207977546603366 0.6198216015396206 0.0014804857410621 0.0104714078116759 0.0 0.0009718172983479 0.0812312642138255 0.0 343 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1003088 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0060641721664028 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0009692519480124 0.0292373734098458 0.0 0.0014005602240896 0.2138735274903473 0.0 714 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1003090 C3 LRP1 C3-LRP1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0060641275931814 0.7148920381722296 0.7346293219749174 1.0 0.0029337538459309 0.0032275631628407 0.0 0.0014134275618374 0.1310472792535057 0.0 283 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1003272 THBS2 CD36 THBS2-CD36 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0060614946680056 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.004981832968137 0.0032616151102094 0.0 0.0001942913663981 0.0615316217982132 0.0 2359 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1003322 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0060607929996919 0.940547666092272 0.944024288971064 0.8875000050982297 0.0001298888146421 0.0484215930647349 0.0 0.0 0.0 0.0 1424 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1003422 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0060592946028333 0.9184503888425788 0.7754072541855492 0.6198216015396206 0.0004696576149175 0.0238720285974944 0.0 0.0 0.0 0.0 1881 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1003424 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0060592800633543 0.7451589345683471 0.6331674633943454 0.6198216015396206 0.0040724665904272 0.0041555861088636 0.0 0.0 0.0 0.0 30 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1003971 COL4A2 CD93 COL4A2-CD93 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0060509750443941 0.4630253981438691 0.4630027772793905 0.8293805866303694 0.0047240947268779 0.0058437228618857 0.0 0.0003086419753086 0.0936605094009902 0.0 324 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1004011 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0060504775590664 0.6342079770588467 0.8923034233058523 0.6198216015396206 0.0073929685753755 0.00189193058407 0.0 0.000193742129226 0.0857108702246421 0.0 3441 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1004053 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0060499667641577 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0004094805141934 0.0416128058995347 0.0 0.0005518763796909 0.0515456048081498 0.0 453 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1004198 THBS2 CD36 THBS2-CD36 Pericytes Luminal-like Amorphous DCIS Cells Pericytes -> Luminal-like Amorphous DCIS Cells 0.0060477733818295 0.9197297916541942 0.2562573700401372 0.2461374514707439 0.0087456089304998 0.0096442330625583 0.0 0.0 0.0 0.0 1909 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1004273 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0060464871758708 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0070532058552773 0.0018097844702233 0.0 0.0006858710562414 0.061019414262857 0.0 81 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1004292 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0060461993151955 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0151307911035231 0.0011388334136451 0.0 0.0003949447077409 0.0525818086468483 0.0 422 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1004300 VWF LRP1 VWF-LRP1 Mast Cells Pericytes Mast Cells -> Pericytes 0.0060461437490507 0.8525936146535493 0.9078204025796472 0.8567148457705164 0.0002103933337194 0.0350138403862125 0.0 0.0013040238450074 0.0532678095663496 0.0 244 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1004377 COL4A2 CD93 COL4A2-CD93 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0060453257455616 0.8355319038299565 0.4630027772793905 0.7204611100467462 0.001123788079051 0.0155837683010033 0.0 0.0002881844380403 0.0796674287700216 0.0 1041 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1004483 MMP2 PECAM1 MMP2-PECAM1 B Cells B Cells B Cells -> B Cells 0.0060436531053335 0.6303642896310324 0.6331674633943454 1.0 0.0024819960935566 0.0049190726392343 0.0 0.0002820874471086 0.0344573294730042 0.0 1418 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1004571 A2M LRP1 A2M-LRP1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0060423367054968 0.8392912392980421 0.9078204025796472 0.8567148457705164 0.0005164482812395 0.0144359394371152 0.0 0.0003019323671497 0.0370428727084763 0.0 276 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1004594 VEGFC FLT1 VEGFC-FLT1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0060420866626261 0.8317042416754105 0.6593689120110077 0.6198216015396206 0.0005440770361181 0.026308073552735 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1004600 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Pericytes Dendritic Cells -> Pericytes 0.0060420002121036 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0016575843792215 0.0070956399217802 0.0 0.0006679468982215 0.0838297024534244 0.0 1711 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1004726 THBS2 CD36 THBS2-CD36 Myoepithelial Cells T Lymphocytes Myoepithelial Cells -> T Lymphocytes 0.0060403542828903 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0027791828709671 0.0063011237754475 0.0 0.0 0.0 0.0 1093 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1004881 VWF LRP1 VWF-LRP1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0060378883389728 0.2486570577556728 0.7346293219749174 0.2461374514707439 0.0001077515101466 1.0 0.0 0.0024259448416751 0.0186252172926142 0.0 89 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1005143 THBS2 CD36 THBS2-CD36 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0060337699040006 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.004981832968137 0.0031731220372828 0.0 0.0001693766937669 0.0759298761281991 0.0 246 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1005186 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0060331815504435 0.6160088550075702 0.7447682696221608 0.6198216015396206 0.0052742025956585 0.0032154705418133 0.0 0.0023224950232249 0.1971431097900599 0.0 137 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1005187 COL4A1 CD93 COL4A1-CD93 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0060331722767597 0.7463064942968751 0.4630027772793905 0.7204611100467462 0.0012430446376512 0.0155837683010033 0.0 5.486065393899495e-05 0.012926962015575 0.0 1302 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1005296 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0060313361771299 0.6342079770588467 0.836885603004631 0.6198216015396206 0.0053032910137447 0.0027591088867233 0.0 0.0 0.0 0.0 18 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1005301 C1QB LRP1 C1QB-LRP1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0060312847733103 0.8703788833238396 0.7346293219749174 0.6198216015396206 0.0037630364713574 0.0032275631628407 0.0 0.0004208754208754 0.0167725058087663 0.0 297 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1005320 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0060309380935443 0.8949858186325867 0.6571792026963191 0.6198216015396206 0.001895566065636 0.0069630688870869 0.0 0.0 0.0 0.0 1354 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1005385 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0060297303900661 0.6213271600240247 0.8617632615906476 0.6198216015396206 0.013905026986541 0.0010414441948928 0.0 0.0003003003003003 0.0379511072965382 0.0 333 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1005590 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0060265891248332 0.250044481781731 0.2491545808994955 1.0 0.0070431301838115 0.0109188419829382 0.0 0.0001311912596511 0.0188854022241053 0.0 77495 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1005610 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0060262581590164 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0048525806497539 0.0028784826949613 0.0 0.0001282051282051 0.0331704325854274 0.0 390 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1005624 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0060259837474118 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0172764782878141 0.0007880862995141 0.0 0.0003005710850616 0.200708564612714 0.0 1109 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1005757 CD34 SELP CD34-SELP Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.006024051035732 0.7871981482311898 0.941479368642921 0.7827641335561659 0.0038506427265089 0.0021392900294222 0.0 0.0 0.0 0.0 162 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1005771 VWF LRP1 VWF-LRP1 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0060238013273405 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0003457348439318 0.0501711964086628 0.0 0.002180476350218 0.0442039951909057 0.0 271 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1005951 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0060212789437456 0.6303682835571691 0.7426180951053148 0.7204611100467462 0.0272543760657653 0.0005184623914895 0.0 0.0004668534080298 0.0549172421038557 0.0 51 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1006050 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0060196125115869 0.4601010570874773 0.7346293219749174 0.2461374514707439 0.0177188549930425 0.0032275631628407 0.0 0.0004595588235294 0.0183140964161897 0.0 272 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1006078 C3 LRP1 C3-LRP1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0060191488223572 0.6319926036888139 0.8755243548400705 0.6198216015396206 0.0334108479684367 0.0004150165744076 0.0 0.0012762762762762 0.3678607682390367 0.0 333 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1006190 CXCL12 ITGA4 CXCL12-ITGA4 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0060174133484686 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0052742025956585 0.0027830389352876 0.0 0.0021645021645021 0.6737458806298063 0.0 42 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1006246 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0060164412753483 0.7205550478301406 0.7461459456652184 0.7204611100467462 0.0117842887908422 0.0010390313650636 0.0 0.0 0.0 0.0 1321 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1006306 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0060156563372328 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0161193721503025 0.0076066460958003 0.0 0.001063829787234 0.4489788689311002 0.0 752 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1006355 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated -> Luminal-like Amorphous DCIS Cells 0.0060147421199013 0.7205550478301406 0.4630027772793905 0.2461374514707439 0.0117842887908422 0.0048929293424311 0.0 0.0003911682892906 0.0804477623278618 0.0 5752 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1006363 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0060145792336573 0.662063103571249 0.2491073778594529 0.2461374514707439 0.585843718590581 0.0001990509171164 0.0 0.0003491620111731 0.5747882625296168 0.0 179 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1006511 MMRN2 CD93 MMRN2-CD93 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0060123451723173 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0002165306714062 0.0627790816848129 0.0 0.0 0.0 0.0 271 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1006565 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0060113768744995 0.8840293712888387 0.8347945881127203 0.8567148457705164 0.0061698665784747 0.0012097093680331 0.0 0.002919708029197 0.172803989911201 0.0 137 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1006613 C1QB LRP1 C1QB-LRP1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0060107228551759 0.7753420160918723 0.9078204025796472 0.8567148457705164 0.0012213774841743 0.0064028969591119 0.0 0.0 0.0 0.0 148 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1006942 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0060054483741789 0.8023917560710954 0.7757991160529997 0.7204611100467462 0.0085367158000785 0.0012252690191386 0.0 0.0 0.0 0.0 1538 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1006959 CD48 CD2 CD48-CD2 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0060050764512685 0.7453966474499909 0.6614977577544194 0.6198216015396206 0.006326966401379 0.0024251058581756 0.0 0.0 0.0 0.0 160 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1007140 CD34 SELP CD34-SELP Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0060024812894852 0.7871981482311898 0.7760344326192508 0.6198216015396206 0.0038506427265089 0.0032078747392388 0.0 0.0 0.0 0.0 170 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1007143 VWF ITGA9 VWF-ITGA9 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0060024190200241 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0003457348439318 0.0487643047611538 0.0 0.000670915800067 0.0262615579598998 0.0 271 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1007154 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0060021747530433 0.7797135509308979 0.7283139964676212 0.7204611100467462 0.0009209869688402 0.0124087765732037 0.0 0.0 0.0 0.0 37 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1007222 VWF SELP VWF-SELP CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0060012381243235 0.7158082793127664 0.4623922682986163 0.8767341187813953 0.0071496754272206 0.0022515473538965 0.0 5.559055701738131e-05 0.0053643982138108 0.0 2453 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1007388 DLL4 NOTCH3 DLL4-NOTCH3 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0059990808954065 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0002327631000826 0.0606066271159369 0.0 0.0 0.0 0.0 50 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1007497 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0059975734020157 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0012814156885439 0.0203874717835032 0.0 0.0004409171075837 0.0137738576450936 0.0 126 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1007517 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0059972407765746 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0008320501336843 0.0176963220730796 0.0 0.0003623188405797 0.0479886083480248 0.0 69 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1007645 CD48 CD2 CD48-CD2 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0059953781148122 0.7453966474499909 0.7763428264267787 0.7827641335561659 0.006326966401379 0.0016204239758814 0.0 0.0 0.0 0.0 162 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1007785 C1QB LRP1 C1QB-LRP1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0059931340267518 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.0037630364713574 0.0028784826949613 0.0 0.0 0.0 0.0 50 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1007844 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0059922467914124 0.6303682835571691 0.8891607331132086 0.6198216015396206 0.000219642761279 0.0606680526002441 0.0 0.0005541255541255 0.0183254742223516 0.0 1332 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1007973 COL4A2 CD93 COL4A2-CD93 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.005990462731204 0.9188764516910942 0.4630027772793905 0.2461374514707439 0.0090193130488293 0.0048929293424311 0.0 0.0007604562737642 0.2458883046193638 0.0 263 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1007982 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0059903693277448 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0020251995753771 0.0064028969591119 0.0 8.197393228953193e-05 0.0085458097198432 0.0 1109 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1008040 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0059892761147344 0.8516956437178343 0.7754072541855492 0.6198216015396206 0.000472352586488 0.0238720285974944 0.0 0.0 0.0 0.0 343 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1008100 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0059882609423076 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0186793449598515 0.00071798405859 0.0 3.9382482671707626e-05 0.0208106387481466 0.0 4232 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1008207 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0059866327772704 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0003521782369754 0.0335947364052305 0.0 0.0 0.0 0.0 69 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1008265 CD34 SELP CD34-SELP T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0059857471106563 0.633566764858408 0.8347297932672282 0.6198216015396206 0.015517736049123 0.0009042150166242 0.0 0.0 0.0 0.0 333 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1008266 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0059857450732527 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0007263013575398 0.0203874717835032 0.0 0.0002107279693486 0.0269545167495183 0.0 1305 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1008286 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0059855352399661 0.4648000335061383 0.6207977546603366 0.2461374514707439 0.0357762282281787 0.0018097844702233 0.0 0.0 0.0 0.0 26 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1008345 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0059845884533004 0.7840818683779507 0.836885603004631 0.7827641335561659 0.0032417203409647 0.0027591088867233 0.0 0.0 0.0 0.0 23 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1008454 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0059828715234565 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0051428381563772 0.0049190726392343 0.0 0.0003968253968253 0.0802419327230933 0.0 315 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1008467 COL4A2 CD93 COL4A2-CD93 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0059826445351148 0.7482742921073442 0.6587114738285964 0.6198216015396206 0.005733874009046 0.0026174949623928 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1008518 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.00598183454786 0.7160288858520609 0.4641352222874551 0.2461374514707439 0.0012306151710811 0.0455121851821151 0.0 0.0 0.0 0.0 271 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1008646 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0059798875003476 0.7296454584598743 0.8923034233058523 0.7204611100467462 0.0051524613572059 0.00189193058407 0.0 0.0 0.0 0.0 337 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1008893 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0059762862562418 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0172764782878141 0.0009436211854823 0.0 0.0 0.0 0.0 79 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1009001 COL4A2 CD93 COL4A2-CD93 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0059746948320811 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0316800311254893 0.0003375370073613 0.0 0.0003191489361702 0.2479461469689902 0.0 1880 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1009195 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0059715756114333 0.7745997874735252 0.777821334064334 0.909150863993142 0.0065101973396288 0.001271575589586 0.0 0.0 0.0 0.0 1572 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1009202 VWF LRP1 VWF-LRP1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0059714811398173 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0019871862905238 0.0064028969591119 0.0 0.0008380989942812 0.0873720990500022 0.0 922 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1009221 THBS2 CD36 THBS2-CD36 Endothelial Cells CAFs, Invasive Associated Endothelial Cells -> CAFs, Invasive Associated 0.0059712472843333 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0039472834455595 0.0032616151102094 0.0 0.0001247920133111 0.0395213390530287 0.0 3005 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1009233 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0059710699032084 0.8913986641324685 0.6331674633943454 0.6198216015396206 0.0054950348959687 0.0023576674662702 0.0 0.0002104377104377 0.0653271128399098 0.0 594 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1009376 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0059687998322871 0.9067635403815892 0.2491073778594529 0.2461374514707439 0.0106922602624424 0.0076066460958003 0.0 0.0001173708920187 0.0495352273233842 0.0 1491 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1009387 COL4A1 CD93 COL4A1-CD93 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0059687213214119 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.0017253404164066 0.0118035014556376 0.0 0.0008537279453614 0.0810055608969935 0.0 753 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1009537 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0059661724425781 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0024635726452692 0.0057802287131517 0.0 0.0005108556832694 0.0878873597433468 0.0 1305 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1009575 CD48 CD2 CD48-CD2 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0059656865937107 0.7453966474499909 0.7464347811605867 1.0 0.006326966401379 0.0012805120781881 0.0 0.0013250883392226 0.3216531109634168 0.0 1132 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1009684 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0059639645660543 0.6319926036888139 0.7769451595923457 0.6198216015396206 0.0265972645862203 0.0005558995075445 0.0 0.0015503875968992 0.3475724573297091 0.0 129 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1009775 C3 LRP1 C3-LRP1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0059625603006245 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0042375227960614 0.0267255153180908 0.0 0.0005924170616113 0.0937947130347429 0.0 211 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1009823 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.005961902235048 0.6626993710110988 0.6207977546603366 0.9592803095773328 0.0039530346951707 0.0028784826949613 0.0 8.468834688346883e-05 0.0072031144256605 0.0 1476 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1009844 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0059614811980312 0.8630183004227985 0.8891607331132086 0.8693461273411047 0.0001109003117737 0.0606680526002441 0.0 0.0004629629629629 0.0153106381406099 0.0 360 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1009888 MMRN2 CD93 MMRN2-CD93 T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.005960769098779 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0031934983073077 0.0042738820064046 0.0 0.0002083333333333 0.0265944681554663 0.0 2400 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1009895 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0059605821919687 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0031934983073077 0.0044340558155446 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1009970 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0059594943747621 0.6301823358791634 0.6347970925105053 1.0 0.00146889578236 0.0076236123034427 0.0 9.43930526713234e-05 0.0084122265373179 0.0 5297 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1010057 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0059582158114409 0.4636527906642655 0.8998347793593909 0.7204611100467462 0.0023125636768155 0.0064362797035136 0.0 0.0009891196834817 0.3583808336158872 0.0 337 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1010115 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells T Lymphocytes Dendritic Cells -> T Lymphocytes 0.0059571904690347 0.6301823358791634 0.6347970925105053 0.909150863993142 0.0015409900107563 0.0079745943515326 0.0 0.0001970387884929 0.0236097647595461 0.0 5921 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1010175 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.005956296971265 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.002676946692949 0.0049190726392343 0.0 0.0002370417193426 0.0479321279540601 0.0 791 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1010377 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0059529571809921 0.4619393085577573 0.6331674633943454 0.2461374514707439 0.0835287751665837 0.0007400708115376 0.0 0.0 0.0 0.0 26 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1010407 VWF SELP VWF-SELP Myoepithelial Cells Myoepithelial Cells Myoepithelial Cells -> Myoepithelial Cells 0.0059525107974561 0.7158082793127664 0.4623922682986163 1.0 0.0025256125075084 0.0053213839468185 0.0 2.8458639433103896e-05 0.0130033191162592 0.0 22361 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1010526 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0059506364150013 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0208904415011529 0.000671064546954 0.0 0.0002923976608187 0.0969780847279023 0.0 570 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1010626 CCN1 CAV1 CCN1-CAV1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0059489647325563 0.7324582304061453 0.943345641464811 0.7204611100467462 0.0025580826958339 0.0034806998160403 0.0 0.0002178649237472 0.0806552720576346 0.0 306 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1010640 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0059487142088514 0.8730912658940219 0.7754239189773715 0.7204611100467462 0.0057086106530109 0.0015914585039484 0.0 0.0014854426619132 0.7211677147637455 0.0 306 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1010730 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.00594729377612 0.6659645551150886 0.4603649459881741 0.6198216015396206 0.0037243679732516 0.0062523288579129 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1010749 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0059469124935074 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0021291294377375 0.0064230792457803 0.0 0.0003196022727272 0.042986410468618 0.0 1280 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1010781 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0059464169246458 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0117842887908422 0.001079730675535 0.0 0.0001181474480151 0.0129770008741629 0.0 4232 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1010942 THBS2 CD36 THBS2-CD36 Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0059439353042291 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0039472834455595 0.0031731220372828 0.0 0.0 0.0 0.0 407 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1010960 CD48 CD2 CD48-CD2 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0059436336330602 0.7719609236370527 0.7464347811605867 0.7827641335561659 0.0076331962782219 0.0012805120781881 0.0 0.0 0.0 0.0 316 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1010979 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0059433805583553 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0061207051981986 0.0147571931436988 0.0 0.0013368983957219 0.0267727995817459 0.0 34 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1011009 VWF SELP VWF-SELP CAFs, DCIS Associated CAFs, Invasive Associated CAFs, DCIS Associated -> CAFs, Invasive Associated 0.0059429009804696 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0071496754272206 0.002113171886167 0.0 0.0001630168994185 0.0326353282689803 0.0 1673 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1011148 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0059406867566798 0.6626993710110988 0.2550748532138862 0.2461374514707439 0.0039530346951707 0.0267255153180908 0.0 0.0 0.0 0.0 19 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1011163 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0059403886302403 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0003521782369754 0.0350138403862125 0.0 0.000197628458498 0.0080728854249623 0.0 345 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1011211 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0059395880138894 0.4636527906642655 0.4630488285702799 0.2461374514707439 0.0023125636768155 0.0359289752254096 0.0 0.0006150061500615 0.1551343613948782 0.0 271 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1011246 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.005938995783514 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.000245041593909 0.0501711964086628 0.0 2.562262990673363e-05 0.0005194381535311 0.0 887 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1011527 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0059348772457756 0.6301823358791634 0.6347970925105053 1.0 0.0024635726452692 0.0044340558155446 0.0 0.0002147766323024 0.0280080437966323 0.0 1552 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1011558 A2M LRP1 A2M-LRP1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.00593442909054 0.7741139100414175 0.9078204025796472 0.6198216015396206 0.0015661096645571 0.0064028969591119 0.0 0.0004166666666666 0.0586592680398909 0.0 800 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1011571 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0059341647679322 0.2510234128936706 0.8587566561291643 0.2461374514707439 0.0009262556366009 0.088850508457521 0.0 0.0001876876876876 0.0036655977810212 0.0 222 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1011576 COL4A2 CD93 COL4A2-CD93 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0059340554477473 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0033449520260795 0.0058437228618857 0.0 0.0 0.0 0.0 496 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1011592 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0059338631464451 0.6303682835571691 0.4614667734221426 0.2461374514707439 0.0003788349535045 0.1609352200462838 0.0 0.0021467603434816 0.0450990976942058 0.0 122 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1011787 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0059309374699518 0.8721681415062816 0.7467524951532132 0.7827641335561659 0.0008193633790489 0.0104195741475089 0.0 0.0 0.0 0.0 526 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1011852 VEGFC FLT1 VEGFC-FLT1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0059300072256017 0.8963332422588541 0.6593689120110077 0.6198216015396206 0.0026007495851186 0.0045642085393754 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1011928 MMRN2 CD93 MMRN2-CD93 Dendritic Cells CAFs, DCIS Associated Dendritic Cells -> CAFs, DCIS Associated 0.0059287798737219 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0015409900107563 0.0155837683010033 0.0 0.0003747002398081 0.050958031119121 0.0 3336 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1011963 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0059282539225225 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0117842887908422 0.0007880862995141 0.0 4.3572984749455335e-05 0.0290961827654248 0.0 11475 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1012119 VWF LRP1 VWF-LRP1 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0059256745635412 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.00023686843287 0.0587195251380622 0.0 0.000142580130033 0.0148278740321914 0.0 797 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1012143 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells T Lymphocytes Basal-like Structured DCIS Cells -> T Lymphocytes 0.0059253404328568 0.6242573126045354 0.6176321640000088 0.8693461273411047 0.0020491452254277 0.0063011237754475 0.0 7.246376811594203e-05 0.0146220734589079 0.0 575 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1012340 COL4A2 CD93 COL4A2-CD93 Macrophages B Cells Macrophages -> B Cells 0.0059224133406199 0.9188764516910942 0.7779918296243433 0.6198216015396206 0.0090193130488293 0.001079730675535 0.0 0.0 0.0 0.0 1074 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1012605 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0059179145050831 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.000245041593909 0.0487643047611538 0.0 0.0001024905196269 0.00401177125543 0.0 887 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1012692 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0059165651985064 0.9184503888425788 0.6571792026963191 0.6198216015396206 0.0004696576149175 0.0244129856070659 0.0 0.0 0.0 0.0 390 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1013077 A2M LRP1 A2M-LRP1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0059106387073605 0.4648000335061383 0.9078204025796472 0.7204611100467462 0.0021905373114471 0.0064028969591119 0.0 0.0012254901960784 0.1725272589408558 0.0 306 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1013079 THBS2 CD36 THBS2-CD36 Endothelial Cells Basal-like Structured DCIS Cells Endothelial Cells -> Basal-like Structured DCIS Cells 0.0059105470338952 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0039472834455595 0.0030676679668133 0.0 0.000211398613225 0.1377795406735077 0.0 1971 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1013256 MMRN2 CD93 MMRN2-CD93 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0059078318756807 0.8571898293845529 0.6587114738285964 0.6198216015396206 0.0004196880356983 0.0289462771086338 0.0 0.0 0.0 0.0 78 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1013284 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0059074354336572 0.831981591331937 0.885766439573873 0.8567148457705164 0.0048935684578858 0.0013756087909864 0.0 0.0022522522522522 0.8486282015401699 0.0 148 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1013315 VWF LRP1 VWF-LRP1 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0059069367937363 0.6332974881236617 0.6207977546603366 0.909150863993142 0.00023686843287 0.0501711964086628 0.0 0.0003668055637067 0.0074361143024876 0.0 1549 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1013340 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0059063630866141 0.7475533330314548 0.8381155706134242 0.7827641335561659 0.0029751676683741 0.0029095741067474 0.0 0.0 0.0 0.0 23 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1013347 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0059061190836811 0.4630253981438691 0.7779918296243433 0.2461374514707439 0.0443339118517084 0.001079730675535 0.0 0.0011363636363636 0.1921765241892476 0.0 176 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1013351 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0059060602804692 0.8730912658940219 0.4596166826058663 0.2461374514707439 0.0057086106530109 0.0075270071967493 0.0 0.0008386447500838 0.3702064623130303 0.0 271 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1013453 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0059044719811922 0.7487535481622718 0.7757991160529997 1.0 0.0016417770622885 0.0044430418127202 0.0 0.0064935064935064 0.2427345055020456 0.0 14 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1013469 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0059042186997365 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0028649117803088 0.0042655619249233 0.0 0.0 0.0 0.0 922 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1013487 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.005903989714977 0.4648000335061383 0.6207977546603366 0.2461374514707439 0.0357762282281787 0.0016667952436519 0.0 0.0007102272727272 0.1426190766072234 0.0 176 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1013496 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0059039093753145 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0009692519480124 0.0147571931436988 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1013506 C1QB LRP1 C1QB-LRP1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0059036962078781 0.7753420160918723 0.7769451595923457 0.7827641335561659 0.0161519521398178 0.0005558995075445 0.0 0.0001586294416243 0.0200128392100843 0.0 394 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1013556 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0059029734244455 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0081474500750471 0.0016204239758814 0.0 0.0003673769287288 0.0665963493482724 0.0 1361 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1013574 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0059027833285754 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0016171311116606 0.0083442542366581 0.0 0.0001982750074353 0.0109146231983715 0.0 917 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1013611 CD48 CD2 CD48-CD2 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0059020451057472 0.7453966474499909 0.7763428264267787 0.7827641335561659 0.006326966401379 0.0014748371602574 0.0 0.0 0.0 0.0 23 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1013619 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0059018855575025 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0003521782369754 0.0416128058995347 0.0 0.0001755970299016 0.0072806780083742 0.0 453 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1013666 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0059011491832682 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0012306151710811 0.009971631136135 0.0 0.0 0.0 0.0 271 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1013844 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0058985854196365 0.2451358214448441 0.773263018678637 0.2461374514707439 0.1327555461750915 0.0006800116997025 0.0 0.0105042016806722 0.9025270758122744 0.0 34 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1013874 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0058981001277504 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0186793449598515 0.0004874986369898 0.0 8.714596949891067e-05 0.0546407477307374 0.0 11475 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1013888 C3 LRP1 C3-LRP1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0058978954941408 0.8509500867818902 0.6207977546603366 0.6198216015396206 0.0006305085967044 0.0203874717835032 0.0 0.0 0.0 0.0 30 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1013910 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0058975817339021 0.8718210606749883 0.6593689120110077 0.6198216015396206 0.0017670878089588 0.0066828239855783 0.0 0.0004688232536333 0.0577476145985409 0.0 1422 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1013984 VWF ITGA9 VWF-ITGA9 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0058963650489914 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.00023686843287 0.0565946652887153 0.0 0.0001878287002253 0.0069478345461012 0.0 968 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1014022 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0058958920158425 0.743507317541692 0.6593689120110077 0.6198216015396206 0.0020684923107111 0.0066828239855783 0.0 0.0 0.0 0.0 160 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1014207 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0058929433361756 0.6593525851613742 0.878254460598671 0.6198216015396206 0.0201572483258557 0.0005788283879716 0.0 0.0004916420845624 0.5306166644321509 0.0 339 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1014390 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0058904378682585 0.6303642896310324 0.7841656220878274 0.6198216015396206 0.0104129581710415 0.001309307002134 0.0 0.0003875968992248 0.046358636152 0.0 129 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1014468 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0058893484809909 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0141923232885854 0.0076066460958003 0.0 0.000130548302872 0.0550966236025109 0.0 383 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1014479 THBS2 CD36 THBS2-CD36 Pericytes Plasma Cells Pericytes -> Plasma Cells 0.0058891100202889 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0087456089304998 0.0009761781830445 0.0 0.0 0.0 0.0 394 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1014507 COL4A1 CD93 COL4A1-CD93 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058885674462962 0.9102252263107924 0.6587114738285964 0.6198216015396206 0.0042860632265532 0.0026174949623928 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1014540 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058881290190435 0.6626993710110988 0.6207977546603366 1.0 0.0035190936623492 0.0028784826949613 0.0 8.054123711340206e-05 0.0068503845955379 0.0 1552 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1014591 VWF SELP VWF-SELP Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.005887403747251 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0003457348439318 0.04130664769978 0.0 0.0 0.0 0.0 148 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1014663 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes T Lymphocytes T Lymphocytes -> T Lymphocytes 0.0058863179364487 0.8630183004227985 0.8445107771175474 1.0 0.0006856224272495 0.0083242517891534 0.0 0.0001773479521923 0.020747268643022 0.0 21212 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1014685 VWF ITGA9 VWF-ITGA9 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0058859693130776 0.6332974881236617 0.6252253442669611 0.909150863993142 0.00023686843287 0.0487643047611538 0.0 0.0004695111215446 0.0183780044083482 0.0 1549 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1014796 COL4A1 CD93 COL4A1-CD93 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0058841970264093 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0126216524880575 0.0007261054236978 0.0 0.0 0.0 0.0 81 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1014805 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0058840147914542 0.7451589345683471 0.7167436199046466 0.7204611100467462 0.0040724665904272 0.0026482500471321 0.0 0.0 0.0 0.0 85 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1014913 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0058822430698157 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0308750930304183 0.0007400708115376 0.0 0.0001481042654028 0.0289085627718864 0.0 422 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1014922 MMP2 PECAM1 MMP2-PECAM1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0058820711115892 0.8560892486218385 0.6331674633943454 0.6198216015396206 0.0006966068981631 0.0176963220730796 0.0 0.000801749271137 0.1061905356739091 0.0 343 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1014924 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0058820127018887 0.7719609236370527 0.7763428264267787 0.9429656149619918 0.0014378253178126 0.0050968401714881 0.0 0.0001845018450184 0.0469545921978028 0.0 2710 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1014948 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated CAFs, DCIS Associated CAFs, Invasive Associated -> CAFs, DCIS Associated 0.0058816233441517 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.00146889578236 0.0155837683010033 0.0 0.0003779289493575 0.0513971252648187 0.0 1323 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1014951 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0058815879393211 0.7800321422220979 0.2491073778594529 0.2461374514707439 0.0113788029360913 0.0076066460958003 0.0 8.311170212765957e-05 0.0346249696732096 0.0 752 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1014972 CD34 SELP CD34-SELP Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0058812985347922 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0042829523358709 0.0053213839468185 0.0 0.0 0.0 0.0 1412 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1015003 C1QB LRP1 C1QB-LRP1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0058808993540065 0.7452691992612583 0.9078204025796472 0.7827641335561659 0.0012199377895337 0.0064028969591119 0.0 0.0005929791271347 0.0609590284200413 0.0 527 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1015046 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0058801093583608 0.6342079770588467 0.8341464445360613 0.6198216015396206 0.0673400749834054 0.0001871866311057 0.0 0.0 0.0 0.0 42 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1015049 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0058800672818007 0.8498991475190484 0.7769451595923457 0.6198216015396206 0.018166235813628 0.0005558995075445 0.0 0.0 0.0 0.0 129 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1015070 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0058798080576799 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0037159398684439 0.0058437228618857 0.0 0.0001576789656259 0.0384324217953883 0.0 453 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1015094 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0058795113915552 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0014378253178126 0.0112209532878862 0.0 0.0 0.0 0.0 10961 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1015128 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0058789808574776 0.4636527906642655 0.777821334064334 0.6198216015396206 0.014525360548861 0.001271575589586 0.0 0.0 0.0 0.0 394 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1015175 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0058782357493358 0.7753420160918723 0.9078204025796472 1.0 0.0009153913192522 0.0064028969591119 0.0 7.775566061209257e-05 0.0079933834230808 0.0 4019 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1015209 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0058775620390513 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0172764782878141 0.0007261054236978 0.0 0.0 0.0 0.0 1163 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1015335 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0058756136545471 0.6342079770588467 0.8818120773736414 0.6198216015396206 0.002196330917593 0.0054043611446182 0.0 0.0007347538574577 0.1440639200188326 0.0 1361 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1015339 VWF LRP1 VWF-LRP1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0058755484576276 0.9011206516381156 0.9078204025796472 0.8875000050982297 0.0008850282134344 0.0064028969591119 0.0 8.549931600547196e-05 0.0089133321453802 0.0 1462 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1015464 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0058735923245424 0.7745997874735252 0.878254460598671 0.6198216015396206 0.016822895653248 0.0005788283879716 0.0 0.0 0.0 0.0 1880 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1015504 THBS2 CD36 THBS2-CD36 Myeloid Cells 11q13 Invasive Tumor Cells Myeloid Cells -> 11q13 Invasive Tumor Cells 0.0058729608801644 0.7809827257946271 0.6176321640000088 0.6198216015396206 0.0004779710276932 0.02871400543887 0.0 0.0001444251877527 0.0698895399916136 0.0 1154 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1015517 A2M LRP1 A2M-LRP1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0058727321142803 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.0021905373114471 0.0104714078116759 0.0 0.0004980079681274 0.0683559611755795 0.0 753 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1015555 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0058720794717551 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0016171311116606 0.0642389143033604 0.0 0.0 0.0 0.0 155 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1015559 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058720095928798 0.4629984640915818 0.6207977546603366 0.2461374514707439 0.0201301851612071 0.0028784826949613 0.0 0.0008191837950551 0.060570960517299 0.0 373 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1015653 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0058704073183236 0.255669001367946 0.9008184599638702 0.2461374514707439 0.0002269856810233 0.3180524283074206 0.0 0.0007102272727272 0.0098697543012451 0.0 64 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1015663 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.005870353085488 0.6160088550075702 0.9546923450729716 0.7917001487310438 0.0001971810371238 0.0445745465878424 0.0 0.0 0.0 0.0 38 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1015732 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0058692346765466 0.7941469661104034 0.4614667734221426 0.6198216015396206 0.0083898580598364 0.0021449819680126 0.0 0.0056465273856578 0.204923468711038 0.0 253 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1015932 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058662569775645 0.6630837220165452 0.6587114738285964 0.9592803095773328 0.0037159398684439 0.0026174949623928 0.0 9.67866821525358e-05 0.0094343350944447 0.0 1476 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1015967 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0058657766272598 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0015572459193676 0.0083442542366581 0.0 0.0 0.0 0.0 42 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1016138 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0058633011258863 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0244483651952677 0.0009249287638231 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1016182 THBS2 CD36 THBS2-CD36 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0058624454606702 0.7809827257946271 0.6176321640000088 0.6198216015396206 0.0004779710276932 0.0284069116891947 0.0 0.0012254901960784 0.1015127216688159 0.0 170 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1016280 VWF LRP1 VWF-LRP1 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0058609186619861 0.8525936146535493 0.6207977546603366 0.6198216015396206 0.0002103933337194 0.0587195251380622 0.0 0.0001456876456876 0.0151510456457135 0.0 78 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1016367 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0058595717587618 0.4604235282221027 0.6587114738285964 0.2461374514707439 0.0126864732057784 0.0042738820064046 0.0 0.0 0.0 0.0 147 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1016392 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.005859269075856 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0016417770622885 0.0080072638027924 0.0 0.0006313131313131 0.1524942272846553 0.0 144 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1016438 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0058586305449262 0.6342079770588467 0.7480927101953669 0.6198216015396206 0.002196330917593 0.006260692484444 0.0 0.0 0.0 0.0 143 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1016612 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.005855806117169 0.6301823358791634 0.6347970925105053 0.8693461273411047 0.0172764782878141 0.000671064546954 0.0 0.0 0.0 0.0 270 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1016661 C3 LRP1 C3-LRP1 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0058549227649501 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0064915662046245 0.0018097844702233 0.0 8.012820512820513e-05 0.0282956743630901 0.0 312 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1016713 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0058541843808672 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0024635726452692 0.0058465532256424 0.0 0.0002334267040149 0.0491286789699831 0.0 714 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1016894 CCN1 CAV1 CCN1-CAV1 B Cells Macrophages B Cells -> Macrophages 0.0058515101843988 0.6213271600240247 0.8818704453527788 0.6198216015396206 0.0023088899408624 0.0051192928876727 0.0 9.389671361502347e-05 0.0176896450245883 0.0 1065 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1017041 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0058491035315295 0.6301823358791634 0.6587114738285964 0.9161861017439124 0.0024635726452692 0.0042738820064046 0.0 0.0016375545851528 0.2090394876848881 0.0 458 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1017094 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058481960273252 0.8516956437178343 0.6571792026963191 0.6198216015396206 0.000472352586488 0.0244129856070659 0.0 0.0 0.0 0.0 10 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1017123 VWF SELP VWF-SELP Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0058478369141583 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0003457348439318 0.0335947364052305 0.0 0.0001810938065918 0.0096876330308159 0.0 753 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1017209 C3 LRP1 C3-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058464024266972 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.005043231651446 0.0028784826949613 0.0 0.0003793626707132 0.0981522663756957 0.0 659 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1017267 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0058455158758829 0.250044481781731 0.4630027772793905 1.0 0.0070431301838115 0.0048929293424311 0.0 0.0001193625395186 0.0245481279360888 0.0 77495 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1017289 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.005845238237283 0.6301823358791634 0.8514619504364779 0.6198216015396206 0.0208904415011529 0.0005740632036187 0.0 0.0039682539682539 0.6859337845253339 0.0 42 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1017379 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0058437083115153 0.8818165186409654 0.7346293219749174 0.7204611100467462 0.0026436039558049 0.0032275631628407 0.0 0.0003898635477582 0.021436502036279 0.0 285 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1017409 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0058432966488897 0.250044481781731 0.7779918296243433 0.2461374514707439 0.0070431301838115 0.0118035014556376 0.0 0.0 0.0 0.0 316 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1017429 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.005842963989207 0.4636527906642655 0.7472387841445823 0.7204611100467462 0.0023125636768155 0.0068935067166085 0.0 0.0 0.0 0.0 43 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1017460 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0058426040291115 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0033537993821664 0.0309945332907452 0.0 0.0005753739930955 0.035891185835381 0.0 316 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1017485 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0058420725008357 0.7745997874735252 0.8331580262014722 0.6198216015396206 0.0065101973396288 0.001526625481682 0.0 0.0 0.0 0.0 151 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1017573 VEGFC FLT1 VEGFC-FLT1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0058408573125841 0.8317042416754105 0.777821334064334 0.6198216015396206 0.0005440770361181 0.0182001711419816 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1017746 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058378909593471 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.0047694898966413 0.0026174949623928 0.0 0.0001831501831501 0.0178526648710262 0.0 390 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1017764 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0058377235095445 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0053032910137447 0.0040904475843412 0.0 0.0 0.0 0.0 79 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1017845 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0058363687375537 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.002196330917593 0.0046263543438723 0.0 7.246376811594203e-05 0.0395021835861632 0.0 2300 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1017846 VEGFC FLT1 VEGFC-FLT1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0058363395018579 0.7745997874735252 0.4630488285702799 0.2461374514707439 0.0012459853895406 0.0359289752254096 0.0 0.0007898894154818 0.1992483978104834 0.0 211 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1017867 VWF LRP1 VWF-LRP1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0058360199707139 0.8525936146535493 0.7346293219749174 0.7204611100467462 0.0002103933337194 0.0416128058995347 0.0 0.0001721763085399 0.0071388466186006 0.0 66 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1017888 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.005835769777102 0.4593282471594782 0.7763428264267787 0.2461374514707439 0.0181222899145132 0.0024832440877005 0.0 0.0002880184331797 0.0736304884932774 0.0 1736 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1017917 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.005835265264115 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0015572459193676 0.0642389143033604 0.0 0.0002590002590002 0.0121222112237126 0.0 351 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1018077 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.005832496148808 0.8913986641324685 0.7841656220878274 0.7827641335561659 0.0054950348959687 0.001309307002134 0.0 0.0 0.0 0.0 179 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1018095 C3 LRP1 C3-LRP1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0058322933307068 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0042375227960614 0.0032275631628407 0.0 0.0011784511784511 0.1092612206233985 0.0 297 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1018100 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0058322057926402 0.7800321422220979 0.930308383061206 0.6198216015396206 0.0213929720256037 0.0004089864655001 0.0 3.324468085106383e-05 0.0427296851758216 0.0 1880 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1018112 VWF ITGA9 VWF-ITGA9 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.005831929442454 0.8525936146535493 0.6252253442669611 0.6198216015396206 0.0002103933337194 0.0565946652887153 0.0 0.0 0.0 0.0 144 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1018148 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0058312358942902 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0072827533047186 0.0016667952436519 0.0 0.0003306878306878 0.0418369599028177 0.0 42 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1018331 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0058281920005117 0.6303642896310324 0.7841656220878274 0.6198216015396206 0.0097699360831605 0.001309307002134 0.0 0.0001322751322751 0.0158208044010793 0.0 756 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1018334 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0058281492696761 0.7468485855611411 0.6207977546603366 0.6198216015396206 0.0006689050756654 0.0203874717835032 0.0 0.0018004115226337 0.0562432520507989 0.0 162 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1018353 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0058276825489993 0.4630253981438691 0.7461459456652184 0.2461374514707439 0.0443339118517084 0.0010390313650636 0.0 0.0 0.0 0.0 84 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1018405 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0058266649082942 0.6626993710110988 0.2550748532138862 0.2461374514707439 0.0035190936623492 0.0267255153180908 0.0 0.0007122507122507 0.0443086267282744 0.0 351 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1018426 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0058263644464766 0.250044481781731 0.9003264838243337 0.2461374514707439 7.058774627838557e-05 1.0 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1018431 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0058262795257938 0.8818165186409654 0.2550748532138862 0.2461374514707439 0.0026436039558049 0.0267255153180908 0.0 0.0005961696102541 0.0356374514624238 0.0 1491 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1018444 MMRN2 CD93 MMRN2-CD93 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0058260664109555 0.893316592628645 0.7779918296243433 0.6198216015396206 0.0007691101630988 0.0118035014556376 0.0 0.0 0.0 0.0 3576 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1018462 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.005825837919503 0.4619393085577573 0.930308383061206 0.7204611100467462 0.0308750930304183 0.0004089864655001 0.0 0.0001625487646293 0.2089253787530423 0.0 1538 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1018526 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0058248739467014 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0015847932820241 0.0080072638027924 0.0 0.0005681818181818 0.1372448045561897 0.0 160 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1018541 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0058245958864068 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0186793449598515 0.0006074333625108 0.0 0.0 0.0 0.0 4232 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1018632 C1QB LRP1 C1QB-LRP1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0058230409215642 0.7753420160918723 0.8755243548400705 0.8567148457705164 0.0161519521398178 0.0004150165744076 0.0 0.0008333333333333 0.1031459194952619 0.0 225 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1018744 THBS2 CD36 THBS2-CD36 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0058212533454522 0.9197297916541942 0.7763054211764489 0.7827641335561659 0.0039472834455595 0.0017638974017382 0.0 0.0007402707275803 0.1063089780349893 0.0 394 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1018764 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0058209685261202 0.6332974881236617 0.8347297932672282 0.6198216015396206 0.0131302879503246 0.0009042150166242 0.0 0.0 0.0 0.0 42 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1018766 CCN1 CAV1 CCN1-CAV1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0058209216968418 0.8619922139338987 0.7832252605020791 0.7827641335561659 0.0054092055025683 0.00136079311934 0.0 0.0 0.0 0.0 179 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1018767 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0058209214755976 0.4604235282221027 0.4630027772793905 0.2461374514707439 0.0126864732057784 0.0058437228618857 0.0 0.0001496781918874 0.0364823258533681 0.0 13362 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1019026 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058170287768406 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0051428381563772 0.0041555861088636 0.0 0.0 0.0 0.0 3 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1019038 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0058167304012312 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0168149984327668 0.0009242223287825 0.0 0.0008965929468021 0.1729516820258477 0.0 239 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1019093 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0058157797939644 0.7205550478301406 0.4630027772793905 0.8293805866303694 0.0151307911035231 0.0009242223287825 0.0 0.0 0.0 0.0 219 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1019103 MMP2 PECAM1 MMP2-PECAM1 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0058155840574638 0.8560892486218385 0.7167436199046466 0.7204611100467462 0.0006966068981631 0.0125623889131764 0.0 0.0005283381364073 0.1701925126134185 0.0 1041 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1019149 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0058148912337694 0.4636527906642655 0.878254460598671 0.2461374514707439 0.0666348171285698 0.0005788283879716 0.0 0.0 0.0 0.0 1384 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1019260 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0058132970560315 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0106340017102282 0.0012252690191386 0.0 3.7257824143070045e-05 0.0298946309527806 0.0 4880 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1019382 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0058112426629304 0.6213271600240247 0.7832252605020791 0.6198216015396206 0.0093830613230477 0.00136079311934 0.0 0.0028985507246376 0.4260896589931494 0.0 23 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1019385 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0058111940690168 0.8624864526942296 0.7746834992804791 0.6198216015396206 0.0020100505037262 0.0046263543438723 0.0 0.0002429543245869 0.0854667580574484 0.0 343 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1019394 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0058110789247852 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0081474500750471 0.0014748371602574 0.0 0.0076923076923076 0.1267057854698742 0.0 130 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1019407 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0058108976687703 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0039530346951707 0.0032275631628407 0.0 0.025 0.9962868450407224 0.0 5 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1019521 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells 0.0058091834165249 0.6242573126045354 0.6176321640000088 0.8824495942126559 0.000393370777602 0.02871400543887 0.0 6.886483210753932e-06 0.0033324737273912 0.0 12101 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1019535 COL4A2 CD93 COL4A2-CD93 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0058089450137136 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0267593032157803 0.0003375370073613 0.0 0.0004338394793926 0.3370489922644263 0.0 922 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1019556 VWF LRP1 VWF-LRP1 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0058085915766563 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0036144684673052 0.0267255153180908 0.0 0.0002076904818419 0.011357771943102 0.0 383 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1019573 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.005808250806134 0.7205550478301406 0.8514619504364779 0.7204611100467462 0.0151307911035231 0.0005740632036187 0.0 0.0 0.0 0.0 38 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1019598 DLL1 NOTCH3 DLL1-NOTCH3 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.005807901893041 0.6249837837987587 0.8818326005152037 0.6198216015396206 0.00263399584678 0.0042655619249233 0.0 0.0 0.0 0.0 800 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1019606 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0058078017151222 0.6589792304505506 0.6207977546603366 0.9592803095773328 0.0033973231723341 0.0028784826949613 0.0 0.0004422613670581 0.0327010812031525 0.0 1476 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1019661 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells CAFs, Invasive Associated 11q13 Invasive Tumor Cells -> CAFs, Invasive Associated 0.005807180136023 0.6242573126045354 0.6176321640000088 0.8824495942126559 0.0034559943126159 0.0032616151102094 0.0 5.352172982230786e-05 0.0169502067871764 0.0 4671 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1019680 MMP2 PECAM1 MMP2-PECAM1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.005806962153705 0.9330801352629944 0.2491073778594529 0.2461374514707439 0.0088108219576754 0.0076066460958003 0.0 0.0003802281368821 0.1604715349031308 0.0 263 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1019692 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0058067072282577 0.7451589345683471 0.6331674633943454 0.6198216015396206 0.0040724665904272 0.0032187363284526 0.0 0.0 0.0 0.0 160 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1019723 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0058061193881684 0.250044481781731 0.8817184225858201 0.2461374514707439 7.058774627838557e-05 1.0 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1019804 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0058050387216928 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0012306151710811 0.0090444648829713 0.0 0.0 0.0 0.0 271 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1019830 VWF SELP VWF-SELP CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.005804518464457 0.9275752708651288 0.6572093097629401 0.6198216015396206 0.000245041593909 0.04130664769978 0.0 0.0 0.0 0.0 5683 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1019931 COL4A2 CD93 COL4A2-CD93 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0058025421736032 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.0047240947268779 0.0042738820064046 0.0 0.0 0.0 0.0 285 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1019947 C1QB LRP1 C1QB-LRP1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0058022288791052 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0012213774841743 0.0104714078116759 0.0 0.0014577259475218 0.1457956056700565 0.0 343 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1020029 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0058007621640986 0.255669001367946 0.4600037439857229 0.2461374514707439 0.0061207051981986 0.0215025911544899 0.0 0.0002313208420078 0.0277898852237883 0.0 13362 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1020093 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0057996044069539 0.7941469661104034 0.8445107771175474 0.7917001487310438 0.0083898580598364 0.0008542071298387 0.0 0.0006750791919821 0.1246833870285682 0.0 917 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1020099 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0057994850102865 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0117842887908422 0.0011388334136451 0.0 0.0 0.0 0.0 135 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1020191 CD34 SELP CD34-SELP Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0057982377262576 0.8963354148873306 0.4623922682986163 0.2461374514707439 0.0038492365148421 0.0096770075292062 0.0 0.0 0.0 0.0 263 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1020282 VWF ITGA9 VWF-ITGA9 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0057966784450257 0.7848266128497919 0.6252253442669611 0.6198216015396206 0.0004024409845247 0.0309945332907452 0.0 0.0 0.0 0.0 388 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1020327 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Dendritic Cells T Lymphocytes -> Dendritic Cells 0.0057958625111722 0.6301823358791634 0.6347970925105053 0.909150863993142 0.0031934983073077 0.003263637675389 0.0 0.0002602359472588 0.0262248589346368 0.0 5764 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1020338 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0057956674722125 0.2451358214448441 0.4614667734221426 0.2461374514707439 0.0010709508378277 0.12709315903692 0.0 0.0090957731407169 0.4284922585742555 0.0 89 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1020346 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0057954675421011 0.6561647292424944 0.6207977546603366 0.7917001487310438 0.0070489045197697 0.0016667952436519 0.0 0.0 0.0 0.0 38 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1020350 C3 LRP1 C3-LRP1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0057954012997254 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0042375227960614 0.0028784826949613 0.0 0.0 0.0 0.0 50 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1020405 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0057946427499666 0.6319926036888139 0.8755243548400705 0.6198216015396206 0.0265972645862203 0.0004150165744076 0.0 0.0 0.0 0.0 18 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1020616 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0057911908603446 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.002676946692949 0.0041555861088636 0.0 0.0003205128205128 0.0407049053230409 0.0 390 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1020656 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0057905046167667 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0161193721503025 0.0007400708115376 0.0 0.0003588516746411 0.0826987646253561 0.0 209 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1020671 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.005790259648113 0.8949858186325867 0.7746834992804791 0.6198216015396206 0.001895566065636 0.0046263543438723 0.0 0.0002330350484712 0.1270344270807823 0.0 3576 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1020688 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0057898679325662 0.6593525851613742 0.878254460598671 0.6198216015396206 0.018132161410931 0.0005788283879716 0.0 0.0002237136465324 0.2414483882449653 0.0 1490 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1020857 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0057871346047276 0.6589792304505506 0.2550748532138862 0.2461374514707439 0.0033973231723341 0.0267255153180908 0.0 0.0 0.0 0.0 19 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1021109 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.005782884194688 0.4619393085577573 0.7167436199046466 0.8293805866303694 0.0051428381563772 0.0026482500471321 0.0 0.0 0.0 0.0 324 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1021235 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0057807192996137 0.2486570577556728 0.4623922682986163 1.0 0.0033537993821664 0.0096770075292062 0.0 4.985658898814584e-05 0.0142231234042141 0.0 77495 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1021242 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0057806185851804 0.6242573126045354 0.6176321640000088 0.8824495942126559 0.0034559943126159 0.0031731220372828 0.0 3.83638849362462e-05 0.0171981455430574 0.0 11947 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1021290 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Endothelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Endothelial Cells 0.00577995523399 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0007263013575398 0.0144359394371152 0.0 0.0002027027027027 0.0346164922916092 0.0 370 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1021365 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0057787887447209 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0001971810371238 0.1076178292491983 0.0 0.0 0.0 0.0 77 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1021403 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0057779128328311 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0015409900107563 0.0076236123034427 0.0 0.0 0.0 0.0 2359 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1021449 CCN1 CAV1 CCN1-CAV1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0057770410882421 0.2542249848376565 0.62431395375366 0.2461374514707439 0.0014656941948563 0.0649213179279442 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1021576 C3 LRP1 C3-LRP1 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0057751566736153 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0064915662046245 0.0016667952436519 0.0 0.0002997179125528 0.0550492683655153 0.0 1418 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1021578 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated T Lymphocytes CAFs, Invasive Associated -> T Lymphocytes 0.0057751175831914 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.00146889578236 0.0079745943515326 0.0 0.0001449275362318 0.0173656418809034 0.0 2300 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1021738 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0057721879590088 0.940547666092272 0.7779918296243433 0.6198216015396206 0.0001298888146421 0.0627790816848129 0.0 0.0005636978579481 0.0123439468600765 0.0 887 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1021860 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0057703827600567 0.6582846571368821 0.7779918296243433 0.7917001487310438 0.0084325366891025 0.001079730675535 0.0 0.0 0.0 0.0 38 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1021882 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0057700703388807 0.662063103571249 0.930308383061206 0.6198216015396206 0.0236359933700329 0.0004089864655001 0.0 0.0 0.0 0.0 380 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1021894 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0057698774635216 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0016171311116606 0.0064028969591119 0.0 6.1012812690665054e-05 0.0063606060263799 0.0 1490 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1021898 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0057697552008765 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.0037268694422441 0.0028784826949613 0.0 0.0001068376068376 0.0172696932584323 0.0 390 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1021905 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.005769680264027 0.9067635403815892 0.930308383061206 1.0 0.0106922602624424 0.0004089864655001 0.0 7.464543418760887e-05 0.1355875832177936 0.0 4019 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1022154 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0057659030520984 0.2542249848376565 0.62431395375366 0.2461374514707439 0.0014656941948563 0.0641739251983978 0.0 0.0007309941520467 0.0694409168110582 0.0 684 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1022173 VWF SELP VWF-SELP CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0057655086694562 0.9275752708651288 0.7760344326192508 0.6198216015396206 0.000245041593909 0.0335947364052305 0.0 0.0001449905756125 0.0077562867328064 0.0 1881 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1022346 C1QB LRP1 C1QB-LRP1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0057629669437455 0.7452691992612583 0.6207977546603366 0.6198216015396206 0.0012199377895337 0.0104714078116759 0.0 0.000805412371134 0.0805539509420576 0.0 388 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1022355 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0057628633779348 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0003788349535045 0.0373075519081129 0.0 0.0 0.0 0.0 30 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1022400 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0057622381384356 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0009692519480124 0.0215025911544899 0.0 0.0001909854851031 0.0229441699431697 0.0 714 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1022510 CCN1 CAV1 CCN1-CAV1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0057607851839882 0.2542249848376565 0.62431395375366 0.2461374514707439 0.0014656941948563 0.0638329144736252 0.0 0.0 0.0 0.0 184 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1022525 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0057605852972718 0.7800321422220979 0.8537710813834968 0.6198216015396206 0.0213929720256037 0.0004138063814779 0.0 0.0007507507507507 0.065599580162687 0.0 333 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1022540 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0057602775891313 0.6332974881236617 0.7760344326192508 1.0 0.0020251995753771 0.0036702914086929 0.0 1.857562135453431e-05 0.0077478891782297 0.0 19576 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1022682 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0057582640371884 0.6659645551150886 0.6614977577544194 0.9161861017439124 0.0037243679732516 0.0024251058581756 0.0 0.0 0.0 0.0 408 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1022700 VWF SELP VWF-SELP B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0057580335473746 0.6332974881236617 0.7760344326192508 0.9318789094584046 0.00023686843287 0.0335947364052305 0.0 5.470958329534056e-05 0.0029266951543448 0.0 4985 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1022920 HSPG2 LRP1 HSPG2-LRP1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0057546726627293 0.7789175740361626 0.9078204025796472 0.6198216015396206 0.0012941512528773 0.0064028969591119 0.0 0.0003125 0.036978649981115 0.0 800 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1022939 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0057542956227176 0.4619393085577573 0.8537710813834968 0.7204611100467462 0.0308750930304183 0.0004138063814779 0.0 0.0 0.0 0.0 38 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1023215 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0057498637138417 0.4619393085577573 0.930308383061206 0.2461374514707439 0.0835287751665837 0.0004089864655001 0.0 0.0002257947976878 0.2902160698357831 0.0 1384 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1023241 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.005749289392491 0.6249837837987587 0.7470475610360806 0.6198216015396206 0.0161757332769496 0.0007714919761827 0.0 0.0005175983436853 0.0794771452777666 0.0 161 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1023652 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.005742447351625 0.4601010570874773 0.6207977546603366 0.2461374514707439 0.0177188549930425 0.0028784826949613 0.0 0.0003351206434316 0.028503476922989 0.0 373 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1023665 CCN1 CAV1 CCN1-CAV1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0057422709468947 0.8619922139338987 0.8617632615906476 0.8567148457705164 0.0054092055025683 0.0010414441948928 0.0 0.0 0.0 0.0 165 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1023880 MMRN2 CD93 MMRN2-CD93 Macrophages CAFs, DCIS Associated Macrophages -> CAFs, DCIS Associated 0.0057386678172806 0.893316592628645 0.4630027772793905 0.7204611100467462 0.0007691101630988 0.0155837683010033 0.0 0.000102522042239 0.0139426690025333 0.0 9754 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1023991 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0057366052004293 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0071496754272206 0.0018097844702233 0.0 0.0005892255892255 0.0612113420743316 0.0 135 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1024085 C3 LRP1 C3-LRP1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.005735149018263 0.9487258305485792 0.7769451595923457 0.7827641335561659 0.0110943464444434 0.0005558995075445 0.0 0.0 0.0 0.0 179 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1024136 VWF LRP1 VWF-LRP1 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0057342580414308 0.7158082793127664 0.7346293219749174 0.8293805866303694 0.0025256125075084 0.0032275631628407 0.0 0.0004669987546699 0.0222294712238985 0.0 219 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1024157 COL4A2 CD93 COL4A2-CD93 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0057339257869881 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0033449520260795 0.0026174949623928 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1024174 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0057337039975421 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0015572459193676 0.0064028969591119 0.0 0.0002011263073209 0.0209674844674914 0.0 339 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1024180 EFNB2 PECAM1 EFNB2-PECAM1 B Cells B Cells B Cells -> B Cells 0.0057335830895432 0.7800321422220979 0.6331674633943454 1.0 0.0014623066995027 0.0049190726392343 0.0 8.815232722143864e-05 0.0178252530379227 0.0 1418 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1024430 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0057296441967241 0.6160088550075702 0.6632137581773894 0.8824495942126559 0.0001971810371238 0.049767778498468 0.0 4.8875855327468224e-05 0.016703102308251 0.0 12090 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1024493 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0057283531455889 0.6301823358791634 0.7779918296243433 0.8693461273411047 0.0015409900107563 0.0053794918117879 0.0 0.0002008032128514 0.0242393850714147 0.0 1245 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1024645 CCN1 CAV1 CCN1-CAV1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.00572576822343 0.7797135509308979 0.62431395375366 0.6198216015396206 0.0009209869688402 0.0126805820762719 0.0 8.591065292096219e-05 0.0175021979477273 0.0 388 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1024721 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0057245865554973 0.6342079770588467 0.8923034233058523 0.6198216015396206 0.0053032910137447 0.00189193058407 0.0 0.0 0.0 0.0 475 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1024725 C3 LRP1 C3-LRP1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0057245261218585 0.7148920381722296 0.2550748532138862 0.2461374514707439 0.0029337538459309 0.0267255153180908 0.0 0.0006457564575645 0.1022396982673914 0.0 271 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1024955 VEGFC FLT1 VEGFC-FLT1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0057206440980137 0.8317042416754105 0.4630488285702799 0.7204611100467462 0.0005440770361181 0.0232163927704059 0.0 0.0 0.0 0.0 66 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1024995 HSPG2 LRP1 HSPG2-LRP1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0057201326037245 0.9253089325030373 0.7346293219749174 0.7204611100467462 0.0022161183602947 0.0032275631628407 0.0 0.0002130197682344 0.0117128126540251 0.0 326 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1025179 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0057170798212228 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0208904415011529 0.0009242223287825 0.0 0.0 0.0 0.0 103 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1025197 VWF SELP VWF-SELP T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.005716883632516 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0036144684673052 0.0053213839468185 0.0 0.0 0.0 0.0 1278 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1025206 VWF ITGA9 VWF-ITGA9 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0057166929356696 0.9011206516381156 0.6252253442669611 0.6198216015396206 0.0008850282134344 0.0112932915661816 0.0 0.0 0.0 0.0 129 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1025242 VWF LRP1 VWF-LRP1 B Cells Macrophages B Cells -> Macrophages 0.0057160924166232 0.6332974881236617 0.8604147465201248 0.6198216015396206 0.00023686843287 0.0436001007095475 0.0 7.469056764831413e-05 0.0014247810662124 0.0 1065 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1025339 CCN1 CAV1 CCN1-CAV1 Macrophages B Cells Macrophages -> B Cells 0.0057147085205237 0.8619922139338987 0.62431395375366 0.6198216015396206 0.0054092055025683 0.0019304335593669 0.0 0.0 0.0 0.0 1074 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1025389 JAG1 NOTCH2 JAG1-NOTCH2 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0057137366242606 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0001109003117737 0.12709315903692 0.0 0.0002912836286949 0.0137220638657395 0.0 4087 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1025407 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.005713342161131 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.000895875398841 0.009971631136135 0.0 0.0 0.0 0.0 193 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1025412 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0057132581818026 0.633566764858408 0.6572093097629401 0.9592803095773328 0.0083565457974945 0.0010419094417808 0.0 0.0 0.0 0.0 1495 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1025419 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0057131273780094 0.8498991475190484 0.8755243548400705 0.6198216015396206 0.018166235813628 0.0004150165744076 0.0 0.0 0.0 0.0 18 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1025432 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0057129560139446 0.7840818683779507 0.4641352222874551 0.7204611100467462 0.0032417203409647 0.0040904475843412 0.0 0.0 0.0 0.0 37 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1025467 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0057123820458375 0.6582846571368821 0.8347945881127203 0.6198216015396206 0.0084325366891025 0.0012097093680331 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1025646 VEGFC FLT1 VEGFC-FLT1 B Cells Macrophages B Cells -> Macrophages 0.0057096543197341 0.7745997874735252 0.8998347793593909 0.6198216015396206 0.0012459853895406 0.0064362797035136 0.0 0.0 0.0 0.0 1065 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1025672 VWF LRP1 VWF-LRP1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0057092318970539 0.8525936146535493 0.6207977546603366 0.6198216015396206 0.0002103933337194 0.0501711964086628 0.0 0.0010521885521885 0.0213306315825061 0.0 162 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1025776 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0057076925399071 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.0198024073017111 0.0009242223287825 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1025787 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0057075195241666 0.8721681415062816 0.4642836810638544 0.7204611100467462 0.0008193633790489 0.0144613249009303 0.0 0.0011695906432748 0.0067780526654692 0.0 285 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1025799 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0057072839045588 0.6332974881236617 0.7831795333113832 0.6198216015396206 0.0020251995753771 0.0055509879377996 0.0 0.0 0.0 0.0 129 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1025893 A2M LRP1 A2M-LRP1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0057056001945156 0.7460047258226694 0.9078204025796472 0.7827641335561659 0.0010163752993685 0.0064028969591119 0.0 0.0001581277672359 0.0222615817988201 0.0 527 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1026044 HSPG2 LRP1 HSPG2-LRP1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0057030723809799 0.9253089325030373 0.2550748532138862 0.2461374514707439 0.0022161183602947 0.0267255153180908 0.0 0.0001056189269117 0.0063136216885068 0.0 263 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1026053 CD34 SELP CD34-SELP Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0057029944527378 0.633566764858408 0.7478729882108823 0.6198216015396206 0.0042829523358709 0.0027351735586246 0.0 0.0 0.0 0.0 161 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1026138 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0057013876672386 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0049987108499989 0.0176963220730796 0.0 7.911392405063291e-05 0.0104785252405497 0.0 316 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1026249 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0056995707976714 0.6213271600240247 0.7832252605020791 0.6198216015396206 0.0083518627398662 0.00136079311934 0.0 0.0002070393374741 0.0304349756423678 0.0 161 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1026263 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0056993669114504 0.6626993710110988 0.7346293219749174 0.6198216015396206 0.0035190936623492 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1026278 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0056992128776261 0.662063103571249 0.8537710813834968 0.6198216015396206 0.0236359933700329 0.0004138063814779 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1026363 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.005698107663604 0.6160088550075702 0.9460955677032749 0.7917001487310438 0.0001971810371238 0.0376195773145198 0.0 0.0 0.0 0.0 38 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1026379 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0056978480361051 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0003521782369754 0.0309945332907452 0.0 0.0 0.0 0.0 69 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1026465 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0056963500418357 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0083565457974945 0.0022515473538965 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1026523 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0056954880394023 0.8730912658940219 0.7757991160529997 0.7204611100467462 0.0057086106530109 0.0012252690191386 0.0 0.0001485442661913 0.1191877443215439 0.0 306 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1026556 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0056948453246491 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.000393370777602 0.0284069116891947 0.0 0.0 0.0 0.0 209 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1026641 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0056935826683479 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0002165306714062 0.0554888093272979 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1026692 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0056926802707861 0.2490567623945399 0.8818120773736414 0.2461374514707439 0.011649387573427 0.0054043611446182 0.0 0.0 0.0 0.0 222 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1026731 A2M LRP1 A2M-LRP1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0056918668359379 0.8392912392980421 0.6207977546603366 0.6198216015396206 0.0005164482812395 0.0203874717835032 0.0 0.0 0.0 0.0 30 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1026811 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0056903808284279 0.6160088550075702 0.7462743270426613 0.6198216015396206 0.0052742025956585 0.0022591041672132 0.0 0.0013271400132714 0.1474699049795191 0.0 137 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1026865 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.005689413342406 0.7482742921073442 0.8347945881127203 0.7827641335561659 0.005733874009046 0.0012097093680331 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1026872 VWF ITGA9 VWF-ITGA9 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0056892883111243 0.6332974881236617 0.7831795333113832 0.6198216015396206 0.0019871862905238 0.0055509879377996 0.0 0.0005646527385657 0.0421099485238067 0.0 161 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1026890 VWF ITGA9 VWF-ITGA9 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0056889661969868 0.8525936146535493 0.6252253442669611 0.6198216015396206 0.0002103933337194 0.0487643047611538 0.0 0.0 0.0 0.0 162 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1026905 C1QB LRP1 C1QB-LRP1 B Cells B Cells B Cells -> B Cells 0.0056887103723407 0.8703788833238396 0.6207977546603366 1.0 0.0037630364713574 0.0016667952436519 0.0 8.815232722143864e-05 0.0154950550312836 0.0 1418 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1026934 CD34 SELP CD34-SELP Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0056882801695207 0.633566764858408 0.941479368642921 0.6198216015396206 0.0042829523358709 0.0021392900294222 0.0 0.0003061849357011 0.0990450349629388 0.0 1633 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1027035 THBS2 CD36 THBS2-CD36 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0056863949620053 0.8858959974474152 0.6176321640000088 0.6198216015396206 0.0030563796158022 0.0032616151102094 0.0 0.0003385032003938 0.1072031726897969 0.0 1354 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1027147 COL4A1 CD93 COL4A1-CD93 Macrophages Mast Cells Macrophages -> Mast Cells 0.0056848390072226 0.9102252263107924 0.8347945881127203 0.8567148457705164 0.0042860632265532 0.0012097093680331 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1027155 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0056847811217043 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0024319941937022 0.0049190726392343 0.0 0.0037301587301587 0.455643488106714 0.0 315 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1027156 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Myoepithelial Cells T Lymphocytes -> Myoepithelial Cells 0.0056847646944853 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0031934983073077 0.0058437228618857 0.0 0.0 0.0 0.0 1278 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1027285 VEGFC FLT1 VEGFC-FLT1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0056825153226377 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0012459853895406 0.0066828239855783 0.0 0.0005165289256198 0.0636237923237024 0.0 968 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1027324 VWF LRP1 VWF-LRP1 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0056816884367247 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0036144684673052 0.0032275631628407 0.0 0.0003825066938671 0.0182075893334597 0.0 713 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1027329 VWF SELP VWF-SELP Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0056815657489739 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0025256125075084 0.0045674276780054 0.0 6.897503103876398e-05 0.0116090517456192 0.0 659 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1027331 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0056815578388817 0.633566764858408 0.6572093097629401 0.9592803095773328 0.0018436902762588 0.0045674276780054 0.0 0.0 0.0 0.0 1476 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1027420 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0056802163888419 0.7840818683779507 0.8923034233058523 0.7827641335561659 0.0032417203409647 0.00189193058407 0.0 0.0 0.0 0.0 162 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1027425 THBS2 CD36 THBS2-CD36 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0056801136715219 0.6242573126045354 0.7763054211764489 0.6198216015396206 0.0063387366560491 0.0017638974017382 0.0 0.000230840258541 0.0331505637877212 0.0 361 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1027453 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Mast Cells Macrophages -> Mast Cells 0.0056794336659808 0.8949858186325867 0.836885603004631 0.8567148457705164 0.001895566065636 0.0027591088867233 0.0 0.0 0.0 0.0 165 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1027464 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0056792543934357 0.4619393085577573 0.8537710813834968 0.2461374514707439 0.0835287751665837 0.0004138063814779 0.0 0.0 0.0 0.0 34 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1027477 THBS2 CD36 THBS2-CD36 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0056789469137132 0.9197297916541942 0.8587566561291643 0.9429656149619918 0.0039472834455595 0.0011409783203169 0.0 9.742790335151988e-05 0.0744458672796063 0.0 2566 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1027638 VEGFC FLT1 VEGFC-FLT1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.005676346829204 0.8963332422588541 0.4630488285702799 0.7204611100467462 0.0026007495851186 0.0043013567716651 0.0 0.0005112474437627 0.0405475580889812 0.0 326 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1027648 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0056762259191627 0.2490567623945399 0.7480927101953669 0.2461374514707439 0.011649387573427 0.006260692484444 0.0 0.0 0.0 0.0 84 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1027754 CD34 SELP CD34-SELP Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0056744621923966 0.7871981482311898 0.4623922682986163 0.2461374514707439 0.0038506427265089 0.0096770075292062 0.0 0.0 0.0 0.0 122 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1027961 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0056710184582326 0.7482742921073442 0.7461459456652184 1.0 0.005733874009046 0.0010390313650636 0.0 0.0003533568904593 0.0518173141970097 0.0 1132 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1028073 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0056689241634127 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0141923232885854 0.0007400708115376 0.0 0.0003086419753086 0.0711277440604914 0.0 81 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1028141 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.005667857215635 0.7840818683779507 0.6571792026963191 0.6198216015396206 0.0032417203409647 0.0032020139126304 0.0 0.0 0.0 0.0 32 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1028189 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0056669371283586 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0025256125075084 0.0047273851759697 0.0 0.0 0.0 0.0 422 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1028222 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.005666372499377 0.8840293712888387 0.7461459456652184 0.7827641335561659 0.0061698665784747 0.0010390313650636 0.0 0.000190114068441 0.0278788971820413 0.0 526 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1028303 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0056647836456438 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0020491452254277 0.0056518532344078 0.0 2.599292992306093e-05 0.0215374892949689 0.0 6412 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1028425 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0056630903508269 0.6301823358791634 0.8514619504364779 0.6198216015396206 0.0172764782878141 0.0005740632036187 0.0 0.0 0.0 0.0 18 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1028511 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0056614540803746 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0113788029360913 0.0007400708115376 0.0 0.0 0.0 0.0 209 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1028512 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.005661433183857 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0799339500711946 0.0001189339410417 0.0 0.0 0.0 0.0 4880 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1028566 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0056607002457517 0.6589792304505506 0.7346293219749174 0.6198216015396206 0.0033973231723341 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1028577 THBS2 CD36 THBS2-CD36 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0056603858723342 0.8858959974474152 0.6176321640000088 0.6198216015396206 0.0030563796158022 0.0031731220372828 0.0 0.0 0.0 0.0 129 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1028637 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0056597317110353 0.4593282471594782 0.6614977577544194 0.2461374514707439 0.0181222899145132 0.0024251058581756 0.0 0.0 0.0 0.0 147 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1028708 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0056584510397786 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0071496754272206 0.0016667952436519 0.0 0.0001100919401959 0.0136831522863434 0.0 4232 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1028725 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0056581921584544 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.000716220684292 0.0118035014556376 0.0 0.0 0.0 0.0 69 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1028802 C3 LRP1 C3-LRP1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0056567963947822 0.9487258305485792 0.8755243548400705 0.8567148457705164 0.0110943464444434 0.0004150165744076 0.0 0.0003030303030303 0.0873423428332258 0.0 165 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1028933 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0056542817524 0.2490567623945399 0.6571792026963191 0.2461374514707439 0.011649387573427 0.0069630688870869 0.0 0.0 0.0 0.0 147 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1029079 MMP2 PECAM1 MMP2-PECAM1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0056517705054055 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0024819960935566 0.0041555861088636 0.0 0.001 0.1899984109697348 0.0 50 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1029090 CD34 SELP CD34-SELP T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0056515116546634 0.633566764858408 0.7760344326192508 0.9318789094584046 0.015517736049123 0.0004582650848664 0.0 9.98003992015968e-05 0.0742574185480679 0.0 5010 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1029092 COL4A1 CD93 COL4A1-CD93 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0056514440468144 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0016831757123532 0.0042738820064046 0.0 0.0001475796930342 0.0106661193231835 0.0 968 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1029093 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0056514400238414 0.4629984640915818 0.2550748532138862 0.2461374514707439 0.3309594876493178 0.0003386430177035 0.0 0.0013888888888888 0.1979604079184164 0.0 230 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1029275 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0056484193633567 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.002196330917593 0.0042655619249233 0.0 0.0 0.0 0.0 1490 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1029304 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0056478955376094 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0016417770622885 0.0064230792457803 0.0 0.0 0.0 0.0 10 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1029357 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0056471159535435 0.6213271600240247 0.8617632615906476 0.6198216015396206 0.0093830613230477 0.0010414441948928 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1029409 VWF LRP1 VWF-LRP1 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0056462550248148 0.7848266128497919 0.9078204025796472 0.7827641335561659 0.0004024409845247 0.0144359394371152 0.0 0.0002223320158102 0.0196396536565333 0.0 460 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1029441 VWF LRP1 VWF-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0056457490533726 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0036144684673052 0.0028784826949613 0.0 0.0 0.0 0.0 97 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1029471 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells -> Basal-like Structured DCIS Cells 0.0056451184009792 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0034559943126159 0.0030676679668133 0.0 1.7817982456140353e-05 0.0116129117456489 0.0 30400 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1029495 CD34 SELP CD34-SELP Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0056447971494284 0.7168245244832976 0.8347297932672282 0.7204611100467462 0.0082993421103349 0.0009042150166242 0.0 0.0 0.0 0.0 38 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1029543 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0056439451462977 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0151307911035231 0.0007261054236978 0.0 0.0 0.0 0.0 422 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1029576 CD48 CD2 CD48-CD2 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0056431901709504 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0467114894617178 0.0003671083100858 0.0 0.0 0.0 0.0 8 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1029577 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.005643174840473 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0078992851324392 0.0022515473538965 0.0 0.0 0.0 0.0 79 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1029663 VWF SELP VWF-SELP B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0056416087706847 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.00023686843287 0.04130664769978 0.0 5.703205201323144e-05 0.0193575047276715 0.0 797 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1029851 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0056387975665325 0.6659645551150886 0.7464347811605867 0.6198216015396206 0.0081474500750471 0.0012805120781881 0.0 0.0 0.0 0.0 143 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1029873 VWF LRP1 VWF-LRP1 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0056384692938212 0.9011206516381156 0.6207977546603366 0.6198216015396206 0.0008850282134344 0.0104714078116759 0.0 0.0002542200528777 0.0213433107457147 0.0 3576 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1030050 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.005635915789074 0.7766289238087107 0.8347945881127203 0.8567148457705164 0.0047694898966413 0.0012097093680331 0.0 0.0 0.0 0.0 137 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1030108 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0056350266555931 0.7487535481622718 0.7757991160529997 0.7827641335561659 0.0015847932820241 0.0044430418127202 0.0 0.0098814229249011 0.3693785953291997 0.0 23 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1030274 VWF ITGA9 VWF-ITGA9 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0056323565294724 0.9011206516381156 0.2531744428854943 0.2461374514707439 0.0008850282134344 0.0642389143033604 0.0 0.0010369858278603 0.0485349369527355 0.0 263 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1030290 VWF SELP VWF-SELP Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0056320837056141 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0025256125075084 0.0036702914086929 0.0 1.322314049586777e-05 0.0055153701292009 0.0 6875 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1030383 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Plasma Cells CAFs, DCIS Associated -> Plasma Cells 0.0056303310584486 0.7205550478301406 0.4630027772793905 0.8767341187813953 0.0117842887908422 0.0009242223287825 0.0 0.000203832042397 0.0202474127020354 0.0 2453 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1030490 THBS2 CD36 THBS2-CD36 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0056285903557233 0.8858959974474152 0.6176321640000088 0.6198216015396206 0.0030563796158022 0.0030676679668133 0.0 0.0 0.0 0.0 594 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1030577 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0056271241830239 0.8771078809726828 0.7470475610360806 0.7827641335561659 0.0080232294691882 0.0007714919761827 0.0 0.0 0.0 0.0 179 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1030674 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0056254609455519 0.6303682835571691 0.4614667734221426 0.2461374514707439 0.0002750231449378 0.1609352200462838 0.0 0.0007242440702516 0.0152149047181282 0.0 263 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1030773 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0056236800950141 0.8640667164982425 0.7167436199046466 0.7204611100467462 0.002676946692949 0.0026482500471321 0.0 0.0 0.0 0.0 1884 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1030979 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.005620290463031 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.000895875398841 0.0090444648829713 0.0 0.0 0.0 0.0 193 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1031311 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0056147412151243 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0015847932820241 0.0064230792457803 0.0 0.0 0.0 0.0 30 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1031316 VWF SELP VWF-SELP Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0056146762092492 0.6332974881236617 0.7760344326192508 1.0 0.0019871862905238 0.0032078747392388 0.0 2.266494413091272e-05 0.0037609610531691 0.0 4011 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1031406 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0056131022222306 0.250044481781731 0.4630027772793905 0.2461374514707439 0.0070431301838115 0.0155837683010033 0.0 0.0002049600327936 0.0278739072454827 0.0 4879 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1031456 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0056124316416295 0.9197297916541942 0.2562573700401372 0.2461374514707439 0.0055862851962672 0.0096442330625583 0.0 0.0 0.0 0.0 1491 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1031590 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0056101124535783 0.6303682835571691 0.4614667734221426 0.2461374514707439 0.0002705513462707 0.1609352200462838 0.0 0.0060622034791776 0.1273546475645169 0.0 271 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1031619 VWF SELP VWF-SELP Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0056096702446306 0.6332974881236617 0.7760344326192508 0.8693461273411047 0.0019871862905238 0.0036702914086929 0.0 0.0 0.0 0.0 1245 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1031622 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0056096281483222 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0052560850129547 0.0019304335593669 0.0 0.0 0.0 0.0 38 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1031630 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0056095327591948 0.7451589345683471 0.7841656220878274 1.0 0.0040724665904272 0.001309307002134 0.0 0.0004416961130742 0.054553538036889 0.0 1132 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1031647 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0056091777282451 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0020251995753771 0.0053724660607752 0.0 0.0 0.0 0.0 79 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1031928 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Basal-like Structured DCIS Cells Dendritic Cells -> Basal-like Structured DCIS Cells 0.0056041151742451 0.6301823358791634 0.6347970925105053 0.8693461273411047 0.0015409900107563 0.0057802287131517 0.0 0.0004016064257028 0.0690921713644985 0.0 1245 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1031981 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0056033868694483 0.6582846571368821 0.4630027772793905 0.2461374514707439 0.0084325366891025 0.0048929293424311 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1032097 A2M LRP1 A2M-LRP1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0056014071435038 0.7741139100414175 0.7769451595923457 0.6198216015396206 0.0149044683666724 0.0005558995075445 0.0 0.0003462603878116 0.0654865053234576 0.0 361 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1032174 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0056000004872859 0.2451358214448441 0.7426180951053148 0.2461374514707439 0.1327555461750915 0.0005184623914895 0.0 0.0031179138321995 0.3667687240507506 0.0 84 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1032235 VEGFC FLT1 VEGFC-FLT1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0055992105081133 0.7745997874735252 0.7472387841445823 0.6198216015396206 0.0012459853895406 0.0068935067166085 0.0 0.0 0.0 0.0 137 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1032396 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0055964240963564 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0101610580570933 0.0008609682710384 0.0 0.0001618425147836 0.0485542890207275 0.0 11475 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1032499 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0055948657173726 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.00146889578236 0.0053794918117879 0.0 0.0 0.0 0.0 2152 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1032608 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0055931187844409 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0104129581710415 0.0076066460958003 0.0 0.0003420752565564 0.1443694880713457 0.0 877 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1032702 VWF ITGA9 VWF-ITGA9 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0055914914726482 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0019871862905238 0.0053724660607752 0.0 0.0 0.0 0.0 239 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1032727 A2M LRP1 A2M-LRP1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0055911831398407 0.7460047258226694 0.6207977546603366 0.6198216015396206 0.0010163752993685 0.0104714078116759 0.0 0.0003221649484536 0.0442199645749238 0.0 388 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1032850 VWF SELP VWF-SELP Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0055890217969191 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0020251995753771 0.0045674276780054 0.0 3.5511363636363635e-05 0.0059768477346586 0.0 1280 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1032939 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0055875579011003 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0001971810371238 0.0521257226458961 0.0 0.0 0.0 0.0 119 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1032978 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0055870049362136 0.8840293712888387 0.4630027772793905 0.2461374514707439 0.0061698665784747 0.0048929293424311 0.0 0.0 0.0 0.0 1491 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1033076 HSPG2 LRP1 HSPG2-LRP1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0055852277416548 0.8818165186409654 0.2550748532138862 0.2461374514707439 0.1619074107723045 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1033114 VWF LRP1 VWF-LRP1 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0055845664825139 0.7158082793127664 0.2550748532138862 0.2461374514707439 0.0025256125075084 0.0267255153180908 0.0 0.0003705148205928 0.0202619917702136 0.0 12820 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1033224 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0055825882798993 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0028649117803088 0.0032020139126304 0.0 0.0 0.0 0.0 209 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1033258 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0055821052092009 0.7160288858520609 0.8818120773736414 0.7204611100467462 0.0012306151710811 0.0054043611446182 0.0 0.0 0.0 0.0 337 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1033324 CD48 CD2 CD48-CD2 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0055809457382092 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0467114894617178 0.0002517784065132 0.0 0.0 0.0 0.0 306 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1033390 VWF SELP VWF-SELP Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0055799571463423 0.8525936146535493 0.6572093097629401 0.6198216015396206 0.0002103933337194 0.04130664769978 0.0 0.0 0.0 0.0 78 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1033529 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0055777419749351 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0048525806497539 0.0018097844702233 0.0 0.0 0.0 0.0 409 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1033716 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0055746314539942 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0020251995753771 0.0047273851759697 0.0 0.0003126709919487 0.0146615211500767 0.0 1163 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1033725 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0055745538566119 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0051428381563772 0.0032187363284526 0.0 0.000438596491228 0.0863947785329839 0.0 285 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1033741 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.005574147732443 0.2490567623945399 0.4638256179742202 0.3990376746076917 0.000126812416921 0.5131068416842878 0.0 0.0 0.0 0.0 89 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1033896 VWF SELP VWF-SELP Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0055713990948359 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0019871862905238 0.0045674276780054 0.0 0.0 0.0 0.0 246 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1033902 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0055712459563649 0.7205550478301406 0.8514619504364779 0.7204611100467462 0.0117842887908422 0.0005740632036187 0.0 0.0003080714725816 0.0532517910352384 0.0 1082 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1033916 C3 LRP1 C3-LRP1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0055710010795839 0.2485046029682279 0.8604147465201248 0.2461374514707439 0.0013028322726017 0.0436001007095475 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1033929 CD34 SELP CD34-SELP Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0055707167642652 0.633566764858408 0.4623922682986163 0.2461374514707439 0.0042829523358709 0.0096770075292062 0.0 0.0006648936170212 0.6032239777897295 0.0 752 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1034035 CD34 SELP CD34-SELP Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0055691595790414 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0042829523358709 0.002113171886167 0.0 0.0004239084357778 0.122781130828917 0.0 2359 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1034250 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0055659704681752 0.7160288858520609 0.7480927101953669 0.7204611100467462 0.0012306151710811 0.006260692484444 0.0 0.0 0.0 0.0 43 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1034263 VWF ITGA9 VWF-ITGA9 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0055657474437561 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0003457348439318 0.0309945332907452 0.0 0.000241458408789 0.0150619053439314 0.0 753 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1034306 CD34 SELP CD34-SELP Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0055649200884191 0.8963354148873306 0.6572093097629401 0.6198216015396206 0.0038492365148421 0.002113171886167 0.0 0.0 0.0 0.0 1354 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1034397 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0055634382559437 0.2485046029682279 0.9078204025796472 0.2461374514707439 0.0036991419150414 0.0144359394371152 0.0 0.0002076411960132 0.0354598619819917 0.0 1806 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1034410 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0055632723414226 0.6659645551150886 0.4603649459881741 0.2461374514707439 0.0037243679732516 0.0105486447632276 0.0 0.0 0.0 0.0 19 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1034424 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0055629827830778 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0037243679732516 0.0024832440877005 0.0 0.0 0.0 0.0 345 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1034483 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.005561910786255 0.6332974881236617 0.6572093097629401 1.0 0.0015572459193676 0.0045674276780054 0.0 0.0001757263355201 0.0295761537385169 0.0 1552 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1034565 VWF LRP1 VWF-LRP1 B Cells Pericytes B Cells -> Pericytes 0.0055604077157474 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.00023686843287 0.0350138403862125 0.0 0.0002345919975977 0.0095828016501926 0.0 1211 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1034590 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0055599689615202 0.6342079770588467 0.4641352222874551 0.2461374514707439 0.000895875398841 0.0455121851821151 0.0 0.0 0.0 0.0 19 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1034746 VWF ITGA9 VWF-ITGA9 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0055570541259917 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0019871862905238 0.0047273851759697 0.0 0.0 0.0 0.0 209 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1034779 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0055565421857464 0.6626993710110988 0.6207977546603366 1.0 0.0039530346951707 0.0018097844702233 0.0 0.0006094257854821 0.0672336992081387 0.0 1846 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1034841 C1QB LRP1 C1QB-LRP1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0055555104841899 0.4601010570874773 0.7346293219749174 1.0 0.0026949121497638 0.0032275631628407 0.0 0.0004416961130742 0.0176022410784579 0.0 283 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1034937 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0055538170233858 0.9067635403815892 0.8537710813834968 0.8567148457705164 0.0106922602624424 0.0004138063814779 0.0 0.0007299270072992 0.1062603706034772 0.0 137 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1034944 MMRN2 CD93 MMRN2-CD93 B Cells 11q13 Invasive Tumor Cells B Cells -> 11q13 Invasive Tumor Cells 0.0055535643496382 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0003083910058032 0.0289462771086338 0.0 0.0 0.0 0.0 797 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1034982 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0055529808356627 0.4648000335061383 0.2550748532138862 0.2461374514707439 0.2966815529783992 0.0003386430177035 0.0 0.0009057971014492 0.1493818308237186 0.0 230 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1035002 C1QB LRP1 C1QB-LRP1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0055526312063899 0.7753420160918723 0.7769451595923457 0.7827641335561659 0.0111808254589153 0.0005558995075445 0.0 0.0001977848101265 0.0249527172429533 0.0 316 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1035025 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0055521471445978 0.7835752212271604 0.7470475610360806 1.0 0.0064863313435223 0.0007714919761827 0.0 0.0005153121319199 0.0791260978162924 0.0 1132 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1035039 VEGFC FLT1 VEGFC-FLT1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0055518883158844 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.0023125636768155 0.0066828239855783 0.0 0.0 0.0 0.0 285 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1035060 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0055514731461026 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0008320501336843 0.0125623889131764 0.0 0.0003246753246753 0.1045870163108433 0.0 77 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1035099 DLL4 NOTCH3 DLL4-NOTCH3 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0055507768951874 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0002327631000826 0.0689186266365139 0.0 0.0 0.0 0.0 4087 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1035152 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0055497929584669 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.002676946692949 0.0032187363284526 0.0 0.0 0.0 0.0 1422 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1035194 CCN1 CAV1 CCN1-CAV1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0055490904914617 0.6213271600240247 0.943345641464811 0.6198216015396206 0.0023088899408624 0.0034806998160403 0.0 0.000125 0.0462759623430678 0.0 800 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1035227 CD34 SELP CD34-SELP CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0055486851391512 0.9303167350027568 0.6572093097629401 0.6198216015396206 0.0016860250240652 0.0045674276780054 0.0 0.0 0.0 0.0 390 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1035335 C1QB LRP1 C1QB-LRP1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0055470831717375 0.8703788833238396 0.6207977546603366 0.7917001487310438 0.0037630364713574 0.0018097844702233 0.0 0.0 0.0 0.0 42 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1035413 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0055455505860151 0.9468422434493456 0.2491545808994955 0.2461374514707439 0.1120119983652299 0.0004471667362236 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1035443 C3 LRP1 C3-LRP1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0055452581020662 0.7796725988275006 0.9078204025796472 0.7827641335561659 0.000819605673545 0.0064028969591119 0.0 0.0001423149905123 0.0269621487342312 0.0 527 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1035446 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0055451782877713 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0126216524880575 0.0009242223287825 0.0 0.0001001803245842 0.0193246619935379 0.0 713 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1035495 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0055444483276782 0.6160088550075702 0.6632137581773894 0.9161861017439124 0.0009692519480124 0.0080072638027924 0.0 0.000198491464867 0.0479457832510706 0.0 458 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1035497 C3 LRP1 C3-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0055444200809692 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0013028322726017 0.0587195251380622 0.0 0.0002717391304347 0.0655822264332937 0.0 184 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1035535 VWF SELP VWF-SELP T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0055435641381429 0.6332974881236617 0.7478729882108823 0.6198216015396206 0.0036144684673052 0.0027351735586246 0.0 0.0 0.0 0.0 361 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1035536 THBS2 CD36 THBS2-CD36 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0055435563325246 0.8858959974474152 0.7763054211764489 0.7827641335561659 0.0030563796158022 0.0017638974017382 0.0 0.0002327746741154 0.0334283618082887 0.0 179 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1035598 VWF SELP VWF-SELP Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0055424565361324 0.8525936146535493 0.7760344326192508 0.6198216015396206 0.0002103933337194 0.0335947364052305 0.0 0.0005300821627352 0.0283568033904934 0.0 343 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1035810 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0055389255760297 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0172764782878141 0.0009242223287825 0.0 0.0 0.0 0.0 79 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1035833 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0055385980326023 0.6213271600240247 0.8617632615906476 0.6198216015396206 0.0083518627398662 0.0010414441948928 0.0 0.0008830022075055 0.1115913353620066 0.0 151 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1035981 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0055360531604995 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0151307911035231 0.000671064546954 0.0 0.0 0.0 0.0 394 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1036065 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0055344558605572 0.8718210606749883 0.6593689120110077 0.6198216015396206 0.0017670878089588 0.0045642085393754 0.0 0.0004074979625101 0.0467039276051957 0.0 409 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1036079 CCN1 CAV1 CCN1-CAV1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0055341766503304 0.6213271600240247 0.252518874138558 0.2461374514707439 0.0023088899408624 0.0322196586137726 0.0 0.0007898894154818 0.1382276058161237 0.0 211 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1036088 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0055340147687575 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0097699360831605 0.0076066460958003 0.0 0.0 0.0 0.0 184 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1036092 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0055339228704669 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0001971810371238 0.0491709261488903 0.0 0.0 0.0 0.0 119 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1036159 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0055328701818096 0.743507317541692 0.6593689120110077 0.6198216015396206 0.0020684923107111 0.0045642085393754 0.0 0.0 0.0 0.0 32 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1036228 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.005531805720312 0.7205550478301406 0.7154802332407408 0.8767341187813953 0.0002165306714062 0.0292771742399634 0.0 0.0002721088435374 0.0311725702645095 0.0 2450 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1036252 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Macrophages Macrophages -> Macrophages 0.0055313300445103 0.8949858186325867 0.8923034233058523 1.0 0.001895566065636 0.00189193058407 0.0 0.0001356116083536 0.0599941221405601 0.0 2458 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1036253 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.005531322564956 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0101610580570933 0.0008542071298387 0.0 0.0002587991718426 0.0477987733717379 0.0 4232 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1036258 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0055312252524312 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0036991419150414 0.0203874717835032 0.0 0.0004157427937915 0.0531782569413244 0.0 902 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1036336 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0055299499555371 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0009153913192522 0.0104714078116759 0.0 6.645401382243488e-05 0.0066464503913914 0.0 1881 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1036377 VWF SELP VWF-SELP T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0055292612007235 0.6332974881236617 0.941479368642921 0.6198216015396206 0.0036144684673052 0.0021392900294222 0.0 3.96290718871364e-05 0.007098305508597 0.0 3441 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1036485 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0055272013188558 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0024319941937022 0.0041555861088636 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1036497 CD48 CD2 CD48-CD2 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0055269258023678 0.7719609236370527 0.7763428264267787 0.8875000050982297 0.0212837736082081 0.0002517784065132 0.0 0.0 0.0 0.0 1462 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1036651 VWF LRP1 VWF-LRP1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0055243675176968 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.00023686843287 0.0416128058995347 0.0 0.0002061950146627 0.0085493445392113 0.0 496 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1036663 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0055241257191639 0.7487535481622718 0.7447682696221608 1.0 0.0015847932820241 0.0032154705418133 0.0 0.0010038548024413 0.0852114021997672 0.0 1132 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1036704 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0055235386735625 0.8840293712888387 0.7779918296243433 0.6198216015396206 0.0061698665784747 0.001079730675535 0.0 0.0 0.0 0.0 791 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1037147 VWF SELP VWF-SELP CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0055159369039073 0.6332974881236617 0.6572093097629401 0.9161861017439124 0.0016171311116606 0.0045674276780054 0.0 0.0 0.0 0.0 526 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1037159 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0055157521071971 0.9067635403815892 0.6331674633943454 0.6198216015396206 0.0106922602624424 0.0007400708115376 0.0 0.0 0.0 0.0 409 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1037192 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0055151612098326 0.6160088550075702 0.8628183098412396 0.7917001487310438 0.0001971810371238 0.0339152418223636 0.0 0.0001148809067932 0.0087771664258106 0.0 1187 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1037297 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0055134652613121 0.9275752708651288 0.9078204025796472 0.9429656149619918 0.000245041593909 0.0144359394371152 0.0 6.289835625628984e-05 0.005556113580569 0.0 2710 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1037326 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0055131042298465 0.7451589345683471 0.6331674633943454 0.6198216015396206 0.0040724665904272 0.0023576674662702 0.0 0.0015432098765432 0.4790654941593389 0.0 162 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1037414 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0055117737827987 0.9303167350027568 0.941479368642921 0.8875000050982297 0.0016860250240652 0.0021392900294222 0.0 0.0 0.0 0.0 1424 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1037447 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0055112241423371 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0021291294377375 0.0044430418127202 0.0 0.0 0.0 0.0 18 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1037562 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0055092857401602 0.6332974881236617 0.6252253442669611 0.9592803095773328 0.0015572459193676 0.0047273851759697 0.0 0.0001216175129218 0.0057027923403141 0.0 1495 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1037655 THBS2 CD36 THBS2-CD36 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0055077307987447 0.2510234128936706 0.8587566561291643 0.2461374514707439 5.260070730345377e-05 1.0 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1037691 VWF SELP VWF-SELP Myoepithelial Cells Dendritic Cells Myoepithelial Cells -> Dendritic Cells 0.0055070870109158 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0025256125075084 0.0032078747392388 0.0 3.3373381391002534e-05 0.0055378908899637 0.0 1362 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1037721 DLL4 NOTCH3 DLL4-NOTCH3 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0055065836587413 0.6342079770588467 0.6580560501976399 0.7917001487310438 0.0002327631000826 0.0362497659817488 0.0 0.0 0.0 0.0 42 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1037819 VWF SELP VWF-SELP CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0055049423354419 0.7158082793127664 0.8347297932672282 0.7204611100467462 0.0071496754272206 0.0009042150166242 0.0 8.401949252226517e-05 0.0068788701287663 0.0 1082 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1037857 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0055041550653954 0.9303167350027568 0.4623922682986163 0.7204611100467462 0.0016860250240652 0.0053213839468185 0.0 0.0 0.0 0.0 1884 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1037919 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0055031491914432 0.6160088550075702 0.6631822525600675 0.8824495942126559 0.0001971810371238 0.0390724515618796 0.0 5.639521768554026e-05 0.0318643771233602 0.0 12090 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1037938 MMP2 PECAM1 MMP2-PECAM1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0055026909449243 0.9330801352629944 0.930308383061206 0.8875000050982297 0.0088108219576754 0.0004089864655001 0.0 1.709986320109439e-05 0.031060561841787 0.0 1462 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1037946 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Dendritic Cells Basal-like Structured DCIS Cells -> Dendritic Cells 0.00550252094414 0.6332974881236617 0.7760344326192508 0.8693461273411047 0.0020251995753771 0.0032078747392388 0.0 0.0 0.0 0.0 1044 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1037990 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.005501752129522 0.8911088195487638 0.6207977546603366 0.6198216015396206 0.0048525806497539 0.0016667952436519 0.0 0.0004108723135271 0.0754650266267501 0.0 791 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1037992 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.005501734736429 0.6332974881236617 0.6252253442669611 0.9161861017439124 0.0016171311116606 0.0047273851759697 0.0 0.0 0.0 0.0 460 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1038030 C3 LRP1 C3-LRP1 B Cells B Cells B Cells -> B Cells 0.0055010215587475 0.6319926036888139 0.6207977546603366 1.0 0.0042375227960614 0.0016667952436519 0.0 0.0004231311706629 0.0777166141630804 0.0 1418 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1038078 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0055003603831286 0.9303167350027568 0.7760344326192508 0.6198216015396206 0.0016860250240652 0.0036702914086929 0.0 0.0 0.0 0.0 1332 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1038087 C3 LRP1 C3-LRP1 Pericytes Myeloid Cells Pericytes -> Myeloid Cells 0.0055001842176788 0.8911088195487638 0.7769451595923457 0.7827641335561659 0.0091898156146168 0.0005558995075445 0.0 0.0003164556962025 0.0709443781574881 0.0 316 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1038120 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0054995037443379 0.6160088550075702 0.4596166826058663 0.2461374514707439 0.0052742025956585 0.0075270071967493 0.0 0.0008616975441619 0.3803827536941467 0.0 211 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1038252 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0054973450831826 0.2491408586098361 0.7167436199046466 0.2461374514707439 0.0049987108499989 0.0125623889131764 0.0 0.0002766960442713 0.0891315461816943 0.0 4879 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1038258 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.005497211770619 0.6332974881236617 0.7831795333113832 0.6198216015396206 0.0016171311116606 0.0055509879377996 0.0 0.0 0.0 0.0 143 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1038399 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0054947579552856 0.718867305289982 0.7167436199046466 0.8293805866303694 0.0024319941937022 0.0026482500471321 0.0 0.0 0.0 0.0 324 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1038429 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0054943114390561 0.7741139100414175 0.2550748532138862 0.2461374514707439 0.1671376945154473 0.0003386430177035 0.0 0.0006003842459173 0.0990138936295541 0.0 694 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1038465 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0054938107516732 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0083898580598364 0.0008609682710384 0.0 0.0002396931927133 0.0719102305772906 0.0 1490 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1038502 MMRN2 CD93 MMRN2-CD93 T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes -> 11q13 Invasive Tumor Cells (Mitotic) 0.0054930425173298 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0031934983073077 0.0026174949623928 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1038703 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Pericytes Luminal-like Amorphous DCIS Cells -> Pericytes 0.0054894199385396 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0061207051981986 0.0091569531245039 0.0 5.236698785085882e-05 0.0137068571335056 0.0 1736 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1038813 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0054873905702274 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.000245041593909 0.0309945332907452 0.0 0.0 0.0 0.0 1881 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1038907 COL4A1 CD93 COL4A1-CD93 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0054860919532449 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.0002970267018348 0.0289462771086338 0.0 0.0018315018315018 0.2706847741161128 0.0 78 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1038909 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0054860759587553 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0003788349535045 0.0218093597373452 0.0 0.0026610644257703 0.1442172758377271 0.0 170 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1039129 VWF ITGA9 VWF-ITGA9 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0054819455283852 0.9011206516381156 0.7831795333113832 0.7827641335561659 0.0008850282134344 0.0055509879377996 0.0 0.0 0.0 0.0 179 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1039151 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0054816742042722 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0078992851324392 0.0010419094417808 0.0 0.0 0.0 0.0 1163 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1039216 VWF ITGA9 VWF-ITGA9 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0054802760350192 0.6332974881236617 0.6252253442669611 0.9318789094584046 0.00023686843287 0.0309945332907452 0.0 9.118263882556762e-05 0.0056878709749149 0.0 4985 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1039442 C1QB LRP1 C1QB-LRP1 Pericytes Mast Cells Pericytes -> Mast Cells 0.0054767721099903 0.7753420160918723 0.8755243548400705 0.8567148457705164 0.0111808254589153 0.0004150165744076 0.0 0.0 0.0 0.0 225 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1039534 COL4A1 CD93 COL4A1-CD93 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0054751434886426 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0168149984327668 0.0003375370073613 0.0 7.747133560582584e-05 0.0675033164606233 0.0 922 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1039606 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Endothelial Cells Luminal-like Amorphous DCIS Cells -> Endothelial Cells 0.0054738601734583 0.2486570577556728 0.9078204025796472 0.2461374514707439 0.0033537993821664 0.0144359394371152 0.0 0.0003334843451122 0.0294582721881556 0.0 1806 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1039629 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0054735228551222 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.00146889578236 0.0057802287131517 0.0 7.744733581164808e-05 0.0133240014480794 0.0 2152 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1039650 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0054732410191448 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0161757332769496 0.0009249287638231 0.0 0.0003486750348675 0.2007383942937146 0.0 239 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1039685 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0054725595250843 0.2490567623945399 0.8818326005152037 0.2461374514707439 0.011649387573427 0.0042655619249233 0.0 0.0002408477842003 0.0523136561823051 0.0 1384 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1039703 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0054723087447687 0.6342079770588467 0.6571792026963191 0.9161861017439124 0.002196330917593 0.0032020139126304 0.0 0.0 0.0 0.0 460 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1039853 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0054693538309235 0.6301823358791634 0.6587114738285964 1.0 0.0024635726452692 0.0026174949623928 0.0 0.0004832474226804 0.1605046406100158 0.0 1552 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1039867 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0054691370234981 0.6160088550075702 0.6632137581773894 0.7917001487310438 0.0021291294377375 0.0038860320327025 0.0 0.0003908387399359 0.2210893263360166 0.0 1163 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1039942 C3 LRP1 C3-LRP1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0054676734734059 0.8509500867818902 0.9078204025796472 0.8567148457705164 0.0006305085967044 0.0064028969591119 0.0 0.0001689189189189 0.0320023702318465 0.0 148 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1040027 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0054661637696882 0.6582846571368821 0.7461459456652184 0.6198216015396206 0.0084325366891025 0.0010390313650636 0.0 0.0 0.0 0.0 21 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1040029 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0054661581096803 0.940547666092272 0.6347970925105053 0.6198216015396206 0.0001298888146421 0.0554888093272979 0.0 2.9327233268813417e-05 0.0047996132731534 0.0 5683 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1040043 VWF ITGA9 VWF-ITGA9 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0054659707505904 0.6332974881236617 0.950463483645931 0.6198216015396206 0.0036144684673052 0.0019776346124415 0.0 0.0 0.0 0.0 1880 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1040085 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0054651894725771 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0055862851962672 0.0009761781830445 0.0 0.0 0.0 0.0 285 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1040094 VWF SELP VWF-SELP Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.005465102860343 0.7158082793127664 0.7478729882108823 0.7204611100467462 0.0025256125075084 0.0027351735586246 0.0 0.0 0.0 0.0 51 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1040110 CD34 SELP CD34-SELP Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0054647745546443 0.7168245244832976 0.4623922682986163 0.8293805866303694 0.0018206581062216 0.0053213839468185 0.0 0.0 0.0 0.0 324 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1040189 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0054634720642162 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0021291294377375 0.0038621268649178 0.0 7.102272727272727e-05 0.0439004522469909 0.0 1280 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1040202 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.005463348592147 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0002750231449378 0.0373075519081129 0.0 0.0005537098560354 0.0104478896044968 0.0 129 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1040226 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0054627477453041 0.6332974881236617 0.7831795333113832 0.6198216015396206 0.0015572459193676 0.0055509879377996 0.0 0.0 0.0 0.0 23 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1040275 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0054619229059016 0.6582846571368821 0.6587114738285964 1.0 0.0084325366891025 0.0007261054236978 0.0 0.0 0.0 0.0 1846 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1040400 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0054593707640964 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0014378253178126 0.0071918009517169 0.0 0.0002653927813163 0.0648653796855648 0.0 1884 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1040579 THBS2 CD36 THBS2-CD36 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0054565918111461 0.6242573126045354 0.7763054211764489 0.6198216015396206 0.004981832968137 0.0017638974017382 0.0 0.0 0.0 0.0 161 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1040615 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0054560049060488 0.6303682835571691 0.4614667734221426 0.7204611100467462 9.902323108165852e-05 0.12709315903692 0.0 0.0016467682173734 0.0775775101131217 0.0 1041 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1040684 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0054547241431146 0.6160088550075702 0.4600037439857229 0.2461374514707439 0.0021291294377375 0.017738069381683 0.0 0.0001036591686534 0.0258432776523984 0.0 877 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1040685 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.005454701996762 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0018436902762588 0.0036702914086929 0.0 0.0 0.0 0.0 1187 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1040728 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0054539799259465 0.6249837837987587 0.8341464445360613 0.6198216015396206 0.0435116250366991 0.0001871866311057 0.0 0.0002502502502502 0.0317698050695532 0.0 333 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1040798 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Pericytes 11q13 Invasive Tumor Cells (Mitotic) -> Pericytes 0.0054529635990786 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0009692519480124 0.0091569531245039 0.0 0.0001199328376109 0.0313919577622241 0.0 379 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1040801 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0054529481239163 0.7797135509308979 0.62431395375366 0.6198216015396206 0.0009209869688402 0.009460730808256 0.0 0.0001960784313725 0.0243443199337646 0.0 170 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1040864 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.005451797130464 0.9470274865242416 0.7470475610360806 0.7827641335561659 0.0061455194924501 0.0007714919761827 0.0 0.0 0.0 0.0 526 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1040908 VWF SELP VWF-SELP Myoepithelial Cells Macrophages Myoepithelial Cells -> Macrophages 0.0054510023606908 0.7158082793127664 0.941479368642921 0.7204611100467462 0.0025256125075084 0.0021392900294222 0.0 0.0 0.0 0.0 591 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1041051 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0054484424070668 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0002705513462707 0.0373075519081129 0.0 0.0158730158730158 0.2995061686622418 0.0 3 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1041171 CD34 SELP CD34-SELP Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0054461252084302 0.7871981482311898 0.6572093097629401 0.6198216015396206 0.0038506427265089 0.002113171886167 0.0 0.003125 0.9051271488294228 0.0 160 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1041221 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0054452265130993 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0003788349535045 0.0265498740402422 0.0 0.0022321428571428 0.0567075659237686 0.0 32 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1041235 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.005444982555669 0.6301823358791634 0.6587114738285964 1.0 0.00146889578236 0.0042738820064046 0.0 0.0002831791580139 0.0361487956804526 0.0 5297 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1041276 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0054441365198122 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0024635726452692 0.0058437228618857 0.0 0.0 0.0 0.0 714 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1041338 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0054430369748275 0.6342079770588467 0.836885603004631 0.6198216015396206 0.0028649117803088 0.0027591088867233 0.0 0.0 0.0 0.0 151 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1041374 A2M LRP1 A2M-LRP1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0054423786282134 0.7741139100414175 0.8755243548400705 0.6198216015396206 0.0149044683666724 0.0004150165744076 0.0 0.0003753753753753 0.0546000546000546 0.0 333 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1041397 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0054421658382501 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0033537993821664 0.0203874717835032 0.0 0.0001511791977423 0.0070786284764598 0.0 902 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1041475 THBS2 CD36 THBS2-CD36 Pericytes Mast Cells Pericytes -> Mast Cells 0.0054409786890633 0.9197297916541942 0.8765901449012573 0.8567148457705164 0.0087456089304998 0.0004295051170816 0.0 0.0003703703703703 0.0448567850033046 0.0 225 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1041505 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.005440494619675 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0004094805141934 0.0203874717835032 0.0 0.0001895534962089 0.0242460595253957 0.0 1187 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1041619 CD34 SELP CD34-SELP Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0054386578394537 0.8963354148873306 0.4623922682986163 0.7204611100467462 0.0038492365148421 0.0022515473538965 0.0 0.0 0.0 0.0 326 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1041741 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0054365874338631 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.0026436039558049 0.0028784826949613 0.0 7.122507122507122e-05 0.0052664261708514 0.0 390 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1041799 VWF ITGA9 VWF-ITGA9 Macrophages B Cells Macrophages -> B Cells 0.0054354985699696 0.9011206516381156 0.6252253442669611 0.6198216015396206 0.0008850282134344 0.0083442542366581 0.0 0.0001692906720839 0.0093190963434885 0.0 1074 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1041828 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0054350037418695 0.4593282471594782 0.7763428264267787 0.2461374514707439 0.0181222899145132 0.0016204239758814 0.0 0.0 0.0 0.0 222 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1041830 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0054349736634537 0.4629984640915818 0.6207977546603366 0.2461374514707439 0.0201301851612071 0.0018097844702233 0.0 0.0 0.0 0.0 26 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1041922 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0054337136839083 0.6589792304505506 0.2550748532138862 0.2461374514707439 0.1836996873148393 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1042187 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0054286346439252 0.2490567623945399 0.7746834992804791 0.2461374514707439 0.011649387573427 0.0046263543438723 0.0 0.0 0.0 0.0 316 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1042232 CD34 SELP CD34-SELP B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.005427812713626 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0006336851232098 0.0222228052993653 0.0 0.0 0.0 0.0 4087 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1042272 COL4A2 CD93 COL4A2-CD93 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0054270988238357 0.9188764516910942 0.4630027772793905 0.7204611100467462 0.0090193130488293 0.0009242223287825 0.0 0.0003067484662576 0.0584971743145845 0.0 326 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1042396 C3 LRP1 C3-LRP1 Pericytes Mast Cells Pericytes -> Mast Cells 0.005425041643055 0.8911088195487638 0.8755243548400705 0.8567148457705164 0.0091898156146168 0.0004150165744076 0.0 0.0005555555555555 0.1601276285275807 0.0 225 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1042440 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0054241110393214 0.6303642896310324 0.6331674633943454 0.8824495942126559 0.0097699360831605 0.0007400708115376 0.0 2.911813643926789e-05 0.0067103878339931 0.0 12020 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1042445 DLL4 NOTCH4 DLL4-NOTCH4 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0054240526073939 0.6342079770588467 0.7754072541855492 0.9318789094584046 0.0002327631000826 0.0238720285974944 0.0 0.0 0.0 0.0 4985 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1042447 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0054240295993404 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0024635726452692 0.003263637675389 0.0 0.0 0.0 0.0 209 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1042479 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0054233660161492 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0001959417442809 0.0455125113141721 0.0 0.0 0.0 0.0 77 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1042504 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0054229750116148 0.6160088550075702 0.6632137581773894 1.0 0.0009692519480124 0.0064230792457803 0.0 0.0001171508903467 0.0157567598510398 0.0 1552 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1042509 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0054229277441203 0.6301823358791634 0.7830372268649692 0.6198216015396206 0.0031934983073077 0.0026038611777234 0.0 0.0 0.0 0.0 361 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1042574 VEGFC FLT1 VEGFC-FLT1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0054218162168522 0.8963332422588541 0.8331580262014722 0.8567148457705164 0.0026007495851186 0.001526625481682 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1042628 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.005420923831387 0.7797135509308979 0.8818704453527788 0.7827641335561659 0.0009209869688402 0.0051192928876727 0.0 0.0 0.0 0.0 162 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1042719 C3 LRP1 C3-LRP1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0054192681170217 0.2485046029682279 0.9078204025796472 0.2461374514707439 0.0013028322726017 0.0350138403862125 0.0 0.0027777777777777 0.2440181151928807 0.0 9 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1042754 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0054185537531672 0.6303682835571691 0.4614667734221426 0.2461374514707439 0.000219642761279 0.1609352200462838 0.0 0.0003672830634601 0.007715875137488 0.0 1491 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1042871 CD34 SELP CD34-SELP Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0054163942744033 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.0082993421103349 0.0010419094417808 0.0 0.0 0.0 0.0 422 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1042888 MMP2 PECAM1 MMP2-PECAM1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.005416184151096 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0024819960935566 0.0032187363284526 0.0 0.0005423553719008 0.1577910412540957 0.0 968 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1042906 MMRN2 CLEC14A MMRN2-CLEC14A B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0054157999529487 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0003083910058032 0.0292771742399634 0.0 0.0 0.0 0.0 4087 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1042948 VWF SELP VWF-SELP T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0054149843444625 0.6332974881236617 0.4623922682986163 0.2461374514707439 0.0036144684673052 0.0096770075292062 0.0 0.0 0.0 0.0 383 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1043017 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0054138428806245 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0015409900107563 0.0058465532256424 0.0 0.0002360717658168 0.0496853778818243 0.0 1412 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1043026 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.005413644765658 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0117842887908422 0.0007261054236978 0.0 0.0 0.0 0.0 135 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1043036 VWF SELP VWF-SELP T Lymphocytes CAFs, Invasive Associated T Lymphocytes -> CAFs, Invasive Associated 0.0054134706911994 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0036144684673052 0.002113171886167 0.0 3.787878787878788e-05 0.0075831811380561 0.0 2400 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1043065 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0054129192268224 0.6589792304505506 0.6207977546603366 1.0 0.0033973231723341 0.0018097844702233 0.0 0.0002783796797881 0.0247664117748892 0.0 1846 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1043081 THBS2 CD36 THBS2-CD36 Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0054125048962434 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0027791828709671 0.0032616151102094 0.0 0.0002134016218523 0.0675837950515586 0.0 1562 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1043096 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0054122634308569 0.6626993710110988 0.6207977546603366 0.9592803095773328 0.0035190936623492 0.0018097844702233 0.0 0.0001672240802675 0.0184486672223298 0.0 1495 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1043139 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0054115762323316 0.9303167350027568 0.7478729882108823 0.7827641335561659 0.0016860250240652 0.0027351735586246 0.0 0.0 0.0 0.0 526 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1043159 C3 LRP1 C3-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0054112723612681 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.005043231651446 0.0018097844702233 0.0 5.924170616113744e-05 0.0209200246475926 0.0 422 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1043223 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0054101446318353 0.6561647292424944 0.7769451595923457 0.6198216015396206 0.0142750905665976 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1043228 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Macrophages Mast Cells -> Macrophages 0.0054100709676649 0.8624864526942296 0.8923034233058523 0.8567148457705164 0.0020100505037262 0.00189193058407 0.0 0.0 0.0 0.0 165 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1043249 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0054097816140826 0.6593525851613742 0.878254460598671 0.6198216015396206 0.0120646829101097 0.0005788283879716 0.0 0.0 0.0 0.0 380 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1043375 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0054071451977273 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0012306151710811 0.0069630688870869 0.0 0.0 0.0 0.0 285 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1043506 VWF LRP1 VWF-LRP1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0054045857187342 0.9275752708651288 0.2550748532138862 0.2461374514707439 0.1263644540569636 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1043579 MMP2 PECAM1 MMP2-PECAM1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0054032311636502 0.9330801352629944 0.8537710813834968 0.8567148457705164 0.0088108219576754 0.0004138063814779 0.0 0.0001515151515151 0.0220570769282975 0.0 165 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1043598 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0054028652705073 0.6249837837987587 0.8341464445360613 0.6198216015396206 0.0411214967239829 0.0001871866311057 0.0 0.0012820512820512 0.1627591552024803 0.0 130 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1043601 THBS2 CD36 THBS2-CD36 Mast Cells 11q13 Invasive Tumor Cells Mast Cells -> 11q13 Invasive Tumor Cells 0.0054027481400955 0.8581959463413404 0.6176321640000088 0.6198216015396206 0.0002636300075004 0.02871400543887 0.0 0.0 0.0 0.0 78 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1043602 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0054027166594205 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0016171311116606 0.0053724660607752 0.0 0.0 0.0 0.0 253 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1043606 CCN1 CAV1 CCN1-CAV1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0054026740844523 0.7324582304061453 0.62431395375366 0.6198216015396206 0.0025580826958339 0.0034299077593249 0.0 0.0 0.0 0.0 8 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1043639 CXCL12 ITGA4 CXCL12-ITGA4 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0054020436936803 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0052742025956585 0.0015914585039484 0.0 5.681818181818182e-05 0.0275846650897132 0.0 800 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1043653 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0054018614991076 0.4629984640915818 0.9078204025796472 0.7204611100467462 0.0012814156885439 0.0064028969591119 0.0 0.0010893246187363 0.1289016121346057 0.0 306 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1043712 C3 LRP1 C3-LRP1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.005400924633581 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0013028322726017 0.0501711964086628 0.0 0.007421875 0.2135500638324299 0.0 64 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1043780 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.005399897036364 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0003788349535045 0.0312252462757311 0.0 0.0016806722689075 0.0915360233847756 0.0 85 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1043785 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053997858784392 0.4604235282221027 0.6587114738285964 0.2461374514707439 0.0126864732057784 0.0026174949623928 0.0 0.0007659900421294 0.0746653008010749 0.0 373 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1043788 MMRN2 CD93 MMRN2-CD93 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0053996813343694 0.7856500335676843 0.7779918296243433 0.6198216015396206 0.0005542667491398 0.0118035014556376 0.0 0.0 0.0 0.0 388 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1043805 VWF LRP1 VWF-LRP1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0053993878845212 0.7848266128497919 0.6207977546603366 0.6198216015396206 0.0004024409845247 0.0203874717835032 0.0 0.0007014590347923 0.032844253527607 0.0 162 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1043817 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0053990598787149 0.633566764858408 0.8347297932672282 0.6198216015396206 0.0083565457974945 0.0009042150166242 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1043895 CD48 CD2 CD48-CD2 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0053976851727931 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0212837736082081 0.0003671083100858 0.0 0.0 0.0 0.0 129 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1043949 CCN1 CAV1 CCN1-CAV1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0053968669543942 0.8749036366850302 0.7283139964676212 0.7204611100467462 0.0004337320404416 0.0124087765732037 0.0 0.0 0.0 0.0 50 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1043973 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0053961444798473 0.7487535481622718 0.4600037439857229 0.2461374514707439 0.0016417770622885 0.017738069381683 0.0 0.0 0.0 0.0 41 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1044018 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.005395330565327 0.4636527906642655 0.878254460598671 0.7204611100467462 0.014525360548861 0.0005788283879716 0.0 0.0 0.0 0.0 1538 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1044152 THBS2 CD36 THBS2-CD36 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.005393074627148 0.8581959463413404 0.6176321640000088 0.6198216015396206 0.0002636300075004 0.0284069116891947 0.0 0.0 0.0 0.0 162 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1044221 COL4A2 CD93 COL4A2-CD93 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0053917917945889 0.9188764516910942 0.6587114738285964 0.6198216015396206 0.0090193130488293 0.0007261054236978 0.0 0.0007751937984496 0.1190510873149993 0.0 129 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1044340 COL4A1 CD93 COL4A1-CD93 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0053897624715526 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0016831757123532 0.0058437228618857 0.0 0.0 0.0 0.0 496 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1044408 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0053886076969988 0.7158082793127664 0.950463483645931 0.7204611100467462 0.0025256125075084 0.0019776346124415 0.0 0.0 0.0 0.0 1538 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1044440 THBS2 CD36 THBS2-CD36 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053877485565708 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0027791828709671 0.0031731220372828 0.0 0.0001896813353566 0.0850322436761926 0.0 659 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1044604 THBS2 CD36 THBS2-CD36 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.005384991588709 0.724503440376099 0.7373999388878224 0.8293805866303694 0.0009736808737186 0.0056518532344078 0.0 0.0002572016460905 0.2131147860483652 0.0 324 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1044641 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0053843023615984 0.4601010570874773 0.7769451595923457 0.7204611100467462 0.0170183763647696 0.0005558995075445 0.0 0.0 0.0 0.0 51 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1044653 C3 LRP1 C3-LRP1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0053841427258254 0.2485046029682279 0.7346293219749174 0.2461374514707439 0.0013028322726017 0.0416128058995347 0.0 0.0011739594450373 0.1096485587018189 0.0 937 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1044663 COL4A2 CD93 COL4A2-CD93 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0053840099911843 0.8355319038299565 0.7779918296243433 0.6198216015396206 0.001123788079051 0.0053794918117879 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1044674 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0053837816404133 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0104129581710415 0.0007400708115376 0.0 0.0001074806534823 0.0247693347760095 0.0 1163 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1044731 CCN1 CAV1 CCN1-CAV1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0053826419394043 0.6213271600240247 0.62431395375366 0.7917001487310438 0.0023088899408624 0.0034299077593249 0.0 0.0047619047619047 0.4926108374384236 0.0 42 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1044784 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0053819868707715 0.6342079770588467 0.7746834992804791 0.9318789094584046 0.0073929685753755 0.00071798405859 0.0 6.65335994677312e-05 0.0351579334060505 0.0 5010 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1044811 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.005381344879005 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0208904415011529 0.0003375370073613 0.0 0.0 0.0 0.0 4880 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1044819 CD34 SELP CD34-SELP Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.005381224581458 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.0018206581062216 0.0045674276780054 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1044830 CD48 CD2 CD48-CD2 CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0053810610744936 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0351142257737683 0.0003671083100858 0.0 0.0 0.0 0.0 135 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1044852 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0053806207390188 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0101610580570933 0.0006800116997025 0.0 0.0005941378399788 0.0510486663952968 0.0 1082 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1044865 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages B Cells Macrophages -> B Cells 0.0053804562980062 0.8771078809726828 0.7746834992804791 0.6198216015396206 0.0080232294691882 0.00071798405859 0.0 0.0 0.0 0.0 1074 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1044919 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells Basal-like Structured DCIS Cells -> Basal-like Structured DCIS Cells 0.0053795551522349 0.6242573126045354 0.6176321640000088 1.0 0.0020491452254277 0.0030676679668133 0.0 1.0642283067701947e-05 0.0069361328838241 0.0 19576 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1044977 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0053782871144278 0.9303167350027568 0.7760344326192508 0.6198216015396206 0.0016860250240652 0.0032078747392388 0.0 0.0 0.0 0.0 887 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1045050 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.005376957429642 0.4630253981438691 0.6587114738285964 0.2461374514707439 0.0443339118517084 0.0007261054236978 0.0 0.0 0.0 0.0 26 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1045098 A2M LRP1 A2M-LRP1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.005376015683753 0.4648000335061383 0.7346293219749174 1.0 0.0021905373114471 0.0032275631628407 0.0 0.0010306242638398 0.0608646019569894 0.0 283 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1045249 THBS2 CD36 THBS2-CD36 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0053733881635722 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0063387366560491 0.0096442330625583 0.0 0.0 0.0 0.0 383 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1045264 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0053731860256594 0.7463064942968751 0.7779918296243433 0.6198216015396206 0.0012430446376512 0.0053794918117879 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1045302 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0053725088648481 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.0198024073017111 0.0003375370073613 0.0 0.0 0.0 0.0 339 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1045310 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0053723881216802 0.6626993710110988 0.7769451595923457 0.6198216015396206 0.0135527119637784 0.0005558995075445 0.0 0.0 0.0 0.0 143 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1045340 THBS2 CD36 THBS2-CD36 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0053719361961258 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0063387366560491 0.0011409783203169 0.0 4.432624113475177e-05 0.0338702296878492 0.0 1880 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1045408 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0053707820742991 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.00146889578236 0.0058465532256424 0.0 0.0002969121140142 0.0624902793074251 0.0 1684 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1045476 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.005369397236026 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0161193721503025 0.0004089864655001 0.0 0.0001084598698481 0.1970088564541984 0.0 922 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1045512 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0053688450584183 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0015572459193676 0.0053724660607752 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1045537 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053683920369593 0.6303642896310324 0.6331674633943454 1.0 0.0014431743145616 0.0041555861088636 0.0 0.0003543814432989 0.0673319111039653 0.0 1552 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1045564 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0053679296405739 0.7482742921073442 0.4630027772793905 0.2461374514707439 0.005733874009046 0.0048929293424311 0.0 0.0 0.0 0.0 122 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1045602 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0053672178377605 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0012814156885439 0.0104714078116759 0.0 0.0010144606758152 0.084795694964244 0.0 753 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1045619 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0053669469631996 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.0085570823799139 0.00071798405859 0.0 0.0 0.0 0.0 42 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1045655 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0053662601058774 0.7160288858520609 0.8818326005152037 0.7204611100467462 0.0012306151710811 0.0042655619249233 0.0 0.0 0.0 0.0 306 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1045659 MMP2 PECAM1 MMP2-PECAM1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0053661983373028 0.9330801352629944 0.6331674633943454 0.6198216015396206 0.0088108219576754 0.0007400708115376 0.0 0.0 0.0 0.0 129 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1045671 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053659525091233 0.6301823358791634 0.6347970925105053 0.9161861017439124 0.00146889578236 0.0044340558155446 0.0 0.0 0.0 0.0 526 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1045749 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0053644679884763 0.7487535481622718 0.4600037439857229 0.2461374514707439 0.0015847932820241 0.017738069381683 0.0 0.0003725782414307 0.0928875184473501 0.0 122 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1045766 C3 LRP1 C3-LRP1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0053640670940569 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0042375227960614 0.0018097844702233 0.0 0.0 0.0 0.0 42 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1045768 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0053640419689077 0.6342079770588467 0.6571792026963191 0.9161861017439124 0.000895875398841 0.0069630688870869 0.0 0.0 0.0 0.0 408 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1045898 EFNB2 PECAM1 EFNB2-PECAM1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053618060519018 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0014623066995027 0.0041555861088636 0.0 0.0 0.0 0.0 50 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1045905 VEGFC FLT1 VEGFC-FLT1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0053616357516731 0.8317042416754105 0.777821334064334 0.6198216015396206 0.0005440770361181 0.0108892901157311 0.0 0.0010288065843621 0.1276637543885441 0.0 162 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1045941 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0053609288599533 0.4629984640915818 0.6207977546603366 0.2461374514707439 0.0201301851612071 0.0016667952436519 0.0 0.0006313131313131 0.0798705598144703 0.0 176 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1046050 COL4A1 CD93 COL4A1-CD93 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0053585752626088 0.9102252263107924 0.7461459456652184 0.7827641335561659 0.0042860632265532 0.0010390313650636 0.0 0.0 0.0 0.0 179 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1046109 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Basal-like Structured DCIS Cells Myoepithelial Cells -> Basal-like Structured DCIS Cells 0.0053574844981498 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0027791828709671 0.0030676679668133 0.0 2.424242424242424e-05 0.0158000567079263 0.0 6875 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1046156 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0053566326872551 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0007263013575398 0.0104714078116759 0.0 0.0 0.0 0.0 83 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1046216 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0053556728715295 0.2491408586098361 0.2491073778594529 1.0 0.0049987108499989 0.0076066460958003 0.0 7.548874120911033e-05 0.0318592786663929 0.0 77495 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1046339 THBS2 CD36 THBS2-CD36 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.005353673210083 0.8858959974474152 0.8587566561291643 0.8875000050982297 0.0030563796158022 0.0011409783203169 0.0 5.699954400364797e-05 0.0435540573277405 0.0 1462 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1046528 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0053503943571411 0.4593282471594782 0.7763428264267787 0.2461374514707439 0.0181222899145132 0.0014748371602574 0.0 0.0 0.0 0.0 34 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1046590 CD48 CD2 CD48-CD2 Endothelial Cells CXCL14+ Fibroblasts Endothelial Cells -> CXCL14+ Fibroblasts 0.0053493598339019 0.7719609236370527 0.7763428264267787 0.9429656149619918 0.0164675938709007 0.0002517784065132 0.0 0.0 0.0 0.0 2566 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1046614 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0053486598692156 0.633566764858408 0.8347297932672282 0.6198216015396206 0.0078992851324392 0.0009042150166242 0.0 0.0 0.0 0.0 18 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1046615 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0053486197233307 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0131302879503246 0.0004582650848664 0.0 0.0 0.0 0.0 570 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1046642 THBS2 CD36 THBS2-CD36 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0053481205355797 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0087456089304998 0.0007598956708367 0.0 0.0006631299734748 0.3119151590767314 0.0 377 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1046682 VWF SELP VWF-SELP Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0053475044328386 0.7848266128497919 0.4623922682986163 0.7204611100467462 0.0004024409845247 0.0222228052993653 0.0 6.982265046781176e-05 0.0115618953748713 0.0 1302 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1046698 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0053472928669019 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0151307911035231 0.0003375370073613 0.0 0.0001625487646293 0.1205557683390795 0.0 1538 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1046701 COL4A2 CD93 COL4A2-CD93 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053472312616053 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.0047240947268779 0.0026174949623928 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1046725 VWF LRP1 VWF-LRP1 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0053468916067204 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0003457348439318 0.0144359394371152 0.0 0.0005936227951153 0.0524375495638783 0.0 536 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1046774 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0053459167886728 0.6249837837987587 0.7746834992804791 0.7917001487310438 0.0084812136822336 0.00071798405859 0.0 0.0 0.0 0.0 38 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1046989 C3 LRP1 C3-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053416398305532 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.0029337538459309 0.0028784826949613 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1047032 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0053407814430414 0.7719609236370527 0.8581827408615759 0.6198216015396206 0.0014378253178126 0.003930762149527 0.0 0.0 0.0 0.0 1332 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1047037 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0053406902742887 0.8949858186325867 0.4641352222874551 0.7204611100467462 0.001895566065636 0.0040904475843412 0.0 0.0 0.0 0.0 326 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1047062 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0053403297568456 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.0037268694422441 0.0018097844702233 0.0 0.000203748981255 0.0274921544583254 0.0 409 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1047206 C3 LRP1 C3-LRP1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0053375504587367 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.005043231651446 0.0016667952436519 0.0 0.0003807106598984 0.069925227717797 0.0 394 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1047270 VWF SELP VWF-SELP CAFs, Invasive Associated Basal-like Structured DCIS Cells CAFs, Invasive Associated -> Basal-like Structured DCIS Cells 0.0053364182198519 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0016171311116606 0.0036702914086929 0.0 4.224400135180805e-05 0.0176199673040224 0.0 2152 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1047381 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0053344823780678 0.7487535481622718 0.7447682696221608 0.7827641335561659 0.0016417770622885 0.0032154705418133 0.0 0.0 0.0 0.0 23 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1047388 CD34 SELP CD34-SELP Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0053343582773733 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.0018206581062216 0.0036702914086929 0.0 0.0 0.0 0.0 126 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1047432 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0053336420559305 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0018436902762588 0.0032078747392388 0.0 0.0 0.0 0.0 193 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1047444 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0053334713167531 0.7719609236370527 0.4603649459881741 0.7204611100467462 0.0014378253178126 0.0062523288579129 0.0 0.0017543859649122 0.0207355612250254 0.0 285 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1047489 VEGFC FLT1 VEGFC-FLT1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0053326315173033 0.7745997874735252 0.6593689120110077 0.7917001487310438 0.0012459853895406 0.0045642085393754 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1047820 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0053268061106172 0.8913986641324685 0.2491073778594529 0.2461374514707439 0.0054950348959687 0.0076066460958003 0.0 0.0007129277566539 0.2970111467025129 0.0 263 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1047951 CCN1 CAV1 CCN1-CAV1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053246325461287 0.7797135509308979 0.62431395375366 0.6198216015396206 0.0009209869688402 0.0082011408892332 0.0 0.0055555555555555 0.9317269296131764 0.0 30 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1048068 CD34 SELP CD34-SELP Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0053225582917382 0.7871981482311898 0.4623922682986163 0.7204611100467462 0.0038506427265089 0.0022515473538965 0.0 0.0 0.0 0.0 37 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1048086 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0053223316739113 0.7468485855611411 0.9078204025796472 0.7827641335561659 0.0006689050756654 0.0064028969591119 0.0 0.0003953194180898 0.0467788108553004 0.0 527 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1048112 CD48 CD2 CD48-CD2 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0053217079277838 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0351142257737683 0.0002517784065132 0.0 0.0 0.0 0.0 11475 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1048117 HSPG2 LRP1 HSPG2-LRP1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0053216210282363 0.9253089325030373 0.6207977546603366 0.6198216015396206 0.0022161183602947 0.0028784826949613 0.0 0.0 0.0 0.0 129 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1048298 MMRN2 CD93 MMRN2-CD93 Myeloid Cells CAFs, DCIS Associated Myeloid Cells -> CAFs, DCIS Associated 0.0053186790728728 0.7856500335676843 0.4630027772793905 0.7204611100467462 0.0005542667491398 0.0155837683010033 0.0 0.0001920122887864 0.0261130555780933 0.0 1302 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1048479 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0053150543482926 0.4601010570874773 0.6207977546603366 0.2461374514707439 0.0177188549930425 0.0018097844702233 0.0 0.0 0.0 0.0 26 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1048491 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Endothelial Cells Dendritic Cells -> Endothelial Cells 0.0053148969729804 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0016575843792215 0.0032875740549697 0.0 0.0001540357362908 0.0248544338099836 0.0 2164 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1048564 VWF ITGA9 VWF-ITGA9 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0053137490984627 0.9011206516381156 0.7292496872084557 0.7204611100467462 0.0008850282134344 0.0053724660607752 0.0 0.0 0.0 0.0 326 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1048652 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0053124598411861 0.7766289238087107 0.7461459456652184 0.7827641335561659 0.0047694898966413 0.0010390313650636 0.0 0.0001357957631721 0.0129205650576662 0.0 526 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1048716 VEGFC FLT1 VEGFC-FLT1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0053114364979747 0.8317042416754105 0.8998347793593909 0.8567148457705164 0.0005440770361181 0.0064362797035136 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1048762 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0053106312012192 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0014431743145616 0.0049190726392343 0.0 0.0 0.0 0.0 42 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1048771 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0053104671488653 0.9184503888425788 0.4641352222874551 0.2461374514707439 0.0004696576149175 0.0455121851821151 0.0 0.0 0.0 0.0 1491 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1048789 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.005310155297027 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0117842887908422 0.000671064546954 0.0 3.9382482671707626e-05 0.0130617930753554 0.0 4232 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1048947 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.005307331076884 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0003521782369754 0.0203874717835032 0.0 0.0003542161292793 0.0165853795825169 0.0 1187 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1048975 COL4A2 CD93 COL4A2-CD93 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0053069519904106 0.7482742921073442 0.7779918296243433 0.6198216015396206 0.005733874009046 0.001079730675535 0.0 0.0 0.0 0.0 144 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1049045 CD34 SELP CD34-SELP Macrophages Mast Cells Macrophages -> Mast Cells 0.005305799530931 0.8963354148873306 0.8347297932672282 0.8567148457705164 0.0038492365148421 0.0009042150166242 0.0 0.0 0.0 0.0 165 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1049075 VWF SELP VWF-SELP Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0053052395633132 0.7158082793127664 0.4623922682986163 0.8767341187813953 0.0003457348439318 0.0222228052993653 0.0 1.855287569573284e-05 0.0030721607710372 0.0 2450 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1049163 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0053038421476086 0.6332974881236617 0.7769451595923457 0.6198216015396206 0.0131302879503246 0.0005558995075445 0.0 0.0002104377104377 0.0263645880841006 0.0 756 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1049184 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0053034601097402 0.6303642896310324 0.8537710813834968 0.6198216015396206 0.0161193721503025 0.0004138063814779 0.0 0.0013245033112582 0.1928168314261771 0.0 151 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1049208 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.005302962267945 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0015572459193676 0.0036702914086929 0.0 0.0 0.0 0.0 1305 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1049423 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0052985301888747 0.8949858186325867 0.6571792026963191 0.6198216015396206 0.001895566065636 0.0032020139126304 0.0 0.0 0.0 0.0 129 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1049473 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0052977154631132 0.8718210606749883 0.4630488285702799 0.7204611100467462 0.0017670878089588 0.0043013567716651 0.0 0.0 0.0 0.0 285 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1049512 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0052970198994759 0.2534163760166434 0.7746834992804791 0.2461374514707439 0.0050543892975134 0.0090444648829713 0.0 0.0 0.0 0.0 64 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1049525 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0052968074613914 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0024319941937022 0.0032187363284526 0.0 0.0007894736842105 0.2296868089232551 0.0 285 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1049526 THBS2 CD36 THBS2-CD36 Endothelial Cells Luminal-like Amorphous DCIS Cells Endothelial Cells -> Luminal-like Amorphous DCIS Cells 0.0052968009540784 0.9197297916541942 0.2562573700401372 0.2461374514707439 0.0039472834455595 0.0096442330625583 0.0 4.0160642570281125e-05 0.0408851607963283 0.0 2075 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1049557 VWF LRP1 VWF-LRP1 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0052963252889437 0.6332974881236617 0.6207977546603366 0.9318789094584046 0.0036144684673052 0.0016667952436519 0.0 9.526401741970602e-05 0.0118402133293599 0.0 5010 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1049561 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0052961976129338 0.743507317541692 0.4630488285702799 0.7204611100467462 0.0020684923107111 0.0043013567716651 0.0 0.0 0.0 0.0 37 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1049745 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0052926891675948 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0051428381563772 0.0023576674662702 0.0 0.0 0.0 0.0 126 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1049824 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.005291160114362 0.250044481781731 0.6347970925105053 0.2461374514707439 0.0070431301838115 0.0079745943515326 0.0 0.0005274261603375 0.063197747351389 0.0 316 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1049946 COL4A2 CD93 COL4A2-CD93 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0052890450967374 0.9188764516910942 0.8817184225858201 0.8875000050982297 0.0090193130488293 0.0003375370073613 0.0 0.0 0.0 0.0 1462 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1049989 COL4A2 CD93 COL4A2-CD93 B Cells B Cells B Cells -> B Cells 0.0052882328821334 0.7783550150988336 0.7779918296243433 1.0 0.0033449520260795 0.001079730675535 0.0 0.0002115655853314 0.0357789861678148 0.0 1418 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1050094 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0052859769781423 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0003788349535045 0.0222186841038061 0.0 0.0019345238095238 0.0764968843199689 0.0 160 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1050230 COL4A1 CD93 COL4A1-CD93 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0052835189438321 0.9102252263107924 0.4630027772793905 0.2461374514707439 0.0042860632265532 0.0048929293424311 0.0 0.0 0.0 0.0 263 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1050240 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.005283400188391 0.8771078809726828 0.4638256179742202 0.7204611100467462 0.0080232294691882 0.0009249287638231 0.0 0.0 0.0 0.0 326 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1050305 VWF SELP VWF-SELP CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0052821983425263 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0071496754272206 0.0010419094417808 0.0 0.0 0.0 0.0 135 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1050312 THBS2 CD36 THBS2-CD36 Pericytes B Cells Pericytes -> B Cells 0.0052821294595964 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0087456089304998 0.0007053434767499 0.0 0.000156788962057 0.0757535784321033 0.0 1063 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1050323 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0052819642610613 0.7941469661104034 0.773263018678637 0.6198216015396206 0.0083898580598364 0.0006800116997025 0.0 0.0051282051282051 0.4406183467555309 0.0 130 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1050482 MMRN2 CD93 MMRN2-CD93 Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.0052790778217989 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0015409900107563 0.0042738820064046 0.0 0.0006358626536668 0.0811700596521227 0.0 2359 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1050492 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0052789122902072 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0015409900107563 0.0044340558155446 0.0 0.0006775067750677 0.0883505771796206 0.0 246 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1050531 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0052781359896124 0.4630253981438691 0.4630027772793905 0.2461374514707439 0.0443339118517084 0.0009242223287825 0.0 0.0 0.0 0.0 272 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1050539 C3 LRP1 C3-LRP1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0052780162541672 0.8509500867818902 0.6207977546603366 0.6198216015396206 0.0006305085967044 0.0104714078116759 0.0 0.0018221574344023 0.1793080959016448 0.0 343 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1050607 A2M LRP1 A2M-LRP1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0052766735768603 0.8392912392980421 0.9078204025796472 0.8567148457705164 0.0005164482812395 0.0064028969591119 0.0 0.0 0.0 0.0 148 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1050637 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0052762096329253 0.6213271600240247 0.7832252605020791 0.6198216015396206 0.0052560850129547 0.00136079311934 0.0 0.0 0.0 0.0 21 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1050675 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0052755579717366 0.893316592628645 0.6347970925105053 0.6198216015396206 0.0007691101630988 0.0079745943515326 0.0 4.660700969425801e-05 0.0055845884124829 0.0 3576 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1050699 VWF ITGA9 VWF-ITGA9 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0052750980834336 0.8525936146535493 0.6252253442669611 0.6198216015396206 0.0002103933337194 0.0309945332907452 0.0 0.0005300821627352 0.0330659321398845 0.0 343 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1050757 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0052740174503078 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0020251995753771 0.0267255153180908 0.0 0.000323934902042 0.0177147200448284 0.0 877 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1050894 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0052715784106874 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0039530346951707 0.0016667952436519 0.0 0.0 0.0 0.0 38 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1051010 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0052691802481794 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.002676946692949 0.0023576674662702 0.0 0.0002815315315315 0.0873970833939334 0.0 1332 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1051051 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0052683093725993 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0028649117803088 0.0040904475843412 0.0 0.0 0.0 0.0 239 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1051095 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0052675743596792 0.8937519114898692 0.6207977546603366 0.6198216015396206 0.0037268694422441 0.0016667952436519 0.0 0.0 0.0 0.0 791 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1051114 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0052672866961528 0.4636527906642655 0.4630488285702799 1.0 0.0023125636768155 0.0043013567716651 0.0 0.0005889281507656 0.0467084944770596 0.0 283 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1051199 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0052654825474064 0.6659645551150886 0.6614977577544194 0.9592803095773328 0.0137371823984124 0.0003671083100858 0.0 0.0 0.0 0.0 1495 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1051216 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0052652155375809 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0048313935743179 0.001079730675535 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1051387 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0052624039710464 0.6303682835571691 0.663300745568453 0.6198216015396206 0.000219642761279 0.0373075519081129 0.0 0.0008547008547008 0.0161272552356591 0.0 390 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1051453 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0052613907529859 0.7475533330314548 0.885766439573873 0.7827641335561659 0.0029751676683741 0.0013756087909864 0.0 0.0003162555344718 0.1191622142580124 0.0 527 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1051652 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0052574351525637 0.8349903778527206 0.7346293219749174 0.7204611100467462 0.0014804857410621 0.0032275631628407 0.0 0.0002777777777777 0.0152735077008487 0.0 50 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1051656 VWF LRP1 VWF-LRP1 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0052573879860321 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0019871862905238 0.0267255153180908 0.0 0.0002417794970986 0.0132219655143102 0.0 752 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1051695 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0052566585727489 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0141923232885854 0.0004089864655001 0.0 3.9893617021276594e-05 0.0724636299138713 0.0 1880 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1051702 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0052565462151758 0.6561647292424944 0.8755243548400705 0.6198216015396206 0.0142750905665976 0.0004150165744076 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1051709 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0052563921540214 0.2486570577556728 0.4623922682986163 0.2461374514707439 0.0033537993821664 0.0222228052993653 0.0 4.658182563491028e-05 0.007713459611643 0.0 4879 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1051775 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.005255323960101 0.6160088550075702 0.8622452992050237 0.7917001487310438 0.0001971810371238 0.0254056950469408 0.0 0.0002680554491843 0.0421197026468024 0.0 1187 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1051869 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.005253450484051 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0004094805141934 0.0144359394371152 0.0 9.541984732824427e-05 0.0162952953535565 0.0 262 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1051965 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0052516157430002 0.250044481781731 0.6347970925105053 0.2461374514707439 0.0070431301838115 0.0076236123034427 0.0 0.0 0.0 0.0 147 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1052028 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0052504790600999 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0131302879503246 0.0040430820937484 0.0 0.0 0.0 0.0 179 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1052067 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0052497317423823 0.7800321422220979 0.930308383061206 0.6198216015396206 0.0113788029360913 0.0004089864655001 0.0 6.778741865509762e-05 0.0871277745450594 0.0 922 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1052095 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0052491017746369 0.8516956437178343 0.4641352222874551 0.2461374514707439 0.000472352586488 0.0455121851821151 0.0 0.0 0.0 0.0 41 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1052155 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.0052479288930888 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0006856224272495 0.0073658308476012 0.0 0.0001660646821937 0.0302361446567124 0.0 3441 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1052180 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0052472336756011 0.6303682835571691 0.8891607331132086 0.6198216015396206 9.902323108165852e-05 0.0606680526002441 0.0 0.0 0.0 0.0 30 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1052304 C1QB LRP1 C1QB-LRP1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0052443924370528 0.4601010570874773 0.2550748532138862 0.2461374514707439 0.0026949121497638 0.0267255153180908 0.0 0.0004612546125461 0.0286943320694175 0.0 271 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1052404 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0052426432973504 0.4601010570874773 0.6207977546603366 0.2461374514707439 0.0177188549930425 0.0016667952436519 0.0 0.0 0.0 0.0 176 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1052421 A2M LRP1 A2M-LRP1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.005242340649477 0.4648000335061383 0.2550748532138862 0.2461374514707439 0.2100317344087863 0.0003386430177035 0.0 0.0013107721639656 0.2161693223931409 0.0 1049 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1052450 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0052417549190828 0.8349903778527206 0.2550748532138862 0.2461374514707439 0.0014804857410621 0.0267255153180908 0.0 0.0020325203252032 0.1214987198105351 0.0 41 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1052536 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0052402427765209 0.893316592628645 0.7154802332407408 0.7204611100467462 0.0007691101630988 0.0058465532256424 0.0 0.0 0.0 0.0 715 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1052609 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0052388374548925 0.9184503888425788 0.7754072541855492 0.6198216015396206 0.0004696576149175 0.009971631136135 0.0 0.0 0.0 0.0 887 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1052655 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0052380494504035 0.7766289238087107 0.4630027772793905 0.2461374514707439 0.0047694898966413 0.0048929293424311 0.0 4.790648653827728e-05 0.0128913031492728 0.0 1491 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1052747 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.005236130205601 0.893316592628645 0.6347970925105053 0.6198216015396206 0.0007691101630988 0.0076236123034427 0.0 0.0 0.0 0.0 1354 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1052752 COL4A1 CD93 COL4A1-CD93 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0052360418323563 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.0017253404164066 0.0053794918117879 0.0 0.0 0.0 0.0 126 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1052809 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0052348918809993 0.6342079770588467 0.7754072541855492 0.9318789094584046 0.0073929685753755 0.0006074333625108 0.0 0.0 0.0 0.0 5010 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1052909 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0052327393646937 0.7160288858520609 0.7470475610360806 0.7204611100467462 0.0069047442087267 0.0007714919761827 0.0 0.0 0.0 0.0 51 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1052978 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0052314376280586 0.4601010570874773 0.8755243548400705 0.7204611100467462 0.0170183763647696 0.0004150165744076 0.0 0.0 0.0 0.0 38 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1053034 MMRN2 CD93 MMRN2-CD93 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0052305154459475 0.8571898293845529 0.7779918296243433 0.6198216015396206 0.0004196880356983 0.0118035014556376 0.0 0.0 0.0 0.0 343 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1053070 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0052298294744242 0.2534163760166434 0.8341464445360613 0.2461374514707439 0.2100740470724093 0.0001871866311057 0.0 0.0 0.0 0.0 34 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1053083 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0052295706227703 0.255669001367946 0.6632137581773894 0.2461374514707439 0.0061207051981986 0.0080072638027924 0.0 0.0 0.0 0.0 147 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1053199 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.0052272972640288 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0020491452254277 0.0032616151102094 0.0 4.463488662738796e-05 0.0141357643104625 0.0 1867 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1053236 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0052264893929841 0.6303682835571691 0.4614667734221426 0.8293805866303694 0.0002705513462707 0.0312252462757311 0.0 0.0013227513227513 0.0720422406269068 0.0 324 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1053274 VWF LRP1 VWF-LRP1 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0052255530121674 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0036144684673052 0.0018097844702233 0.0 0.0 0.0 0.0 81 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1053316 A2M LRP1 A2M-LRP1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0052247667662429 0.7741139100414175 0.2550748532138862 0.2461374514707439 0.0015661096645571 0.0267255153180908 0.0 0.0019747235387045 0.1717760915784253 0.0 211 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1053392 COL4A1 CD93 COL4A1-CD93 Macrophages B Cells Macrophages -> B Cells 0.0052235001672533 0.9102252263107924 0.7779918296243433 0.6198216015396206 0.0042860632265532 0.001079730675535 0.0 0.0 0.0 0.0 1074 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1053412 MMP2 PECAM1 MMP2-PECAM1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0052231403410368 0.6303642896310324 0.6331674633943454 0.8693461273411047 0.0024819960935566 0.0023576674662702 0.0 0.0001388888888888 0.0665976683880111 0.0 360 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1053581 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0052202630288803 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.0085570823799139 0.0006074333625108 0.0 0.0 0.0 0.0 42 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1053582 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0052202171824256 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0008193633790489 0.0069492509109592 0.0 0.0 0.0 0.0 1422 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1053604 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0052198616431246 0.6626993710110988 0.8755243548400705 0.6198216015396206 0.0135527119637784 0.0004150165744076 0.0 0.0 0.0 0.0 130 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1053623 COL4A1 CD93 COL4A1-CD93 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0052195382459582 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0126216524880575 0.0003375370073613 0.0 0.0 0.0 0.0 1880 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1053716 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0052180356209426 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.000716220684292 0.0155837683010033 0.0 0.0 0.0 0.0 77 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1053719 VWF SELP VWF-SELP CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0052179834319696 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0016171311116606 0.0032078747392388 0.0 0.0 0.0 0.0 2339 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1053735 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0052177008205628 0.7719609236370527 0.7763428264267787 0.9429656149619918 0.0014378253178126 0.0024832440877005 0.0 0.0 0.0 0.0 3218 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1053825 VWF LRP1 VWF-LRP1 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0052161016779998 0.8525936146535493 0.9078204025796472 0.8567148457705164 0.0002103933337194 0.0144359394371152 0.0 0.0008234519104084 0.0727394579871603 0.0 276 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1053830 CD34 SELP CD34-SELP Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0052159692072067 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.0018206581062216 0.0032078747392388 0.0 0.0 0.0 0.0 271 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1053856 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0052156004811584 0.7468485855611411 0.6207977546603366 0.6198216015396206 0.0006689050756654 0.0104714078116759 0.0 0.000393757159221 0.032912968200039 0.0 388 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1053867 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Pericytes T Lymphocytes -> Pericytes 0.0052153434888911 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0006856224272495 0.0070956399217802 0.0 0.00028129395218 0.0353033877033988 0.0 3555 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1053879 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0052151847850386 0.6319926036888139 0.7769451595923457 0.6198216015396206 0.011891719340537 0.0005558995075445 0.0 3.306878306878307e-05 0.0074134998339174 0.0 756 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1053882 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Dendritic Cells Dendritic Cells -> Dendritic Cells 0.0052151625236083 0.6301823358791634 0.6347970925105053 1.0 0.0015409900107563 0.003263637675389 0.0 4.155239757333998e-05 0.0041873760187054 0.0 4011 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1053955 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0052136527240899 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0172764782878141 0.0003375370073613 0.0 0.0004508566275924 0.3343819147078526 0.0 1109 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1054003 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0052128147970415 0.9470274865242416 0.7746834992804791 0.6198216015396206 0.0061455194924501 0.00071798405859 0.0 0.0 0.0 0.0 791 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1054027 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0052122924864774 0.6630837220165452 0.8347945881127203 0.6198216015396206 0.0048313935743179 0.0012097093680331 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1054094 VWF LRP1 VWF-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0052110414249771 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0025256125075084 0.0028784826949613 0.0 0.0001379500620775 0.0139817328118327 0.0 659 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1054110 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0052105455228337 0.6301823358791634 0.6347970925105053 0.9161861017439124 0.000716220684292 0.0076236123034427 0.0 0.0 0.0 0.0 408 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1054129 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0052102491568225 0.7487535481622718 0.7462743270426613 1.0 0.0015847932820241 0.0022591041672132 0.0 0.0004818503051718 0.053542518504048 0.0 1132 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1054138 VEGFC FLT1 VEGFC-FLT1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0052100474759635 0.4636527906642655 0.6593689120110077 0.6198216015396206 0.0023125636768155 0.0045642085393754 0.0 0.0 0.0 0.0 8 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1054223 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0052083831352138 0.2491449441646273 0.6572093097629401 0.2461374514707439 0.0108445362943651 0.0045674276780054 0.0 0.0 0.0 0.0 373 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1054246 COL4A1 CD93 COL4A1-CD93 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0052079894253614 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0016831757123532 0.0026174949623928 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1054259 DLL4 NOTCH4 DLL4-NOTCH4 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0052078385362247 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0002327631000826 0.046975263367762 0.0 0.0 0.0 0.0 4087 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1054278 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0052076081781433 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.1932385901170197 0.0002621208738319 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1054309 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0052072182633503 0.6342079770588467 0.836885603004631 0.6198216015396206 0.002196330917593 0.0027591088867233 0.0 0.0 0.0 0.0 130 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1054366 VWF SELP VWF-SELP Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.0052061398489357 0.7158082793127664 0.4623922682986163 0.2461374514707439 0.0025256125075084 0.0096770075292062 0.0 0.0001028222947099 0.029333217856362 0.0 12820 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1054468 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0052041085918466 0.724503440376099 0.7763054211764489 0.7204611100467462 0.0027791828709671 0.0017638974017382 0.0 0.0 0.0 0.0 51 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1054487 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0052037480673038 0.8640667164982425 0.2491073778594529 0.2461374514707439 0.1882781599600688 0.0001990509171164 0.0 0.0 0.0 0.0 15 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1054507 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0052033880484035 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0020491452254277 0.0031731220372828 0.0 0.0001302083333333 0.058371092273553 0.0 1280 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1054642 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0052009467169458 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0002750231449378 0.0218093597373452 0.0 0.000366951759957 0.0198870732599991 0.0 1687 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1054796 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0051978526569385 0.6160088550075702 0.6631822525600675 0.9161861017439124 0.0001971810371238 0.0267210109213584 0.0 0.0004456327985739 0.0468243233659732 0.0 408 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1054968 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0051941431159972 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0016417770622885 0.0038860320327025 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1055013 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.005193382763003 0.6301823358791634 0.7830372268649692 0.6198216015396206 0.0024635726452692 0.0026038611777234 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1055091 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0051921058967378 0.6303642896310324 0.8537710813834968 0.6198216015396206 0.0141923232885854 0.0004138063814779 0.0 0.0011261261261261 0.1639377339265357 0.0 333 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1055101 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0051917709381569 0.4593282471594782 0.7464347811605867 0.2461374514707439 0.0181222899145132 0.0012805120781881 0.0 0.0 0.0 0.0 84 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1055122 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0051913606414568 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0012306151710811 0.0046263543438723 0.0 0.0 0.0 0.0 753 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1055150 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Myoepithelial Cells Basal-like Structured DCIS Cells -> Myoepithelial Cells 0.0051907495373645 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0020251995753771 0.0053213839468185 0.0 2.1266942664322577e-05 0.0097172896385796 0.0 6412 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1055159 C3 LRP1 C3-LRP1 Endothelial Cells Myeloid Cells Endothelial Cells -> Myeloid Cells 0.0051906018491273 0.8911088195487638 0.7769451595923457 0.7827641335561659 0.0064915662046245 0.0005558995075445 0.0 0.0010152284263959 0.2275982080991496 0.0 394 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1055239 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0051887629967699 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0016417770622885 0.0038621268649178 0.0 0.0 0.0 0.0 10 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1055308 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells B Cells Mast Cells -> B Cells 0.0051877479222761 0.8284725546778968 0.6331674633943454 0.6198216015396206 0.0012187708721425 0.0049190726392343 0.0 0.0005580357142857 0.1128402178918499 0.0 112 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1055359 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.005186756468411 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0002705513462707 0.0218093597373452 0.0 0.0014057283429977 0.0761839173195994 0.0 271 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1055368 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0051866563382144 0.6160088550075702 0.7447682696221608 0.6198216015396206 0.0021291294377375 0.0032154705418133 0.0 0.000352360817477 0.0299098627256237 0.0 129 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1055435 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) -> Dendritic Cells 0.0051852699909388 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0015572459193676 0.0032078747392388 0.0 0.0008699434536755 0.1443561223374285 0.0 209 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1055437 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0051852641290455 0.7800321422220979 0.8537710813834968 0.6198216015396206 0.0113788029360913 0.0004138063814779 0.0 0.0012417218543046 0.1084999678518614 0.0 151 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1055485 VWF LRP1 VWF-LRP1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0051842843450993 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0003457348439318 0.0203874717835032 0.0 0.0002705627705627 0.0126684977892198 0.0 126 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1055569 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0051830451324019 0.6342079770588467 0.7470475610360806 0.6198216015396206 0.0085570823799139 0.0007714919761827 0.0 0.0 0.0 0.0 23 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1055684 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0051809501397085 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0037243679732516 0.0016204239758814 0.0 0.0 0.0 0.0 119 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1055747 THBS2 CD36 THBS2-CD36 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0051794882158649 0.6242573126045354 0.6176321640000088 0.9318789094584046 0.0008527942416386 0.0063011237754475 0.0 8.358408559010364e-06 0.0016865982425019 0.0 4985 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1055796 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0051785471900701 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.0047694898966413 0.001079730675535 0.0 9.030160736861116e-05 0.0138996953690629 0.0 791 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1055813 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0051782998012494 0.8516956437178343 0.7754072541855492 0.6198216015396206 0.000472352586488 0.009971631136135 0.0 0.0 0.0 0.0 162 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1055924 CD34 SELP CD34-SELP Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0051762044393459 0.7168245244832976 0.7478729882108823 0.7204611100467462 0.0018206581062216 0.0027351735586246 0.0 0.0 0.0 0.0 43 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1055982 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells CAFs, DCIS Associated Luminal-like Amorphous DCIS Cells -> CAFs, DCIS Associated 0.0051749987898648 0.2510234128936706 0.7373999388878224 0.2461374514707439 0.0009262556366009 0.0455125113141721 0.0 5.978000956480152e-05 0.0135932142330578 0.0 4879 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1056019 VWF SELP VWF-SELP Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0051743826245112 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0019871862905238 0.0053213839468185 0.0 6.438320885912955e-05 0.0294179703317152 0.0 1412 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1056091 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0051731005975108 0.6160088550075702 0.6631822525600675 0.7917001487310438 0.0021291294377375 0.0027830389352876 0.0 3.908387399359025e-05 0.0121656607852329 0.0 1163 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1056132 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells 0.0051721497286423 0.6242573126045354 0.6176321640000088 0.8824495942126559 0.0001959417442809 0.02871400543887 0.0 3.101736972704714e-05 0.0150097758964619 0.0 12090 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1056137 CXCL12 CXCR4 CXCL12-CXCR4 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0051720883144638 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0052742025956585 0.0012252690191386 0.0 5.681818181818182e-05 0.0455893122029905 0.0 800 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1056156 CD48 CD2 CD48-CD2 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0051717534511497 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0164675938709007 0.0003671083100858 0.0 0.0 0.0 0.0 312 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1056233 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0051703990119217 0.6626993710110988 0.6207977546603366 0.7917001487310438 0.0035190936623492 0.0016667952436519 0.0 0.0 0.0 0.0 42 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1056456 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.005166207847164 0.6342079770588467 0.8923034233058523 0.6198216015396206 0.0028649117803088 0.00189193058407 0.0 0.0001020616452337 0.0451517306250755 0.0 1633 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1056592 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0051636524146811 0.7487535481622718 0.6632137581773894 0.6198216015396206 0.0015847932820241 0.0038860320327025 0.0 0.0 0.0 0.0 32 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1056624 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.005163196367054 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0002327631000826 0.0446401662952339 0.0 0.0 0.0 0.0 496 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1056632 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0051630221464445 0.2491449441646273 0.7760344326192508 0.2461374514707439 0.0108445362943651 0.0036702914086929 0.0 0.0 0.0 0.0 902 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1056647 CD34 SELP CD34-SELP Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0051628493258627 0.7168245244832976 0.941479368642921 0.7204611100467462 0.0018206581062216 0.0021392900294222 0.0 0.0014836795252225 0.4799422614079497 0.0 337 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1056656 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.005162735570101 0.6249837837987587 0.7470475610360806 0.6198216015396206 0.0084812136822336 0.0007714919761827 0.0 0.0 0.0 0.0 21 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1056684 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0051622203500725 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0002750231449378 0.0265498740402422 0.0 0.0 0.0 0.0 129 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1056699 THBS2 CD36 THBS2-CD36 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0051619364588528 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.004981832968137 0.0096442330625583 0.0 5.540780141843972e-05 0.056407386072062 0.0 752 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1056790 THBS2 CD36 THBS2-CD36 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0051605416287251 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.004981832968137 0.0011409783203169 0.0 0.0001355748373101 0.1035944118435303 0.0 922 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1056893 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0051587934126619 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0020251995753771 0.0032275631628407 0.0 0.0 0.0 0.0 79 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1056924 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0051583038778736 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0015847932820241 0.0038621268649178 0.0 0.0015151515151515 0.9365429812691404 0.0 30 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1056946 THBS2 CD36 THBS2-CD36 Endothelial Cells Plasma Cells Endothelial Cells -> Plasma Cells 0.0051578393575161 0.9197297916541942 0.7373999388878224 0.7204611100467462 0.0039472834455595 0.0009761781830445 0.0 0.0006153305203938 0.2371752708874981 0.0 474 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1057113 JAG1 NOTCH2 JAG1-NOTCH2 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0051543828274775 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0001109003117737 0.0373075519081129 0.0 0.0 0.0 0.0 50 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1057121 DLL4 NOTCH4 DLL4-NOTCH4 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0051543236675357 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0002327631000826 0.0244129856070659 0.0 0.0 0.0 0.0 50 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1057174 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0051535138898934 0.9184503888425788 0.7746834992804791 0.6198216015396206 0.0004696576149175 0.0090444648829713 0.0 0.0 0.0 0.0 887 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1057185 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0051532617451383 0.6332974881236617 0.8755243548400705 0.6198216015396206 0.0131302879503246 0.0004150165744076 0.0 0.0 0.0 0.0 42 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1057249 MMRN2 CD93 MMRN2-CD93 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0051520508933789 0.8571898293845529 0.4630027772793905 0.7204611100467462 0.0004196880356983 0.0155837683010033 0.0 0.0002401536983669 0.0326601329132349 0.0 1041 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1057433 CCN1 CAV1 CCN1-CAV1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.005148335492545 0.8749036366850302 0.62431395375366 0.6198216015396206 0.0004337320404416 0.0126805820762719 0.0 9.718172983479106e-05 0.0197984046755632 0.0 343 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1057441 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0051481357624492 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0002705513462707 0.0265498740402422 0.0 0.0 0.0 0.0 8 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1057507 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0051468956155359 0.8640667164982425 0.7841656220878274 0.7827641335561659 0.002676946692949 0.001309307002134 0.0 0.0002376425855513 0.0293510480312539 0.0 526 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1057642 VEGFC FLT1 VEGFC-FLT1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0051441599188222 0.8317042416754105 0.4630488285702799 0.2461374514707439 0.0005440770361181 0.0359289752254096 0.0 0.0 0.0 0.0 41 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1057741 VWF LRP1 VWF-LRP1 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0051425272604222 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0019871862905238 0.0032275631628407 0.0 0.000190186382655 0.0090530064119642 0.0 239 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1057821 CCN1 CAV1 CCN1-CAV1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0051407578453661 0.7797135509308979 0.943345641464811 0.7827641335561659 0.0009209869688402 0.0034806998160403 0.0 0.0 0.0 0.0 527 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1057873 MMRN2 CD93 MMRN2-CD93 Plasma Cells 11q13 Invasive Tumor Cells Plasma Cells -> 11q13 Invasive Tumor Cells 0.0051399659760707 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0002165306714062 0.0289462771086338 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1057878 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0051398910955876 0.940547666092272 0.7154802332407408 0.7204611100467462 0.0001298888146421 0.0292771742399634 0.0 1.520542529574552e-05 0.0017419212924926 0.0 10961 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1057958 MMP2 PECAM1 MMP2-PECAM1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0051384358573491 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0024819960935566 0.0026482500471321 0.0 0.0003528225806451 0.322234115359073 0.0 496 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1057965 EFNB2 PECAM1 EFNB2-PECAM1 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0051383064708282 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0014623066995027 0.0032187363284526 0.0 0.0 0.0 0.0 968 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1058131 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0051353210649797 0.6589792304505506 0.6207977546603366 0.7917001487310438 0.0033973231723341 0.0016667952436519 0.0 0.0 0.0 0.0 38 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1058183 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Myeloid Cells 11q13 Invasive Tumor Cells -> Myeloid Cells 0.0051339563733983 0.6242573126045354 0.7763054211764489 0.6198216015396206 0.0034559943126159 0.0017638974017382 0.0 0.0001102292768959 0.0158298327081579 0.0 756 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1058197 COL4A2 CD93 COL4A2-CD93 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0051336072488299 0.8355319038299565 0.4630027772793905 0.7204611100467462 0.001123788079051 0.0058437228618857 0.0 0.0 0.0 0.0 66 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1058320 VEGFC FLT1 VEGFC-FLT1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0051309141075555 0.8317042416754105 0.7472387841445823 0.7827641335561659 0.0005440770361181 0.0068935067166085 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1058323 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0051308499918562 0.9184503888425788 0.8818120773736414 0.8875000050982297 0.0004696576149175 0.0054043611446182 0.0 0.0 0.0 0.0 1424 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1058386 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0051290973404186 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0117842887908422 0.0003375370073613 0.0 2.1786492374727668e-05 0.0161581500396953 0.0 11475 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1058485 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0051271938414128 0.6213271600240247 0.8617632615906476 0.6198216015396206 0.0052560850129547 0.0010414441948928 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1058543 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0051261615891896 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0020251995753771 0.0028784826949613 0.0 9.765625e-05 0.0098978106594702 0.0 1280 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1058555 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0051260134365289 0.250044481781731 0.7779918296243433 0.2461374514707439 0.0070431301838115 0.0053794918117879 0.0 0.0 0.0 0.0 902 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1058574 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0051255830291037 0.250044481781731 0.7154802332407408 0.2461374514707439 0.0070431301838115 0.0058465532256424 0.0 0.0001496781918874 0.0315023590341876 0.0 13362 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1058614 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0051248651021625 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0003521782369754 0.0144359394371152 0.0 0.0001734906315058 0.0153252598507299 0.0 262 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1058682 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.005123546256016 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.000716220684292 0.0079745943515326 0.0 0.0 0.0 0.0 69 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1058696 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0051232866907383 0.7463064942968751 0.4630027772793905 0.7204611100467462 0.0012430446376512 0.0058437228618857 0.0 0.0 0.0 0.0 85 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1058867 C3 LRP1 C3-LRP1 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.0051196887357925 0.8911088195487638 0.8755243548400705 0.8567148457705164 0.0064915662046245 0.0004150165744076 0.0 0.0001111111111111 0.0320255257055161 0.0 225 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1058900 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0051192467939315 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0002750231449378 0.0312252462757311 0.0 0.0006660006660006 0.0362730162597013 0.0 715 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1058929 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0051187827119685 0.9470274865242416 0.4638256179742202 0.7204611100467462 0.0061455194924501 0.0009249287638231 0.0 0.0 0.0 0.0 285 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1059121 CD34 SELP CD34-SELP Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.005114995987538 0.7871981482311898 0.8347297932672282 0.7827641335561659 0.0038506427265089 0.0009042150166242 0.0 0.0 0.0 0.0 23 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1059227 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0051128392751205 0.6630837220165452 0.4630027772793905 0.2461374514707439 0.0048313935743179 0.0048929293424311 0.0 0.0004070004070004 0.1095209857297197 0.0 351 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1059303 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0051112978654089 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.000245041593909 0.0203874717835032 0.0 4.265629265629266e-05 0.0019972856874896 0.0 1332 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1059314 COL4A1 CD93 COL4A1-CD93 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0051110536962369 0.4604235282221027 0.4630027772793905 0.8293805866303694 0.0017253404164066 0.0058437228618857 0.0 0.0008818342151675 0.2149368774482827 0.0 324 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1059324 MMRN2 CD93 MMRN2-CD93 Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.005110898264996 0.893316592628645 0.7779918296243433 0.6198216015396206 0.0007691101630988 0.0053794918117879 0.0 0.0004208754208754 0.0508047717405915 0.0 594 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1059340 A2M LRP1 A2M-LRP1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0051106187323699 0.7741139100414175 0.7346293219749174 0.6198216015396206 0.0015661096645571 0.0032275631628407 0.0 0.0 0.0 0.0 297 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1059346 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0051105099204784 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0018436902762588 0.0053213839468185 0.0 0.0 0.0 0.0 453 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1059377 VWF LRP1 VWF-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.005109998328104 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0019871862905238 0.0028784826949613 0.0 0.0002771618625277 0.0280913473262126 0.0 246 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1059464 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0051082550504562 0.6303682835571691 0.7426180951053148 0.7204611100467462 0.0101610580570933 0.0005184623914895 0.0 0.000180238635954 0.0212019632649253 0.0 1321 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1059621 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.005105092514067 0.8667347161816407 0.6614977577544194 0.7917001487310438 0.0106228227237899 0.0003671083100858 0.0 0.0 0.0 0.0 1163 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1059668 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0051039393372134 0.4648000335061383 0.7769451595923457 0.2461374514707439 0.0357762282281787 0.0005558995075445 0.0 0.0004960317460317 0.0938120175466991 0.0 84 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1059727 THBS2 CD36 THBS2-CD36 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0051028374478872 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0063387366560491 0.0009761781830445 0.0 0.0002337540906965 0.0900990409943291 0.0 713 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1059805 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0051012958029107 0.6332974881236617 0.6207977546603366 1.0 0.0015572459193676 0.0028784826949613 0.0 0.0001391166822867 0.0140999739478863 0.0 1552 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1059859 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0051002957327478 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0037243679732516 0.0014748371602574 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1059893 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.005099763788926 0.7160288858520609 0.4638256179742202 0.8293805866303694 0.0069047442087267 0.0009249287638231 0.0 0.0 0.0 0.0 219 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1059933 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0050988859585488 0.4619393085577573 0.7841656220878274 0.7204611100467462 0.0051428381563772 0.001309307002134 0.0 0.0 0.0 0.0 43 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1060047 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.005096422166303 0.7835752212271604 0.7746834992804791 0.6198216015396206 0.0064863313435223 0.00071798405859 0.0 0.0 0.0 0.0 144 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1060069 CD34 SELP CD34-SELP Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0050958444011287 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0042829523358709 0.0022515473538965 0.0 0.0 0.0 0.0 239 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1060092 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0050951878946057 0.8630183004227985 0.4614667734221426 0.2461374514707439 0.0001109003117737 0.1609352200462838 0.0 0.0024825095915143 0.0521525110776598 0.0 211 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1060152 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0050939621970612 0.8516956437178343 0.7746834992804791 0.6198216015396206 0.000472352586488 0.0090444648829713 0.0 0.0 0.0 0.0 162 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1060165 A2M LRP1 A2M-LRP1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0050936415720625 0.8392912392980421 0.6207977546603366 0.6198216015396206 0.0005164482812395 0.0104714078116759 0.0 0.0002429543245869 0.0333476117688444 0.0 343 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1060265 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0050916776508386 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0014378253178126 0.0038288178384739 0.0 0.0 0.0 0.0 390 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1060589 CCN1 CAV1 CCN1-CAV1 B Cells B Cells B Cells -> B Cells 0.0050850778163248 0.6213271600240247 0.62431395375366 1.0 0.0023088899408624 0.0019304335593669 0.0 0.0001175364362952 0.0290189083852676 0.0 1418 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1060629 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0050844170002107 0.8721681415062816 0.657421674383923 0.6198216015396206 0.0008193633790489 0.0059327142047454 0.0 0.0 0.0 0.0 409 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1060632 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.005084378512622 0.9303167350027568 0.4623922682986163 0.2461374514707439 0.0016860250240652 0.0096770075292062 0.0 0.0 0.0 0.0 1491 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1060769 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Macrophages B Cells -> Macrophages 0.0050819303723837 0.6249837837987587 0.8923034233058523 0.6198216015396206 0.00263399584678 0.00189193058407 0.0 7.824726134585289e-05 0.0295261908735172 0.0 1065 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1060870 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0050798928686767 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0016171311116606 0.0267255153180908 0.0 0.0001466275659824 0.0080184823119042 0.0 155 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1060946 A2M LRP1 A2M-LRP1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0050782916366774 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.0015661096645571 0.0028784826949613 0.0 0.0 0.0 0.0 50 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1061044 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0050761273381114 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0001971810371238 0.0293031867940321 0.0 0.0001317523056653 0.0164888606439644 0.0 345 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1061125 A2M LRP1 A2M-LRP1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0050749496510873 0.4648000335061383 0.2550748532138862 0.2461374514707439 0.0021905373114471 0.0267255153180908 0.0 0.0009225092250922 0.0802466907521352 0.0 271 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1061226 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0050730028715972 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0069047442087267 0.00071798405859 0.0 0.0 0.0 0.0 394 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1061290 THBS2 CD36 THBS2-CD36 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0050716134776134 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0009736808737186 0.0063011237754475 0.0 5.533421868083222e-05 0.0111655939427251 0.0 753 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1061360 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.005070349925044 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0001959417442809 0.0284069116891947 0.0 0.0 0.0 0.0 193 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1061372 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.005070106439374 0.6303642896310324 0.6331674633943454 0.9161861017439124 0.0014431743145616 0.0032187363284526 0.0 0.0006550218340611 0.1905698414647096 0.0 458 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1061513 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0050671214373686 0.6319926036888139 0.8755243548400705 0.6198216015396206 0.011891719340537 0.0004150165744076 0.0 0.0 0.0 0.0 42 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1061544 HSPG2 LRP1 HSPG2-LRP1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0050665063176447 0.7789175740361626 0.2550748532138862 0.2461374514707439 0.0012941512528773 0.0267255153180908 0.0 0.0013164823591363 0.0786958532738063 0.0 211 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1061730 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0050622840532367 0.2491408586098361 0.930308383061206 0.2461374514707439 0.0001826541344284 0.1615013370958009 0.0 0.0 0.0 0.0 9 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1061736 VWF SELP VWF-SELP CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0050621827098566 0.9275752708651288 0.4623922682986163 0.7204611100467462 0.000245041593909 0.0222228052993653 0.0 4.14693417156696e-06 0.0006866886131777 0.0 10961 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1061761 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0050615836002363 0.8840293712888387 0.4630027772793905 0.7204611100467462 0.0061698665784747 0.0009242223287825 0.0 0.0003508771929824 0.0669125572861563 0.0 285 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1061837 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0050601628960371 0.8718210606749883 0.8331580262014722 0.8567148457705164 0.0017670878089588 0.001526625481682 0.0 0.0 0.0 0.0 137 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1061853 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0050599415364805 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0001971810371238 0.0484993884807927 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1061854 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0050599397905861 0.6342079770588467 0.8818120773736414 0.6198216015396206 0.000895875398841 0.0054043611446182 0.0 0.0 0.0 0.0 119 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1061892 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0050591292917822 0.6332974881236617 0.6207977546603366 0.9161861017439124 0.0016171311116606 0.0028784826949613 0.0 0.0002376425855513 0.0240859270800797 0.0 526 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1061942 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0050582527744613 0.6342079770588467 0.7470475610360806 0.6198216015396206 0.0073929685753755 0.0007714919761827 0.0 0.0 0.0 0.0 361 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1061997 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0050572232930602 0.7160288858520609 0.4641352222874551 1.0 0.0012306151710811 0.0040904475843412 0.0 0.0 0.0 0.0 283 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1062234 MMRN2 CD93 MMRN2-CD93 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0050522864080789 0.6301823358791634 0.7779918296243433 0.9318789094584046 0.0003083910058032 0.0118035014556376 0.0 0.0001003009027081 0.0076845245882288 0.0 4985 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1062364 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0050493163397423 0.9197297916541942 0.8765901449012573 0.8567148457705164 0.0055862851962672 0.0004295051170816 0.0 0.0 0.0 0.0 137 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1062400 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0050484356564894 0.2491449441646273 0.7760344326192508 0.2461374514707439 0.0108445362943651 0.0032078747392388 0.0 0.0006877579092159 0.1574516420247819 0.0 727 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1062423 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0050480451677461 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0015572459193676 0.0267255153180908 0.0 0.0004208754208754 0.0230160140434289 0.0 351 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1062443 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0050476939532935 0.8913986641324685 0.930308383061206 0.8875000050982297 0.0054950348959687 0.0004089864655001 0.0 0.0 0.0 0.0 1462 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1062451 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0050475401397088 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0007263013575398 0.0064028969591119 0.0 0.0 0.0 0.0 339 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1062524 VWF LRP1 VWF-LRP1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.005045915329782 0.6332974881236617 0.6207977546603366 0.8693461273411047 0.00023686843287 0.0203874717835032 0.0 6.313131313131313e-05 0.0029559828174846 0.0 360 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1062567 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.005045314337452 0.6342079770588467 0.7480927101953669 0.6198216015396206 0.000895875398841 0.006260692484444 0.0 0.0 0.0 0.0 21 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1062583 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0050450949324265 0.2490567623945399 0.836885603004631 0.2461374514707439 0.011649387573427 0.0027591088867233 0.0 0.0 0.0 0.0 34 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1062635 THBS2 CD36 THBS2-CD36 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0050441224129239 0.8858959974474152 0.2562573700401372 0.2461374514707439 0.0030563796158022 0.0096442330625583 0.0 0.0 0.0 0.0 263 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1062647 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0050439456760122 0.8284725546778968 0.6331674633943454 0.6198216015396206 0.0012187708721425 0.0041555861088636 0.0 0.0 0.0 0.0 10 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1062748 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Macrophages Mast Cells -> Macrophages 0.0050418072582886 0.8516956437178343 0.8818120773736414 0.8567148457705164 0.000472352586488 0.0054043611446182 0.0 0.0 0.0 0.0 165 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1062797 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0050409134998878 0.255669001367946 0.6632137581773894 0.2461374514707439 0.0061207051981986 0.0064230792457803 0.0 0.0017060687301974 0.2294657359540171 0.0 373 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1062845 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0050400607067065 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.002196330917593 0.0040904475843412 0.0 0.0 0.0 0.0 253 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1062856 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0050398263854434 0.6630837220165452 0.7779918296243433 0.7917001487310438 0.0037159398684439 0.001079730675535 0.0 0.0 0.0 0.0 38 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1062860 COL4A2 CD93 COL4A2-CD93 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0050397168518315 0.8355319038299565 0.6587114738285964 0.6198216015396206 0.001123788079051 0.0042738820064046 0.0 0.0 0.0 0.0 144 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1062923 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.005038634593858 0.2491449441646273 0.4623922682986163 0.2461374514707439 0.0108445362943651 0.0053213839468185 0.0 7.4839095943721e-05 0.0293146230096298 0.0 13362 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1063013 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0050369328853409 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0001971810371238 0.0279580382843415 0.0 0.0003469812630117 0.048656694124627 0.0 262 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1063104 COL4A2 CD93 COL4A2-CD93 B Cells Mast Cells B Cells -> Mast Cells 0.0050351991320769 0.7783550150988336 0.8347945881127203 0.6198216015396206 0.0033449520260795 0.0012097093680331 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1063132 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Myoepithelial Cells Dendritic Cells -> Myoepithelial Cells 0.0050346381018098 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0015409900107563 0.0058437228618857 0.0 0.0003541076487252 0.0716596985318526 0.0 1412 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1063180 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0050334911880442 0.6342079770588467 0.7746834992804791 0.8693461273411047 0.0053032910137447 0.00071798405859 0.0 0.0 0.0 0.0 270 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1063187 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0050333809178396 0.6332974881236617 0.7478729882108823 0.6198216015396206 0.0020251995753771 0.0027351735586246 0.0 0.0 0.0 0.0 129 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1063259 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0050319586599344 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.0026436039558049 0.0018097844702233 0.0 0.000203748981255 0.0181267942125602 0.0 409 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1063263 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0050319296455838 0.8840293712888387 0.8817184225858201 1.0 0.0061698665784747 0.0003375370073613 0.0 2.488181139586962e-05 0.0193306276976736 0.0 4019 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1063282 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0050315480585885 0.9184503888425788 0.8818326005152037 1.0 0.0004696576149175 0.0042655619249233 0.0 0.0 0.0 0.0 4019 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1063293 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0050313812040865 0.7487535481622718 0.7462743270426613 0.7827641335561659 0.0016417770622885 0.0022591041672132 0.0 0.0079051383399209 0.8784076948780055 0.0 23 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1063379 COL4A1 CD93 COL4A1-CD93 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0050295850501541 0.7463064942968751 0.6587114738285964 0.6198216015396206 0.0012430446376512 0.0042738820064046 0.0 0.0 0.0 0.0 160 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1063411 C1QB LRP1 C1QB-LRP1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0050290229388886 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0012213774841743 0.0032275631628407 0.0 0.0 0.0 0.0 50 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1063413 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0050289863897343 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0024319941937022 0.0023576674662702 0.0 0.0 0.0 0.0 126 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1063423 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0050286545001758 0.8840293712888387 0.6587114738285964 0.6198216015396206 0.0061698665784747 0.0007261054236978 0.0 0.0 0.0 0.0 409 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1063512 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0050265020851596 0.7296454584598743 0.4638256179742202 1.0 0.0051524613572059 0.0009249287638231 0.0 0.0 0.0 0.0 283 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1063525 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0050261429944132 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.000895875398841 0.0046263543438723 0.0 0.0 0.0 0.0 69 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1063681 THBS2 CD36 THBS2-CD36 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0050231622740224 0.6242573126045354 0.6176321640000088 0.9318789094584046 0.0063387366560491 0.0007053434767499 0.0 4.99001996007984e-05 0.0241095969680616 0.0 5010 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1063687 VWF SELP VWF-SELP Macrophages Macrophages Macrophages -> Macrophages 0.0050230933278026 0.9011206516381156 0.941479368642921 1.0 0.0008850282134344 0.0021392900294222 0.0 0.0 0.0 0.0 2458 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1063780 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0050212599140142 0.8630183004227985 0.8445107771175474 0.909150863993142 0.0001109003117737 0.0218093597373452 0.0 0.0001690798979372 0.0091633415723743 0.0 1549 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1063813 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Macrophages Basal-like Structured DCIS Cells -> Macrophages 0.0050203943030045 0.6332974881236617 0.941479368642921 0.6198216015396206 0.0020251995753771 0.0021392900294222 0.0 0.0 0.0 0.0 475 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1063869 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.005019312598887 0.2451358214448441 0.663300745568453 0.2461374514707439 0.0010709508378277 0.0373075519081129 0.0 0.0 0.0 0.0 2 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1063954 VWF SELP VWF-SELP Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0050175102027827 0.6332974881236617 0.7478729882108823 0.6198216015396206 0.0019871862905238 0.0027351735586246 0.0 0.0 0.0 0.0 161 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1064032 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Myeloid Cells CAFs, DCIS Associated -> Myeloid Cells 0.0050158912641179 0.7158082793127664 0.7769451595923457 0.7204611100467462 0.0071496754272206 0.0005558995075445 0.0 0.0001892505677517 0.0237101670279421 0.0 1321 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1064064 COL4A2 CD93 COL4A2-CD93 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0050153339807157 0.4630253981438691 0.8347945881127203 0.7204611100467462 0.0047240947268779 0.0012097093680331 0.0 0.0 0.0 0.0 48 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1064084 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0050148391610871 0.250044481781731 0.6347970925105053 0.2461374514707439 0.0070431301838115 0.0057802287131517 0.0 0.0001847745750184 0.0317885267364378 0.0 902 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1064099 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0050145925389672 0.7941469661104034 0.7426180951053148 0.6198216015396206 0.0083898580598364 0.0005184623914895 0.0 0.0006660006660006 0.0783434782460599 0.0 143 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1064132 C1QB LRP1 C1QB-LRP1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0050140239419302 0.7753420160918723 0.2550748532138862 0.2461374514707439 0.0012213774841743 0.0267255153180908 0.0 0.0 0.0 0.0 41 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1064133 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0050140204564136 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0065101973396288 0.0005788283879716 0.0 0.0007230657989877 0.7803863307700616 0.0 922 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1064262 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0050112475322995 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0002750231449378 0.0222186841038061 0.0 0.000246184145741 0.00973486086108 0.0 1354 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1064323 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0050100564982425 0.9184503888425788 0.7480927101953669 0.7827641335561659 0.0004696576149175 0.006260692484444 0.0 0.0 0.0 0.0 526 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1064349 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0050096533645678 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.000219642761279 0.0218093597373452 0.0 0.0001342137757019 0.0072737604261596 0.0 887 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1064457 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0050078218528618 0.7789175740361626 0.7769451595923457 0.6198216015396206 0.0075637985935472 0.0005558995075445 0.0 8.62663906142167e-05 0.0127492536277325 0.0 161 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1064499 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.005007010851812 0.785133132759182 0.6331674633943454 0.6198216015396206 0.001039571291679 0.0049190726392343 0.0 0.0 0.0 0.0 144 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1064507 MMRN2 CD93 MMRN2-CD93 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0050068515191622 0.6301823358791634 0.7779918296243433 0.9318789094584046 0.0031934983073077 0.001079730675535 0.0 0.0001497005988023 0.0164427148800771 0.0 5010 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1064619 VWF SELP VWF-SELP Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0050045645359439 0.6332974881236617 0.941479368642921 0.6198216015396206 0.0019871862905238 0.0021392900294222 0.0 2.783499415465123e-05 0.0049857663309007 0.0 1633 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1064625 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0050044896458956 0.7835752212271604 0.4638256179742202 0.7204611100467462 0.0064863313435223 0.0009249287638231 0.0 0.0 0.0 0.0 37 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1064758 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0050017382651361 0.6561647292424944 0.2550748532138862 0.2461374514707439 0.112230917768503 0.0003386430177035 0.0 0.0 0.0 0.0 179 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1064822 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0050000518112161 0.893316592628645 0.6347970925105053 0.6198216015396206 0.0007691101630988 0.0057802287131517 0.0 0.0 0.0 0.0 594 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1064841 VWF SELP VWF-SELP CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0049996898581377 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0016171311116606 0.0053213839468185 0.0 0.0 0.0 0.0 1684 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1064864 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0049992388607862 0.7296454584598743 0.7470475610360806 0.7204611100467462 0.0051524613572059 0.0007714919761827 0.0 0.0 0.0 0.0 43 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1064867 VWF SELP VWF-SELP Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0049992183230502 0.7158082793127664 0.4623922682986163 0.8293805866303694 0.0025256125075084 0.0022515473538965 0.0 0.0 0.0 0.0 219 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1064938 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0049975748584917 0.6303682835571691 0.663300745568453 0.6198216015396206 0.0002705513462707 0.0222186841038061 0.0 0.0013366750208855 0.0528561467905858 0.0 285 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1064979 VWF SELP VWF-SELP Myoepithelial Cells CAFs, Invasive Associated Myoepithelial Cells -> CAFs, Invasive Associated 0.0049966478775545 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0025256125075084 0.002113171886167 0.0 0.0 0.0 0.0 1562 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1064981 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0049966224206514 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0069047442087267 0.0004874986369898 0.0 0.0 0.0 0.0 1538 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1065059 C1QB LRP1 C1QB-LRP1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0049949930552589 0.7452691992612583 0.7346293219749174 0.7204611100467462 0.0012199377895337 0.0032275631628407 0.0 0.0 0.0 0.0 37 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1065084 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Myoepithelial Cells CAFs, Invasive Associated -> Myoepithelial Cells 0.0049945934272595 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.00146889578236 0.0058437228618857 0.0 0.0002969121140142 0.0600852104079429 0.0 1684 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1065224 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0049922526917082 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0104129581710415 0.0004089864655001 0.0 4.508566275924256e-05 0.0818945742338913 0.0 1109 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1065241 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0049918721186334 0.633566764858408 0.7760344326192508 0.8693461273411047 0.0078992851324392 0.0004582650848664 0.0 0.0 0.0 0.0 270 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1065388 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0049891688221497 0.6630837220165452 0.8347945881127203 0.6198216015396206 0.0037159398684439 0.0012097093680331 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1065470 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0049876293493642 0.6630837220165452 0.7461459456652184 0.6198216015396206 0.0048313935743179 0.0010390313650636 0.0 0.0031055900621118 0.2954877052318452 0.0 23 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1065547 A2M LRP1 A2M-LRP1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0049862920502054 0.7741139100414175 0.2550748532138862 0.2461374514707439 0.093381536992618 0.0003386430177035 0.0 0.005 0.8245877061469269 0.0 75 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1065640 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.004984250266967 0.6561647292424944 0.2550748532138862 0.2461374514707439 0.1098969873322313 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1065696 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0049831713513549 0.743507317541692 0.8331580262014722 0.7827641335561659 0.0020684923107111 0.001526625481682 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1065761 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0049821268621737 0.6160088550075702 0.6631822525600675 1.0 0.0009692519480124 0.0038621268649178 0.0 8.786316776007497e-05 0.054309837831329 0.0 1552 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1065842 C1QB LRP1 C1QB-LRP1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0049800955519956 0.7452691992612583 0.2550748532138862 0.2461374514707439 0.0012199377895337 0.0267255153180908 0.0 0.0 0.0 0.0 122 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1066017 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Dendritic Cells CAFs, Invasive Associated -> Dendritic Cells 0.0049761468118108 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.00146889578236 0.003263637675389 0.0 0.0005700441784238 0.0574452850313037 0.0 2339 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1066019 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Macrophages T Lymphocytes -> Macrophages 0.004976053768278 0.6301823358791634 0.9195415044619336 0.6198216015396206 0.0031934983073077 0.0013235329769289 0.0 4.8435532306500046e-05 0.0130636379701518 0.0 3441 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1066186 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0049723513723225 0.6303682835571691 0.663300745568453 0.6198216015396206 0.000219642761279 0.0265498740402422 0.0 0.0005239259517988 0.0133103333219603 0.0 409 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1066203 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0049719979779864 0.6332974881236617 0.6252253442669611 0.9592803095773328 0.0003521782369754 0.0112932915661816 0.0 6.159152500615915e-05 0.0023077076126448 0.0 1476 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1066218 CD34 SELP CD34-SELP Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0049715988177506 0.2491449441646273 0.8819126042133903 0.2461374514707439 0.0003767662344862 0.0741032966028748 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1066346 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0049689099656711 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0016171311116606 0.0032275631628407 0.0 0.0003144089112468 0.0149660866869725 0.0 253 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1066357 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0049686745544339 0.7160288858520609 0.8341464445360613 0.7204611100467462 0.0186793449598515 0.0001871866311057 0.0 0.0 0.0 0.0 1082 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1066372 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0049683449791286 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0015572459193676 0.0053213839468185 0.0 0.0 0.0 0.0 714 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1066377 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0049681779801209 0.4630253981438691 0.8817184225858201 0.2461374514707439 0.0443339118517084 0.0003375370073613 0.0 7.225433526011561e-05 0.0561342432925941 0.0 1384 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1066417 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0049676156672151 0.2490567623945399 0.6571792026963191 0.2461374514707439 0.011649387573427 0.0032020139126304 0.0 0.0 0.0 0.0 26 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1066626 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0049636311098822 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.000716220684292 0.0053794918117879 0.0 0.0006318449873631 0.0762713590916042 0.0 1187 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1066638 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0049634044380984 0.8818165186409654 0.6207977546603366 0.6198216015396206 0.0026436039558049 0.0016667952436519 0.0 0.0001931451046495 0.0244357464919112 0.0 791 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1066655 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0049631424694779 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0055862851962672 0.0007598956708367 0.0 0.0 0.0 0.0 409 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1066665 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0049629285758942 0.6332974881236617 0.950463483645931 0.6198216015396206 0.0020251995753771 0.0019776346124415 0.0 0.000163947864579 0.0687836302821271 0.0 1109 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1066698 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.004962214501519 0.8721681415062816 0.8381155706134242 0.8567148457705164 0.0008193633790489 0.0029095741067474 0.0 0.0 0.0 0.0 137 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1066743 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.004960947310599 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0083565457974945 0.0004582650848664 0.0 0.0 0.0 0.0 42 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1066854 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0049590343384988 0.4648000335061383 0.8755243548400705 0.2461374514707439 0.0357762282281787 0.0004150165744076 0.0 0.0012254901960784 0.17825311942959 0.0 34 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1066882 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0049585097169698 0.633566764858408 0.6572093097629401 0.9161861017439124 0.0018436902762588 0.002113171886167 0.0 0.0 0.0 0.0 408 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1066933 VWF SELP VWF-SELP Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0049571417541763 0.9011206516381156 0.6572093097629401 0.6198216015396206 0.0008850282134344 0.0045674276780054 0.0 0.0 0.0 0.0 129 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1066969 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Mast Cells Macrophages -> Mast Cells 0.004956458130392 0.8913986641324685 0.8537710813834968 0.8567148457705164 0.0054950348959687 0.0004138063814779 0.0 0.0003787878787878 0.0330979699911738 0.0 165 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1067009 HSPG2 LRP1 HSPG2-LRP1 B Cells Plasma Cells B Cells -> Plasma Cells 0.004955815877164 0.7789175740361626 0.7346293219749174 0.6198216015396206 0.0012941512528773 0.0032275631628407 0.0 0.0006546950991395 0.0359981662982968 0.0 297 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1067021 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0049555739357107 0.633566764858408 0.7478729882108823 0.6198216015396206 0.0018436902762588 0.0027351735586246 0.0 0.0 0.0 0.0 21 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1067041 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0049551667860041 0.7800321422220979 0.6331674633943454 0.8693461273411047 0.0014623066995027 0.0023576674662702 0.0 0.0 0.0 0.0 360 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1067079 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0049543608472451 0.6249837837987587 0.8341464445360613 0.6198216015396206 0.0244483651952677 0.0001871866311057 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1067141 VWF SELP VWF-SELP T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0049533872967546 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0036144684673052 0.0022515473538965 0.0 0.000127502231289 0.0123037576610359 0.0 713 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1067173 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0049528569099067 0.6160088550075702 0.6632137581773894 0.9592803095773328 0.0009692519480124 0.0038860320327025 0.0 0.0001216175129218 0.0687964913789397 0.0 1495 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1067208 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0049521625346228 0.8516956437178343 0.7480927101953669 0.7827641335561659 0.000472352586488 0.006260692484444 0.0 0.0 0.0 0.0 23 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1067277 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0049507081889457 0.6582846571368821 0.4630027772793905 0.6198216015396206 0.0084325366891025 0.0009242223287825 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1067307 CD34 SELP CD34-SELP Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0049500076804834 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0042829523358709 0.0010419094417808 0.0 0.0 0.0 0.0 209 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1067313 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0049498837028894 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0036991419150414 0.0104714078116759 0.0 0.0007120253164556 0.0700663407656173 0.0 316 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1067321 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0049498265231869 0.7789175740361626 0.7769451595923457 0.6198216015396206 0.0070532058552773 0.0005558995075445 0.0 0.0003847337642351 0.0568595521901646 0.0 361 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1067333 THBS2 CD36 THBS2-CD36 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0049495938278935 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0063387366560491 0.0007598956708367 0.0 0.0 0.0 0.0 81 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1067345 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0049493483306382 0.6630837220165452 0.6587114738285964 0.9592803095773328 0.0048313935743179 0.0007261054236978 0.0 0.0001911132345914 0.0255543898201004 0.0 1495 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1067353 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0049491705416373 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0085570823799139 0.0004874986369898 0.0 0.0 0.0 0.0 339 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1067359 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0049490870006515 0.6659645551150886 0.7464347811605867 0.6198216015396206 0.0037243679732516 0.0012805120781881 0.0 0.0 0.0 0.0 21 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1067406 CCN1 CAV1 CCN1-CAV1 Mast Cells Macrophages Mast Cells -> Macrophages 0.0049481244069471 0.8749036366850302 0.8818704453527788 0.8567148457705164 0.0004337320404416 0.0051192928876727 0.0 0.0002020202020202 0.0380595392953263 0.0 165 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1067454 VWF ITGA9 VWF-ITGA9 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0049472800035803 0.6332974881236617 0.950463483645931 0.6198216015396206 0.0019871862905238 0.0019776346124415 0.0 0.0 0.0 0.0 922 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1067464 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0049470986185075 0.7160288858520609 0.836885603004631 0.7204611100467462 0.0012306151710811 0.0027591088867233 0.0 0.0 0.0 0.0 48 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1067496 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0049465674412161 0.7840818683779507 0.7470475610360806 1.0 0.0032417203409647 0.0007714919761827 0.0 0.0016195524146054 0.469809990166768 0.0 1132 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1067509 CD34 SELP CD34-SELP Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0049462395156744 0.8963354148873306 0.6572093097629401 0.6198216015396206 0.0038492365148421 0.0010419094417808 0.0 0.0 0.0 0.0 129 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1067570 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (Mitotic) 0.0049450547495683 0.6301823358791634 0.6587114738285964 0.9161861017439124 0.00146889578236 0.0026174949623928 0.0 0.0 0.0 0.0 526 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1067579 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.004944871003657 0.8911088195487638 0.7769451595923457 0.7827641335561659 0.0048525806497539 0.0005558995075445 0.0 0.0001425855513307 0.0319654327439632 0.0 526 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1067608 VWF ITGA9 VWF-ITGA9 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.004944378345415 0.9011206516381156 0.6252253442669611 0.6198216015396206 0.0008850282134344 0.0047273851759697 0.0 0.0014094432699083 0.0660905003780592 0.0 129 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1067622 C3 LRP1 C3-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0049440777198176 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.0029337538459309 0.0018097844702233 0.0 0.0 0.0 0.0 8 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1067688 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.004942788070496 0.633566764858408 0.941479368642921 0.6198216015396206 0.0018436902762588 0.0021392900294222 0.0 0.0 0.0 0.0 119 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1067713 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0049423827136262 0.6342079770588467 0.8923034233058523 0.6198216015396206 0.002196330917593 0.00189193058407 0.0 0.0 0.0 0.0 1361 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1067812 CD48 CD2 CD48-CD2 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0049403618347325 0.7719609236370527 0.7763428264267787 0.8567148457705164 0.0112468593062777 0.0002517784065132 0.0 0.0 0.0 0.0 148 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1067845 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0049394981923388 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0097699360831605 0.0004089864655001 0.0 1.0245901639344262e-05 0.0186108776281527 0.0 4880 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1067857 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0049392020381177 0.4604235282221027 0.8347945881127203 0.2461374514707439 0.0126864732057784 0.0012097093680331 0.0 0.0 0.0 0.0 34 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1067865 COL4A2 CD93 COL4A2-CD93 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0049391249526625 0.7783550150988336 0.4630027772793905 0.2461374514707439 0.0033449520260795 0.0048929293424311 0.0 0.0 0.0 0.0 211 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1067932 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0049377580570327 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0015572459193676 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1067933 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0049377496610001 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0033537993821664 0.0112932915661816 0.0 0.0 0.0 0.0 373 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1068061 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells 0.0049346550915597 0.940547666092272 0.6587114738285964 0.6198216015396206 0.0001298888146421 0.0289462771086338 0.0 0.0001759633996128 0.0363880422299083 0.0 5683 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1068078 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0049343527181447 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0069047442087267 0.0006074333625108 0.0 0.0 0.0 0.0 394 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1068088 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0049341846071954 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0085570823799139 0.0009249287638231 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1068192 CCN1 CAV1 CCN1-CAV1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0049317222994143 0.7324582304061453 0.7832252605020791 0.7204611100467462 0.0025580826958339 0.00136079311934 0.0 0.0 0.0 0.0 43 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1068214 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0049313329144345 0.7797135509308979 0.252518874138558 0.2461374514707439 0.0009209869688402 0.0322196586137726 0.0 0.0010928961748633 0.1912526218177188 0.0 122 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1068227 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0049309584044984 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.000219642761279 0.0312252462757311 0.0 0.0002653927813163 0.0144543349028507 0.0 1884 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1068228 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0049309469656251 0.6303642896310324 0.8537710813834968 0.6198216015396206 0.0104129581710415 0.0004138063814779 0.0 0.0 0.0 0.0 18 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1068229 CD34 SELP CD34-SELP Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0049309308326952 0.7168245244832976 0.4623922682986163 0.2461374514707439 0.0018206581062216 0.0096770075292062 0.0 0.0 0.0 0.0 271 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1068241 VWF LRP1 VWF-LRP1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0049307819391382 0.7848266128497919 0.9078204025796472 0.7827641335561659 0.0004024409845247 0.0064028969591119 0.0 0.0001293772641021 0.0134876228358246 0.0 527 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1068466 VEGFC FLT1 VEGFC-FLT1 Macrophages B Cells Macrophages -> B Cells 0.0049261804247881 0.8963332422588541 0.777821334064334 0.6198216015396206 0.0026007495851186 0.001271575589586 0.0 0.0 0.0 0.0 1074 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1068492 HSPG2 LRP1 HSPG2-LRP1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0049255488564625 0.9253089325030373 0.6207977546603366 0.6198216015396206 0.0022161183602947 0.0018097844702233 0.0 0.0 0.0 0.0 129 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1068547 HSPG2 LRP1 HSPG2-LRP1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0049244679832034 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0012941512528773 0.0028784826949613 0.0 0.0 0.0 0.0 50 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1068639 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0049224874103391 0.8913986641324685 0.6331674633943454 0.6198216015396206 0.0054950348959687 0.0007400708115376 0.0 0.0 0.0 0.0 129 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1068649 VWF SELP VWF-SELP CAFs, Invasive Associated CAFs, Invasive Associated CAFs, Invasive Associated -> CAFs, Invasive Associated 0.0049222769778593 0.6332974881236617 0.6572093097629401 1.0 0.0016171311116606 0.002113171886167 0.0 9.43930526713234e-05 0.0188971098777309 0.0 5297 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1068674 THBS2 CD36 THBS2-CD36 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.004921757015757 0.724503440376099 0.8587566561291643 0.7204611100467462 0.0027791828709671 0.0011409783203169 0.0 2.70914607715648e-05 0.0207009206154605 0.0 1538 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1068700 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0049212621184669 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0003521782369754 0.0222228052993653 0.0 0.0 0.0 0.0 77 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1068859 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0049182538097965 0.7451589345683471 0.2491073778594529 0.2461374514707439 0.0040724665904272 0.0076066460958003 0.0 0.0005122950819672 0.2134260425758494 0.0 122 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1068901 VWF SELP VWF-SELP Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0049173590160329 0.9011206516381156 0.4623922682986163 0.7204611100467462 0.0008850282134344 0.0053213839468185 0.0 6.357279084551812e-05 0.0290476742016656 0.0 715 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1068929 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0049166345316154 0.6332974881236617 0.4623922682986163 0.2461374514707439 0.0020251995753771 0.0096770075292062 0.0 0.0001036591686534 0.0295719618541706 0.0 877 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1068996 VWF SELP VWF-SELP Basal-like Structured DCIS Cells CAFs, Invasive Associated Basal-like Structured DCIS Cells -> CAFs, Invasive Associated 0.004915260182323 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0020251995753771 0.002113171886167 0.0 9.738520718702828e-05 0.0194961271894319 0.0 1867 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1069014 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0049148501952572 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.0084812136822336 0.0009249287638231 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1069057 VWF SELP VWF-SELP Macrophages Basal-like Structured DCIS Cells Macrophages -> Basal-like Structured DCIS Cells 0.0049139688835173 0.9011206516381156 0.7760344326192508 0.6198216015396206 0.0008850282134344 0.0036702914086929 0.0 0.0 0.0 0.0 594 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1069081 VWF LRP1 VWF-LRP1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0049135554009889 0.8525936146535493 0.6207977546603366 0.6198216015396206 0.0002103933337194 0.0203874717835032 0.0 0.0 0.0 0.0 30 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1069099 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0049132578691537 0.4629984640915818 0.7346293219749174 1.0 0.0012814156885439 0.0032275631628407 0.0 0.0009815469179426 0.0539699918757907 0.0 283 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1069116 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0049129917099308 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0016417770622885 0.0027830389352876 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1069172 THBS2 CD36 THBS2-CD36 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0049117898390114 0.8858959974474152 0.7373999388878224 0.7204611100467462 0.0030563796158022 0.0009761781830445 0.0 0.0007668711656441 0.2955856574951993 0.0 326 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1069282 CCN1 CAV1 CCN1-CAV1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0049091277800568 0.7324582304061453 0.62431395375366 0.6198216015396206 0.0025580826958339 0.0019304335593669 0.0 0.0003174603174603 0.0783786896958277 0.0 315 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1069442 VWF ITGA9 VWF-ITGA9 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0049057614616183 0.2486570577556728 0.7292496872084557 0.2461374514707439 0.0001077515101466 0.2898144908728011 0.0 0.0005821286504317 0.0135198442569549 0.0 937 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1069576 CCN1 CAV1 CCN1-CAV1 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0049030287762062 0.8749036366850302 0.62431395375366 0.6198216015396206 0.0004337320404416 0.009460730808256 0.0 0.0008230452674897 0.1021860342898762 0.0 162 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1069615 THBS2 CD36 THBS2-CD36 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0049020323609634 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.004981832968137 0.0009761781830445 0.0 0.0 0.0 0.0 239 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1069623 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0049019016822442 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0055862851962672 0.0007053434767499 0.0 0.0 0.0 0.0 791 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1069660 COL4A1 CD93 COL4A1-CD93 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0049012108637666 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.0017253404164066 0.0042738820064046 0.0 0.0015037593984962 0.1086821421562281 0.0 285 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1069664 VWF SELP VWF-SELP Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0049011319287001 0.6332974881236617 0.4623922682986163 0.2461374514707439 0.0019871862905238 0.0096770075292062 0.0 0.0 0.0 0.0 752 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1069683 VWF ITGA9 VWF-ITGA9 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0049005965726702 0.2486570577556728 0.7292496872084557 0.2461374514707439 0.0001077515101466 0.2879885658616873 0.0 0.0010214504596527 0.0376420799122084 0.0 89 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1069720 VWF SELP VWF-SELP Dendritic Cells CAFs, Invasive Associated Dendritic Cells -> CAFs, Invasive Associated 0.004899761912858 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0019871862905238 0.002113171886167 0.0 3.853713052526109e-05 0.0077149786906887 0.0 2359 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1069771 VWF ITGA9 VWF-ITGA9 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0048989366529439 0.7848266128497919 0.6252253442669611 0.6198216015396206 0.0004024409845247 0.0112932915661816 0.0 0.0 0.0 0.0 30 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1069775 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0048988828025619 0.2490567623945399 0.7746834992804791 0.2461374514707439 0.000126812416921 0.2295016807597237 0.0 0.0002436647173489 0.0121127276466739 0.0 684 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1069806 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0048980490511471 0.8284725546778968 0.7167436199046466 0.7204611100467462 0.0012187708721425 0.0026482500471321 0.0 0.0 0.0 0.0 66 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1069895 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0048959209277292 0.6342079770588467 0.7754072541855492 0.8693461273411047 0.0053032910137447 0.0006074333625108 0.0 0.0 0.0 0.0 270 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1069956 THBS2 CD36 THBS2-CD36 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0048947337871677 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0008527942416386 0.0056518532344078 0.0 0.0 0.0 0.0 496 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1069997 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0048939729246341 0.6630837220165452 0.4630027772793905 0.2461374514707439 0.0037159398684439 0.0048929293424311 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1070014 C1QB LRP1 C1QB-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0048936200014611 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0026949121497638 0.0028784826949613 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1070025 VWF ITGA9 VWF-ITGA9 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0048935029492187 0.7848266128497919 0.7831795333113832 1.0 0.0004024409845247 0.0055509879377996 0.0 0.0008833922261484 0.0658804936710792 0.0 1132 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1070099 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0048919545257924 0.6160088550075702 0.7462743270426613 0.6198216015396206 0.0021291294377375 0.0022591041672132 0.0 0.0 0.0 0.0 129 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1070137 HSPG2 LRP1 HSPG2-LRP1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0048911588945078 0.8349903778527206 0.6207977546603366 0.6198216015396206 0.0014804857410621 0.0028784826949613 0.0 0.0083333333333333 0.6161718619896147 0.0 10 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1070196 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0048897562291418 0.2490567623945399 0.8818326005152037 0.2461374514707439 0.000126812416921 0.1993723722552783 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1070206 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0048894622716287 0.7856500335676843 0.6347970925105053 0.6198216015396206 0.0005542667491398 0.0079745943515326 0.0 0.0 0.0 0.0 388 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1070317 VWF LRP1 VWF-LRP1 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0048870859818992 0.9011206516381156 0.7346293219749174 0.7204611100467462 0.0008850282134344 0.0032275631628407 0.0 0.0002788622420524 0.0132740400764384 0.0 326 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1070391 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0048858776625867 0.2491449441646273 0.7478729882108823 0.2461374514707439 0.0108445362943651 0.0027351735586246 0.0 0.0 0.0 0.0 84 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1070425 CD34 SELP CD34-SELP Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0048849059459962 0.7168245244832976 0.4623922682986163 1.0 0.0018206581062216 0.0022515473538965 0.0 0.0 0.0 0.0 283 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1070451 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0048841514258935 0.7487535481622718 0.6631822525600675 0.6198216015396206 0.0015847932820241 0.0027830389352876 0.0 0.0 0.0 0.0 32 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1070513 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0048831417168534 0.2490567623945399 0.4641352222874551 0.2461374514707439 0.011649387573427 0.0040904475843412 0.0 0.0 0.0 0.0 272 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1070667 CD34 SELP CD34-SELP CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0048797861450015 0.9303167350027568 0.6572093097629401 0.6198216015396206 0.0016860250240652 0.002113171886167 0.0 0.0 0.0 0.0 1422 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1070702 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0048788403006278 0.6303642896310324 0.8537710813834968 0.6198216015396206 0.0097699360831605 0.0004138063814779 0.0 0.0 0.0 0.0 42 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1070732 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0048782004892487 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0031934983073077 0.0109188419829382 0.0 0.0 0.0 0.0 383 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1070781 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0048773150230404 0.8911088195487638 0.8755243548400705 0.8567148457705164 0.0048525806497539 0.0004150165744076 0.0 0.0001824817518248 0.0525966663046798 0.0 137 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1070798 C3 LRP1 C3-LRP1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0048767207672501 0.7148920381722296 0.6207977546603366 0.6198216015396206 0.0029337538459309 0.0016667952436519 0.0 0.0007142857142857 0.131193046289581 0.0 315 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1070897 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0048748080713632 0.7800321422220979 0.7167436199046466 0.6198216015396206 0.0014623066995027 0.0026482500471321 0.0 0.0 0.0 0.0 496 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1070945 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Mast Cells CAFs, DCIS Associated -> Mast Cells 0.0048734860219787 0.7158082793127664 0.8755243548400705 0.7204611100467462 0.0071496754272206 0.0004150165744076 0.0 0.0001470341119139 0.0179897139955291 0.0 1082 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1070955 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0048732716205702 0.2491449441646273 0.941479368642921 0.2461374514707439 0.0108445362943651 0.0021392900294222 0.0 0.0022522522522522 0.7285610004255814 0.0 222 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1070958 MMRN2 CD93 MMRN2-CD93 Macrophages Myoepithelial Cells Macrophages -> Myoepithelial Cells 0.0048731975654162 0.893316592628645 0.4630027772793905 0.7204611100467462 0.0007691101630988 0.0058437228618857 0.0 0.0 0.0 0.0 715 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1070993 VWF LRP1 VWF-LRP1 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0048725103101099 0.9011206516381156 0.2550748532138862 0.2461374514707439 0.0008850282134344 0.0267255153180908 0.0 0.0005184929139301 0.0283543290877223 0.0 263 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071087 JAG1 NOTCH2 JAG1-NOTCH2 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0048702841261704 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0001109003117737 0.0265498740402422 0.0 0.0 0.0 0.0 42 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1071094 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0048701845905362 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0033537993821664 0.0104714078116759 0.0 0.0002517261219792 0.0211339301656143 0.0 316 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071156 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.004868689019987 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0004094805141934 0.0104714078116759 0.0 0.0 0.0 0.0 69 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1071172 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0048682185630683 0.785133132759182 0.6331674633943454 0.6198216015396206 0.001039571291679 0.0041555861088636 0.0 0.0 0.0 0.0 30 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071194 VWF ITGA9 VWF-ITGA9 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.004867801256319 0.9011206516381156 0.950463483645931 0.8875000050982297 0.0008850282134344 0.0019776346124415 0.0 0.0 0.0 0.0 1462 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1071209 CD34 SELP CD34-SELP Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0048674879621997 0.8532069650852002 0.6572093097629401 0.6198216015396206 0.00083777361258 0.0045674276780054 0.0 0.0 0.0 0.0 10 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1071262 VWF SELP VWF-SELP Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0048663403796403 0.8525936146535493 0.4623922682986163 0.7204611100467462 0.0002103933337194 0.0222228052993653 0.0 8.732861758798359e-05 0.0144606991143924 0.0 1041 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1071268 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0048661046079308 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0061207051981986 0.0044430418127202 0.0 0.0013368983957219 0.049974751132774 0.0 34 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1071285 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0048656457078866 0.7789175740361626 0.8755243548400705 0.6198216015396206 0.0075637985935472 0.0004150165744076 0.0 0.0002759381898454 0.0383543429901046 0.0 151 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071295 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0048655311101778 0.7719609236370527 0.4603649459881741 0.2461374514707439 0.0014378253178126 0.0105486447632276 0.0 0.0 0.0 0.0 1491 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1071339 MMRN2 CD93 MMRN2-CD93 Dendritic Cells 11q13 Invasive Tumor Cells (Mitotic) Dendritic Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0048648418428713 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0015409900107563 0.0026174949623928 0.0 0.0 0.0 0.0 246 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1071371 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.004864285429735 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.000895875398841 0.0042655619249233 0.0 0.000438596491228 0.0952659212583029 0.0 380 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1071400 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0048637804667933 0.6303642896310324 0.6331674633943454 0.9592803095773328 0.0008320501336843 0.0041555861088636 0.0 0.0001185636856368 0.0225269118697178 0.0 1476 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071433 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0048631109057808 0.7482742921073442 0.4630027772793905 0.7204611100467462 0.005733874009046 0.0009242223287825 0.0 0.0 0.0 0.0 37 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1071474 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0048621756000591 0.9275752708651288 0.9078204025796472 1.0 0.000245041593909 0.0064028969591119 0.0 2.2619828541699653e-05 0.002358124652726 0.0 4019 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071672 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0048584594127179 0.2485046029682279 0.9078204025796472 0.2461374514707439 0.0036991419150414 0.0064028969591119 0.0 7.225433526011561e-05 0.0136888751280731 0.0 1384 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1071674 HSPG2 LRP1 HSPG2-LRP1 Macrophages B Cells Macrophages -> B Cells 0.0048584443367734 0.9253089325030373 0.6207977546603366 0.6198216015396206 0.0022161183602947 0.0016667952436519 0.0 0.0001034554107179 0.0130886578466916 0.0 1074 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071735 COL4A1 CD93 COL4A1-CD93 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0048571268281106 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.0002970267018348 0.0118035014556376 0.0 0.0 0.0 0.0 343 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1071744 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0048567316456839 0.7856500335676843 0.7154802332407408 0.7204611100467462 0.0005542667491398 0.0058465532256424 0.0 0.0 0.0 0.0 85 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1071745 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells -> Luminal-like Amorphous DCIS Cells 0.0048567232989411 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0034559943126159 0.0096442330625583 0.0 0.0 0.0 0.0 184 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071780 CD34 SELP CD34-SELP Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0048561098425531 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.0082993421103349 0.0004582650848664 0.0 0.0 0.0 0.0 394 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1071786 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0048559786233966 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.000716220684292 0.0057802287131517 0.0 0.0001404099971918 0.0241560666522888 0.0 1187 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1071811 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0048554109418377 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0034559943126159 0.0011409783203169 0.0 8.538251366120219e-06 0.0065241835874135 0.0 4880 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1071912 CD48 CD2 CD48-CD2 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.004853309852464 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0112468593062777 0.0003671083100858 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1071935 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0048529200563772 0.7856500335676843 0.6347970925105053 0.6198216015396206 0.0005542667491398 0.0076236123034427 0.0 0.0010416666666666 0.0928324249336939 0.0 160 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1072120 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0048488440023947 0.7487535481622718 0.7754239189773715 0.8567148457705164 0.0016417770622885 0.0015914585039484 0.0 0.0003071253071253 0.1491062977822338 0.0 148 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1072154 VWF SELP VWF-SELP CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0048481136194145 0.6332974881236617 0.7478729882108823 0.6198216015396206 0.0016171311116606 0.0027351735586246 0.0 0.0009535918626827 0.0523412337909171 0.0 143 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1072214 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0048468540340447 0.8516956437178343 0.8818326005152037 0.8567148457705164 0.000472352586488 0.0042655619249233 0.0 0.0 0.0 0.0 148 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1072229 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells B Cells Plasma Cells -> B Cells 0.0048466302884652 0.7296454584598743 0.7746834992804791 0.6198216015396206 0.0051524613572059 0.00071798405859 0.0 0.0 0.0 0.0 315 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1072255 A2M LRP1 A2M-LRP1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0048461011882941 0.7460047258226694 0.7346293219749174 0.7204611100467462 0.0010163752993685 0.0032275631628407 0.0 0.0011261261261261 0.066504565072695 0.0 37 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1072312 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0048449016090077 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0008320501336843 0.0049190726392343 0.0 0.0006578947368421 0.0803626532774999 0.0 38 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1072316 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0048448392256525 0.718867305289982 0.7841656220878274 0.7204611100467462 0.0024319941937022 0.001309307002134 0.0 0.0 0.0 0.0 43 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1072334 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0048444238140811 0.7800321422220979 0.2491073778594529 0.2461374514707439 0.1357656553382984 0.0001990509171164 0.0 0.000450288184438 0.7412615201210475 0.0 694 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1072438 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0048424574661189 0.7158082793127664 0.2531744428854943 0.2461374514707439 0.0071496754272206 0.0040430820937484 0.0 0.000395256916996 1.0 0.0 230 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1072519 CD34 SELP CD34-SELP Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0048406516688905 0.7871981482311898 0.6572093097629401 0.6198216015396206 0.0038506427265089 0.0010419094417808 0.0 0.015625 1.0 0.0 32 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1072520 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.004840632237853 0.633566764858408 0.4623922682986163 0.2461374514707439 0.0018436902762588 0.0096770075292062 0.0 0.0 0.0 0.0 19 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1072559 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0048395485686667 0.6589792304505506 0.7769451595923457 0.6198216015396206 0.0072827533047186 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1072744 VWF SELP VWF-SELP CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0048356050123212 0.6332974881236617 0.941479368642921 0.6198216015396206 0.0016171311116606 0.0021392900294222 0.0 0.0 0.0 0.0 1361 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1072779 VWF SELP VWF-SELP Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0048346499800317 0.9011206516381156 0.7478729882108823 0.7827641335561659 0.0008850282134344 0.0027351735586246 0.0 0.0002539360081259 0.013938168402423 0.0 179 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1072817 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0048337878306709 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0009692519480124 0.0044430418127202 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1072823 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0048336956716976 0.8284725546778968 0.6331674633943454 0.6198216015396206 0.0012187708721425 0.0032187363284526 0.0 0.0 0.0 0.0 144 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1072919 VWF LRP1 VWF-LRP1 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.004831902675347 0.7848266128497919 0.6207977546603366 0.6198216015396206 0.0004024409845247 0.0104714078116759 0.0 0.0001171508903467 0.0098355256735407 0.0 388 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1072932 A2M LRP1 A2M-LRP1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0048316477531305 0.7460047258226694 0.2550748532138862 0.2461374514707439 0.0010163752993685 0.0267255153180908 0.0 0.0003415300546448 0.0297088158385637 0.0 122 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1072939 COL4A2 CD93 COL4A2-CD93 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0048314730077888 0.7482742921073442 0.6587114738285964 0.6198216015396206 0.005733874009046 0.0007261054236978 0.0 0.0 0.0 0.0 32 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1073018 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0048300091903536 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0073929685753755 0.0004874986369898 0.0 0.0 0.0 0.0 1880 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1073021 CD34 SELP CD34-SELP Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0048298943801287 0.633566764858408 0.8347297932672282 0.6198216015396206 0.0042829523358709 0.0009042150166242 0.0 0.0 0.0 0.0 151 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1073096 CD34 SELP CD34-SELP Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0048284247260408 0.8532069650852002 0.4623922682986163 0.7204611100467462 0.00083777361258 0.0053213839468185 0.0 0.0 0.0 0.0 66 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1073156 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0048269314082897 0.6303682835571691 0.663300745568453 0.6198216015396206 0.000219642761279 0.0222186841038061 0.0 0.0002511553144464 0.0099314358091488 0.0 1422 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1073165 VWF ITGA9 VWF-ITGA9 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0048266643241436 0.7848266128497919 0.2531744428854943 0.2461374514707439 0.0004024409845247 0.0642389143033604 0.0 0.0022354694485842 0.1046285935948315 0.0 122 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1073229 CD34 SELP CD34-SELP Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0048250959067276 0.8532069650852002 0.7760344326192508 0.6198216015396206 0.00083777361258 0.0036702914086929 0.0 0.0 0.0 0.0 30 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1073297 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0048236694968194 0.6301823358791634 0.8347945881127203 0.6198216015396206 0.0031934983073077 0.0012097093680331 0.0 0.0007507507507507 0.0398393676695564 0.0 333 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1073311 VWF LRP1 VWF-LRP1 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0048231993589144 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0025256125075084 0.0018097844702233 0.0 0.0002692804825506 0.0279740392012009 0.0 422 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1073431 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0048205731403729 0.6332974881236617 0.6572093097629401 0.9161861017439124 0.0015572459193676 0.002113171886167 0.0 0.0 0.0 0.0 458 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1073443 A2M LRP1 A2M-LRP1 B Cells B Cells B Cells -> B Cells 0.0048203377695852 0.7741139100414175 0.6207977546603366 1.0 0.0015661096645571 0.0016667952436519 0.0 0.0001763046544428 0.0354033250816238 0.0 1418 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1073548 COL4A2 CD93 COL4A2-CD93 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.004818169171472 0.7783550150988336 0.7461459456652184 0.6198216015396206 0.0033449520260795 0.0010390313650636 0.0 0.0 0.0 0.0 137 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1073568 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0048177190271229 0.6332974881236617 0.7478729882108823 0.6198216015396206 0.0015572459193676 0.0027351735586246 0.0 0.0 0.0 0.0 23 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1073664 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0048153840727766 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0073929685753755 0.0009249287638231 0.0 0.0 0.0 0.0 713 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1073842 VWF SELP VWF-SELP T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0048116275210274 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0036144684673052 0.0010419094417808 0.0 0.0 0.0 0.0 81 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1073892 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0048105303046657 0.7719609236370527 0.7763428264267787 0.8875000050982297 0.0014378253178126 0.0016204239758814 0.0 0.0 0.0 0.0 1424 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1073923 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0048098631502102 0.6561647292424944 0.7769451595923457 0.6198216015396206 0.0070489045197697 0.0005558995075445 0.0 0.0 0.0 0.0 21 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1073947 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0048092969129013 0.7789175740361626 0.8755243548400705 0.6198216015396206 0.0070532058552773 0.0004150165744076 0.0 0.0003336670003336 0.0463784247568031 0.0 333 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1073984 VEGFC FLT1 VEGFC-FLT1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0048083808643907 0.8317042416754105 0.6593689120110077 0.6198216015396206 0.0005440770361181 0.0066828239855783 0.0 0.0 0.0 0.0 144 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1074047 CD34 SELP CD34-SELP Mast Cells Macrophages Mast Cells -> Macrophages 0.004806742354737 0.8532069650852002 0.941479368642921 0.8567148457705164 0.00083777361258 0.0021392900294222 0.0 0.0 0.0 0.0 165 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1074086 THBS2 CD36 THBS2-CD36 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0048056749664517 0.6242573126045354 0.6176321640000088 0.909150863993142 0.004981832968137 0.0007053434767499 0.0 5.301102629346904e-05 0.025612612555129 0.0 1572 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1074099 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0048052888410491 0.6332974881236617 0.941479368642921 0.6198216015396206 0.0015572459193676 0.0021392900294222 0.0 0.0 0.0 0.0 103 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1074111 VWF SELP VWF-SELP Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0048049098033623 0.9011206516381156 0.7760344326192508 0.6198216015396206 0.0008850282134344 0.0032078747392388 0.0 2.694401034649997e-05 0.0044710180154894 0.0 1687 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1074157 CD34 SELP CD34-SELP CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0048040128431553 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0298399317533219 0.0001189339410417 0.0 0.0 0.0 0.0 1490 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1074185 COL4A1 CD93 COL4A1-CD93 B Cells B Cells B Cells -> B Cells 0.0048031770818342 0.8684504425765611 0.7779918296243433 1.0 0.0016831757123532 0.001079730675535 0.0 0.0003022365504735 0.0465218294933517 0.0 1418 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1074220 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0048027456035946 0.6301823358791634 0.7830372268649692 0.6198216015396206 0.0015409900107563 0.0026038611777234 0.0 0.0041407867494824 0.3523709016759979 0.0 161 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1074288 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Luminal-like Amorphous DCIS Cells Myoepithelial Cells -> Luminal-like Amorphous DCIS Cells 0.004801167952564 0.724503440376099 0.2562573700401372 0.2461374514707439 0.0027791828709671 0.0096442330625583 0.0 3.575143005720229e-05 0.0363964038680263 0.0 12820 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1074328 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0048002776927269 0.9184503888425788 0.6571792026963191 0.6198216015396206 0.0004696576149175 0.0069630688870869 0.0 0.0 0.0 0.0 1422 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1074375 COL4A2 CD93 COL4A2-CD93 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0047991602589415 0.4630253981438691 0.7461459456652184 0.7204611100467462 0.0047240947268779 0.0010390313650636 0.0 0.0 0.0 0.0 43 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1074418 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.004798218491624 0.250044481781731 0.6587114738285964 0.2461374514707439 0.0070431301838115 0.0042738820064046 0.0 0.0 0.0 0.0 147 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1074424 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0047980680379329 0.250044481781731 0.6347970925105053 0.2461374514707439 0.0070431301838115 0.0044340558155446 0.0 0.0004468275245755 0.0582687452712779 0.0 373 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1074438 COL4A2 CD93 COL4A2-CD93 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0047978048864011 0.4630253981438691 0.4630027772793905 0.2461374514707439 0.0047240947268779 0.0048929293424311 0.0 0.0011070110701107 0.3579444139200703 0.0 271 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1074474 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0047971536272482 0.6301823358791634 0.6347970925105053 0.9592803095773328 0.000716220684292 0.0044340558155446 0.0 0.0004516711833785 0.0589003847864137 0.0 1476 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1074479 VWF LRP1 VWF-LRP1 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0047970496932077 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.00023686843287 0.0144359394371152 0.0 0.000263570094584 0.0232824110058306 0.0 1509 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1074656 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0047930279478377 0.7753420160918723 0.7346293219749174 0.7204611100467462 0.0009153913192522 0.0032275631628407 0.0 0.000219298245614 0.0087393582898308 0.0 285 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1074684 CCN1 CAV1 CCN1-CAV1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0047924358507901 0.7324582304061453 0.8617632615906476 0.7204611100467462 0.0025580826958339 0.0010414441948928 0.0 0.0 0.0 0.0 48 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1074732 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.004791250785309 0.2542249848376565 0.252518874138558 0.3990376746076917 0.0014656941948563 0.0322196586137726 0.0 0.0007490636704119 0.1310832576503466 0.0 89 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1074795 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0047899226248822 0.4604235282221027 0.7779918296243433 0.2461374514707439 0.0126864732057784 0.001079730675535 0.0 0.0 0.0 0.0 176 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1074812 CD48 CD2 CD48-CD2 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0047895926927104 0.6659645551150886 0.6614977577544194 0.9161861017439124 0.0081474500750471 0.0003671083100858 0.0 0.0010869565217391 1.0 0.0 460 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1074851 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0047885048641278 0.2490567623945399 0.8923034233058523 0.2461374514707439 0.011649387573427 0.00189193058407 0.0 0.0 0.0 0.0 222 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1074893 CCN1 CAV1 CCN1-CAV1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0047876535780508 0.8749036366850302 0.62431395375366 0.6198216015396206 0.0004337320404416 0.0082011408892332 0.0 0.0 0.0 0.0 10 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1074947 COL4A1 CD93 COL4A1-CD93 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0047866384839392 0.9102252263107924 0.4630027772793905 0.7204611100467462 0.0042860632265532 0.0009242223287825 0.0 0.0004382120946538 0.0845305766956597 0.0 326 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1074959 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Plasma Cells Myoepithelial Cells -> Plasma Cells 0.0047862084687808 0.724503440376099 0.7373999388878224 0.8293805866303694 0.0027791828709671 0.0009761781830445 0.0 0.0001902587519025 0.0733340367910464 0.0 219 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1074979 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0047858050119693 0.6342079770588467 0.7470475610360806 0.6198216015396206 0.0053032910137447 0.0007714919761827 0.0 0.0012919896640826 0.3747885192873723 0.0 129 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1075035 COL4A1 CD93 COL4A1-CD93 Mast Cells CAFs, DCIS Associated Mast Cells -> CAFs, DCIS Associated 0.0047842635917288 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.0002970267018348 0.0155837683010033 0.0 0.0002058460271716 0.0485040476780366 0.0 1041 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1075038 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0047842327769078 0.6160088550075702 0.4600037439857229 0.2461374514707439 0.0009692519480124 0.017738069381683 0.0 0.0005180005180005 0.1291427606903329 0.0 351 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1075054 MMRN2 CD93 MMRN2-CD93 Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0047840698951658 0.893316592628645 0.6587114738285964 0.6198216015396206 0.0007691101630988 0.0042738820064046 0.0 0.0001846381093057 0.0235696911274443 0.0 1354 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1075056 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0047839198851203 0.893316592628645 0.6347970925105053 0.6198216015396206 0.0007691101630988 0.0044340558155446 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1075153 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.004781880950883 0.6342079770588467 0.6571792026963191 1.0 0.000895875398841 0.0032020139126304 0.0 0.0 0.0 0.0 1846 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1075226 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0047802544678659 0.6332974881236617 0.950463483645931 0.6198216015396206 0.0016171311116606 0.0019776346124415 0.0 0.0003050640634533 0.1279883321860385 0.0 1490 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1075228 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0047802323419746 0.2486570577556728 0.9078204025796472 0.2461374514707439 0.0033537993821664 0.0064028969591119 0.0 0.0002709537572254 0.0282470193566746 0.0 1384 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1075279 VEGFC FLT1 VEGFC-FLT1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0047791313558122 0.7745997874735252 0.4630488285702799 0.6198216015396206 0.0012459853895406 0.0043013567716651 0.0 0.0005611672278338 0.0445067472626528 0.0 297 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1075294 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0047787328029388 0.7753420160918723 0.2550748532138862 0.2461374514707439 0.0009153913192522 0.0267255153180908 0.0 0.0003353454057679 0.0208616069505356 0.0 1491 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1075316 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0047782375483105 0.2451358214448441 0.8445107771175474 0.2461374514707439 0.0010709508378277 0.0218093597373452 0.0 0.0122767857142857 0.6653445044816192 0.0 64 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1075427 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0047753759055906 0.2534163760166434 0.8818326005152037 0.2461374514707439 0.0050543892975134 0.0042655619249233 0.0 0.0041666666666666 1.0 0.0 20 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1075480 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0047741228856296 0.6630837220165452 0.7461459456652184 0.6198216015396206 0.0037159398684439 0.0010390313650636 0.0 0.0 0.0 0.0 21 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1075640 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0047704189342459 0.6630837220165452 0.6587114738285964 1.0 0.0037159398684439 0.0007261054236978 0.0 0.0 0.0 0.0 1846 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1075700 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.004769068872633 0.9303167350027568 0.4623922682986163 0.7204611100467462 0.0016860250240652 0.0022515473538965 0.0 0.0 0.0 0.0 285 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1075790 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0047665689938416 0.250044481781731 0.4630027772793905 0.2461374514707439 0.0070431301838115 0.0058437228618857 0.0 0.0001683879658733 0.0340761655793587 0.0 13362 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1075831 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Macrophages 11q13 Invasive Tumor Cells (Mitotic) -> Macrophages 0.0047654243403798 0.6301823358791634 0.9195415044619336 0.6198216015396206 0.0024635726452692 0.0013235329769289 0.0 0.0 0.0 0.0 103 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1075835 THBS2 CD36 THBS2-CD36 Endothelial Cells Mast Cells Endothelial Cells -> Mast Cells 0.004765354005813 0.9197297916541942 0.8765901449012573 0.8567148457705164 0.0039472834455595 0.0004295051170816 0.0 0.0 0.0 0.0 225 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1075853 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0047648294588396 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.000716220684292 0.0058465532256424 0.0 0.0003679175864606 0.0774346065884502 0.0 453 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1075865 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0047645453634275 0.6301823358791634 0.7830372268649692 0.6198216015396206 0.00146889578236 0.0026038611777234 0.0 0.0 0.0 0.0 143 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1076031 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0047606940611437 0.6301823358791634 0.6587114738285964 0.9161861017439124 0.000716220684292 0.0042738820064046 0.0 0.0006127450980392 0.0782190239866656 0.0 408 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1076181 VWF LRP1 VWF-LRP1 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.0047574892247189 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0025256125075084 0.0016667952436519 0.0 0.0002307337332718 0.0286775290210749 0.0 394 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1076261 COL4A1 CD93 COL4A1-CD93 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0047554980919117 0.9102252263107924 0.6587114738285964 0.6198216015396206 0.0042860632265532 0.0007261054236978 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1076293 THBS2 CD36 THBS2-CD36 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0047548191306789 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.004981832968137 0.0007598956708367 0.0 0.0005980861244019 0.2813206099806884 0.0 209 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1076343 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0047535446686511 0.6332974881236617 0.6207977546603366 0.8693461273411047 0.0020251995753771 0.0016667952436519 0.0 8.417508417508418e-05 0.0104619874391699 0.0 270 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1076403 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0047522468793705 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0031934983073077 0.0011388334136451 0.0 0.0 0.0 0.0 81 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1076424 MMP2 PECAM1 MMP2-PECAM1 Mast Cells B Cells Mast Cells -> B Cells 0.0047518612065985 0.8560892486218385 0.6331674633943454 0.6198216015396206 0.0006966068981631 0.0049190726392343 0.0 0.0008928571428571 0.109063600876607 0.0 112 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1076485 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0047504918175922 0.7160288858520609 0.6571792026963191 0.6198216015396206 0.0012306151710811 0.0032020139126304 0.0 0.0 0.0 0.0 8 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1076496 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0047502853093422 0.6332974881236617 0.950463483645931 0.6198216015396206 0.0015572459193676 0.0019776346124415 0.0 0.0 0.0 0.0 339 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1076535 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0047495212008875 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0003521782369754 0.0104714078116759 0.0 0.0011528326745718 0.0967872743816542 0.0 69 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1076595 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0047483975467811 0.7487535481622718 0.7754239189773715 0.7827641335561659 0.0015847932820241 0.0015914585039484 0.0 0.0003450060376056 0.1674970176225473 0.0 527 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1076643 CD34 SELP CD34-SELP Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0047472115477487 0.8532069650852002 0.7478729882108823 0.7827641335561659 0.00083777361258 0.0027351735586246 0.0 0.0 0.0 0.0 23 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1076725 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0047454450994914 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.0047694898966413 0.0009242223287825 0.0 0.0 0.0 0.0 285 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1076756 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0047448676124989 0.6303682835571691 0.4614667734221426 0.2461374514707439 9.902323108165852e-05 0.1609352200462838 0.0 0.0 0.0 0.0 41 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1076760 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0047448078388031 0.8516956437178343 0.6571792026963191 0.6198216015396206 0.000472352586488 0.0069630688870869 0.0 0.0 0.0 0.0 144 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1076767 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.004744636872807 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0020251995753771 0.0018097844702233 0.0 0.0001758774329711 0.0182709201867861 0.0 1163 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1076823 COL4A2 CD93 COL4A2-CD93 Plasma Cells B Cells Plasma Cells -> B Cells 0.0047433036377813 0.4630253981438691 0.7779918296243433 0.6198216015396206 0.0047240947268779 0.001079730675535 0.0 0.0 0.0 0.0 315 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1076859 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0047426586834664 0.2451358214448441 0.663300745568453 0.2461374514707439 0.0010709508378277 0.0265498740402422 0.0 0.0 0.0 0.0 4 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1077116 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0047370468900392 0.2534163760166434 0.7746834992804791 0.2461374514707439 0.0050543892975134 0.0046263543438723 0.0 0.0 0.0 0.0 74 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1077126 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0047368533100593 0.7856500335676843 0.7779918296243433 0.6198216015396206 0.0005542667491398 0.0053794918117879 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1077147 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0047362809674245 0.8571898293845529 0.6347970925105053 0.6198216015396206 0.0004196880356983 0.0079745943515326 0.0 0.0 0.0 0.0 343 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1077172 VWF SELP VWF-SELP CAFs, DCIS Associated B Cells CAFs, DCIS Associated -> B Cells 0.0047357954502464 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0071496754272206 0.0004582650848664 0.0 2.14813541845678e-05 0.0108037516916263 0.0 4232 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1077175 VWF SELP VWF-SELP CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0047356644020177 0.6332974881236617 0.4623922682986163 0.2461374514707439 0.0016171311116606 0.0096770075292062 0.0 0.0 0.0 0.0 155 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1077182 A2M LRP1 A2M-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0047355104365388 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.0021905373114471 0.0028784826949613 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1077228 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0047343964427289 0.8937519114898692 0.7769451595923457 0.7827641335561659 0.0037268694422441 0.0005558995075445 0.0 0.0001584283903675 0.0299627736651054 0.0 526 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1077336 CD34 SELP CD34-SELP Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0047325131084582 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.0018206581062216 0.002113171886167 0.0 0.0 0.0 0.0 285 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1077381 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Luminal-like Amorphous DCIS Cells T Lymphocytes -> Luminal-like Amorphous DCIS Cells 0.0047316314112309 0.6301823358791634 0.4630027772793905 0.2461374514707439 0.0031934983073077 0.0048929293424311 0.0 0.0 0.0 0.0 383 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1077387 C3 LRP1 C3-LRP1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0047314313633813 0.7148920381722296 0.7769451595923457 0.7204611100467462 0.005043231651446 0.0005558995075445 0.0 0.0009803921568627 0.2197884656643749 0.0 51 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1077430 THBS2 CD36 THBS2-CD36 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0047307089704334 0.7809827257946271 0.7373999388878224 0.7204611100467462 0.0004779710276932 0.0056518532344078 0.0 0.0 0.0 0.0 85 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1077477 VWF LRP1 VWF-LRP1 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0047296765944004 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0019871862905238 0.0018097844702233 0.0 0.0 0.0 0.0 209 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1077482 CD48 CD2 CD48-CD2 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0047295874552999 0.4593282471594782 0.6614977577544194 0.6198216015396206 0.0161888123016941 0.0003671083100858 0.0 0.0 0.0 0.0 422 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1077559 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0047278597062121 0.6160088550075702 0.4596166826058663 0.2461374514707439 0.0021291294377375 0.0075270071967493 0.0 0.0001036591686534 0.0457587007009492 0.0 877 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1077561 JAG1 NOTCH2 JAG1-NOTCH2 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.004727849191584 0.8630183004227985 0.663300745568453 0.7917001487310438 0.0001109003117737 0.0222186841038061 0.0 0.0005411255411255 0.0213977298797115 0.0 968 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1077578 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0047274048622318 0.785133132759182 0.7167436199046466 0.7204611100467462 0.001039571291679 0.0026482500471321 0.0 0.0 0.0 0.0 85 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1077603 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0047269436200501 0.8667347161816407 0.7763428264267787 0.6198216015396206 0.0106228227237899 0.0002517784065132 0.0 0.0 0.0 0.0 1109 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1077629 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0047263097977843 0.4604235282221027 0.7461459456652184 0.2461374514707439 0.0126864732057784 0.0010390313650636 0.0 0.0 0.0 0.0 84 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1077827 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0047219079449726 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0137371823984124 0.0002517784065132 0.0 0.0 0.0 0.0 339 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1077848 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0047216209919755 0.4619393085577573 0.2491073778594529 0.2461374514707439 0.0051428381563772 0.0076066460958003 0.0 0.0 0.0 0.0 271 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1077986 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0047185150347486 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0014378253178126 0.0024251058581756 0.0 0.0 0.0 0.0 1422 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1078007 CD34 SELP CD34-SELP Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0047180092454725 0.8532069650852002 0.7760344326192508 0.6198216015396206 0.00083777361258 0.0032078747392388 0.0 0.0 0.0 0.0 162 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1078020 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0047176432839134 0.7766289238087107 0.8817184225858201 1.0 0.0047694898966413 0.0003375370073613 0.0 1.7772722425621154e-05 0.0154859561524495 0.0 4019 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1078160 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0047145726989041 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.0047694898966413 0.0007261054236978 0.0 0.0005239259517988 0.0700558914077936 0.0 409 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1078204 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0047134482069431 0.893316592628645 0.7830372268649692 0.7827641335561659 0.0007691101630988 0.0026038611777234 0.0 0.0 0.0 0.0 179 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1078354 C3 LRP1 C3-LRP1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0047099132364114 0.7796725988275006 0.7346293219749174 0.7204611100467462 0.000819605673545 0.0032275631628407 0.0 0.0 0.0 0.0 37 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1078426 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0047080503146642 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.141548283585814 0.0001990509171164 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1078430 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0047078601746716 0.7719609236370527 0.7763428264267787 0.8567148457705164 0.0014378253178126 0.0014748371602574 0.0 0.0 0.0 0.0 137 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1078518 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0047059747948779 0.6332974881236617 0.4623922682986163 0.2461374514707439 0.0015572459193676 0.0096770075292062 0.0 0.0 0.0 0.0 351 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1078520 CD48 CD2 CD48-CD2 Pericytes CXCL14+ Fibroblasts Pericytes -> CXCL14+ Fibroblasts 0.0047059565208457 0.7719609236370527 0.7763428264267787 0.9429656149619918 0.0076331962782219 0.0002517784065132 0.0 0.0 0.0 0.0 2966 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1078539 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0047056425861232 0.6242573126045354 0.7763054211764489 0.6198216015396206 0.0020491452254277 0.0017638974017382 0.0 0.0 0.0 0.0 129 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1078576 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0047045757548466 0.8571898293845529 0.7154802332407408 0.7204611100467462 0.0004196880356983 0.0058465532256424 0.0 0.0 0.0 0.0 66 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1078611 VWF ITGA9 VWF-ITGA9 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0047037703422455 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0003457348439318 0.0112932915661816 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1078684 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0047021498394128 0.6589792304505506 0.8755243548400705 0.6198216015396206 0.0072827533047186 0.0004150165744076 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1078729 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0047008835783073 0.8571898293845529 0.6347970925105053 0.6198216015396206 0.0004196880356983 0.0076236123034427 0.0 0.0 0.0 0.0 144 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1078741 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0047006486272861 0.8640667164982425 0.2491073778594529 0.2461374514707439 0.002676946692949 0.0076066460958003 0.0 4.191817572099262e-05 0.0174634320551667 0.0 1491 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1078755 A2M LRP1 A2M-LRP1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0047003297362025 0.7741139100414175 0.6207977546603366 0.7917001487310438 0.0015661096645571 0.0018097844702233 0.0 0.0 0.0 0.0 42 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1078795 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) CAFs, DCIS Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, DCIS Associated 0.0046994123236021 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0001971810371238 0.0310998965832685 0.0 0.0 0.0 0.0 77 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1078817 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0046990814801707 0.6301823358791634 0.6347970925105053 0.9592803095773328 0.0024635726452692 0.0011388334136451 0.0 0.0 0.0 0.0 1495 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1078858 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0046979982975709 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0014431743145616 0.0023576674662702 0.0 0.0001724137931034 0.0826729676540828 0.0 1305 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1078940 C3 LRP1 C3-LRP1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0046958659800823 0.7796725988275006 0.2550748532138862 0.2461374514707439 0.000819605673545 0.0267255153180908 0.0 0.0 0.0 0.0 122 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1078953 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0046954925755281 0.7160288858520609 0.8923034233058523 0.7204611100467462 0.0012306151710811 0.00189193058407 0.0 0.0004945598417408 0.2187916205066717 0.0 337 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1078984 VWF SELP VWF-SELP T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0046948720533729 0.6332974881236617 0.8347297932672282 0.6198216015396206 0.0036144684673052 0.0009042150166242 0.0 0.0 0.0 0.0 333 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1078985 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0046948701851327 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0033537993821664 0.0083442542366581 0.0 0.0010330578512396 0.0568676674596974 0.0 176 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1079005 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0046944433119545 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0014431743145616 0.0026482500471321 0.0 0.0002450980392156 0.2238489092690478 0.0 714 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1079107 CCN1 CAV1 CCN1-CAV1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0046923937978211 0.8749036366850302 0.943345641464811 0.8567148457705164 0.0004337320404416 0.0034806998160403 0.0 0.0002252252252252 0.083380112329852 0.0 148 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1079205 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0046903587453758 0.6303682835571691 0.773263018678637 0.7827641335561659 0.0003788349535045 0.0073658308476012 0.0 0.0001469723691945 0.0267599212355317 0.0 162 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1079260 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0046890203381723 0.6332974881236617 0.6207977546603366 0.9592803095773328 0.0015572459193676 0.0018097844702233 0.0 0.0002128306476132 0.0221097824214977 0.0 1495 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1079457 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0046847659749502 0.6160088550075702 0.6631822525600675 0.9592803095773328 0.0009692519480124 0.0027830389352876 0.0 0.0001824262693827 0.0567839337520773 0.0 1495 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1079492 THBS2 CD36 THBS2-CD36 Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0046840263625776 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0039472834455595 0.0007598956708367 0.0 0.0 0.0 0.0 312 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1079559 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0046825935867314 0.6332974881236617 0.6207977546603366 0.9161861017439124 0.0016171311116606 0.0018097844702233 0.0 0.0005434782608695 0.0564589086834673 0.0 460 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1079649 VEGFC FLT1 VEGFC-FLT1 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0046807915016321 0.8963332422588541 0.878254460598671 0.8875000050982297 0.0026007495851186 0.0005788283879716 0.0 0.0 0.0 0.0 1462 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1079743 C1QB LRP1 C1QB-LRP1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0046786597579305 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0012213774841743 0.0028784826949613 0.0 0.0 0.0 0.0 10 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1079796 CD48 CD2 CD48-CD2 Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0046774200678228 0.4593282471594782 0.7763428264267787 0.7204611100467462 0.0161888123016941 0.0002517784065132 0.0 0.0 0.0 0.0 1538 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1079813 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0046770860241159 0.7487535481622718 0.4596166826058663 0.2461374514707439 0.0016417770622885 0.0075270071967493 0.0 0.0011086474501108 0.4893948843260059 0.0 41 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1079891 C3 LRP1 C3-LRP1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0046752863795483 0.2485046029682279 0.9078204025796472 0.2461374514707439 0.0013028322726017 0.0144359394371152 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1079893 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Endothelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Endothelial Cells 0.0046752261244516 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0001971810371238 0.0178869147172998 0.0 0.0001734906315058 0.0296584731632907 0.0 262 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1079931 HSPG2 LRP1 HSPG2-LRP1 B Cells B Cells B Cells -> B Cells 0.004674327650485 0.7789175740361626 0.6207977546603366 1.0 0.0012941512528773 0.0016667952436519 0.0 0.000146920545369 0.0185876479116891 0.0 1418 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1079975 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0046733072141871 0.6561647292424944 0.8755243548400705 0.6198216015396206 0.0070489045197697 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1080020 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0046724599288366 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0003788349535045 0.0083242517891534 0.0 0.0001840942562592 0.0215364933343232 0.0 388 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1080053 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0046717130544116 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0024635726452692 0.0109188419829382 0.0 0.0009496676163342 0.1367076965444908 0.0 351 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1080105 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.004670350707881 0.6342079770588467 0.7754072541855492 0.909150863993142 0.0002327631000826 0.009971631136135 0.0 0.0 0.0 0.0 1549 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1080134 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0046697159295103 0.8937519114898692 0.8755243548400705 0.8567148457705164 0.0037268694422441 0.0004150165744076 0.0 0.0 0.0 0.0 137 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1080150 VWF LRP1 VWF-LRP1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0046693527743747 0.7158082793127664 0.9078204025796472 0.7204611100467462 0.0003457348439318 0.0064028969591119 0.0 0.0001485442661913 0.0154857891818727 0.0 306 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1080261 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0046663943124246 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.0024635726452692 0.001079730675535 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1080313 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0046652935040699 0.785133132759182 0.6331674633943454 0.6198216015396206 0.001039571291679 0.0032187363284526 0.0 0.00015625 0.0454588475993942 0.0 160 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1080335 COL4A1 CD93 COL4A1-CD93 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0046648766910494 0.9102252263107924 0.8817184225858201 0.8875000050982297 0.0042860632265532 0.0003375370073613 0.0 0.0 0.0 0.0 1462 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1080489 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Pericytes Myeloid Cells -> Pericytes 0.0046612354019267 0.6303682835571691 0.773263018678637 0.7827641335561659 0.0003788349535045 0.0070956399217802 0.0 0.0001836210062431 0.0230450869051749 0.0 389 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1080534 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0046599783443872 0.6582846571368821 0.8817184225858201 0.6198216015396206 0.0084325366891025 0.0003375370073613 0.0 0.0 0.0 0.0 380 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1080616 VWF ITGA9 VWF-ITGA9 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0046579663226794 0.7848266128497919 0.6252253442669611 0.6198216015396206 0.0004024409845247 0.0083442542366581 0.0 0.0 0.0 0.0 144 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1080769 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0046540885320434 0.6213271600240247 0.252518874138558 0.2461374514707439 0.013905026986541 0.0018925243453249 0.0 0.0003875968992248 0.0214705086298432 0.0 86 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1080819 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells 0.0046530947169044 0.2510234128936706 0.6176321640000088 0.2461374514707439 0.0009262556366009 0.02871400543887 0.0 0.0 0.0 0.0 186 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1080835 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0046525676250182 0.9303167350027568 0.8347297932672282 0.8567148457705164 0.0016860250240652 0.0009042150166242 0.0 0.0 0.0 0.0 137 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1080845 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0046523974606331 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0001971810371238 0.0292791515533623 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1080917 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0046506378736062 0.6160088550075702 0.4596166826058663 0.6198216015396206 0.0001971810371238 0.0292373734098458 0.0 0.0009030704394942 0.1379040023733667 0.0 453 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1080972 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.004649630555561 0.7487535481622718 0.4596166826058663 0.2461374514707439 0.0015847932820241 0.0075270071967493 0.0 0.0003725782414307 0.1644687726013626 0.0 122 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1080986 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0046491961256072 0.2490567623945399 0.6580560501976399 0.2461374514707439 0.000126812416921 0.1973932010691654 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1081033 C3 LRP1 C3-LRP1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0046482158865119 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0013028322726017 0.0203874717835032 0.0 0.0004020467836257 0.0514263806405283 0.0 684 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1081091 C1QB LRP1 C1QB-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.004647000676427 0.7452691992612583 0.6207977546603366 0.6198216015396206 0.0012199377895337 0.0028784826949613 0.0 0.0 0.0 0.0 30 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1081182 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0046447634434816 0.2510234128936706 0.6176321640000088 0.2461374514707439 0.0009262556366009 0.0284069116891947 0.0 0.0 0.0 0.0 727 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1081201 COL4A2 CD93 COL4A2-CD93 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0046442629270919 0.8355319038299565 0.6587114738285964 0.6198216015396206 0.001123788079051 0.0026174949623928 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1081210 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0046440744288688 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0021291294377375 0.0015914585039484 0.0 8.197393228953193e-05 0.0397975330419668 0.0 1109 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1081288 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0046424373488097 0.7487535481622718 0.7757991160529997 0.8567148457705164 0.0016417770622885 0.0012252690191386 0.0 0.0006142506142506 0.4928574292215195 0.0 148 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1081331 COL4A2 CD93 COL4A2-CD93 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0046412412116586 0.7482742921073442 0.8817184225858201 0.7827641335561659 0.005733874009046 0.0003375370073613 0.0 0.0 0.0 0.0 527 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1081399 VWF LRP1 VWF-LRP1 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0046394068980778 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0003457348439318 0.0104714078116759 0.0 7.54557527465894e-05 0.0063349667352818 0.0 753 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1081456 MMP2 PECAM1 MMP2-PECAM1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0046382301704481 0.6303642896310324 0.7841656220878274 0.6198216015396206 0.0024819960935566 0.001309307002134 0.0 0.0010948905109489 0.1309546875242629 0.0 137 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1081460 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0046381070620979 0.4629984640915818 0.2550748532138862 0.2461374514707439 0.0012814156885439 0.0267255153180908 0.0 5.125051250512505e-05 0.0030636208562312 0.0 271 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1081485 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0046375487356167 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.000245041593909 0.0112932915661816 0.0 0.0 0.0 0.0 390 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1081513 CD34 SELP CD34-SELP B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0046370456266303 0.633566764858408 0.7760344326192508 0.8693461273411047 0.0006336851232098 0.0036702914086929 0.0 0.0 0.0 0.0 360 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1081567 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0046359260682895 0.255669001367946 0.6632137581773894 0.2461374514707439 0.0061207051981986 0.0038860320327025 0.0 0.0 0.0 0.0 26 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1081608 COL4A1 CD93 COL4A1-CD93 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0046349261424474 0.7463064942968751 0.6587114738285964 0.6198216015396206 0.0012430446376512 0.0026174949623928 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1081636 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0046344687259376 0.4629984640915818 0.7769451595923457 0.2461374514707439 0.0201301851612071 0.0005558995075445 0.0 0.0003306878306878 0.0488721389063081 0.0 84 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1081640 VWF ITGA9 VWF-ITGA9 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0046343772349532 0.7158082793127664 0.2531744428854943 0.2461374514707439 0.0003457348439318 0.0642389143033604 0.0 0.0 0.0 0.0 271 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1081651 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0046341192378334 0.7856500335676843 0.6347970925105053 0.6198216015396206 0.0005542667491398 0.0057802287131517 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1081756 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Macrophages Macrophages -> Macrophages 0.004631853657735 0.6303682835571691 0.773263018678637 1.0 0.0002750231449378 0.0073658308476012 0.0 0.0002421635863458 0.0440918148917427 0.0 2458 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1081778 MMRN2 CD93 MMRN2-CD93 Plasma Cells CAFs, DCIS Associated Plasma Cells -> CAFs, DCIS Associated 0.0046315016336044 0.7205550478301406 0.4630027772793905 0.8767341187813953 0.0002165306714062 0.0155837683010033 0.0 0.0 0.0 0.0 2450 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1081790 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0046311241530517 0.255669001367946 0.6631822525600675 0.2461374514707439 0.0061207051981986 0.0038621268649178 0.0 0.0003655861564708 0.2259755182686933 0.0 373 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1081807 COL4A2 CD93 COL4A2-CD93 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0046306123497551 0.7783550150988336 0.6587114738285964 0.7917001487310438 0.0033449520260795 0.0007261054236978 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1081904 VWF SELP VWF-SELP Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0046284228067808 0.7158082793127664 0.8347297932672282 0.7204611100467462 0.0025256125075084 0.0009042150166242 0.0 0.0 0.0 0.0 38 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1081929 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0046280029343914 0.4636527906642655 0.8331580262014722 0.7204611100467462 0.0023125636768155 0.001526625481682 0.0 0.0 0.0 0.0 48 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1082007 THBS2 CD36 THBS2-CD36 Endothelial Cells B Cells Endothelial Cells -> B Cells 0.0046262296211721 0.9197297916541942 0.6176321640000088 0.6198216015396206 0.0039472834455595 0.0007053434767499 0.0 2.938410907381288e-05 0.0141971181017852 0.0 1418 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1082037 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0046254702906735 0.6303642896310324 0.6331674633943454 0.9161861017439124 0.0008320501336843 0.0032187363284526 0.0 0.0003063725490196 0.0891349952929299 0.0 408 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1082066 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0046247686125259 0.6249837837987587 0.8341464445360613 0.6198216015396206 0.0161757332769496 0.0001871866311057 0.0 0.0 0.0 0.0 151 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1082278 MMP2 PECAM1 MMP2-PECAM1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0046201415614498 0.8560892486218385 0.6331674633943454 0.6198216015396206 0.0006966068981631 0.0041555861088636 0.0 0.0 0.0 0.0 10 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1082308 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0046194902829688 0.6301823358791634 0.8347945881127203 0.6198216015396206 0.0024635726452692 0.0012097093680331 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1082363 VWF ITGA9 VWF-ITGA9 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0046177866557116 0.7158082793127664 0.7292496872084557 1.0 0.0003457348439318 0.0053724660607752 0.0 0.0 0.0 0.0 283 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1082451 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0046157570045017 0.6301823358791634 0.7461459456652184 0.6198216015396206 0.0031934983073077 0.0010390313650636 0.0 0.0 0.0 0.0 361 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1082614 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Plasma Cells 11q13 Invasive Tumor Cells -> Plasma Cells 0.0046121867189635 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0034559943126159 0.0009761781830445 0.0 0.0 0.0 0.0 103 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1082776 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0046087115789973 0.9184503888425788 0.7746834992804791 0.6198216015396206 0.0004696576149175 0.0046263543438723 0.0 8.86053517632465e-05 0.048301447234543 0.0 1881 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1082810 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0046081318564956 0.6303682835571691 0.663300745568453 0.6198216015396206 9.902323108165852e-05 0.0373075519081129 0.0 0.0023809523809523 0.0449259252993362 0.0 10 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1082882 VWF SELP VWF-SELP B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0046064703099453 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.00023686843287 0.0222228052993653 0.0 5.560869275085081e-05 0.0092082137130428 0.0 4087 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1082916 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0046058951627348 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0049987108499989 0.0049190726392343 0.0 0.0002840909090909 0.0347020548243749 0.0 176 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1082922 VEGFC FLT1 VEGFC-FLT1 B Cells B Cells B Cells -> B Cells 0.0046057802390164 0.7745997874735252 0.777821334064334 1.0 0.0012459853895406 0.001271575589586 0.0 0.0001175364362952 0.028784602854255 0.0 1418 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1082930 CD34 SELP CD34-SELP B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0046054100651725 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0006336851232098 0.0045674276780054 0.0 0.0 0.0 0.0 50 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1082968 CCN1 CAV1 CCN1-CAV1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0046045917017793 0.7797135509308979 0.62431395375366 0.6198216015396206 0.0009209869688402 0.0034299077593249 0.0 0.0 0.0 0.0 32 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1082994 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0046039562460223 0.2451358214448441 0.663300745568453 0.2461374514707439 0.0010709508378277 0.0222186841038061 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1083111 COL4A2 CD93 COL4A2-CD93 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0046006507526433 0.8355319038299565 0.8347945881127203 1.0 0.001123788079051 0.0012097093680331 0.0 0.0 0.0 0.0 14 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1083129 CCN1 CAV1 CCN1-CAV1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0046002245009864 0.6213271600240247 0.7832252605020791 0.6198216015396206 0.0023088899408624 0.00136079311934 0.0 0.0 0.0 0.0 137 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1083238 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0045975876731523 0.8718210606749883 0.777821334064334 0.6198216015396206 0.0017670878089588 0.001271575589586 0.0 0.0 0.0 0.0 791 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1083253 C3 LRP1 C3-LRP1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0045971021697269 0.7148920381722296 0.8755243548400705 0.7204611100467462 0.005043231651446 0.0004150165744076 0.0 0.0 0.0 0.0 38 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1083283 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0045962704168136 0.743507317541692 0.777821334064334 0.6198216015396206 0.0020684923107111 0.001271575589586 0.0 0.0 0.0 0.0 144 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1083332 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Mast Cells Macrophages -> Mast Cells 0.0045951169381167 0.8771078809726828 0.8341464445360613 0.8567148457705164 0.0080232294691882 0.0001871866311057 0.0 0.0 0.0 0.0 165 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1083365 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Dendritic Cells B Cells -> Dendritic Cells 0.004594285936713 0.6342079770588467 0.7746834992804791 0.909150863993142 0.0002327631000826 0.0090444648829713 0.0 0.0001075962986873 0.0122198085878199 0.0 1549 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1083429 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0045925224247811 0.8630183004227985 0.8445107771175474 0.909150863993142 0.0016575843792215 0.0008542071298387 0.0 9.087604507451837e-05 0.0167843020999995 0.0 1572 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1083513 COL4A2 CD93 COL4A2-CD93 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0045907275342486 0.4630253981438691 0.4630027772793905 1.0 0.0047240947268779 0.0009242223287825 0.0 0.0003533568904593 0.0673854375496627 0.0 283 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1083577 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0045892907987067 0.8284725546778968 0.6331674633943454 0.6198216015396206 0.0012187708721425 0.0023576674662702 0.0 0.0 0.0 0.0 30 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1083585 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0045891334505107 0.9219165193585238 0.252518874138558 0.2461374514707439 0.0086134406931133 0.0018925243453249 0.0 0.0080459770114942 0.4456981446608839 0.0 29 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1083624 MMRN2 CD93 MMRN2-CD93 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0045884530714341 0.8571898293845529 0.7779918296243433 0.6198216015396206 0.0004196880356983 0.0053794918117879 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1083656 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0045877521739757 0.6319926036888139 0.9078204025796472 0.6198216015396206 0.0004094805141934 0.0064028969591119 0.0 0.0 0.0 0.0 380 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1083658 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Endothelial Cells T Lymphocytes -> Endothelial Cells 0.0045877213421199 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0006856224272495 0.0032875740549697 0.0 7.490412272291466e-05 0.0120861535455427 0.0 4768 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1083702 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0045867044866392 0.2451358214448441 0.4614667734221426 0.2461374514707439 0.0010709508378277 0.0312252462757311 0.0 0.004700919855669 0.2560305883538948 0.0 937 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1083743 C3 LRP1 C3-LRP1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.00458555134287 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0691889863216023 0.0003386430177035 0.0 0.0116666666666666 1.0 0.0 75 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1083765 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0045849303277311 0.8516956437178343 0.836885603004631 1.0 0.000472352586488 0.0027591088867233 0.0 0.0714285714285714 1.0 0.0 14 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1083944 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0045805078543281 0.2491449441646273 0.6572093097629401 0.2461374514707439 0.0108445362943651 0.002113171886167 0.0 0.0 0.0 0.0 147 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1083949 THBS2 CD36 THBS2-CD36 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0045803795413789 0.6242573126045354 0.8765901449012573 0.6198216015396206 0.0063387366560491 0.0004295051170816 0.0 0.0006256256256256 0.075771596289366 0.0 333 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1083992 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0045795292761285 0.255669001367946 0.7447682696221608 0.2461374514707439 0.0061207051981986 0.0032154705418133 0.0 0.0016233766233766 0.1377990104144806 0.0 84 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1084030 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0045785503742575 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.0003521782369754 0.0083442542366581 0.0 0.0 0.0 0.0 38 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1084123 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0045765435533836 0.6342079770588467 0.7746834992804791 0.909150863993142 0.0028649117803088 0.00071798405859 0.0 0.0001060220525869 0.0560245694542981 0.0 1572 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1084201 MMRN2 CLEC14A MMRN2-CLEC14A B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0045748928960914 0.6301823358791634 0.6347970925105053 0.9318789094584046 0.0003083910058032 0.0079745943515326 0.0 0.0001337345369441 0.0160244639221977 0.0 4985 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1084207 C3 LRP1 C3-LRP1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0045746669714497 0.8509500867818902 0.7346293219749174 0.7204611100467462 0.0006305085967044 0.0032275631628407 0.0 0.0 0.0 0.0 50 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1084229 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0045740914263942 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.000245041593909 0.0104714078116759 0.0 0.0 0.0 0.0 1881 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1084237 DLL1 NOTCH3 DLL1-NOTCH3 B Cells B Cells B Cells -> B Cells 0.004573918719866 0.6249837837987587 0.7746834992804791 1.0 0.00263399584678 0.00071798405859 0.0 0.0001175364362952 0.0889758875344782 0.0 1418 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1084260 COL4A1 CD93 COL4A1-CD93 B Cells Mast Cells B Cells -> Mast Cells 0.0045733525002981 0.8684504425765611 0.8347945881127203 0.6198216015396206 0.0016831757123532 0.0012097093680331 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1084392 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0045698550906274 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0053032910137447 0.0004874986369898 0.0 0.0 0.0 0.0 1109 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1084427 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0045691325729284 0.9275752708651288 0.2531744428854943 0.2461374514707439 0.000245041593909 0.0642389143033604 0.0 0.0001829156758734 0.008561159234453 0.0 1491 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1084484 VWF LRP1 VWF-LRP1 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0045681610057175 0.6332974881236617 0.6207977546603366 0.9318789094584046 0.00023686843287 0.0104714078116759 0.0 6.838697911917569e-05 0.0057415004433306 0.0 4985 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1084489 CD34 SELP CD34-SELP B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0045680909844619 0.633566764858408 0.7760344326192508 0.909150863993142 0.0006336851232098 0.0032078747392388 0.0 0.0 0.0 0.0 1549 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1084637 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0045640194740794 0.7451589345683471 0.930308383061206 0.7827641335561659 0.0040724665904272 0.0004089864655001 0.0 0.0001185958254269 0.1524322734924948 0.0 527 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1084744 THBS2 CD36 THBS2-CD36 Myeloid Cells T Lymphocytes Myeloid Cells -> T Lymphocytes 0.0045611872649229 0.7809827257946271 0.6176321640000088 0.6198216015396206 0.0004779710276932 0.0063011237754475 0.0 0.0002147766323024 0.0433386197880003 0.0 388 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1084755 C3 LRP1 C3-LRP1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0045610230853858 0.8509500867818902 0.2550748532138862 0.2461374514707439 0.0006305085967044 0.0267255153180908 0.0 0.0 0.0 0.0 41 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1084840 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0045591434554503 0.250044481781731 0.6347970925105053 0.2461374514707439 0.0070431301838115 0.003263637675389 0.0 0.0009170105456212 0.0924102625090918 0.0 727 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1084886 HSPG2 LRP1 HSPG2-LRP1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0045579547124182 0.7789175740361626 0.6207977546603366 0.7917001487310438 0.0012941512528773 0.0018097844702233 0.0 0.0003306878306878 0.0294200747338774 0.0 42 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1084967 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0045560177115715 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0053032910137447 0.0009249287638231 0.0 0.0 0.0 0.0 79 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1084983 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0045554553770798 0.8516956437178343 0.7746834992804791 0.6198216015396206 0.000472352586488 0.0046263543438723 0.0 0.0 0.0 0.0 343 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1084988 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0045553271459274 0.6242573126045354 0.6176321640000088 0.8824495942126559 0.0034559943126159 0.0007598956708367 0.0 2.7731558513588465e-05 0.0130440393756991 0.0 12020 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1085000 VWF LRP1 VWF-LRP1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0045551360740092 0.8525936146535493 0.9078204025796472 0.8567148457705164 0.0002103933337194 0.0064028969591119 0.0 0.0004606879606879 0.0480268732059432 0.0 148 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1085015 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0045547346339007 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0003521782369754 0.0642389143033604 0.0 0.0 0.0 0.0 19 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1085027 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0045543340673578 0.2486570577556728 0.7831795333113832 0.2461374514707439 0.0033537993821664 0.0055509879377996 0.0 0.0 0.0 0.0 84 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1085051 VWF ITGA9 VWF-ITGA9 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0045536327586497 0.7848266128497919 0.7292496872084557 0.7204611100467462 0.0004024409845247 0.0053724660607752 0.0 0.0024570024570024 0.2373182172267593 0.0 37 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1085158 MMRN2 CD93 MMRN2-CD93 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0045506832278271 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0002165306714062 0.0118035014556376 0.0 0.0 0.0 0.0 753 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1085164 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0045505052420501 0.7856500335676843 0.7830372268649692 1.0 0.0005542667491398 0.0026038611777234 0.0 0.0008833922261484 0.0751745342356479 0.0 1132 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1085199 CD48 CD2 CD48-CD2 Pericytes 11q13 Invasive Tumor Cells (G1/S) Pericytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0045497120465519 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0076331962782219 0.0003671083100858 0.0 0.0 0.0 0.0 377 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1085225 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0045491157031587 0.6160088550075702 0.7447682696221608 0.6198216015396206 0.0009692519480124 0.0032154705418133 0.0 0.0 0.0 0.0 23 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1085266 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0045481004991217 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0031934983073077 0.0007880862995141 0.0 8.865248226950354e-05 0.0591983505732712 0.0 1880 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1085306 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0045470236025851 0.250044481781731 0.7830372268649692 0.2461374514707439 0.0070431301838115 0.0026038611777234 0.0 0.0019841269841269 0.1688443903864157 0.0 84 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1085322 VWF LRP1 VWF-LRP1 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0045466112990352 0.9011206516381156 0.6207977546603366 0.6198216015396206 0.0008850282134344 0.0028784826949613 0.0 0.0 0.0 0.0 129 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1085337 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0045462667199204 0.7487535481622718 0.7757991160529997 0.7827641335561659 0.0015847932820241 0.0012252690191386 0.0 8.625150940141452e-05 0.0692057870254126 0.0 527 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1085356 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Dendritic Cells Macrophages -> Dendritic Cells 0.0045456998240152 0.893316592628645 0.6347970925105053 0.6198216015396206 0.0007691101630988 0.003263637675389 0.0 0.0001975894092076 0.0199117548441344 0.0 1687 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1085384 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0045449453118485 0.7451589345683471 0.6331674633943454 0.6198216015396206 0.0040724665904272 0.0007400708115376 0.0 0.00390625 0.7624633431085046 0.0 32 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1085401 THBS2 CD36 THBS2-CD36 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0045444574099222 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0009736808737186 0.0032616151102094 0.0 0.0 0.0 0.0 285 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1085408 C3 LRP1 C3-LRP1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0045443560765234 0.2485046029682279 0.2550748532138862 0.3990376746076917 0.0013028322726017 0.0267255153180908 0.0 0.0002808988764044 0.0444734482029904 0.0 89 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1085433 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0045438346694541 0.8640667164982425 0.930308383061206 1.0 0.002676946692949 0.0004089864655001 0.0 0.0 0.0 0.0 4019 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1085496 VWF SELP VWF-SELP Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0045423346949564 0.9011206516381156 0.4623922682986163 0.2461374514707439 0.0008850282134344 0.0096770075292062 0.0 0.0003456619426201 0.0986106864871013 0.0 263 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1085521 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0045417356333186 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0016575843792215 0.0021449819680126 0.0 0.0005977286312014 0.02169273539075 0.0 239 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1085541 CD34 SELP CD34-SELP Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0045414720136025 0.633566764858408 0.7760344326192508 0.909150863993142 0.0042829523358709 0.0004582650848664 0.0 0.0 0.0 0.0 1572 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1085551 THBS2 CD36 THBS2-CD36 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0045410634215958 0.6242573126045354 0.6176321640000088 0.8693461273411047 0.0008527942416386 0.0030676679668133 0.0 0.0 0.0 0.0 360 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1085554 C1QB LRP1 C1QB-LRP1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0045410001892274 0.8703788833238396 0.7769451595923457 0.6198216015396206 0.0037630364713574 0.0005558995075445 0.0 0.0 0.0 0.0 137 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1085563 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0045405489620453 0.7840818683779507 0.7746834992804791 0.6198216015396206 0.0032417203409647 0.00071798405859 0.0 0.0 0.0 0.0 144 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1085670 THBS2 CD36 THBS2-CD36 Macrophages Mast Cells Macrophages -> Mast Cells 0.0045380276047055 0.8858959974474152 0.8765901449012573 0.8567148457705164 0.0030563796158022 0.0004295051170816 0.0 0.0005050505050505 0.0611683431863245 0.0 165 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1085762 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0045357582655744 0.8721681415062816 0.885766439573873 1.0 0.0008193633790489 0.0013756087909864 0.0 0.0 0.0 0.0 4019 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1085817 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0045344350249168 0.7840818683779507 0.896164124004365 0.7827641335561659 0.0032417203409647 0.0004874986369898 0.0 0.0 0.0 0.0 527 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1085821 MMRN2 CD93 MMRN2-CD93 B Cells CAFs, DCIS Associated B Cells -> CAFs, DCIS Associated 0.0045343758616205 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0003083910058032 0.0155837683010033 0.0 6.116956202593589e-05 0.0083188642923116 0.0 4087 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1085901 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0045322120545783 0.4601010570874773 0.7769451595923457 0.2461374514707439 0.0177188549930425 0.0005558995075445 0.0 0.0 0.0 0.0 84 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1085942 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0045313480413994 0.6301823358791634 0.4630027772793905 0.2461374514707439 0.0024635726452692 0.0048929293424311 0.0 0.0 0.0 0.0 351 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1086039 C1QB LRP1 C1QB-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0045294026527378 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0026949121497638 0.0018097844702233 0.0 0.0 0.0 0.0 8 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1086116 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0045277316985319 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0001971810371238 0.0147571931436988 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1086135 HSPG2 LRP1 HSPG2-LRP1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0045271247185379 0.8349903778527206 0.6207977546603366 0.6198216015396206 0.0014804857410621 0.0018097844702233 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1086261 THBS2 CD36 THBS2-CD36 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0045236714460434 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0009736808737186 0.0031731220372828 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1086345 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0045218642262728 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0001109003117737 0.0312252462757311 0.0 0.0009120583717357 0.0496742868838752 0.0 496 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1086391 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0045205687342464 0.7468485855611411 0.7346293219749174 0.7204611100467462 0.0006689050756654 0.0032275631628407 0.0 0.0003753753753753 0.0206398752714172 0.0 37 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1086393 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0045205005110751 0.9184503888425788 0.836885603004631 0.8567148457705164 0.0004696576149175 0.0027591088867233 0.0 0.0 0.0 0.0 137 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1086516 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0045172992438044 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0048313935743179 0.0009242223287825 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1086542 THBS2 CD36 THBS2-CD36 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0045167176955623 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0008527942416386 0.0032616151102094 0.0 8.608815426997244e-05 0.0272639173219355 0.0 968 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1086545 COL4A1 CD93 COL4A1-CD93 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0045166251560699 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.0017253404164066 0.0026174949623928 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1086549 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0045165489159532 0.7856500335676843 0.4630027772793905 0.7204611100467462 0.0005542667491398 0.0058437228618857 0.0 0.0 0.0 0.0 85 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1086722 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Pericytes Macrophages -> Pericytes 0.0045124374882472 0.6303682835571691 0.773263018678637 0.8875000050982297 0.0002750231449378 0.0070956399217802 0.0 7.699118450937368e-05 0.0096626664576804 0.0 2474 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1086726 VEGFC FLT1 VEGFC-FLT1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0045123192615951 0.8317042416754105 0.6593689120110077 0.6198216015396206 0.0005440770361181 0.0045642085393754 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1086797 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0045105914061885 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0031934983073077 0.0009436211854823 0.0 0.0 0.0 0.0 713 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1086879 A2M LRP1 A2M-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.004508481843899 0.7460047258226694 0.6207977546603366 0.6198216015396206 0.0010163752993685 0.0028784826949613 0.0 0.0 0.0 0.0 30 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1086910 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.004507972525939 0.7451589345683471 0.8537710813834968 0.7827641335561659 0.0040724665904272 0.0004138063814779 0.0 0.0 0.0 0.0 23 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1086920 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0045077370128985 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0016171311116606 0.0016667952436519 0.0 3.7176563894121147e-05 0.0046206160445625 0.0 917 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1086940 VWF ITGA9 VWF-ITGA9 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.004507391230046 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.00023686843287 0.0112932915661816 0.0 0.0 0.0 0.0 50 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1086952 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.004507086195487 0.7468485855611411 0.2550748532138862 0.2461374514707439 0.0006689050756654 0.0267255153180908 0.0 0.000455373406193 0.0272210246570051 0.0 122 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1086962 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0045068772565258 0.785133132759182 0.7841656220878274 1.0 0.001039571291679 0.001309307002134 0.0 0.0007508833922261 0.0898096193298022 0.0 1132 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1087035 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Macrophages Macrophages -> Macrophages 0.0045052424336734 0.893316592628645 0.9195415044619336 1.0 0.0007691101630988 0.0013235329769289 0.0 6.780580417683754e-05 0.0182880302096389 0.0 2458 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1087069 VWF ITGA9 VWF-ITGA9 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0045046827237711 0.2486570577556728 0.9404022517663844 0.2461374514707439 0.0001077515101466 0.1347191569099048 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1087141 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0045028923806079 0.4629984640915818 0.8755243548400705 0.2461374514707439 0.0201301851612071 0.0004150165744076 0.0 0.0 0.0 0.0 34 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1087254 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.004500067791459 0.7719609236370527 0.7464347811605867 0.7827641335561659 0.0014378253178126 0.0012805120781881 0.0 0.0 0.0 0.0 526 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1087309 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0044986448844772 0.2542249848376565 0.7283139964676212 0.2461374514707439 0.0014656941948563 0.0124087765732037 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1087314 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0044986072427285 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0616816618657801 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1087323 THBS2 CD36 THBS2-CD36 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0044982610811232 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0009736808737186 0.0030676679668133 0.0 0.0 0.0 0.0 126 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1087349 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0044975190106678 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0020251995753771 0.0022515473538965 0.0 0.0 0.0 0.0 79 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1087404 THBS2 CD36 THBS2-CD36 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.004496058610791 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0008527942416386 0.0031731220372828 0.0 0.0 0.0 0.0 50 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1087442 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0044953235622454 0.2490567623945399 0.6571792026963191 0.2461374514707439 0.000126812416921 0.1615138601457002 0.0 0.0 0.0 0.0 184 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1087614 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0044908135021895 0.6319926036888139 0.6207977546603366 1.0 0.0007263013575398 0.0028784826949613 0.0 0.0001288659793814 0.0333414141966925 0.0 1552 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1087673 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0044889375411041 0.8571898293845529 0.6347970925105053 0.6198216015396206 0.0004196880356983 0.0057802287131517 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1087752 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0044867889475522 0.7789175740361626 0.2550748532138862 0.2461374514707439 0.0492631209980634 0.0003386430177035 0.0 0.0005603586295228 0.079868752474289 0.0 694 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1087765 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0044865035122892 0.8560892486218385 0.7167436199046466 0.7204611100467462 0.0006966068981631 0.0026482500471321 0.0 0.0 0.0 0.0 66 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1087769 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0044863710968538 0.718867305289982 0.2491073778594529 0.2461374514707439 0.0024319941937022 0.0076066460958003 0.0 0.0 0.0 0.0 271 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1087778 COL4A1 CD93 COL4A1-CD93 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0044860905912625 0.8684504425765611 0.4630027772793905 0.2461374514707439 0.0016831757123532 0.0048929293424311 0.0 0.0 0.0 0.0 211 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1087854 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0044843334565747 0.6342079770588467 0.836885603004631 0.6198216015396206 0.000895875398841 0.0027591088867233 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1087893 VWF SELP VWF-SELP Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0044833379177112 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0019871862905238 0.0022515473538965 0.0 0.0 0.0 0.0 239 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1087910 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0044827847174983 0.8284725546778968 0.7841656220878274 0.7827641335561659 0.0012187708721425 0.001309307002134 0.0 0.0 0.0 0.0 23 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1088044 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0044794763656817 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0015572459193676 0.0016667952436519 0.0 0.0 0.0 0.0 42 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1088100 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0044782216364994 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0049987108499989 0.0041555861088636 0.0 0.0002010723860589 0.0382034338410995 0.0 373 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1088186 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0044760466878484 0.2486570577556728 0.7292496872084557 0.2461374514707439 0.0033537993821664 0.0053724660607752 0.0 0.0006684491978609 0.0645645149808095 0.0 272 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1088211 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0044754606682136 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.0003521782369754 0.0064028969591119 0.0 2.990430622009569e-05 0.0031175338747717 0.0 380 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1088253 THBS2 CD36 THBS2-CD36 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0044744027280644 0.2510234128936706 0.8587566561291643 0.2461374514707439 5.260070730345377e-05 0.287457858136305 0.0 0.0 0.0 0.0 9 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1088338 VWF ITGA9 VWF-ITGA9 Plasma Cells B Cells Plasma Cells -> B Cells 0.0044723999096072 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0003457348439318 0.0083442542366581 0.0 0.0 0.0 0.0 315 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1088355 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0044720168278341 0.633566764858408 0.6572093097629401 1.0 0.0018436902762588 0.0010419094417808 0.0 0.0002708559046587 0.0208981866469295 0.0 1846 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1088393 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0044711226025394 0.6301823358791634 0.6347970925105053 0.9318789094584046 0.0031934983073077 0.000671064546954 0.0 0.0 0.0 0.0 5010 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1088422 CCN1 CAV1 CCN1-CAV1 B Cells Mast Cells B Cells -> Mast Cells 0.0044703005322965 0.6213271600240247 0.8617632615906476 0.6198216015396206 0.0023088899408624 0.0010414441948928 0.0 0.0003436426116838 0.0434285867001623 0.0 97 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1088521 C1QB LRP1 C1QB-LRP1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0044676951357995 0.4601010570874773 0.6207977546603366 0.6198216015396206 0.0026949121497638 0.0016667952436519 0.0 0.0003968253968253 0.069752342966223 0.0 315 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1088608 HSPG2 LRP1 HSPG2-LRP1 Mast Cells B Cells Mast Cells -> B Cells 0.0044654482356397 0.8349903778527206 0.6207977546603366 0.6198216015396206 0.0014804857410621 0.0016667952436519 0.0 0.0006200396825396 0.0784442998177833 0.0 112 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1088771 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0044610142564724 0.8818165186409654 0.7769451595923457 0.7827641335561659 0.0026436039558049 0.0005558995075445 0.0 0.0002376425855513 0.0351210427881834 0.0 526 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1088783 THBS2 CD36 THBS2-CD36 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0044605796145714 0.8858959974474152 0.6176321640000088 0.6198216015396206 0.0030563796158022 0.0007598956708367 0.0 0.0 0.0 0.0 129 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1088801 CD34 SELP CD34-SELP Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0044601830135995 0.8532069650852002 0.4623922682986163 0.2461374514707439 0.00083777361258 0.0096770075292062 0.0 0.0 0.0 0.0 41 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1088829 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0044595672747331 0.6589792304505506 0.2550748532138862 0.2461374514707439 0.0561415215593491 0.0003386430177035 0.0 0.0004655493482309 0.0663554439949999 0.0 179 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1088849 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0044591061227373 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0009153913192522 0.0028784826949613 0.0 0.0006410256410256 0.0545220353449996 0.0 390 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1088871 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0044586436377819 0.7840818683779507 0.4638256179742202 0.7204611100467462 0.0032417203409647 0.0009249287638231 0.0 0.0 0.0 0.0 37 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1088896 VWF ITGA9 VWF-ITGA9 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0044581343598562 0.8525936146535493 0.6252253442669611 0.6198216015396206 0.0002103933337194 0.0112932915661816 0.0 0.0 0.0 0.0 10 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1088961 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0044563327124531 0.8718210606749883 0.878254460598671 1.0 0.0017670878089588 0.0005788283879716 0.0 0.0 0.0 0.0 4019 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1088984 VWF ITGA9 VWF-ITGA9 B Cells B Cells B Cells -> B Cells 0.0044558064852842 0.6332974881236617 0.6252253442669611 1.0 0.00023686843287 0.0083442542366581 0.0 0.0 0.0 0.0 1418 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1089007 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0044553272281353 0.8624864526942296 0.7470475610360806 0.7827641335561659 0.0020100505037262 0.0007714919761827 0.0 0.0 0.0 0.0 23 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1089024 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0044546733198406 0.662063103571249 0.2491073778594529 0.2461374514707439 0.0967042147306326 0.0001990509171164 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1089138 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0044519446386038 0.9470274865242416 0.8341464445360613 0.8567148457705164 0.0061455194924501 0.0001871866311057 0.0 0.0 0.0 0.0 137 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1089153 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0044515384086496 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0020491452254277 0.0096442330625583 0.0 0.0 0.0 0.0 877 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1089156 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0044514621209422 0.6342079770588467 0.7754072541855492 0.909150863993142 0.0028649117803088 0.0006074333625108 0.0 0.0 0.0 0.0 1572 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1089166 VWF ITGA9 VWF-ITGA9 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0044512870999313 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0001077515101466 0.1886404570313 0.0 0.0 0.0 0.0 684 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1089201 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0044503355383825 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0020491452254277 0.0011409783203169 0.0 0.0 0.0 0.0 1109 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1089204 C1QB LRP1 C1QB-LRP1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0044501681092074 0.8703788833238396 0.2550748532138862 0.2461374514707439 0.0419710388788557 0.0003386430177035 0.0 0.0 0.0 0.0 86 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1089255 VWF ITGA9 VWF-ITGA9 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0044486943084574 0.7158082793127664 0.7831795333113832 0.7204611100467462 0.0003457348439318 0.0055509879377996 0.0 0.0105708245243128 0.7883374084108001 0.0 43 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1089312 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0044471147637222 0.9275752708651288 0.7831795333113832 0.7827641335561659 0.000245041593909 0.0055509879377996 0.0 0.0005184929139301 0.0386675002604536 0.0 526 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1089341 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0044463844513424 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0021291294377375 0.0012252690191386 0.0 0.0 0.0 0.0 1109 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1089448 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0044439354773432 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0007263013575398 0.0267255153180908 0.0 0.0014957264957264 0.2368116088073767 0.0 351 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1089548 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0044413918281003 0.6342079770588467 0.4641352222874551 0.2461374514707439 0.0002327631000826 0.0455121851821151 0.0 0.0 0.0 0.0 211 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1089565 VWF SELP VWF-SELP Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.004441145027276 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0025256125075084 0.0010419094417808 0.0 0.0002154243860404 0.1269701702190959 0.0 422 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1089644 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0044392800863967 0.7797135509308979 0.7832252605020791 1.0 0.0009209869688402 0.00136079311934 0.0 0.0002061248527679 0.0303005455379403 0.0 1132 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1089645 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.004439277222861 0.8949858186325867 0.7470475610360806 0.7827641335561659 0.001895566065636 0.0007714919761827 0.0 0.0 0.0 0.0 179 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1089722 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0044374615445787 0.4619393085577573 0.2491073778594529 0.3990376746076917 0.0835287751665837 0.0001990509171164 0.0 0.0006443298969072 1.0 0.0 97 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1089768 MMRN2 CD93 MMRN2-CD93 T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes -> 11q13 Invasive Tumor Cells (G1/S) 0.0044360794791239 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0031934983073077 0.0007261054236978 0.0 0.0 0.0 0.0 81 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1089807 VEGFC FLT1 VEGFC-FLT1 B Cells Mast Cells B Cells -> Mast Cells 0.0044349345143475 0.7745997874735252 0.8331580262014722 0.6198216015396206 0.0012459853895406 0.001526625481682 0.0 0.0017182130584192 0.8080155138978672 0.0 97 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1089819 CD34 SELP CD34-SELP Macrophages B Cells Macrophages -> B Cells 0.004434588986478 0.8963354148873306 0.7760344326192508 0.6198216015396206 0.0038492365148421 0.0004582650848664 0.0 0.0 0.0 0.0 1074 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1089845 CCN1 CAV1 CCN1-CAV1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0044340174590109 0.8749036366850302 0.252518874138558 0.2461374514707439 0.0004337320404416 0.0322196586137726 0.0 0.0008130081300813 0.1422732918400103 0.0 41 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1089851 MMRN2 CD93 MMRN2-CD93 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.004433944121658 0.7856500335676843 0.6587114738285964 0.6198216015396206 0.0005542667491398 0.0042738820064046 0.0 0.0 0.0 0.0 160 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1089854 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0044338050902111 0.7856500335676843 0.6347970925105053 0.6198216015396206 0.0005542667491398 0.0044340558155446 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1089899 VWF SELP VWF-SELP T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0044327171924042 0.6332974881236617 0.7760344326192508 0.9318789094584046 0.0036144684673052 0.0004582650848664 0.0 2.721829069134458e-05 0.0136890650176534 0.0 5010 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1089963 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0044310838846014 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.000716220684292 0.0058437228618857 0.0 0.0 0.0 0.0 453 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1089969 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) T Lymphocytes 11q13 Invasive Tumor Cells (Mitotic) -> T Lymphocytes 0.0044307885070756 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.000393370777602 0.0063011237754475 0.0 0.0 0.0 0.0 83 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1090010 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages T Lymphocytes Macrophages -> T Lymphocytes 0.0044296169629516 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0002750231449378 0.0083242517891534 0.0 8.655587514647917e-05 0.0101258456728492 0.0 3576 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1090025 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0044294035052427 0.785133132759182 0.6331674633943454 0.6198216015396206 0.001039571291679 0.0023576674662702 0.0 0.0009259259259259 0.4439844559200745 0.0 162 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1090077 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0044279954862218 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0018436902762588 0.0022515473538965 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1090095 MMP2 PECAM1 MMP2-PECAM1 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0044275572543173 0.8560892486218385 0.6331674633943454 0.6198216015396206 0.0006966068981631 0.0032187363284526 0.0 0.0003472222222222 0.1010196613319872 0.0 144 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1090331 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0044217143367168 0.250044481781731 0.6587114738285964 0.2461374514707439 0.0070431301838115 0.0026174949623928 0.0 0.0 0.0 0.0 373 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1090366 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0044208716511187 0.6301823358791634 0.6587114738285964 0.9592803095773328 0.000716220684292 0.0026174949623928 0.0 0.0 0.0 0.0 1476 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1090390 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0044203784369763 0.6301823358791634 0.7461459456652184 0.6198216015396206 0.0024635726452692 0.0010390313650636 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1090434 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0044190834606932 0.6160088550075702 0.4600037439857229 0.6198216015396206 0.0001971810371238 0.0215025911544899 0.0 0.0001003411599438 0.0120545528619744 0.0 453 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1090440 MMRN2 CLEC14A MMRN2-CLEC14A B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0044189916032908 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0003083910058032 0.0076236123034427 0.0 0.0 0.0 0.0 968 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1090466 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells B Cells 11q13 Invasive Tumor Cells -> B Cells 0.0044184766336971 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0034559943126159 0.0007053434767499 0.0 0.0 0.0 0.0 570 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1090503 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.004417531208369 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0002705513462707 0.0083242517891534 0.0 9.48586605957124e-05 0.0110971572559328 0.0 753 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1090546 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0044164512971552 0.7840818683779507 0.7754072541855492 0.6198216015396206 0.0032417203409647 0.0006074333625108 0.0 0.0 0.0 0.0 144 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1090561 MMRN2 CD93 MMRN2-CD93 Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0044160422838227 0.6301823358791634 0.7779918296243433 0.909150863993142 0.0015409900107563 0.001079730675535 0.0 0.0 0.0 0.0 1572 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1090607 A2M LRP1 A2M-LRP1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0044148620887098 0.8392912392980421 0.7346293219749174 0.7204611100467462 0.0005164482812395 0.0032275631628407 0.0 0.0 0.0 0.0 50 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1090611 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0044147184883724 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.000716220684292 0.003263637675389 0.0 0.0 0.0 0.0 193 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1090710 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0044122771409144 0.0 0.7763400818577846 0.2461374514707439 0.0096292529477205 1.0 0.000400998812763 0.0292792792792792 0.464860680910188 0.0135135135135135 74 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1090722 C1QB LRP1 C1QB-LRP1 B Cells Mast Cells B Cells -> Mast Cells 0.0044120774918541 0.8703788833238396 0.8755243548400705 0.6198216015396206 0.0037630364713574 0.0004150165744076 0.0 0.0006443298969072 0.0797519996097386 0.0 97 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1090817 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0044094356307519 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.000245041593909 0.0083442542366581 0.0 0.0 0.0 0.0 791 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1090846 MMRN2 CD93 MMRN2-CD93 Macrophages 11q13 Invasive Tumor Cells (Mitotic) Macrophages -> 11q13 Invasive Tumor Cells (Mitotic) 0.0044086759450902 0.893316592628645 0.6587114738285964 0.6198216015396206 0.0007691101630988 0.0026174949623928 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1090886 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0044077515354839 0.7463064942968751 0.8347945881127203 0.7827641335561659 0.0012430446376512 0.0012097093680331 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1090915 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Macrophages Dendritic Cells -> Macrophages 0.0044069774642968 0.6301823358791634 0.9195415044619336 0.6198216015396206 0.0015409900107563 0.0013235329769289 0.0 0.0 0.0 0.0 1633 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1090955 THBS2 CD36 THBS2-CD36 Macrophages B Cells Macrophages -> B Cells 0.0044055400083552 0.8858959974474152 0.6176321640000088 0.6198216015396206 0.0030563796158022 0.0007053434767499 0.0 7.759155803848541e-05 0.0374888518963341 0.0 1074 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1090971 A2M LRP1 A2M-LRP1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.004405161938982 0.919551140852988 0.2550748532138862 0.2461374514707439 0.037376181609614 0.0003386430177035 0.0 0.0 0.0 0.0 19 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1091005 MMP2 PECAM1 MMP2-PECAM1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0044041161070024 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0024819960935566 0.0076066460958003 0.0 0.0 0.0 0.0 211 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1091029 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0044035388595122 0.4601010570874773 0.8755243548400705 0.2461374514707439 0.0177188549930425 0.0004150165744076 0.0 0.0 0.0 0.0 34 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1091101 A2M LRP1 A2M-LRP1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0044016948186764 0.8392912392980421 0.2550748532138862 0.2461374514707439 0.0005164482812395 0.0267255153180908 0.0 0.0 0.0 0.0 41 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1091123 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0044012630639041 0.6626993710110988 0.2550748532138862 0.2461374514707439 0.0515877972474039 0.0003386430177035 0.0 0.0010474860335195 0.0650612443179847 0.0 179 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1091145 CCN1 CAV1 CCN1-CAV1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0044004539375046 0.2542249848376565 0.62431395375366 0.2461374514707439 0.0014656941948563 0.0126805820762719 0.0 0.0 0.0 0.0 74 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1091151 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0044002654697738 0.7800321422220979 0.7841656220878274 0.6198216015396206 0.0014623066995027 0.001309307002134 0.0 0.0 0.0 0.0 137 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1091158 THBS2 CD36 THBS2-CD36 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0044001340365311 0.6242573126045354 0.8765901449012573 0.6198216015396206 0.004981832968137 0.0004295051170816 0.0 0.0002759381898454 0.0334197901514687 0.0 151 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1091162 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0044000686438533 0.8818165186409654 0.8755243548400705 0.8567148457705164 0.0026436039558049 0.0004150165744076 0.0 0.0006082725060827 0.0845475298030043 0.0 137 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1091282 VWF LRP1 VWF-LRP1 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0043971320444613 0.8525936146535493 0.6207977546603366 0.6198216015396206 0.0002103933337194 0.0104714078116759 0.0 0.0001325205406838 0.0111259007619061 0.0 343 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1091318 CD48 CD2 CD48-CD2 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0043959287335611 0.7453966474499909 0.7763428264267787 0.7827641335561659 0.006326966401379 0.0002517784065132 0.0 0.0 0.0 0.0 527 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1091420 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.004393500491645 0.7463064942968751 0.7461459456652184 1.0 0.0012430446376512 0.0010390313650636 0.0 0.0001892983341746 0.0180111763789729 0.0 1132 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1091463 VWF ITGA9 VWF-ITGA9 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0043923650357933 0.8525936146535493 0.2531744428854943 0.2461374514707439 0.0002103933337194 0.0642389143033604 0.0 0.0 0.0 0.0 41 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1091520 C3 LRP1 C3-LRP1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0043911780182505 0.6319926036888139 0.7769451595923457 0.6198216015396206 0.0042375227960614 0.0005558995075445 0.0 0.0012773722627737 0.2863667235116125 0.0 137 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1091541 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Pericytes CXCL14+ Fibroblasts -> Pericytes 0.0043906051853962 0.6303682835571691 0.773263018678637 0.9429656149619918 0.000219642761279 0.0070956399217802 0.0 0.0001183817218621 0.0148573255539474 0.0 3218 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1091674 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0043868056094286 0.6303682835571691 0.8445107771175474 0.6198216015396206 9.902323108165852e-05 0.0218093597373452 0.0 0.0 0.0 0.0 162 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1091685 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0043864511785797 0.6301823358791634 0.6587114738285964 0.9592803095773328 0.0024635726452692 0.0007261054236978 0.0 0.0001672240802675 0.0204769722325195 0.0 1495 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1091729 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043849901384525 0.255669001367946 0.6631822525600675 0.2461374514707439 0.0061207051981986 0.0027830389352876 0.0 0.0 0.0 0.0 26 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1091780 CD48 CD2 CD48-CD2 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043839352711242 0.7453966474499909 0.6614977577544194 0.6198216015396206 0.006326966401379 0.0003671083100858 0.0 0.0 0.0 0.0 32 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1091785 CD34 SELP CD34-SELP Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0043837532964795 0.7168245244832976 0.8347297932672282 0.7204611100467462 0.0018206581062216 0.0009042150166242 0.0 0.0 0.0 0.0 48 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1091801 A2M LRP1 A2M-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043830607049428 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.0021905373114471 0.0018097844702233 0.0 0.0 0.0 0.0 8 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1091831 C3 LRP1 C3-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0043817818670384 0.7796725988275006 0.6207977546603366 0.6198216015396206 0.000819605673545 0.0028784826949613 0.0 0.0 0.0 0.0 30 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1091854 MMRN2 CD93 MMRN2-CD93 B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0043810879782065 0.6301823358791634 0.7779918296243433 0.8693461273411047 0.0003083910058032 0.0053794918117879 0.0 0.0013888888888888 0.1676557467439522 0.0 360 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1091872 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0043805190914527 0.255669001367946 0.4596166826058663 0.2461374514707439 0.0002269856810233 0.1076178292491983 0.0 0.0025536261491317 0.2139446609499144 0.0 89 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1092028 COL4A1 CD93 COL4A1-CD93 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0043762293107405 0.8684504425765611 0.7461459456652184 0.6198216015396206 0.0016831757123532 0.0010390313650636 0.0 0.0005213764337851 0.0496074249659302 0.0 137 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1092064 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0043750690616096 0.6626993710110988 0.7769451595923457 0.6198216015396206 0.0039530346951707 0.0005558995075445 0.0 0.0 0.0 0.0 21 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1092067 MMRN2 CD93 MMRN2-CD93 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0043750505639847 0.8571898293845529 0.4630027772793905 0.7204611100467462 0.0004196880356983 0.0058437228618857 0.0 0.0 0.0 0.0 66 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1092122 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0043738344559585 0.8640667164982425 0.8537710813834968 0.8567148457705164 0.002676946692949 0.0004138063814779 0.0 0.0 0.0 0.0 137 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1092134 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0043736245199705 0.6303682835571691 0.773263018678637 0.8875000050982297 0.000219642761279 0.0073658308476012 0.0 0.0001672017121455 0.0304431688213212 0.0 1424 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1092137 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0043735762883102 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0002705513462707 0.0073658308476012 0.0 0.0008478168715557 0.1543658364447292 0.0 337 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1092187 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Macrophages CAFs, Invasive Associated -> Macrophages 0.0043719250981208 0.6301823358791634 0.9195415044619336 0.6198216015396206 0.00146889578236 0.0013235329769289 0.0 0.0 0.0 0.0 1361 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1092274 THBS2 CD36 THBS2-CD36 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0043694833179129 0.724503440376099 0.7763054211764489 0.7204611100467462 0.0009736808737186 0.0017638974017382 0.0 0.0 0.0 0.0 43 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1092291 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0043689106629922 0.940547666092272 0.7779918296243433 0.6198216015396206 0.0001298888146421 0.0118035014556376 0.0 0.0 0.0 0.0 1881 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1092296 VWF SELP VWF-SELP Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043688056175724 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0020251995753771 0.0010419094417808 0.0 0.0002345032439615 0.1382151637982592 0.0 1163 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1092383 HSPG2 LRP1 HSPG2-LRP1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0043666780978517 0.9253089325030373 0.7769451595923457 0.7827641335561659 0.0022161183602947 0.0005558995075445 0.0 0.0002327746741154 0.0344016173306973 0.0 179 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1092420 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0043657191915275 0.2491449441646273 0.4623922682986163 0.2461374514707439 0.0108445362943651 0.0022515473538965 0.0 0.0 0.0 0.0 272 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1092480 COL4A2 CD93 COL4A2-CD93 B Cells Plasma Cells B Cells -> Plasma Cells 0.0043638190471364 0.7783550150988336 0.4630027772793905 0.6198216015396206 0.0033449520260795 0.0009242223287825 0.0 0.0003367003367003 0.0642090196180288 0.0 297 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1092499 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043632374459935 0.4619393085577573 0.6331674633943454 0.6198216015396206 0.0051428381563772 0.0007400708115376 0.0 0.0 0.0 0.0 8 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1092594 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043607671434248 0.4604235282221027 0.6587114738285964 0.2461374514707439 0.0126864732057784 0.0007261054236978 0.0 0.0 0.0 0.0 26 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1092632 VWF SELP VWF-SELP Macrophages CAFs, Invasive Associated Macrophages -> CAFs, Invasive Associated 0.0043595538482002 0.9011206516381156 0.6572093097629401 0.6198216015396206 0.0008850282134344 0.002113171886167 0.0 0.0 0.0 0.0 1354 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1092657 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0043587649692938 0.6213271600240247 0.252518874138558 0.2461374514707439 0.0093830613230477 0.0018925243453249 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1092749 VWF LRP1 VWF-LRP1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0043564489025175 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0001077515101466 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1092769 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0043555857372715 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0024635726452692 0.0007880862995141 0.0 0.0 0.0 0.0 339 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1092791 VWF SELP VWF-SELP Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043550303698358 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.0019871862905238 0.0010419094417808 0.0 0.0 0.0 0.0 209 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1092817 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043541413556536 0.6303682835571691 0.663300745568453 0.6198216015396206 9.902323108165852e-05 0.0265498740402422 0.0 0.0 0.0 0.0 1 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1092879 THBS2 CD36 THBS2-CD36 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0043519494872962 0.8581959463413404 0.7373999388878224 0.7204611100467462 0.0002636300075004 0.0056518532344078 0.0 0.0 0.0 0.0 66 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1093068 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0043468466463786 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0007263013575398 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1093083 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Pericytes Plasma Cells -> Pericytes 0.0043464199083272 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0002705513462707 0.0070956399217802 0.0 0.0004214075010535 0.0528881345493396 0.0 452 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1093111 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0043454731682068 0.4619393085577573 0.2491073778594529 0.2461374514707439 0.1194227711616854 0.0001990509171164 0.0 0.0002717391304347 0.44733521301218 0.0 230 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1093126 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0043450833757077 0.4629984640915818 0.2550748532138862 0.2461374514707439 0.0683610513379333 0.0003386430177035 0.0 0.0007149666348903 0.1019052624174879 0.0 1049 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1093192 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0043438569393626 0.8640667164982425 0.6331674633943454 0.6198216015396206 0.002676946692949 0.0007400708115376 0.0 0.0 0.0 0.0 409 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1093350 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0043403813144007 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.000895875398841 0.0040904475843412 0.0 0.0 0.0 0.0 5 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1093370 CD34 SELP CD34-SELP Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0043399233923493 0.7871981482311898 0.7760344326192508 0.6198216015396206 0.0038506427265089 0.0004582650848664 0.0 0.0 0.0 0.0 144 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1093462 CD34 SELP CD34-SELP CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0043372754100596 0.9303167350027568 0.6572093097629401 0.6198216015396206 0.0016860250240652 0.0010419094417808 0.0 0.0 0.0 0.0 409 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1093660 VWF SELP VWF-SELP CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0043319755697236 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0016171311116606 0.0022515473538965 0.0 0.0 0.0 0.0 253 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1093718 C1QB LRP1 C1QB-LRP1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043304412505468 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0012213774841743 0.0018097844702233 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1093725 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0043301889958856 0.6332974881236617 0.6252253442669611 1.0 0.0003521782369754 0.0047273851759697 0.0 0.0 0.0 0.0 1846 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1093791 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0043286180845329 0.8949858186325867 0.896164124004365 0.8875000050982297 0.001895566065636 0.0004874986369898 0.0 0.0 0.0 0.0 1462 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1093813 CD48 CD2 CD48-CD2 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0043281758036007 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0081474500750471 0.0002517784065132 0.0 0.0 0.0 0.0 1490 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1093816 VEGFC FLT1 VEGFC-FLT1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0043280948760908 0.4636527906642655 0.777821334064334 0.6198216015396206 0.0023125636768155 0.001271575589586 0.0 0.0 0.0 0.0 315 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1093824 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.004327886168022 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0012814156885439 0.0028784826949613 0.0 0.0 0.0 0.0 3 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1093949 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0043239262965347 0.6630837220165452 0.4630027772793905 0.6198216015396206 0.0037159398684439 0.0009242223287825 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1093970 A2M LRP1 A2M-LRP1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0043233469162982 0.4648000335061383 0.6207977546603366 0.6198216015396206 0.0021905373114471 0.0016667952436519 0.0 0.0001322751322751 0.0265618597702342 0.0 315 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1093982 C3 LRP1 C3-LRP1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.004322932357642 0.7148920381722296 0.7769451595923457 0.7204611100467462 0.0029337538459309 0.0005558995075445 0.0 0.0 0.0 0.0 43 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1094040 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0043213981236347 0.4619393085577573 0.930308383061206 0.7204611100467462 0.0051428381563772 0.0004089864655001 0.0 0.0 0.0 0.0 306 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1094076 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0043203149771993 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0015409900107563 0.0109188419829382 0.0 0.0004432624113475 0.0638090445307397 0.0 752 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1094110 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0043196643520186 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0024635726452692 0.0009436211854823 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1094124 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0043193239550681 0.255669001367946 0.7462743270426613 0.2461374514707439 0.0061207051981986 0.0022591041672132 0.0 0.0 0.0 0.0 84 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1094126 VEGFC FLT1 VEGFC-FLT1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0043193015047823 0.8317042416754105 0.4630488285702799 0.7204611100467462 0.0005440770361181 0.0043013567716651 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1094138 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0043189954712257 0.6342079770588467 0.7470475610360806 0.6198216015396206 0.0028649117803088 0.0007714919761827 0.0 0.0 0.0 0.0 161 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1094171 COL4A2 CD93 COL4A2-CD93 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043183250074802 0.4630253981438691 0.6587114738285964 0.6198216015396206 0.0047240947268779 0.0007261054236978 0.0 0.0 0.0 0.0 8 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1094185 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0043178947552949 0.6303682835571691 0.4614667734221426 0.7204611100467462 9.902323108165852e-05 0.0312252462757311 0.0 0.0 0.0 0.0 66 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1094195 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0043175945690863 0.6332974881236617 0.6572093097629401 0.9592803095773328 0.0015572459193676 0.0010419094417808 0.0 0.0 0.0 0.0 1495 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1094261 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0043159107791804 0.9184503888425788 0.8923034233058523 0.8875000050982297 0.0004696576149175 0.00189193058407 0.0 0.0 0.0 0.0 1424 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1094267 VWF SELP VWF-SELP Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0043156893502906 0.7848266128497919 0.7478729882108823 1.0 0.0004024409845247 0.0027351735586246 0.0 0.0002810793446835 0.0154280256256502 0.0 1132 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1094412 VWF SELP VWF-SELP CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0043116768922334 0.6332974881236617 0.6572093097629401 0.9161861017439124 0.0016171311116606 0.0010419094417808 0.0 0.0 0.0 0.0 460 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1094423 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0043113910534833 0.6332974881236617 0.6572093097629401 0.9592803095773328 0.0003521782369754 0.0045674276780054 0.0 0.0001539788125153 0.0259158709361892 0.0 1476 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1094449 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0043106688937586 0.9275752708651288 0.7292496872084557 0.7204611100467462 0.000245041593909 0.0053724660607752 0.0 0.0 0.0 0.0 285 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1094550 CD34 SELP CD34-SELP T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0043080024140205 0.633566764858408 0.8819126042133903 0.6198216015396206 0.015517736049123 0.0001189339410417 0.0 0.0 0.0 0.0 1880 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1094584 HSPG2 LRP1 HSPG2-LRP1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0043070212896722 0.9253089325030373 0.8755243548400705 0.8567148457705164 0.0022161183602947 0.0004150165744076 0.0 0.0003367003367003 0.0468000468000468 0.0 165 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1094671 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0043048168350909 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0015572459193676 0.0022515473538965 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1094720 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts CAFs, DCIS Associated CXCL14+ Fibroblasts -> CAFs, DCIS Associated 0.0043033713057479 0.940547666092272 0.4630027772793905 0.7204611100467462 0.0001298888146421 0.0155837683010033 0.0 0.0 0.0 0.0 10961 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1094745 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Myoepithelial Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myoepithelial Cells 0.0043025214120882 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.000393370777602 0.0056518532344078 0.0 0.0 0.0 0.0 714 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1094795 C1QB LRP1 C1QB-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0043011384588093 0.7452691992612583 0.6207977546603366 0.6198216015396206 0.0012199377895337 0.0018097844702233 0.0 0.0 0.0 0.0 32 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1095026 MMRN2 CD93 MMRN2-CD93 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0042950336841514 0.8571898293845529 0.6587114738285964 0.6198216015396206 0.0004196880356983 0.0042738820064046 0.0 0.0 0.0 0.0 144 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1095032 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.004294899008402 0.8571898293845529 0.6347970925105053 0.6198216015396206 0.0004196880356983 0.0044340558155446 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1095042 CD34 SELP CD34-SELP Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0042944364530029 0.2491449441646273 0.6572093097629401 0.2461374514707439 0.0003767662344862 0.04130664769978 0.0 0.0 0.0 0.0 184 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1095047 JAG1 NOTCH2 JAG1-NOTCH2 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0042942144183792 0.8630183004227985 0.8445107771175474 0.9318789094584046 0.0001109003117737 0.0083242517891534 0.0 5.2538568085208e-05 0.0061462891040382 0.0 4985 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1095117 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0042915530681059 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0049987108499989 0.0032187363284526 0.0 0.0003401360544217 0.0989580355905181 0.0 147 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1095129 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0042910967059458 0.6626993710110988 0.7769451595923457 0.6198216015396206 0.0035190936623492 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1095147 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0042906384578551 0.6160088550075702 0.7462743270426613 0.6198216015396206 0.0009692519480124 0.0022591041672132 0.0 0.0 0.0 0.0 23 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1095249 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0042875443620003 0.7835752212271604 0.8341464445360613 0.7827641335561659 0.0064863313435223 0.0001871866311057 0.0 0.0 0.0 0.0 23 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1095306 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0042860698344473 0.6301823358791634 0.6347970925105053 0.8693461273411047 0.0003083910058032 0.0057802287131517 0.0 0.0 0.0 0.0 360 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1095310 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0042859951385423 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0008320501336843 0.0023576674662702 0.0 6.318449873631003e-05 0.0302971701175451 0.0 1187 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1095313 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0042859519100398 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.00146889578236 0.0109188419829382 0.0 0.0 0.0 0.0 155 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1095406 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.00428275191662 0.6303642896310324 0.7167436199046466 0.6198216015396206 0.0008320501336843 0.0026482500471321 0.0 0.0001655629139072 0.151209196989688 0.0 453 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1095446 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0042816931557557 0.2486570577556728 0.6572093097629401 0.2461374514707439 0.0033537993821664 0.0045674276780054 0.0 0.0 0.0 0.0 373 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1095477 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.004281072356841 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.00146889578236 0.001079730675535 0.0 0.0 0.0 0.0 917 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1095492 CD34 SELP CD34-SELP Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0042807079016448 0.8532069650852002 0.6572093097629401 0.6198216015396206 0.00083777361258 0.002113171886167 0.0 0.0 0.0 0.0 144 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1095494 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0042806219508348 0.4604235282221027 0.4630027772793905 0.2461374514707439 0.0126864732057784 0.0009242223287825 0.0 0.0 0.0 0.0 272 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1095567 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0042784805191045 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.002196330917593 0.00071798405859 0.0 0.000181752090149 0.096042119064511 0.0 917 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1095577 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0042781611334361 0.6301823358791634 0.6347970925105053 0.9161861017439124 0.00146889578236 0.0011388334136451 0.0 0.0 0.0 0.0 460 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1095596 VWF LRP1 VWF-LRP1 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0042777864478346 0.6332974881236617 0.7769451595923457 0.6198216015396206 0.0036144684673052 0.0005558995075445 0.0 6.295643414756989e-05 0.0078874667952434 0.0 361 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1095619 CD34 SELP CD34-SELP B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0042772297253065 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0006336851232098 0.0053213839468185 0.0 0.0 0.0 0.0 496 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1095628 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0042768594689528 0.743507317541692 0.878254460598671 0.7827641335561659 0.0020684923107111 0.0005788283879716 0.0 0.0 0.0 0.0 527 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1095692 VWF ITGA9 VWF-ITGA9 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0042750677697702 0.8525936146535493 0.7831795333113832 0.7827641335561659 0.0002103933337194 0.0055509879377996 0.0 0.0 0.0 0.0 23 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1095696 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0042750046717843 0.6213271600240247 0.252518874138558 0.2461374514707439 0.0083518627398662 0.0018925243453249 0.0 0.0 0.0 0.0 75 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1095726 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0042742073544804 0.6301823358791634 0.8514619504364779 0.6198216015396206 0.0031934983073077 0.0005740632036187 0.0 0.0 0.0 0.0 333 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1095764 VWF ITGA9 VWF-ITGA9 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.004273177272679 0.2486570577556728 0.8794572885381431 0.2461374514707439 0.0001077515101466 0.104965956217838 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1095794 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0042720597019304 0.255669001367946 0.9546923450729716 0.2461374514707439 0.0002269856810233 0.0445745465878424 0.0 0.0 0.0 0.0 11 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1095798 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0042720203111984 0.6301823358791634 0.8347945881127203 0.6198216015396206 0.0015409900107563 0.0012097093680331 0.0 0.0016556291390728 0.0878576783706111 0.0 151 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1095822 C1QB LRP1 C1QB-LRP1 Mast Cells B Cells Mast Cells -> B Cells 0.0042714443369788 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0012213774841743 0.0016667952436519 0.0 0.0005580357142857 0.098089232296251 0.0 112 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1095848 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0042706688593673 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0033537993821664 0.0047273851759697 0.0 0.0 0.0 0.0 26 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1095932 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0042683306076206 0.4619393085577573 0.8537710813834968 0.7204611100467462 0.0051428381563772 0.0004138063814779 0.0 0.0 0.0 0.0 48 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1095981 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0042666934944546 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.000219642761279 0.0083242517891534 0.0 0.0001265790739474 0.0148080088848439 0.0 1881 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1095993 C3 LRP1 C3-LRP1 B Cells Mast Cells B Cells -> Mast Cells 0.0042665088944522 0.6319926036888139 0.8755243548400705 0.6198216015396206 0.0042375227960614 0.0004150165744076 0.0 0.0002577319587628 0.0742860132344446 0.0 97 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1096022 CD34 SELP CD34-SELP Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0042655753016944 0.2491449441646273 0.7760344326192508 0.2461374514707439 0.0003767662344862 0.0335947364052305 0.0 0.0 0.0 0.0 74 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1096023 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0042655321272996 0.6659645551150886 0.6614977577544194 1.0 0.0037243679732516 0.0003671083100858 0.0 0.0 0.0 0.0 1846 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1096078 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0042639649142965 0.6332974881236617 0.7831795333113832 0.6198216015396206 0.0003521782369754 0.0055509879377996 0.0 0.0 0.0 0.0 21 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1096099 VWF ITGA9 VWF-ITGA9 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0042633880000034 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.00023686843287 0.0642389143033604 0.0 0.0 0.0 0.0 211 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1096120 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.004262795345426 0.6332974881236617 0.8347297932672282 0.6198216015396206 0.0020251995753771 0.0009042150166242 0.0 0.0 0.0 0.0 18 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1096149 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.004261984279182 0.6589792304505506 0.7769451595923457 0.6198216015396206 0.0033973231723341 0.0005558995075445 0.0 0.0 0.0 0.0 21 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1096184 COL4A1 CD93 COL4A1-CD93 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0042608990917055 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.0002970267018348 0.0053794918117879 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1096193 VWF SELP VWF-SELP Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0042606401055743 0.9011206516381156 0.4623922682986163 0.7204611100467462 0.0008850282134344 0.0022515473538965 0.0 0.0002788622420524 0.0269097521850264 0.0 326 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1096209 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells B Cells Mast Cells -> B Cells 0.0042600256657953 0.8624864526942296 0.7746834992804791 0.6198216015396206 0.0020100505037262 0.00071798405859 0.0 0.0 0.0 0.0 112 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1096268 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0042583079775065 0.2490567623945399 0.896164124004365 0.2461374514707439 0.000126812416921 0.0855781119790033 0.0 0.0 0.0 0.0 9 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1096339 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0042562633323634 0.6342079770588467 0.8923034233058523 0.6198216015396206 0.000895875398841 0.00189193058407 0.0 0.0 0.0 0.0 119 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1096344 MMRN2 CD93 MMRN2-CD93 Macrophages Mast Cells Macrophages -> Mast Cells 0.0042561477322666 0.893316592628645 0.8347945881127203 0.8567148457705164 0.0007691101630988 0.0012097093680331 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1096351 C3 LRP1 C3-LRP1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0042559579714276 0.8509500867818902 0.6207977546603366 0.6198216015396206 0.0006305085967044 0.0028784826949613 0.0 0.0 0.0 0.0 10 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1096489 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0042520595842925 0.6160088550075702 0.6632137581773894 0.9161861017439124 0.0001971810371238 0.0080072638027924 0.0 0.0 0.0 0.0 408 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1096492 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0042520212963164 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0048313935743179 0.0003375370073613 0.0 0.0 0.0 0.0 339 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1096512 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0042512248067518 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0016575843792215 0.0008609682710384 0.0 0.0001807664497469 0.0542316489458526 0.0 922 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1096521 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.004250880375455 0.9184503888425788 0.4641352222874551 0.7204611100467462 0.0004696576149175 0.0040904475843412 0.0 0.0 0.0 0.0 285 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1096523 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.004250857284223 0.6626993710110988 0.8755243548400705 0.6198216015396206 0.0039530346951707 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1096575 VWF SELP VWF-SELP Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0042493543578715 0.6332974881236617 0.8347297932672282 0.6198216015396206 0.0019871862905238 0.0009042150166242 0.0 0.0 0.0 0.0 151 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1096601 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.004248538756616 0.6249837837987587 0.7470475610360806 0.6198216015396206 0.00263399584678 0.0007714919761827 0.0 0.0 0.0 0.0 137 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1096627 VWF SELP VWF-SELP Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0042480370568528 0.7848266128497919 0.6572093097629401 0.6198216015396206 0.0004024409845247 0.0045674276780054 0.0 0.0 0.0 0.0 30 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1096658 VWF LRP1 VWF-LRP1 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0042470052714868 0.7158082793127664 0.7346293219749174 1.0 0.0003457348439318 0.0032275631628407 0.0 0.0004416961130742 0.0210250475769029 0.0 283 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1096698 THBS2 CD36 THBS2-CD36 Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0042457319910534 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0027791828709671 0.0007598956708367 0.0 0.0 0.0 0.0 422 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1096740 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages B Cells Macrophages -> B Cells 0.0042446792207636 0.8949858186325867 0.7746834992804791 0.6198216015396206 0.001895566065636 0.00071798405859 0.0 0.0001551831160769 0.0820024424414866 0.0 1074 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1096749 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0042444029199744 0.2486570577556728 0.7760344326192508 0.2461374514707439 0.0033537993821664 0.0036702914086929 0.0 0.0001007861318282 0.0420378820823239 0.0 902 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1096811 C1QB LRP1 C1QB-LRP1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0042425407595873 0.7452691992612583 0.6207977546603366 0.6198216015396206 0.0012199377895337 0.0016667952436519 0.0 0.0 0.0 0.0 144 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1096863 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Macrophages Mast Cells -> Macrophages 0.004241010812465 0.8516956437178343 0.8923034233058523 0.8567148457705164 0.000472352586488 0.00189193058407 0.0 0.0 0.0 0.0 165 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1096864 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0042409941598746 0.2491408586098361 0.7167436199046466 0.2461374514707439 0.0049987108499989 0.0026482500471321 0.0 0.0001403233048944 0.1281577724822792 0.0 13362 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1096925 MMP2 PECAM1 MMP2-PECAM1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0042392805075207 0.6303642896310324 0.6331674633943454 0.7917001487310438 0.0024819960935566 0.0007400708115376 0.0 0.0 0.0 0.0 42 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1096978 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0042380413717841 0.6301823358791634 0.8347945881127203 0.6198216015396206 0.00146889578236 0.0012097093680331 0.0 0.0 0.0 0.0 130 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1097002 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0042374584810326 0.6303642896310324 0.7841656220878274 0.6198216015396206 0.0014431743145616 0.001309307002134 0.0 0.0021739130434782 0.260011481026435 0.0 23 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1097020 VWF ITGA9 VWF-ITGA9 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0042370994165595 0.7848266128497919 0.6252253442669611 0.6198216015396206 0.0004024409845247 0.0047273851759697 0.0 0.0 0.0 0.0 32 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1097050 COL4A1 CD93 COL4A1-CD93 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0042362827630148 0.4604235282221027 0.8347945881127203 0.7204611100467462 0.0017253404164066 0.0012097093680331 0.0 0.0 0.0 0.0 48 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1097084 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0042355595855148 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0002269856810233 0.0521257226458961 0.0 0.0 0.0 0.0 15 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1097107 VWF ITGA9 VWF-ITGA9 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0042347467256471 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0036144684673052 0.0040430820937484 0.0 0.0 0.0 0.0 86 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1097158 VEGFC FLT1 VEGFC-FLT1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0042333418564325 0.8317042416754105 0.8331580262014722 1.0 0.0005440770361181 0.001526625481682 0.0 0.0 0.0 0.0 14 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1097185 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0042325771934164 0.4601010570874773 0.2550748532138862 0.2461374514707439 0.0587727051993296 0.0003386430177035 0.0 0.0 0.0 0.0 230 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1097203 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells Luminal-like Amorphous DCIS Cells -> Luminal-like Amorphous DCIS Cells 0.0042321955106133 0.2510234128936706 0.2562573700401372 1.0 0.0009262556366009 0.0096442330625583 0.0 2.742112394348024e-05 0.0279158148349664 0.0 77495 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1097223 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0042316310716489 0.8571898293845529 0.7830372268649692 0.7827641335561659 0.0004196880356983 0.0026038611777234 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1097258 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0042304142170881 0.4648000335061383 0.2550748532138862 0.3990376746076917 0.0357762282281787 0.0003386430177035 0.0 0.0004295532646048 0.070840868225681 0.0 97 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1097368 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Plasma Cells Basal-like Structured DCIS Cells -> Plasma Cells 0.0042274029347741 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0020491452254277 0.0009761781830445 0.0 0.0 0.0 0.0 79 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1097383 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0042269907420512 0.6301823358791634 0.7830372268649692 0.6198216015396206 0.000716220684292 0.0026038611777234 0.0 0.0 0.0 0.0 21 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1097387 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.004226801384698 0.6303682835571691 0.663300745568453 0.6198216015396206 9.902323108165852e-05 0.0222186841038061 0.0 0.0013227513227513 0.0523055619281838 0.0 144 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1097398 COL4A2 CD93 COL4A2-CD93 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0042262626115998 0.8355319038299565 0.7461459456652184 0.7827641335561659 0.001123788079051 0.0010390313650636 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1097710 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0042173233874049 0.9184503888425788 0.6571792026963191 0.6198216015396206 0.0004696576149175 0.0032020139126304 0.0 0.0 0.0 0.0 409 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1097712 VWF LRP1 VWF-LRP1 Myoepithelial Cells Myeloid Cells Myoepithelial Cells -> Myeloid Cells 0.0042172404556736 0.7158082793127664 0.7769451595923457 0.7204611100467462 0.0025256125075084 0.0005558995075445 0.0 0.0 0.0 0.0 51 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1097830 VWF SELP VWF-SELP Myeloid Cells Myoepithelial Cells Myeloid Cells -> Myoepithelial Cells 0.0042139451235902 0.7848266128497919 0.4623922682986163 0.7204611100467462 0.0004024409845247 0.0053213839468185 0.0 0.0 0.0 0.0 85 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1097858 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0042130193444458 0.7856500335676843 0.6347970925105053 0.6198216015396206 0.0005542667491398 0.003263637675389 0.0 0.0 0.0 0.0 170 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1097933 VWF SELP VWF-SELP Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0042110399396621 0.7848266128497919 0.7760344326192508 0.6198216015396206 0.0004024409845247 0.0036702914086929 0.0 0.0 0.0 0.0 162 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1097992 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0042092521560962 0.7160288858520609 0.8341464445360613 0.7204611100467462 0.0069047442087267 0.0001871866311057 0.0 0.0 0.0 0.0 38 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1098006 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0042087657966381 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0015409900107563 0.0011388334136451 0.0 0.0 0.0 0.0 209 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1098025 VWF LRP1 VWF-LRP1 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0042082207594111 0.9011206516381156 0.6207977546603366 0.6198216015396206 0.0008850282134344 0.0018097844702233 0.0 0.0 0.0 0.0 129 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1098078 CD34 SELP CD34-SELP Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0042063754687541 0.7168245244832976 0.6572093097629401 0.6198216015396206 0.0018206581062216 0.0010419094417808 0.0 0.0 0.0 0.0 8 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1098099 COL4A1 CD93 COL4A1-CD93 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.004205875877431 0.8684504425765611 0.6587114738285964 0.7917001487310438 0.0016831757123532 0.0007261054236978 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1098108 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0042056286632392 0.7468485855611411 0.6207977546603366 0.6198216015396206 0.0006689050756654 0.0028784826949613 0.0 0.0 0.0 0.0 30 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1098177 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0042036878504702 0.8560892486218385 0.6331674633943454 0.6198216015396206 0.0006966068981631 0.0023576674662702 0.0 0.0008333333333333 0.3995860103280671 0.0 30 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1098230 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0042017591102767 0.8516956437178343 0.4641352222874551 0.7204611100467462 0.000472352586488 0.0040904475843412 0.0 0.0 0.0 0.0 50 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1098294 C3 LRP1 C3-LRP1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0042002007837849 0.7148920381722296 0.8755243548400705 0.7204611100467462 0.0029337538459309 0.0004150165744076 0.0 0.0 0.0 0.0 48 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1098315 CCN1 CAV1 CCN1-CAV1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0041994475695561 0.8619922139338987 0.252518874138558 0.2461374514707439 0.0054092055025683 0.0018925243453249 0.0 0.0052631578947368 0.2915469066578714 0.0 19 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1098405 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0041969002250934 0.633566764858408 0.8347297932672282 0.6198216015396206 0.0018436902762588 0.0009042150166242 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1098416 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0041965344187948 0.724503440376099 0.8765901449012573 0.7204611100467462 0.0027791828709671 0.0004295051170816 0.0 0.0 0.0 0.0 38 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1098435 THBS2 CD36 THBS2-CD36 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0041960003676203 0.8581959463413404 0.6176321640000088 0.6198216015396206 0.0002636300075004 0.0063011237754475 0.0 0.0 0.0 0.0 343 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1098478 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.004194902401797 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0002269856810233 0.0491709261488903 0.0 0.0 0.0 0.0 15 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1098531 THBS2 CD36 THBS2-CD36 Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.004193343414438 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0027791828709671 0.0007053434767499 0.0 0.0 0.0 0.0 394 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1098615 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0041907821110721 0.2542249848376565 0.62431395375366 0.2461374514707439 0.0014656941948563 0.009460730808256 0.0 0.0015625 0.1939937994721869 0.0 64 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1098620 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0041906688770442 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.0003521782369754 0.0053724660607752 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1098627 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Luminal-like Amorphous DCIS Cells Dendritic Cells -> Luminal-like Amorphous DCIS Cells 0.0041905079747298 0.6301823358791634 0.4630027772793905 0.2461374514707439 0.0015409900107563 0.0048929293424311 0.0 0.0 0.0 0.0 752 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1098636 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0041902808892579 0.7205550478301406 0.7154802332407408 0.8293805866303694 0.0002165306714062 0.0058465532256424 0.0 0.0 0.0 0.0 324 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1098662 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells -> CXCL14+ Fibroblasts 0.0041894096090059 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0131302879503246 0.0001189339410417 0.0 9.314456035767511e-06 0.0585601137400518 0.0 4880 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1098672 VWF LRP1 VWF-LRP1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0041891848463208 0.6332974881236617 0.9078204025796472 0.6198216015396206 0.00023686843287 0.0064028969591119 0.0 4.261363636363636e-05 0.0044424857715497 0.0 800 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1098713 VWF LRP1 VWF-LRP1 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0041880025588623 0.7848266128497919 0.7346293219749174 0.7204611100467462 0.0004024409845247 0.0032275631628407 0.0 0.0015356265356265 0.0730969098803872 0.0 37 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1098715 CD34 SELP CD34-SELP Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0041879496348728 0.8532069650852002 0.8347297932672282 1.0 0.00083777361258 0.0009042150166242 0.0 0.0 0.0 0.0 14 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1098844 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0041840138800675 0.2485046029682279 0.7346293219749174 0.2461374514707439 0.0036991419150414 0.0032275631628407 0.0 0.0005514705882352 0.0511301195249202 0.0 272 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1098847 CCN1 CAV1 CCN1-CAV1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0041839519996356 0.7797135509308979 0.62431395375366 0.6198216015396206 0.0009209869688402 0.0019304335593669 0.0 0.0 0.0 0.0 144 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1098861 CD34 SELP CD34-SELP Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0041835830915418 0.8532069650852002 0.4623922682986163 0.7204611100467462 0.00083777361258 0.0022515473538965 0.0 0.0 0.0 0.0 50 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1098875 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0041831806000457 0.8624864526942296 0.4638256179742202 0.7204611100467462 0.0020100505037262 0.0009249287638231 0.0 0.0 0.0 0.0 50 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1098924 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Pericytes 11q13 Invasive Tumor Cells (G1/S) -> Pericytes 0.0041818995802545 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0001971810371238 0.0091569531245039 0.0 0.0 0.0 0.0 345 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1098927 DLL4 NOTCH4 DLL4-NOTCH4 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0041818494501864 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0002327631000826 0.0069630688870869 0.0 0.0 0.0 0.0 968 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1098973 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0041804942118801 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0031934983073077 0.0009242223287825 0.0 0.0007012622720897 0.0696590509931177 0.0 713 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1099054 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0041784672504968 0.2534163760166434 0.8923034233058523 0.2461374514707439 0.0050543892975134 0.00189193058407 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1099061 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0041781626435855 0.7800321422220979 0.2491073778594529 0.2461374514707439 0.0014623066995027 0.0076066460958003 0.0 0.0 0.0 0.0 211 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1099156 VWF LRP1 VWF-LRP1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0041755118944916 0.7848266128497919 0.2550748532138862 0.2461374514707439 0.0004024409845247 0.0267255153180908 0.0 0.0 0.0 0.0 122 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1099232 A2M LRP1 A2M-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0041729291643976 0.7460047258226694 0.6207977546603366 0.6198216015396206 0.0010163752993685 0.0018097844702233 0.0 0.0 0.0 0.0 32 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1099259 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0041723281223182 0.250044481781731 0.9195415044619336 0.2461374514707439 0.0070431301838115 0.0013235329769289 0.0 0.0 0.0 0.0 222 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1099350 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0041692777679524 0.6342079770588467 0.8341464445360613 0.6198216015396206 0.0085570823799139 0.0001871866311057 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1099352 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.004169268972194 0.6626993710110988 0.8755243548400705 0.6198216015396206 0.0035190936623492 0.0004150165744076 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1099373 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0041687496736189 0.250044481781731 0.9003264838243337 0.2461374514707439 7.058774627838557e-05 0.1341680150528327 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1099386 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.004168589891715 0.8516956437178343 0.6571792026963191 0.6198216015396206 0.000472352586488 0.0032020139126304 0.0 0.0 0.0 0.0 1 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1099402 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0041681109839982 0.8949858186325867 0.4638256179742202 0.7204611100467462 0.001895566065636 0.0009249287638231 0.0 0.0 0.0 0.0 326 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1099453 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0041670940316069 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0024635726452692 0.000671064546954 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1099454 COL4A2 CD93 COL4A2-CD93 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0041670663330621 0.8355319038299565 0.4630027772793905 0.2461374514707439 0.001123788079051 0.0048929293424311 0.0 0.0 0.0 0.0 41 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1099645 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0041615454422808 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.002196330917593 0.0006074333625108 0.0 0.0 0.0 0.0 917 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1099705 C3 LRP1 C3-LRP1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0041596801818988 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0013028322726017 0.0104714078116759 0.0 0.0006756756756756 0.0664893804262315 0.0 74 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1099735 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0041586889001816 0.7463064942968751 0.4630027772793905 0.2461374514707439 0.0012430446376512 0.0048929293424311 0.0 0.0 0.0 0.0 122 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1099793 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated -> Luminal-like Amorphous DCIS Cells 0.0041571773708899 0.6301823358791634 0.4630027772793905 0.2461374514707439 0.00146889578236 0.0048929293424311 0.0 0.0 0.0 0.0 155 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1099816 VWF SELP VWF-SELP Macrophages Mast Cells Macrophages -> Mast Cells 0.0041565590152832 0.9011206516381156 0.8347297932672282 0.8567148457705164 0.0008850282134344 0.0009042150166242 0.0 0.0 0.0 0.0 165 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1099823 VWF LRP1 VWF-LRP1 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0041563366031616 0.6332974881236617 0.8755243548400705 0.6198216015396206 0.0036144684673052 0.0004150165744076 0.0 0.0001365001365001 0.0167008756269091 0.0 333 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1099958 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0041529406139407 0.6249837837987587 0.8341464445360613 0.6198216015396206 0.0084812136822336 0.0001871866311057 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1100020 VWF LRP1 VWF-LRP1 Macrophages B Cells Macrophages -> B Cells 0.0041508889490819 0.9011206516381156 0.6207977546603366 0.6198216015396206 0.0008850282134344 0.0016667952436519 0.0 0.0001587100050787 0.0197258143056974 0.0 1074 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1100038 THBS2 CD36 THBS2-CD36 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.004150433093828 0.7809827257946271 0.7763054211764489 1.0 0.0004779710276932 0.0017638974017382 0.0 0.0001104240282685 0.0158578006104691 0.0 1132 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1100043 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Dendritic Cells Luminal-like Amorphous DCIS Cells -> Dendritic Cells 0.0041502039762627 0.2486570577556728 0.7760344326192508 0.2461374514707439 0.0033537993821664 0.0032078747392388 0.0 6.252344629235963e-05 0.0103749757800971 0.0 727 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1100138 CD34 SELP CD34-SELP B Cells Myeloid Cells B Cells -> Myeloid Cells 0.004147556403098 0.633566764858408 0.7478729882108823 0.6198216015396206 0.0006336851232098 0.0027351735586246 0.0 0.0 0.0 0.0 137 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1100169 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0041467140734574 0.6160088550075702 0.4596166826058663 0.2461374514707439 0.0009692519480124 0.0075270071967493 0.0 0.0003885003885003 0.1714973526270619 0.0 351 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1100170 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0041467107297379 0.255669001367946 0.9460955677032749 0.2461374514707439 0.0002269856810233 0.0376195773145198 0.0 0.0041322314049586 0.1503463565062837 0.0 11 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1100194 THBS2 CD36 THBS2-CD36 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0041458765727255 0.724503440376099 0.7373999388878224 1.0 0.0009736808737186 0.0009761781830445 0.0 0.0001472320376914 0.0567496609796436 0.0 283 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1100199 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0041458436413435 0.718867305289982 0.6331674633943454 0.6198216015396206 0.0024319941937022 0.0007400708115376 0.0 0.0 0.0 0.0 8 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1100260 VWF ITGA9 VWF-ITGA9 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0041439006261296 0.8525936146535493 0.7292496872084557 0.7204611100467462 0.0002103933337194 0.0053724660607752 0.0 0.0 0.0 0.0 50 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1100298 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0041421467458903 0.2486570577556728 0.4623922682986163 0.2461374514707439 0.0033537993821664 0.0053213839468185 0.0 5.442843341361528e-05 0.0248694351793934 0.0 13362 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1100299 VWF SELP VWF-SELP Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0041421299054489 0.7158082793127664 0.4623922682986163 0.8293805866303694 0.0003457348439318 0.0053213839468185 0.0 0.0 0.0 0.0 324 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1100327 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0041413511940213 0.7797135509308979 0.8617632615906476 0.7827641335561659 0.0009209869688402 0.0010414441948928 0.0 0.0 0.0 0.0 23 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1100344 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0041409830709596 0.6589792304505506 0.8755243548400705 0.6198216015396206 0.0033973231723341 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1100355 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.004140548139646 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0003083910058032 0.0058465532256424 0.0 0.0 0.0 0.0 496 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1100366 CCN1 CAV1 CCN1-CAV1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0041402274702533 0.8749036366850302 0.62431395375366 0.6198216015396206 0.0004337320404416 0.0034299077593249 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1100374 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Mast Cells 11q13 Invasive Tumor Cells -> Mast Cells 0.0041399644617931 0.6242573126045354 0.8765901449012573 0.6198216015396206 0.0034559943126159 0.0004295051170816 0.0 0.0 0.0 0.0 42 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1100397 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.0041392438579638 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0003521782369754 0.0036702914086929 0.0 0.0 0.0 0.0 1187 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1100437 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0041378741045759 0.2491449441646273 0.8347297932672282 0.2461374514707439 0.0108445362943651 0.0009042150166242 0.0 0.0 0.0 0.0 34 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1100463 CD34 SELP CD34-SELP B Cells Macrophages B Cells -> Macrophages 0.0041368553021098 0.633566764858408 0.941479368642921 0.6198216015396206 0.0006336851232098 0.0021392900294222 0.0 0.0 0.0 0.0 1065 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1100566 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0041331676879575 0.2490567623945399 0.7754072541855492 0.2461374514707439 0.000126812416921 0.0826982152707935 0.0 0.0 0.0 0.0 684 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1100583 THBS2 CD36 THBS2-CD36 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0041324147633783 0.724503440376099 0.8587566561291643 0.7204611100467462 0.0009736808737186 0.0011409783203169 0.0 0.0 0.0 0.0 306 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1100585 VWF SELP VWF-SELP Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0041323778555614 0.7848266128497919 0.941479368642921 0.7827641335561659 0.0004024409845247 0.0021392900294222 0.0 0.0 0.0 0.0 162 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1100600 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0041318756791665 0.6342079770588467 0.7470475610360806 0.6198216015396206 0.002196330917593 0.0007714919761827 0.0 0.0 0.0 0.0 143 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1100604 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.004131820414687 0.4593282471594782 0.6614977577544194 0.2461374514707439 0.0181222899145132 0.0003671083100858 0.0 0.0 0.0 0.0 26 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1100652 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.004130185201797 0.6160088550075702 0.6632137581773894 0.9592803095773328 0.0001971810371238 0.0064230792457803 0.0 0.0 0.0 0.0 1476 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1100704 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages B Cells Macrophages -> B Cells 0.0041286679666382 0.8949858186325867 0.7754072541855492 0.6198216015396206 0.001895566065636 0.0006074333625108 0.0 0.0 0.0 0.0 1074 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1100736 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0041278758692429 0.6319926036888139 0.6207977546603366 0.9592803095773328 0.0007263013575398 0.0018097844702233 0.0 0.0001003344481605 0.0354311052894345 0.0 1495 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1100737 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0041278603830179 0.2490567623945399 0.4641352222874551 0.2461374514707439 0.000126812416921 0.1370986982961073 0.0 0.0010672358591248 0.0343808004689338 0.0 937 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1100759 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0041272283289539 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0009153913192522 0.0018097844702233 0.0 0.0 0.0 0.0 409 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1100815 DLL4 NOTCH3 DLL4-NOTCH3 B Cells T Lymphocytes B Cells -> T Lymphocytes 0.0041255452483029 0.6342079770588467 0.7746834992804791 0.9318789094584046 0.0002327631000826 0.0046263543438723 0.0 0.0 0.0 0.0 4985 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1100866 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0041241094008667 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0028649117803088 0.0004874986369898 0.0 0.0 0.0 0.0 922 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1100902 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0041227232121602 0.250044481781731 0.8817184225858201 0.2461374514707439 7.058774627838557e-05 0.1281708518900828 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1100952 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells T Lymphocytes Plasma Cells -> T Lymphocytes 0.0041206864951397 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0002165306714062 0.0079745943515326 0.0 0.0 0.0 0.0 753 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1100981 COL4A2 CD93 COL4A2-CD93 Mast Cells B Cells Mast Cells -> B Cells 0.0041197300358156 0.8355319038299565 0.7779918296243433 0.6198216015396206 0.001123788079051 0.001079730675535 0.0 0.0 0.0 0.0 112 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1101051 VWF SELP VWF-SELP Myeloid Cells Dendritic Cells Myeloid Cells -> Dendritic Cells 0.0041175814434441 0.7848266128497919 0.7760344326192508 0.6198216015396206 0.0004024409845247 0.0032078747392388 0.0 0.0 0.0 0.0 170 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1101085 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.004116646197849 0.2486570577556728 0.7346293219749174 0.2461374514707439 0.0033537993821664 0.0032275631628407 0.0 4.1778074866310165e-05 0.0019886659305693 0.0 272 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1101101 A2M LRP1 A2M-LRP1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0041160781584623 0.7460047258226694 0.6207977546603366 0.6198216015396206 0.0010163752993685 0.0016667952436519 0.0 0.0 0.0 0.0 144 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1101179 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0041134983344941 0.6242573126045354 0.6176321640000088 0.8693461273411047 0.0020491452254277 0.0007053434767499 0.0 0.0 0.0 0.0 270 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1101238 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0041116217258932 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0028649117803088 0.0009249287638231 0.0 0.000697350069735 0.1231692577124912 0.0 239 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1101243 COL4A1 CD93 COL4A1-CD93 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0041114477674036 0.7463064942968751 0.7779918296243433 0.6198216015396206 0.0012430446376512 0.001079730675535 0.0 0.0014880952380952 0.2290553966026833 0.0 144 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1101322 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0041089652959099 0.6242573126045354 0.6176321640000088 1.0 0.000393370777602 0.0031731220372828 0.0 2.6847079037800687e-05 0.0120352767574336 0.0 1552 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1101369 COL4A2 CD93 COL4A2-CD93 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0041075542088879 0.7783550150988336 0.8817184225858201 0.6198216015396206 0.0033449520260795 0.0003375370073613 0.0 0.000125 0.0971122408961878 0.0 800 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1101375 A2M LRP1 A2M-LRP1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0041072864137352 0.8392912392980421 0.6207977546603366 0.6198216015396206 0.0005164482812395 0.0028784826949613 0.0 0.0 0.0 0.0 10 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1101409 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0041061306593454 0.8560892486218385 0.7841656220878274 0.7827641335561659 0.0006966068981631 0.001309307002134 0.0 0.0 0.0 0.0 23 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1101413 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0041060889200599 0.718867305289982 0.930308383061206 0.7204611100467462 0.0024319941937022 0.0004089864655001 0.0 0.0 0.0 0.0 306 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1101422 VWF SELP VWF-SELP CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0041058915484995 0.6332974881236617 0.8347297932672282 0.6198216015396206 0.0016171311116606 0.0009042150166242 0.0 0.0 0.0 0.0 130 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1101611 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0041004596064767 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0061207051981986 0.0015914585039484 0.0 0.0 0.0 0.0 1384 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1101612 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.004100449541586 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0020491452254277 0.0007598956708367 0.0 0.0002149613069647 0.1011109329079344 0.0 1163 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1101619 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Endothelial Cells Myeloid Cells -> Endothelial Cells 0.0041002954416355 0.6303682835571691 0.773263018678637 0.7827641335561659 0.0003788349535045 0.0032875740549697 0.0 5.175983436853002e-05 0.0083517072616156 0.0 460 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1101718 VWF LRP1 VWF-LRP1 Myoepithelial Cells Mast Cells Myoepithelial Cells -> Mast Cells 0.0040975095610775 0.7158082793127664 0.8755243548400705 0.7204611100467462 0.0025256125075084 0.0004150165744076 0.0 0.0008971291866028 0.1097643075742251 0.0 38 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1101789 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0040949243212717 0.255669001367946 0.6632137581773894 0.2461374514707439 0.0002269856810233 0.049767778498468 0.0 0.0002470355731225 0.0844232888406167 0.0 184 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1101811 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.004094117581309 0.8284725546778968 0.2491073778594529 0.2461374514707439 0.0012187708721425 0.0076066460958003 0.0 0.0 0.0 0.0 41 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1101825 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.004093286108104 0.6301823358791634 0.8514619504364779 0.6198216015396206 0.0024635726452692 0.0005740632036187 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1101865 CCN1 CAV1 CCN1-CAV1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0040921670837981 0.2542249848376565 0.62431395375366 0.2461374514707439 0.0014656941948563 0.0082011408892332 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1101894 COL4A2 CD93 COL4A2-CD93 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0040913488545526 0.4630253981438691 0.8817184225858201 0.7204611100467462 0.0047240947268779 0.0003375370073613 0.0 0.0 0.0 0.0 306 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1101946 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0040898898544205 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0002165306714062 0.0076236123034427 0.0 0.0 0.0 0.0 285 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1102006 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0040878853096775 0.6301823358791634 0.7461459456652184 0.6198216015396206 0.0015409900107563 0.0010390313650636 0.0 0.0 0.0 0.0 161 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1102021 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.004087293594553 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0016575843792215 0.0006800116997025 0.0 0.0001576789656259 0.0135478678046875 0.0 151 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1102030 THBS2 CD36 THBS2-CD36 Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0040870861621489 0.7809827257946271 0.6176321640000088 0.6198216015396206 0.0004779710276932 0.0032616151102094 0.0 0.0 0.0 0.0 160 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1102068 MMRN2 CD93 MMRN2-CD93 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0040860236617321 0.7856500335676843 0.6587114738285964 0.6198216015396206 0.0005542667491398 0.0026174949623928 0.0 0.0 0.0 0.0 30 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1102090 VWF ITGA9 VWF-ITGA9 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0040850767704609 0.7848266128497919 0.950463483645931 0.7827641335561659 0.0004024409845247 0.0019776346124415 0.0 0.0 0.0 0.0 527 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1102161 C3 LRP1 C3-LRP1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.004082850940891 0.2485046029682279 0.9078204025796472 0.2461374514707439 0.0013028322726017 0.0064028969591119 0.0 0.0 0.0 0.0 20 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1102223 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0040810302294946 0.8571898293845529 0.6347970925105053 0.6198216015396206 0.0004196880356983 0.003263637675389 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1102249 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0040801502170442 0.6332974881236617 0.8347297932672282 0.6198216015396206 0.0015572459193676 0.0009042150166242 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1102304 VWF SELP VWF-SELP Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0040788016127493 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0003457348439318 0.0045674276780054 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1102319 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0040782188910037 0.893316592628645 0.2491545808994955 0.2461374514707439 0.0007691101630988 0.0109188419829382 0.0 0.0 0.0 0.0 263 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1102403 VWF ITGA9 VWF-ITGA9 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0040762216149789 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0001077515101466 0.1112417752963437 0.0 0.0 0.0 0.0 184 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1102459 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0040745604078758 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0049987108499989 0.0023576674662702 0.0 2.771618625277162e-05 0.0132900003435055 0.0 902 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1102511 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0040732276313256 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0009692519480124 0.0015914585039484 0.0 0.0 0.0 0.0 339 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1102552 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0040714214993229 0.7158082793127664 0.2531744428854943 0.2461374514707439 0.0025256125075084 0.0040430820937484 0.0 8.666262241095416e-05 0.2326845148235901 0.0 1049 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1102557 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0040712694146469 0.2491449441646273 0.6572093097629401 0.2461374514707439 0.0108445362943651 0.0010419094417808 0.0 0.0 0.0 0.0 26 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1102563 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.004070999940457 0.7753420160918723 0.6207977546603366 0.6198216015396206 0.0009153913192522 0.0016667952436519 0.0 7.901390644753477e-05 0.0138887408561063 0.0 791 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1102569 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0040707097727291 0.9067635403815892 0.2491073778594529 0.2461374514707439 0.0411127335336962 0.0001990509171164 0.0 0.0 0.0 0.0 33 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1102595 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0040700041560859 0.6630837220165452 0.8817184225858201 0.6198216015396206 0.0037159398684439 0.0003375370073613 0.0 0.0 0.0 0.0 380 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1102605 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0040695979499359 0.2451358214448441 0.8445107771175474 0.2461374514707439 0.0010709508378277 0.0083242517891534 0.0 0.007078507078507 0.8280878698278522 0.0 74 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1102630 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0040688939221087 0.6342079770588467 0.8341464445360613 0.6198216015396206 0.0073929685753755 0.0001871866311057 0.0 0.0 0.0 0.0 333 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1102644 THBS2 CD36 THBS2-CD36 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0040683921756786 0.7809827257946271 0.6176321640000088 0.6198216015396206 0.0004779710276932 0.0031731220372828 0.0 0.0 0.0 0.0 30 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1102648 VWF ITGA9 VWF-ITGA9 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0040682997116898 0.7158082793127664 0.6252253442669611 0.6198216015396206 0.0003457348439318 0.0047273851759697 0.0 0.0 0.0 0.0 8 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1102658 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (Mitotic) -> CAFs, Invasive Associated 0.0040680605291672 0.6242573126045354 0.6176321640000088 0.9161861017439124 0.000393370777602 0.0032616151102094 0.0 0.0 0.0 0.0 458 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1102725 THBS2 CD36 THBS2-CD36 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0040659748363637 0.6242573126045354 0.7763054211764489 0.6198216015396206 0.0008527942416386 0.0017638974017382 0.0 0.0003041362530413 0.0436764727276181 0.0 137 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1102762 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0040648676018657 0.7797302331085993 0.0 0.2461374514707439 0.8713412494740926 0.0042544667714474 0.0006340376469696 0.0290697674418604 1.0 0.0116279069767441 86 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1102815 COL4A1 CD93 COL4A1-CD93 Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0040627306597736 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.0002970267018348 0.0058437228618857 0.0 0.0 0.0 0.0 66 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1102821 CD34 SELP CD34-SELP Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0040626172968619 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.0082993421103349 0.0001189339410417 0.0 0.0 0.0 0.0 1538 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1102839 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0040619895099279 0.8349903778527206 0.8755243548400705 1.0 0.0014804857410621 0.0004150165744076 0.0 0.0019841269841269 0.2757859900717045 0.0 14 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1102853 C3 LRP1 C3-LRP1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0040616265881918 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0334108479684367 0.0003386430177035 0.0 0.0 0.0 0.0 86 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1103050 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.004055665438287 0.718867305289982 0.8537710813834968 0.7204611100467462 0.0024319941937022 0.0004138063814779 0.0 0.0020833333333333 0.3032848077640911 0.0 48 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1103051 C3 LRP1 C3-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0040556590839412 0.7796725988275006 0.6207977546603366 0.6198216015396206 0.000819605673545 0.0018097844702233 0.0 0.0 0.0 0.0 32 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1103061 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0040553709494564 0.6301823358791634 0.7461459456652184 0.6198216015396206 0.00146889578236 0.0010390313650636 0.0 0.0 0.0 0.0 143 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1103111 COL4A1 CD93 COL4A1-CD93 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0040536881412229 0.4604235282221027 0.7461459456652184 0.7204611100467462 0.0017253404164066 0.0010390313650636 0.0 0.0 0.0 0.0 43 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1103113 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0040535553715843 0.6319926036888139 0.6207977546603366 0.9592803095773328 0.0004094805141934 0.0028784826949613 0.0 0.0001185636856368 0.0306759081836778 0.0 1476 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1103146 COL4A1 CD93 COL4A1-CD93 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0040525433039394 0.4604235282221027 0.4630027772793905 0.2461374514707439 0.0017253404164066 0.0048929293424311 0.0 0.0 0.0 0.0 271 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1103194 CD34 SELP CD34-SELP B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0040513562089091 0.633566764858408 0.4623922682986163 0.2461374514707439 0.0006336851232098 0.0096770075292062 0.0 0.0 0.0 0.0 211 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1103224 CD34 SELP CD34-SELP B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0040502237312959 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0006336851232098 0.002113171886167 0.0 0.0 0.0 0.0 968 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1103306 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) -> Dendritic Cells 0.0040473787814061 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0003521782369754 0.0032078747392388 0.0 0.0 0.0 0.0 193 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1103366 THBS2 CD36 THBS2-CD36 Myeloid Cells Basal-like Structured DCIS Cells Myeloid Cells -> Basal-like Structured DCIS Cells 0.0040455392052417 0.7809827257946271 0.6176321640000088 0.6198216015396206 0.0004779710276932 0.0030676679668133 0.0 0.0 0.0 0.0 162 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1103408 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0040445567575354 0.250044481781731 0.8347945881127203 0.2461374514707439 0.0070431301838115 0.0012097093680331 0.0 0.0 0.0 0.0 34 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1103409 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Plasma Cells B Cells -> Plasma Cells 0.004044547944396 0.6249837837987587 0.4638256179742202 0.6198216015396206 0.00263399584678 0.0009249287638231 0.0 0.0008417508417508 0.484610871072705 0.0 297 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1103454 VWF SELP VWF-SELP Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0040432784053844 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0003457348439318 0.0036702914086929 0.0 0.0018037518037518 0.752344635679687 0.0 126 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1103492 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Macrophages B Cells -> Macrophages 0.0040419605562769 0.6342079770588467 0.8818120773736414 0.6198216015396206 0.0002327631000826 0.0054043611446182 0.0 0.0 0.0 0.0 1065 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1103603 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0040391307612989 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0004094805141934 0.0267255153180908 0.0 0.0 0.0 0.0 19 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1103656 MMRN2 CD93 MMRN2-CD93 B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0040374787994539 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0003083910058032 0.0042738820064046 0.0 0.0 0.0 0.0 968 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1103660 MMRN2 CLEC14A MMRN2-CLEC14A B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0040373521996357 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0003083910058032 0.0044340558155446 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1103687 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0040366820954162 0.893316592628645 0.9003264838243337 0.8875000050982297 0.0007691101630988 0.0007880862995141 0.0 0.0 0.0 0.0 1462 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1103770 VWF SELP VWF-SELP Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0040341392893777 0.2486570577556728 0.8819126042133903 0.2461374514707439 0.0001077515101466 0.0741032966028748 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1103855 THBS2 CD36 THBS2-CD36 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0040311655502528 0.724503440376099 0.2562573700401372 0.2461374514707439 0.0009736808737186 0.0096442330625583 0.0 0.0 0.0 0.0 271 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1103880 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0040302775111949 0.6342079770588467 0.7480927101953669 0.6198216015396206 0.0002327631000826 0.006260692484444 0.0 0.0 0.0 0.0 137 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1103916 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0040292428537676 0.4604235282221027 0.8817184225858201 0.2461374514707439 0.0126864732057784 0.0003375370073613 0.0 0.0 0.0 0.0 1384 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1103955 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0040282374769092 0.9275752708651288 0.950463483645931 1.0 0.000245041593909 0.0019776346124415 0.0 2.2619828541699653e-05 0.0094900529961282 0.0 4019 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1103977 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0040279662034122 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0015409900107563 0.0007880862995141 0.0 0.0003615328994938 0.2414162669799348 0.0 922 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1104100 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0040235733163856 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0014431743145616 0.0076066460958003 0.0 0.0002136752136752 0.090179516409238 0.0 351 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1104149 EFNB2 PECAM1 EFNB2-PECAM1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0040217839452599 0.7800321422220979 0.6331674633943454 0.7917001487310438 0.0014623066995027 0.0007400708115376 0.0 0.0 0.0 0.0 42 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1104165 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0040214227170545 0.7296454584598743 0.8341464445360613 0.7204611100467462 0.0051524613572059 0.0001871866311057 0.0 0.0 0.0 0.0 48 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1104171 VWF SELP VWF-SELP CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0040213785720259 0.9275752708651288 0.6572093097629401 0.6198216015396206 0.000245041593909 0.0045674276780054 0.0 0.0 0.0 0.0 390 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1104324 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0040165687516955 0.2486570577556728 0.7478729882108823 0.2461374514707439 0.0033537993821664 0.0027351735586246 0.0 0.0 0.0 0.0 84 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1104418 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0040135742452052 0.255669001367946 0.8628183098412396 0.2461374514707439 0.0002269856810233 0.0339152418223636 0.0 0.0005980861244019 0.0456951602957775 0.0 684 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1104421 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0040134606174387 0.8349903778527206 0.7769451595923457 0.7827641335561659 0.0014804857410621 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1104467 MMRN2 CD93 MMRN2-CD93 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0040118793026779 0.893316592628645 0.7461459456652184 0.7827641335561659 0.0007691101630988 0.0010390313650636 0.0 0.0013966480446927 0.1621880240979953 0.0 179 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1104497 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0040110245210336 0.9275752708651288 0.6252253442669611 0.6198216015396206 0.000245041593909 0.0047273851759697 0.0 0.0002222716159146 0.0104225850229457 0.0 409 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1104550 VWF LRP1 VWF-LRP1 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0040091657444071 0.7158082793127664 0.2550748532138862 0.2461374514707439 0.0003457348439318 0.0267255153180908 0.0 8.386447500838645e-05 0.0045862168204618 0.0 271 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1104577 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Macrophages Myeloid Cells -> Macrophages 0.0040085073607813 0.7856500335676843 0.9195415044619336 0.7827641335561659 0.0005542667491398 0.0013235329769289 0.0 0.0 0.0 0.0 162 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1104628 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0040072181490933 0.2542249848376565 0.8818704453527788 0.2461374514707439 0.0014656941948563 0.0051192928876727 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1104650 COL4A1 CD93 COL4A1-CD93 Plasma Cells B Cells Plasma Cells -> B Cells 0.0040065079449825 0.4604235282221027 0.7779918296243433 0.6198216015396206 0.0017253404164066 0.001079730675535 0.0 0.0 0.0 0.0 315 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1104668 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Macrophages Luminal-like Amorphous DCIS Cells -> Macrophages 0.0040062056116533 0.2486570577556728 0.941479368642921 0.2461374514707439 0.0033537993821664 0.0021392900294222 0.0 0.0004095004095004 0.0733491569221699 0.0 222 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1104681 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0040057746789357 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0012814156885439 0.0018097844702233 0.0 0.0 0.0 0.0 8 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1104743 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0040035397123541 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0024635726452692 0.0009242223287825 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1104760 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.004003232435463 0.2490567623945399 0.7470475610360806 0.2461374514707439 0.011649387573427 0.0007714919761827 0.0 0.0 0.0 0.0 84 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1104848 C3 LRP1 C3-LRP1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0040004057380134 0.7796725988275006 0.6207977546603366 0.6198216015396206 0.000819605673545 0.0016667952436519 0.0 0.0 0.0 0.0 144 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1104891 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0039989205963528 0.6303642896310324 0.6331674633943454 0.9592803095773328 0.0014431743145616 0.0007400708115376 0.0 0.0001003344481605 0.0231224639554507 0.0 1495 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1104990 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.003995928429802 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.00146889578236 0.0007880862995141 0.0 0.0 0.0 0.0 1490 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1105000 VWF SELP VWF-SELP Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0039955995666388 0.6332974881236617 0.7760344326192508 0.909150863993142 0.0019871862905238 0.0004582650848664 0.0 5.783021050196623e-05 0.0290849091342 0.0 1572 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1105029 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0039947467618707 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0015409900107563 0.0009436211854823 0.0 0.000697350069735 0.0775707510369413 0.0 239 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1105035 VWF SELP VWF-SELP CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0039946272726139 0.9275752708651288 0.941479368642921 0.8875000050982297 0.000245041593909 0.0021392900294222 0.0 0.0 0.0 0.0 1424 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1105076 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated -> 11q13 Invasive Tumor Cells (G1/S) 0.0039935346993031 0.6301823358791634 0.6587114738285964 0.9161861017439124 0.00146889578236 0.0007261054236978 0.0 0.0005434782608695 0.0665501597556886 0.0 460 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1105125 MMRN2 CD93 MMRN2-CD93 Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0039920724161181 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0002165306714062 0.0053794918117879 0.0 0.0 0.0 0.0 126 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1105146 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0039913664506658 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0036991419150414 0.0028784826949613 0.0 0.0002010723860589 0.0520233326071717 0.0 373 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1105150 VWF ITGA9 VWF-ITGA9 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.00399121755914 0.6332974881236617 0.7831795333113832 0.6198216015396206 0.00023686843287 0.0055509879377996 0.0 0.0 0.0 0.0 137 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1105223 VWF SELP VWF-SELP CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.003989105649717 0.9275752708651288 0.4623922682986163 0.7204611100467462 0.000245041593909 0.0053213839468185 0.0 0.0 0.0 0.0 1884 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1105246 COL4A1 CD93 COL4A1-CD93 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0039884259114642 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.0002970267018348 0.0042738820064046 0.0 0.0 0.0 0.0 144 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1105319 VWF SELP VWF-SELP CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0039863554749327 0.9275752708651288 0.7760344326192508 0.6198216015396206 0.000245041593909 0.0036702914086929 0.0 3.412503412503413e-05 0.0142335471615075 0.0 1332 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1105366 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0039850512608819 0.4593282471594782 0.7763428264267787 0.2461374514707439 0.0181222899145132 0.0002517784065132 0.0 0.0 0.0 0.0 1384 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1105480 VWF SELP VWF-SELP Myoepithelial Cells B Cells Myoepithelial Cells -> B Cells 0.003981742647702 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0025256125075084 0.0004582650848664 0.0 0.0 0.0 0.0 394 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1105515 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes B Cells T Lymphocytes -> B Cells 0.0039805283442612 0.8630183004227985 0.8445107771175474 0.9318789094584046 0.0006856224272495 0.0008542071298387 0.0 5.227639958178879e-05 0.0096551614076245 0.0 5010 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1105544 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0039795819307855 0.2490567623945399 0.7746834992804791 0.2461374514707439 0.011649387573427 0.00071798405859 0.0 0.0 0.0 0.0 176 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1105558 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0039792369901659 0.662063103571249 0.2491073778594529 0.2461374514707439 0.0491302556793708 0.0001990509171164 0.0 0.0 0.0 0.0 5 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1105586 VWF SELP VWF-SELP Basal-like Structured DCIS Cells B Cells Basal-like Structured DCIS Cells -> B Cells 0.0039784412829737 0.6332974881236617 0.7760344326192508 0.8693461273411047 0.0020251995753771 0.0004582650848664 0.0 0.0 0.0 0.0 270 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1105785 VEGFC FLT1 VEGFC-FLT1 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0039720324220662 0.4636527906642655 0.878254460598671 0.7204611100467462 0.0023125636768155 0.0005788283879716 0.0 0.0 0.0 0.0 306 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1105786 C1QB LRP1 C1QB-LRP1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0039719900329268 0.7452691992612583 0.7769451595923457 1.0 0.0012199377895337 0.0005558995075445 0.0 0.0003312720848056 0.0417935970783034 0.0 1132 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1105847 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Endothelial Cells Macrophages -> Endothelial Cells 0.0039694040888983 0.6303682835571691 0.773263018678637 0.8875000050982297 0.0002750231449378 0.0032875740549697 0.0 8.533879501621436e-05 0.0137698399295454 0.0 2790 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1106009 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.003964547277814 0.9275752708651288 0.7346293219749174 0.7204611100467462 0.000245041593909 0.0032275631628407 0.0 0.0 0.0 0.0 285 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1106037 COL4A1 CD93 COL4A1-CD93 B Cells Plasma Cells B Cells -> Plasma Cells 0.0039635538191391 0.8684504425765611 0.4630027772793905 0.6198216015396206 0.0016831757123532 0.0009242223287825 0.0 0.0 0.0 0.0 297 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1106053 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0039629732101764 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.00146889578236 0.0009436211854823 0.0 0.0 0.0 0.0 253 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1106079 VWF SELP VWF-SELP CAFs, DCIS Associated CXCL14+ Fibroblasts CAFs, DCIS Associated -> CXCL14+ Fibroblasts 0.0039619623802528 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0071496754272206 0.0001189339410417 0.0 0.0 0.0 0.0 11475 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1106125 C1QB LRP1 C1QB-LRP1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0039603546703615 0.4601010570874773 0.7769451595923457 0.7204611100467462 0.0026949121497638 0.0005558995075445 0.0 0.0087209302325581 1.0 0.0 43 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1106126 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0039603487517072 0.2486570577556728 0.950463483645931 0.2461374514707439 0.0033537993821664 0.0019776346124415 0.0 6.568575932737782e-05 0.0275581813521961 0.0 1384 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1106215 MMRN2 CD93 MMRN2-CD93 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0039580131774003 0.8571898293845529 0.6587114738285964 0.6198216015396206 0.0004196880356983 0.0026174949623928 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1106226 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0039574595405122 0.6213271600240247 0.252518874138558 0.2461374514707439 0.0052560850129547 0.0018925243453249 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1106273 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts T Lymphocytes CXCL14+ Fibroblasts -> T Lymphocytes 0.0039560897267859 0.940547666092272 0.6347970925105053 0.6198216015396206 0.0001298888146421 0.0079745943515326 0.0 0.0 0.0 0.0 1881 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1106286 MMRN2 CD93 MMRN2-CD93 Macrophages Luminal-like Amorphous DCIS Cells Macrophages -> Luminal-like Amorphous DCIS Cells 0.0039556858413418 0.893316592628645 0.4630027772793905 0.2461374514707439 0.0007691101630988 0.0048929293424311 0.0 0.0 0.0 0.0 263 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1106331 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0039543390627899 0.6332974881236617 0.6207977546603366 0.9592803095773328 0.0003521782369754 0.0028784826949613 0.0 9.238728750923872e-05 0.0093637824420708 0.0 1476 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1106354 VWF SELP VWF-SELP Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0039535431559039 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0003457348439318 0.0032078747392388 0.0 0.0 0.0 0.0 271 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1106384 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0039527230659772 0.9275752708651288 0.2550748532138862 0.2461374514707439 0.000245041593909 0.0267255153180908 0.0 7.621486494725931e-05 0.0041678898670193 0.0 1491 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1106427 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0039514817345278 0.785133132759182 0.2491073778594529 0.2461374514707439 0.001039571291679 0.0076066460958003 0.0 0.0010245901639344 0.4324181729459365 0.0 122 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1106437 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0039512009464145 0.4629984640915818 0.6207977546603366 0.6198216015396206 0.0012814156885439 0.0016667952436519 0.0 0.0007495590828924 0.094830442446387 0.0 315 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1106447 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0039508858968703 0.6319926036888139 0.7346293219749174 0.6198216015396206 0.0004094805141934 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1106563 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0039468808101108 0.7160288858520609 0.4638256179742202 1.0 0.0012306151710811 0.0009249287638231 0.0 0.0 0.0 0.0 283 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1106606 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0039454330168184 0.6342079770588467 0.896164124004365 0.6198216015396206 0.002196330917593 0.0004874986369898 0.0 0.0 0.0 0.0 1490 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1106620 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) T Lymphocytes 11q13 Invasive Tumor Cells (G1/S) -> T Lymphocytes 0.0039449092809418 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0001959417442809 0.0063011237754475 0.0 0.0 0.0 0.0 69 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1106671 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells B Cells Dendritic Cells -> B Cells 0.0039435294602612 0.6301823358791634 0.6347970925105053 0.909150863993142 0.0015409900107563 0.000671064546954 0.0 0.0002120441051738 0.070327618695807 0.0 1572 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1106673 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0039434084442357 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0007263013575398 0.0016667952436519 0.0 0.0 0.0 0.0 42 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1106707 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Macrophages Mast Cells -> Macrophages 0.0039417880902378 0.8571898293845529 0.9195415044619336 0.8567148457705164 0.0004196880356983 0.0013235329769289 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1106748 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0039402675145592 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0003521782369754 0.0267255153180908 0.0 0.0 0.0 0.0 19 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1106780 C3 LRP1 C3-LRP1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0039391998806547 0.8509500867818902 0.6207977546603366 0.6198216015396206 0.0006305085967044 0.0018097844702233 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1106901 VWF SELP VWF-SELP B Cells Basal-like Structured DCIS Cells B Cells -> Basal-like Structured DCIS Cells 0.0039353629411919 0.6332974881236617 0.7760344326192508 0.8693461273411047 0.00023686843287 0.0036702914086929 0.0 0.0 0.0 0.0 360 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1106909 MMRN2 CD93 MMRN2-CD93 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0039349951062952 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0031934983073077 0.0003375370073613 0.0 0.0 0.0 0.0 1880 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1106947 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.0039334863683775 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.002196330917593 0.0009249287638231 0.0 0.0013175230566534 0.2327071351247858 0.0 253 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1106961 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0039330504118409 0.255669001367946 0.6631822525600675 0.2461374514707439 0.0002269856810233 0.0390724515618796 0.0 0.0 0.0 0.0 184 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1107025 MMP2 PECAM1 MMP2-PECAM1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0039309840068015 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0024819960935566 0.0004089864655001 0.0 0.0 0.0 0.0 800 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1107062 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Basal-like Structured DCIS Cells 0.0039298821939098 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.000393370777602 0.0030676679668133 0.0 3.192848020434227e-05 0.0208094616603435 0.0 1305 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1107071 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0039296072046071 0.940547666092272 0.7154802332407408 0.7204611100467462 0.0001298888146421 0.0058465532256424 0.0 0.0 0.0 0.0 1884 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107080 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0039293249586298 0.2451358214448441 0.773263018678637 0.2461374514707439 0.0010709508378277 0.0073658308476012 0.0 0.0047619047619047 0.8670214480312289 0.0 15 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1107083 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0039292695458214 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0001826541344284 0.0518891167572028 0.0 0.002734375 0.099834113823302 0.0 64 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1107097 MMRN2 CD93 MMRN2-CD93 Dendritic Cells 11q13 Invasive Tumor Cells (G1/S) Dendritic Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0039287562403277 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0015409900107563 0.0007261054236978 0.0 0.0 0.0 0.0 209 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107146 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0039271006249841 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0033537993821664 0.0028784826949613 0.0 0.0002437241043139 0.0247023107855167 0.0 373 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1107165 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0039265232275844 0.940547666092272 0.6347970925105053 0.6198216015396206 0.0001298888146421 0.0076236123034427 0.0 0.0 0.0 0.0 1422 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107184 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0039259103437833 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0061207051981986 0.0012252690191386 0.0 9.852863899106671e-05 0.079056610756631 0.0 1384 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1107188 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0039257806544127 0.6301823358791634 0.6347970925105053 0.909150863993142 0.0003083910058032 0.003263637675389 0.0 0.0 0.0 0.0 1549 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107199 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0039254733392139 0.7160288858520609 0.7470475610360806 0.7204611100467462 0.0012306151710811 0.0007714919761827 0.0 0.003875968992248 1.0 0.0 43 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1107263 VWF SELP VWF-SELP Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0039234026931103 0.7158082793127664 0.7478729882108823 0.7204611100467462 0.0003457348439318 0.0027351735586246 0.0 0.0 0.0 0.0 43 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1107286 VWF ITGA9 VWF-ITGA9 B Cells Plasma Cells B Cells -> Plasma Cells 0.0039226099517191 0.6332974881236617 0.7292496872084557 0.6198216015396206 0.00023686843287 0.0053724660607752 0.0 0.0 0.0 0.0 297 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1107295 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.003922316554583 0.250044481781731 0.7779918296243433 0.2461374514707439 0.0070431301838115 0.001079730675535 0.0 0.0 0.0 0.0 176 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107307 VWF SELP VWF-SELP CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0039220096573928 0.9275752708651288 0.7478729882108823 0.7827641335561659 0.000245041593909 0.0027351735586246 0.0 8.641548565502938e-05 0.0047432170038663 0.0 526 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1107351 MMRN2 CD93 MMRN2-CD93 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0039208452642411 0.8571898293845529 0.8347945881127203 1.0 0.0004196880356983 0.0012097093680331 0.0 0.0 0.0 0.0 14 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107368 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Plasma Cells T Lymphocytes -> Plasma Cells 0.0039203426898335 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0006856224272495 0.0021449819680126 0.0 0.0002337540906965 0.0084833909090053 0.0 713 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1107479 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0039167270916312 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0208904415011529 0.0004471667362236 0.0 0.0 0.0 0.0 179 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107602 VWF SELP VWF-SELP Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0039132799306073 0.7158082793127664 0.941479368642921 0.7204611100467462 0.0003457348439318 0.0021392900294222 0.0 0.0 0.0 0.0 337 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1107673 MMRN2 CD93 MMRN2-CD93 Macrophages B Cells Macrophages -> B Cells 0.0039107507465213 0.893316592628645 0.7779918296243433 0.6198216015396206 0.0007691101630988 0.001079730675535 0.0 0.0 0.0 0.0 1074 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107688 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0039101334352986 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0265972645862203 0.0003386430177035 0.0 0.0007564841498559 0.078409067573059 0.0 694 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1107717 VWF ITGA9 VWF-ITGA9 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0039093217973184 0.2486570577556728 0.863034163938375 0.2461374514707439 0.0001077515101466 0.0627102121186242 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1107728 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0039089382952623 0.8284725546778968 0.8537710813834968 1.0 0.0012187708721425 0.0004138063814779 0.0 0.0 0.0 0.0 14 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1107739 VWF SELP VWF-SELP B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0039085145066047 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.00023686843287 0.0045674276780054 0.0 0.0 0.0 0.0 50 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1107814 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Basal-like Structured DCIS Cells Plasma Cells -> Basal-like Structured DCIS Cells 0.0039054913402259 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0002165306714062 0.0057802287131517 0.0 0.0 0.0 0.0 126 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1107833 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0039049270209654 0.2451358214448441 0.773263018678637 0.2461374514707439 0.0010709508378277 0.0070956399217802 0.0 0.0 0.0 0.0 9 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1107979 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0038998375853154 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0009692519480124 0.0012252690191386 0.0 0.0 0.0 0.0 339 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1108012 VWF ITGA9 VWF-ITGA9 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0038984510525476 0.6332974881236617 0.6252253442669611 0.7917001487310438 0.00023686843287 0.0047273851759697 0.0 0.0 0.0 0.0 42 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1108027 VWF SELP VWF-SELP CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0038978835550707 0.9275752708651288 0.7760344326192508 0.6198216015396206 0.000245041593909 0.0032078747392388 0.0 0.0 0.0 0.0 887 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1108060 MMRN2 CD93 MMRN2-CD93 Plasma Cells Myoepithelial Cells Plasma Cells -> Myoepithelial Cells 0.0038967787369384 0.7205550478301406 0.4630027772793905 0.8293805866303694 0.0002165306714062 0.0058437228618857 0.0 0.0 0.0 0.0 324 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1108074 VWF LRP1 VWF-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0038962317882347 0.7848266128497919 0.6207977546603366 0.6198216015396206 0.0004024409845247 0.0028784826949613 0.0 0.0 0.0 0.0 30 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1108170 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0038926164307851 0.7468485855611411 0.6207977546603366 0.6198216015396206 0.0006689050756654 0.0018097844702233 0.0 0.0 0.0 0.0 32 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1108172 VWF SELP VWF-SELP Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0038925669399198 0.7848266128497919 0.4623922682986163 0.2461374514707439 0.0004024409845247 0.0096770075292062 0.0 0.0 0.0 0.0 122 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1108292 CD34 SELP CD34-SELP CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0038886175454747 0.9303167350027568 0.7760344326192508 0.6198216015396206 0.0016860250240652 0.0004582650848664 0.0 0.0 0.0 0.0 791 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1108379 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0038857577109359 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0083565457974945 0.0001189339410417 0.0 0.0 0.0 0.0 339 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1108380 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0038857527640156 0.7856500335676843 0.8347945881127203 0.7827641335561659 0.0005542667491398 0.0012097093680331 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1108385 DLL4 NOTCH3 DLL4-NOTCH3 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0038856687342488 0.6342079770588467 0.8818326005152037 0.6198216015396206 0.0002327631000826 0.0042655619249233 0.0 0.0 0.0 0.0 800 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1108389 C3 LRP1 C3-LRP1 Mast Cells B Cells Mast Cells -> B Cells 0.0038855331475344 0.8509500867818902 0.6207977546603366 0.6198216015396206 0.0006305085967044 0.0016667952436519 0.0 0.0008928571428571 0.1639913078619763 0.0 112 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1108390 C1QB LRP1 C1QB-LRP1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0038855141014894 0.7753420160918723 0.8755243548400705 1.0 0.0012213774841743 0.0004150165744076 0.0 0.0044642857142857 0.5525674258674745 0.0 14 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1108434 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Myeloid Cells Basal-like Structured DCIS Cells -> Myeloid Cells 0.0038840948062589 0.6332974881236617 0.7769451595923457 0.6198216015396206 0.0020251995753771 0.0005558995075445 0.0 0.0 0.0 0.0 129 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1108484 MMP2 PECAM1 MMP2-PECAM1 B Cells Mast Cells B Cells -> Mast Cells 0.0038827108436344 0.6303642896310324 0.8537710813834968 0.6198216015396206 0.0024819960935566 0.0004138063814779 0.0 0.0002577319587628 0.037519770032671 0.0 97 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1108546 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.003880395805574 0.8630183004227985 0.7426180951053148 0.6198216015396206 0.0016575843792215 0.0005184623914895 0.0 0.0 0.0 0.0 161 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1108588 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0038789522624705 0.2486570577556728 0.2531744428854943 0.3990376746076917 0.0033537993821664 0.0040430820937484 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1108591 CCN1 CAV1 CCN1-CAV1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0038788529653238 0.8749036366850302 0.8617632615906476 1.0 0.0004337320404416 0.0010414441948928 0.0 0.0 0.0 0.0 14 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1108594 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0038786674289116 0.6301823358791634 0.9195415044619336 0.6198216015396206 0.000716220684292 0.0013235329769289 0.0 0.0 0.0 0.0 119 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1108605 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0038780572819487 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0003521782369754 0.0053213839468185 0.0 0.0 0.0 0.0 453 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1108620 COL4A1 CD93 COL4A1-CD93 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0038776320775071 0.4604235282221027 0.4630027772793905 1.0 0.0017253404164066 0.0009242223287825 0.0 0.0002523977788995 0.0486872226197616 0.0 283 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1108641 VWF SELP VWF-SELP B Cells Dendritic Cells B Cells -> Dendritic Cells 0.0038768425889542 0.6332974881236617 0.7760344326192508 0.909150863993142 0.00023686843287 0.0032078747392388 0.0 0.0 0.0 0.0 1549 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1108702 VWF SELP VWF-SELP Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.003874879993255 0.9011206516381156 0.6572093097629401 0.6198216015396206 0.0008850282134344 0.0010419094417808 0.0 0.0 0.0 0.0 129 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1108730 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Macrophages B Cells -> Macrophages 0.0038737777887339 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0001109003117737 0.0073658308476012 0.0 2.23563603845294e-05 0.0040705232301935 0.0 1065 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1108751 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0038731894349483 0.7856500335676843 0.7461459456652184 1.0 0.0005542667491398 0.0010390313650636 0.0 0.0004416961130742 0.0512926789991893 0.0 1132 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1108789 VWF LRP1 VWF-LRP1 Dendritic Cells Myeloid Cells Dendritic Cells -> Myeloid Cells 0.0038718478964917 0.6332974881236617 0.7769451595923457 0.6198216015396206 0.0019871862905238 0.0005558995075445 0.0 0.0 0.0 0.0 161 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1108824 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0038708160460924 0.2490567623945399 0.7754072541855492 0.2461374514707439 0.011649387573427 0.0006074333625108 0.0 0.0 0.0 0.0 176 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1108836 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0038702260169375 0.250044481781731 0.7461459456652184 0.2461374514707439 0.0070431301838115 0.0010390313650636 0.0 0.0 0.0 0.0 84 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1108896 VWF ITGA9 VWF-ITGA9 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.003868486740466 0.7158082793127664 0.950463483645931 0.7204611100467462 0.0003457348439318 0.0019776346124415 0.0 0.0002970885323826 0.1246422319981682 0.0 306 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1108956 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0038666513462815 0.893316592628645 0.7154802332407408 0.7204611100467462 0.0007691101630988 0.0009436211854823 0.0 0.0 0.0 0.0 326 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1108981 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.003865843557004 0.6303642896310324 0.7841656220878274 0.6198216015396206 0.0008320501336843 0.001309307002134 0.0 0.0 0.0 0.0 21 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1108983 VWF SELP VWF-SELP Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0038658021743795 0.8525936146535493 0.6572093097629401 0.6198216015396206 0.0002103933337194 0.0045674276780054 0.0 0.0 0.0 0.0 10 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1109082 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Endothelial Cells CXCL14+ Fibroblasts -> Endothelial Cells 0.0038622332655116 0.6303682835571691 0.773263018678637 0.9429656149619918 0.000219642761279 0.0032875740549697 0.0 8.785802143735723e-06 0.0014176329669163 0.0 2710 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1109229 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0038568352883298 0.8284725546778968 0.930308383061206 0.8567148457705164 0.0012187708721425 0.0004089864655001 0.0 0.0 0.0 0.0 148 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1109243 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.003856338205585 0.633566764858408 0.7760344326192508 0.7917001487310438 0.0018436902762588 0.0004582650848664 0.0 0.0 0.0 0.0 38 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1109252 VWF ITGA9 VWF-ITGA9 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.003855848693969 0.8525936146535493 0.6252253442669611 0.6198216015396206 0.0002103933337194 0.0047273851759697 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1109272 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0038551281493588 0.8498991475190484 0.2550748532138862 0.2461374514707439 0.018166235813628 0.0003386430177035 0.0 0.0003602305475504 0.0223745681708343 0.0 694 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1109298 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0038541825638153 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.0003521782369754 0.0032275631628407 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1109309 A2M LRP1 A2M-LRP1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0038535920681998 0.7460047258226694 0.7769451595923457 1.0 0.0010163752993685 0.0005558995075445 0.0 0.0001104240282685 0.0208839473690531 0.0 1132 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1109371 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0038512615902903 0.6301823358791634 0.6347970925105053 1.0 0.000716220684292 0.0011388334136451 0.0 0.0001805706031058 0.024040653574182 0.0 1846 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1109401 MMRN2 CD93 MMRN2-CD93 B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0038505294457002 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0003083910058032 0.0058437228618857 0.0 0.0 0.0 0.0 496 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1109426 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.003849735035765 0.6342079770588467 0.8341464445360613 0.6198216015396206 0.0053032910137447 0.0001871866311057 0.0 0.0 0.0 0.0 18 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1109427 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Pericytes B Cells -> Pericytes 0.003849724754177 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0001109003117737 0.0070956399217802 0.0 0.0001376273052573 0.0172727144626456 0.0 1211 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1109435 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0038494843170594 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0078992851324392 0.0001189339410417 0.0 0.0 0.0 0.0 1109 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1109479 C1QB LRP1 C1QB-LRP1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0038479169726338 0.4601010570874773 0.8755243548400705 0.7204611100467462 0.0026949121497638 0.0004150165744076 0.0 0.0 0.0 0.0 48 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1109481 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0038478777642729 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0002269856810233 0.0293031867940321 0.0 0.0 0.0 0.0 9 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1109486 A2M LRP1 A2M-LRP1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0038478237229749 0.7741139100414175 0.7769451595923457 0.6198216015396206 0.0015661096645571 0.0005558995075445 0.0 0.0 0.0 0.0 137 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1109525 THBS2 CD36 THBS2-CD36 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0038464126463943 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0008527942416386 0.0096442330625583 0.0 0.0 0.0 0.0 211 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1109560 THBS2 CD36 THBS2-CD36 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0038453732898882 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0008527942416386 0.0011409783203169 0.0 0.0 0.0 0.0 800 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1109565 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0038450160996779 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0020251995753771 0.0040430820937484 0.0 0.0002619858527639 0.7034180289623805 0.0 694 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1109670 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0038412922042214 0.4629984640915818 0.2550748532138862 0.3990376746076917 0.0201301851612071 0.0003386430177035 0.0 0.0 0.0 0.0 97 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1109672 CD34 SELP CD34-SELP Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0038411720106634 0.8963354148873306 0.8819126042133903 0.8875000050982297 0.0038492365148421 0.0001189339410417 0.0 0.0 0.0 0.0 1462 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1109708 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0038395843396347 0.7468485855611411 0.6207977546603366 0.6198216015396206 0.0006689050756654 0.0016667952436519 0.0 0.0001929012345679 0.0244048932766437 0.0 144 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1109727 C1QB LRP1 C1QB-LRP1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0038390935739042 0.7753420160918723 0.7769451595923457 0.7827641335561659 0.0012213774841743 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1109832 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0038356083742352 0.255669001367946 0.4596166826058663 0.2461374514707439 0.0002269856810233 0.0484993884807927 0.0 0.0181818181818181 0.2584814586547753 0.0 15 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1109854 VWF SELP VWF-SELP Mast Cells Myoepithelial Cells Mast Cells -> Myoepithelial Cells 0.0038347778052482 0.8525936146535493 0.4623922682986163 0.7204611100467462 0.0002103933337194 0.0053213839468185 0.0 0.0 0.0 0.0 66 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1109903 VWF ITGA9 VWF-ITGA9 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.003832892408683 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0019871862905238 0.0040430820937484 0.0 0.0 0.0 0.0 75 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1109904 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0038327699575502 0.718867305289982 0.2491073778594529 0.2461374514707439 0.0361307801045652 0.0001990509171164 0.0 0.0004289799809342 0.2878670304638417 0.0 1049 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1109910 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0038326130106278 0.940547666092272 0.7779918296243433 0.6198216015396206 0.0001298888146421 0.0053794918117879 0.0 0.0 0.0 0.0 1332 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1109918 A2M LRP1 A2M-LRP1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0038323982794521 0.4648000335061383 0.7769451595923457 0.7204611100467462 0.0021905373114471 0.0005558995075445 0.0 0.0 0.0 0.0 43 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1109929 VWF SELP VWF-SELP Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0038321340273818 0.8525936146535493 0.7760344326192508 0.6198216015396206 0.0002103933337194 0.0036702914086929 0.0 0.0 0.0 0.0 30 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1109938 CCN1 CAV1 CCN1-CAV1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.003831928903027 0.8749036366850302 0.7832252605020791 0.7827641335561659 0.0004337320404416 0.00136079311934 0.0 0.0 0.0 0.0 23 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1109972 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Myoepithelial Cells 11q13 Invasive Tumor Cells (G1/S) -> Myoepithelial Cells 0.0038307079254388 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0001959417442809 0.0056518532344078 0.0 0.0 0.0 0.0 453 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1110049 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0038281507468642 0.2491408586098361 0.7841656220878274 0.2461374514707439 0.0049987108499989 0.001309307002134 0.0 0.0 0.0 0.0 84 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1110123 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0038253987825211 0.250044481781731 0.6347970925105053 0.2461374514707439 0.0070431301838115 0.0011388334136451 0.0 0.0 0.0 0.0 26 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1110143 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0038247747253834 0.6160088550075702 0.6632137581773894 1.0 0.0001971810371238 0.0038860320327025 0.0 2.462326405988378e-05 0.013928867092567 0.0 1846 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1110158 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0038244816595508 0.255669001367946 0.8622452992050237 0.2461374514707439 0.0002269856810233 0.0254056950469408 0.0 0.0002658160552897 0.041767825431708 0.0 684 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1110192 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Endothelial Cells Plasma Cells -> Endothelial Cells 0.0038233653100167 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0002705513462707 0.0032875740549697 0.0 8.884150675195451e-05 0.0143350199266536 0.0 536 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1110200 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.0038230012023567 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.00146889578236 0.000671064546954 0.0 0.0 0.0 0.0 917 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1110213 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0038225945433238 0.2490567623945399 0.896164124004365 0.2461374514707439 0.011649387573427 0.0004874986369898 0.0 0.0 0.0 0.0 1384 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1110277 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0038198964817559 0.7840818683779507 0.8341464445360613 0.7827641335561659 0.0032417203409647 0.0001871866311057 0.0 0.0 0.0 0.0 23 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1110308 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0038186442111441 0.2490567623945399 0.6580560501976399 0.2461374514707439 0.000126812416921 0.0606066271159369 0.0 0.0 0.0 0.0 2 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1110323 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0038181670314144 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0002269856810233 0.0279580382843415 0.0 0.0 0.0 0.0 15 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1110337 VWF SELP VWF-SELP Mast Cells Macrophages Mast Cells -> Macrophages 0.003817557473368 0.8525936146535493 0.941479368642921 0.8567148457705164 0.0002103933337194 0.0021392900294222 0.0 0.0 0.0 0.0 165 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1110423 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0038141187577035 0.893316592628645 0.6347970925105053 0.6198216015396206 0.0007691101630988 0.0011388334136451 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1110454 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0038134973011318 0.250044481781731 0.9003264838243337 0.2461374514707439 0.0070431301838115 0.0007880862995141 0.0 0.0001204238921001 0.0804139444203395 0.0 1384 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1110502 VWF LRP1 VWF-LRP1 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0038111695311696 0.8525936146535493 0.7346293219749174 0.7204611100467462 0.0002103933337194 0.0032275631628407 0.0 0.0 0.0 0.0 50 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1110505 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0038110198459594 0.2490567623945399 0.4638256179742202 0.2461374514707439 0.011649387573427 0.0009249287638231 0.0 0.0 0.0 0.0 272 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1110596 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Macrophages Mast Cells -> Macrophages 0.0038073856090411 0.6303682835571691 0.773263018678637 0.8567148457705164 9.902323108165852e-05 0.0073658308476012 0.0 0.0004329004329004 0.0788201316392026 0.0 165 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1110625 VEGFC FLT1 VEGFC-FLT1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0038063294104297 0.7745997874735252 0.878254460598671 0.6198216015396206 0.0012459853895406 0.0005788283879716 0.0 0.0 0.0 0.0 800 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1110644 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells B Cells Plasma Cells -> B Cells 0.0038056429212916 0.7160288858520609 0.7746834992804791 0.6198216015396206 0.0012306151710811 0.00071798405859 0.0 0.0 0.0 0.0 315 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1110667 CD34 SELP CD34-SELP Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0038047997530527 0.8532069650852002 0.6572093097629401 0.6198216015396206 0.00083777361258 0.0010419094417808 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1110731 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0038023940717782 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.000716220684292 0.0109188419829382 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1110755 A2M LRP1 A2M-LRP1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0038015934977321 0.8392912392980421 0.6207977546603366 0.6198216015396206 0.0005164482812395 0.0018097844702233 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1110796 CCN1 CAV1 CCN1-CAV1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0038001157697089 0.2542249848376565 0.943345641464811 0.2461374514707439 0.0014656941948563 0.0034806998160403 0.0 0.0 0.0 0.0 20 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1110809 VWF LRP1 VWF-LRP1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0037998027665116 0.8525936146535493 0.2550748532138862 0.2461374514707439 0.0002103933337194 0.0267255153180908 0.0 0.0 0.0 0.0 41 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1110845 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.003798774180735 0.6659645551150886 0.7763428264267787 0.6198216015396206 0.0037243679732516 0.0002517784065132 0.0 0.0 0.0 0.0 380 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1110859 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0037980650488341 0.6301823358791634 0.7779918296243433 0.7917001487310438 0.000716220684292 0.001079730675535 0.0 0.006578947368421 0.7226140486770763 0.0 38 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1110929 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.003795559620777 0.7205550478301406 0.2491545808994955 0.2461374514707439 0.0151307911035231 0.0004471667362236 0.0 0.0003177629488401 0.0385532034207206 0.0 1049 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1110966 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0037946749985248 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0172764782878141 0.0004471667362236 0.0 0.0 0.0 0.0 694 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1110967 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.003794577059009 0.6242573126045354 0.8765901449012573 0.6198216015396206 0.0020491452254277 0.0004295051170816 0.0 0.0 0.0 0.0 18 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1110969 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0037944313952312 0.6160088550075702 0.6631822525600675 0.9592803095773328 0.0001971810371238 0.0038621268649178 0.0 3.0795762503079576e-05 0.0190354264485597 0.0 1476 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1111208 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0037853962931444 0.6301823358791634 0.8514619504364779 0.6198216015396206 0.0015409900107563 0.0005740632036187 0.0 0.0 0.0 0.0 151 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1111241 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Pericytes Mast Cells -> Pericytes 0.0037837448163523 0.6303682835571691 0.773263018678637 0.8567148457705164 9.902323108165852e-05 0.0070956399217802 0.0 0.0002927400468384 0.0367399131398076 0.0 244 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1111254 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0037833632071332 0.8284725546778968 0.6331674633943454 0.6198216015396206 0.0012187708721425 0.0007400708115376 0.0 0.0 0.0 0.0 1 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1111289 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0037820466274503 0.250044481781731 0.7154802332407408 0.2461374514707439 0.0070431301838115 0.0009436211854823 0.0 0.0006127450980392 0.0681595937420182 0.0 272 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1111345 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0037797513570762 0.7856500335676843 0.2491545808994955 0.2461374514707439 0.0005542667491398 0.0109188419829382 0.0 0.0 0.0 0.0 122 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1111393 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0037779471276898 0.6319926036888139 0.6207977546603366 1.0 0.0004094805141934 0.0018097844702233 0.0 0.0001625135427952 0.0573884099758447 0.0 1846 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1111470 COL4A2 CD93 COL4A2-CD93 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0037751809517495 0.8355319038299565 0.4630027772793905 0.7204611100467462 0.001123788079051 0.0009242223287825 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1111514 VWF ITGA9 VWF-ITGA9 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0037738599662098 0.8525936146535493 0.950463483645931 0.8567148457705164 0.0002103933337194 0.0019776346124415 0.0 0.0 0.0 0.0 148 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1111517 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Mast Cells Basal-like Structured DCIS Cells -> Mast Cells 0.0037738221882431 0.6332974881236617 0.8755243548400705 0.6198216015396206 0.0020251995753771 0.0004150165744076 0.0 0.0 0.0 0.0 18 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1111537 VWF SELP VWF-SELP CAFs, Invasive Associated B Cells CAFs, Invasive Associated -> B Cells 0.003772714526735 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0016171311116606 0.0004582650848664 0.0 0.0 0.0 0.0 917 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1111567 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Mast Cells Macrophages -> Mast Cells 0.0037713317529329 0.893316592628645 0.8514619504364779 0.8567148457705164 0.0007691101630988 0.0005740632036187 0.0 0.0 0.0 0.0 165 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1111571 CD34 SELP CD34-SELP Plasma Cells B Cells Plasma Cells -> B Cells 0.0037712581988025 0.7168245244832976 0.7760344326192508 0.6198216015396206 0.0018206581062216 0.0004582650848664 0.0 0.0 0.0 0.0 315 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1111593 VWF SELP VWF-SELP Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0037702775776836 0.8525936146535493 0.7478729882108823 0.7827641335561659 0.0002103933337194 0.0027351735586246 0.0 0.0 0.0 0.0 23 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1111643 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0037684322421025 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0024635726452692 0.0003375370073613 0.0 0.0 0.0 0.0 339 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1111648 THBS2 CD36 THBS2-CD36 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0037682443441728 0.7809827257946271 0.8587566561291643 0.7827641335561659 0.0004779710276932 0.0011409783203169 0.0 0.0 0.0 0.0 527 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1111660 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0037675913617341 0.7463064942968751 0.4630027772793905 0.7204611100467462 0.0012430446376512 0.0009242223287825 0.0 0.0 0.0 0.0 37 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1111707 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0037655311870518 0.2486570577556728 0.6572093097629401 0.2461374514707439 0.0033537993821664 0.002113171886167 0.0 0.0006184291898577 0.1238070389886713 0.0 147 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1111788 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0037627135089698 0.6332974881236617 0.6572093097629401 0.9161861017439124 0.0003521782369754 0.002113171886167 0.0 0.0 0.0 0.0 408 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1111810 CCN1 CAV1 CCN1-CAV1 Mast Cells B Cells Mast Cells -> B Cells 0.0037620084743711 0.8749036366850302 0.62431395375366 0.6198216015396206 0.0004337320404416 0.0019304335593669 0.0 0.0 0.0 0.0 112 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1111814 VWF LRP1 VWF-LRP1 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0037619229782284 0.6332974881236617 0.8755243548400705 0.6198216015396206 0.0019871862905238 0.0004150165744076 0.0 0.0001505117399157 0.0184152039197375 0.0 151 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1111849 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0037604857219061 0.6332974881236617 0.7478729882108823 0.6198216015396206 0.0003521782369754 0.0027351735586246 0.0 0.0 0.0 0.0 21 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1111870 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0037598889876189 0.6301823358791634 0.8347945881127203 0.6198216015396206 0.000716220684292 0.0012097093680331 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1111871 THBS2 CD36 THBS2-CD36 Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0037598576955517 0.8581959463413404 0.6176321640000088 0.6198216015396206 0.0002636300075004 0.0032616151102094 0.0 0.0011574074074074 0.3665482217726896 0.0 144 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1111955 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0037565364797251 0.4601010570874773 0.2550748532138862 0.3990376746076917 0.0177188549930425 0.0003386430177035 0.0 0.0 0.0 0.0 97 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1111988 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0037552878802778 0.6301823358791634 0.8514619504364779 0.6198216015396206 0.00146889578236 0.0005740632036187 0.0 0.0 0.0 0.0 130 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1112104 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Macrophages 11q13 Invasive Tumor Cells (G1/S) -> Macrophages 0.0037507833011156 0.6332974881236617 0.941479368642921 0.6198216015396206 0.0003521782369754 0.0021392900294222 0.0 0.0 0.0 0.0 119 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1112109 COL4A2 CD93 COL4A2-CD93 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0037506207901232 0.8355319038299565 0.6587114738285964 0.6198216015396206 0.001123788079051 0.0007261054236978 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1112124 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0037501202451139 0.8560892486218385 0.2491073778594529 0.2461374514707439 0.0006966068981631 0.0076066460958003 0.0 0.0 0.0 0.0 41 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1112128 A2M LRP1 A2M-LRP1 Mast Cells B Cells Mast Cells -> B Cells 0.0037498014816233 0.8392912392980421 0.6207977546603366 0.6198216015396206 0.0005164482812395 0.0016667952436519 0.0 0.0 0.0 0.0 112 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1112137 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Basal-like Structured DCIS Cells CXCL14+ Fibroblasts -> Basal-like Structured DCIS Cells 0.0037494903306385 0.940547666092272 0.6347970925105053 0.6198216015396206 0.0001298888146421 0.0057802287131517 0.0 0.0 0.0 0.0 1332 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1112152 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0037490620035323 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0015572459193676 0.0004582650848664 0.0 0.0 0.0 0.0 42 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1112165 VEGFC FLT1 VEGFC-FLT1 Mast Cells B Cells Mast Cells -> B Cells 0.0037484775264517 0.8317042416754105 0.777821334064334 0.6198216015396206 0.0005440770361181 0.001271575589586 0.0 0.0 0.0 0.0 112 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1112171 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0037483441714537 0.7160288858520609 0.896164124004365 0.7204611100467462 0.0012306151710811 0.0004874986369898 0.0 0.0 0.0 0.0 306 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1112207 VWF SELP VWF-SELP Mast Cells Dendritic Cells Mast Cells -> Dendritic Cells 0.0037470848498303 0.8525936146535493 0.7760344326192508 0.6198216015396206 0.0002103933337194 0.0032078747392388 0.0 0.0002805836139169 0.0465593048896953 0.0 162 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1112274 C3 LRP1 C3-LRP1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0037452961844021 0.7796725988275006 0.7769451595923457 1.0 0.000819605673545 0.0005558995075445 0.0 0.0001325088339222 0.0297063915606443 0.0 1132 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1112336 COL4A1 CD93 COL4A1-CD93 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0037430805756371 0.7463064942968751 0.6587114738285964 0.6198216015396206 0.0012430446376512 0.0007261054236978 0.0 0.0 0.0 0.0 32 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1112349 THBS2 CD36 THBS2-CD36 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0037426604244146 0.8581959463413404 0.6176321640000088 0.6198216015396206 0.0002636300075004 0.0031731220372828 0.0 0.0 0.0 0.0 10 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1112386 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Myeloid Cells CAFs, Invasive Associated -> Myeloid Cells 0.0037411301144685 0.6332974881236617 0.7769451595923457 0.6198216015396206 0.0016171311116606 0.0005558995075445 0.0 0.0 0.0 0.0 143 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1112392 VWF LRP1 VWF-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0037410117399659 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0003457348439318 0.0028784826949613 0.0 0.0 0.0 0.0 3 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1112457 A2M LRP1 A2M-LRP1 B Cells Mast Cells B Cells -> Mast Cells 0.0037385808705832 0.7741139100414175 0.8755243548400705 0.6198216015396206 0.0015661096645571 0.0004150165744076 0.0 0.0 0.0 0.0 97 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1112486 VWF SELP VWF-SELP Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0037374928937277 0.7158082793127664 0.4623922682986163 0.2461374514707439 0.0003457348439318 0.0096770075292062 0.0 0.0 0.0 0.0 271 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1112503 MMRN2 CD93 MMRN2-CD93 Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0037367899877943 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0002165306714062 0.0042738820064046 0.0 0.0 0.0 0.0 285 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1112504 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0037366728164217 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0002165306714062 0.0044340558155446 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1112518 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells T Lymphocytes Mast Cells -> T Lymphocytes 0.0037362175769621 0.6303682835571691 0.8445107771175474 0.6198216015396206 9.902323108165852e-05 0.0083242517891534 0.0 0.0002776620852422 0.0324826410640132 0.0 343 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1112523 VWF SELP VWF-SELP Myeloid Cells CAFs, Invasive Associated Myeloid Cells -> CAFs, Invasive Associated 0.0037359323612033 0.7848266128497919 0.6572093097629401 0.6198216015396206 0.0004024409845247 0.002113171886167 0.0 0.0 0.0 0.0 160 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1112600 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0037332203663137 0.8624864526942296 0.8341464445360613 1.0 0.0020100505037262 0.0001871866311057 0.0 0.0 0.0 0.0 14 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1112651 HSPG2 LRP1 HSPG2-LRP1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0037312714756173 0.7789175740361626 0.7769451595923457 0.6198216015396206 0.0012941512528773 0.0005558995075445 0.0 0.0 0.0 0.0 137 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1112663 COL4A1 CD93 COL4A1-CD93 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.003730794516478 0.8684504425765611 0.8817184225858201 0.6198216015396206 0.0016831757123532 0.0003375370073613 0.0 0.0 0.0 0.0 800 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1112664 VWF LRP1 VWF-LRP1 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0037307406659737 0.9011206516381156 0.7769451595923457 0.7827641335561659 0.0008850282134344 0.0005558995075445 0.0 0.0 0.0 0.0 179 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1112698 EFNB2 PECAM1 EFNB2-PECAM1 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.003729304616569 0.7800321422220979 0.930308383061206 0.6198216015396206 0.0014623066995027 0.0004089864655001 0.0 0.0 0.0 0.0 800 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1112852 A2M LRP1 A2M-LRP1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0037235933679774 0.4648000335061383 0.8755243548400705 0.7204611100467462 0.0021905373114471 0.0004150165744076 0.0 0.0 0.0 0.0 48 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1112872 C1QB LRP1 C1QB-LRP1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0037229438860928 0.7753420160918723 0.2550748532138862 0.2461374514707439 0.0161519521398178 0.0003386430177035 0.0 0.0 0.0 0.0 33 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1112876 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.003722889124191 0.2490567623945399 0.4641352222874551 0.3990376746076917 0.000126812416921 0.0455121851821151 0.0 0.0 0.0 0.0 89 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1112907 THBS2 CD36 THBS2-CD36 Mast Cells Basal-like Structured DCIS Cells Mast Cells -> Basal-like Structured DCIS Cells 0.0037216371542034 0.8581959463413404 0.6176321640000088 0.6198216015396206 0.0002636300075004 0.0030676679668133 0.0 0.0 0.0 0.0 30 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1112935 MMRN2 CD93 MMRN2-CD93 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0037206679776878 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0003083910058032 0.0026174949623928 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1113015 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0037176756054644 0.6332974881236617 0.7769451595923457 0.6198216015396206 0.0015572459193676 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1113110 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0037135649004349 0.2491408586098361 0.7167436199046466 0.2461374514707439 0.0001826541344284 0.0326667674102811 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1113256 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0037078501216435 0.6332974881236617 0.950463483645931 0.6198216015396206 0.0003521782369754 0.0019776346124415 0.0 0.0002392344497607 0.1003697973458933 0.0 380 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1113269 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0037070512085461 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0001971810371238 0.0044430418127202 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1113298 CD34 SELP CD34-SELP B Cells Plasma Cells B Cells -> Plasma Cells 0.0037060008124234 0.633566764858408 0.4623922682986163 0.6198216015396206 0.0006336851232098 0.0022515473538965 0.0 0.0 0.0 0.0 297 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1113333 C1QB LRP1 C1QB-LRP1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0037048581238863 0.7452691992612583 0.8755243548400705 0.7827641335561659 0.0012199377895337 0.0004150165744076 0.0 0.0 0.0 0.0 23 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1113367 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0037034898061554 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0016171311116606 0.0040430820937484 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1113391 VWF SELP VWF-SELP Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0037026074546882 0.7158082793127664 0.4623922682986163 1.0 0.0003457348439318 0.0022515473538965 0.0 0.0003212335367812 0.0309985131177337 0.0 283 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1113399 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Plasma Cells Dendritic Cells -> Plasma Cells 0.0037024004641642 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0015409900107563 0.0009242223287825 0.0 0.0 0.0 0.0 239 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1113422 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells B Cells Plasma Cells -> B Cells 0.0037016309606486 0.7160288858520609 0.7754072541855492 0.6198216015396206 0.0012306151710811 0.0006074333625108 0.0 0.0 0.0 0.0 315 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1113601 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0036943011072165 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0036991419150414 0.0018097844702233 0.0 0.0 0.0 0.0 26 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1113676 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0036917013362961 0.255669001367946 0.6631822525600675 0.2461374514707439 0.0002269856810233 0.0267210109213584 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1113762 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0036883442435083 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.000245041593909 0.0028784826949613 0.0 0.0002039627039627 0.0206723504682642 0.0 390 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1113768 VWF LRP1 VWF-LRP1 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.00368822567913 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.00023686843287 0.0267255153180908 0.0 0.0006462731581214 0.0353421258297203 0.0 211 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1113772 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.003688148379214 0.6301823358791634 0.4630027772793905 0.2461374514707439 0.000716220684292 0.0048929293424311 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1113841 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.003685476707412 0.6332974881236617 0.6207977546603366 1.0 0.0003521782369754 0.0018097844702233 0.0 8.61814242095932e-05 0.0089529048537754 0.0 1846 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1113855 VWF SELP VWF-SELP CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0036848749370296 0.9275752708651288 0.4623922682986163 0.2461374514707439 0.000245041593909 0.0096770075292062 0.0 0.0 0.0 0.0 1491 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1113868 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0036845264332706 0.6342079770588467 0.7746834992804791 0.7917001487310438 0.000895875398841 0.00071798405859 0.0 0.0 0.0 0.0 38 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1113896 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Mast Cells B Cells -> Mast Cells 0.003683508111179 0.7800321422220979 0.8537710813834968 0.6198216015396206 0.0014623066995027 0.0004138063814779 0.0 0.0 0.0 0.0 97 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1113914 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.003682613739844 0.2491408586098361 0.9015117569158254 0.2461374514707439 0.0001826541344284 0.0246995741084876 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1113941 CD34 SELP CD34-SELP Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0036813140706846 0.7871981482311898 0.8819126042133903 0.7827641335561659 0.0038506427265089 0.0001189339410417 0.0 0.0 0.0 0.0 527 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1113963 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.003680390656897 0.2490567623945399 0.4638256179742202 0.2461374514707439 0.000126812416921 0.0689186266365139 0.0 0.0 0.0 0.0 89 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1113970 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0036802712779709 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0015572459193676 0.0040430820937484 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1113992 VWF LRP1 VWF-LRP1 Macrophages Mast Cells Macrophages -> Mast Cells 0.0036797719260552 0.9011206516381156 0.8755243548400705 0.8567148457705164 0.0008850282134344 0.0004150165744076 0.0 0.0 0.0 0.0 165 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114004 THBS2 CD36 THBS2-CD36 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.003679165849712 0.2510234128936706 0.8587566561291643 0.2461374514707439 5.260070730345377e-05 0.088850508457521 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114043 VWF LRP1 VWF-LRP1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0036776715435966 0.2486570577556728 0.8604147465201248 0.2461374514707439 0.0001077515101466 0.0436001007095475 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114089 COL4A1 CD93 COL4A1-CD93 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0036754641466284 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.0002970267018348 0.0026174949623928 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1114128 DLL4 NOTCH4 DLL4-NOTCH4 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0036739981763136 0.6342079770588467 0.6571792026963191 0.7917001487310438 0.0002327631000826 0.0032020139126304 0.0 0.0 0.0 0.0 42 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1114139 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.003673589948332 0.6303642896310324 0.6331674633943454 1.0 0.0008320501336843 0.0007400708115376 0.0 2.708559046587216e-05 0.0062419797062836 0.0 1846 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114153 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.003673263410373 0.6332974881236617 0.4623922682986163 0.2461374514707439 0.0003521782369754 0.0096770075292062 0.0 0.0 0.0 0.0 19 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1114155 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0036731763024239 0.6301823358791634 0.7830372268649692 0.6198216015396206 0.0003083910058032 0.0026038611777234 0.0 0.0 0.0 0.0 137 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1114164 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Plasma Cells CAFs, Invasive Associated -> Plasma Cells 0.003672952186325 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.00146889578236 0.0009242223287825 0.0 0.0 0.0 0.0 253 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1114176 A2M LRP1 A2M-LRP1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0036724311678842 0.7741139100414175 0.2550748532138862 0.2461374514707439 0.0149044683666724 0.0003386430177035 0.0 0.0 0.0 0.0 86 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1114221 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0036707156072222 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0008320501336843 0.0076066460958003 0.0 0.0 0.0 0.0 19 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114249 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0036695790859607 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0006856224272495 0.0008609682710384 0.0 0.0 0.0 0.0 1880 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1114260 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0036690472397379 0.6160088550075702 0.4600037439857229 0.2461374514707439 0.0001971810371238 0.017738069381683 0.0 0.0 0.0 0.0 19 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1114331 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0036668785884801 0.785133132759182 0.930308383061206 0.7827641335561659 0.001039571291679 0.0004089864655001 0.0 0.0001423149905123 0.2585040308122926 0.0 527 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114350 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.0036661859813266 0.7856500335676843 0.4630027772793905 0.2461374514707439 0.0005542667491398 0.0048929293424311 0.0 0.0 0.0 0.0 122 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1114368 THBS2 CD36 THBS2-CD36 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0036654124584791 0.8581959463413404 0.7763054211764489 0.7827641335561659 0.0002636300075004 0.0017638974017382 0.0 0.0 0.0 0.0 23 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114404 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0036637655413862 0.7856500335676843 0.9003264838243337 0.7827641335561659 0.0005542667491398 0.0007880862995141 0.0 0.0003162555344718 0.2111819716845349 0.0 527 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1114469 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0036613360364787 0.8571898293845529 0.2491545808994955 0.2461374514707439 0.0004196880356983 0.0109188419829382 0.0 0.0 0.0 0.0 41 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1114507 VWF LRP1 VWF-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0036601242157808 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0001077515101466 0.0587195251380622 0.0 0.0001235177865612 0.0128454517431049 0.0 184 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114538 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0036589379324154 0.7753420160918723 0.7769451595923457 0.7827641335561659 0.0009153913192522 0.0005558995075445 0.0 0.0 0.0 0.0 526 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1114554 MMP2 PECAM1 MMP2-PECAM1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0036583065935807 0.9067635403815892 0.2491073778594529 0.2461374514707439 0.0216588811659259 0.0001990509171164 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114568 COL4A2 CD93 COL4A2-CD93 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0036575642849855 0.8355319038299565 0.8817184225858201 0.8567148457705164 0.001123788079051 0.0003375370073613 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1114622 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Myoepithelial Cells Luminal-like Amorphous DCIS Cells -> Myoepithelial Cells 0.0036552777038175 0.2510234128936706 0.7373999388878224 0.2461374514707439 0.0009262556366009 0.0056518532344078 0.0 5.612932195779075e-05 0.0465082110550092 0.0 13362 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114642 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Myoepithelial Cells CXCL14+ Fibroblasts -> Myoepithelial Cells 0.0036543635627598 0.940547666092272 0.4630027772793905 0.7204611100467462 0.0001298888146421 0.0058437228618857 0.0 0.0 0.0 0.0 1884 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1114683 THBS2 CD36 THBS2-CD36 B Cells Plasma Cells B Cells -> Plasma Cells 0.0036527453246556 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0008527942416386 0.0009761781830445 0.0 0.0001402918069584 0.054074592785317 0.0 297 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114688 CD34 SELP CD34-SELP Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.003652474232294 0.2491449441646273 0.4623922682986163 0.2461374514707439 0.0003767662344862 0.0222228052993653 0.0 0.0 0.0 0.0 89 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1114721 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0036515537991196 0.785133132759182 0.6331674633943454 0.6198216015396206 0.001039571291679 0.0007400708115376 0.0 0.0 0.0 0.0 32 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1114733 VWF SELP VWF-SELP Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0036511679415148 0.7848266128497919 0.4623922682986163 0.7204611100467462 0.0004024409845247 0.0022515473538965 0.0 0.0 0.0 0.0 37 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1114759 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0036501278294276 0.2491449441646273 0.7760344326192508 0.2461374514707439 0.0108445362943651 0.0004582650848664 0.0 0.0 0.0 0.0 176 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1114824 COL4A1 CD93 COL4A1-CD93 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0036475428883947 0.4604235282221027 0.6587114738285964 0.6198216015396206 0.0017253404164066 0.0007261054236978 0.0 0.0 0.0 0.0 8 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1114903 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0036439708174131 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0036991419150414 0.0016667952436519 0.0 0.0 0.0 0.0 176 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1114954 VWF ITGA9 VWF-ITGA9 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0036420205445775 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0001077515101466 0.0565946652887153 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1114979 COL4A1 CD93 COL4A1-CD93 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0036409495237359 0.7766289238087107 0.8347945881127203 1.0 0.0002970267018348 0.0012097093680331 0.0 0.0 0.0 0.0 14 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1114986 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0036406823491616 0.7205550478301406 0.2491545808994955 0.2461374514707439 0.0117842887908422 0.0004471667362236 0.0 0.0 0.0 0.0 230 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1115034 THBS2 CD36 THBS2-CD36 B Cells B Cells B Cells -> B Cells 0.0036382423153419 0.6242573126045354 0.6176321640000088 1.0 0.0008527942416386 0.0007053434767499 0.0 2.938410907381288e-05 0.0141971181017852 0.0 1418 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115063 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0036371422266403 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0001826541344284 0.0326412663903893 0.0 0.0 0.0 0.0 184 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115114 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.003634916380603 0.6332974881236617 0.8755243548400705 0.6198216015396206 0.0016171311116606 0.0004150165744076 0.0 0.0 0.0 0.0 130 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115119 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.003634818392736 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0033537993821664 0.0018097844702233 0.0 0.0 0.0 0.0 26 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115157 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (Mitotic) 0.0036331170907438 0.6242573126045354 0.6176321640000088 0.9592803095773328 0.0001959417442809 0.0031731220372828 0.0 0.0001129177958446 0.0506199174187994 0.0 1476 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115217 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0036310858583399 0.7205550478301406 0.7830372268649692 0.7204611100467462 0.0002165306714062 0.0026038611777234 0.0 0.0 0.0 0.0 43 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1115242 VWF SELP VWF-SELP B Cells Myoepithelial Cells B Cells -> Myoepithelial Cells 0.0036299947654748 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.00023686843287 0.0053213839468185 0.0 0.000183284457478 0.0837463187668989 0.0 496 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1115357 THBS2 CD36 THBS2-CD36 Myeloid Cells Luminal-like Amorphous DCIS Cells Myeloid Cells -> Luminal-like Amorphous DCIS Cells 0.003625453921473 0.7809827257946271 0.2562573700401372 0.2461374514707439 0.0004779710276932 0.0096442330625583 0.0 0.0 0.0 0.0 122 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115359 HSPG2 LRP1 HSPG2-LRP1 B Cells Mast Cells B Cells -> Mast Cells 0.003625337636546 0.7789175740361626 0.8755243548400705 0.6198216015396206 0.0012941512528773 0.0004150165744076 0.0 0.0001431844215349 0.0199020817577518 0.0 97 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115367 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Mast Cells Macrophages -> Mast Cells 0.0036251195630807 0.8949858186325867 0.8341464445360613 0.8567148457705164 0.001895566065636 0.0001871866311057 0.0 0.0 0.0 0.0 165 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1115389 MMRN2 CD93 MMRN2-CD93 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0036245394954052 0.7856500335676843 0.7779918296243433 0.6198216015396206 0.0005542667491398 0.001079730675535 0.0 0.0017361111111111 0.1906898184008951 0.0 144 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1115445 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) CAFs, Invasive Associated 11q13 Invasive Tumor Cells (G1/S) -> CAFs, Invasive Associated 0.0036219579678238 0.6242573126045354 0.6176321640000088 0.9161861017439124 0.0001959417442809 0.0032616151102094 0.0 0.0 0.0 0.0 408 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115449 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0036218486855069 0.785133132759182 0.8537710813834968 0.7827641335561659 0.001039571291679 0.0004138063814779 0.0 0.0 0.0 0.0 23 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115560 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0036177452369935 0.6160088550075702 0.6631822525600675 1.0 0.0001971810371238 0.0027830389352876 0.0 0.0 0.0 0.0 1846 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1115586 C3 LRP1 C3-LRP1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0036166559425739 0.9487258305485792 0.2550748532138862 0.2461374514707439 0.0110943464444434 0.0003386430177035 0.0 0.0 0.0 0.0 19 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1115663 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells T Lymphocytes Luminal-like Amorphous DCIS Cells -> T Lymphocytes 0.0036137881382636 0.2510234128936706 0.6176321640000088 0.2461374514707439 0.0009262556366009 0.0063011237754475 0.0 0.0 0.0 0.0 316 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115710 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0036121277642306 0.6332974881236617 0.8755243548400705 0.6198216015396206 0.0015572459193676 0.0004150165744076 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115778 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0036089501491433 0.7753420160918723 0.8755243548400705 0.8567148457705164 0.0009153913192522 0.0004150165744076 0.0 0.0 0.0 0.0 137 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1115815 VWF LRP1 VWF-LRP1 B Cells Plasma Cells B Cells -> Plasma Cells 0.0036076472095852 0.6332974881236617 0.7346293219749174 0.6198216015396206 0.00023686843287 0.0032275631628407 0.0 0.0 0.0 0.0 297 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115822 CCN1 CAV1 CCN1-CAV1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0036074674063535 0.7324582304061453 0.252518874138558 0.2461374514707439 0.0025580826958339 0.0018925243453249 0.0 0.0 0.0 0.0 24 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1115848 VWF LRP1 VWF-LRP1 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0036062470302235 0.7848266128497919 0.6207977546603366 0.6198216015396206 0.0004024409845247 0.0018097844702233 0.0 0.0 0.0 0.0 32 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1115923 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0036027842976556 0.8571898293845529 0.9003264838243337 0.8567148457705164 0.0004196880356983 0.0007880862995141 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1115953 MMRN2 CD93 MMRN2-CD93 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0036017777999362 0.8571898293845529 0.7461459456652184 0.7827641335561659 0.0004196880356983 0.0010390313650636 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1115992 CD34 SELP CD34-SELP B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0035999396844437 0.633566764858408 0.6572093097629401 0.7917001487310438 0.0006336851232098 0.0010419094417808 0.0 0.0 0.0 0.0 42 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1116036 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0035980370043047 0.7719609236370527 0.7763428264267787 1.0 0.0014378253178126 0.0002517784065132 0.0 0.0 0.0 0.0 4019 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1116040 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.00359782815597 0.6301823358791634 0.7461459456652184 0.6198216015396206 0.000716220684292 0.0010390313650636 0.0 0.0 0.0 0.0 21 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116089 COL4A1 CD93 COL4A1-CD93 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0035957025524512 0.7463064942968751 0.8817184225858201 0.7827641335561659 0.0012430446376512 0.0003375370073613 0.0 0.0 0.0 0.0 527 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1116097 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0035950368200753 0.6301823358791634 0.6587114738285964 1.0 0.000716220684292 0.0007261054236978 0.0 0.0 0.0 0.0 1846 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116105 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0035947305145265 0.7468485855611411 0.7769451595923457 1.0 0.0006689050756654 0.0005558995075445 0.0 6.134668237141735e-05 0.0090663861928663 0.0 1132 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116109 A2M LRP1 A2M-LRP1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0035944228866792 0.7460047258226694 0.8755243548400705 0.7827641335561659 0.0010163752993685 0.0004150165744076 0.0 0.0 0.0 0.0 23 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1116175 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0035913227473174 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0014431743145616 0.0004089864655001 0.0 0.0 0.0 0.0 339 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116228 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0035889583191248 0.2486570577556728 0.4623922682986163 0.2461374514707439 0.0033537993821664 0.0022515473538965 0.0 0.0 0.0 0.0 272 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1116271 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0035875275877712 0.940547666092272 0.6587114738285964 0.6198216015396206 0.0001298888146421 0.0042738820064046 0.0 0.0 0.0 0.0 1422 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116275 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0035874150966938 0.940547666092272 0.6347970925105053 0.6198216015396206 0.0001298888146421 0.0044340558155446 0.0 0.0 0.0 0.0 390 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116283 VWF SELP VWF-SELP Plasma Cells CAFs, Invasive Associated Plasma Cells -> CAFs, Invasive Associated 0.0035870984024061 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0003457348439318 0.002113171886167 0.0 0.0 0.0 0.0 285 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1116331 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0035852984814511 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0033537993821664 0.0016667952436519 0.0 6.456611570247934e-05 0.0080248199107269 0.0 176 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116347 VWF LRP1 VWF-LRP1 B Cells 11q13 Invasive Tumor Cells (Mitotic) B Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.003584827124058 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.00023686843287 0.0028784826949613 0.0 0.0 0.0 0.0 50 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116350 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0035847811944748 0.250044481781731 0.7779918296243433 0.2461374514707439 7.058774627838557e-05 0.0627790816848129 0.0 0.0 0.0 0.0 64 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116363 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0035841974827683 0.6319926036888139 0.6207977546603366 0.7917001487310438 0.0004094805141934 0.0016667952436519 0.0 0.0 0.0 0.0 38 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1116371 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0035838430162079 0.250044481781731 0.8514619504364779 0.2461374514707439 0.0070431301838115 0.0005740632036187 0.0 0.0 0.0 0.0 34 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116372 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.00358382470526 0.6342079770588467 0.7754072541855492 0.7917001487310438 0.000895875398841 0.0006074333625108 0.0 0.0 0.0 0.0 38 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1116379 MMRN2 CD93 MMRN2-CD93 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0035836794151451 0.893316592628645 0.4630027772793905 0.7204611100467462 0.0007691101630988 0.0009242223287825 0.0 0.0 0.0 0.0 326 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116380 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0035836675431247 0.7856500335676843 0.7154802332407408 0.7204611100467462 0.0005542667491398 0.0009436211854823 0.0 0.0 0.0 0.0 37 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116422 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Mast Cells B Cells -> Mast Cells 0.0035821570419455 0.6342079770588467 0.836885603004631 0.6198216015396206 0.0002327631000826 0.0027591088867233 0.0 0.0 0.0 0.0 97 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1116456 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0035805001558547 0.8560892486218385 0.8537710813834968 1.0 0.0006966068981631 0.0004138063814779 0.0 0.0 0.0 0.0 14 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116529 VWF LRP1 VWF-LRP1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0035775057043392 0.2486570577556728 0.9078204025796472 0.2461374514707439 0.0001077515101466 0.0350138403862125 0.0 0.0 0.0 0.0 9 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116621 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0035740337585529 0.6242573126045354 0.7763054211764489 0.6198216015396206 0.000393370777602 0.0017638974017382 0.0 0.0 0.0 0.0 23 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116679 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0035708946671675 0.250044481781731 0.6587114738285964 0.2461374514707439 0.0070431301838115 0.0007261054236978 0.0 0.0 0.0 0.0 26 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116802 VWF LRP1 VWF-LRP1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.003565396335467 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0001077515101466 0.0501711964086628 0.0 0.0007102272727272 0.0143981763181916 0.0 64 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116819 THBS2 CD36 THBS2-CD36 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0035648093770184 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0009736808737186 0.0007598956708367 0.0 0.0 0.0 0.0 8 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1116878 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0035623149264546 0.255669001367946 0.4600037439857229 0.2461374514707439 0.0002269856810233 0.0310998965832685 0.0 0.0 0.0 0.0 89 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1116924 MMRN2 CD93 MMRN2-CD93 Macrophages 11q13 Invasive Tumor Cells (G1/S) Macrophages -> 11q13 Invasive Tumor Cells (G1/S) 0.0035603651033869 0.893316592628645 0.6587114738285964 0.6198216015396206 0.0007691101630988 0.0007261054236978 0.0 0.0 0.0 0.0 129 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1116927 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0035603199352139 0.7800321422220979 0.2491073778594529 0.2461374514707439 0.0213929720256037 0.0001990509171164 0.0 0.0 0.0 0.0 86 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1116983 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0035582738055947 0.6342079770588467 0.7470475610360806 0.6198216015396206 0.000895875398841 0.0007714919761827 0.0 0.0 0.0 0.0 21 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1117014 VWF LRP1 VWF-LRP1 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0035571163684647 0.7848266128497919 0.6207977546603366 0.6198216015396206 0.0004024409845247 0.0016667952436519 0.0 0.0002367424242424 0.0294243396726654 0.0 144 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117077 VWF LRP1 VWF-LRP1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0035543178338263 0.2486570577556728 0.7346293219749174 0.2461374514707439 0.0001077515101466 0.0416128058995347 0.0 0.0001697875230425 0.0070398017882465 0.0 937 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117132 VWF ITGA9 VWF-ITGA9 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0035527404731622 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0001077515101466 0.0487643047611538 0.0 0.002840909090909 0.1112012844864508 0.0 64 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1117147 VWF ITGA9 VWF-ITGA9 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0035522978004416 0.9011206516381156 0.2531744428854943 0.2461374514707439 0.0008850282134344 0.0040430820937484 0.0 0.0 0.0 0.0 19 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1117164 MMRN2 CD93 MMRN2-CD93 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0035513285350726 0.8571898293845529 0.4630027772793905 0.2461374514707439 0.0004196880356983 0.0048929293424311 0.0 0.0 0.0 0.0 41 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1117174 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Dendritic Cells Plasma Cells -> Dendritic Cells 0.0035506014673955 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0002165306714062 0.003263637675389 0.0 0.0 0.0 0.0 271 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1117241 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0035472206831353 0.6303642896310324 0.8537710813834968 0.6198216015396206 0.0014431743145616 0.0004138063814779 0.0 0.005 0.7278835386338188 0.0 5 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117243 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0035470343896989 0.6561647292424944 0.2550748532138862 0.2461374514707439 0.0142750905665976 0.0003386430177035 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1117266 VWF LRP1 VWF-LRP1 Mast Cells 11q13 Invasive Tumor Cells (Mitotic) Mast Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0035456520546464 0.8525936146535493 0.6207977546603366 0.6198216015396206 0.0002103933337194 0.0028784826949613 0.0 0.0 0.0 0.0 10 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117273 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0035454227770482 0.250044481781731 0.944024288971064 0.2461374514707439 7.058774627838557e-05 0.0484215930647349 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1117282 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.003545092173605 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.000716220684292 0.0007880862995141 0.0 0.0 0.0 0.0 380 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1117309 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0035439809620533 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0002269856810233 0.0178869147172998 0.0 0.0 0.0 0.0 15 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1117325 THBS2 CD36 THBS2-CD36 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0035430495089096 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0008527942416386 0.0007598956708367 0.0 0.0 0.0 0.0 42 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117346 VWF SELP VWF-SELP Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0035423169663704 0.8525936146535493 0.4623922682986163 0.2461374514707439 0.0002103933337194 0.0096770075292062 0.0 0.0 0.0 0.0 41 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1117381 VEGFC FLT1 VEGFC-FLT1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0035408583115085 0.8317042416754105 0.878254460598671 0.8567148457705164 0.0005440770361181 0.0005788283879716 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1117419 CCN1 CAV1 CCN1-CAV1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0035387904110023 0.2542249848376565 0.62431395375366 0.2461374514707439 0.0014656941948563 0.0034299077593249 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1117457 VWF SELP VWF-SELP CXCL14+ Fibroblasts CAFs, Invasive Associated CXCL14+ Fibroblasts -> CAFs, Invasive Associated 0.0035365977609931 0.9275752708651288 0.6572093097629401 0.6198216015396206 0.000245041593909 0.002113171886167 0.0 0.0 0.0 0.0 1422 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1117506 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0035349795917726 0.7856500335676843 0.6347970925105053 0.6198216015396206 0.0005542667491398 0.0011388334136451 0.0 0.0 0.0 0.0 32 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1117517 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0035345690691154 0.940547666092272 0.7830372268649692 0.7827641335561659 0.0001298888146421 0.0026038611777234 0.0 0.0 0.0 0.0 526 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1117521 C3 LRP1 C3-LRP1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0035344704613961 0.8509500867818902 0.8755243548400705 1.0 0.0006305085967044 0.0004150165744076 0.0 0.0 0.0 0.0 14 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1117550 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0035334077541835 0.9184503888425788 0.7470475610360806 0.7827641335561659 0.0004696576149175 0.0007714919761827 0.0 0.0 0.0 0.0 526 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1117573 MMP2 PECAM1 MMP2-PECAM1 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0035327749654446 0.8560892486218385 0.930308383061206 0.8567148457705164 0.0006966068981631 0.0004089864655001 0.0 0.0 0.0 0.0 148 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117622 THBS2 CD36 THBS2-CD36 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0035303401217364 0.7809827257946271 0.7373999388878224 0.7204611100467462 0.0004779710276932 0.0009761781830445 0.0 0.0 0.0 0.0 37 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117670 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Mast Cells T Lymphocytes -> Mast Cells 0.0035280766777923 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0006856224272495 0.0006800116997025 0.0 7.150007150007149e-05 0.0061433274429664 0.0 333 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1117714 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0035266760557647 0.255669001367946 0.4600037439857229 0.2461374514707439 0.0002269856810233 0.0292791515533623 0.0 0.0121212121212121 0.2862106011150586 0.0 15 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1117740 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0035253422287457 0.255669001367946 0.4596166826058663 0.2461374514707439 0.0002269856810233 0.0292373734098458 0.0 0.0001455321626079 0.0222235905639043 0.0 937 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1117777 THBS2 CD36 THBS2-CD36 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0035235020200577 0.724503440376099 0.8765901449012573 0.7204611100467462 0.0009736808737186 0.0004295051170816 0.0 0.0 0.0 0.0 48 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117802 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0035223888157423 0.662063103571249 0.2491073778594529 0.2461374514707439 0.0236359933700329 0.0001990509171164 0.0 0.0 0.0 0.0 4 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1117806 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0035222802196963 0.6626993710110988 0.2550748532138862 0.2461374514707439 0.0135527119637784 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1117830 THBS2 CD36 THBS2-CD36 Plasma Cells B Cells Plasma Cells -> B Cells 0.0035208227830552 0.724503440376099 0.6176321640000088 0.6198216015396206 0.0009736808737186 0.0007053434767499 0.0 0.0001322751322751 0.0639095665661316 0.0 315 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117847 VWF SELP VWF-SELP B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0035199437485622 0.6332974881236617 0.7478729882108823 0.6198216015396206 0.00023686843287 0.0027351735586246 0.0 0.0 0.0 0.0 137 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1117865 THBS2 CD36 THBS2-CD36 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0035190942585484 0.8581959463413404 0.8587566561291643 0.8567148457705164 0.0002636300075004 0.0011409783203169 0.0 0.0 0.0 0.0 148 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1117933 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0035161138430102 0.255669001367946 0.4600037439857229 0.3990376746076917 0.0002269856810233 0.017738069381683 0.0 0.0 0.0 0.0 89 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1117934 C3 LRP1 C3-LRP1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0035160744499001 0.2485046029682279 0.7346293219749174 0.2461374514707439 0.0013028322726017 0.0032275631628407 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1117941 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0035158550906025 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.000716220684292 0.0009436211854823 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1117968 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0035145470899077 0.9184503888425788 0.896164124004365 1.0 0.0004696576149175 0.0004874986369898 0.0 0.0 0.0 0.0 4019 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1118024 CD34 SELP CD34-SELP B Cells Mast Cells B Cells -> Mast Cells 0.0035125861560277 0.633566764858408 0.8347297932672282 0.6198216015396206 0.0006336851232098 0.0009042150166242 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1118059 MMRN2 CD93 MMRN2-CD93 Mast Cells B Cells Mast Cells -> B Cells 0.003510986786293 0.8571898293845529 0.7779918296243433 0.6198216015396206 0.0004196880356983 0.001079730675535 0.0 0.0 0.0 0.0 112 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1118061 VWF SELP VWF-SELP B Cells Macrophages B Cells -> Macrophages 0.0035108619495786 0.6332974881236617 0.941479368642921 0.6198216015396206 0.00023686843287 0.0021392900294222 0.0 0.0 0.0 0.0 1065 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1118101 VWF SELP VWF-SELP Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0035087843753002 0.7848266128497919 0.8347297932672282 0.7827641335561659 0.0004024409845247 0.0009042150166242 0.0 0.0 0.0 0.0 23 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1118182 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0035052662968816 0.250044481781731 0.4630027772793905 0.2461374514707439 0.0070431301838115 0.0009242223287825 0.0 0.0 0.0 0.0 272 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1118183 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.003505150901988 0.2490567623945399 0.6580560501976399 0.2461374514707439 0.000126812416921 0.0362497659817488 0.0 0.0 0.0 0.0 4 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1118242 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0035026319702896 0.250044481781731 0.6347970925105053 0.2461374514707439 0.0070431301838115 0.000671064546954 0.0 0.002840909090909 0.9422302550267788 0.0 176 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1118244 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0035025122901249 0.4629984640915818 0.7769451595923457 0.7204611100467462 0.0012814156885439 0.0005558995075445 0.0 0.000968992248062 0.143206732609182 0.0 43 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1118267 C1QB LRP1 C1QB-LRP1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0035015579517746 0.7753420160918723 0.2550748532138862 0.2461374514707439 0.0111808254589153 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1118310 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Basal-like Structured DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Basal-like Structured DCIS Cells 0.003498932236329 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0001959417442809 0.0030676679668133 0.0 0.0 0.0 0.0 1187 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1118346 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0034964693498993 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.0003521782369754 0.0016667952436519 0.0 0.0 0.0 0.0 38 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1118406 C3 LRP1 C3-LRP1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0034934103258355 0.7796725988275006 0.8755243548400705 0.7827641335561659 0.000819605673545 0.0004150165744076 0.0 0.0021739130434782 0.6265863724992289 0.0 23 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1118409 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0034932355928087 0.2534163760166434 0.7470475610360806 0.2461374514707439 0.0050543892975134 0.0007714919761827 0.0 0.0 0.0 0.0 20 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1118419 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.003492577280506 0.8516956437178343 0.7470475610360806 0.7827641335561659 0.000472352586488 0.0007714919761827 0.0 0.0 0.0 0.0 23 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1118420 MMRN2 CD93 MMRN2-CD93 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0034925183148877 0.893316592628645 0.8817184225858201 0.8875000050982297 0.0007691101630988 0.0003375370073613 0.0 0.0 0.0 0.0 1462 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1118426 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages B Cells Macrophages -> B Cells 0.0034923036939979 0.893316592628645 0.6347970925105053 0.6198216015396206 0.0007691101630988 0.000671064546954 0.0 0.0 0.0 0.0 1074 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1118429 C3 LRP1 C3-LRP1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0034922438784352 0.8509500867818902 0.7769451595923457 0.7827641335561659 0.0006305085967044 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1118504 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0034887350160898 0.6160088550075702 0.7447682696221608 0.6198216015396206 0.0001971810371238 0.0032154705418133 0.0 0.0 0.0 0.0 21 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1118592 MMRN2 CD93 MMRN2-CD93 Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0034849773662237 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0015409900107563 0.0003375370073613 0.0 0.0 0.0 0.0 922 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1118597 VWF SELP VWF-SELP Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0034846646835099 0.2486570577556728 0.6572093097629401 0.2461374514707439 0.0001077515101466 0.04130664769978 0.0 0.0 0.0 0.0 184 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1118651 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0034815050991932 0.2542249848376565 0.252518874138558 1.0 0.0014656941948563 0.0018925243453249 0.0 0.0007736293306424 0.042854355267235 0.0 991 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1118728 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0034773396600897 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0131302879503246 0.0003386430177035 0.0 0.0001269680040629 0.0081804888523796 0.0 179 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1118756 CD34 SELP CD34-SELP Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0034761235756211 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0042829523358709 0.0001189339410417 0.0 0.0 0.0 0.0 922 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1118802 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Mast Cells Dendritic Cells -> Mast Cells 0.0034742301751333 0.6342079770588467 0.8341464445360613 0.6198216015396206 0.0028649117803088 0.0001871866311057 0.0 0.0 0.0 0.0 151 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1118804 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0034742234465378 0.8571898293845529 0.8514619504364779 1.0 0.0004196880356983 0.0005740632036187 0.0 0.0 0.0 0.0 14 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1118806 VWF SELP VWF-SELP Macrophages B Cells Macrophages -> B Cells 0.0034740533869334 0.9011206516381156 0.7760344326192508 0.6198216015396206 0.0008850282134344 0.0004582650848664 0.0 0.0 0.0 0.0 1074 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1118836 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0034725980739888 0.2534163760166434 0.7746834992804791 0.2461374514707439 0.0050543892975134 0.00071798405859 0.0 0.0 0.0 0.0 11 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1118859 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0034713953058942 0.8571898293845529 0.7154802332407408 0.7204611100467462 0.0004196880356983 0.0009436211854823 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1118872 VWF ITGA9 VWF-ITGA9 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.003470675019521 0.6332974881236617 0.950463483645931 0.6198216015396206 0.00023686843287 0.0019776346124415 0.0 0.0 0.0 0.0 800 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1118913 C3 LRP1 C3-LRP1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0034684842316694 0.8911088195487638 0.2550748532138862 0.2461374514707439 0.0091898156146168 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1118918 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0034683582121821 0.4619393085577573 0.2491073778594529 0.2461374514707439 0.0308750930304183 0.0001990509171164 0.0 0.0001787416587225 0.2942433717620631 0.0 1049 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1118927 VWF ITGA9 VWF-ITGA9 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0034677631035774 0.2486570577556728 0.2531744428854943 0.3990376746076917 0.0001077515101466 0.0642389143033604 0.0 0.0 0.0 0.0 89 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1118937 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Plasma Cells B Cells -> Plasma Cells 0.0034671657762902 0.6342079770588467 0.4641352222874551 0.6198216015396206 0.0002327631000826 0.0040904475843412 0.0 0.0 0.0 0.0 297 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1118966 MMP2 PECAM1 MMP2-PECAM1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.003465476180377 0.8560892486218385 0.6331674633943454 0.6198216015396206 0.0006966068981631 0.0007400708115376 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1119028 VWF LRP1 VWF-LRP1 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0034625795410894 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0003457348439318 0.0018097844702233 0.0 0.0 0.0 0.0 8 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1119052 VWF SELP VWF-SELP Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0034612456771302 0.2486570577556728 0.7760344326192508 0.2461374514707439 0.0001077515101466 0.0335947364052305 0.0 0.0 0.0 0.0 74 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1119125 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0034572584355631 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.00146889578236 0.0003375370073613 0.0 0.0 0.0 0.0 1490 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1119142 VWF SELP VWF-SELP CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0034563560360637 0.9275752708651288 0.4623922682986163 0.7204611100467462 0.000245041593909 0.0022515473538965 0.0 0.0 0.0 0.0 285 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1119155 COL4A1 CD93 COL4A1-CD93 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0034558238188453 0.4604235282221027 0.8817184225858201 0.7204611100467462 0.0017253404164066 0.0003375370073613 0.0 0.0 0.0 0.0 306 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1119159 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0034557216621634 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0003788349535045 0.0021449819680126 0.0 0.0 0.0 0.0 37 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1119216 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0034530085883955 0.2490567623945399 0.4641352222874551 0.2461374514707439 0.000126812416921 0.046975263367762 0.0 0.0 0.0 0.0 89 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1119261 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0034506775000388 0.6303682835571691 0.4614667734221426 1.0 0.0002705513462707 0.0021449819680126 0.0 0.000168265185933 0.0061066710935091 0.0 283 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1119265 CCN1 CAV1 CCN1-CAV1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0034504319590184 0.6213271600240247 0.252518874138558 0.2461374514707439 0.0023088899408624 0.0018925243453249 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1119341 CD34 SELP CD34-SELP Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0034465422098297 0.2491449441646273 0.4623922682986163 0.3990376746076917 0.0003767662344862 0.0096770075292062 0.0 0.0 0.0 0.0 89 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1119377 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0034448203471972 0.9097736029185508 0.0 0.2461374514707439 0.0430965463818576 0.0107131540183669 0.0016163127628302 0.0128996843694249 0.4026518497145026 0.0028818443804034 694 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1119381 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0034446962758974 0.7719609236370527 0.6614977577544194 0.6198216015396206 0.0014378253178126 0.0003671083100858 0.0 0.0 0.0 0.0 409 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1119402 MMRN2 CD93 MMRN2-CD93 Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0034435734619366 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0002165306714062 0.0026174949623928 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1119416 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0034431283180987 0.7856500335676843 0.8514619504364779 0.7827641335561659 0.0005542667491398 0.0005740632036187 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1119431 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0034426694437009 0.4601010570874773 0.2550748532138862 0.2461374514707439 0.0170183763647696 0.0003386430177035 0.0 0.0002383222116301 0.0148026218403803 0.0 1049 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1119529 VWF SELP VWF-SELP B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0034383006702685 0.6332974881236617 0.4623922682986163 0.2461374514707439 0.00023686843287 0.0096770075292062 0.0 0.0004308487720809 0.1229128461900837 0.0 211 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1119547 VWF SELP VWF-SELP B Cells CAFs, Invasive Associated B Cells -> CAFs, Invasive Associated 0.0034373395603745 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.00023686843287 0.002113171886167 0.0 0.0 0.0 0.0 968 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1119566 CD34 SELP CD34-SELP CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0034359292992954 0.9303167350027568 0.8819126042133903 1.0 0.0016860250240652 0.0001189339410417 0.0 0.0 0.0 0.0 4019 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1119578 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0034350023295038 0.2451358214448441 0.773263018678637 0.2461374514707439 0.0010709508378277 0.0032875740549697 0.0 0.0 0.0 0.0 15 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1119639 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0034321751534027 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0002269856810233 0.0147571931436988 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1119658 MMRN2 CD93 MMRN2-CD93 B Cells B Cells B Cells -> B Cells 0.0034314637953214 0.6301823358791634 0.7779918296243433 1.0 0.0003083910058032 0.001079730675535 0.0 0.0005289139633286 0.0580945003872967 0.0 1418 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1119796 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0034242326928049 0.8571898293845529 0.6347970925105053 0.6198216015396206 0.0004196880356983 0.0011388334136451 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1119816 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0034234090160434 0.2490567623945399 0.4638256179742202 0.2461374514707439 0.000126812416921 0.0446401662952339 0.0 0.0 0.0 0.0 937 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1119909 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0034192135404874 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.011891719340537 0.0003386430177035 0.0 0.0 0.0 0.0 179 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1119940 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Mast Cells B Cells -> Mast Cells 0.0034175543009472 0.6249837837987587 0.8341464445360613 0.6198216015396206 0.00263399584678 0.0001871866311057 0.0 0.0 0.0 0.0 97 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1119984 VWF LRP1 VWF-LRP1 Plasma Cells B Cells Plasma Cells -> B Cells 0.0034154061714282 0.7158082793127664 0.6207977546603366 0.6198216015396206 0.0003457348439318 0.0016667952436519 0.0 3.607503607503608e-05 0.0044837089025013 0.0 315 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1120017 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0034138319272377 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.000245041593909 0.0018097844702233 0.0 0.0001111358079573 0.0115452758365836 0.0 409 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1120070 CD34 SELP CD34-SELP Mast Cells B Cells Mast Cells -> B Cells 0.0034112224099081 0.8532069650852002 0.7760344326192508 0.6198216015396206 0.00083777361258 0.0004582650848664 0.0 0.0 0.0 0.0 112 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1120072 A2M LRP1 A2M-LRP1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0034110023179977 0.8392912392980421 0.8755243548400705 1.0 0.0005164482812395 0.0004150165744076 0.0 0.0029761904761904 0.4329004329004329 0.0 14 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1120106 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Dendritic Cells CXCL14+ Fibroblasts -> Dendritic Cells 0.0034087761846582 0.940547666092272 0.6347970925105053 0.6198216015396206 0.0001298888146421 0.003263637675389 0.0 0.0 0.0 0.0 887 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1120232 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0034030731108232 0.4629984640915818 0.8755243548400705 0.7204611100467462 0.0012814156885439 0.0004150165744076 0.0 0.0005787037037037 0.0804375804375805 0.0 48 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1120237 VWF LRP1 VWF-LRP1 B Cells B Cells B Cells -> B Cells 0.0034027343878258 0.6332974881236617 0.6207977546603366 1.0 0.00023686843287 0.0016667952436519 0.0 2.4041543787665083e-05 0.0029880852700026 0.0 1418 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1120257 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0034016520622603 0.2486570577556728 0.8347297932672282 0.2461374514707439 0.0033537993821664 0.0009042150166242 0.0 0.0 0.0 0.0 34 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1120295 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Macrophages B Cells -> Macrophages 0.0033999709914627 0.6342079770588467 0.8923034233058523 0.6198216015396206 0.0002327631000826 0.00189193058407 0.0 0.0 0.0 0.0 1065 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1120299 VWF SELP VWF-SELP Mast Cells CAFs, Invasive Associated Mast Cells -> CAFs, Invasive Associated 0.0033997762382926 0.8525936146535493 0.6572093097629401 0.6198216015396206 0.0002103933337194 0.002113171886167 0.0 0.0 0.0 0.0 144 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1120347 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0033977137855962 0.6342079770588467 0.896164124004365 0.6198216015396206 0.000895875398841 0.0004874986369898 0.0 0.0 0.0 0.0 380 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1120395 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0033947232724855 0.250044481781731 0.6347970925105053 0.2461374514707439 7.058774627838557e-05 0.0554888093272979 0.0 0.0 0.0 0.0 184 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1120412 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0033935434416603 0.6332974881236617 0.6572093097629401 1.0 0.0003521782369754 0.0010419094417808 0.0 4.924652811976756e-05 0.0290256835495441 0.0 1846 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1120442 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0033916752715284 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.000716220684292 0.000671064546954 0.0 0.0 0.0 0.0 38 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1120516 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.003387425613949 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.000895875398841 0.0009249287638231 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1120546 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Endothelial Cells B Cells -> Endothelial Cells 0.0033864431851218 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0001109003117737 0.0032875740549697 0.0 1.5778345798226513e-05 0.0025459147384646 0.0 1509 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1120567 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0033855379183913 0.8516956437178343 0.896164124004365 0.8567148457705164 0.000472352586488 0.0004874986369898 0.0 0.0 0.0 0.0 148 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1120641 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) -> Luminal-like Amorphous DCIS Cells 0.0033810363321955 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.000393370777602 0.0096442330625583 0.0 0.0 0.0 0.0 351 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1120661 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0033801227271217 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.000393370777602 0.0011409783203169 0.0 0.0 0.0 0.0 339 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1120673 VWF SELP VWF-SELP T Lymphocytes CXCL14+ Fibroblasts T Lymphocytes -> CXCL14+ Fibroblasts 0.0033789466486883 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0036144684673052 0.0001189339410417 0.0 0.0 0.0 0.0 1880 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1120682 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0033785190065246 0.9184503888425788 0.7746834992804791 0.6198216015396206 0.0004696576149175 0.00071798405859 0.0 0.0 0.0 0.0 791 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1120804 VWF SELP VWF-SELP CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0033719224073708 0.9275752708651288 0.8347297932672282 0.8567148457705164 0.000245041593909 0.0009042150166242 0.0 0.0 0.0 0.0 137 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1120834 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Macrophages B Cells -> Macrophages 0.0033704898246236 0.6301823358791634 0.9195415044619336 0.6198216015396206 0.0003083910058032 0.0013235329769289 0.0 0.0 0.0 0.0 1065 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1120840 A2M LRP1 A2M-LRP1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0033702508181807 0.8392912392980421 0.7769451595923457 0.7827641335561659 0.0005164482812395 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1120892 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0033673226836077 0.9275752708651288 0.6207977546603366 0.6198216015396206 0.000245041593909 0.0016667952436519 0.0 2.873232961728537e-05 0.003571095586063 0.0 791 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1121027 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0033601383045884 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.0003521782369754 0.0022515473538965 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1121029 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0033600719612978 0.2490567623945399 0.7754072541855492 0.2461374514707439 0.000126812416921 0.0238720285974944 0.0 0.0 0.0 0.0 74 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1121054 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0033590248708457 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0049987108499989 0.0007400708115376 0.0 0.0 0.0 0.0 26 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1121125 CD34 SELP CD34-SELP B Cells B Cells B Cells -> B Cells 0.0033556758401752 0.633566764858408 0.7760344326192508 1.0 0.0006336851232098 0.0004582650848664 0.0 0.0 0.0 0.0 1418 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1121156 C3 LRP1 C3-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0033541814151793 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0013028322726017 0.0028784826949613 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1121170 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0033529707878224 0.7468485855611411 0.8755243548400705 0.7827641335561659 0.0006689050756654 0.0004150165744076 0.0 0.0 0.0 0.0 23 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1121231 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0033498160810903 0.255669001367946 0.4600037439857229 0.2461374514707439 0.0002269856810233 0.0215025911544899 0.0 0.0001455321626079 0.0174836044177408 0.0 937 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1121236 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Myeloid Cells T Lymphocytes -> Myeloid Cells 0.0033494863105731 0.8630183004227985 0.7426180951053148 0.6198216015396206 0.0006856224272495 0.0005184623914895 0.0 6.595435958316844e-05 0.007758391543758 0.0 361 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1121285 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0033468978635758 0.2486570577556728 0.6572093097629401 0.2461374514707439 0.0033537993821664 0.0010419094417808 0.0 0.0 0.0 0.0 26 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1121321 COL4A1 CD93 COL4A1-CD93 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0033446591950164 0.7766289238087107 0.7461459456652184 0.7827641335561659 0.0002970267018348 0.0010390313650636 0.0 0.0 0.0 0.0 23 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1121423 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells B Cells Mast Cells -> B Cells 0.0033394783576775 0.8516956437178343 0.7746834992804791 0.6198216015396206 0.000472352586488 0.00071798405859 0.0 0.0 0.0 0.0 112 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1121490 THBS2 CD36 THBS2-CD36 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.0033351855786058 0.8581959463413404 0.2562573700401372 0.2461374514707439 0.0002636300075004 0.0096442330625583 0.0 0.0 0.0 0.0 41 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1121551 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Macrophages Plasma Cells -> Macrophages 0.0033318678250736 0.7205550478301406 0.9195415044619336 0.7204611100467462 0.0002165306714062 0.0013235329769289 0.0 0.0 0.0 0.0 337 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1121556 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0033316016309797 0.6301823358791634 0.8514619504364779 0.6198216015396206 0.000716220684292 0.0005740632036187 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1121568 VWF SELP VWF-SELP Myoepithelial Cells CXCL14+ Fibroblasts Myoepithelial Cells -> CXCL14+ Fibroblasts 0.0033311224574158 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0025256125075084 0.0001189339410417 0.0 0.0 0.0 0.0 1538 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1121585 VWF LRP1 VWF-LRP1 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0033302757857009 0.7848266128497919 0.7769451595923457 1.0 0.0004024409845247 0.0005558995075445 0.0 0.0001204625762929 0.0150920963590964 0.0 1132 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1121621 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Endothelial Cells Mast Cells -> Endothelial Cells 0.0033284033705718 0.6303682835571691 0.773263018678637 0.8567148457705164 9.902323108165852e-05 0.0032875740549697 0.0 0.000431331953071 0.0695975605134635 0.0 276 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1121667 VWF SELP VWF-SELP Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0033261067989096 0.8525936146535493 0.8347297932672282 1.0 0.0002103933337194 0.0009042150166242 0.0 0.0 0.0 0.0 14 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1121677 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0033255101684512 0.2534163760166434 0.4638256179742202 0.2461374514707439 0.0050543892975134 0.0009249287638231 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1121706 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Mast Cells CAFs, Invasive Associated -> Mast Cells 0.0033237097052074 0.6342079770588467 0.8341464445360613 0.6198216015396206 0.002196330917593 0.0001871866311057 0.0 0.0 0.0 0.0 130 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1121725 VWF SELP VWF-SELP Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0033227492636501 0.7158082793127664 0.8347297932672282 0.7204611100467462 0.0003457348439318 0.0009042150166242 0.0 0.0 0.0 0.0 48 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1121730 VWF SELP VWF-SELP Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0033226388514109 0.8525936146535493 0.4623922682986163 0.7204611100467462 0.0002103933337194 0.0022515473538965 0.0 0.0009090909090909 0.0877257921231863 0.0 50 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1121748 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Plasma Cells Myeloid Cells -> Plasma Cells 0.0033214051267825 0.7856500335676843 0.4630027772793905 0.7204611100467462 0.0005542667491398 0.0009242223287825 0.0 0.0 0.0 0.0 37 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1121770 VWF SELP VWF-SELP Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0033205896902861 0.7848266128497919 0.6572093097629401 0.6198216015396206 0.0004024409845247 0.0010419094417808 0.0 0.0 0.0 0.0 32 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1121810 VWF LRP1 VWF-LRP1 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0033180192741707 0.6332974881236617 0.6207977546603366 0.7917001487310438 0.00023686843287 0.0018097844702233 0.0 0.0002705627705627 0.0281072489116828 0.0 42 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1121822 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0033175751213088 0.9184503888425788 0.4638256179742202 0.7204611100467462 0.0004696576149175 0.0009249287638231 0.0 0.0 0.0 0.0 285 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1121845 THBS2 CD36 THBS2-CD36 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0033161730117294 0.9197297916541942 0.2562573700401372 0.2461374514707439 0.0087456089304998 0.0002621208738319 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1121901 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Macrophages CXCL14+ Fibroblasts -> Macrophages 0.0033119005972234 0.940547666092272 0.9195415044619336 0.8875000050982297 0.0001298888146421 0.0013235329769289 0.0 0.0 0.0 0.0 1424 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1122015 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (Mitotic) 0.0033060233075892 0.940547666092272 0.6587114738285964 0.6198216015396206 0.0001298888146421 0.0026174949623928 0.0 0.0019230769230769 0.6387261595557554 0.0 390 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1122049 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0033042096965074 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0003083910058032 0.0109188419829382 0.0 0.0 0.0 0.0 211 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1122135 MMRN2 CD93 MMRN2-CD93 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0032997970905631 0.7856500335676843 0.6587114738285964 0.6198216015396206 0.0005542667491398 0.0007261054236978 0.0 0.0 0.0 0.0 32 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1122147 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0032994198832505 0.250044481781731 0.8817184225858201 0.2461374514707439 0.0070431301838115 0.0003375370073613 0.0 0.0 0.0 0.0 1384 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1122190 COL4A1 CD93 COL4A1-CD93 Mast Cells Luminal-like Amorphous DCIS Cells Mast Cells -> Luminal-like Amorphous DCIS Cells 0.003297811330717 0.7766289238087107 0.4630027772793905 0.2461374514707439 0.0002970267018348 0.0048929293424311 0.0 0.0 0.0 0.0 41 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1122264 VWF ITGA9 VWF-ITGA9 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0032942812124356 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0001077515101466 0.0309945332907452 0.0 0.0012285012285012 0.0766325319187865 0.0 74 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1122322 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0032905077835032 0.6160088550075702 0.7462743270426613 0.6198216015396206 0.0001971810371238 0.0022591041672132 0.0 0.0 0.0 0.0 21 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1122405 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0032861807621843 0.9184503888425788 0.7754072541855492 0.6198216015396206 0.0004696576149175 0.0006074333625108 0.0 0.0 0.0 0.0 791 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1122431 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0032843263532951 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0001826541344284 0.0176963220730796 0.0 0.0 0.0 0.0 74 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1122450 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0032832608993599 0.7789175740361626 0.2550748532138862 0.2461374514707439 0.0075637985935472 0.0003386430177035 0.0 0.0 0.0 0.0 75 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1122477 VWF LRP1 VWF-LRP1 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0032817598867925 0.8525936146535493 0.6207977546603366 0.6198216015396206 0.0002103933337194 0.0018097844702233 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1122489 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0032809239579465 0.2490567623945399 0.6571792026963191 0.2461374514707439 0.000126812416921 0.0244129856070659 0.0 0.0 0.0 0.0 2 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1122509 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0032797018992294 0.6303682835571691 0.773263018678637 0.7827641335561659 0.0003788349535045 0.0008609682710384 0.0 0.0 0.0 0.0 527 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1122513 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0032792387126384 0.8516956437178343 0.4638256179742202 0.7204611100467462 0.000472352586488 0.0009249287638231 0.0 0.0 0.0 0.0 50 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1122525 THBS2 CD36 THBS2-CD36 B Cells Mast Cells B Cells -> Mast Cells 0.0032787562068722 0.6242573126045354 0.8765901449012573 0.6198216015396206 0.0008527942416386 0.0004295051170816 0.0 0.0 0.0 0.0 97 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1122544 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0032777944913449 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0161193721503025 0.0001990509171164 0.0 0.0003333333333333 0.223683344412274 0.0 75 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1122579 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0032763723741444 0.6303642896310324 0.930308383061206 0.6198216015396206 0.0008320501336843 0.0004089864655001 0.0 0.0 0.0 0.0 380 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1122582 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Plasma Cells Macrophages -> Plasma Cells 0.0032761165482632 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.0002750231449378 0.0021449819680126 0.0 0.0001460706982179 0.0053011899370033 0.0 326 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1122635 C3 LRP1 C3-LRP1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0032732577590228 0.8911088195487638 0.2550748532138862 0.2461374514707439 0.0064915662046245 0.0003386430177035 0.0 0.0 0.0 0.0 33 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1122642 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Myeloid Cells 11q13 Invasive Tumor Cells (Mitotic) -> Myeloid Cells 0.0032727739089848 0.6319926036888139 0.7769451595923457 0.6198216015396206 0.0007263013575398 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1122741 MMRN2 CD93 MMRN2-CD93 B Cells Mast Cells B Cells -> Mast Cells 0.0032672735692731 0.6301823358791634 0.8347945881127203 0.6198216015396206 0.0003083910058032 0.0012097093680331 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1122819 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0032621700038155 0.2451358214448441 0.0 0.3990376746076917 0.1327555461750915 0.0107131540183669 0.0008662502192242 0.0265095729013254 0.8274720728175426 0.0206185567010309 97 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1122845 COL4A1 CD93 COL4A1-CD93 Mast Cells B Cells Mast Cells -> B Cells 0.0032603494414796 0.7766289238087107 0.7779918296243433 0.6198216015396206 0.0002970267018348 0.001079730675535 0.0 0.0 0.0 0.0 112 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1122891 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0032585553716764 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.000716220684292 0.0009242223287825 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1122984 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0032522634461546 0.9067635403815892 0.2491073778594529 0.2461374514707439 0.0106922602624424 0.0001990509171164 0.0 0.0 0.0 0.0 29 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123063 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells B Cells Mast Cells -> B Cells 0.0032482071326333 0.8516956437178343 0.7754072541855492 0.6198216015396206 0.000472352586488 0.0006074333625108 0.0 0.0 0.0 0.0 112 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1123073 THBS2 CD36 THBS2-CD36 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0032476869701339 0.8581959463413404 0.7373999388878224 0.7204611100467462 0.0002636300075004 0.0009761781830445 0.0 0.0 0.0 0.0 50 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123105 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0032452376222023 0.7789175740361626 0.2550748532138862 0.2461374514707439 0.0070532058552773 0.0003386430177035 0.0 0.0 0.0 0.0 86 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123119 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0032444270354299 0.2491408586098361 0.930308383061206 0.2461374514707439 0.0049987108499989 0.0004089864655001 0.0 1.8063583815028903e-05 0.0328110848357606 0.0 1384 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123232 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells CAFs, Invasive Associated Luminal-like Amorphous DCIS Cells -> CAFs, Invasive Associated 0.0032381620475047 0.2510234128936706 0.6176321640000088 0.2461374514707439 0.0009262556366009 0.0032616151102094 0.0 0.0 0.0 0.0 147 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123256 VWF LRP1 VWF-LRP1 Mast Cells B Cells Mast Cells -> B Cells 0.0032370499615932 0.8525936146535493 0.6207977546603366 0.6198216015396206 0.0002103933337194 0.0016667952436519 0.0 0.0003043831168831 0.0378312938648555 0.0 112 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123261 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0032367168068956 0.7856500335676843 0.6347970925105053 0.6198216015396206 0.0005542667491398 0.000671064546954 0.0 0.0 0.0 0.0 144 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1123272 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0032361379549915 0.6303642896310324 0.8537710813834968 0.6198216015396206 0.0008320501336843 0.0004138063814779 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123371 MMRN2 CD93 MMRN2-CD93 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0032298343112163 0.7205550478301406 0.8347945881127203 0.7204611100467462 0.0002165306714062 0.0012097093680331 0.0 0.0 0.0 0.0 48 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1123489 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (Mitotic) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0032233509681432 0.2510234128936706 0.6176321640000088 0.2461374514707439 0.0009262556366009 0.0031731220372828 0.0 0.0001117068811438 0.0500770764813323 0.0 373 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123538 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0032202281799131 0.2490567623945399 0.8341464445360613 0.2461374514707439 0.011649387573427 0.0001871866311057 0.0 0.0 0.0 0.0 34 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1123560 MMRN2 CLEC14A MMRN2-CLEC14A B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0032188960362782 0.6301823358791634 0.6347970925105053 0.7917001487310438 0.0003083910058032 0.0011388334136451 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1123584 MMRN2 CD93 MMRN2-CD93 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0032173492734297 0.8571898293845529 0.4630027772793905 0.7204611100467462 0.0004196880356983 0.0009242223287825 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1123609 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (Mitotic) -> 11q13 Invasive Tumor Cells (G1/S) 0.0032156491042706 0.6242573126045354 0.6176321640000088 0.9592803095773328 0.000393370777602 0.0007598956708367 0.0 0.0 0.0 0.0 1495 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123617 CCN1 CAV1 CCN1-CAV1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0032155140293293 0.2542249848376565 0.62431395375366 0.2461374514707439 0.0014656941948563 0.0019304335593669 0.0 0.0 0.0 0.0 11 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1123662 THBS2 CD36 THBS2-CD36 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0032129922379595 0.7809827257946271 0.8765901449012573 0.7827641335561659 0.0004779710276932 0.0004295051170816 0.0 0.0 0.0 0.0 23 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123703 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Plasma Cells 11q13 Invasive Tumor Cells (Mitotic) -> Plasma Cells 0.0032108007617162 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.000393370777602 0.0009761781830445 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123727 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0032089722095864 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0141923232885854 0.0001990509171164 0.0 0.0 0.0 0.0 86 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123734 THBS2 CD36 THBS2-CD36 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0032084850294115 0.2510234128936706 0.7373999388878224 0.2461374514707439 5.260070730345377e-05 0.0455125113141721 0.0 0.0009363295880149 0.2129094454031757 0.0 89 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123762 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.003207111047675 0.7158082793127664 0.2550748532138862 0.2461374514707439 0.0071496754272206 0.0003386430177035 0.0 0.0 0.0 0.0 230 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123786 THBS2 CD36 THBS2-CD36 Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0032060335836132 0.7809827257946271 0.6176321640000088 0.6198216015396206 0.0004779710276932 0.0007598956708367 0.0 0.0 0.0 0.0 32 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123797 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Basal-like Structured DCIS Cells Luminal-like Amorphous DCIS Cells -> Basal-like Structured DCIS Cells 0.0032052447627427 0.2510234128936706 0.6176321640000088 0.2461374514707439 0.0009262556366009 0.0030676679668133 0.0 9.238728750923872e-05 0.0602136307466704 0.0 902 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123802 MMRN2 CD93 MMRN2-CD93 B Cells Luminal-like Amorphous DCIS Cells B Cells -> Luminal-like Amorphous DCIS Cells 0.0032049323154604 0.6301823358791634 0.4630027772793905 0.2461374514707439 0.0003083910058032 0.0048929293424311 0.0 0.0 0.0 0.0 211 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1123804 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0032047436667127 0.7800321422220979 0.2491073778594529 0.2461374514707439 0.0113788029360913 0.0001990509171164 0.0 0.0 0.0 0.0 75 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1123806 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0032045849105588 0.2491408586098361 0.8537710813834968 0.2461374514707439 0.0049987108499989 0.0004138063814779 0.0 0.0 0.0 0.0 34 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1123924 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0031970493730263 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0003788349535045 0.0008542071298387 0.0 0.0 0.0 0.0 144 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1123940 MMRN2 CD93 MMRN2-CD93 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0031964181924633 0.8571898293845529 0.6587114738285964 0.6198216015396206 0.0004196880356983 0.0007261054236978 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1124005 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0031916438809903 0.940547666092272 0.8347945881127203 0.8567148457705164 0.0001298888146421 0.0012097093680331 0.0 0.0 0.0 0.0 137 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1124034 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0031898316601516 0.7205550478301406 0.7154802332407408 1.0 0.0002165306714062 0.0009436211854823 0.0 0.0005889281507656 0.0655102809110564 0.0 283 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1124061 VWF SELP VWF-SELP Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0031883023624215 0.7158082793127664 0.6572093097629401 0.6198216015396206 0.0003457348439318 0.0010419094417808 0.0 0.0 0.0 0.0 8 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1124110 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0031854567039949 0.7205550478301406 0.2491545808994955 0.2461374514707439 0.0002165306714062 0.0109188419829382 0.0 0.0 0.0 0.0 271 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1124121 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0031847740700623 0.6332974881236617 0.8347297932672282 0.6198216015396206 0.0003521782369754 0.0009042150166242 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1124165 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0031821060567435 0.6242573126045354 0.7763054211764489 0.6198216015396206 0.0001959417442809 0.0017638974017382 0.0 0.0 0.0 0.0 21 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1124198 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0031801315978264 0.6160088550075702 0.4596166826058663 0.2461374514707439 0.0001971810371238 0.0075270071967493 0.0 0.0 0.0 0.0 19 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1124204 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0031798571896154 0.6319926036888139 0.8755243548400705 0.6198216015396206 0.0007263013575398 0.0004150165744076 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1124274 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0031750058781071 0.6303682835571691 0.773263018678637 0.8875000050982297 0.0002750231449378 0.0008609682710384 0.0 8.142792000521138e-05 0.0244291480985324 0.0 1462 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1124317 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0031729364687716 0.6589792304505506 0.2550748532138862 0.2461374514707439 0.0072827533047186 0.0003386430177035 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1124349 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0031700226049235 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0002269856810233 0.0091569531245039 0.0 0.0 0.0 0.0 9 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1124351 MMRN2 CD93 MMRN2-CD93 Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0031698726707451 0.7856500335676843 0.8817184225858201 0.7827641335561659 0.0005542667491398 0.0003375370073613 0.0 0.0 0.0 0.0 527 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1124405 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0031667861200883 0.2491408586098361 0.7167436199046466 0.2461374514707439 0.0001826541344284 0.0125623889131764 0.0 0.0002808988764044 0.0904853961341004 0.0 89 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1124410 THBS2 CD36 THBS2-CD36 Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0031664739655355 0.7809827257946271 0.6176321640000088 0.6198216015396206 0.0004779710276932 0.0007053434767499 0.0 0.0 0.0 0.0 144 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1124450 MMP2 PECAM1 MMP2-PECAM1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0031640817712698 0.9330801352629944 0.2491073778594529 0.2461374514707439 0.0088108219576754 0.0001990509171164 0.0 0.0 0.0 0.0 19 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1124570 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0031576782188447 0.7160288858520609 0.8341464445360613 0.7204611100467462 0.0012306151710811 0.0001871866311057 0.0 0.0034722222222222 1.0 0.0 48 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1124604 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0031556193866106 0.6303682835571691 0.4614667734221426 0.7204611100467462 0.000219642761279 0.0021449819680126 0.0 0.0 0.0 0.0 285 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1124616 CD34 SELP CD34-SELP Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0031550313494005 0.7168245244832976 0.8819126042133903 0.7204611100467462 0.0018206581062216 0.0001189339410417 0.0 0.0 0.0 0.0 306 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1124648 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0031534739206693 0.6561647292424944 0.2550748532138862 0.2461374514707439 0.0070489045197697 0.0003386430177035 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1124652 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0031532335207194 0.6303682835571691 0.773263018678637 0.7827641335561659 0.0003788349535045 0.0006800116997025 0.0 0.0 0.0 0.0 23 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1124692 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0031503154791399 0.2542249848376565 0.7832252605020791 0.2461374514707439 0.0014656941948563 0.00136079311934 0.0 0.0 0.0 0.0 20 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1124694 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0031501758804681 0.2485046029682279 0.7769451595923457 0.2461374514707439 0.0036991419150414 0.0005558995075445 0.0 0.000297619047619 0.0667214985052566 0.0 84 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1124770 VWF SELP VWF-SELP B Cells Plasma Cells B Cells -> Plasma Cells 0.0031452048203883 0.6332974881236617 0.4623922682986163 0.6198216015396206 0.00023686843287 0.0022515473538965 0.0 0.000153045607591 0.0147686518725902 0.0 297 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1124809 VWF SELP VWF-SELP CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0031434161350983 0.9275752708651288 0.6572093097629401 0.6198216015396206 0.000245041593909 0.0010419094417808 0.0 0.0 0.0 0.0 409 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1124937 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells B Cells Mast Cells -> B Cells 0.003135314142497 0.8571898293845529 0.6347970925105053 0.6198216015396206 0.0004196880356983 0.000671064546954 0.0 0.0 0.0 0.0 112 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125065 MMRN2 CD93 MMRN2-CD93 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0031264457220669 0.6301823358791634 0.7461459456652184 0.6198216015396206 0.0003083910058032 0.0010390313650636 0.0 0.0 0.0 0.0 137 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125103 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0031237745516218 0.6160088550075702 0.7754239189773715 0.6198216015396206 0.0001971810371238 0.0015914585039484 0.0 0.0 0.0 0.0 380 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1125171 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0031196682400347 0.6303682835571691 0.773263018678637 1.0 0.000219642761279 0.0008609682710384 0.0 2.9621204042701927e-05 0.0088866420801329 0.0 4019 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1125195 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Myeloid Cells Myeloid Cells -> Myeloid Cells 0.0031183474752456 0.6303682835571691 0.7426180951053148 1.0 0.0003788349535045 0.0005184623914895 0.0 0.0009885579673565 0.1162867750202669 0.0 1132 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1125197 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0031182968469848 0.8911088195487638 0.2550748532138862 0.2461374514707439 0.0048525806497539 0.0003386430177035 0.0 0.0 0.0 0.0 29 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1125218 MMRN2 CD93 MMRN2-CD93 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0031171119862127 0.8571898293845529 0.8817184225858201 0.8567148457705164 0.0004196880356983 0.0003375370073613 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125302 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0031130454855495 0.250044481781731 0.7154802332407408 0.2461374514707439 7.058774627838557e-05 0.0292771742399634 0.0 0.0037453183520599 0.4290606581351035 0.0 89 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125402 VWF LRP1 VWF-LRP1 Myeloid Cells Mast Cells Myeloid Cells -> Mast Cells 0.0031063016767805 0.7848266128497919 0.8755243548400705 0.7827641335561659 0.0004024409845247 0.0004150165744076 0.0 0.0 0.0 0.0 23 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1125427 C3 LRP1 C3-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0031045398284176 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0013028322726017 0.0018097844702233 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1125495 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.0030994542400216 0.2486570577556728 0.7769451595923457 0.2461374514707439 0.0033537993821664 0.0005558995075445 0.0 0.0005411255411255 0.0677946550734017 0.0 84 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1125625 MMRN2 CD93 MMRN2-CD93 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0030906201917869 0.7205550478301406 0.7461459456652184 0.7204611100467462 0.0002165306714062 0.0010390313650636 0.0 0.0 0.0 0.0 43 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125638 MMRN2 CD93 MMRN2-CD93 Plasma Cells Luminal-like Amorphous DCIS Cells Plasma Cells -> Luminal-like Amorphous DCIS Cells 0.0030897473428895 0.7205550478301406 0.4630027772793905 0.2461374514707439 0.0002165306714062 0.0048929293424311 0.0 0.0 0.0 0.0 271 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125668 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0030878833631116 0.940547666092272 0.9003264838243337 1.0 0.0001298888146421 0.0007880862995141 0.0 0.0 0.0 0.0 4019 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125694 VWF LRP1 VWF-LRP1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0030863694748223 0.2486570577556728 0.9078204025796472 0.2461374514707439 0.0001077515101466 0.0144359394371152 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1125761 MMRN2 CLEC14A MMRN2-CLEC14A B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0030806191346601 0.6301823358791634 0.9003264838243337 0.6198216015396206 0.0003083910058032 0.0007880862995141 0.0 0.0 0.0 0.0 800 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125788 THBS2 CD36 THBS2-CD36 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0030788992015715 0.8581959463413404 0.8765901449012573 1.0 0.0002636300075004 0.0004295051170816 0.0 0.0 0.0 0.0 14 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1125807 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0030774622600885 0.9197297916541942 0.2562573700401372 0.2461374514707439 0.0055862851962672 0.0002621208738319 0.0 0.0 0.0 0.0 29 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1125838 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) B Cells 11q13 Invasive Tumor Cells (Mitotic) -> B Cells 0.0030759483528213 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.000393370777602 0.0007053434767499 0.0 0.0 0.0 0.0 42 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1125857 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.003074572743808 0.7797135509308979 0.252518874138558 0.2461374514707439 0.0009209869688402 0.0018925243453249 0.0 0.0027777777777777 0.1538719785138766 0.0 24 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1125931 VWF LRP1 VWF-LRP1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0030684990094447 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0001077515101466 0.0203874717835032 0.0 0.0001329080276448 0.0062231217210202 0.0 684 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1125941 VWF SELP VWF-SELP Basal-like Structured DCIS Cells CXCL14+ Fibroblasts Basal-like Structured DCIS Cells -> CXCL14+ Fibroblasts 0.0030679766951526 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0020251995753771 0.0001189339410417 0.0 0.0 0.0 0.0 1109 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1125949 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0030671970325183 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.000716220684292 0.0003375370073613 0.0 0.0 0.0 0.0 380 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125979 MMRN2 CD93 MMRN2-CD93 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0030646366506194 0.250044481781731 0.6587114738285964 0.2461374514707439 7.058774627838557e-05 0.0289462771086338 0.0 0.0 0.0 0.0 184 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1125981 MMRN2 CLEC14A MMRN2-CLEC14A B Cells B Cells B Cells -> B Cells 0.0030643000449161 0.6301823358791634 0.6347970925105053 1.0 0.0003083910058032 0.000671064546954 0.0 0.0003526093088857 0.1169481839807567 0.0 1418 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1126009 C3 LRP1 C3-LRP1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0030622443076315 0.2485046029682279 0.6207977546603366 0.2461374514707439 0.0013028322726017 0.0016667952436519 0.0 0.0 0.0 0.0 11 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1126023 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0030613412367768 0.2542249848376565 0.8617632615906476 0.2461374514707439 0.0014656941948563 0.0010414441948928 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1126032 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.0030607398190749 0.2485046029682279 0.8755243548400705 0.2461374514707439 0.0036991419150414 0.0004150165744076 0.0 0.0 0.0 0.0 34 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1126040 DLL4 NOTCH3 DLL4-NOTCH3 B Cells B Cells B Cells -> B Cells 0.00306009524439 0.6342079770588467 0.7746834992804791 1.0 0.0002327631000826 0.00071798405859 0.0 0.0 0.0 0.0 1418 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1126065 VWF SELP VWF-SELP Dendritic Cells CXCL14+ Fibroblasts Dendritic Cells -> CXCL14+ Fibroblasts 0.0030583030811891 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0019871862905238 0.0001189339410417 0.0 0.0 0.0 0.0 922 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1126066 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0030582167696231 0.940547666092272 0.2491545808994955 0.2461374514707439 0.0001298888146421 0.0109188419829382 0.0 0.0001117818019226 0.0160913485872288 0.0 1491 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1126067 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0030581938904645 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0002705513462707 0.0008609682710384 0.0 0.0 0.0 0.0 306 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1126115 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Plasma Cells B Cells -> Plasma Cells 0.0030552126535509 0.6301823358791634 0.7154802332407408 0.6198216015396206 0.0003083910058032 0.0009436211854823 0.0 0.0 0.0 0.0 297 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1126116 VWF SELP VWF-SELP B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0030551929753128 0.6332974881236617 0.6572093097629401 0.7917001487310438 0.00023686843287 0.0010419094417808 0.0 0.0 0.0 0.0 42 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1126127 MMRN2 CD93 MMRN2-CD93 Plasma Cells B Cells Plasma Cells -> B Cells 0.0030546489818484 0.7205550478301406 0.7779918296243433 0.6198216015396206 0.0002165306714062 0.001079730675535 0.0 0.0 0.0 0.0 315 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1126215 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0030475772054956 0.255669001367946 0.4596166826058663 0.3990376746076917 0.0002269856810233 0.0075270071967493 0.0 0.0 0.0 0.0 89 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1126216 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0030475633768519 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0104129581710415 0.0001990509171164 0.0 0.0001801152737752 0.1208663604533181 0.0 694 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126243 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0030453187252172 0.7205550478301406 0.9003264838243337 0.7204611100467462 0.0002165306714062 0.0007880862995141 0.0 0.0005446623093681 0.3637022845678102 0.0 306 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1126260 VWF ITGA9 VWF-ITGA9 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0030441519410937 0.7848266128497919 0.2531744428854943 0.2461374514707439 0.0004024409845247 0.0040430820937484 0.0 0.0 0.0 0.0 24 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1126362 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Myeloid Cells Luminal-like Amorphous DCIS Cells -> Myeloid Cells 0.003036379057551 0.2510234128936706 0.7763054211764489 0.2461374514707439 0.0009262556366009 0.0017638974017382 0.0 0.0 0.0 0.0 84 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126367 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0030359243023079 0.250044481781731 0.2491545808994955 0.3990376746076917 0.0070431301838115 0.0004471667362236 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1126381 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Mast Cells Macrophages -> Mast Cells 0.0030346663697317 0.6303682835571691 0.773263018678637 0.8567148457705164 0.0002750231449378 0.0006800116997025 0.0 0.0 0.0 0.0 165 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1126444 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages B Cells Macrophages -> B Cells 0.0030308883007751 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0002750231449378 0.0008542071298387 0.0 6.65070497472732e-05 0.0122834836597762 0.0 1074 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1126486 VWF LRP1 VWF-LRP1 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0030275610512928 0.7158082793127664 0.7769451595923457 0.7204611100467462 0.0003457348439318 0.0005558995075445 0.0 0.0 0.0 0.0 43 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126503 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0030264860913636 0.9275752708651288 0.7769451595923457 0.7827641335561659 0.000245041593909 0.0005558995075445 0.0 2.1603871413757345e-05 0.0027066307158582 0.0 526 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126518 C3 LRP1 C3-LRP1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0030252302128971 0.7148920381722296 0.2550748532138862 0.2461374514707439 0.005043231651446 0.0003386430177035 0.0 0.0003574833174451 0.0370529026935196 0.0 1049 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1126550 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells B Cells Plasma Cells -> B Cells 0.003022618833578 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.0002705513462707 0.0008542071298387 0.0 0.000453514739229 0.0837616600038073 0.0 315 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1126563 VWF SELP VWF-SELP Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0030218057594913 0.8525936146535493 0.6572093097629401 0.6198216015396206 0.0002103933337194 0.0010419094417808 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1126579 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0030205513141237 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0018436902762588 0.0001189339410417 0.0 0.0 0.0 0.0 380 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1126588 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0030199651828124 0.255669001367946 0.6632137581773894 0.2461374514707439 0.0002269856810233 0.0080072638027924 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1126653 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0030153589412653 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0097699360831605 0.0001990509171164 0.0 0.0001396648044692 0.0937220716811204 0.0 179 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126697 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.003011458207351 0.2486570577556728 0.8755243548400705 0.2461374514707439 0.0033537993821664 0.0004150165744076 0.0 0.0 0.0 0.0 34 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126714 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) -> Luminal-like Amorphous DCIS Cells 0.0030102726827922 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0001959417442809 0.0096442330625583 0.0 0.0 0.0 0.0 19 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126729 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0030094592634361 0.6242573126045354 0.8587566561291643 0.6198216015396206 0.0001959417442809 0.0011409783203169 0.0 0.0 0.0 0.0 380 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126734 VWF SELP VWF-SELP Macrophages CXCL14+ Fibroblasts Macrophages -> CXCL14+ Fibroblasts 0.0030091710131715 0.9011206516381156 0.8819126042133903 0.8875000050982297 0.0008850282134344 0.0001189339410417 0.0 0.0 0.0 0.0 1462 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1126743 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0030084693561247 0.940547666092272 0.7461459456652184 0.7827641335561659 0.0001298888146421 0.0010390313650636 0.0 0.0 0.0 0.0 526 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1126799 MMRN2 CD93 MMRN2-CD93 B Cells 11q13 Invasive Tumor Cells (G1/S) B Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0030047426016425 0.6301823358791634 0.6587114738285964 0.7917001487310438 0.0003083910058032 0.0007261054236978 0.0 0.0 0.0 0.0 42 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1126863 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0030006869577678 0.2486570577556728 0.7760344326192508 0.2461374514707439 0.0033537993821664 0.0004582650848664 0.0 0.0 0.0 0.0 176 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1126874 VWF LRP1 VWF-LRP1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0029999364185815 0.2486570577556728 0.2550748532138862 0.3990376746076917 0.0001077515101466 0.0267255153180908 0.0 0.0 0.0 0.0 89 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1126996 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0029908010322766 0.6160088550075702 0.7757991160529997 0.6198216015396206 0.0001971810371238 0.0012252690191386 0.0 0.0 0.0 0.0 380 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1127039 COL4A1 CD93 COL4A1-CD93 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0029876737068973 0.7766289238087107 0.4630027772793905 0.7204611100467462 0.0002970267018348 0.0009242223287825 0.0 0.0 0.0 0.0 50 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1127069 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0029855689842706 0.8937519114898692 0.2550748532138862 0.2461374514707439 0.0037268694422441 0.0003386430177035 0.0 0.0 0.0 0.0 29 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1127074 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0029851387568076 0.9275752708651288 0.8755243548400705 0.8567148457705164 0.000245041593909 0.0004150165744076 0.0 0.0 0.0 0.0 137 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1127120 VWF SELP VWF-SELP B Cells Mast Cells B Cells -> Mast Cells 0.0029810578759003 0.6332974881236617 0.8347297932672282 0.6198216015396206 0.00023686843287 0.0009042150166242 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1127146 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0029791706848696 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0002165306714062 0.0011388334136451 0.0 0.0 0.0 0.0 8 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1127158 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0029780696213662 0.2491449441646273 0.8819126042133903 0.2461374514707439 0.0108445362943651 0.0001189339410417 0.0 0.0 0.0 0.0 1384 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1127169 C1QB LRP1 C1QB-LRP1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0029772002286295 0.8703788833238396 0.2550748532138862 0.2461374514707439 0.0037630364713574 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1127170 VWF SELP VWF-SELP Myeloid Cells B Cells Myeloid Cells -> B Cells 0.0029771001631625 0.7848266128497919 0.7760344326192508 0.6198216015396206 0.0004024409845247 0.0004582650848664 0.0 0.0006313131313131 0.3175102580483508 0.0 144 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1127179 DLL4 NOTCH4 DLL4-NOTCH4 B Cells B Cells B Cells -> B Cells 0.002976459834367 0.6342079770588467 0.7754072541855492 1.0 0.0002327631000826 0.0006074333625108 0.0 0.0 0.0 0.0 1418 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1127197 CD34 SELP CD34-SELP Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.002975191626451 0.2491449441646273 0.6572093097629401 0.2461374514707439 0.0003767662344862 0.0045674276780054 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1127210 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.0029746520483822 0.6319926036888139 0.7769451595923457 0.6198216015396206 0.0004094805141934 0.0005558995075445 0.0 0.0 0.0 0.0 21 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1127224 JAG1 NOTCH2 JAG1-NOTCH2 B Cells B Cells B Cells -> B Cells 0.002972995393867 0.8630183004227985 0.8445107771175474 1.0 0.0001109003117737 0.0008542071298387 0.0 6.716367788300087e-05 0.0124047592389277 0.0 1418 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1127304 COL4A1 CD93 COL4A1-CD93 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0029682368242509 0.7766289238087107 0.6587114738285964 0.6198216015396206 0.0002970267018348 0.0007261054236978 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1127316 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts -> Luminal-like Amorphous DCIS Cells 0.0029663304247936 0.940547666092272 0.4630027772793905 0.2461374514707439 0.0001298888146421 0.0048929293424311 0.0 0.0005030181086519 0.1034508224703467 0.0 1491 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1127353 VWF SELP VWF-SELP Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0029637527773416 0.2486570577556728 0.4623922682986163 0.2461374514707439 0.0001077515101466 0.0222228052993653 0.0 0.0 0.0 0.0 89 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1127444 MMRN2 CD93 MMRN2-CD93 Plasma Cells Plasma Cells Plasma Cells -> Plasma Cells 0.0029563912115471 0.7205550478301406 0.4630027772793905 1.0 0.0002165306714062 0.0009242223287825 0.0 0.0 0.0 0.0 283 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1127467 VWF SELP VWF-SELP CAFs, Invasive Associated CXCL14+ Fibroblasts CAFs, Invasive Associated -> CXCL14+ Fibroblasts 0.0029550514540035 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0016171311116606 0.0001189339410417 0.0 0.0 0.0 0.0 1490 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1127547 THBS2 CD36 THBS2-CD36 Mast Cells 11q13 Invasive Tumor Cells (G1/S) Mast Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0029493457106878 0.8581959463413404 0.6176321640000088 0.6198216015396206 0.0002636300075004 0.0007598956708367 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1127552 CD34 SELP CD34-SELP Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0029492800084977 0.2491449441646273 0.7760344326192508 0.2461374514707439 0.0003767662344862 0.0036702914086929 0.0 0.0 0.0 0.0 684 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1127588 THBS2 CD36 THBS2-CD36 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0029463876512175 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0063387366560491 0.0002621208738319 0.0 0.0 0.0 0.0 86 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1127608 VWF LRP1 VWF-LRP1 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0029445785267782 0.8525936146535493 0.8755243548400705 1.0 0.0002103933337194 0.0004150165744076 0.0 0.0 0.0 0.0 14 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1127632 VWF LRP1 VWF-LRP1 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0029416061248604 0.7158082793127664 0.8755243548400705 0.7204611100467462 0.0003457348439318 0.0004150165744076 0.0 0.0004734848484848 0.057931162330841 0.0 48 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1127645 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0029402670683387 0.6303682835571691 0.773263018678637 0.7204611100467462 0.0002705513462707 0.0006800116997025 0.0 0.0014880952380952 0.1278580024067389 0.0 48 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1127677 CD34 SELP CD34-SELP Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.002937413404981 0.8532069650852002 0.8819126042133903 0.8567148457705164 0.00083777361258 0.0001189339410417 0.0 0.0 0.0 0.0 148 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1127691 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (Mitotic) -> CXCL14+ Fibroblasts 0.0029365251587893 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0015572459193676 0.0001189339410417 0.0 0.0 0.0 0.0 339 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1127704 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0029353104227139 0.2451358214448441 0.4614667734221426 0.2461374514707439 0.0010709508378277 0.0021449819680126 0.0 0.0047619047619047 0.1728187919463087 0.0 15 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1127736 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0029326340332566 0.940547666092272 0.7779918296243433 0.6198216015396206 0.0001298888146421 0.001079730675535 0.0 0.0 0.0 0.0 791 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1127808 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0029265102128012 0.8516956437178343 0.8341464445360613 1.0 0.000472352586488 0.0001871866311057 0.0 0.0 0.0 0.0 14 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1127813 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.002926342124863 0.6332974881236617 0.7760344326192508 0.7917001487310438 0.0003521782369754 0.0004582650848664 0.0 0.0 0.0 0.0 38 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1127859 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0029230498631978 0.6303682835571691 0.773263018678637 0.8567148457705164 0.000219642761279 0.0006800116997025 0.0 0.0 0.0 0.0 137 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1127862 VWF ITGA9 VWF-ITGA9 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0029228774797896 0.7158082793127664 0.2531744428854943 0.2461374514707439 0.0003457348439318 0.0040430820937484 0.0 0.0 0.0 0.0 24 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1127900 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0029194107534568 0.6303682835571691 0.8445107771175474 0.6198216015396206 0.000219642761279 0.0008542071298387 0.0 0.0 0.0 0.0 791 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1127973 THBS2 CD36 THBS2-CD36 Mast Cells B Cells Mast Cells -> B Cells 0.0029129533938729 0.8581959463413404 0.6176321640000088 0.6198216015396206 0.0002636300075004 0.0007053434767499 0.0 0.0 0.0 0.0 112 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1127996 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0029110197294105 0.255669001367946 0.6632137581773894 0.2461374514707439 0.0002269856810233 0.0064230792457803 0.0 0.0 0.0 0.0 2 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1128017 VWF LRP1 VWF-LRP1 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0029093994268808 0.8525936146535493 0.7769451595923457 0.7827641335561659 0.0002103933337194 0.0005558995075445 0.0 0.0 0.0 0.0 23 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128074 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0029051023255661 0.2490567623945399 0.7754072541855492 0.2461374514707439 0.000126812416921 0.009971631136135 0.0 0.0 0.0 0.0 64 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1128082 THBS2 CD36 THBS2-CD36 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0029043926191401 0.9197297916541942 0.2562573700401372 0.2461374514707439 0.0039472834455595 0.0002621208738319 0.0 0.0 0.0 0.0 33 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128101 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.00290245565023 0.8913986641324685 0.2491073778594529 0.2461374514707439 0.0054950348959687 0.0001990509171164 0.0 0.0 0.0 0.0 19 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1128112 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Myeloid Cells 11q13 Invasive Tumor Cells (G1/S) -> Myeloid Cells 0.002901843373248 0.6332974881236617 0.7769451595923457 0.6198216015396206 0.0003521782369754 0.0005558995075445 0.0 0.0 0.0 0.0 21 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128147 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0028995643209758 0.940547666092272 0.7154802332407408 0.7204611100467462 0.0001298888146421 0.0009436211854823 0.0 0.0 0.0 0.0 285 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1128207 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Mast Cells B Cells -> Mast Cells 0.0028950998255778 0.6301823358791634 0.8514619504364779 0.6198216015396206 0.0003083910058032 0.0005740632036187 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1128211 COL4A1 CD93 COL4A1-CD93 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0028945920169664 0.7766289238087107 0.8817184225858201 0.8567148457705164 0.0002970267018348 0.0003375370073613 0.0 0.0 0.0 0.0 148 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1128222 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Plasma Cells B Cells -> Plasma Cells 0.0028938152070052 0.8630183004227985 0.4614667734221426 0.6198216015396206 0.0001109003117737 0.0021449819680126 0.0 0.0001603334936668 0.0058188145436467 0.0 297 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1128257 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0028901992516758 0.6319926036888139 0.8755243548400705 0.6198216015396206 0.0004094805141934 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1128307 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0028853853749139 0.9184503888425788 0.8341464445360613 0.8567148457705164 0.0004696576149175 0.0001871866311057 0.0 0.0 0.0 0.0 137 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1128312 THBS2 CD36 THBS2-CD36 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0028849059383088 0.2510234128936706 0.6176321640000088 0.2461374514707439 5.260070730345377e-05 0.02871400543887 0.0 0.0 0.0 0.0 184 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128326 CD34 SELP CD34-SELP Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0028838246154192 0.2491449441646273 0.7760344326192508 0.2461374514707439 0.0003767662344862 0.0032078747392388 0.0 0.0 0.0 0.0 64 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1128340 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) 11q13 Invasive Tumor Cells (G1/S) -> 11q13 Invasive Tumor Cells (G1/S) 0.0028829275609858 0.6242573126045354 0.6176321640000088 1.0 0.0001959417442809 0.0007598956708367 0.0 2.2571325388226794e-05 0.0106168305319544 0.0 1846 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128347 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Mast Cells 11q13 Invasive Tumor Cells (Mitotic) -> Mast Cells 0.0028820604752945 0.6242573126045354 0.8765901449012573 0.6198216015396206 0.000393370777602 0.0004295051170816 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128355 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0028817280127435 0.9275752708651288 0.2531744428854943 0.2461374514707439 0.000245041593909 0.0040430820937484 0.0 0.0 0.0 0.0 29 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1128373 THBS2 CD36 THBS2-CD36 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.00287974057168 0.2510234128936706 0.6176321640000088 0.2461374514707439 5.260070730345377e-05 0.0284069116891947 0.0 0.0 0.0 0.0 64 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128385 C3 LRP1 C3-LRP1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0028789728375045 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0042375227960614 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1128395 CD34 SELP CD34-SELP Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0028782259413751 0.2491449441646273 0.4623922682986163 0.2461374514707439 0.0003767662344862 0.0053213839468185 0.0 0.0 0.0 0.0 937 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1128456 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.002872647307914 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.0003521782369754 0.0040430820937484 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1128470 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0028716387571952 0.2510234128936706 0.8587566561291643 0.2461374514707439 0.0009262556366009 0.0011409783203169 0.0 3.010597302504817e-05 0.023004346753308 0.0 1384 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128505 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0028684113780472 0.6626993710110988 0.2550748532138862 0.2461374514707439 0.0039530346951707 0.0003386430177035 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1128563 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0028640241955859 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0031934983073077 0.0004471667362236 0.0 0.0 0.0 0.0 86 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1128593 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0028623003448706 0.6342079770588467 0.8341464445360613 0.6198216015396206 0.000895875398841 0.0001871866311057 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1128598 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Mast Cells Plasma Cells -> Mast Cells 0.0028619252574946 0.7205550478301406 0.8514619504364779 0.7204611100467462 0.0002165306714062 0.0005740632036187 0.0 0.0 0.0 0.0 48 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1128623 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0028601706425994 0.940547666092272 0.6347970925105053 0.6198216015396206 0.0001298888146421 0.0011388334136451 0.0 0.0 0.0 0.0 409 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1128639 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Plasma Cells 11q13 Invasive Tumor Cells (G1/S) -> Plasma Cells 0.0028587051049541 0.6242573126045354 0.7373999388878224 0.6198216015396206 0.0001959417442809 0.0009761781830445 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1128642 VWF SELP VWF-SELP Plasma Cells B Cells Plasma Cells -> B Cells 0.0028584969444263 0.7158082793127664 0.7760344326192508 0.6198216015396206 0.0003457348439318 0.0004582650848664 0.0 0.0 0.0 0.0 315 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1128655 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0028577876895922 0.2490567623945399 0.7746834992804791 0.2461374514707439 0.000126812416921 0.0090444648829713 0.0 0.0 0.0 0.0 64 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1128770 VWF SELP VWF-SELP B Cells B Cells B Cells -> B Cells 0.0028478913962456 0.6332974881236617 0.7760344326192508 1.0 0.00023686843287 0.0004582650848664 0.0 0.0 0.0 0.0 1418 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1128838 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0028424058320626 0.6342079770588467 0.7470475610360806 0.6198216015396206 0.0002327631000826 0.0007714919761827 0.0 0.0 0.0 0.0 137 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1128884 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Myeloid Cells Macrophages -> Myeloid Cells 0.0028380295599225 0.6303682835571691 0.7426180951053148 0.7827641335561659 0.0002750231449378 0.0005184623914895 0.0 0.0 0.0 0.0 179 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1128967 MMRN2 CD93 MMRN2-CD93 B Cells Plasma Cells B Cells -> Plasma Cells 0.0028316239854288 0.6301823358791634 0.4630027772793905 0.6198216015396206 0.0003083910058032 0.0009242223287825 0.0 0.0 0.0 0.0 297 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1128981 THBS2 CD36 THBS2-CD36 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0028304424277107 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.004981832968137 0.0002621208738319 0.0 0.0 0.0 0.0 75 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129003 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Mast Cells CXCL14+ Fibroblasts -> Mast Cells 0.0028280850829449 0.940547666092272 0.8514619504364779 0.8567148457705164 0.0001298888146421 0.0005740632036187 0.0 0.0 0.0 0.0 137 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1129102 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.0028194576741852 0.6332974881236617 0.8755243548400705 0.6198216015396206 0.0003521782369754 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129109 VWF SELP VWF-SELP CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0028182538529422 0.9275752708651288 0.7760344326192508 0.6198216015396206 0.000245041593909 0.0004582650848664 0.0 0.0001723939777037 0.0867031804531526 0.0 791 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1129150 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0028133568732986 0.6626993710110988 0.2550748532138862 0.2461374514707439 0.0035190936623492 0.0003386430177035 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1129155 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0028131707945515 0.8818165186409654 0.2550748532138862 0.2461374514707439 0.0026436039558049 0.0003386430177035 0.0 0.0004789272030651 0.0682622096270401 0.0 29 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129188 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0028100713331775 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0002269856810233 0.0044430418127202 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1129190 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0028099831514622 0.2534163760166434 0.8341464445360613 0.2461374514707439 0.0050543892975134 0.0001871866311057 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1129256 VWF LRP1 VWF-LRP1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0028046303148665 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0036144684673052 0.0003386430177035 0.0 0.0 0.0 0.0 86 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129353 VWF SELP VWF-SELP Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0027966519123648 0.2486570577556728 0.4623922682986163 0.3990376746076917 0.0001077515101466 0.0096770075292062 0.0 0.0 0.0 0.0 89 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1129384 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0027942699937555 0.6589792304505506 0.2550748532138862 0.2461374514707439 0.0033973231723341 0.0003386430177035 0.0 0.0 0.0 0.0 4 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129413 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Myeloid Cells Plasma Cells -> Myeloid Cells 0.0027914314778987 0.6303682835571691 0.7426180951053148 0.7204611100467462 0.0002705513462707 0.0005184623914895 0.0 0.0 0.0 0.0 43 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1129418 CD34 SELP CD34-SELP Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0027909663963297 0.2491449441646273 0.7478729882108823 0.2461374514707439 0.0003767662344862 0.0027351735586246 0.0 0.0 0.0 0.0 20 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1129483 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0027845515579523 0.2451358214448441 0.8445107771175474 0.2461374514707439 0.0010709508378277 0.0008542071298387 0.0 0.0 0.0 0.0 11 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1129489 VWF ITGA9 VWF-ITGA9 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0027840900836158 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0001077515101466 0.0112932915661816 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1129496 CD34 SELP CD34-SELP Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0027837654301802 0.2491449441646273 0.941479368642921 0.2461374514707439 0.0003767662344862 0.0021392900294222 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1129518 MMRN2 CD93 MMRN2-CD93 Plasma Cells 11q13 Invasive Tumor Cells (G1/S) Plasma Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0027809661988158 0.7205550478301406 0.6587114738285964 0.6198216015396206 0.0002165306714062 0.0007261054236978 0.0 0.0 0.0 0.0 8 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1129639 VWF ITGA9 VWF-ITGA9 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0027702416517384 0.8525936146535493 0.2531744428854943 0.2461374514707439 0.0002103933337194 0.0040430820937484 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1129680 THBS2 CD36 THBS2-CD36 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0027658415019079 0.8858959974474152 0.2562573700401372 0.2461374514707439 0.0030563796158022 0.0002621208738319 0.0 0.0 0.0 0.0 19 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129689 CCN1 CAV1 CCN1-CAV1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.002764507986297 0.8749036366850302 0.252518874138558 0.2461374514707439 0.0004337320404416 0.0018925243453249 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1129693 C3 LRP1 C3-LRP1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0027640400065538 0.7148920381722296 0.2550748532138862 0.2461374514707439 0.0029337538459309 0.0003386430177035 0.0 0.0 0.0 0.0 24 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1129701 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Plasma Cells Mast Cells -> Plasma Cells 0.0027632827700843 0.6303682835571691 0.4614667734221426 0.7204611100467462 9.902323108165852e-05 0.0021449819680126 0.0 0.0 0.0 0.0 50 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1129787 HSPG2 LRP1 HSPG2-LRP1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0027536812455286 0.9253089325030373 0.2550748532138862 0.2461374514707439 0.0022161183602947 0.0003386430177035 0.0 0.0 0.0 0.0 19 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129847 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0027475541273283 0.2451358214448441 0.773263018678637 0.2461374514707439 0.0010709508378277 0.0008609682710384 0.0 0.0035714285714285 1.0 0.0 20 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1129856 VWF LRP1 VWF-LRP1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0027459943404956 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0001077515101466 0.0104714078116759 0.0 0.0 0.0 0.0 74 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129892 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0027427940389408 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0024635726452692 0.0004471667362236 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1129928 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) B Cells 11q13 Invasive Tumor Cells (G1/S) -> B Cells 0.0027386405795187 0.6242573126045354 0.6176321640000088 0.7917001487310438 0.0001959417442809 0.0007053434767499 0.0 0.0 0.0 0.0 38 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1129975 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Myeloid Cells CXCL14+ Fibroblasts -> Myeloid Cells 0.0027336454509878 0.6303682835571691 0.7426180951053148 0.7827641335561659 0.000219642761279 0.0005184623914895 0.0 0.0001810610175629 0.0212987022608109 0.0 526 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1130025 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells B Cells Plasma Cells -> B Cells 0.0027278041007 0.7205550478301406 0.6347970925105053 0.6198216015396206 0.0002165306714062 0.000671064546954 0.0 0.001058201058201 0.3509683066343133 0.0 315 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1130026 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Plasma Cells Luminal-like Amorphous DCIS Cells -> Plasma Cells 0.0027277885015812 0.2510234128936706 0.7373999388878224 0.2461374514707439 0.0009262556366009 0.0009761781830445 0.0 0.0 0.0 0.0 272 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130122 VWF LRP1 VWF-LRP1 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0027162250295139 0.6332974881236617 0.7769451595923457 0.6198216015396206 0.00023686843287 0.0005558995075445 0.0 8.294625082946251e-05 0.010391881434609 0.0 137 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130144 DLL4 NOTCH4 DLL4-NOTCH4 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0027141479288842 0.6342079770588467 0.896164124004365 0.6198216015396206 0.0002327631000826 0.0004874986369898 0.0 0.0 0.0 0.0 800 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1130155 MMRN2 CD93 MMRN2-CD93 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0027132846151677 0.250044481781731 0.7779918296243433 0.2461374514707439 7.058774627838557e-05 0.0118035014556376 0.0 0.0 0.0 0.0 74 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1130202 VWF SELP VWF-SELP Mast Cells B Cells Mast Cells -> B Cells 0.0027092231376686 0.8525936146535493 0.7760344326192508 0.6198216015396206 0.0002103933337194 0.0004582650848664 0.0 0.0 0.0 0.0 112 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1130210 JAG1 NOTCH2 JAG1-NOTCH2 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.002708713141277 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0001109003117737 0.0008609682710384 0.0 0.0 0.0 0.0 800 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1130241 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Plasma Cells B Cells -> Plasma Cells 0.0027059295733869 0.6342079770588467 0.4638256179742202 0.6198216015396206 0.0002327631000826 0.0009249287638231 0.0 0.0 0.0 0.0 297 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1130336 VWF LRP1 VWF-LRP1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.002696461654352 0.7158082793127664 0.2550748532138862 0.2461374514707439 0.0025256125075084 0.0003386430177035 0.0 9.749545021232342e-05 0.0062815860539483 0.0 1049 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130343 VWF LRP1 VWF-LRP1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0026952758593224 0.2486570577556728 0.9078204025796472 0.2461374514707439 0.0001077515101466 0.0064028969591119 0.0 0.0 0.0 0.0 20 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130400 VWF ITGA9 VWF-ITGA9 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0026888965099409 0.6332974881236617 0.2531744428854943 0.2461374514707439 0.00023686843287 0.0040430820937484 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1130419 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Plasma Cells CXCL14+ Fibroblasts -> Plasma Cells 0.0026873664158946 0.940547666092272 0.4630027772793905 0.7204611100467462 0.0001298888146421 0.0009242223287825 0.0 0.0 0.0 0.0 285 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1130490 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0026799841081283 0.2490567623945399 0.8818120773736414 0.2461374514707439 0.000126812416921 0.0054043611446182 0.0 0.0 0.0 0.0 15 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1130492 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0026798447818584 0.7451589345683471 0.2491073778594529 0.2461374514707439 0.0040724665904272 0.0001990509171164 0.0 0.0 0.0 0.0 24 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1130522 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0026771481496716 0.255669001367946 0.6632137581773894 0.2461374514707439 0.0002269856810233 0.0038860320327025 0.0 0.0 0.0 0.0 4 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1130546 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0026743751463268 0.255669001367946 0.6631822525600675 0.2461374514707439 0.0002269856810233 0.0038621268649178 0.0 0.0 0.0 0.0 2 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1130567 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0026722377744572 0.2490567623945399 0.7480927101953669 0.2461374514707439 0.000126812416921 0.006260692484444 0.0 0.0 0.0 0.0 20 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1130575 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0026716221255448 0.940547666092272 0.8817184225858201 1.0 0.0001298888146421 0.0003375370073613 0.0 0.0 0.0 0.0 4019 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1130589 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts -> 11q13 Invasive Tumor Cells (G1/S) 0.0026698832397589 0.940547666092272 0.6587114738285964 0.6198216015396206 0.0001298888146421 0.0007261054236978 0.0 0.0 0.0 0.0 409 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1130618 MMRN2 CD93 MMRN2-CD93 B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0026653371493414 0.6301823358791634 0.8817184225858201 0.6198216015396206 0.0003083910058032 0.0003375370073613 0.0 0.0 0.0 0.0 800 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1130638 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0026630850252716 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0034559943126159 0.0002621208738319 0.0 0.0 0.0 0.0 179 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130646 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0026622888548518 0.6303682835571691 0.773263018678637 0.8567148457705164 9.902323108165852e-05 0.0008609682710384 0.0 0.0001608751608751 0.0482640736757491 0.0 148 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1130650 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0026619069609576 0.2490567623945399 0.6571792026963191 0.2461374514707439 0.000126812416921 0.0069630688870869 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1130735 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0026532598283763 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0001826541344284 0.0049190726392343 0.0 0.0 0.0 0.0 11 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130781 C3 LRP1 C3-LRP1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0026472792021012 0.2485046029682279 0.7769451595923457 0.2461374514707439 0.0013028322726017 0.0005558995075445 0.0 0.0025 0.5604605874441559 0.0 20 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1130782 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.002647171589489 0.2491408586098361 0.2491073778594529 0.3990376746076917 0.0001826541344284 0.0076066460958003 0.0 0.0 0.0 0.0 89 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130783 VWF ITGA9 VWF-ITGA9 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0026471454455315 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0001077515101466 0.0083442542366581 0.0 0.0 0.0 0.0 11 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1130796 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0026445802084324 0.255669001367946 0.7447682696221608 0.2461374514707439 0.0002269856810233 0.0032154705418133 0.0 0.0 0.0 0.0 20 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1130830 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0026416058655569 0.2451358214448441 0.773263018678637 0.2461374514707439 0.0010709508378277 0.0006800116997025 0.0 0.0 0.0 0.0 1 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1130860 VWF LRP1 VWF-LRP1 B Cells Mast Cells B Cells -> Mast Cells 0.0026391091865531 0.6332974881236617 0.8755243548400705 0.6198216015396206 0.00023686843287 0.0004150165744076 0.0 0.0001171508903467 0.0143334834633008 0.0 97 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130897 MMRN2 CD93 MMRN2-CD93 Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.0026347954015425 0.7205550478301406 0.8817184225858201 0.7204611100467462 0.0002165306714062 0.0003375370073613 0.0 0.0 0.0 0.0 306 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1130918 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0026326223857708 0.724503440376099 0.2562573700401372 0.2461374514707439 0.0027791828709671 0.0002621208738319 0.0 0.0 0.0 0.0 1049 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1130975 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Mast Cells Mast Cells -> Mast Cells 0.0026264605896897 0.6303682835571691 0.773263018678637 1.0 9.902323108165852e-05 0.0006800116997025 0.0 0.0 0.0 0.0 14 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1131040 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts B Cells CXCL14+ Fibroblasts -> B Cells 0.0026188446493545 0.940547666092272 0.6347970925105053 0.6198216015396206 0.0001298888146421 0.000671064546954 0.0 0.0 0.0 0.0 791 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1131066 CD34 SELP CD34-SELP Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0026165295945592 0.2491449441646273 0.6572093097629401 0.2461374514707439 0.0003767662344862 0.002113171886167 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1131107 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0026110319795329 0.2485046029682279 0.2550748532138862 0.3990376746076917 0.0036991419150414 0.0003386430177035 0.0 0.0 0.0 0.0 97 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1131143 MMRN2 CD93 MMRN2-CD93 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0026063958101179 0.250044481781731 0.4630027772793905 0.2461374514707439 7.058774627838557e-05 0.0155837683010033 0.0 0.0 0.0 0.0 89 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1131163 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Mast Cells B Cells -> Mast Cells 0.0026042626243241 0.8630183004227985 0.773263018678637 0.6198216015396206 0.0001109003117737 0.0006800116997025 0.0 0.0019636720667648 0.1687198382274492 0.0 97 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1131343 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0025797125533432 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0001826541344284 0.0041555861088636 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131370 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0025763562786544 0.2490567623945399 0.8818326005152037 0.2461374514707439 0.000126812416921 0.0042655619249233 0.0 0.0 0.0 0.0 20 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1131396 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0025727040259807 0.4619393085577573 0.2491073778594529 0.2461374514707439 0.0051428381563772 0.0001990509171164 0.0 0.0 0.0 0.0 24 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1131399 C3 LRP1 C3-LRP1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0025721207873879 0.2485046029682279 0.8755243548400705 0.2461374514707439 0.0013028322726017 0.0004150165744076 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1131429 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0025689912077521 0.2486570577556728 0.2550748532138862 0.3990376746076917 0.0033537993821664 0.0003386430177035 0.0 0.0 0.0 0.0 97 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131438 VWF ITGA9 VWF-ITGA9 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0025679058650041 0.2486570577556728 0.7831795333113832 0.2461374514707439 0.0001077515101466 0.0055509879377996 0.0 0.0 0.0 0.0 20 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1131449 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Mast Cells 11q13 Invasive Tumor Cells (G1/S) -> Mast Cells 0.002566014401064 0.6242573126045354 0.8765901449012573 0.6198216015396206 0.0001959417442809 0.0004295051170816 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131476 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0025612766608529 0.8640667164982425 0.2491073778594529 0.2461374514707439 0.002676946692949 0.0001990509171164 0.0 0.0 0.0 0.0 29 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1131508 C3 LRP1 C3-LRP1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0025572596071007 0.2485046029682279 0.2550748532138862 1.0 0.0013028322726017 0.0003386430177035 0.0 0.0004036326942482 0.0418362542084112 0.0 991 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1131516 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells B Cells Mast Cells -> B Cells 0.0025564418408808 0.6303682835571691 0.8445107771175474 0.6198216015396206 9.902323108165852e-05 0.0008542071298387 0.0 0.0002125850340136 0.0392632781267847 0.0 112 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1131525 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0025556774458625 0.2490567623945399 0.7746834992804791 0.2461374514707439 0.000126812416921 0.0046263543438723 0.0 0.0 0.0 0.0 74 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1131580 VWF ITGA9 VWF-ITGA9 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0025489794403132 0.2486570577556728 0.2531744428854943 1.0 0.0001077515101466 0.0040430820937484 0.0 0.0002752041097147 0.7389083432389889 0.0 991 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1131601 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.00254651562725 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0020251995753771 0.0003386430177035 0.0 4.912234739324076e-05 0.0031649297649336 0.0 694 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131654 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells 11q13 Invasive Tumor Cells (G1/S) Luminal-like Amorphous DCIS Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0025401119187621 0.2510234128936706 0.6176321640000088 0.2461374514707439 0.0009262556366009 0.0007598956708367 0.0 0.0 0.0 0.0 26 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131671 VWF LRP1 VWF-LRP1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0025384862282103 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0019871862905238 0.0003386430177035 0.0 0.0 0.0 0.0 75 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131684 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.002536485873125 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0015409900107563 0.0004471667362236 0.0 0.0 0.0 0.0 75 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1131710 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0025322380172939 0.255669001367946 0.6631822525600675 0.2461374514707439 0.0002269856810233 0.0027830389352876 0.0 0.0 0.0 0.0 4 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1131711 C1QB LRP1 C1QB-LRP1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0025322114350621 0.4601010570874773 0.2550748532138862 0.2461374514707439 0.0026949121497638 0.0003386430177035 0.0 0.0 0.0 0.0 24 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1131721 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0025309379313638 0.8349903778527206 0.2550748532138862 0.2461374514707439 0.0014804857410621 0.0003386430177035 0.0 0.0 0.0 0.0 3 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131743 CD34 SELP CD34-SELP B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0025280435942044 0.633566764858408 0.8819126042133903 0.6198216015396206 0.0006336851232098 0.0001189339410417 0.0 0.0 0.0 0.0 800 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1131762 VWF SELP VWF-SELP Myeloid Cells CXCL14+ Fibroblasts Myeloid Cells -> CXCL14+ Fibroblasts 0.0025253074143677 0.7848266128497919 0.8819126042133903 0.7827641335561659 0.0004024409845247 0.0001189339410417 0.0 0.0 0.0 0.0 527 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1131772 VWF ITGA9 VWF-ITGA9 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0025237644783547 0.2486570577556728 0.7292496872084557 0.2461374514707439 0.0001077515101466 0.0053724660607752 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1131777 A2M LRP1 A2M-LRP1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0025227353425229 0.7741139100414175 0.2550748532138862 0.2461374514707439 0.0015661096645571 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1131829 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0025163110861321 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.00146889578236 0.0004471667362236 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1131893 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells B Cells Luminal-like Amorphous DCIS Cells -> B Cells 0.0025087691848947 0.2510234128936706 0.6176321640000088 0.2461374514707439 0.0009262556366009 0.0007053434767499 0.0 0.0 0.0 0.0 176 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131902 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0025078884311973 0.2451358214448441 0.7426180951053148 0.2461374514707439 0.0010709508378277 0.0005184623914895 0.0 0.0095238095238095 1.0 0.0 20 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1131935 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0025038889477073 0.2491408586098361 0.2491073778594529 0.3990376746076917 0.0049987108499989 0.0001990509171164 0.0 0.0 0.0 0.0 97 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1131999 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0024943172008801 0.255669001367946 0.7462743270426613 0.2461374514707439 0.0002269856810233 0.0022591041672132 0.0 0.0 0.0 0.0 20 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1132003 CD34 SELP CD34-SELP Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0024938355809986 0.2491449441646273 0.4623922682986163 0.2461374514707439 0.0003767662344862 0.0022515473538965 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1132031 VWF SELP VWF-SELP CXCL14+ Fibroblasts CXCL14+ Fibroblasts CXCL14+ Fibroblasts -> CXCL14+ Fibroblasts 0.0024901705742301 0.9275752708651288 0.8819126042133903 1.0 0.000245041593909 0.0001189339410417 0.0 1.1309914270849828e-05 0.0711055872235514 0.0 4019 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1132139 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Myeloid Cells B Cells -> Myeloid Cells 0.0024724354955826 0.8630183004227985 0.7426180951053148 0.6198216015396206 0.0001109003117737 0.0005184623914895 0.0 0.0 0.0 0.0 137 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1132141 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0024721807498088 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0001826541344284 0.0032187363284526 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132263 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0024569047572512 0.250044481781731 0.6347970925105053 0.2461374514707439 7.058774627838557e-05 0.0079745943515326 0.0 0.0 0.0 0.0 74 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1132289 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0024527841814566 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0016171311116606 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132312 A2M LRP1 A2M-LRP1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0024503973898013 0.4648000335061383 0.2550748532138862 0.2461374514707439 0.0021905373114471 0.0003386430177035 0.0 0.0 0.0 0.0 24 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1132324 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Mast Cells Luminal-like Amorphous DCIS Cells -> Mast Cells 0.002448501794041 0.2510234128936706 0.8765901449012573 0.2461374514707439 0.0009262556366009 0.0004295051170816 0.0 0.0 0.0 0.0 34 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132327 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells CXCL14+ Fibroblasts Luminal-like Amorphous DCIS Cells -> CXCL14+ Fibroblasts 0.0024482032108884 0.2486570577556728 0.8819126042133903 0.2461374514707439 0.0033537993821664 0.0001189339410417 0.0 0.0 0.0 0.0 1384 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1132346 HSPG2 LRP1 HSPG2-LRP1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.002446320596207 0.7789175740361626 0.2550748532138862 0.2461374514707439 0.0012941512528773 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132361 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0024445217018764 0.718867305289982 0.2491073778594529 0.2461374514707439 0.0024319941937022 0.0001990509171164 0.0 0.0 0.0 0.0 24 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132372 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0024430559183837 0.2491408586098361 0.7167436199046466 0.2461374514707439 0.0001826541344284 0.0026482500471321 0.0 8.0042689434365e-05 0.0731032723973624 0.0 937 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132395 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0024409101663421 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0020491452254277 0.0002621208738319 0.0 0.0 0.0 0.0 694 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132413 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0024385426680267 0.250044481781731 0.6347970925105053 0.2461374514707439 7.058774627838557e-05 0.0076236123034427 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1132421 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.002437406782941 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0015572459193676 0.0003386430177035 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132507 C1QB LRP1 C1QB-LRP1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0024209799159435 0.7753420160918723 0.2550748532138862 0.2461374514707439 0.0012213774841743 0.0003386430177035 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1132548 VWF SELP VWF-SELP Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0024141806033987 0.2486570577556728 0.6572093097629401 0.2461374514707439 0.0001077515101466 0.0045674276780054 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1132588 VWF ITGA9 VWF-ITGA9 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0024079646879795 0.2486570577556728 0.6252253442669611 0.2461374514707439 0.0001077515101466 0.0047273851759697 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1132607 C1QB LRP1 C1QB-LRP1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0024045978739822 0.7452691992612583 0.2550748532138862 0.2461374514707439 0.0012199377895337 0.0003386430177035 0.0 0.0 0.0 0.0 24 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1132629 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0024011059221515 0.250044481781731 0.2491545808994955 0.3990376746076917 7.058774627838557e-05 0.0109188419829382 0.0 0.0 0.0 0.0 89 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1132637 MMP2 PECAM1 MMP2-PECAM1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0023997028263446 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0024819960935566 0.0001990509171164 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132665 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0023943496386572 0.893316592628645 0.2491545808994955 0.2461374514707439 0.0007691101630988 0.0004471667362236 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1132671 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Myeloid Cells Mast Cells -> Myeloid Cells 0.0023937726477043 0.6303682835571691 0.7426180951053148 0.7827641335561659 9.902323108165852e-05 0.0005184623914895 0.0 0.0 0.0 0.0 23 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1132673 VWF SELP VWF-SELP Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0023931549575515 0.2486570577556728 0.7760344326192508 0.2461374514707439 0.0001077515101466 0.0036702914086929 0.0 0.0 0.0 0.0 684 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1132687 VWF SELP VWF-SELP Plasma Cells CXCL14+ Fibroblasts Plasma Cells -> CXCL14+ Fibroblasts 0.002391416072942 0.7158082793127664 0.8819126042133903 0.7204611100467462 0.0003457348439318 0.0001189339410417 0.0 0.0 0.0 0.0 306 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1132750 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0023802203157219 0.250044481781731 0.7779918296243433 0.2461374514707439 7.058774627838557e-05 0.0053794918117879 0.0 0.0003654970760233 0.0441199333536716 0.0 684 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1132751 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0023800204597304 0.250044481781731 0.7154802332407408 0.2461374514707439 7.058774627838557e-05 0.0058465532256424 0.0 0.0 0.0 0.0 937 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1132780 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0023751156923897 0.2490567623945399 0.836885603004631 0.2461374514707439 0.000126812416921 0.0027591088867233 0.0 0.0 0.0 0.0 1 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1132819 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0023679277207138 0.255669001367946 0.7754239189773715 0.2461374514707439 0.0002269856810233 0.0015914585039484 0.0 0.0 0.0 0.0 20 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1132845 CD34 SELP CD34-SELP Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0023636833289027 0.2491449441646273 0.8347297932672282 0.2461374514707439 0.0003767662344862 0.0009042150166242 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1132901 VWF LRP1 VWF-LRP1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0023526512313507 0.9011206516381156 0.2550748532138862 0.2461374514707439 0.0008850282134344 0.0003386430177035 0.0 0.0005980861244019 0.0385344080151569 0.0 19 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132927 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0023471805298518 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0001826541344284 0.0023576674662702 0.0 7.309941520467836e-05 0.0350514044147427 0.0 684 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1132970 VWF SELP VWF-SELP Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0023400420289747 0.2486570577556728 0.7760344326192508 0.2461374514707439 0.0001077515101466 0.0032078747392388 0.0 0.0 0.0 0.0 64 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1132982 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0023386402204505 0.2490567623945399 0.6571792026963191 0.2461374514707439 0.000126812416921 0.0032020139126304 0.0 0.0 0.0 0.0 4 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1133002 VWF SELP VWF-SELP Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0023354990576373 0.2486570577556728 0.4623922682986163 0.2461374514707439 0.0001077515101466 0.0053213839468185 0.0 0.0 0.0 0.0 937 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1133014 A2M LRP1 A2M-LRP1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0023329210842858 0.7460047258226694 0.2550748532138862 0.2461374514707439 0.0010163752993685 0.0003386430177035 0.0 0.0 0.0 0.0 24 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1133015 VWF SELP VWF-SELP Mast Cells CXCL14+ Fibroblasts Mast Cells -> CXCL14+ Fibroblasts 0.0023329198174114 0.8525936146535493 0.8819126042133903 0.8567148457705164 0.0002103933337194 0.0001189339410417 0.0 0.0 0.0 0.0 148 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1133034 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0023289629501665 0.250044481781731 0.4630027772793905 0.3990376746076917 7.058774627838557e-05 0.0048929293424311 0.0 0.0 0.0 0.0 89 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133040 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0023285974957139 0.250044481781731 0.6347970925105053 0.2461374514707439 7.058774627838557e-05 0.0057802287131517 0.0 0.0 0.0 0.0 684 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133059 CD34 SELP CD34-SELP Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0023256366432778 0.2491449441646273 0.6572093097629401 0.2461374514707439 0.0003767662344862 0.0010419094417808 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1133081 VWF LRP1 VWF-LRP1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0023211208838126 0.2486570577556728 0.7346293219749174 0.2461374514707439 0.0001077515101466 0.0032275631628407 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133140 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0023073715390201 0.7753420160918723 0.2550748532138862 0.2461374514707439 0.0009153913192522 0.0003386430177035 0.0 0.0 0.0 0.0 29 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1133180 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0022988718101848 0.2490567623945399 0.4641352222874551 0.2461374514707439 0.000126812416921 0.0040904475843412 0.0 0.0 0.0 0.0 15 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1133213 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) CXCL14+ Fibroblasts 11q13 Invasive Tumor Cells (G1/S) -> CXCL14+ Fibroblasts 0.0022921139380434 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.0003521782369754 0.0001189339410417 0.0 0.0 0.0 0.0 380 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1133238 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Mast Cells B Cells -> Mast Cells 0.0022864511383533 0.6342079770588467 0.8341464445360613 0.6198216015396206 0.0002327631000826 0.0001871866311057 0.0 0.0 0.0 0.0 97 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1133292 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.002276585916706 0.7800321422220979 0.2491073778594529 0.2461374514707439 0.0014623066995027 0.0001990509171164 0.0 0.0 0.0 0.0 15 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1133339 C3 LRP1 C3-LRP1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0022673599802089 0.7796725988275006 0.2550748532138862 0.2461374514707439 0.000819605673545 0.0003386430177035 0.0 0.0010416666666666 0.107968041459728 0.0 24 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1133340 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0022671292548274 0.255669001367946 0.7757991160529997 0.2461374514707439 0.0002269856810233 0.0012252690191386 0.0 0.0 0.0 0.0 20 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1133343 THBS2 CD36 THBS2-CD36 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0022662621320819 0.2510234128936706 0.7373999388878224 0.2461374514707439 5.260070730345377e-05 0.0056518532344078 0.0 0.0001778726431874 0.1473835446737894 0.0 937 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133354 VWF SELP VWF-SELP Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.00226469343314 0.2486570577556728 0.7478729882108823 0.2461374514707439 0.0001077515101466 0.0027351735586246 0.0 0.0 0.0 0.0 20 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1133383 VWF SELP VWF-SELP Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0022588503026844 0.2486570577556728 0.941479368642921 0.2461374514707439 0.0001077515101466 0.0021392900294222 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1133404 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0022543189371472 0.2490567623945399 0.8923034233058523 0.2461374514707439 0.000126812416921 0.00189193058407 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1133419 THBS2 CD36 THBS2-CD36 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0022514266616833 0.2510234128936706 0.2562573700401372 0.3990376746076917 5.260070730345377e-05 0.0096442330625583 0.0 0.0 0.0 0.0 89 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133463 THBS2 CD36 THBS2-CD36 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0022405387154471 0.2510234128936706 0.6176321640000088 0.2461374514707439 5.260070730345377e-05 0.0063011237754475 0.0 0.0 0.0 0.0 74 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133467 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0022394715652299 0.4629984640915818 0.2550748532138862 0.2461374514707439 0.0012814156885439 0.0003386430177035 0.0 0.0046296296296296 0.6598680263947214 0.0 24 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133496 VWF ITGA9 VWF-ITGA9 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0022329944700062 0.2486570577556728 0.950463483645931 0.2461374514707439 0.0001077515101466 0.0019776346124415 0.0 0.0 0.0 0.0 20 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1133500 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0022324110390146 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.000716220684292 0.0004471667362236 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133507 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0022307916713716 0.8284725546778968 0.2491073778594529 0.2461374514707439 0.0012187708721425 0.0001990509171164 0.0 0.0 0.0 0.0 3 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1133524 MMRN2 CD93 MMRN2-CD93 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0022280115482431 0.250044481781731 0.6587114738285964 0.2461374514707439 7.058774627838557e-05 0.0042738820064046 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133525 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0022279416863638 0.250044481781731 0.6347970925105053 0.2461374514707439 7.058774627838557e-05 0.0044340558155446 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133562 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0022191173494864 0.7856500335676843 0.2491545808994955 0.2461374514707439 0.0005542667491398 0.0004471667362236 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133576 VWF LRP1 VWF-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0022142479181833 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0001077515101466 0.0028784826949613 0.0 0.0 0.0 0.0 2 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133579 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0022133153757619 0.250044481781731 0.4630027772793905 0.2461374514707439 7.058774627838557e-05 0.0058437228618857 0.0 0.0 0.0 0.0 937 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133587 THBS2 CD36 THBS2-CD36 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0022104072953074 0.724503440376099 0.2562573700401372 0.2461374514707439 0.0009736808737186 0.0002621208738319 0.0 0.0 0.0 0.0 24 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133605 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0022052344299545 0.2491408586098361 0.7841656220878274 0.2461374514707439 0.0001826541344284 0.001309307002134 0.0 0.0 0.0 0.0 20 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133618 C3 LRP1 C3-LRP1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0022022522057649 0.8509500867818902 0.2550748532138862 0.2461374514707439 0.0006305085967044 0.0003386430177035 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1133659 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0021923537038416 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0014431743145616 0.0001990509171164 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133720 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0021762092253791 0.7468485855611411 0.2550748532138862 0.2461374514707439 0.0006689050756654 0.0003386430177035 0.0 0.0 0.0 0.0 24 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133793 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0021530726384617 0.785133132759182 0.2491073778594529 0.2461374514707439 0.001039571291679 0.0001990509171164 0.0 0.0 0.0 0.0 24 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1133801 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.002149594921274 0.8571898293845529 0.2491545808994955 0.2461374514707439 0.0004196880356983 0.0004471667362236 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133817 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0021457174243677 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0007263013575398 0.0003386430177035 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1133818 VWF SELP VWF-SELP B Cells CXCL14+ Fibroblasts B Cells -> CXCL14+ Fibroblasts 0.0021454973436566 0.6332974881236617 0.8819126042133903 0.6198216015396206 0.00023686843287 0.0001189339410417 0.0 0.0 0.0 0.0 800 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1133904 A2M LRP1 A2M-LRP1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0021253218723216 0.8392912392980421 0.2550748532138862 0.2461374514707439 0.0005164482812395 0.0003386430177035 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1133912 VWF SELP VWF-SELP Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0021231489559342 0.2486570577556728 0.6572093097629401 0.2461374514707439 0.0001077515101466 0.002113171886167 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1133942 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0021169991084342 0.250044481781731 0.6347970925105053 0.2461374514707439 7.058774627838557e-05 0.003263637675389 0.0 0.0 0.0 0.0 64 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133967 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0021113713588446 0.250044481781731 0.7830372268649692 0.2461374514707439 7.058774627838557e-05 0.0026038611777234 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1133975 THBS2 CD36 THBS2-CD36 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0021091018139454 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0008527942416386 0.0002621208738319 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134064 CD34 SELP CD34-SELP Apocrine Cells B Cells Apocrine Cells -> B Cells 0.002085067375356 0.2491449441646273 0.7760344326192508 0.2461374514707439 0.0003767662344862 0.0004582650848664 0.0 0.0 0.0 0.0 11 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1134147 MMRN2 CD93 MMRN2-CD93 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0020531850774271 0.250044481781731 0.6587114738285964 0.2461374514707439 7.058774627838557e-05 0.0026174949623928 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1134163 VWF LRP1 VWF-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0020494481368484 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0001077515101466 0.0018097844702233 0.0 0.0 0.0 0.0 4 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134176 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0020433553368458 0.8560892486218385 0.2491073778594529 0.2461374514707439 0.0006966068981631 0.0001990509171164 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134232 VWF SELP VWF-SELP Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0020235904921842 0.2486570577556728 0.4623922682986163 0.2461374514707439 0.0001077515101466 0.0022515473538965 0.0 0.003030303030303 0.2924193070772878 0.0 15 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1134242 VWF LRP1 VWF-LRP1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0020215269372301 0.2486570577556728 0.6207977546603366 0.2461374514707439 0.0001077515101466 0.0016667952436519 0.0 0.0 0.0 0.0 11 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134257 VWF LRP1 VWF-LRP1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0020161113214501 0.7848266128497919 0.2550748532138862 0.2461374514707439 0.0004024409845247 0.0003386430177035 0.0 0.0009469696969696 0.0610128126906651 0.0 24 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134283 THBS2 CD36 THBS2-CD36 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0020076515713541 0.2510234128936706 0.6176321640000088 0.2461374514707439 5.260070730345377e-05 0.0032616151102094 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134310 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0020000895533506 0.6303642896310324 0.2491073778594529 0.2461374514707439 0.0008320501336843 0.0001990509171164 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134316 THBS2 CD36 THBS2-CD36 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0019984687428491 0.2510234128936706 0.6176321640000088 0.2461374514707439 5.260070730345377e-05 0.0031731220372828 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134342 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0019911762861287 0.2510234128936706 0.2562573700401372 0.3990376746076917 0.0009262556366009 0.0002621208738319 0.0 0.0 0.0 0.0 97 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134346 THBS2 CD36 THBS2-CD36 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0019879436100862 0.7809827257946271 0.2562573700401372 0.2461374514707439 0.0004779710276932 0.0002621208738319 0.0 0.0 0.0 0.0 24 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134349 THBS2 CD36 THBS2-CD36 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0019872429452546 0.2510234128936706 0.6176321640000088 0.2461374514707439 5.260070730345377e-05 0.0030676679668133 0.0 6.0916179337231965e-05 0.0397022623782871 0.0 684 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134449 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0019502608212935 0.6319926036888139 0.2550748532138862 0.2461374514707439 0.0004094805141934 0.0003386430177035 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1134461 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0019476245983634 0.2451358214448441 0.0 1.0 0.0010709508378277 0.0107131540183669 0.0019405780871466 0.0260439190812551 0.8129371147047403 0.0010090817356205 991 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1134482 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Apocrine Cells B Cells -> Apocrine Cells 0.001939923654008 0.6301823358791634 0.2491545808994955 0.2461374514707439 0.0003083910058032 0.0004471667362236 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1134486 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0019373847305645 0.250044481781731 0.9195415044619336 0.2461374514707439 7.058774627838557e-05 0.0013235329769289 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1134494 VWF LRP1 VWF-LRP1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0019357924611668 0.7158082793127664 0.2550748532138862 0.2461374514707439 0.0003457348439318 0.0003386430177035 0.0 0.0 0.0 0.0 24 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134495 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0019349910142201 0.2491408586098361 0.6331674633943454 0.2461374514707439 0.0001826541344284 0.0007400708115376 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134533 VWF SELP VWF-SELP Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0019179801376427 0.2486570577556728 0.8347297932672282 0.2461374514707439 0.0001077515101466 0.0009042150166242 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1134565 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0019085395815508 0.9275752708651288 0.2550748532138862 0.2461374514707439 0.000245041593909 0.0003386430177035 0.0 0.0 0.0 0.0 29 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134579 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.001902525521751 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.0003521782369754 0.0003386430177035 0.0 0.0 0.0 0.0 4 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134614 VWF SELP VWF-SELP Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0018871076487439 0.2486570577556728 0.6572093097629401 0.2461374514707439 0.0001077515101466 0.0010419094417808 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1134624 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.001884630577839 0.2490567623945399 0.7470475610360806 0.2461374514707439 0.000126812416921 0.0007714919761827 0.0 0.0 0.0 0.0 20 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1134638 THBS2 CD36 THBS2-CD36 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0018825466720593 0.2510234128936706 0.7763054211764489 0.2461374514707439 5.260070730345377e-05 0.0017638974017382 0.0 0.0 0.0 0.0 20 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134663 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0018780551946611 0.250044481781731 0.8347945881127203 0.2461374514707439 7.058774627838557e-05 0.0012097093680331 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1134680 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0018734964593448 0.2490567623945399 0.7746834992804791 0.2461374514707439 0.000126812416921 0.00071798405859 0.0 0.0 0.0 0.0 11 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1134697 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0018702029763516 0.7205550478301406 0.2491545808994955 0.2461374514707439 0.0002165306714062 0.0004471667362236 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1134703 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0018689760871789 0.2491408586098361 0.930308383061206 0.2461374514707439 0.0001826541344284 0.0004089864655001 0.0 0.0 0.0 0.0 20 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134752 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0018539222170906 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.000393370777602 0.0002621208738319 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134775 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0018460247377316 0.2491408586098361 0.8537710813834968 0.2461374514707439 0.0001826541344284 0.0004138063814779 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134816 VWF LRP1 VWF-LRP1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0018347032819971 0.8525936146535493 0.2550748532138862 0.2461374514707439 0.0002103933337194 0.0003386430177035 0.0 0.0 0.0 0.0 3 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134835 THBS2 CD36 THBS2-CD36 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0018287808928343 0.8581959463413404 0.2562573700401372 0.2461374514707439 0.0002636300075004 0.0002621208738319 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1134866 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0018222919601249 0.2490567623945399 0.7754072541855492 0.2461374514707439 0.000126812416921 0.0006074333625108 0.0 0.0 0.0 0.0 11 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1134871 MMRN2 CD93 MMRN2-CD93 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0018212940062507 0.250044481781731 0.7779918296243433 0.2461374514707439 7.058774627838557e-05 0.001079730675535 0.0 0.0 0.0 0.0 11 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1134958 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0017995903758197 0.2490567623945399 0.896164124004365 0.2461374514707439 0.000126812416921 0.0004874986369898 0.0 0.0 0.0 0.0 20 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1134970 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.001797106212462 0.250044481781731 0.7461459456652184 0.2461374514707439 7.058774627838557e-05 0.0010390313650636 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1134975 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0017954995582595 0.940547666092272 0.2491545808994955 0.2461374514707439 0.0001298888146421 0.0004471667362236 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1134978 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0017941412721432 0.2490567623945399 0.4638256179742202 0.2461374514707439 0.000126812416921 0.0009249287638231 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1135026 VWF LRP1 VWF-LRP1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0017808292098429 0.6332974881236617 0.2550748532138862 0.2461374514707439 0.00023686843287 0.0003386430177035 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135028 THBS2 CD36 THBS2-CD36 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0017804081385262 0.2510234128936706 0.8587566561291643 0.2461374514707439 5.260070730345377e-05 0.0011409783203169 0.0 0.0 0.0 0.0 20 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135056 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0017762910711487 0.250044481781731 0.6347970925105053 0.2461374514707439 7.058774627838557e-05 0.0011388334136451 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135079 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0017707647204785 0.250044481781731 0.9003264838243337 0.2461374514707439 7.058774627838557e-05 0.0007880862995141 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135138 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.001756160870261 0.250044481781731 0.7154802332407408 0.2461374514707439 7.058774627838557e-05 0.0009436211854823 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135165 VWF LRP1 VWF-LRP1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0017475895715048 0.2486570577556728 0.7769451595923457 0.2461374514707439 0.0001077515101466 0.0005558995075445 0.0 0.0 0.0 0.0 20 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135283 CD34 SELP CD34-SELP Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0017011666712021 0.2491449441646273 0.8819126042133903 0.2461374514707439 0.0003767662344862 0.0001189339410417 0.0 0.0 0.0 0.0 20 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1135287 VWF LRP1 VWF-LRP1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0016979740788663 0.2486570577556728 0.8755243548400705 0.2461374514707439 0.0001077515101466 0.0004150165744076 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135301 VWF SELP VWF-SELP Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0016919008408102 0.2486570577556728 0.7760344326192508 0.2461374514707439 0.0001077515101466 0.0004582650848664 0.0 0.0 0.0 0.0 11 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1135302 THBS2 CD36 THBS2-CD36 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0016912213753296 0.2510234128936706 0.7373999388878224 0.2461374514707439 5.260070730345377e-05 0.0009761781830445 0.0 0.0 0.0 0.0 15 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135306 VWF LRP1 VWF-LRP1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.001688163536907 0.2486570577556728 0.2550748532138862 1.0 0.0001077515101466 0.0003386430177035 0.0 0.0001146683790477 0.0073880297909988 0.0 991 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135320 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0016810416677486 0.2491408586098361 0.2491073778594529 1.0 0.0001826541344284 0.0001990509171164 0.0 5.0454086781029264e-05 0.0338572166113431 0.0 991 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135356 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0016641267256046 0.250044481781731 0.8514619504364779 0.2461374514707439 7.058774627838557e-05 0.0005740632036187 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135368 MMRN2 CD93 MMRN2-CD93 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0016581142709314 0.250044481781731 0.6587114738285964 0.2461374514707439 7.058774627838557e-05 0.0007261054236978 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135383 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0016506215425688 0.6242573126045354 0.2562573700401372 0.2461374514707439 0.0001959417442809 0.0002621208738319 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135393 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0016429563988594 0.250044481781731 0.2491545808994955 1.0 7.058774627838557e-05 0.0004471667362236 0.0 0.00016818028927 0.0204047983795842 0.0 991 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135412 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0016276403008226 0.250044481781731 0.4630027772793905 0.2461374514707439 7.058774627838557e-05 0.0009242223287825 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135414 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0016264170738939 0.250044481781731 0.6347970925105053 0.2461374514707439 7.058774627838557e-05 0.000671064546954 0.0 0.0 0.0 0.0 11 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135536 THBS2 CD36 THBS2-CD36 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0015748624096955 0.2510234128936706 0.6176321640000088 0.2461374514707439 5.260070730345377e-05 0.0007598956708367 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135586 THBS2 CD36 THBS2-CD36 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.001555430000824 0.2510234128936706 0.6176321640000088 0.2461374514707439 5.260070730345377e-05 0.0007053434767499 0.0 0.0 0.0 0.0 11 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135635 MMRN2 CD93 MMRN2-CD93 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0015320572865153 0.250044481781731 0.8817184225858201 0.2461374514707439 7.058774627838557e-05 0.0003375370073613 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1135673 THBS2 CD36 THBS2-CD36 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0015180643841026 0.2510234128936706 0.8765901449012573 0.2461374514707439 5.260070730345377e-05 0.0004295051170816 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1135679 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0015160100227308 0.2490567623945399 0.8341464445360613 0.2461374514707439 0.000126812416921 0.0001871866311057 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1135865 THBS2 CD36 THBS2-CD36 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0014387891634072 0.2510234128936706 0.2562573700401372 1.0 5.260070730345377e-05 0.0002621208738319 0.0 0.0001261352169525 0.206466902457854 0.0 991 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1136041 VWF SELP VWF-SELP Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0013803896005393 0.2486570577556728 0.8819126042133903 0.2461374514707439 0.0001077515101466 0.0001189339410417 0.0 0.0 0.0 0.0 20 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1141056 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0007706066048495 0.7941469661104034 0.0 0.2461374514707439 1.0 0.0107131540183669 0.0 0.0065176908752327 0.2034437596783457 0.0 179 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1142572 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0007035127859031 0.9356727248601746 0.0 0.2461374514707439 1.0 0.0052641644527029 0.0 0.0101010101010101 0.9964906199904684 0.0 33 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1142635 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0007013378596558 0.9184503888425788 0.0 0.2461374514707439 1.0 0.0052641644527029 0.0 0.0252525252525252 1.0 0.0 33 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1143078 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.000683498541668 0.0 0.956444566971872 0.2461374514707439 0.0043309883979474 1.0 0.0 0.0083333333333333 0.0962910971427887 0.0 15 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1144443 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0006406975140796 0.6605327397359113 0.0 0.2461374514707439 1.0 0.0042544667714474 0.0 0.0009310986964618 0.035557932209767 0.0 179 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1144594 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0006364379497521 0.7296454584598743 0.0 0.2461374514707439 0.7029371915698084 0.0052641644527029 0.0 0.0101449275362318 1.0 0.0 230 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1144720 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0006333752239124 0.0 0.878254460598671 0.2461374514707439 0.0029865299894135 1.0 0.0 0.0222222222222222 0.2631882752029219 0.0 15 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1145472 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0006146531655305 0.8924110508951895 0.0 0.2461374514707439 1.0 0.0024549141020602 0.0 0.0270750988142292 1.0 0.0 230 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1145500 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0006140762588917 0.0 0.8817184225858201 0.2461374514707439 0.0024707251961819 1.0 0.0 0.0133333333333333 0.1140888410154603 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1145888 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0006056507433508 0.8718210606749883 0.0 0.2461374514707439 1.0 0.00229999322473 0.0 0.0101010101010101 1.0 0.0 33 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1145897 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0006054817794388 0.0 0.657421674383923 0.2461374514707439 0.0096292529477205 0.3162217004298525 0.0 0.0 0.0 0.0 184 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1146736 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0005873593026224 0.9184503888425788 0.0 0.2461374514707439 1.0 0.0018162987722844 0.0 0.0303030303030303 1.0 0.0 33 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1148225 CD48 CD2 CD48-CD2 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0005607030597679 0.0 0.8960994285623033 0.2461374514707439 0.001408836344877 1.0 0.0 0.0 0.0 0.0 74 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1148870 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0005508470495281 0.4625081978296446 0.0 0.3990376746076917 0.3558005706994493 0.0042544667714474 0.0 0.0103092783505154 0.3937032906524719 0.0 97 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1148903 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0005501584502233 0.7296454584598743 0.0 0.2461374514707439 0.293296467876477 0.0052641644527029 0.0 0.007864632983794 0.7758662668038273 0.0 1049 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1150633 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0005261652657029 0.9356727248601746 0.0 0.2461374514707439 0.1750253929104546 0.0052641644527029 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1151640 C1QB LRP1 C1QB-LRP1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0005139073180066 0.0 0.7346293219749174 0.2461374514707439 0.0010187287506117 1.0 0.0 0.0077247191011235 0.0572960055280143 0.0 89 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1151686 A2M LRP1 A2M-LRP1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0005134476427941 0.0 0.7346293219749174 0.2461374514707439 0.0010132735682542 1.0 0.0 0.0028089887640449 0.03326011565896 0.0 89 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1152033 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.000509489617604 0.6249837837987587 0.0 0.2461374514707439 0.2159908053119969 0.0052641644527029 0.0 0.0 0.0 0.0 179 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1152287 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0005064130695613 0.6593525851613742 0.0 0.2461374514707439 0.4518617096918393 0.00229999322473 0.0 0.0 0.0 0.0 179 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1152517 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0005038690465444 0.0 0.4642836810638544 0.3990376746076917 0.0096292529477205 0.0917308979735958 0.0 0.0037453183520599 0.2060886607742581 0.0 89 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1152678 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0005020667624794 0.0 0.930308383061206 0.2461374514707439 0.0043309883979474 0.1615013370958009 0.0 0.0 0.0 0.0 9 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1153112 CD34 SELP CD34-SELP Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0004970447938999 0.9559599666576516 0.0 0.2461374514707439 1.0 0.0006408390492498 0.0 0.0 0.0 0.0 33 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1153116 VWF SELP VWF-SELP Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0004970233983706 0.955713094717548 0.0 0.2461374514707439 1.0 0.0006408390492498 0.0 0.0 0.0 0.0 33 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1153700 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0004904455722623 0.9184503888425788 0.0 0.2461374514707439 0.1169448695751571 0.0052641644527029 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1153906 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0004882518557786 0.8924110508951895 0.0 0.2461374514707439 1.0 0.0006167564619166 0.0 0.0043478260869565 0.8220667164888921 0.0 230 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1153964 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0004876767662809 0.6249837837987587 0.0 0.2461374514707439 0.1661175896787547 0.0052641644527029 0.0 0.0014409221902017 0.1421506792205423 0.0 694 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1153970 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0004875682071664 0.9845127857250529 0.0 0.2461374514707439 1.0 0.0005543771898401 0.0 0.0151515151515151 1.0 0.0 33 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1154800 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0004788979021267 0.8840293712888387 0.0 0.2461374514707439 1.0 0.0005543771898401 0.0 0.009090909090909 1.0 0.0 33 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1155134 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0004756841321165 0.0 0.6593689120110077 0.2461374514707439 0.0029865299894135 0.2390217618875283 0.0 0.0018115942028985 0.1793755721058471 0.0 184 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1155442 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0004728882794768 0.2534163760166434 0.0 0.3990376746076917 0.2100740470724093 0.0052641644527029 0.0 0.0051546391752577 0.5085184091703936 0.0 97 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1155560 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0004717505176558 0.7941469661104034 0.0 0.2461374514707439 0.0526353932596327 0.0107131540183669 0.0 0.0333333333333333 1.0 0.0 5 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1155871 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0004686702779888 0.7766289238087107 0.0 0.2461374514707439 1.0 0.0005543771898401 0.0 0.0043290043290043 0.8490061091526552 0.0 33 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1156199 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0004653882646136 0.6605327397359113 0.0 0.2461374514707439 0.1468839381042521 0.0042544667714474 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1156956 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0004581107269281 0.7797302331085993 0.0 0.2461374514707439 0.1132020978253244 0.0042544667714474 0.0 0.0044444444444444 0.1697298630812879 0.0 75 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1157106 CD48 CD2 CD48-CD2 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0004566854841064 0.928447473463448 0.0 0.2461374514707439 1.0 0.0003969695918337 0.0 0.0174418604651162 1.0 0.0 86 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1157318 VEGFC FLT1 VEGFC-FLT1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0004549418242921 0.8718210606749883 0.0 0.2461374514707439 0.1796394187986057 0.00229999322473 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1157346 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0004546843172067 0.0 0.7346293219749174 0.2461374514707439 0.00048865795825 1.0 0.0 0.0087390761548064 0.0854524834253595 0.0 89 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1157580 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0004526972432638 0.0 0.7763400818577846 0.2461374514707439 0.0096292529477205 0.0467761235673353 0.0 0.0 0.0 0.0 11 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1157590 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0004526425355516 0.0 0.878254460598671 0.2461374514707439 0.0029865299894135 0.1332188634280341 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1157813 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0004506603047204 0.0 0.4642836810638544 0.2461374514707439 0.0096292529477205 0.0761275033764692 0.0 0.0 0.0 0.0 89 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1159025 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0004399485167152 0.4625081978296446 0.0 0.2461374514707439 0.149715856631667 0.0042544667714474 0.0 0.0007246376811594 0.0276733472415143 0.0 230 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1159355 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0004370400084054 0.0 0.885766439573873 0.2461374514707439 0.0096292529477205 0.0331922776397286 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1159469 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0004360341696948 0.0 0.8817184225858201 0.2461374514707439 0.0024707251961819 0.1281708518900828 0.0 0.0111111111111111 0.3143161778304498 0.0 9 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1159609 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0004349019574677 0.7941469661104034 0.0 0.2461374514707439 0.0323110954490285 0.0107131540183669 0.0 0.0 0.0 0.0 4 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1159696 COL4A2 CD93 COL4A2-CD93 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0004340622185261 0.8840293712888387 0.0 0.2461374514707439 0.5544396796022323 0.0005543771898401 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1160297 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0004285580583366 0.0 0.657421674383923 0.2461374514707439 0.0096292529477205 0.0397596998227057 0.0 0.0 0.0 0.0 2 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1160966 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0004227473786257 0.7797302331085993 0.0 0.2461374514707439 0.0699064461360958 0.0042544667714474 0.0 0.0012007684918347 0.0458564111350741 0.0 694 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1160982 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0004225753026774 0.6303682835571691 0.0 0.2461374514707439 0.0342558468646473 0.0107131540183669 0.0 0.0206349206349206 0.644100175199334 0.0 15 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1161107 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0004215053341712 0.0 0.8817184225858201 0.2461374514707439 0.0002584008880758 1.0 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1161244 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.000420567355454 0.6342079770588467 0.0 0.2461374514707439 0.0673400749834054 0.0052641644527029 0.0 0.0 0.0 0.0 179 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1161454 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0004189810828946 0.0 0.7763400818577846 0.2461374514707439 0.0096292529477205 0.0293997450046583 0.0 0.0 0.0 0.0 64 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1161882 COL4A1 CD93 COL4A1-CD93 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0004155260930382 0.7766289238087107 0.0 0.2461374514707439 0.4857192596400828 0.0005543771898401 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1162327 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0004116094356088 0.4630253981438691 0.0 0.2461374514707439 0.7696906278989153 0.0005543771898401 0.0 0.0043478260869565 0.5308880308880314 0.0 230 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1162358 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0004114279015167 0.6303682835571691 0.0 0.2461374514707439 0.0291791383241764 0.0107131540183669 0.0 0.0 0.0 0.0 33 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1162447 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0004107403661904 0.9184503888425788 0.0 0.2461374514707439 0.1169448695751571 0.0018162987722844 0.0 0.0 0.0 0.0 15 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1162741 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0004085109535866 0.7487535481622718 0.0 0.2461374514707439 0.1027229557481577 0.0024549141020602 0.0 0.012396694214876 0.5037037708306433 0.0 33 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1162978 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0004067751113032 0.6303682835571691 0.0 0.2461374514707439 0.0272543760657653 0.0107131540183669 0.0 0.0070134822279722 0.2189194333100323 0.0 1049 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1163040 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0004062304092884 0.8978557803479422 0.0 0.2461374514707439 0.0477973731763516 0.0042544667714474 0.0 0.0087719298245614 0.3349931508183314 0.0 19 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1163152 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0004053698080209 0.0 0.4642836810638544 0.2461374514707439 0.0096292529477205 0.040323117011325 0.0 0.0026680896478121 0.1855795792890609 0.0 937 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1163933 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0003990460827749 0.0 0.7763400818577846 0.2461374514707439 0.0096292529477205 0.0219439768073448 0.0 0.0007309941520467 0.1003629407185932 0.0 684 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1163969 CD48 CD2 CD48-CD2 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0003987754741223 0.9011089648206808 0.0 0.2461374514707439 0.4567172527116189 0.0003969695918337 0.0 0.0 0.0 0.0 75 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1164217 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0003967876761663 0.6582846571368821 0.0 0.2461374514707439 0.4344545964241579 0.0005543771898401 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1164256 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0003964642359101 0.8721681415062816 0.0 0.2461374514707439 0.0425206505665654 0.0042544667714474 0.0 0.0 0.0 0.0 33 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1164635 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0003935016603662 0.6630837220165452 0.0 0.2461374514707439 0.4103175828613323 0.0005543771898401 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1165066 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0003900889888881 0.6249837837987587 0.0 0.2461374514707439 0.0435116250366991 0.0052641644527029 0.0 0.0 0.0 0.0 86 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1165116 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0003896967493395 0.0 0.6331674633943454 0.2461374514707439 0.0043309883979474 0.0518891167572028 0.0 0.00390625 0.1999271425208861 0.0 64 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1165317 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0003879687216977 0.4625081978296446 0.0 0.2461374514707439 0.0704104148800194 0.0042544667714474 0.0 0.0015888147442008 0.0606755945238159 0.0 1049 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1165513 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0003864330780618 0.6249837837987587 0.0 0.2461374514707439 0.0411214967239829 0.0052641644527029 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1166472 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0003791394695283 0.0 0.7779918296243433 0.2461374514707439 0.0024707251961819 0.0627790816848129 0.0 0.0015625 0.0342678589790893 0.0 64 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1166724 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.000377266657805 0.7487535481622718 0.0 0.2461374514707439 0.0637288077574987 0.0024549141020602 0.0 0.0 0.0 0.0 15 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1166768 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0003769795981348 0.0 0.9130058539314824 0.2461374514707439 0.0096292529477205 0.0132636308162813 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1166805 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.000376705748928 0.4604235282221027 0.0 0.2461374514707439 0.454846709299195 0.0005543771898401 0.0 0.00527950310559 1.0 0.0 230 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1166855 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0003762178696882 0.4636527906642655 0.0 0.3990376746076917 0.0666348171285698 0.00229999322473 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1167038 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0003749767804561 0.0 0.944024288971064 0.2461374514707439 0.0024707251961819 0.0484215930647349 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1167378 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.000372470565636 0.0 0.885766439573873 0.2461374514707439 0.0096292529477205 0.0127192475389894 0.0 0.0 0.0 0.0 9 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1167602 C1QB LRP1 C1QB-LRP1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0003707937023404 0.0 0.6207977546603366 0.2461374514707439 0.0010187287506117 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1167644 A2M LRP1 A2M-LRP1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0003704620381123 0.0 0.6207977546603366 0.2461374514707439 0.0010132735682542 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1167931 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0003683036129959 0.0 0.7167436199046466 0.2461374514707439 0.0043309883979474 0.0326667674102811 0.0 0.0 0.0 0.0 15 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1168293 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0003652339415137 0.0 0.9015117569158254 0.2461374514707439 0.0043309883979474 0.0246995741084876 0.0 0.0 0.0 0.0 15 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1168907 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0003607241717775 0.0 0.6331674633943454 0.2461374514707439 0.0043309883979474 0.0326412663903893 0.0 0.0 0.0 0.0 184 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1169459 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0003563819372943 0.7783550150988336 0.0 0.2461374514707439 0.1928969878996252 0.0005543771898401 0.0 0.0002881844380403 0.035188543834077 0.0 694 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1169499 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0003561276264878 0.6160088550075702 0.0 0.2461374514707439 0.0548063857429699 0.0024549141020602 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1169714 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0003544396775264 0.0 0.4630488285702799 0.3990376746076917 0.0029865299894135 0.0359289752254096 0.0 0.0 0.0 0.0 89 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1169726 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0003543543686867 0.6249837837987587 0.0 0.2461374514707439 0.0244483651952677 0.0052641644527029 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1169927 CD34 SELP CD34-SELP Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0003528282720845 0.9303167350027568 0.0 0.2461374514707439 0.1314667522621683 0.0006408390492498 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1170006 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0003522184710325 0.6342079770588467 0.0 0.2461374514707439 0.0673400749834054 0.0018162987722844 0.0 0.0 0.0 0.0 179 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1170231 VWF SELP VWF-SELP Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0003503358636009 0.9275752708651288 0.0 0.2461374514707439 0.1263644540569636 0.0006408390492498 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1170255 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0003501866935429 0.0 0.7467524951532132 0.2461374514707439 0.0096292529477205 0.0104195741475089 0.0 0.0 0.0 0.0 20 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1170349 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0003494503607184 0.0 0.777821334064334 0.2461374514707439 0.0029865299894135 0.0318483483218543 0.0 0.0022522522522522 0.2850258323227372 0.0 74 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1170352 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0003494186314996 0.4636527906642655 0.0 0.2461374514707439 0.0693389464442948 0.00229999322473 0.0 0.0007246376811594 0.0802810322681095 0.0 230 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1170566 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0003479528525126 0.0 0.4630488285702799 0.2461374514707439 0.0029865299894135 0.0521374123931907 0.0 0.0018726591760299 0.3331614934333265 0.0 89 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1170638 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0003473696849908 0.7941469661104034 0.0 0.2461374514707439 0.0083898580598364 0.0107131540183669 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1170763 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0003465772640984 0.7160288858520609 0.0 0.2461374514707439 0.0186793449598515 0.0052641644527029 0.0 0.0021739130434782 0.0998399031855485 0.0 230 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1170949 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0003450946279233 0.6303682835571691 0.0 0.2461374514707439 0.0101610580570933 0.0107131540183669 0.0 0.0044513457556935 0.1389446866232677 0.0 230 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1171206 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0003433050204549 0.7797302331085993 0.0 0.2461374514707439 0.0200499113739789 0.0042544667714474 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1171358 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0003422867789164 0.4630253981438691 0.0 0.2461374514707439 0.2545335314555431 0.0005543771898401 0.0 0.0012392755004766 0.1513208019404398 0.0 1049 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1171439 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0003416859301749 0.0 0.4642836810638544 0.2461374514707439 0.0096292529477205 0.0144613249009303 0.0 0.0555555555555555 0.3219575016097878 0.0 15 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1171535 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0003410025225272 0.6605327397359113 0.0 0.2461374514707439 0.0227314494836465 0.0042544667714474 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1171576 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0003406783810525 0.6582846571368821 0.0 0.2461374514707439 0.1740454925211078 0.0005543771898401 0.0 0.0 0.0 0.0 179 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1171736 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.000339570285052 0.7487535481622718 0.0 0.2461374514707439 0.0338862305197021 0.0024549141020602 0.0 0.0047846889952153 0.1944119817241079 0.0 19 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1172137 MMRN2 CD93 MMRN2-CD93 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0003363221879824 0.9468422434493456 0.0 0.2461374514707439 0.1120119983652299 0.0005543771898401 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1172736 CD34 SELP CD34-SELP CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0003314709264113 0.7168245244832976 0.0 0.2461374514707439 0.1173076386135379 0.0006408390492498 0.0 0.0021739130434782 0.1257466205595726 0.0 230 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1172825 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0003307807026056 0.6249837837987587 0.0 0.2461374514707439 0.0161757332769496 0.0052641644527029 0.0 0.0 0.0 0.0 75 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1173044 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0003293016875214 0.0 0.6593689120110077 0.2461374514707439 0.0029865299894135 0.026308073552735 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1173183 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0003280632041341 0.0 0.6207977546603366 0.2461374514707439 0.00048865795825 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1173224 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0003277591364031 0.6605327397359113 0.0 0.2461374514707439 0.0179229861158654 0.0042544667714474 0.0 0.0 0.0 0.0 4 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1173519 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0003257326301298 0.0 0.6331674633943454 0.2461374514707439 0.0043309883979474 0.0176963220730796 0.0 0.0 0.0 0.0 74 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1173674 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.0003245020808156 0.7487535481622718 0.0 0.2461374514707439 0.1027229557481577 0.0006167564619166 0.0 0.0055096418732782 1.0 0.0 33 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1173729 COL4A2 CD93 COL4A2-CD93 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0003241270947872 0.0 0.6587114738285964 0.2461374514707439 0.0024707251961819 0.0289462771086338 0.0 0.0 0.0 0.0 184 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1174195 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0003204489854727 0.0 0.657421674383923 0.2461374514707439 0.0096292529477205 0.0069492509109592 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1174471 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0003183344226926 0.0 0.777821334064334 0.2461374514707439 0.0029865299894135 0.0182001711419816 0.0 0.0014619883040935 0.1751059495066875 0.0 684 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1174660 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0003168158251862 0.8721681415062816 0.0 0.2461374514707439 0.0110717612136884 0.0042544667714474 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1174899 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0003148340756533 0.6659645551150886 0.0 0.2461374514707439 0.1496557267835524 0.0003969695918337 0.0 0.0 0.0 0.0 179 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1174982 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0003140752352213 0.0 0.7167436199046466 0.2461374514707439 0.0043309883979474 0.0125623889131764 0.0 0.0 0.0 0.0 89 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1175042 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0003136442933119 0.6160088550075702 0.0 0.2461374514707439 0.0255753403203798 0.0024549141020602 0.0 0.0015856236786469 0.0644272265015939 0.0 86 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1175097 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0003133360156382 0.7745997874735252 0.0 0.2461374514707439 0.0215813276111062 0.00229999322473 0.0 0.0016810758885686 0.1862427405643462 0.0 694 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1175133 C1QB LRP1 C1QB-LRP1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0003130204159755 0.0 0.8604147465201248 0.2461374514707439 0.0010187287506117 0.0436001007095475 0.0 0.0166666666666666 0.3907380548998684 0.0 15 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1175172 A2M LRP1 A2M-LRP1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0003127404282789 0.0 0.8604147465201248 0.2461374514707439 0.0010132735682542 0.0436001007095475 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1175254 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0003121127364054 0.0 0.657421674383923 0.2461374514707439 0.0096292529477205 0.0059327142047454 0.0 0.0 0.0 0.0 4 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1175323 C1QB LRP1 C1QB-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0003115268971044 0.0 0.6207977546603366 0.2461374514707439 0.0010187287506117 0.0587195251380622 0.0 0.0 0.0 0.0 184 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1175340 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0003113998941144 0.8771078809726828 0.0 0.2461374514707439 0.0080232294691882 0.0052641644527029 0.0 0.0 0.0 0.0 19 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1175366 A2M LRP1 A2M-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0003112482453172 0.0 0.6207977546603366 0.2461374514707439 0.0010132735682542 0.0587195251380622 0.0 0.0006793478260869 0.087350946654543 0.0 184 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1175472 CD48 CD2 CD48-CD2 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.000310521631388 0.0 0.937587088419394 0.2461374514707439 0.001408836344877 0.0275738893167071 0.0 0.0 0.0 0.0 11 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1175987 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0003060744533474 0.8533682807143209 0.0 0.2461374514707439 0.0706049302656684 0.0005543771898401 0.0 0.0004116920543433 0.0807412149914628 0.0 694 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1176178 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0003046090934734 0.633566764858408 0.0 0.2461374514707439 0.0799339500711946 0.0006408390492498 0.0 0.0 0.0 0.0 179 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1176189 C1QB LRP1 C1QB-LRP1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0003044949257844 0.0 0.9078204025796472 0.2461374514707439 0.0010187287506117 0.0350138403862125 0.0 0.0 0.0 0.0 9 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1176230 A2M LRP1 A2M-LRP1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0003042225638919 0.0 0.9078204025796472 0.2461374514707439 0.0010132735682542 0.0350138403862125 0.0 0.0046296296296296 0.2703279202929273 0.0 9 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1176250 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0003040614041294 0.0 0.4630488285702799 0.2461374514707439 0.0029865299894135 0.0232163927704059 0.0 0.0008893632159373 0.174018103504598 0.0 937 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1176331 C1QB LRP1 C1QB-LRP1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0003034642519908 0.0 0.6207977546603366 0.2461374514707439 0.0010187287506117 0.0501711964086628 0.0 0.01171875 0.2791176605110409 0.0 64 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1176365 A2M LRP1 A2M-LRP1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0003031928120061 0.0 0.6207977546603366 0.2461374514707439 0.0010132735682542 0.0501711964086628 0.0 0.0 0.0 0.0 64 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1176456 C1QB LRP1 C1QB-LRP1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0003025213191729 0.0 0.7346293219749174 0.2461374514707439 0.0010187287506117 0.0416128058995347 0.0 0.000667022411953 0.0264266721433909 0.0 937 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1176491 A2M LRP1 A2M-LRP1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0003022507226143 0.0 0.7346293219749174 0.2461374514707439 0.0010132735682542 0.0416128058995347 0.0 0.0007114905727499 0.0422055331706626 0.0 937 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1176565 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0003016974557415 0.9470274865242416 0.0 0.2461374514707439 0.0061455194924501 0.0052641644527029 0.0 0.0 0.0 0.0 29 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1176579 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0003015846436163 0.6593525851613742 0.0 0.2461374514707439 0.0201572483258557 0.00229999322473 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1176710 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0003005943120258 0.7745997874735252 0.0 0.2461374514707439 0.016822895653248 0.00229999322473 0.0 0.001937984496124 0.2147050862984324 0.0 86 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1176828 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.000299683067015 0.7487535481622718 0.0 0.2461374514707439 0.0637288077574987 0.0006167564619166 0.0 0.0 0.0 0.0 15 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1176861 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0002992962612477 0.0 0.8817184225858201 0.2461374514707439 0.0002584008880758 0.1281708518900828 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1176904 CD48 CD2 CD48-CD2 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0002989907762108 0.0 0.8960994285623033 0.2461374514707439 0.001408836344877 0.0229905310518441 0.0 0.0 0.0 0.0 64 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1176988 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0002982022983174 0.6342079770588467 0.0 0.2461374514707439 0.0085570823799139 0.0052641644527029 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1177114 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0002970338041212 0.6249837837987587 0.0 0.2461374514707439 0.0084812136822336 0.0052641644527029 0.0 0.0 0.0 0.0 4 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1177130 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0002969265640192 0.4625081978296446 0.0 0.2461374514707439 0.0141498126994191 0.0042544667714474 0.0 0.0138888888888888 0.5304058221290248 0.0 24 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1177225 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0002963095277549 0.6593525851613742 0.0 0.2461374514707439 0.018132161410931 0.00229999322473 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1177252 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0002961231904226 0.2534163760166434 0.0 1.0 0.0050543892975134 0.0052641644527029 0.0 0.001765893037336 0.1742098889135707 0.0 991 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1177402 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0002949611027483 0.7835752212271604 0.0 0.2461374514707439 0.0064863313435223 0.0052641644527029 0.0 0.0 0.0 0.0 24 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1177586 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0002936056850127 0.7160288858520609 0.0 0.2461374514707439 0.0069047442087267 0.0052641644527029 0.0 0.0017476962186209 0.0802653177818359 0.0 1049 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1177766 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0002922162159345 0.0 0.777821334064334 0.2461374514707439 0.0029865299894135 0.0108892901157311 0.0 0.0 0.0 0.0 64 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1177905 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0002911774028138 0.2490567623945399 0.0 0.3990376746076917 0.011649387573427 0.0052641644527029 0.0 0.0 0.0 0.0 97 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1177917 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0002910224712081 0.6342079770588467 0.0 0.2461374514707439 0.0073929685753755 0.0052641644527029 0.0 0.0 0.0 0.0 86 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1178006 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.000290252946341 0.7160288858520609 0.0 0.2461374514707439 0.0186793449598515 0.0018162987722844 0.0 0.0 0.0 0.0 230 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1178050 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0002898603689255 0.7487535481622718 0.0 0.2461374514707439 0.0131092554497256 0.0024549141020602 0.0 0.0141065830721003 0.5731801530141803 0.0 29 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1178156 CD48 CD2 CD48-CD2 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0002890182140997 0.9426443637490616 0.0 0.2461374514707439 0.0632786830726401 0.0003969695918337 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1178217 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0002886141362477 0.0 0.8381155706134242 0.2461374514707439 0.0096292529477205 0.0029095741067474 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1178427 COL4A2 CD93 COL4A2-CD93 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0002869668283407 0.0 0.7779918296243433 0.2461374514707439 0.0024707251961819 0.0118035014556376 0.0 0.0 0.0 0.0 74 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1178457 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0002867187255236 0.6160088550075702 0.0 0.2461374514707439 0.0149256517769723 0.0024549141020602 0.0 0.0012121212121212 0.0492510353701073 0.0 75 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1178753 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0002842548210311 0.4604235282221027 0.0 0.2461374514707439 0.0839650520556947 0.0005543771898401 0.0 0.0004766444232602 0.0934797002927851 0.0 1049 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1178837 CD48 CD2 CD48-CD2 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0002836161410788 0.0 0.6614977577544194 0.2461374514707439 0.001408836344877 0.0226890201466244 0.0 0.0 0.0 0.0 184 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1178927 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0002828912047929 0.6160088550075702 0.0 0.2461374514707439 0.0548063857429699 0.0006167564619166 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1179196 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0002805041199199 0.7296454584598743 0.0 0.2461374514707439 0.0051524613572059 0.0052641644527029 0.0 0.0069444444444444 0.685087301243447 0.0 24 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1179605 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0002772434825304 0.4630253981438691 0.0 0.3990376746076917 0.0443339118517084 0.0005543771898401 0.0 0.002061855670103 0.2517613342355612 0.0 97 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1179639 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0002769477474297 0.0 0.8604147465201248 0.2461374514707439 0.00048865795825 0.0436001007095475 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1179646 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0002768577546147 0.6593525851613742 0.0 0.2461374514707439 0.0120646829101097 0.00229999322473 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1179770 COL4A2 CD93 COL4A2-CD93 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0002756618803825 0.0 0.4630027772793905 0.2461374514707439 0.0024707251961819 0.0155837683010033 0.0 0.0 0.0 0.0 89 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1179773 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0002756263426076 0.0 0.6207977546603366 0.2461374514707439 0.00048865795825 0.0587195251380622 0.0 0.0 0.0 0.0 184 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1179802 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0002753474101443 0.6342079770588467 0.0 0.2461374514707439 0.0053032910137447 0.0052641644527029 0.0 0.0004803073967339 0.0220587682350395 0.0 694 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1179919 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0002743430896412 0.831981591331937 0.0 0.2461374514707439 0.0048935684578858 0.0042544667714474 0.0 0.0 0.0 0.0 3 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1179927 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0002742778496139 0.0 0.8998347793593909 0.2461374514707439 0.0029865299894135 0.0064362797035136 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1180061 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0002729913777846 0.8023917560710954 0.0 0.2461374514707439 0.0085367158000785 0.0024549141020602 0.0 0.0016032585146026 0.0651437669933497 0.0 1049 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1180288 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0002709671523232 0.6160088550075702 0.0 0.2461374514707439 0.0106340017102282 0.0024549141020602 0.0 0.0 0.0 0.0 179 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1180433 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0002697388236841 0.7487535481622718 0.0 0.2461374514707439 0.0338862305197021 0.0006167564619166 0.0 0.0 0.0 0.0 19 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1180467 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0002694047400614 0.0 0.9078204025796472 0.2461374514707439 0.00048865795825 0.0350138403862125 0.0 0.0 0.0 0.0 9 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1180485 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0002692801734093 0.4636527906642655 0.0 0.2461374514707439 0.014525360548861 0.00229999322473 0.0 0.00015888147442 0.0176021329091183 0.0 1049 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1180524 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0002689723986254 0.0 0.7472387841445823 0.2461374514707439 0.0029865299894135 0.0068935067166085 0.0 0.0166666666666666 1.0 0.0 20 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1180546 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0002688018733621 0.8630183004227985 0.0 0.2461374514707439 0.0016575843792215 0.0107131540183669 0.0 0.0165079365079365 0.5152801401594673 0.0 75 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1180559 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0002686912341037 0.6630837220165452 0.0 0.2461374514707439 0.0415873844357376 0.0005543771898401 0.0 0.0 0.0 0.0 179 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1180581 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0002684928417605 0.0 0.6207977546603366 0.2461374514707439 0.00048865795825 0.0501711964086628 0.0 0.0030381944444444 0.0515493754831962 0.0 64 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1180674 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0002676585731103 0.0 0.7346293219749174 0.2461374514707439 0.00048865795825 0.0416128058995347 0.0 0.0008152496146092 0.0269202065029114 0.0 937 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1181144 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0002637297131071 0.7783550150988336 0.0 0.2461374514707439 0.0316800311254893 0.0005543771898401 0.0 0.0 0.0 0.0 86 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1181215 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0002631447698392 0.0 0.6331674633943454 0.2461374514707439 0.0043309883979474 0.0049190726392343 0.0 0.0 0.0 0.0 11 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1181258 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0002627893226316 0.7840818683779507 0.0 0.2461374514707439 0.0032417203409647 0.0052641644527029 0.0 0.0069444444444444 0.3189330240649467 0.0 24 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1181270 C1QB LRP1 C1QB-LRP1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0002626924795785 0.0 0.9078204025796472 0.2461374514707439 0.0010187287506117 0.0144359394371152 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1181286 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0002625409510184 0.0 0.2491073778594529 0.3990376746076917 0.0043309883979474 0.0076066460958003 0.0 0.0 0.0 0.0 89 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1181293 A2M LRP1 A2M-LRP1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0002624575087635 0.0 0.9078204025796472 0.2461374514707439 0.0010132735682542 0.0144359394371152 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1181326 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0002620630953018 0.0 0.6593689120110077 0.2461374514707439 0.0029865299894135 0.0066828239855783 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1181410 C1QB LRP1 C1QB-LRP1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0002611714572578 0.0 0.6207977546603366 0.2461374514707439 0.0010187287506117 0.0203874717835032 0.0 0.0006396198830409 0.0362219391152221 0.0 684 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1181440 A2M LRP1 A2M-LRP1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0002609378469532 0.0 0.6207977546603366 0.2461374514707439 0.0010132735682542 0.0203874717835032 0.0 0.0003654970760233 0.0216717963535559 0.0 684 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1181524 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Dendritic Cells Apocrine Cells -> Dendritic Cells 0.0002602434249607 0.0 0.7779918296243433 0.2461374514707439 0.0002584008880758 0.0627790816848129 0.0 0.0 0.0 0.0 64 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1181635 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0002589014225344 0.8730912658940219 0.0 0.2461374514707439 0.0057086106530109 0.0024549141020602 0.0 0.0056818181818181 0.2308642282973781 0.0 24 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1181676 CD34 SELP CD34-SELP CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0002584762461492 0.633566764858408 0.0 0.2461374514707439 0.0298399317533219 0.0006408390492498 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1181772 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.000257386132201 0.0 0.944024288971064 0.2461374514707439 0.0002584008880758 0.0484215930647349 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1181795 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0002570975954858 0.0 0.885766439573873 0.2461374514707439 0.0096292529477205 0.0013756087909864 0.0 0.0 0.0 0.0 20 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1181849 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0002566037862862 0.7745997874735252 0.0 0.2461374514707439 0.0065101973396288 0.00229999322473 0.0 0.0044444444444444 0.492390331244405 0.0 75 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1181871 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0002564133307187 0.7783550150988336 0.0 0.2461374514707439 0.0267593032157803 0.0005543771898401 0.0 0.0 0.0 0.0 75 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1181933 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0002558505046662 0.0 0.6331674633943454 0.2461374514707439 0.0043309883979474 0.0041555861088636 0.0 0.0 0.0 0.0 2 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1181992 C1QB LRP1 C1QB-LRP1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0002553358380466 0.0 0.2550748532138862 0.3990376746076917 0.0010187287506117 0.0267255153180908 0.0 0.0 0.0 0.0 89 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1182017 A2M LRP1 A2M-LRP1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0002551074475343 0.0 0.2550748532138862 0.3990376746076917 0.0010132735682542 0.0267255153180908 0.0 0.0014044943820224 0.1221733325495991 0.0 89 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1182063 CD48 CD2 CD48-CD2 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0002547003135007 0.0 0.4603649459881741 0.3990376746076917 0.001408836344877 0.0105486447632276 0.0 0.0 0.0 0.0 89 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1182390 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0002517407392267 0.0 0.7779918296243433 0.2461374514707439 0.0024707251961819 0.0053794918117879 0.0 0.0007309941520467 0.0789119751725253 0.0 684 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1182612 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0002497396819074 0.6342079770588467 0.0 0.2461374514707439 0.0085570823799139 0.0018162987722844 0.0 0.0 0.0 0.0 5 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1182677 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.000249144422988 0.6160088550075702 0.0 0.2461374514707439 0.0255753403203798 0.0006167564619166 0.0 0.0 0.0 0.0 86 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1182753 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0002484899017935 0.6342079770588467 0.0 0.2461374514707439 0.0028649117803088 0.0052641644527029 0.0 0.0 0.0 0.0 75 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1182790 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0002480446292236 0.7475533330314548 0.0 0.2461374514707439 0.0029751676683741 0.0042544667714474 0.0 0.0 0.0 0.0 24 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1182938 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0002465537247732 0.8624864526942296 0.0 0.2461374514707439 0.0020100505037262 0.0052641644527029 0.0 0.0 0.0 0.0 3 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1182957 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.000246319574215 0.0 0.4630027772793905 0.3990376746076917 0.0024707251961819 0.0048929293424311 0.0 0.0 0.0 0.0 89 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1182998 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0002459273476943 0.0 0.6593689120110077 0.2461374514707439 0.0029865299894135 0.0045642085393754 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1183001 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0002458900913743 0.7160288858520609 0.0 0.2461374514707439 0.0069047442087267 0.0018162987722844 0.0 0.0009532888465204 0.0384092840784159 0.0 1049 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1183013 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0002456655321938 0.8949858186325867 0.0 0.2461374514707439 0.001895566065636 0.0052641644527029 0.0 0.0 0.0 0.0 19 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1183046 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0002451857249154 0.0 0.6331674633943454 0.2461374514707439 0.0043309883979474 0.0032187363284526 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1183116 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0002444362318578 0.6249837837987587 0.0 0.2461374514707439 0.00263399584678 0.0052641644527029 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1183162 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0002438564436548 0.2490567623945399 0.0 0.3990376746076917 0.011649387573427 0.0018162987722844 0.0 0.0 0.0 0.0 97 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1183171 CD48 CD2 CD48-CD2 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0002437336421867 0.4593282471594782 0.0 0.2461374514707439 0.0467114894617178 0.0003969695918337 0.0 0.0 0.0 0.0 24 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1183173 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0002437266908992 0.6342079770588467 0.0 0.2461374514707439 0.0073929685753755 0.0018162987722844 0.0 0.0 0.0 0.0 86 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1183304 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0002422971849465 0.0 0.7167436199046466 0.2461374514707439 0.0043309883979474 0.0026482500471321 0.0 0.0004669156883671 0.1742300619781838 0.0 937 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1183373 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0002416789580159 0.8684504425765611 0.0 0.2461374514707439 0.0168149984327668 0.0005543771898401 0.0 0.0 0.0 0.0 75 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1183420 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0002410793786428 0.6160088550075702 0.0 0.2461374514707439 0.0052742025956585 0.0024549141020602 0.0 0.0 0.0 0.0 15 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1183725 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0002377241163088 0.6342079770588467 0.0 0.2461374514707439 0.002196330917593 0.0052641644527029 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1183741 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0002375385824645 0.6301823358791634 0.0 0.2461374514707439 0.0208904415011529 0.0005543771898401 0.0 0.0 0.0 0.0 179 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1183756 CD48 CD2 CD48-CD2 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0002374263726499 0.0 0.4603649459881741 0.2461374514707439 0.001408836344877 0.0112209532878862 0.0 0.0 0.0 0.0 89 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1183778 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0002371485509158 0.6582846571368821 0.0 0.2461374514707439 0.0198024073017111 0.0005543771898401 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1183941 COL4A2 CD93 COL4A2-CD93 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0002356425875604 0.0 0.6587114738285964 0.2461374514707439 0.0024707251961819 0.0042738820064046 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1184090 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0002340882670213 0.0 0.4630027772793905 0.2461374514707439 0.0024707251961819 0.0058437228618857 0.0 0.0007470651013874 0.226704413363336 0.0 937 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1184118 C1QB LRP1 C1QB-LRP1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0002337218755233 0.0 0.6207977546603366 0.2461374514707439 0.0010187287506117 0.0104714078116759 0.0 0.0 0.0 0.0 74 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1184146 A2M LRP1 A2M-LRP1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0002335128180746 0.0 0.6207977546603366 0.2461374514707439 0.0010132735682542 0.0104714078116759 0.0 0.0 0.0 0.0 74 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1184181 CD48 CD2 CD48-CD2 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0002331300960429 0.7719609236370527 0.0 0.2461374514707439 0.0212837736082081 0.0003969695918337 0.0 0.0 0.0 0.0 19 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1184213 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0002327884640973 0.0 0.6331674633943454 0.2461374514707439 0.0043309883979474 0.0023576674662702 0.0 9.137426900584796e-05 0.0283657200489082 0.0 684 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1184248 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0002324196339056 0.0 0.9078204025796472 0.2461374514707439 0.00048865795825 0.0144359394371152 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1184249 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0002324120886918 0.4593282471594782 0.0 0.2461374514707439 0.0351142257737683 0.0003969695918337 0.0 0.0 0.0 0.0 230 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1184287 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0002320248346288 0.8630183004227985 0.0 0.2461374514707439 0.0006856224272495 0.0107131540183669 0.0 0.0052602436323366 0.1641936940356083 0.0 86 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1184309 CD34 SELP CD34-SELP T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0002317887834052 0.633566764858408 0.0 0.2461374514707439 0.015517736049123 0.0006408390492498 0.0 0.0 0.0 0.0 86 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1184338 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0002313424732561 0.255669001367946 0.0 0.3990376746076917 0.0061207051981986 0.0024549141020602 0.0 0.0014058106841611 0.0571210461766708 0.0 97 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1184365 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0002310738951486 0.0 0.6207977546603366 0.2461374514707439 0.00048865795825 0.0203874717835032 0.0 0.0003045808966861 0.0095148358732554 0.0 684 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1184410 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0002305990765715 0.6342079770588467 0.0 0.2461374514707439 0.0053032910137447 0.0018162987722844 0.0 0.0014409221902017 0.0580566844355307 0.0 694 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1184430 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0002303962566869 0.8684504425765611 0.0 0.2461374514707439 0.0126216524880575 0.0005543771898401 0.0 0.0 0.0 0.0 86 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1184443 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0002302515808609 0.7487535481622718 0.0 0.2461374514707439 0.0131092554497256 0.0006167564619166 0.0 0.0 0.0 0.0 29 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1184449 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0002301901130424 0.7205550478301406 0.0 0.2461374514707439 0.0151307911035231 0.0005543771898401 0.0 0.0004766444232602 0.0375731544118532 0.0 1049 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1184455 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0002301364631682 0.6301823358791634 0.0 0.2461374514707439 0.0172764782878141 0.0005543771898401 0.0 0.0 0.0 0.0 694 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1184492 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0002295777989157 0.0 0.4630488285702799 0.2461374514707439 0.0029865299894135 0.0043013567716651 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1184504 C1QB LRP1 C1QB-LRP1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0002294050354015 0.0 0.9078204025796472 0.2461374514707439 0.0010187287506117 0.0064028969591119 0.0 0.003125 0.3212540797736178 0.0 20 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1184530 A2M LRP1 A2M-LRP1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0002291998392412 0.0 0.9078204025796472 0.2461374514707439 0.0010132735682542 0.0064028969591119 0.0 0.0 0.0 0.0 20 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1184665 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0002277560056207 0.6160088550075702 0.0 0.2461374514707439 0.0149256517769723 0.0006167564619166 0.0 0.0 0.0 0.0 75 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1184732 CD48 CD2 CD48-CD2 Apocrine Cells Endothelial Cells Apocrine Cells -> Endothelial Cells 0.0002271081889048 0.0 0.7763428264267787 0.2461374514707439 0.001408836344877 0.0050968401714881 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1184837 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0002259107763457 0.0 0.2550748532138862 0.3990376746076917 0.00048865795825 0.0267255153180908 0.0 0.0009363295880149 0.0559713203621566 0.0 89 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1184858 VEGFC FLT1 VEGFC-FLT1 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0002256382102938 0.8963332422588541 0.0 0.2461374514707439 0.0026007495851186 0.00229999322473 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1184863 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0002256072724 0.4593282471594782 0.0 0.3990376746076917 0.0181222899145132 0.0003969695918337 0.0 0.0 0.0 0.0 97 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1184886 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0002254079880033 0.6332974881236617 0.0 0.2461374514707439 0.0131302879503246 0.0006408390492498 0.0 0.0 0.0 0.0 179 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1184944 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0002248472830903 0.4604235282221027 0.0 0.3990376746076917 0.0126864732057784 0.0005543771898401 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1185050 CD48 CD2 CD48-CD2 Endothelial Cells Apocrine Cells Endothelial Cells -> Apocrine Cells 0.000223371934483 0.7719609236370527 0.0 0.2461374514707439 0.0164675938709007 0.0003969695918337 0.0 0.0 0.0 0.0 33 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1185137 COL4A1 CD93 COL4A1-CD93 Apocrine Cells 11q13 Invasive Tumor Cells Apocrine Cells -> 11q13 Invasive Tumor Cells 0.0002224826272372 0.0 0.6587114738285964 0.2461374514707439 0.0002584008880758 0.0289462771086338 0.0 0.0 0.0 0.0 184 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1185236 CD48 CD2 CD48-CD2 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0002211480765268 0.0 0.8581827408615759 0.2461374514707439 0.001408836344877 0.003930762149527 0.0 0.0 0.0 0.0 684 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1185276 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.000220797238151 0.7205550478301406 0.0 0.2461374514707439 0.0117842887908422 0.0005543771898401 0.0 0.0021739130434782 0.1713662564262348 0.0 230 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1185300 CD48 CD2 CD48-CD2 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0002204602578595 0.0 0.4603649459881741 0.2461374514707439 0.001408836344877 0.0071918009517169 0.0 0.0010672358591248 0.2608460519265829 0.0 937 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1185321 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.000220255817925 0.7160288858520609 0.0 0.2461374514707439 0.0012306151710811 0.0052641644527029 0.0 0.0 0.0 0.0 24 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1185340 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.000220081878017 0.7840818683779507 0.0 0.2461374514707439 0.0032417203409647 0.0018162987722844 0.0 0.0 0.0 0.0 24 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1185351 COL4A2 CD93 COL4A2-CD93 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0002199059577168 0.9188764516910942 0.0 0.2461374514707439 0.0090193130488293 0.0005543771898401 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1185446 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0002187105462894 0.0 0.7841656220878274 0.2461374514707439 0.0043309883979474 0.001309307002134 0.0 0.003125 0.3859662816109899 0.0 20 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1185571 COL4A2 CD93 COL4A2-CD93 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0002171523055016 0.0 0.6587114738285964 0.2461374514707439 0.0024707251961819 0.0026174949623928 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1185590 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.000216851639737 0.8023917560710954 0.0 0.2461374514707439 0.0085367158000785 0.0006167564619166 0.0 0.0005199757344657 0.0983145912778118 0.0 1049 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1185713 CD48 CD2 CD48-CD2 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0002153761875838 0.0 0.4603649459881741 0.2461374514707439 0.001408836344877 0.0062523288579129 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1185724 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Apocrine Cells 11q13 Invasive Tumor Cells -> Apocrine Cells 0.0002152436892806 0.6160088550075702 0.0 0.2461374514707439 0.0106340017102282 0.0006167564619166 0.0 0.0 0.0 0.0 179 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1185904 CD34 SELP CD34-SELP Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.000213172781633 0.7168245244832976 0.0 0.2461374514707439 0.0082993421103349 0.0006408390492498 0.0 0.0 0.0 0.0 1049 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1185911 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0002130434232365 0.0 0.8331580262014722 0.2461374514707439 0.0029865299894135 0.001526625481682 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1186021 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0002116794700966 0.8667347161816407 0.0 0.2461374514707439 0.0106228227237899 0.0003969695918337 0.0 0.0 0.0 0.0 694 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1186032 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0002114539651789 0.6659645551150886 0.0 0.2461374514707439 0.0137371823984124 0.0003969695918337 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1186089 CD48 CD2 CD48-CD2 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0002108333266932 0.0 0.6614977577544194 0.2461374514707439 0.001408836344877 0.0038288178384739 0.0 0.0 0.0 0.0 2 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1186103 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0002105873851105 0.8718210606749883 0.0 0.2461374514707439 0.0017670878089588 0.00229999322473 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1186109 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0002105270496504 0.743507317541692 0.0 0.2461374514707439 0.0020684923107111 0.00229999322473 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1186172 CD48 CD2 CD48-CD2 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0002096181151383 0.7719609236370527 0.0 0.2461374514707439 0.0112468593062777 0.0003969695918337 0.0 0.0 0.0 0.0 3 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1186213 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.000209070229277 0.633566764858408 0.0 0.2461374514707439 0.0083565457974945 0.0006408390492498 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1186273 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0002081063404987 0.6342079770588467 0.0 0.2461374514707439 0.0028649117803088 0.0018162987722844 0.0 0.0 0.0 0.0 75 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1186293 VWF SELP VWF-SELP CAFs, DCIS Associated Apocrine Cells CAFs, DCIS Associated -> Apocrine Cells 0.0002078912384822 0.7158082793127664 0.0 0.2461374514707439 0.0071496754272206 0.0006408390492498 0.0 0.0 0.0 0.0 230 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1186336 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0002072531510607 0.6160088550075702 0.0 0.2461374514707439 0.0021291294377375 0.0024549141020602 0.0 0.0003274823159549 0.0133062955790996 0.0 694 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1186341 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0002071185669917 0.633566764858408 0.0 0.2461374514707439 0.0078992851324392 0.0006408390492498 0.0 0.0007204610951008 0.0416739520586479 0.0 694 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1186364 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0002067876203842 0.0 0.6207977546603366 0.2461374514707439 0.00048865795825 0.0104714078116759 0.0 0.000563063063063 0.0470647358536185 0.0 74 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1186448 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0002057409758808 0.8949858186325867 0.0 0.2461374514707439 0.001895566065636 0.0018162987722844 0.0 0.0 0.0 0.0 19 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1186452 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0002056966567149 0.6582846571368821 0.0 0.2461374514707439 0.0084325366891025 0.0005543771898401 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1186453 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0002056592353299 0.8730912658940219 0.0 0.2461374514707439 0.0057086106530109 0.0006167564619166 0.0 0.0018939393939393 0.3580972439250856 0.0 24 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1186469 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0002052820572062 0.8721681415062816 0.0 0.2461374514707439 0.0008193633790489 0.0042544667714474 0.0 0.0 0.0 0.0 29 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1186481 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0002050952866907 0.8840293712888387 0.0 0.2461374514707439 0.0061698665784747 0.0005543771898401 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1186485 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0002050274070117 0.7487535481622718 0.0 0.2461374514707439 0.0016417770622885 0.0024549141020602 0.0 0.0 0.0 0.0 3 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1186502 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0002047223976958 0.6342079770588467 0.0 0.2461374514707439 0.000895875398841 0.0052641644527029 0.0 0.0 0.0 0.0 4 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1186529 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0002042969662669 0.0 0.777821334064334 0.2461374514707439 0.0029865299894135 0.001271575589586 0.0 0.0 0.0 0.0 11 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1186533 CD48 CD2 CD48-CD2 Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0002042744514362 0.4593282471594782 0.0 0.2461374514707439 0.0161888123016941 0.0003969695918337 0.0 0.0 0.0 0.0 1049 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1186559 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0002038238534536 0.7487535481622718 0.0 0.2461374514707439 0.0015847932820241 0.0024549141020602 0.0 0.0037878787878787 0.1539094855315854 0.0 24 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1186615 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0002029682556183 0.0 0.9078204025796472 0.2461374514707439 0.00048865795825 0.0064028969591119 0.0 0.0 0.0 0.0 20 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1186650 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0002025686295153 0.2491449441646273 0.0 0.3990376746076917 0.0108445362943651 0.0006408390492498 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1186724 CD48 CD2 CD48-CD2 Apocrine Cells Pericytes Apocrine Cells -> Pericytes 0.0002014586917204 0.0 0.7763428264267787 0.2461374514707439 0.001408836344877 0.0024832440877005 0.0 0.0 0.0 0.0 9 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1186863 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0001994612591981 0.6303682835571691 0.0 0.2461374514707439 0.0003788349535045 0.0107131540183669 0.0 0.0039682539682539 0.1238654183075642 0.0 24 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1186885 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.000199090166386 0.6342079770588467 0.0 0.2461374514707439 0.002196330917593 0.0018162987722844 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1186923 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0001986299334939 0.0 0.8347945881127203 0.2461374514707439 0.0024707251961819 0.0012097093680331 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1186945 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0001982435675536 0.4636527906642655 0.0 0.2461374514707439 0.0023125636768155 0.00229999322473 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1186986 C1QB LRP1 C1QB-LRP1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0001975593023921 0.0 0.7346293219749174 0.2461374514707439 0.0010187287506117 0.0032275631628407 0.0 0.0083333333333333 0.3320956150135741 0.0 15 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1187007 A2M LRP1 A2M-LRP1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0001973825913177 0.0 0.7346293219749174 0.2461374514707439 0.0010132735682542 0.0032275631628407 0.0 0.0 0.0 0.0 15 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1187030 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0001970531762793 0.7482742921073442 0.0 0.2461374514707439 0.005733874009046 0.0005543771898401 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1187040 COL4A1 CD93 COL4A1-CD93 Apocrine Cells T Lymphocytes Apocrine Cells -> T Lymphocytes 0.0001969756152015 0.0 0.7779918296243433 0.2461374514707439 0.0002584008880758 0.0118035014556376 0.0 0.0 0.0 0.0 74 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1187064 CD48 CD2 CD48-CD2 Pericytes Apocrine Cells Pericytes -> Apocrine Cells 0.0001965054967871 0.7719609236370527 0.0 0.2461374514707439 0.0076331962782219 0.0003969695918337 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1187122 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0001955355461738 0.9184503888425788 0.0 0.2461374514707439 0.0004696576149175 0.0052641644527029 0.0 0.0 0.0 0.0 29 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1187130 CD48 CD2 CD48-CD2 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0001953816187998 0.0 0.6614977577544194 0.2461374514707439 0.001408836344877 0.0024251058581756 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1187168 VEGFC FLT1 VEGFC-FLT1 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001947974778043 0.7745997874735252 0.0 0.2461374514707439 0.0012459853895406 0.00229999322473 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1187181 CD34 SELP CD34-SELP Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0001946689223055 0.8963354148873306 0.0 0.2461374514707439 0.0038492365148421 0.0006408390492498 0.0 0.0 0.0 0.0 19 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1187216 COL4A1 CD93 COL4A1-CD93 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0001939545149669 0.9102252263107924 0.0 0.2461374514707439 0.0042860632265532 0.0005543771898401 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1187228 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0001938220622529 0.6659645551150886 0.0 0.2461374514707439 0.0081474500750471 0.0003969695918337 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1187258 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0001932760251883 0.8516956437178343 0.0 0.2461374514707439 0.000472352586488 0.0052641644527029 0.0 0.0 0.0 0.0 3 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1187293 COL4A2 CD93 COL4A2-CD93 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0001926266642018 0.0 0.7779918296243433 0.2461374514707439 0.0024707251961819 0.001079730675535 0.0 0.0 0.0 0.0 11 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1187312 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0001922853596866 0.7766289238087107 0.0 0.2461374514707439 0.0047694898966413 0.0005543771898401 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1187332 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0001919083685782 0.0 0.6331674633943454 0.2461374514707439 0.0043309883979474 0.0007400708115376 0.0 0.0 0.0 0.0 4 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1187365 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001915022334762 0.6160088550075702 0.0 0.2461374514707439 0.0052742025956585 0.0006167564619166 0.0 0.0 0.0 0.0 15 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1187421 CD34 SELP CD34-SELP Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0001905133062507 0.7871981482311898 0.0 0.2461374514707439 0.0038506427265089 0.0006408390492498 0.0 0.0208333333333333 1.0 0.0 24 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1187454 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0001900684753449 0.0 0.7461459456652184 0.2461374514707439 0.0024707251961819 0.0010390313650636 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1187500 CD48 CD2 CD48-CD2 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0001893454727509 0.7453966474499909 0.0 0.2461374514707439 0.006326966401379 0.0003969695918337 0.0 0.0 0.0 0.0 24 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1187508 COL4A1 CD93 COL4A1-CD93 Apocrine Cells CAFs, DCIS Associated Apocrine Cells -> CAFs, DCIS Associated 0.0001892158365129 0.0 0.4630027772793905 0.2461374514707439 0.0002584008880758 0.0155837683010033 0.0 0.0 0.0 0.0 89 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1187513 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0001890946076911 0.6303682835571691 0.0 0.2461374514707439 0.0002750231449378 0.0107131540183669 0.0 0.0 0.0 0.0 19 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1187545 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0001885786824902 0.6303682835571691 0.0 0.2461374514707439 0.0002705513462707 0.0107131540183669 0.0 0.0059523809523809 0.1857981274613463 0.0 24 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1187548 C1QB LRP1 C1QB-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0001884629435245 0.0 0.6207977546603366 0.2461374514707439 0.0010187287506117 0.0028784826949613 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1187559 A2M LRP1 A2M-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0001882943688797 0.0 0.6207977546603366 0.2461374514707439 0.0010132735682542 0.0028784826949613 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1187589 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0001876889762773 0.6630837220165452 0.0 0.2461374514707439 0.0048313935743179 0.0005543771898401 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1187594 CD48 CD2 CD48-CD2 Apocrine Cells Macrophages Apocrine Cells -> Macrophages 0.0001876237043532 0.0 0.7763428264267787 0.2461374514707439 0.001408836344877 0.0016204239758814 0.0 0.0 0.0 0.0 15 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1187621 CD34 SELP CD34-SELP Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0001870301771273 0.633566764858408 0.0 0.2461374514707439 0.0042829523358709 0.0006408390492498 0.0 0.0 0.0 0.0 75 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1187713 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0001853611459518 0.0 0.930308383061206 0.2461374514707439 0.0043309883979474 0.0004089864655001 0.0 0.0 0.0 0.0 20 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1187755 CD48 CD2 CD48-CD2 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0001847028735792 0.0 0.7763428264267787 0.2461374514707439 0.001408836344877 0.0014748371602574 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1187771 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0001844607443244 0.7160288858520609 0.0 0.2461374514707439 0.0012306151710811 0.0018162987722844 0.0 0.0 0.0 0.0 24 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1187787 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0001841203480275 0.250044481781731 0.0 0.3990376746076917 0.0070431301838115 0.0005543771898401 0.0 0.0 0.0 0.0 97 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1187801 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0001837676891979 0.255669001367946 0.0 0.3990376746076917 0.0061207051981986 0.0006167564619166 0.0 0.0 0.0 0.0 97 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1187845 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0001830848790354 0.0 0.8537710813834968 0.2461374514707439 0.0043309883979474 0.0004138063814779 0.0 0.0 0.0 0.0 1 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1187858 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0001828467692004 0.0 0.878254460598671 0.2461374514707439 0.0029865299894135 0.0005788283879716 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1187894 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0001821396159577 0.6303682835571691 0.0 0.2461374514707439 0.000219642761279 0.0107131540183669 0.0 0.0 0.0 0.0 29 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1187916 VWF SELP VWF-SELP T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0001818016467079 0.6332974881236617 0.0 0.2461374514707439 0.0036144684673052 0.0006408390492498 0.0 0.0 0.0 0.0 86 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1187917 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0001817777200839 0.6160088550075702 0.0 0.2461374514707439 0.0009692519480124 0.0024549141020602 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1187938 COL4A2 CD93 COL4A2-CD93 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001813120374392 0.7783550150988336 0.0 0.2461374514707439 0.0033449520260795 0.0005543771898401 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1188024 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0001796545361055 0.6630837220165452 0.0 0.2461374514707439 0.0037159398684439 0.0005543771898401 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1188042 CD48 CD2 CD48-CD2 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0001792269779073 0.0 0.7464347811605867 0.2461374514707439 0.001408836344877 0.0012805120781881 0.0 0.0 0.0 0.0 20 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1188197 COL4A2 CD93 COL4A2-CD93 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0001761242704986 0.4630253981438691 0.0 0.2461374514707439 0.0047240947268779 0.0005543771898401 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1188232 COL4A2 CD93 COL4A2-CD93 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0001753681831592 0.0 0.6587114738285964 0.2461374514707439 0.0024707251961819 0.0007261054236978 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1188266 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.000174792444802 0.0 0.7346293219749174 0.2461374514707439 0.00048865795825 0.0032275631628407 0.0 0.0 0.0 0.0 15 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1188268 VWF SELP VWF-SELP Myoepithelial Cells Apocrine Cells Myoepithelial Cells -> Apocrine Cells 0.0001747899416359 0.7158082793127664 0.0 0.2461374514707439 0.0025256125075084 0.0006408390492498 0.0 4.333131120547708e-05 0.954739012312376 0.0 1049 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1188288 C1QB LRP1 C1QB-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0001744362161524 0.0 0.6207977546603366 0.2461374514707439 0.0010187287506117 0.0018097844702233 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1188295 A2M LRP1 A2M-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.000174280188009 0.0 0.6207977546603366 0.2461374514707439 0.0010132735682542 0.0018097844702233 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1188328 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Apocrine Cells T Lymphocytes -> Apocrine Cells 0.0001736950856283 0.6301823358791634 0.0 0.2461374514707439 0.0031934983073077 0.0005543771898401 0.0 0.0 0.0 0.0 86 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1188366 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Basal-like Structured DCIS Cells Apocrine Cells -> Basal-like Structured DCIS Cells 0.0001727962331646 0.0 0.7779918296243433 0.2461374514707439 0.0002584008880758 0.0053794918117879 0.0 0.0002088554720133 0.016997915128281 0.0 684 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1188392 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.00017214514548 0.0 0.4630027772793905 0.2461374514707439 0.0024707251961819 0.0009242223287825 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1188397 C1QB LRP1 C1QB-LRP1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0001720597381512 0.0 0.6207977546603366 0.2461374514707439 0.0010187287506117 0.0016667952436519 0.0 0.0 0.0 0.0 11 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1188402 A2M LRP1 A2M-LRP1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0001719058356985 0.0 0.6207977546603366 0.2461374514707439 0.0010132735682542 0.0016667952436519 0.0 0.0 0.0 0.0 11 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1188412 VEGFC FLT1 VEGFC-FLT1 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0001716948401116 0.8317042416754105 0.0 0.2461374514707439 0.0005440770361181 0.00229999322473 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1188425 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0001714517519428 0.6342079770588467 0.0 0.2461374514707439 0.000895875398841 0.0018162987722844 0.0 0.0 0.0 0.0 4 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1188435 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.000171269975095 0.8630183004227985 0.0 0.2461374514707439 0.0001109003117737 0.0107131540183669 0.0 0.0 0.0 0.0 15 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1188458 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0001707019498636 0.9303167350027568 0.0 0.2461374514707439 0.0016860250240652 0.0006408390492498 0.0 0.0 0.0 0.0 29 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1188488 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.000170114680908 0.6659645551150886 0.0 0.2461374514707439 0.0037243679732516 0.0003969695918337 0.0 0.0 0.0 0.0 4 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1188532 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Luminal-like Amorphous DCIS Cells Apocrine Cells -> Luminal-like Amorphous DCIS Cells 0.0001690751155725 0.0 0.4630027772793905 0.3990376746076917 0.0002584008880758 0.0048929293424311 0.0 0.0 0.0 0.0 89 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1188606 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0001667443560205 0.0 0.6207977546603366 0.2461374514707439 0.00048865795825 0.0028784826949613 0.0 0.0 0.0 0.0 2 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1188607 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.000166722202635 0.0 0.2491073778594529 1.0 0.0043309883979474 0.0001990509171164 0.0 0.0001261352169525 0.207642984849246 0.0 991 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1188614 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Apocrine Cells Luminal-like Amorphous DCIS Cells -> Apocrine Cells 0.0001665270568715 0.2486570577556728 0.0 0.3990376746076917 0.0033537993821664 0.0006408390492498 0.0 0.0 0.0 0.0 97 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1188618 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0001663428144877 0.6301823358791634 0.0 0.2461374514707439 0.0024635726452692 0.0005543771898401 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1188644 CD34 SELP CD34-SELP Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0001655501268629 0.7168245244832976 0.0 0.2461374514707439 0.0018206581062216 0.0006408390492498 0.0 0.0 0.0 0.0 24 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1188661 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0001650701455901 0.6332974881236617 0.0 0.2461374514707439 0.0020251995753771 0.0006408390492498 0.0 0.0 0.0 0.0 694 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1188672 COL4A1 CD93 COL4A1-CD93 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001646814431775 0.8684504425765611 0.0 0.2461374514707439 0.0016831757123532 0.0005543771898401 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1188673 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Apocrine Cells Basal-like Structured DCIS Cells -> Apocrine Cells 0.0001646322532708 0.6160088550075702 0.0 0.2461374514707439 0.0021291294377375 0.0006167564619166 0.0 0.0 0.0 0.0 694 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1188677 VWF SELP VWF-SELP Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0001645496641706 0.6332974881236617 0.0 0.2461374514707439 0.0019871862905238 0.0006408390492498 0.0 0.0 0.0 0.0 75 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1188715 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0001637579099108 0.9184503888425788 0.0 0.2461374514707439 0.0004696576149175 0.0018162987722844 0.0 0.0 0.0 0.0 29 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1188728 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001635355143973 0.6342079770588467 0.0 0.2461374514707439 0.0002327631000826 0.0052641644527029 0.0 0.0 0.0 0.0 15 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1188748 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0001628642258314 0.7487535481622718 0.0 0.2461374514707439 0.0016417770622885 0.0006167564619166 0.0 0.0 0.0 0.0 3 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1188763 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0001625184591436 0.633566764858408 0.0 0.2461374514707439 0.0018436902762588 0.0006408390492498 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1188782 COL4A2 CD93 COL4A2-CD93 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0001620359389833 0.0 0.8817184225858201 0.2461374514707439 0.0024707251961819 0.0003375370073613 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1188786 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0001619081789235 0.7487535481622718 0.0 0.2461374514707439 0.0015847932820241 0.0006167564619166 0.0 0.0 0.0 0.0 24 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1188788 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0001618655970233 0.8516956437178343 0.0 0.2461374514707439 0.000472352586488 0.0018162987722844 0.0 0.0 0.0 0.0 3 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1188799 COL4A1 CD93 COL4A1-CD93 Apocrine Cells CAFs, Invasive Associated Apocrine Cells -> CAFs, Invasive Associated 0.0001617463729893 0.0 0.6587114738285964 0.2461374514707439 0.0002584008880758 0.0042738820064046 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1188838 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Myoepithelial Cells Apocrine Cells -> Myoepithelial Cells 0.0001606794787905 0.0 0.4630027772793905 0.2461374514707439 0.0002584008880758 0.0058437228618857 0.0 0.0001524622655892 0.0371609115759037 0.0 937 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1188871 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001597610022715 0.2490567623945399 0.0 1.0 0.000126812416921 0.0052641644527029 0.0 0.0003363605785401 0.0154478154945685 0.0 991 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1188883 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0001594942864977 0.6303682835571691 0.0 0.2461374514707439 9.902323108165852e-05 0.0107131540183669 0.0 0.0 0.0 0.0 3 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1188893 VWF SELP VWF-SELP CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0001589942891383 0.6332974881236617 0.0 0.2461374514707439 0.0016171311116606 0.0006408390492498 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1188934 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0001579974959576 0.6332974881236617 0.0 0.2461374514707439 0.0015572459193676 0.0006408390492498 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189024 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001557001245751 0.255669001367946 0.0 1.0 0.0002269856810233 0.0024549141020602 0.0 0.0006880102742867 0.027955305141963 0.0 991 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1189066 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0001543340774851 0.0 0.6207977546603366 0.2461374514707439 0.00048865795825 0.0018097844702233 0.0 0.0 0.0 0.0 4 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1189083 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Apocrine Cells Dendritic Cells -> Apocrine Cells 0.0001538307991973 0.6301823358791634 0.0 0.2461374514707439 0.0015409900107563 0.0005543771898401 0.0 0.0 0.0 0.0 75 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189104 COL4A2 CD93 COL4A2-CD93 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.000152970271907 0.8355319038299565 0.0 0.2461374514707439 0.001123788079051 0.0005543771898401 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189112 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0001526627418408 0.7463064942968751 0.0 0.2461374514707439 0.0012430446376512 0.0005543771898401 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189114 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Apocrine Cells CAFs, Invasive Associated -> Apocrine Cells 0.0001526072545919 0.6301823358791634 0.0 0.2461374514707439 0.00146889578236 0.0005543771898401 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189117 VWF SELP VWF-SELP Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0001525034746012 0.9011206516381156 0.0 0.2461374514707439 0.0008850282134344 0.0006408390492498 0.0 0.0 0.0 0.0 19 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189127 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0001522314662953 0.0 0.6207977546603366 0.2461374514707439 0.00048865795825 0.0016667952436519 0.0 0.0 0.0 0.0 11 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1189194 CD34 SELP CD34-SELP Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.000149745329794 0.8532069650852002 0.0 0.2461374514707439 0.00083777361258 0.0006408390492498 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1189206 COL4A1 CD93 COL4A1-CD93 Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells -> 11q13 Invasive Tumor Cells (Mitotic) 0.0001490545413068 0.0 0.6587114738285964 0.2461374514707439 0.0002584008880758 0.0026174949623928 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189211 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0001487790317387 0.7719609236370527 0.0 0.2461374514707439 0.0014378253178126 0.0003969695918337 0.0 0.0 0.0 0.0 29 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1189213 COL4A1 CD93 COL4A1-CD93 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0001487662066236 0.4604235282221027 0.0 0.2461374514707439 0.0017253404164066 0.0005543771898401 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189214 C1QB LRP1 C1QB-LRP1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0001487439017166 0.0 0.7769451595923457 0.2461374514707439 0.0010187287506117 0.0005558995075445 0.0 0.0 0.0 0.0 20 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1189218 A2M LRP1 A2M-LRP1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0001486108546044 0.0 0.7769451595923457 0.2461374514707439 0.0010132735682542 0.0005558995075445 0.0 0.0 0.0 0.0 20 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1189302 MMRN2 CD93 MMRN2-CD93 Macrophages Apocrine Cells Macrophages -> Apocrine Cells 0.0001452106327005 0.893316592628645 0.0 0.2461374514707439 0.0007691101630988 0.0005543771898401 0.0 0.0 0.0 0.0 19 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189316 C1QB LRP1 C1QB-LRP1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.000144520941085 0.0 0.8755243548400705 0.2461374514707439 0.0010187287506117 0.0004150165744076 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1189320 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Apocrine Cells 11q13 Invasive Tumor Cells (Mitotic) -> Apocrine Cells 0.0001443957570666 0.6160088550075702 0.0 0.2461374514707439 0.0009692519480124 0.0006167564619166 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1189321 A2M LRP1 A2M-LRP1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0001443916712888 0.0 0.8755243548400705 0.2461374514707439 0.0010132735682542 0.0004150165744076 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1189341 C1QB LRP1 C1QB-LRP1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001436859290703 0.0 0.2550748532138862 1.0 0.0010187287506117 0.0003386430177035 0.0 0.0006306760847628 0.0391724276250227 0.0 991 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1189348 A2M LRP1 A2M-LRP1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001435574061681 0.0 0.2550748532138862 1.0 0.0010132735682542 0.0003386430177035 0.0 0.0002943155062226 0.0485377896319247 0.0 991 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1189376 CD48 CD2 CD48-CD2 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0001426360475069 0.0 0.6614977577544194 0.2461374514707439 0.001408836344877 0.0003671083100858 0.0 0.0 0.0 0.0 4 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1189450 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0001394060601187 0.6160088550075702 0.0 0.2461374514707439 0.0001971810371238 0.0024549141020602 0.0 0.0 0.0 0.0 4 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1189482 CD48 CD2 CD48-CD2 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.000137569377155 0.0 0.7763428264267787 0.2461374514707439 0.001408836344877 0.0002517784065132 0.0 0.0 0.0 0.0 20 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1189496 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001369583922612 0.6342079770588467 0.0 0.2461374514707439 0.0002327631000826 0.0018162987722844 0.0 0.0 0.0 0.0 15 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1189508 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0001363406829061 0.0 0.8347945881127203 0.2461374514707439 0.0002584008880758 0.0012097093680331 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189513 CD34 SELP CD34-SELP B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001360194569968 0.633566764858408 0.0 0.2461374514707439 0.0006336851232098 0.0006408390492498 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1189530 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0001353895079437 0.6301823358791634 0.0 0.2461374514707439 0.000716220684292 0.0005543771898401 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189542 CD34 SELP CD34-SELP Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001348596073963 0.2491449441646273 0.0 1.0 0.0003767662344862 0.0006408390492498 0.0 0.0 0.0 0.0 991 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1189548 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0001345832827223 0.7856500335676843 0.0 0.2461374514707439 0.0005542667491398 0.0005543771898401 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189562 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001337972983898 0.2490567623945399 0.0 1.0 0.000126812416921 0.0018162987722844 0.0 0.0 0.0 0.0 991 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1189590 COL4A1 CD93 COL4A1-CD93 Apocrine Cells B Cells Apocrine Cells -> B Cells 0.0001322200057224 0.0 0.7779918296243433 0.2461374514707439 0.0002584008880758 0.001079730675535 0.0 0.0 0.0 0.0 11 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189604 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0001316025614366 0.0 0.7769451595923457 0.2461374514707439 0.00048865795825 0.0005558995075445 0.0 0.0013888888888888 0.2052629834064942 0.0 20 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1189617 VWF SELP VWF-SELP Myeloid Cells Apocrine Cells Myeloid Cells -> Apocrine Cells 0.0001306882965085 0.7848266128497919 0.0 0.2461374514707439 0.0004024409845247 0.0006408390492498 0.0 0.0 0.0 0.0 24 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189620 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Myeloid Cells Apocrine Cells -> Myeloid Cells 0.0001304640507683 0.0 0.7461459456652184 0.2461374514707439 0.0002584008880758 0.0010390313650636 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189621 MMRN2 CD93 MMRN2-CD93 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0001303669412054 0.8571898293845529 0.0 0.2461374514707439 0.0004196880356983 0.0005543771898401 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189657 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Mast Cells Apocrine Cells -> Mast Cells 0.0001278662574299 0.0 0.8755243548400705 0.2461374514707439 0.00048865795825 0.0004150165744076 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1189666 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001271274727221 0.0 0.2550748532138862 1.0 0.00048865795825 0.0003386430177035 0.0 0.0002382554097993 0.0339588994411007 0.0 991 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1189691 VWF SELP VWF-SELP Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0001254818701985 0.7158082793127664 0.0 0.2461374514707439 0.0003457348439318 0.0006408390492498 0.0 0.0 0.0 0.0 24 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189710 VWF SELP VWF-SELP CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0001237152850035 0.9275752708651288 0.0 0.2461374514707439 0.000245041593909 0.0006408390492498 0.0 0.0 0.0 0.0 29 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189711 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001236809293956 0.255669001367946 0.0 1.0 0.0002269856810233 0.0006167564619166 0.0 4.586735161911752e-05 0.0086723853221009 0.0 991 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1189713 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0001233254418326 0.6332974881236617 0.0 0.2461374514707439 0.0003521782369754 0.0006408390492498 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189740 COL4A1 CD93 COL4A1-CD93 Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0001210604909155 0.7766289238087107 0.0 0.2461374514707439 0.0002970267018348 0.0005543771898401 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189754 COL4A1 CD93 COL4A1-CD93 Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells -> 11q13 Invasive Tumor Cells (G1/S) 0.0001203736890576 0.0 0.6587114738285964 0.2461374514707439 0.0002584008880758 0.0007261054236978 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189773 VWF SELP VWF-SELP Mast Cells Apocrine Cells Mast Cells -> Apocrine Cells 0.0001189290710149 0.8525936146535493 0.0 0.2461374514707439 0.0002103933337194 0.0006408390492498 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189785 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Plasma Cells Apocrine Cells -> Plasma Cells 0.0001181613782015 0.0 0.4630027772793905 0.2461374514707439 0.0002584008880758 0.0009242223287825 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189788 MMRN2 CD93 MMRN2-CD93 B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001176509631848 0.6301823358791634 0.0 0.2461374514707439 0.0003083910058032 0.0005543771898401 0.0 0.0 0.0 0.0 15 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189800 VWF SELP VWF-SELP B Cells Apocrine Cells B Cells -> Apocrine Cells 0.0001154368478222 0.6332974881236617 0.0 0.2461374514707439 0.00023686843287 0.0006408390492498 0.0 0.0 0.0 0.0 15 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189817 MMRN2 CD93 MMRN2-CD93 Plasma Cells Apocrine Cells Plasma Cells -> Apocrine Cells 0.0001134225983915 0.7205550478301406 0.0 0.2461374514707439 0.0002165306714062 0.0005543771898401 0.0 0.0 0.0 0.0 24 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189828 COL4A1 CD93 COL4A1-CD93 Apocrine Cells CXCL14+ Fibroblasts Apocrine Cells -> CXCL14+ Fibroblasts 0.0001112223630533 0.0 0.8817184225858201 0.2461374514707439 0.0002584008880758 0.0003375370073613 0.0 0.0 0.0 0.0 20 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1189832 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Apocrine Cells 11q13 Invasive Tumor Cells (G1/S) -> Apocrine Cells 0.0001107376832607 0.6160088550075702 0.0 0.2461374514707439 0.0001971810371238 0.0006167564619166 0.0 0.0 0.0 0.0 4 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1189843 VWF SELP VWF-SELP Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 0.0001094300768608 0.2486570577556728 0.0 1.0 0.0001077515101466 0.0006408390492498 0.0 4.586735161911752e-05 1.0 0.0 991 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1189849 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Apocrine Cells CXCL14+ Fibroblasts -> Apocrine Cells 0.0001088920442774 0.940547666092272 0.0 0.2461374514707439 0.0001298888146421 0.0005543771898401 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1189897 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 9.964072678691296e-05 0.250044481781731 0.0 1.0 7.058774627838557e-05 0.0005543771898401 0.0 0.0 0.0 0.0 991 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1190679 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 1.8566920074572667e-05 0.0 0.0 1.0 0.0096292529477205 0.0042544667714474 0.0 0.0067272115708039 0.2569069572370654 0.0 991 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1190840 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 1.3787413388662117e-05 0.0 0.0 1.0 0.0029865299894135 0.00229999322473 0.0 0.0021863437605112 0.2422202689017633 0.0 991 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1190906 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 1.0538364895362456e-05 0.0 0.0 1.0 0.0024707251961819 0.0005543771898401 0.0 0.0005045408678102 0.0616065827972992 0.0 991 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1190922 CD48 CD2 CD48-CD2 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 9.07692267561122e-06 0.0 0.0 1.0 0.001408836344877 0.0003969695918337 0.0 0.0 0.0 0.0 991 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1190927 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Apocrine Cells Apocrine Cells -> Apocrine Cells 7.233591842249152e-06 0.0 0.0 1.0 0.0002584008880758 0.0005543771898401 0.0 0.00014415453366 0.0282716464198159 0.0 991 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1190935 MMRN2 CLEC14A MMRN2-CLEC14A Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.6295299164922566e-06 0.9845127857250529 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1190936 MMRN2 CD93 MMRN2-CD93 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.6295299164922566e-06 0.9845127857250529 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1190980 MMP2 PECAM1 MMP2-PECAM1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.607266162447117e-06 0.0 0.956444566971872 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1190982 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.607266162447117e-06 0.0 0.956444566971872 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1190983 CD34 SELP CD34-SELP Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.606877020867352e-06 0.9559599666576516 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1190987 VWF ITGA9 VWF-ITGA9 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.606678715657255e-06 0.955713094717548 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1190990 VWF LRP1 VWF-LRP1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.606678715657255e-06 0.955713094717548 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1190993 VWF SELP VWF-SELP Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.606678715657255e-06 0.955713094717548 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1191102 CCN1 CAV1 CCN1-CAV1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.595725303102173e-06 0.0 0.942159351720962 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1191110 VWF ITGA9 VWF-ITGA9 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.594295709345375e-06 0.0 0.9404022517663844 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1191203 DLL1 NOTCH3 DLL1-NOTCH3 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.590436630481858e-06 0.9356727248601746 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1191252 CD48 CD2 CD48-CD2 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 4.584509650779463e-06 0.928447473463448 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1191277 C1QB LRP1 C1QB-LRP1 Macrophages Unassigned Macrophages -> Unassigned 4.5822349030235535e-06 0.9256868304646206 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1191299 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 4.582132246095704e-06 0.0 0.9255624071030766 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1191377 DLL4 NOTCH3 DLL4-NOTCH3 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.576245188173534e-06 0.9184503888425788 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1191378 DLL4 NOTCH4 DLL4-NOTCH4 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.576245188173534e-06 0.9184503888425788 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1191487 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 4.561484615078762e-06 0.0 0.9008184599638702 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1191495 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.561069316378525e-06 0.0 0.9003264838243337 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1191526 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.557548096342201e-06 0.0 0.896164124004365 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1191533 CD48 CD2 CD48-CD2 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 4.557493258646143e-06 0.0 0.8960994285623033 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1191593 A2M LRP1 A2M-LRP1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.55550120104864e-06 0.8937519114898692 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1191602 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 4.55436141535938e-06 0.8924110508951895 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 29 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1191604 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 4.55436141535938e-06 0.8924110508951895 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 29 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1191711 COL4A2 CD93 COL4A2-CD93 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.54720412909258e-06 0.8840293712888387 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1191732 CD34 SELP CD34-SELP Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.545387637960743e-06 0.0 0.8819126042133903 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1191735 VWF SELP VWF-SELP Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.545387637960743e-06 0.0 0.8819126042133903 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1191742 HSPG2 LRP1 HSPG2-LRP1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.545305096524839e-06 0.8818165186409654 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1191754 COL4A1 CD93 COL4A1-CD93 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.545220820269853e-06 0.0 0.8817184225858201 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1191756 COL4A2 CD93 COL4A2-CD93 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.545220820269853e-06 0.0 0.8817184225858201 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1191758 MMRN2 CD93 MMRN2-CD93 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.545220820269853e-06 0.0 0.8817184225858201 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1191799 VEGFC FLT1 VEGFC-FLT1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.5422398408703975e-06 0.0 0.878254460598671 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1191892 VEGFC FLT1 VEGFC-FLT1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.536677360885093e-06 0.8718210606749883 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1191934 EFNB2 PECAM1 EFNB2-PECAM1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.529927114086592e-06 0.8640667164982425 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1191982 THBS2 CD36 THBS2-CD36 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 4.525275464882104e-06 0.0 0.8587566561291643 0.0 0.0 1.0 0.0 0.0 0.0 0.0 9 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1192610 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 4.466666030784275e-06 0.7941469661104034 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1193108 COL4A1 CD93 COL4A1-CD93 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.450091373943375e-06 0.7766289238087107 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1193125 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 4.449815486654042e-06 0.0 0.7763400818577846 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1193198 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Pericytes Unassigned -> Pericytes 4.438726302669705e-06 0.0 0.8818326005152037 0.0 0.0 0.8672894033034337 0.0 0.0 0.0 0.0 7 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1193201 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Pericytes Unassigned -> Pericytes 4.438726302669705e-06 0.0 0.8818326005152037 0.0 0.0 0.8672894033034337 0.0 0.0 0.0 0.0 7 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1193286 C1QB LRP1 C1QB-LRP1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 4.409046828610024e-06 0.0 0.7346293219749174 0.0 0.0 1.0 0.0 0.0 0.0 0.0 36 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1193288 HSPG2 LRP1 HSPG2-LRP1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 4.409046828610024e-06 0.0 0.7346293219749174 0.0 0.0 1.0 0.0 0.0 0.0 0.0 36 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1193307 VWF LRP1 VWF-LRP1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 4.409046828610024e-06 0.0 0.7346293219749174 0.0 0.0 1.0 0.0 0.0 0.0 0.0 36 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1193320 C3 LRP1 C3-LRP1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 4.409046828610024e-06 0.0 0.7346293219749174 0.0 0.0 1.0 0.0 0.0 0.0 0.0 36 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1193323 A2M LRP1 A2M-LRP1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 4.409046828610024e-06 0.0 0.7346293219749174 0.0 0.0 1.0 0.0 0.0 0.0 0.0 36 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1193385 CCN1 CAV1 CCN1-CAV1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 4.406872431988873e-06 0.7324582304061453 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 29 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1193714 THBS2 CD36 THBS2-CD36 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 4.3988593610624405e-06 0.724503440376099 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 29 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1193871 MMP2 PECAM1 MMP2-PECAM1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 4.393137439422898e-06 0.718867305289982 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 29 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1193923 C3 LRP1 C3-LRP1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 4.38907914058318e-06 0.7148920381722296 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 29 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1193999 C1QB LRP1 C1QB-LRP1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 4.3734990281467815e-06 0.8703788833238396 0.0 0.0 0.8040181448318822 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1194045 CLEC2D KLRB1 CLEC2D-KLRB1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 4.351998894902756e-06 0.7797302331085993 0.0 0.0 0.8713412494740926 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1194541 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 4.334627175135336e-06 0.0 0.663300745568453 0.0 0.0 1.0 0.0 0.0 0.0 0.0 13 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1194999 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 4.331607130067538e-06 0.6605327397359113 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1195622 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 4.328895973792544e-06 0.0 0.6580560501976399 0.0 0.0 1.0 0.0 0.0 0.0 0.0 13 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1195624 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 4.328895973792544e-06 0.0 0.6580560501976399 0.0 0.0 1.0 0.0 0.0 0.0 0.0 13 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1198270 CCN1 CAV1 CCN1-CAV1 Unassigned Pericytes Unassigned -> Pericytes 4.172654668537117e-06 0.0 0.9694036398779844 0.0 0.0 0.5444650460041837 0.0 0.0 0.0 0.0 7 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1198381 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 4.152771827480342e-06 0.7296454584598743 0.0 0.0 0.7029371915698084 0.0 0.0 0.0 0.0 0.0 29 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1198600 COL4A2 CD93 COL4A2-CD93 Pericytes Unassigned Pericytes -> Unassigned 4.121482895623161e-06 0.8840293712888387 0.0 0.0 0.5544396796022323 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1199304 CCN1 CAV1 CCN1-CAV1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 4.012838134771506e-06 0.9219165193585238 0.0 0.0 0.4529166025129413 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1199407 CD48 CD2 CD48-CD2 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 4.003170832514997e-06 0.9011089648206808 0.0 0.0 0.4567172527116189 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1199703 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 3.9638163941321295e-06 0.662063103571249 0.0 0.0 0.585843718590581 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1199820 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 3.9505789690082e-06 0.0 0.8950084308969304 0.0 0.0 0.4247538686915498 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1199892 COL4A1 CD93 COL4A1-CD93 Pericytes Unassigned Pericytes -> Unassigned 3.94547973089456e-06 0.7766289238087107 0.0 0.0 0.4857192596400828 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1200176 COL4A2 CD93 COL4A2-CD93 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 3.908290507980789e-06 0.4630253981438691 0.0 0.0 0.7696906278989153 0.0 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1200553 A2M LRP1 A2M-LRP1 Pericytes Unassigned Pericytes -> Unassigned 3.867454482388104e-06 0.8937519114898692 0.0 0.0 0.3743986430148447 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1201260 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 3.7933292960637694e-06 0.6593525851613742 0.0 0.0 0.4518617096918393 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1201542 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 3.768680627816764e-06 0.0 0.9008184599638702 0.0 0.0 0.3180524283074206 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1201560 COL4A2 CD93 COL4A2-CD93 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 3.767555780520262e-06 0.6582846571368821 0.0 0.0 0.4344545964241579 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1201833 COL4A1 CD93 COL4A1-CD93 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 3.736354590144728e-06 0.6630837220165452 0.0 0.0 0.4103175828613323 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1202769 THBS2 CD36 THBS2-CD36 Unassigned Pericytes Unassigned -> Pericytes 3.676269887759629e-06 0.0 0.8587566561291643 0.0 0.0 0.287457858136305 0.0 0.0 0.0 0.0 7 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1202847 CCN1 CAV1 CCN1-CAV1 Pericytes Unassigned Pericytes -> Unassigned 3.669106430828292e-06 0.9219165193585238 0.0 0.0 0.2646489893253856 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1203047 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 3.6539317058300487e-06 0.0 0.4638256179742202 0.0 0.0 0.5131068416842878 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1203055 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 3.6539317058300487e-06 0.0 0.4638256179742202 0.0 0.0 0.5131068416842878 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1203847 DLL1 NOTCH3 DLL1-NOTCH3 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 3.589796167289538e-06 0.7296454584598743 0.0 0.0 0.293296467876477 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1203918 VWF ITGA9 VWF-ITGA9 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 3.5823338889280344e-06 0.0 0.7292496872084557 0.0 0.0 0.2898144908728011 0.0 0.0 0.0 0.0 6 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1203960 VWF ITGA9 VWF-ITGA9 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 3.578562332390625e-06 0.0 0.7292496872084557 0.0 0.0 0.2879885658616873 0.0 0.0 0.0 0.0 36 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1204017 COL4A1 CD93 COL4A1-CD93 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 3.576875006908846e-06 0.4604235282221027 0.0 0.0 0.454846709299195 0.0 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1204103 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 3.572503130517245e-06 0.0 0.657421674383923 0.0 0.0 0.3162217004298525 0.0 0.0 0.0 0.0 13 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1205808 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 3.480580639301076e-06 0.0 0.7746834992804791 0.0 0.0 0.2295016807597237 0.0 0.0 0.0 0.0 3 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1205811 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 3.480580639301076e-06 0.0 0.7746834992804791 0.0 0.0 0.2295016807597237 0.0 0.0 0.0 0.0 3 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1205987 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 3.4740963497132e-06 0.0 0.8818326005152037 0.0 0.0 0.1993723722552783 0.0 0.0 0.0 0.0 9 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1205989 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 3.4740963497132e-06 0.0 0.8818326005152037 0.0 0.0 0.1993723722552783 0.0 0.0 0.0 0.0 9 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1206122 CCN1 CAV1 CCN1-CAV1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 3.4683796663347257e-06 0.7324582304061453 0.0 0.0 0.2376713873232418 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1206712 CLEC2D KLRB1 CLEC2D-KLRB1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 3.436009449046824e-06 0.4625081978296446 0.0 0.0 0.3558005706994493 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1206749 DLL1 NOTCH3 DLL1-NOTCH3 Pericytes Unassigned Pericytes -> Unassigned 3.4332401027640025e-06 0.9356727248601746 0.0 0.0 0.1750253929104546 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1206877 EFNB2 PECAM1 EFNB2-PECAM1 Pericytes Unassigned Pericytes -> Unassigned 3.429450523269514e-06 0.8640667164982425 0.0 0.0 0.1882781599600688 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1207313 VEGFC FLT1 VEGFC-FLT1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 3.4113608095098784e-06 0.0 0.6593689120110077 0.0 0.0 0.2390217618875283 0.0 0.0 0.0 0.0 13 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1207381 VEGFC FLT1 VEGFC-FLT1 Pericytes Unassigned Pericytes -> Unassigned 3.4077796443658302e-06 0.8718210606749883 0.0 0.0 0.1796394187986057 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1207735 HSPG2 LRP1 HSPG2-LRP1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 3.395411391767544e-06 0.4629984640915818 0.0 0.0 0.3309594876493178 0.0 0.0 0.0 0.0 0.0 29 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1208028 MMP2 PECAM1 MMP2-PECAM1 Unassigned Pericytes Unassigned -> Pericytes 3.3842869663129044e-06 0.0 0.930308383061206 0.0 0.0 0.1615013370958009 0.0 0.0 0.0 0.0 7 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1208029 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Pericytes Unassigned -> Pericytes 3.3842869663129044e-06 0.0 0.930308383061206 0.0 0.0 0.1615013370958009 0.0 0.0 0.0 0.0 7 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1208036 COL4A2 CD93 COL4A2-CD93 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 3.3838975063415906e-06 0.7783550150988336 0.0 0.0 0.1928969878996252 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1208604 HSPG2 LRP1 HSPG2-LRP1 Pericytes Unassigned Pericytes -> Unassigned 3.3556307453724744e-06 0.8818165186409654 0.0 0.0 0.1619074107723045 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1208949 CCN1 CAV1 CCN1-CAV1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 3.343143775266846e-06 0.6213271600240247 0.0 0.0 0.2247035641022029 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1209229 A2M LRP1 A2M-LRP1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 3.336256654611039e-06 0.4648000335061383 0.0 0.0 0.2966815529783992 0.0 0.0 0.0 0.0 0.0 29 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1209514 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 3.324431126716847e-06 0.6249837837987587 0.0 0.0 0.2159908053119969 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1210051 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 3.303182108100208e-06 0.0 0.6580560501976399 0.0 0.0 0.1973932010691654 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1210053 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 3.303182108100208e-06 0.0 0.6580560501976399 0.0 0.0 0.1973932010691654 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1210114 A2M LRP1 A2M-LRP1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 3.301007808875109e-06 0.7741139100414175 0.0 0.0 0.1671376945154473 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1210390 VWF ITGA9 VWF-ITGA9 Unassigned Pericytes Unassigned -> Pericytes 3.289454186977626e-06 0.0 0.9404022517663844 0.0 0.0 0.1347191569099048 0.0 0.0 0.0 0.0 7 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1210928 CD34 SELP CD34-SELP Pericytes Unassigned Pericytes -> Unassigned 3.27020115475892e-06 0.9303167350027568 0.0 0.0 0.1314667522621683 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1211146 HSPG2 LRP1 HSPG2-LRP1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 3.264600396379123e-06 0.6589792304505506 0.0 0.0 0.1836996873148393 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1211210 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Pericytes Unassigned -> Pericytes 3.2634340674491405e-06 0.0 0.9003264838243337 0.0 0.0 0.1341680150528327 0.0 0.0 0.0 0.0 7 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1211226 THBS2 CD36 THBS2-CD36 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 3.2626933267108024e-06 0.6242573126045354 0.0 0.0 0.1932385901170197 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1211599 VWF ITGA9 VWF-ITGA9 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 3.250463103881086e-06 0.0 0.6252253442669611 0.0 0.0 0.1886404570313 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1211628 COL4A2 CD93 COL4A2-CD93 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 3.2500619599925504e-06 0.4630253981438691 0.0 0.0 0.2545335314555431 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1211702 VWF LRP1 VWF-LRP1 Pericytes Unassigned Pericytes -> Unassigned 3.247100179734518e-06 0.9275752708651288 0.0 0.0 0.1263644540569636 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1211705 VWF ITGA9 VWF-ITGA9 Pericytes Unassigned Pericytes -> Unassigned 3.247100179734518e-06 0.9275752708651288 0.0 0.0 0.1263644540569636 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1211706 VWF SELP VWF-SELP Pericytes Unassigned Pericytes -> Unassigned 3.247100179734518e-06 0.9275752708651288 0.0 0.0 0.1263644540569636 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1211744 VEGFC FLT1 VEGFC-FLT1 Unassigned Pericytes Unassigned -> Pericytes 3.246118384541898e-06 0.0 0.878254460598671 0.0 0.0 0.1332188634280341 0.0 0.0 0.0 0.0 7 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1212093 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 3.2347899920521794e-06 0.6582846571368821 0.0 0.0 0.1740454925211078 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1212319 MMRN2 CD93 MMRN2-CD93 Unassigned Pericytes Unassigned -> Pericytes 3.22740304278025e-06 0.0 0.8817184225858201 0.0 0.0 0.1281708518900828 0.0 0.0 0.0 0.0 7 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1212321 COL4A1 CD93 COL4A1-CD93 Unassigned Pericytes Unassigned -> Pericytes 3.22740304278025e-06 0.0 0.8817184225858201 0.0 0.0 0.1281708518900828 0.0 0.0 0.0 0.0 7 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1212322 COL4A2 CD93 COL4A2-CD93 Unassigned Pericytes Unassigned -> Pericytes 3.22740304278025e-06 0.0 0.8817184225858201 0.0 0.0 0.1281708518900828 0.0 0.0 0.0 0.0 7 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1213215 DLL4 NOTCH4 DLL4-NOTCH4 Pericytes Unassigned Pericytes -> Unassigned 3.200168305797677e-06 0.9184503888425788 0.0 0.0 0.1169448695751571 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1213218 DLL4 NOTCH3 DLL4-NOTCH3 Pericytes Unassigned Pericytes -> Unassigned 3.200168305797677e-06 0.9184503888425788 0.0 0.0 0.1169448695751571 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1213432 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 3.193858026153056e-06 0.0 0.6571792026963191 0.0 0.0 0.1615138601457002 0.0 0.0 0.0 0.0 13 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1213438 MMRN2 CD93 MMRN2-CD93 Pericytes Unassigned Pericytes -> Unassigned 3.1934273153157767e-06 0.9468422434493456 0.0 0.0 0.1120119983652299 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1213440 MMRN2 CLEC14A MMRN2-CLEC14A Pericytes Unassigned Pericytes -> Unassigned 3.1934273153157767e-06 0.9468422434493456 0.0 0.0 0.1120119983652299 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1213467 EFNB2 PECAM1 EFNB2-PECAM1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 3.192643373442145e-06 0.7800321422220979 0.0 0.0 0.1357656553382984 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1213549 CCN1 CAV1 CCN1-CAV1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 3.191085517832924e-06 0.0 0.7283139964676212 0.0 0.0 0.1449812920932466 0.0 0.0 0.0 0.0 36 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1213864 DLL1 NOTCH3 DLL1-NOTCH3 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 3.1821017849690897e-06 0.6249837837987587 0.0 0.0 0.1661175896787547 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1213936 A2M LRP1 A2M-LRP1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 3.181209412844829e-06 0.0 0.6207977546603366 0.0 0.0 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1213953 VWF LRP1 VWF-LRP1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 3.181209412844829e-06 0.0 0.6207977546603366 0.0 0.0 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1213954 HSPG2 LRP1 HSPG2-LRP1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 3.181209412844829e-06 0.0 0.6207977546603366 0.0 0.0 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1213960 C3 LRP1 C3-LRP1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 3.181209412844829e-06 0.0 0.6207977546603366 0.0 0.0 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1213961 C1QB LRP1 C1QB-LRP1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 3.181209412844829e-06 0.0 0.6207977546603366 0.0 0.0 0.166956519448744 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1214853 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 3.1605117930368078e-06 0.6659645551150886 0.0 0.0 0.1496557267835524 0.0 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1215266 A2M LRP1 A2M-LRP1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 3.1496225892283863e-06 0.4648000335061383 0.0 0.0 0.2100317344087863 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1215376 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 3.1463819992280184e-06 0.6605327397359113 0.0 0.0 0.1468839381042521 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1216364 VWF ITGA9 VWF-ITGA9 Unassigned Macrophages Unassigned -> Macrophages 3.1204019757343253e-06 0.0 0.8794572885381431 0.0 0.0 0.104965956217838 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1217179 MMP2 PECAM1 MMP2-PECAM1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 3.102768505772467e-06 0.6303642896310324 0.0 0.0 0.141548283585814 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1217390 CLEC2D KLRB1 CLEC2D-KLRB1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 3.097180256697273e-06 0.7797302331085993 0.0 0.0 0.1132020978253244 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1218074 CCN1 CAV1 CCN1-CAV1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 3.081927843893799e-06 0.0 0.7283139964676212 0.0 0.0 0.1176565474247238 0.0 0.0 0.0 0.0 6 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1218497 CD34 SELP CD34-SELP CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 3.07224985094026e-06 0.7168245244832976 0.0 0.0 0.1173076386135379 0.0 0.0 0.0 0.0 0.0 29 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1218783 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 3.067030400068988e-06 0.6213271600240247 0.0 0.0 0.1339639999453202 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1220856 CXCL12 ITGA4 CXCL12-ITGA4 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 3.026920919151115e-06 0.7487535481622718 0.0 0.0 0.1027229557481577 0.0 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1220864 CXCL12 CXCR4 CXCL12-CXCR4 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 3.026920919151115e-06 0.7487535481622718 0.0 0.0 0.1027229557481577 0.0 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1220930 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Pericytes Unassigned -> Pericytes 3.0254621104509176e-06 0.0 0.896164124004365 0.0 0.0 0.0855781119790033 0.0 0.0 0.0 0.0 7 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1221023 THBS2 CD36 THBS2-CD36 Unassigned Macrophages Unassigned -> Macrophages 3.0228853877042706e-06 0.0 0.8587566561291643 0.0 0.0 0.088850508457521 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1221565 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 3.0092984526453366e-06 0.0 0.4614667734221426 0.0 0.0 0.1609352200462838 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1221778 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 3.0050675602037143e-06 0.6561647292424944 0.0 0.0 0.112230917768503 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1222270 A2M LRP1 A2M-LRP1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.9957874025953697e-06 0.7741139100414175 0.0 0.0 0.093381536992618 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1222405 A2M LRP1 A2M-LRP1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.9945606897508537e-06 0.6561647292424944 0.0 0.0 0.1098969873322313 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1222543 CCN1 CAV1 CCN1-CAV1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.99134532462736e-06 0.6213271600240247 0.0 0.0 0.1153131738111426 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1223204 VWF ITGA9 VWF-ITGA9 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.9765790579843486e-06 0.0 0.6252253442669611 0.0 0.0 0.1112417752963437 0.0 0.0 0.0 0.0 13 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1223321 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.9743897705047023e-06 0.4625081978296446 0.0 0.0 0.149715856631667 0.0 0.0 0.0 0.0 0.0 29 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1224666 VWF SELP VWF-SELP Unassigned Pericytes Unassigned -> Pericytes 2.945849283961401e-06 0.0 0.8819126042133903 0.0 0.0 0.0741032966028748 0.0 0.0 0.0 0.0 7 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1224668 CD34 SELP CD34-SELP Unassigned Pericytes Unassigned -> Pericytes 2.945849283961401e-06 0.0 0.8819126042133903 0.0 0.0 0.0741032966028748 0.0 0.0 0.0 0.0 7 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1225243 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.93655186569612e-06 0.0 0.7754072541855492 0.0 0.0 0.0826982152707935 0.0 0.0 0.0 0.0 3 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1225311 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.935784275128728e-06 0.662063103571249 0.0 0.0 0.0967042147306326 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1225462 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.932781107430617e-06 0.0 0.4641352222874551 0.0 0.0 0.1370986982961073 0.0 0.0 0.0 0.0 6 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1226961 COL4A1 CD93 COL4A1-CD93 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.9062207453617152e-06 0.8533682807143209 0.0 0.0 0.0706049302656684 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1227261 CD48 CD2 CD48-CD2 B Cells Unassigned B Cells -> Unassigned 2.9013551730985216e-06 0.9426443637490616 0.0 0.0 0.0632786830726401 0.0 0.0 0.0 0.0 0.0 2 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1227694 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.8931910243988324e-06 0.0 0.4614667734221426 0.0 0.0 0.12709315903692 0.0 0.0 0.0 0.0 36 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1229411 EFNB2 PECAM1 EFNB2-PECAM1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.86381758644243e-06 0.4619393085577573 0.0 0.0 0.1194227711616854 0.0 0.0 0.0 0.0 0.0 29 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1229654 CLEC2D KLRB1 CLEC2D-KLRB1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.8580968697888187e-06 0.7797302331085993 0.0 0.0 0.0699064461360958 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1229826 VWF ITGA9 VWF-ITGA9 Unassigned Mast Cells Unassigned -> Mast Cells 2.854703814448995e-06 0.0 0.863034163938375 0.0 0.0 0.0627102121186242 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1229932 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.853142093033982e-06 0.0 0.8891607331132086 0.0 0.0 0.0606680526002441 0.0 0.0 0.0 0.0 3 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1230306 DLL1 NOTCH3 DLL1-NOTCH3 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.846871420965408e-06 0.2534163760166434 0.0 0.0 0.2100740470724093 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1231560 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.8232800147837184e-06 0.633566764858408 0.0 0.0 0.0799339500711946 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1232198 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.812203062674972e-06 0.0 0.4596166826058663 0.0 0.0 0.1076178292491983 0.0 0.0 0.0 0.0 36 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1232490 MMRN2 CD93 MMRN2-CD93 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.8062843754886155e-06 0.0 0.7779918296243433 0.0 0.0 0.0627790816848129 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1232497 COL4A2 CD93 COL4A2-CD93 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.8062843754886155e-06 0.0 0.7779918296243433 0.0 0.0 0.0627790816848129 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1232499 COL4A1 CD93 COL4A1-CD93 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.8062843754886155e-06 0.0 0.7779918296243433 0.0 0.0 0.0627790816848129 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1233050 CXCL12 ITGA4 CXCL12-ITGA4 Pericytes Unassigned Pericytes -> Unassigned 2.795411796384e-06 0.7487535481622718 0.0 0.0 0.0637288077574987 0.0 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1233052 CXCL12 CXCR4 CXCL12-CXCR4 Pericytes Unassigned Pericytes -> Unassigned 2.795411796384e-06 0.7487535481622718 0.0 0.0 0.0637288077574987 0.0 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1234094 COL4A1 CD93 COL4A1-CD93 Unassigned Macrophages Unassigned -> Macrophages 2.7754733145406437e-06 0.0 0.944024288971064 0.0 0.0 0.0484215930647349 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1234101 COL4A2 CD93 COL4A2-CD93 Unassigned Macrophages Unassigned -> Macrophages 2.7754733145406437e-06 0.0 0.944024288971064 0.0 0.0 0.0484215930647349 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1234104 MMRN2 CD93 MMRN2-CD93 Unassigned Macrophages Unassigned -> Macrophages 2.7754733145406437e-06 0.0 0.944024288971064 0.0 0.0 0.0484215930647349 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1235260 C3 LRP1 C3-LRP1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.7550205259955548e-06 0.6319926036888139 0.0 0.0 0.0691889863216023 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1235332 CCN1 CAV1 CCN1-CAV1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.7527136159723623e-06 0.2542249848376565 0.0 0.0 0.1711385759005754 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1235670 CLEC2D KLRB1 CLEC2D-KLRB1 Macrophages Unassigned Macrophages -> Unassigned 2.7464294751506816e-06 0.8978557803479422 0.0 0.0 0.0477973731763516 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1235811 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.744211381435745e-06 0.6342079770588467 0.0 0.0 0.0673400749834054 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1235812 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.744211381435745e-06 0.6342079770588467 0.0 0.0 0.0673400749834054 0.0 0.0 0.0 0.0 0.0 5 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1235886 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.742941340945756e-06 0.0 0.4642836810638544 0.0 0.0 0.0917308979735958 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1235904 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned B Cells Unassigned -> B Cells 2.7425743677594075e-06 0.0 0.9546923450729716 0.0 0.0 0.0445745465878424 0.0 0.0 0.0 0.0 2 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1236250 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 2.7344068931639377e-06 0.7941469661104034 0.0 0.0 0.0526353932596327 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1237079 CCN1 CAV1 CCN1-CAV1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 2.7203935754399467e-06 0.0 0.62431395375366 0.0 0.0 0.0649213179279442 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1237136 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Macrophages Unassigned -> Macrophages 2.719142044550921e-06 0.0 0.7754239189773715 0.0 0.0 0.0521257226458961 0.0 0.0 0.0 0.0 4 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1237366 CCN1 CAV1 CCN1-CAV1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.7151487032803758e-06 0.0 0.62431395375366 0.0 0.0 0.0641739251983978 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1237493 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 2.7130877886559627e-06 0.0 0.6580560501976399 0.0 0.0 0.0606066271159369 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1237495 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 2.7130877886559627e-06 0.0 0.6580560501976399 0.0 0.0 0.0606066271159369 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1237508 CCN1 CAV1 CCN1-CAV1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.712738712540421e-06 0.0 0.62431395375366 0.0 0.0 0.0638329144736252 0.0 0.0 0.0 0.0 13 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1237822 JAG1 NOTCH2 JAG1-NOTCH2 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.7053864942743653e-06 0.9097736029185508 0.0 0.0 0.0430965463818576 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1237956 C3 LRP1 C3-LRP1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.7027841071673875e-06 0.6319926036888139 0.0 0.0 0.0616816618657801 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1238175 COL4A1 CD93 COL4A1-CD93 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.6990402133040204e-06 0.4604235282221027 0.0 0.0 0.0839650520556947 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1238235 EFNB2 PECAM1 EFNB2-PECAM1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.698175424997469e-06 0.4619393085577573 0.0 0.0 0.0835287751665837 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1238377 HSPG2 LRP1 HSPG2-LRP1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.6956836205828025e-06 0.7789175740361626 0.0 0.0 0.0492631209980634 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1238490 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Macrophages Unassigned -> Macrophages 2.6930409697275964e-06 0.0 0.7757991160529997 0.0 0.0 0.0491709261488903 0.0 0.0 0.0 0.0 4 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1238848 C1QB LRP1 C1QB-LRP1 Unassigned Macrophages Unassigned -> Macrophages 2.68554586399036e-06 0.0 0.8604147465201248 0.0 0.0 0.0436001007095475 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1238860 VWF LRP1 VWF-LRP1 Unassigned Macrophages Unassigned -> Macrophages 2.68554586399036e-06 0.0 0.8604147465201248 0.0 0.0 0.0436001007095475 0.0 0.0 0.0 0.0 4 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1238863 A2M LRP1 A2M-LRP1 Unassigned Macrophages Unassigned -> Macrophages 2.68554586399036e-06 0.0 0.8604147465201248 0.0 0.0 0.0436001007095475 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1238867 C3 LRP1 C3-LRP1 Unassigned Macrophages Unassigned -> Macrophages 2.68554586399036e-06 0.0 0.8604147465201248 0.0 0.0 0.0436001007095475 0.0 0.0 0.0 0.0 4 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1238883 HSPG2 LRP1 HSPG2-LRP1 Unassigned Macrophages Unassigned -> Macrophages 2.68554586399036e-06 0.0 0.8604147465201248 0.0 0.0 0.0436001007095475 0.0 0.0 0.0 0.0 4 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1239013 MMP2 PECAM1 MMP2-PECAM1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 2.682738975754732e-06 0.9067635403815892 0.0 0.0 0.0411127335336962 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1239215 CLEC2D KLRB1 CLEC2D-KLRB1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 2.680402644533381e-06 0.8721681415062816 0.0 0.0 0.0425206505665654 0.0 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1239282 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.67932871323128e-06 0.6589792304505506 0.0 0.0 0.0561415215593491 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1239593 C1QB LRP1 C1QB-LRP1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.6736816509666747e-06 0.8703788833238396 0.0 0.0 0.0419710388788557 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1239678 C3 LRP1 C3-LRP1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.6727322798839125e-06 0.0 0.6207977546603366 0.0 0.0 0.0587195251380622 0.0 0.0 0.0 0.0 13 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1239688 HSPG2 LRP1 HSPG2-LRP1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.6727322798839125e-06 0.0 0.6207977546603366 0.0 0.0 0.0587195251380622 0.0 0.0 0.0 0.0 13 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1239692 C1QB LRP1 C1QB-LRP1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.6727322798839125e-06 0.0 0.6207977546603366 0.0 0.0 0.0587195251380622 0.0 0.0 0.0 0.0 13 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1239700 A2M LRP1 A2M-LRP1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.6727322798839125e-06 0.0 0.6207977546603366 0.0 0.0 0.0587195251380622 0.0 0.0 0.0 0.0 13 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1239704 VWF LRP1 VWF-LRP1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.6727322798839125e-06 0.0 0.6207977546603366 0.0 0.0 0.0587195251380622 0.0 0.0 0.0 0.0 13 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1239795 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned B Cells Unassigned -> B Cells 2.6710338339756097e-06 0.0 0.7763400818577846 0.0 0.0 0.0467761235673353 0.0 0.0 0.0 0.0 2 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1240328 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned B Cells Unassigned -> B Cells 2.662102908522845e-06 0.0 0.9460955677032749 0.0 0.0 0.0376195773145198 0.0 0.0 0.0 0.0 2 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1240470 VWF ITGA9 VWF-ITGA9 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 2.659512437179956e-06 0.0 0.6252253442669611 0.0 0.0 0.0565946652887153 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1240491 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.659015356177785e-06 0.0 0.4642836810638544 0.0 0.0 0.0761275033764692 0.0 0.0 0.0 0.0 36 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1240613 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.657500796245782e-06 0.0 0.6347970925105053 0.0 0.0 0.0554888093272979 0.0 0.0 0.0 0.0 13 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1241157 A2M LRP1 A2M-LRP1 Macrophages Unassigned Macrophages -> Unassigned 2.646641735044674e-06 0.919551140852988 0.0 0.0 0.037376181609614 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1241221 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.644299272805129e-06 0.6626993710110988 0.0 0.0 0.0515877972474039 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1241514 CXCL12 ITGA4 CXCL12-ITGA4 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.6387790903505643e-06 0.6160088550075702 0.0 0.0 0.0548063857429699 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1241517 CXCL12 CXCR4 CXCL12-CXCR4 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.6387790903505643e-06 0.6160088550075702 0.0 0.0 0.0548063857429699 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1241689 THBS2 CD36 THBS2-CD36 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.636163442546408e-06 0.0 0.7373999388878224 0.0 0.0 0.0455125113141721 0.0 0.0 0.0 0.0 36 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1242116 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.6288571005596213e-06 0.0 0.6632137581773894 0.0 0.0 0.049767778498468 0.0 0.0 0.0 0.0 13 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1242233 MMP2 PECAM1 MMP2-PECAM1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.626833178701508e-06 0.0 0.6331674633943454 0.0 0.0 0.0518891167572028 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1242236 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.626833178701508e-06 0.0 0.6331674633943454 0.0 0.0 0.0518891167572028 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1242475 CLEC2D KLRB1 CLEC2D-KLRB1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.622966445504791e-06 0.4625081978296446 0.0 0.0 0.0704104148800194 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1242500 JAG1 NOTCH2 JAG1-NOTCH2 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.622667596623687e-06 0.2451358214448441 0.0 0.0 0.1327555461750915 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1242508 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 2.6224552383467862e-06 0.662063103571249 0.0 0.0 0.0491302556793708 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1242740 VEGFC FLT1 VEGFC-FLT1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.6173493756905165e-06 0.4636527906642655 0.0 0.0 0.0693389464442948 0.0 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1242910 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.614860771676621e-06 0.0 0.4638256179742202 0.0 0.0 0.0689186266365139 0.0 0.0 0.0 0.0 36 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1242913 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.614860771676621e-06 0.0 0.4638256179742202 0.0 0.0 0.0689186266365139 0.0 0.0 0.0 0.0 36 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1243080 A2M LRP1 A2M-LRP1 Unassigned Pericytes Unassigned -> Pericytes 2.612401769379916e-06 0.0 0.9078204025796472 0.0 0.0 0.0350138403862125 0.0 0.0 0.0 0.0 7 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1243094 VWF LRP1 VWF-LRP1 Unassigned Pericytes Unassigned -> Pericytes 2.612401769379916e-06 0.0 0.9078204025796472 0.0 0.0 0.0350138403862125 0.0 0.0 0.0 0.0 7 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1243096 C3 LRP1 C3-LRP1 Unassigned Pericytes Unassigned -> Pericytes 2.612401769379916e-06 0.0 0.9078204025796472 0.0 0.0 0.0350138403862125 0.0 0.0 0.0 0.0 7 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1243108 C1QB LRP1 C1QB-LRP1 Unassigned Pericytes Unassigned -> Pericytes 2.612401769379916e-06 0.0 0.9078204025796472 0.0 0.0 0.0350138403862125 0.0 0.0 0.0 0.0 7 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1243113 HSPG2 LRP1 HSPG2-LRP1 Unassigned Pericytes Unassigned -> Pericytes 2.612401769379916e-06 0.0 0.9078204025796472 0.0 0.0 0.0350138403862125 0.0 0.0 0.0 0.0 7 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1243250 HSPG2 LRP1 HSPG2-LRP1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.610546255435542e-06 0.4629984640915818 0.0 0.0 0.0683610513379333 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1243592 HSPG2 LRP1 HSPG2-LRP1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.603559145696777e-06 0.0 0.6207977546603366 0.0 0.0 0.0501711964086628 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1243599 VWF LRP1 VWF-LRP1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.603559145696777e-06 0.0 0.6207977546603366 0.0 0.0 0.0501711964086628 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1243607 C1QB LRP1 C1QB-LRP1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.603559145696777e-06 0.0 0.6207977546603366 0.0 0.0 0.0501711964086628 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1243618 C3 LRP1 C3-LRP1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.603559145696777e-06 0.0 0.6207977546603366 0.0 0.0 0.0501711964086628 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1243627 A2M LRP1 A2M-LRP1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.603559145696777e-06 0.0 0.6207977546603366 0.0 0.0 0.0501711964086628 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1243814 VEGFC FLT1 VEGFC-FLT1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.60005395587711e-06 0.4636527906642655 0.0 0.0 0.0666348171285698 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1244012 HSPG2 LRP1 HSPG2-LRP1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.59546929212839e-06 0.0 0.7346293219749174 0.0 0.0 0.0416128058995347 0.0 0.0 0.0 0.0 6 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1244013 C3 LRP1 C3-LRP1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.59546929212839e-06 0.0 0.7346293219749174 0.0 0.0 0.0416128058995347 0.0 0.0 0.0 0.0 6 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1244017 C1QB LRP1 C1QB-LRP1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.59546929212839e-06 0.0 0.7346293219749174 0.0 0.0 0.0416128058995347 0.0 0.0 0.0 0.0 6 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1244028 A2M LRP1 A2M-LRP1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.59546929212839e-06 0.0 0.7346293219749174 0.0 0.0 0.0416128058995347 0.0 0.0 0.0 0.0 6 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1244042 VWF LRP1 VWF-LRP1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.59546929212839e-06 0.0 0.7346293219749174 0.0 0.0 0.0416128058995347 0.0 0.0 0.0 0.0 6 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1244104 VWF ITGA9 VWF-ITGA9 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.5943174561481512e-06 0.0 0.6252253442669611 0.0 0.0 0.0487643047611538 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1245049 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 2.578651994510619e-06 0.0 0.885766439573873 0.0 0.0 0.0331922776397286 0.0 0.0 0.0 0.0 9 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1245137 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.5766320267072094e-06 0.0 0.8628183098412396 0.0 0.0 0.0339152418223636 0.0 0.0 0.0 0.0 3 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1246601 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.551261727690558e-06 0.6630837220165452 0.0 0.0 0.0415873844357376 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1246904 DLL1 NOTCH3 DLL1-NOTCH3 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.5453393593136887e-06 0.6249837837987587 0.0 0.0 0.0435116250366991 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1246968 VWF SELP VWF-SELP Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.5446064764775694e-06 0.0 0.6572093097629401 0.0 0.0 0.04130664769978 0.0 0.0 0.0 0.0 13 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1246971 CD34 SELP CD34-SELP Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.5446064764775694e-06 0.0 0.6572093097629401 0.0 0.0 0.04130664769978 0.0 0.0 0.0 0.0 13 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1247072 C1QB LRP1 C1QB-LRP1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.5429520190312934e-06 0.4601010570874773 0.0 0.0 0.0587727051993296 0.0 0.0 0.0 0.0 0.0 29 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1247758 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 2.5286062388783022e-06 0.0 0.657421674383923 0.0 0.0 0.0397596998227057 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1247832 CD34 SELP CD34-SELP Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.527505216896304e-06 0.0 0.7760344326192508 0.0 0.0 0.0335947364052305 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1247833 VWF SELP VWF-SELP Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.527505216896304e-06 0.0 0.7760344326192508 0.0 0.0 0.0335947364052305 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1247912 MMP2 PECAM1 MMP2-PECAM1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.525928382098398e-06 0.718867305289982 0.0 0.0 0.0361307801045652 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1247966 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.5249373836574224e-06 0.0 0.6631822525600675 0.0 0.0 0.0390724515618796 0.0 0.0 0.0 0.0 13 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1248025 CD48 CD2 CD48-CD2 Unassigned B Cells Unassigned -> B Cells 2.523974529942078e-06 0.0 0.937587088419394 0.0 0.0 0.0275738893167071 0.0 0.0 0.0 0.0 2 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1248168 DLL1 NOTCH3 DLL1-NOTCH3 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.521484459571908e-06 0.6249837837987587 0.0 0.0 0.0411214967239829 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1248223 JAG1 NOTCH2 JAG1-NOTCH2 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 2.520821633136757e-06 0.7941469661104034 0.0 0.0 0.0323110954490285 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1248535 CXCL12 ITGA4 CXCL12-ITGA4 Macrophages Unassigned Macrophages -> Unassigned 2.516095077308556e-06 0.7487535481622718 0.0 0.0 0.0338862305197021 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1248541 CXCL12 CXCR4 CXCL12-CXCR4 Macrophages Unassigned Macrophages -> Unassigned 2.516095077308556e-06 0.7487535481622718 0.0 0.0 0.0338862305197021 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1249086 VEGFC FLT1 VEGFC-FLT1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.506077426042919e-06 0.0 0.777821334064334 0.0 0.0 0.0318483483218543 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1249120 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 2.5056354991685006e-06 0.0 0.663300745568453 0.0 0.0 0.0373075519081129 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1249196 COL4A2 CD93 COL4A2-CD93 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.5041513756471467e-06 0.7783550150988336 0.0 0.0 0.0316800311254893 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1249671 VEGFC FLT1 VEGFC-FLT1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.4953380709539458e-06 0.0 0.4630488285702799 0.0 0.0 0.0521374123931907 0.0 0.0 0.0 0.0 36 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1249901 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 2.4903556298404157e-06 0.0 0.6580560501976399 0.0 0.0 0.0362497659817488 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1249902 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 2.4903556298404157e-06 0.0 0.6580560501976399 0.0 0.0 0.0362497659817488 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1250362 MMP2 PECAM1 MMP2-PECAM1 Unassigned Plasma Cells Unassigned -> Plasma Cells 2.4826282284699712e-06 0.0 0.7167436199046466 0.0 0.0 0.0326667674102811 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1250363 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Plasma Cells Unassigned -> Plasma Cells 2.4826282284699712e-06 0.0 0.7167436199046466 0.0 0.0 0.0326667674102811 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1251027 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.472099543038284e-06 0.0 0.7763400818577846 0.0 0.0 0.0293997450046583 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1251117 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Pericytes Unassigned -> Pericytes 2.4702582976070576e-06 0.0 0.7754239189773715 0.0 0.0 0.0293031867940321 0.0 0.0 0.0 0.0 7 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1251508 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Plasma Cells Unassigned -> Plasma Cells 2.46238160182723e-06 0.0 0.4596166826058663 0.0 0.0 0.0484993884807927 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1251535 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Macrophages Unassigned -> Macrophages 2.46193646003535e-06 0.0 0.9015117569158254 0.0 0.0 0.0246995741084876 0.0 0.0 0.0 0.0 4 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1251536 MMP2 PECAM1 MMP2-PECAM1 Unassigned Macrophages Unassigned -> Macrophages 2.46193646003535e-06 0.0 0.9015117569158254 0.0 0.0 0.0246995741084876 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1252014 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.455238480096725e-06 0.0 0.8622452992050237 0.0 0.0 0.0254056950469408 0.0 0.0 0.0 0.0 3 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1252144 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.453309320611769e-06 0.0 0.4641352222874551 0.0 0.0 0.046975263367762 0.0 0.0 0.0 0.0 36 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1252338 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 2.4511846188501266e-06 0.0 0.7757991160529997 0.0 0.0 0.0279580382843415 0.0 0.0 0.0 0.0 9 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1252407 JAG1 NOTCH2 JAG1-NOTCH2 Pericytes Unassigned Pericytes -> Unassigned 2.4493726604981915e-06 0.6303682835571691 0.0 0.0 0.0342558468646473 0.0 0.0 0.0 0.0 0.0 5 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1252516 CD48 CD2 CD48-CD2 Plasma Cells Unassigned Plasma Cells -> Unassigned 2.446758816981288e-06 0.4593282471594782 0.0 0.0 0.0467114894617178 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1252864 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.440405827243741e-06 0.0 0.4641352222874551 0.0 0.0 0.0455121851821151 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1252876 C3 LRP1 C3-LRP1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.4402441021179638e-06 0.6319926036888139 0.0 0.0 0.0334108479684367 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1253071 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.4369941796581e-06 0.0 0.7154802332407408 0.0 0.0 0.0292771742399634 0.0 0.0 0.0 0.0 36 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1253180 COL4A2 CD93 COL4A2-CD93 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.434681277618137e-06 0.7783550150988336 0.0 0.0 0.0267593032157803 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1253451 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.4322792811900616e-06 0.0 0.4638256179742202 0.0 0.0 0.0446401662952339 0.0 0.0 0.0 0.0 6 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1253455 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.4322792811900616e-06 0.0 0.4638256179742202 0.0 0.0 0.0446401662952339 0.0 0.0 0.0 0.0 6 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1253497 MMP2 PECAM1 MMP2-PECAM1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.4315374054079065e-06 0.0 0.6331674633943454 0.0 0.0 0.0326412663903893 0.0 0.0 0.0 0.0 13 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1253499 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.4315374054079065e-06 0.0 0.6331674633943454 0.0 0.0 0.0326412663903893 0.0 0.0 0.0 0.0 13 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1253582 CD48 CD2 CD48-CD2 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.430249707469463e-06 0.0 0.8960994285623033 0.0 0.0 0.0229905310518441 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1253654 COL4A2 CD93 COL4A2-CD93 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.4287910979761552e-06 0.4630253981438691 0.0 0.0 0.0443339118517084 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1254591 MMP2 PECAM1 MMP2-PECAM1 Pericytes Unassigned Pericytes -> Unassigned 2.410950972139597e-06 0.9067635403815892 0.0 0.0 0.0216588811659259 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1254849 VWF ITGA9 VWF-ITGA9 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.40558276616125e-06 0.0 0.6252253442669611 0.0 0.0 0.0309945332907452 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1255250 COL4A2 CD93 COL4A2-CD93 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.3990981548437866e-06 0.0 0.6587114738285964 0.0 0.0 0.0289462771086338 0.0 0.0 0.0 0.0 13 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1255254 COL4A1 CD93 COL4A1-CD93 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.3990981548437866e-06 0.0 0.6587114738285964 0.0 0.0 0.0289462771086338 0.0 0.0 0.0 0.0 13 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1255256 MMRN2 CD93 MMRN2-CD93 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.3990981548437866e-06 0.0 0.6587114738285964 0.0 0.0 0.0289462771086338 0.0 0.0 0.0 0.0 13 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1255467 CD34 SELP CD34-SELP CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.395696109161608e-06 0.633566764858408 0.0 0.0 0.0298399317533219 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1255630 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.3917894102679894e-06 0.0 0.4642836810638544 0.0 0.0 0.040323117011325 0.0 0.0 0.0 0.0 6 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1255850 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.3872792811119724e-06 0.0 0.7754072541855492 0.0 0.0 0.0238720285974944 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1255937 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.385291090887924e-06 0.0 0.8445107771175474 0.0 0.0 0.0218093597373452 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1255970 JAG1 NOTCH2 JAG1-NOTCH2 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 2.384758994091947e-06 0.6303682835571691 0.0 0.0 0.0291791383241764 0.0 0.0 0.0 0.0 0.0 5 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1256750 THBS2 CD36 THBS2-CD36 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.3703035856612623e-06 0.0 0.6176321640000088 0.0 0.0 0.02871400543887 0.0 0.0 0.0 0.0 13 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1256798 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 2.3699962464882924e-06 0.0 0.6631822525600675 0.0 0.0 0.0267210109213584 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1256975 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 2.367530159482053e-06 0.0 0.663300745568453 0.0 0.0 0.0265498740402422 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1257030 THBS2 CD36 THBS2-CD36 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.366059604296436e-06 0.0 0.6176321640000088 0.0 0.0 0.0284069116891947 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1257323 VEGFC FLT1 VEGFC-FLT1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 2.361581552695237e-06 0.0 0.6593689120110077 0.0 0.0 0.026308073552735 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1257500 JAG1 NOTCH2 JAG1-NOTCH2 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.35779003241415e-06 0.6303682835571691 0.0 0.0 0.0272543760657653 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1257619 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.354477753658633e-06 0.0 0.7763400818577846 0.0 0.0 0.0219439768073448 0.0 0.0 0.0 0.0 3 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1257906 C3 LRP1 C3-LRP1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.3492263128574693e-06 0.6319926036888139 0.0 0.0 0.0265972645862203 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1258054 VEGFC FLT1 VEGFC-FLT1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.3470695348798324e-06 0.7745997874735252 0.0 0.0 0.0215813276111062 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1258074 EFNB2 PECAM1 EFNB2-PECAM1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.3463743645745885e-06 0.7800321422220979 0.0 0.0 0.0213929720256037 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1258134 VEGFC FLT1 VEGFC-FLT1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.3451931936091e-06 0.0 0.4630488285702799 0.0 0.0 0.0359289752254096 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1258142 A2M LRP1 A2M-LRP1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.3450033760813075e-06 0.4648000335061383 0.0 0.0 0.0357762282281787 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1258401 CD48 CD2 CD48-CD2 Macrophages Unassigned Macrophages -> Unassigned 2.340313437566889e-06 0.7719609236370527 0.0 0.0 0.0212837736082081 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1258599 VWF ITGA9 VWF-ITGA9 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.33634167937193e-06 0.0 0.2531744428854943 0.0 0.0 0.0642389143033604 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1258724 CD48 CD2 CD48-CD2 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.333105606915016e-06 0.4593282471594782 0.0 0.0 0.0351142257737683 0.0 0.0 0.0 0.0 0.0 29 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1258870 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 2.331045846019413e-06 0.0 0.6571792026963191 0.0 0.0 0.0244129856070659 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1259139 CXCL12 CXCR4 CXCL12-CXCR4 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.323992696554993e-06 0.6160088550075702 0.0 0.0 0.0255753403203798 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1259142 CXCL12 ITGA4 CXCL12-ITGA4 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.323992696554993e-06 0.6160088550075702 0.0 0.0 0.0255753403203798 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1259302 EFNB2 PECAM1 EFNB2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 2.321376440801664e-06 0.662063103571249 0.0 0.0 0.0236359933700329 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1259334 CLEC2D KLRB1 CLEC2D-KLRB1 B Cells Unassigned B Cells -> Unassigned 2.32100553180204e-06 0.7797302331085993 0.0 0.0 0.0200499113739789 0.0 0.0 0.0 0.0 0.0 2 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1259580 C1QB LRP1 C1QB-LRP1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.3161788818134543e-06 0.8498991475190484 0.0 0.0 0.018166235813628 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1259740 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 2.312170164899772e-06 0.6249837837987587 0.0 0.0 0.0244483651952677 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1260141 CLEC2D KLRB1 CLEC2D-KLRB1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.3054388779262867e-06 0.6605327397359113 0.0 0.0 0.0227314494836465 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1260145 CD48 CD2 CD48-CD2 Unassigned 11q13 Invasive Tumor Cells Unassigned -> 11q13 Invasive Tumor Cells 2.30528196429855e-06 0.0 0.6614977577544194 0.0 0.0 0.0226890201466244 0.0 0.0 0.0 0.0 13 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1260514 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 2.298290050555952e-06 0.0 0.663300745568453 0.0 0.0 0.0222186841038061 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1260756 COL4A1 CD93 COL4A1-CD93 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.2947762997586143e-06 0.8684504425765611 0.0 0.0 0.0168149984327668 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1261023 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.289677990660925e-06 0.0 0.4614667734221426 0.0 0.0 0.0312252462757311 0.0 0.0 0.0 0.0 6 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1261097 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.286932835411114e-06 0.0 0.4600037439857229 0.0 0.0 0.0310998965832685 0.0 0.0 0.0 0.0 36 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1261170 EFNB2 PECAM1 EFNB2-PECAM1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.285768398433825e-06 0.4619393085577573 0.0 0.0 0.0308750930304183 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1261255 VEGFC FLT1 VEGFC-FLT1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.282929996129595e-06 0.0 0.777821334064334 0.0 0.0 0.0182001711419816 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1261682 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 2.275162807758241e-06 0.0 0.7754239189773715 0.0 0.0 0.0178869147172998 0.0 0.0 0.0 0.0 9 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1262323 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Plasma Cells Unassigned -> Plasma Cells 2.264053414225611e-06 0.0 0.4600037439857229 0.0 0.0 0.0292791515533623 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1262350 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.2631971247426856e-06 0.0 0.4596166826058663 0.0 0.0 0.0292373734098458 0.0 0.0 0.0 0.0 6 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1262500 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.2614243838754853e-06 0.7160288858520609 0.0 0.0 0.0186793449598515 0.0 0.0 0.0 0.0 0.0 29 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1262501 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.2614243838754853e-06 0.7160288858520609 0.0 0.0 0.0186793449598515 0.0 0.0 0.0 0.0 0.0 29 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1262613 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 2.2590449035287576e-06 0.6593525851613742 0.0 0.0 0.0201572483258557 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1262971 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.255462841254148e-06 0.6301823358791634 0.0 0.0 0.0208904415011529 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1262972 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.255462841254148e-06 0.6301823358791634 0.0 0.0 0.0208904415011529 0.0 0.0 0.0 0.0 0.0 5 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1263076 C1QB LRP1 C1QB-LRP1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 2.253759390853364e-06 0.0 0.9078204025796472 0.0 0.0 0.0144359394371152 0.0 0.0 0.0 0.0 9 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1263085 HSPG2 LRP1 HSPG2-LRP1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 2.253759390853364e-06 0.0 0.9078204025796472 0.0 0.0 0.0144359394371152 0.0 0.0 0.0 0.0 9 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1263092 A2M LRP1 A2M-LRP1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 2.253759390853364e-06 0.0 0.9078204025796472 0.0 0.0 0.0144359394371152 0.0 0.0 0.0 0.0 9 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1263096 C3 LRP1 C3-LRP1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 2.253759390853364e-06 0.0 0.9078204025796472 0.0 0.0 0.0144359394371152 0.0 0.0 0.0 0.0 9 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1263104 VWF LRP1 VWF-LRP1 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 2.253759390853364e-06 0.0 0.9078204025796472 0.0 0.0 0.0144359394371152 0.0 0.0 0.0 0.0 9 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1263246 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 2.2517594358706204e-06 0.6582846571368821 0.0 0.0 0.0198024073017111 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1263253 VEGFC FLT1 VEGFC-FLT1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.2516267422272907e-06 0.7745997874735252 0.0 0.0 0.016822895653248 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1263751 CD48 CD2 CD48-CD2 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 2.242354585353782e-06 0.7719609236370527 0.0 0.0 0.0164675938709007 0.0 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1263841 C1QB LRP1 C1QB-LRP1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.2407098420251373e-06 0.0 0.6207977546603366 0.0 0.0 0.0203874717835032 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1263864 HSPG2 LRP1 HSPG2-LRP1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.2407098420251373e-06 0.0 0.6207977546603366 0.0 0.0 0.0203874717835032 0.0 0.0 0.0 0.0 3 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1263868 VWF LRP1 VWF-LRP1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.2407098420251373e-06 0.0 0.6207977546603366 0.0 0.0 0.0203874717835032 0.0 0.0 0.0 0.0 3 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1263869 C3 LRP1 C3-LRP1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.2407098420251373e-06 0.0 0.6207977546603366 0.0 0.0 0.0203874717835032 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1263870 A2M LRP1 A2M-LRP1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 2.2407098420251373e-06 0.0 0.6207977546603366 0.0 0.0 0.0203874717835032 0.0 0.0 0.0 0.0 3 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1264093 C1QB LRP1 C1QB-LRP1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 2.2367619630436625e-06 0.7753420160918723 0.0 0.0 0.0161519521398178 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1264739 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Macrophages Unassigned -> Macrophages 2.224279640134197e-06 0.0 0.9130058539314824 0.0 0.0 0.0132636308162813 0.0 0.0 0.0 0.0 4 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1264995 VEGFC FLT1 VEGFC-FLT1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.219531208602573e-06 0.6593525851613742 0.0 0.0 0.018132161410931 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1265203 CLEC2D KLRB1 CLEC2D-KLRB1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 2.2159034193036398e-06 0.6605327397359113 0.0 0.0 0.0179229861158654 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1265645 A2M LRP1 A2M-LRP1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.2064136875402155e-06 0.7741139100414175 0.0 0.0 0.0149044683666724 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1265801 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Mast Cells Unassigned -> Mast Cells 2.2033857806644834e-06 0.0 0.7754239189773715 0.0 0.0 0.0147571931436988 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1266163 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Pericytes Unassigned -> Pericytes 2.197675152163233e-06 0.0 0.885766439573873 0.0 0.0 0.0127192475389894 0.0 0.0 0.0 0.0 7 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1266281 MMP2 PECAM1 MMP2-PECAM1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.1956695344797864e-06 0.0 0.6331674633943454 0.0 0.0 0.0176963220730796 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1266283 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.1956695344797864e-06 0.0 0.6331674633943454 0.0 0.0 0.0176963220730796 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1266831 COL4A1 CD93 COL4A1-CD93 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.18764543565925e-06 0.8684504425765611 0.0 0.0 0.0126216524880575 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1266944 MMRN2 CD93 MMRN2-CD93 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.1856880722476005e-06 0.7205550478301406 0.0 0.0 0.0151307911035231 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1266945 MMRN2 CLEC14A MMRN2-CLEC14A Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.1856880722476005e-06 0.7205550478301406 0.0 0.0 0.0151307911035231 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1266966 MMRN2 CD93 MMRN2-CD93 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.1851786590125484e-06 0.6301823358791634 0.0 0.0 0.0172764782878141 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1266968 MMRN2 CLEC14A MMRN2-CLEC14A Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.1851786590125484e-06 0.6301823358791634 0.0 0.0 0.0172764782878141 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1267243 VEGFC FLT1 VEGFC-FLT1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.1805712818642885e-06 0.0 0.4630488285702799 0.0 0.0 0.0232163927704059 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1267749 C3 LRP1 C3-LRP1 Macrophages Unassigned Macrophages -> Unassigned 2.172903673349508e-06 0.9487258305485792 0.0 0.0 0.0110943464444434 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1268279 VWF SELP VWF-SELP Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.1642210074301407e-06 0.0 0.4623922682986163 0.0 0.0 0.0222228052993653 0.0 0.0 0.0 0.0 36 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1268281 CD34 SELP CD34-SELP Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.1642210074301407e-06 0.0 0.4623922682986163 0.0 0.0 0.0222228052993653 0.0 0.0 0.0 0.0 36 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1268511 MMP2 PECAM1 MMP2-PECAM1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.1601802946884213e-06 0.6303642896310324 0.0 0.0 0.0161193721503025 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1268559 DLL1 NOTCH3 DLL1-NOTCH3 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.1583514675547606e-06 0.6249837837987587 0.0 0.0 0.0161757332769496 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1269018 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 2.1505129519972014e-06 0.0 0.4600037439857229 0.0 0.0 0.0215025911544899 0.0 0.0 0.0 0.0 6 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1269108 CD34 SELP CD34-SELP T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.1483424292323664e-06 0.633566764858408 0.0 0.0 0.015517736049123 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1269142 CXCL12 ITGA4 CXCL12-ITGA4 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 2.1477622732763227e-06 0.7487535481622718 0.0 0.0 0.0131092554497256 0.0 0.0 0.0 0.0 0.0 9 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1269147 CXCL12 CXCR4 CXCL12-CXCR4 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 2.1477622732763227e-06 0.7487535481622718 0.0 0.0 0.0131092554497256 0.0 0.0 0.0 0.0 0.0 9 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1269350 MMP2 PECAM1 MMP2-PECAM1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 2.143354450094327e-06 0.9067635403815892 0.0 0.0 0.0106922602624424 0.0 0.0 0.0 0.0 0.0 9 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1269496 CLEC2D KLRB1 CLEC2D-KLRB1 Pericytes Unassigned Pericytes -> Unassigned 2.141918233078257e-06 0.8721681415062816 0.0 0.0 0.0110717612136884 0.0 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1270147 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 2.1310747213041724e-06 0.6561647292424944 0.0 0.0 0.0142750905665976 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1270206 HSPG2 LRP1 HSPG2-LRP1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.129305246523651e-06 0.4629984640915818 0.0 0.0 0.0201301851612071 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1270439 CD48 CD2 CD48-CD2 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.124977927487424e-06 0.8667347161816407 0.0 0.0 0.0106228227237899 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1270476 CXCL12 ITGA4 CXCL12-ITGA4 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.124483812686334e-06 0.6160088550075702 0.0 0.0 0.0149256517769723 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1270482 CXCL12 CXCR4 CXCL12-CXCR4 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.124483812686334e-06 0.6160088550075702 0.0 0.0 0.0149256517769723 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1270521 COL4A2 CD93 COL4A2-CD93 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.1240482497326893e-06 0.0 0.7779918296243433 0.0 0.0 0.0118035014556376 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1270523 MMRN2 CD93 MMRN2-CD93 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.1240482497326893e-06 0.0 0.7779918296243433 0.0 0.0 0.0118035014556376 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1270525 COL4A1 CD93 COL4A1-CD93 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.1240482497326893e-06 0.0 0.7779918296243433 0.0 0.0 0.0118035014556376 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1270615 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 2.122714160611851e-06 0.6659645551150886 0.0 0.0 0.0137371823984124 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1270858 CCN1 CAV1 CCN1-CAV1 Unassigned Plasma Cells Unassigned -> Plasma Cells 2.1184001385805324e-06 0.0 0.7283139964676212 0.0 0.0 0.0124087765732037 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1270928 MMP2 PECAM1 MMP2-PECAM1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.117090403977442e-06 0.0 0.7167436199046466 0.0 0.0 0.0125623889131764 0.0 0.0 0.0 0.0 36 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1270929 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.117090403977442e-06 0.0 0.7167436199046466 0.0 0.0 0.0125623889131764 0.0 0.0 0.0 0.0 36 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1271036 C1QB LRP1 C1QB-LRP1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.1162023010951717e-06 0.6626993710110988 0.0 0.0 0.0135527119637784 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1271122 MMP2 PECAM1 MMP2-PECAM1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.114824023182454e-06 0.6303642896310324 0.0 0.0 0.0141923232885854 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1271268 EFNB2 PECAM1 EFNB2-PECAM1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 2.112037266717087e-06 0.7800321422220979 0.0 0.0 0.0113788029360913 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1271697 CD48 CD2 CD48-CD2 Mast Cells Unassigned Mast Cells -> Unassigned 2.1042846888604083e-06 0.7719609236370527 0.0 0.0 0.0112468593062777 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1271712 C1QB LRP1 C1QB-LRP1 Pericytes Unassigned Pericytes -> Unassigned 2.103752266366365e-06 0.7753420160918723 0.0 0.0 0.0111808254589153 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1271786 CCN1 CAV1 CCN1-CAV1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 2.102561699289519e-06 0.6213271600240247 0.0 0.0 0.013905026986541 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1272087 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.09650138067807e-06 0.7205550478301406 0.0 0.0 0.0117842887908422 0.0 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1272089 MMRN2 CD93 MMRN2-CD93 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.09650138067807e-06 0.7205550478301406 0.0 0.0 0.0117842887908422 0.0 0.0 0.0 0.0 0.0 29 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1272104 VEGFC FLT1 VEGFC-FLT1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.095623712540232e-06 0.0 0.777821334064334 0.0 0.0 0.0108892901157311 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1272479 CD48 CD2 CD48-CD2 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.089565934395905e-06 0.4593282471594782 0.0 0.0 0.0181222899145132 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1272486 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.0892018043373563e-06 0.6332974881236617 0.0 0.0 0.0131302879503246 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1272489 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.0892018043373563e-06 0.6332974881236617 0.0 0.0 0.0131302879503246 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1272493 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.0892018043373563e-06 0.6332974881236617 0.0 0.0 0.0131302879503246 0.0 0.0 0.0 0.0 0.0 5 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1272511 COL4A2 CD93 COL4A2-CD93 Macrophages Unassigned Macrophages -> Unassigned 2.0880385453792257e-06 0.9188764516910942 0.0 0.0 0.0090193130488293 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1272659 MMP2 PECAM1 MMP2-PECAM1 Macrophages Unassigned Macrophages -> Unassigned 2.085239666833283e-06 0.9330801352629944 0.0 0.0 0.0088108219576754 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1272720 C3 LRP1 C3-LRP1 Pericytes Unassigned Pericytes -> Unassigned 2.083881421848883e-06 0.8911088195487638 0.0 0.0 0.0091898156146168 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1272773 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.082626203367085e-06 0.0 0.4600037439857229 0.0 0.0 0.017738069381683 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1272780 C1QB LRP1 C1QB-LRP1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 2.082323449969768e-06 0.4601010570874773 0.0 0.0 0.0177188549930425 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1272843 CCN1 CAV1 CCN1-CAV1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.081624968431116e-06 0.0 0.252518874138558 0.0 0.0 0.0322196586137726 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1272978 THBS2 CD36 THBS2-CD36 Pericytes Unassigned Pericytes -> Unassigned 2.077663139288975e-06 0.9197297916541942 0.0 0.0 0.0087456089304998 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1273206 VEGFC FLT1 VEGFC-FLT1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 2.073826081013716e-06 0.6593525851613742 0.0 0.0 0.0120646829101097 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1273229 CCN1 CAV1 CCN1-CAV1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 2.073217163691489e-06 0.9219165193585238 0.0 0.0 0.0086134406931133 0.0 0.0 0.0 0.0 0.0 9 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1273267 CCN1 CAV1 CCN1-CAV1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.07216227784345e-06 0.0 0.62431395375366 0.0 0.0 0.0126805820762719 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1273423 C1QB LRP1 C1QB-LRP1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.0683717774442184e-06 0.4601010570874773 0.0 0.0 0.0170183763647696 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1273511 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 2.0661943949942617e-06 0.0 0.7467524951532132 0.0 0.0 0.0104195741475089 0.0 0.0 0.0 0.0 6 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1273655 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.064030375306407e-06 0.0 0.7754072541855492 0.0 0.0 0.009971631136135 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1274167 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.054279361946684e-06 0.6319926036888139 0.0 0.0 0.011891719340537 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1274295 CD48 CD2 CD48-CD2 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.0506414734186065e-06 0.4593282471594782 0.0 0.0 0.0161888123016941 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1274807 COL4A1 CD93 COL4A1-CD93 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.040372184931761e-06 0.0 0.4630027772793905 0.0 0.0 0.0155837683010033 0.0 0.0 0.0 0.0 36 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1274812 COL4A2 CD93 COL4A2-CD93 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.040372184931761e-06 0.0 0.4630027772793905 0.0 0.0 0.0155837683010033 0.0 0.0 0.0 0.0 36 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1274815 MMRN2 CD93 MMRN2-CD93 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 2.040372184931761e-06 0.0 0.4630027772793905 0.0 0.0 0.0155837683010033 0.0 0.0 0.0 0.0 36 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1275029 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Pericytes Unassigned -> Pericytes 2.0350892422109056e-06 0.0 0.7757991160529997 0.0 0.0 0.0091569531245039 0.0 0.0 0.0 0.0 7 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1275156 VWF ITGA9 VWF-ITGA9 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 2.0330259296943555e-06 0.0 0.6252253442669611 0.0 0.0 0.0112932915661816 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1275204 DLL1 NOTCH3 DLL1-NOTCH3 Macrophages Unassigned Macrophages -> Unassigned 2.0318912595680878e-06 0.8771078809726828 0.0 0.0 0.0080232294691882 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1275216 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.0315389587339054e-06 0.0 0.8445107771175474 0.0 0.0 0.0083242517891534 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1275333 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.0304140565326417e-06 0.0 0.7746834992804791 0.0 0.0 0.0090444648829713 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1275334 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 2.0304140565326417e-06 0.0 0.7746834992804791 0.0 0.0 0.0090444648829713 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1275726 CXCL12 ITGA4 CXCL12-ITGA4 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.022769046727113e-06 0.8023917560710954 0.0 0.0 0.0085367158000785 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1275736 CXCL12 CXCR4 CXCL12-CXCR4 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.022769046727113e-06 0.8023917560710954 0.0 0.0 0.0085367158000785 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1275850 HSPG2 LRP1 HSPG2-LRP1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.0211520455267887e-06 0.0 0.2550748532138862 0.0 0.0 0.0267255153180908 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1275862 A2M LRP1 A2M-LRP1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.0211520455267887e-06 0.0 0.2550748532138862 0.0 0.0 0.0267255153180908 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1275863 C1QB LRP1 C1QB-LRP1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.0211520455267887e-06 0.0 0.2550748532138862 0.0 0.0 0.0267255153180908 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1275866 C3 LRP1 C3-LRP1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.0211520455267887e-06 0.0 0.2550748532138862 0.0 0.0 0.0267255153180908 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1275875 VWF LRP1 VWF-LRP1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 2.0211520455267887e-06 0.0 0.2550748532138862 0.0 0.0 0.0267255153180908 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1276102 VEGFC FLT1 VEGFC-FLT1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 2.017065577568306e-06 0.4636527906642655 0.0 0.0 0.014525360548861 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1276217 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Plasma Cells Unassigned -> Plasma Cells 2.0160376359052966e-06 0.0 0.4642836810638544 0.0 0.0 0.0144613249009303 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1276357 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 2.013458439505482e-06 0.7941469661104034 0.0 0.0 0.0083898580598364 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1276633 MMP2 PECAM1 MMP2-PECAM1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 2.0084500022417792e-06 0.6303642896310324 0.0 0.0 0.0104129581710415 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1276682 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.007770255775668e-06 0.6160088550075702 0.0 0.0 0.0106340017102282 0.0 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1276691 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 2.007770255775668e-06 0.6160088550075702 0.0 0.0 0.0106340017102282 0.0 0.0 0.0 0.0 0.0 5 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1276711 CLEC2D KLRB1 CLEC2D-KLRB1 Plasma Cells Unassigned Plasma Cells -> Unassigned 2.0074515563865688e-06 0.4625081978296446 0.0 0.0 0.0141498126994191 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1276832 C1QB LRP1 C1QB-LRP1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.005207277550114e-06 0.0 0.6207977546603366 0.0 0.0 0.0104714078116759 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1276842 VWF LRP1 VWF-LRP1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.005207277550114e-06 0.0 0.6207977546603366 0.0 0.0 0.0104714078116759 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1276844 HSPG2 LRP1 HSPG2-LRP1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.005207277550114e-06 0.0 0.6207977546603366 0.0 0.0 0.0104714078116759 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1276850 A2M LRP1 A2M-LRP1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.005207277550114e-06 0.0 0.6207977546603366 0.0 0.0 0.0104714078116759 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1276874 C3 LRP1 C3-LRP1 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 2.005207277550114e-06 0.0 0.6207977546603366 0.0 0.0 0.0104714078116759 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1277065 JAG1 NOTCH2 JAG1-NOTCH2 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 2.0002715292745984e-06 0.6303682835571691 0.0 0.0 0.0101610580570933 0.0 0.0 0.0 0.0 0.0 29 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1277705 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 1.987226161839496e-06 0.6303642896310324 0.0 0.0 0.0097699360831605 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1278334 CD34 SELP CD34-SELP Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 1.975799367043424e-06 0.7168245244832976 0.0 0.0 0.0082993421103349 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1278467 CCN1 CAV1 CCN1-CAV1 Unassigned Dendritic Cells Unassigned -> Dendritic Cells 1.9734283618360574e-06 0.0 0.62431395375366 0.0 0.0 0.009460730808256 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1278478 CD48 CD2 CD48-CD2 Pericytes Unassigned Pericytes -> Unassigned 1.9726515902177947e-06 0.7719609236370527 0.0 0.0 0.0076331962782219 0.0 0.0 0.0 0.0 0.0 5 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1278482 HSPG2 LRP1 HSPG2-LRP1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.972598384270559e-06 0.7789175740361626 0.0 0.0 0.0075637985935472 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1278650 COL4A1 CD93 COL4A1-CD93 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.9697742741850587e-06 0.4604235282221027 0.0 0.0 0.0126864732057784 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1278682 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.9691443808049256e-06 0.6213271600240247 0.0 0.0 0.0093830613230477 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1278717 DLL1 NOTCH3 DLL1-NOTCH3 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.968582632625542e-06 0.9470274865242416 0.0 0.0 0.0061455194924501 0.0 0.0 0.0 0.0 0.0 9 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1278815 C3 LRP1 C3-LRP1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.968171124177543e-06 0.0 0.9078204025796472 0.0 0.0 0.0064028969591119 0.0 0.0 0.0 0.0 10 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1278818 C1QB LRP1 C1QB-LRP1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.968171124177543e-06 0.0 0.9078204025796472 0.0 0.0 0.0064028969591119 0.0 0.0 0.0 0.0 10 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1278831 A2M LRP1 A2M-LRP1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.968171124177543e-06 0.0 0.9078204025796472 0.0 0.0 0.0064028969591119 0.0 0.0 0.0 0.0 10 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1278835 HSPG2 LRP1 HSPG2-LRP1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.968171124177543e-06 0.0 0.9078204025796472 0.0 0.0 0.0064028969591119 0.0 0.0 0.0 0.0 10 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1278839 VWF LRP1 VWF-LRP1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.968171124177543e-06 0.0 0.9078204025796472 0.0 0.0 0.0064028969591119 0.0 0.0 0.0 0.0 10 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1278895 VEGFC FLT1 VEGFC-FLT1 Unassigned Macrophages Unassigned -> Macrophages 1.966979018043824e-06 0.0 0.8998347793593909 0.0 0.0 0.0064362797035136 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1278929 C3 LRP1 C3-LRP1 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 1.9665884511365867e-06 0.8911088195487638 0.0 0.0 0.0064915662046245 0.0 0.0 0.0 0.0 0.0 5 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1279269 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Macrophages Unassigned -> Macrophages 1.961514830993966e-06 0.0 0.773263018678637 0.0 0.0 0.0073658308476012 0.0 0.0 0.0 0.0 4 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1279721 COL4A2 CD93 COL4A2-CD93 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.953119198477714e-06 0.6582846571368821 0.0 0.0 0.0084325366891025 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1279841 HSPG2 LRP1 HSPG2-LRP1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.949753822907732e-06 0.7789175740361626 0.0 0.0 0.0070532058552773 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1279864 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Pericytes Unassigned -> Pericytes 1.9493354065181724e-06 0.0 0.773263018678637 0.0 0.0 0.0070956399217802 0.0 0.0 0.0 0.0 7 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1279929 COL4A2 CD93 COL4A2-CD93 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.9474091040197966e-06 0.8840293712888387 0.0 0.0 0.0061698665784747 0.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1280036 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.945776652421245e-06 0.6342079770588467 0.0 0.0 0.0085570823799139 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1280039 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.945776652421245e-06 0.6342079770588467 0.0 0.0 0.0085570823799139 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1280071 CD48 CD2 CD48-CD2 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 1.945713507122216e-06 0.6659645551150886 0.0 0.0 0.0081474500750471 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1280387 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.938755466868772e-06 0.0 0.6632137581773894 0.0 0.0 0.0080072638027924 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1280406 DLL1 NOTCH3 DLL1-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.9381522017100542e-06 0.6249837837987587 0.0 0.0 0.0084812136822336 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1280417 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.9377747173381e-06 0.633566764858408 0.0 0.0 0.0083565457974945 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1280709 VWF ITGA9 VWF-ITGA9 Unassigned B Cells Unassigned -> B Cells 1.9330248550896623e-06 0.0 0.6252253442669611 0.0 0.0 0.0083442542366581 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1280840 CCN1 CAV1 CCN1-CAV1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.9313042769367e-06 0.6213271600240247 0.0 0.0 0.0083518627398662 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1280913 CD48 CD2 CD48-CD2 Unassigned CAFs, DCIS Associated Unassigned -> CAFs, DCIS Associated 1.929843388450081e-06 0.0 0.4603649459881741 0.0 0.0 0.0112209532878862 0.0 0.0 0.0 0.0 36 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1281008 VEGFC FLT1 VEGFC-FLT1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.928931064881394e-06 0.0 0.7472387841445823 0.0 0.0 0.0068935067166085 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1281031 THBS2 CD36 THBS2-CD36 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.928105040877916e-06 0.9197297916541942 0.0 0.0 0.0055862851962672 0.0 0.0 0.0 0.0 0.0 9 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1281102 CCN1 CAV1 CCN1-CAV1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.9269908027914797e-06 0.0 0.62431395375366 0.0 0.0 0.0082011408892332 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1281110 VWF LRP1 VWF-LRP1 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 1.926847200005784e-06 0.7158082793127664 0.0 0.0 0.0071496754272206 0.0 0.0 0.0 0.0 0.0 29 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1281111 VWF ITGA9 VWF-ITGA9 CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 1.926847200005784e-06 0.7158082793127664 0.0 0.0 0.0071496754272206 0.0 0.0 0.0 0.0 0.0 29 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1281112 VWF SELP VWF-SELP CAFs, DCIS Associated Unassigned CAFs, DCIS Associated -> Unassigned 1.926847200005784e-06 0.7158082793127664 0.0 0.0 0.0071496754272206 0.0 0.0 0.0 0.0 0.0 29 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1281295 DLL1 NOTCH3 DLL1-NOTCH3 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.9246277789892065e-06 0.7835752212271604 0.0 0.0 0.0064863313435223 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1281385 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned T Lymphocytes Unassigned -> T Lymphocytes 1.9233456822873286e-06 0.0 0.6347970925105053 0.0 0.0 0.0079745943515326 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1281483 VEGFC FLT1 VEGFC-FLT1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.922112043521028e-06 0.7745997874735252 0.0 0.0 0.0065101973396288 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1281622 CD34 SELP CD34-SELP Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.919685667326572e-06 0.633566764858408 0.0 0.0 0.0078992851324392 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1281686 CXCL12 ITGA4 CXCL12-ITGA4 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.918367488036674e-06 0.8730912658940219 0.0 0.0 0.0057086106530109 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1281689 CXCL12 CXCR4 CXCL12-CXCR4 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.918367488036674e-06 0.8730912658940219 0.0 0.0 0.0057086106530109 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1281826 DLL4 NOTCH4 DLL4-NOTCH4 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 1.9157836480117406e-06 0.7160288858520609 0.0 0.0 0.0069047442087267 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1281829 DLL4 NOTCH3 DLL4-NOTCH3 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 1.9157836480117406e-06 0.7160288858520609 0.0 0.0 0.0069047442087267 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1282061 EFNB2 PECAM1 EFNB2-PECAM1 Macrophages Unassigned Macrophages -> Unassigned 1.912818975805114e-06 0.8913986641324685 0.0 0.0 0.0054950348959687 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1282237 CD48 CD2 CD48-CD2 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.910072664264277e-06 0.0 0.4603649459881741 0.0 0.0 0.0105486447632276 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1282286 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.9089712361784128e-06 0.0 0.6347970925105053 0.0 0.0 0.0076236123034427 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1282386 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.9063149544138428e-06 0.6589792304505506 0.0 0.0 0.0072827533047186 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1282485 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Macrophages Unassigned -> Macrophages 1.9040873554900855e-06 0.0 0.8818120773736414 0.0 0.0 0.0054043611446182 0.0 0.0 0.0 0.0 4 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1282594 CD48 CD2 CD48-CD2 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.900774553534456e-06 0.7453966474499909 0.0 0.0 0.006326966401379 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1282665 DLL4 NOTCH3 DLL4-NOTCH3 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.8989281202787336e-06 0.6342079770588467 0.0 0.0 0.0073929685753755 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1282666 DLL4 NOTCH4 DLL4-NOTCH4 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.8989281202787336e-06 0.6342079770588467 0.0 0.0 0.0073929685753755 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1282672 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.89858370494612e-06 0.0 0.7480927101953669 0.0 0.0 0.006260692484444 0.0 0.0 0.0 0.0 6 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1282736 CCN1 CAV1 CCN1-CAV1 Macrophages Unassigned Macrophages -> Unassigned 1.8971701026165e-06 0.8619922139338987 0.0 0.0 0.0054092055025683 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1282852 A2M LRP1 A2M-LRP1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.8946217651982336e-06 0.6561647292424944 0.0 0.0 0.0070489045197697 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1283070 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.8912438213636785e-06 0.0 0.6571792026963191 0.0 0.0 0.0069630688870869 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1283107 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.89073402808833e-06 0.0 0.657421674383923 0.0 0.0 0.0069492509109592 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1283284 CCN1 CAV1 CCN1-CAV1 Unassigned Macrophages Unassigned -> Macrophages 1.886988571081248e-06 0.0 0.8818704453527788 0.0 0.0 0.0051192928876727 0.0 0.0 0.0 0.0 4 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1283545 CD34 SELP CD34-SELP Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.8841928443187395e-06 0.0 0.4623922682986163 0.0 0.0 0.0096770075292062 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1283548 VWF SELP VWF-SELP Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.8841928443187395e-06 0.0 0.4623922682986163 0.0 0.0 0.0096770075292062 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1283777 VEGFC FLT1 VEGFC-FLT1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.8793811114821624e-06 0.0 0.6593689120110077 0.0 0.0 0.0066828239855783 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1283964 VWF ITGA9 VWF-ITGA9 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.8751617410983368e-06 0.0 0.7831795333113832 0.0 0.0 0.0055509879377996 0.0 0.0 0.0 0.0 6 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1284052 C3 LRP1 C3-LRP1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.873487216089796e-06 0.8911088195487638 0.0 0.0 0.0048525806497539 0.0 0.0 0.0 0.0 0.0 9 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1284144 COL4A2 CD93 COL4A2-CD93 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.8710481145334247e-06 0.7482742921073442 0.0 0.0 0.005733874009046 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1284290 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.8688147289505023e-06 0.0 0.6632137581773894 0.0 0.0 0.0064230792457803 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1284530 COL4A1 CD93 COL4A1-CD93 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.8633145845905736e-06 0.0 0.7779918296243433 0.0 0.0 0.0053794918117879 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1284536 COL4A2 CD93 COL4A2-CD93 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.8633145845905736e-06 0.0 0.7779918296243433 0.0 0.0 0.0053794918117879 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1284539 MMRN2 CD93 MMRN2-CD93 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.8633145845905736e-06 0.0 0.7779918296243433 0.0 0.0 0.0053794918117879 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1284564 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.8631581307609945e-06 0.0 0.7154802332407408 0.0 0.0 0.0058465532256424 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1284602 THBS2 CD36 THBS2-CD36 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.8620119243371509e-06 0.0 0.7373999388878224 0.0 0.0 0.0056518532344078 0.0 0.0 0.0 0.0 6 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1284980 CLEC2D KLRB1 CLEC2D-KLRB1 Mast Cells Unassigned Mast Cells -> Unassigned 1.8547699297410891e-06 0.831981591331937 0.0 0.0 0.0048935684578858 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1285415 THBS2 CD36 THBS2-CD36 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.8459836068077696e-06 0.6242573126045354 0.0 0.0 0.0063387366560491 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1285423 CD48 CD2 CD48-CD2 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 1.8459753730352812e-06 0.0 0.7763428264267787 0.0 0.0 0.0050968401714881 0.0 0.0 0.0 0.0 9 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1285571 VWF ITGA9 VWF-ITGA9 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.8429283790533664e-06 0.0 0.7292496872084557 0.0 0.0 0.0053724660607752 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1285664 COL4A1 CD93 COL4A1-CD93 Macrophages Unassigned Macrophages -> Unassigned 1.8416258818365569e-06 0.9102252263107924 0.0 0.0 0.0042860632265532 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1285671 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.841547947019008e-06 0.0 0.657421674383923 0.0 0.0 0.0059327142047454 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1285688 THBS2 CD36 THBS2-CD36 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 1.8408769868422095e-06 0.0 0.6176321640000088 0.0 0.0 0.0063011237754475 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1286097 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.8304613816719596e-06 0.0 0.8818326005152037 0.0 0.0 0.0042655619249233 0.0 0.0 0.0 0.0 10 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1286105 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.8304613816719596e-06 0.0 0.8818326005152037 0.0 0.0 0.0042655619249233 0.0 0.0 0.0 0.0 10 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1286152 DLL1 NOTCH3 DLL1-NOTCH3 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.8302956433527128e-06 0.7296454584598743 0.0 0.0 0.0051524613572059 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1286364 COL4A1 CD93 COL4A1-CD93 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.82577701353076e-06 0.7766289238087107 0.0 0.0 0.0047694898966413 0.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1286458 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.8229025467707628e-06 0.0 0.6347970925105053 0.0 0.0 0.0057802287131517 0.0 0.0 0.0 0.0 3 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1286671 THBS2 CD36 THBS2-CD36 Endothelial Cells Unassigned Endothelial Cells -> Unassigned 1.8196726966496003e-06 0.9197297916541942 0.0 0.0 0.0039472834455595 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1286774 C3 LRP1 C3-LRP1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 1.817572350455268e-06 0.7148920381722296 0.0 0.0 0.005043231651446 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1286873 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 1.8157693900567796e-06 0.0 0.7746834992804791 0.0 0.0 0.0046263543438723 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1286876 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned T Lymphocytes Unassigned -> T Lymphocytes 1.8157693900567796e-06 0.0 0.7746834992804791 0.0 0.0 0.0046263543438723 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1287438 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.805107692279837e-06 0.0 0.4596166826058663 0.0 0.0 0.0075270071967493 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1287468 CD34 SELP CD34-SELP Macrophages Unassigned Macrophages -> Unassigned 1.804295701016212e-06 0.8963354148873306 0.0 0.0 0.0038492365148421 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1287482 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Mast Cells Unassigned -> Mast Cells 1.8040079370767769e-06 0.0 0.7757991160529997 0.0 0.0 0.0044430418127202 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1287806 CD48 CD2 CD48-CD2 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.797530529530157e-06 0.0 0.8581827408615759 0.0 0.0 0.003930762149527 0.0 0.0 0.0 0.0 3 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1287855 DLL4 NOTCH4 DLL4-NOTCH4 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.796647996969134e-06 0.6342079770588467 0.0 0.0 0.0053032910137447 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1287858 DLL4 NOTCH3 DLL4-NOTCH3 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.796647996969134e-06 0.6342079770588467 0.0 0.0 0.0053032910137447 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1287996 A2M LRP1 A2M-LRP1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.7937437002489815e-06 0.8937519114898692 0.0 0.0 0.0037268694422441 0.0 0.0 0.0 0.0 0.0 9 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1288079 CD48 CD2 CD48-CD2 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.791939818217157e-06 0.0 0.4603649459881741 0.0 0.0 0.0071918009517169 0.0 0.0 0.0 0.0 6 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1288151 CCN1 CAV1 CCN1-CAV1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.7894646009848269e-06 0.0 0.943345641464811 0.0 0.0 0.0034806998160403 0.0 0.0 0.0 0.0 10 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1288185 C1QB LRP1 C1QB-LRP1 B Cells Unassigned B Cells -> Unassigned 1.788715713024687e-06 0.8703788833238396 0.0 0.0 0.0037630364713574 0.0 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1288225 CCN1 CAV1 CCN1-CAV1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.787847996246742e-06 0.6213271600240247 0.0 0.0 0.0052560850129547 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1288292 CXCL12 CXCR4 CXCL12-CXCR4 B Cells Unassigned B Cells -> Unassigned 1.7863124794648502e-06 0.6160088550075702 0.0 0.0 0.0052742025956585 0.0 0.0 0.0 0.0 0.0 2 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1288297 CXCL12 ITGA4 CXCL12-ITGA4 B Cells Unassigned B Cells -> Unassigned 1.7863124794648502e-06 0.6160088550075702 0.0 0.0 0.0052742025956585 0.0 0.0 0.0 0.0 0.0 2 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1288516 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.782133695143551e-06 0.6630837220165452 0.0 0.0 0.0048313935743179 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1288807 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned B Cells Unassigned -> B Cells 1.7737828539420618e-06 0.0 0.6331674633943454 0.0 0.0 0.0049190726392343 0.0 0.0 0.0 0.0 2 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1288808 MMP2 PECAM1 MMP2-PECAM1 Unassigned B Cells Unassigned -> B Cells 1.7737828539420618e-06 0.0 0.6331674633943454 0.0 0.0 0.0049190726392343 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1288828 THBS2 CD36 THBS2-CD36 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.7733411010625711e-06 0.6242573126045354 0.0 0.0 0.004981832968137 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1289169 EFNB2 PECAM1 EFNB2-PECAM1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.7661106899410954e-06 0.7451589345683471 0.0 0.0 0.0040724665904272 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1289201 CD34 SELP CD34-SELP Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.7657792285671615e-06 0.7871981482311898 0.0 0.0 0.0038506427265089 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1289295 VEGFC FLT1 VEGFC-FLT1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.7636638669831314e-06 0.0 0.6593689120110077 0.0 0.0 0.0045642085393754 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1289313 VWF SELP VWF-SELP Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.7629069528168776e-06 0.0 0.6572093097629401 0.0 0.0 0.0045674276780054 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1289318 CD34 SELP CD34-SELP Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.7629069528168776e-06 0.0 0.6572093097629401 0.0 0.0 0.0045674276780054 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1289490 VWF ITGA9 VWF-ITGA9 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.7583679052844933e-06 0.0 0.6252253442669611 0.0 0.0 0.0047273851759697 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1289660 DLL4 NOTCH4 DLL4-NOTCH4 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.75293967407825e-06 0.2490567623945399 0.0 0.0 0.011649387573427 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1289661 DLL4 NOTCH3 DLL4-NOTCH3 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.75293967407825e-06 0.2490567623945399 0.0 0.0 0.011649387573427 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1289746 CD48 CD2 CD48-CD2 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.7506155992669051e-06 0.0 0.4603649459881741 0.0 0.0 0.0062523288579129 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1289853 VWF SELP VWF-SELP Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.7475533967492774e-06 0.0 0.7760344326192508 0.0 0.0 0.0036702914086929 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1289854 CD34 SELP CD34-SELP Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.7475533967492774e-06 0.0 0.7760344326192508 0.0 0.0 0.0036702914086929 0.0 0.0 0.0 0.0 3 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1290010 MMRN2 CD93 MMRN2-CD93 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.744160565749405e-06 0.0 0.6587114738285964 0.0 0.0 0.0042738820064046 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1290014 COL4A2 CD93 COL4A2-CD93 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.744160565749405e-06 0.0 0.6587114738285964 0.0 0.0 0.0042738820064046 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1290016 COL4A1 CD93 COL4A1-CD93 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.744160565749405e-06 0.0 0.6587114738285964 0.0 0.0 0.0042738820064046 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1290019 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.744105875577309e-06 0.0 0.6347970925105053 0.0 0.0 0.0044340558155446 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1290516 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.7342337964402742e-06 0.0 0.2491545808994955 0.0 0.0 0.0109188419829382 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1290537 CD34 SELP CD34-SELP Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.7334957247139234e-06 0.633566764858408 0.0 0.0 0.0042829523358709 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1290566 THBS2 CD36 THBS2-CD36 Macrophages Unassigned Macrophages -> Unassigned 1.7328670480412618e-06 0.8858959974474152 0.0 0.0 0.0030563796158022 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1290577 COL4A2 CD93 COL4A2-CD93 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.7326559195866157e-06 0.0 0.4630027772793905 0.0 0.0 0.0058437228618857 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1290587 MMRN2 CD93 MMRN2-CD93 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.7326559195866157e-06 0.0 0.4630027772793905 0.0 0.0 0.0058437228618857 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1290588 COL4A1 CD93 COL4A1-CD93 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.7326559195866157e-06 0.0 0.4630027772793905 0.0 0.0 0.0058437228618857 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1290606 CD34 SELP CD34-SELP Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.7322500418974416e-06 0.2491449441646273 0.0 0.0 0.0108445362943651 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1290688 C3 LRP1 C3-LRP1 B Cells Unassigned B Cells -> Unassigned 1.729700240613664e-06 0.6319926036888139 0.0 0.0 0.0042375227960614 0.0 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1291030 MMP2 PECAM1 MMP2-PECAM1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.7246143201962468e-06 0.0 0.6331674633943454 0.0 0.0 0.0041555861088636 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1291031 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.7246143201962468e-06 0.0 0.6331674633943454 0.0 0.0 0.0041555861088636 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1291075 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.7233548667613683e-06 0.6626993710110988 0.0 0.0 0.0039530346951707 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1291160 COL4A2 CD93 COL4A2-CD93 B Cells Unassigned B Cells -> Unassigned 1.7215837480939915e-06 0.7783550150988336 0.0 0.0 0.0033449520260795 0.0 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1291283 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.718673990128552e-06 0.0 0.6632137581773894 0.0 0.0 0.0038860320327025 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1291327 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.7168937790767598e-06 0.0 0.6631822525600675 0.0 0.0 0.0038621268649178 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1291392 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Endothelial Cells Unassigned -> Endothelial Cells 1.7147495014436466e-06 0.0 0.773263018678637 0.0 0.0 0.0032875740549697 0.0 0.0 0.0 0.0 9 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1291400 DLL4 NOTCH3 DLL4-NOTCH3 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.7147061956510314e-06 0.7840818683779507 0.0 0.0 0.0032417203409647 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1291401 DLL4 NOTCH4 DLL4-NOTCH4 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.7147061956510314e-06 0.7840818683779507 0.0 0.0 0.0032417203409647 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1291436 CD48 CD2 CD48-CD2 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.7136904255525656e-06 0.0 0.6614977577544194 0.0 0.0 0.0038288178384739 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1291657 CD34 SELP CD34-SELP Unassigned Dendritic Cells Unassigned -> Dendritic Cells 1.7087687461971649e-06 0.0 0.7760344326192508 0.0 0.0 0.0032078747392388 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1291659 VWF SELP VWF-SELP Unassigned Dendritic Cells Unassigned -> Dendritic Cells 1.7087687461971649e-06 0.0 0.7760344326192508 0.0 0.0 0.0032078747392388 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1291704 CD48 CD2 CD48-CD2 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.7077232001098734e-06 0.6659645551150886 0.0 0.0 0.0037243679732516 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1291746 THBS2 CD36 THBS2-CD36 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.706700915659802e-06 0.0 0.2562573700401372 0.0 0.0 0.0096442330625583 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1291802 COL4A1 CD93 COL4A1-CD93 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.705845535679399e-06 0.6630837220165452 0.0 0.0 0.0037159398684439 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1291814 CD34 SELP CD34-SELP Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.7054513325182555e-06 0.0 0.4623922682986163 0.0 0.0 0.0053213839468185 0.0 0.0 0.0 0.0 6 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1291816 VWF SELP VWF-SELP Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.7054513325182555e-06 0.0 0.4623922682986163 0.0 0.0 0.0053213839468185 0.0 0.0 0.0 0.0 6 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1291881 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Mast Cells Unassigned -> Mast Cells 1.7028999720061797e-06 0.0 0.8381155706134242 0.0 0.0 0.0029095741067474 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1292133 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.6977660424205738e-06 0.0 0.7447682696221608 0.0 0.0 0.0032154705418133 0.0 0.0 0.0 0.0 6 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1292240 EFNB2 PECAM1 EFNB2-PECAM1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.6955012145099368e-06 0.4619393085577573 0.0 0.0 0.0051428381563772 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1292268 VWF LRP1 VWF-LRP1 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.6949519595348623e-06 0.0 0.7346293219749174 0.0 0.0 0.0032275631628407 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1292274 C1QB LRP1 C1QB-LRP1 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.6949519595348623e-06 0.0 0.7346293219749174 0.0 0.0 0.0032275631628407 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1292277 C3 LRP1 C3-LRP1 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.6949519595348623e-06 0.0 0.7346293219749174 0.0 0.0 0.0032275631628407 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1292289 HSPG2 LRP1 HSPG2-LRP1 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.6949519595348623e-06 0.0 0.7346293219749174 0.0 0.0 0.0032275631628407 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1292297 A2M LRP1 A2M-LRP1 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.6949519595348623e-06 0.0 0.7346293219749174 0.0 0.0 0.0032275631628407 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1292462 C1QB LRP1 C1QB-LRP1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.6902778648286418e-06 0.6626993710110988 0.0 0.0 0.0035190936623492 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1292469 HSPG2 LRP1 HSPG2-LRP1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.6901660678538545e-06 0.8818165186409654 0.0 0.0 0.0026436039558049 0.0 0.0 0.0 0.0 0.0 9 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1292472 VEGFC FLT1 VEGFC-FLT1 Macrophages Unassigned Macrophages -> Unassigned 1.690161816242798e-06 0.8963332422588541 0.0 0.0 0.0026007495851186 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1292573 EFNB2 PECAM1 EFNB2-PECAM1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.687970184411915e-06 0.8640667164982425 0.0 0.0 0.002676946692949 0.0 0.0 0.0 0.0 0.0 9 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1292591 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Mast Cells Unassigned -> Mast Cells 1.687483050361776e-06 0.0 0.836885603004631 0.0 0.0 0.0027591088867233 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1292714 VWF LRP1 VWF-LRP1 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.6850349080271046e-06 0.6332974881236617 0.0 0.0 0.0036144684673052 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1292716 VWF ITGA9 VWF-ITGA9 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.6850349080271046e-06 0.6332974881236617 0.0 0.0 0.0036144684673052 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1292721 VWF SELP VWF-SELP T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.6850349080271046e-06 0.6332974881236617 0.0 0.0 0.0036144684673052 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1292845 COL4A1 CD93 COL4A1-CD93 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.6821274819966774e-06 0.0 0.4630027772793905 0.0 0.0 0.0048929293424311 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1292846 MMRN2 CD93 MMRN2-CD93 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.6821274819966774e-06 0.0 0.4630027772793905 0.0 0.0 0.0048929293424311 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1292850 COL4A2 CD93 COL4A2-CD93 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.6821274819966774e-06 0.0 0.4630027772793905 0.0 0.0 0.0048929293424311 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1292985 HSPG2 LRP1 HSPG2-LRP1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.6788103790266775e-06 0.6589792304505506 0.0 0.0 0.0033973231723341 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1293050 CLEC2D KLRB1 CLEC2D-KLRB1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.6769721450588312e-06 0.7475533330314548 0.0 0.0 0.0029751676683741 0.0 0.0 0.0 0.0 0.0 1 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1293218 COL4A2 CD93 COL4A2-CD93 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.6723251584274262e-06 0.4630253981438691 0.0 0.0 0.0047240947268779 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1293328 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells Unassigned 11q13 Invasive Tumor Cells -> Unassigned 1.6684876133509286e-06 0.6242573126045354 0.0 0.0 0.0034559943126159 0.0 0.0 0.0 0.0 0.0 5 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1293400 CCN1 CAV1 CCN1-CAV1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.666407171400011e-06 0.0 0.62431395375366 0.0 0.0 0.0034299077593249 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1293653 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.6615677903815476e-06 0.0 0.6571792026963191 0.0 0.0 0.0032020139126304 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1293686 C3 LRP1 C3-LRP1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.6606480624339715e-06 0.7148920381722296 0.0 0.0 0.0029337538459309 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1293803 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Dendritic Cells Unassigned -> Dendritic Cells 1.6572563843168055e-06 0.0 0.6347970925105053 0.0 0.0 0.003263637675389 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1293985 HSPG2 LRP1 HSPG2-LRP1 Macrophages Unassigned Macrophages -> Unassigned 1.6544244707403348e-06 0.9253089325030373 0.0 0.0 0.0022161183602947 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1294014 VWF SELP VWF-SELP Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.6537469457175854e-06 0.0 0.7478729882108823 0.0 0.0 0.0027351735586246 0.0 0.0 0.0 0.0 6 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1294016 CD34 SELP CD34-SELP Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.6537469457175854e-06 0.0 0.7478729882108823 0.0 0.0 0.0027351735586246 0.0 0.0 0.0 0.0 6 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1294056 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.6528507972292116e-06 0.0 0.7830372268649692 0.0 0.0 0.0026038611777234 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1294058 MMP2 PECAM1 MMP2-PECAM1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.6527261216403386e-06 0.0 0.6331674633943454 0.0 0.0 0.0032187363284526 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1294059 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.6527261216403386e-06 0.0 0.6331674633943454 0.0 0.0 0.0032187363284526 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1294244 THBS2 CD36 THBS2-CD36 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.6495316728173107e-06 0.0 0.6176321640000088 0.0 0.0 0.0032616151102094 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1294247 VWF SELP VWF-SELP Unassigned Macrophages Unassigned -> Macrophages 1.649480116926102e-06 0.0 0.941479368642921 0.0 0.0 0.0021392900294222 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1294251 CD34 SELP CD34-SELP Unassigned Macrophages Unassigned -> Macrophages 1.649480116926102e-06 0.0 0.941479368642921 0.0 0.0 0.0021392900294222 0.0 0.0 0.0 0.0 4 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1294271 THBS2 CD36 THBS2-CD36 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 1.649402027951031e-06 0.724503440376099 0.0 0.0 0.0027791828709671 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1294278 MMRN2 CD93 MMRN2-CD93 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.6492597003756665e-06 0.6301823358791634 0.0 0.0 0.0031934983073077 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1294279 MMRN2 CLEC14A MMRN2-CLEC14A T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.6492597003756665e-06 0.6301823358791634 0.0 0.0 0.0031934983073077 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1294396 VEGFC FLT1 VEGFC-FLT1 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.6464133509567156e-06 0.0 0.4630488285702799 0.0 0.0 0.0043013567716651 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1294536 THBS2 CD36 THBS2-CD36 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.6419868544428717e-06 0.0 0.6176321640000088 0.0 0.0 0.0031731220372828 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1294694 CD48 CD2 CD48-CD2 Unassigned Pericytes Unassigned -> Pericytes 1.637491740800238e-06 0.0 0.7763428264267787 0.0 0.0 0.0024832440877005 0.0 0.0 0.0 0.0 7 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1294931 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.6333129485318567e-06 0.0 0.4641352222874551 0.0 0.0 0.0040904475843412 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1294944 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.6332553083964449e-06 0.0 0.7167436199046466 0.0 0.0 0.0026482500471321 0.0 0.0 0.0 0.0 6 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1294946 MMP2 PECAM1 MMP2-PECAM1 Unassigned Myoepithelial Cells Unassigned -> Myoepithelial Cells 1.6332553083964449e-06 0.0 0.7167436199046466 0.0 0.0 0.0026482500471321 0.0 0.0 0.0 0.0 6 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1295007 MMP2 PECAM1 MMP2-PECAM1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.6327889963385427e-06 0.0 0.2491073778594529 0.0 0.0 0.0076066460958003 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1295009 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Luminal-like Amorphous DCIS Cells Unassigned -> Luminal-like Amorphous DCIS Cells 1.6327889963385427e-06 0.0 0.2491073778594529 0.0 0.0 0.0076066460958003 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1295023 THBS2 CD36 THBS2-CD36 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.632763486728567e-06 0.0 0.6176321640000088 0.0 0.0 0.0030676679668133 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1295134 VWF ITGA9 VWF-ITGA9 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.6305994138274356e-06 0.0 0.950463483645931 0.0 0.0 0.0019776346124415 0.0 0.0 0.0 0.0 10 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1295182 CCN1 CAV1 CCN1-CAV1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.6297332437515823e-06 0.7324582304061453 0.0 0.0 0.0025580826958339 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1295366 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.6256446688135252e-06 0.0 0.6631822525600675 0.0 0.0 0.0027830389352876 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1295598 DLL4 NOTCH3 DLL4-NOTCH3 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.6214021555181251e-06 0.6342079770588467 0.0 0.0 0.0028649117803088 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1295601 DLL4 NOTCH4 DLL4-NOTCH4 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.6214021555181251e-06 0.6342079770588467 0.0 0.0 0.0028649117803088 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1295638 VWF SELP VWF-SELP Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 1.6200466748345397e-06 0.7158082793127664 0.0 0.0 0.0025256125075084 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1295643 VWF ITGA9 VWF-ITGA9 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 1.6200466748345397e-06 0.7158082793127664 0.0 0.0 0.0025256125075084 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1295645 VWF LRP1 VWF-LRP1 Myoepithelial Cells Unassigned Myoepithelial Cells -> Unassigned 1.6200466748345397e-06 0.7158082793127664 0.0 0.0 0.0025256125075084 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1295881 C1QB LRP1 C1QB-LRP1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.6169101204483936e-06 0.0 0.6207977546603366 0.0 0.0 0.0028784826949613 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1295884 A2M LRP1 A2M-LRP1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.6169101204483936e-06 0.0 0.6207977546603366 0.0 0.0 0.0028784826949613 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1295898 HSPG2 LRP1 HSPG2-LRP1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.6169101204483936e-06 0.0 0.6207977546603366 0.0 0.0 0.0028784826949613 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1295900 VWF LRP1 VWF-LRP1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.6169101204483936e-06 0.0 0.6207977546603366 0.0 0.0 0.0028784826949613 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1295904 C3 LRP1 C3-LRP1 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.6169101204483936e-06 0.0 0.6207977546603366 0.0 0.0 0.0028784826949613 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1296164 MMRN2 CLEC14A MMRN2-CLEC14A Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.612986022841596e-06 0.250044481781731 0.0 0.0 0.0070431301838115 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1296165 MMRN2 CD93 MMRN2-CD93 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.612986022841596e-06 0.250044481781731 0.0 0.0 0.0070431301838115 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1296248 MMP2 PECAM1 MMP2-PECAM1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.6110246155685818e-06 0.718867305289982 0.0 0.0 0.0024319941937022 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1296327 DLL1 NOTCH3 DLL1-NOTCH3 Mast Cells Unassigned Mast Cells -> Unassigned 1.608768557245365e-06 0.8624864526942296 0.0 0.0 0.0020100505037262 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1296393 COL4A1 CD93 COL4A1-CD93 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.607300666397919e-06 0.0 0.6587114738285964 0.0 0.0 0.0026174949623928 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1296400 COL4A2 CD93 COL4A2-CD93 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.607300666397919e-06 0.0 0.6587114738285964 0.0 0.0 0.0026174949623928 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1296401 MMRN2 CD93 MMRN2-CD93 Unassigned 11q13 Invasive Tumor Cells (Mitotic) Unassigned -> 11q13 Invasive Tumor Cells (Mitotic) 1.607300666397919e-06 0.0 0.6587114738285964 0.0 0.0 0.0026174949623928 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1296506 DLL4 NOTCH3 DLL4-NOTCH3 Macrophages Unassigned Macrophages -> Unassigned 1.60297308083997e-06 0.8949858186325867 0.0 0.0 0.001895566065636 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1296507 DLL4 NOTCH4 DLL4-NOTCH4 Macrophages Unassigned Macrophages -> Unassigned 1.60297308083997e-06 0.8949858186325867 0.0 0.0 0.001895566065636 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1296565 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Macrophages Unassigned -> Macrophages 1.6016588197090937e-06 0.0 0.8923034233058523 0.0 0.0 0.00189193058407 0.0 0.0 0.0 0.0 4 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1296567 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Macrophages Unassigned -> Macrophages 1.6016588197090937e-06 0.0 0.8923034233058523 0.0 0.0 0.00189193058407 0.0 0.0 0.0 0.0 4 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1296596 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.6013002854581304e-06 0.0 0.7462743270426613 0.0 0.0 0.0022591041672132 0.0 0.0 0.0 0.0 6 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1296874 DLL1 NOTCH3 DLL1-NOTCH3 B Cells Unassigned B Cells -> Unassigned 1.5949518687095388e-06 0.6249837837987587 0.0 0.0 0.00263399584678 0.0 0.0 0.0 0.0 0.0 2 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1297178 CD48 CD2 CD48-CD2 Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.5880962213981932e-06 0.0 0.6614977577544194 0.0 0.0 0.0024251058581756 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1297327 CD34 SELP CD34-SELP CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.5821569804079282e-06 0.9303167350027568 0.0 0.0 0.0016860250240652 0.0 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1297351 CXCL12 CXCR4 CXCL12-CXCR4 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.581539502980358e-06 0.255669001367946 0.0 0.0 0.0061207051981986 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1297362 CXCL12 ITGA4 CXCL12-ITGA4 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.581539502980358e-06 0.255669001367946 0.0 0.0 0.0061207051981986 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1297368 MMP2 PECAM1 MMP2-PECAM1 B Cells Unassigned B Cells -> Unassigned 1.5814874215774796e-06 0.6303642896310324 0.0 0.0 0.0024819960935566 0.0 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1297441 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.5794488335075623e-06 0.6301823358791634 0.0 0.0 0.0024635726452692 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1297443 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.5794488335075623e-06 0.6301823358791634 0.0 0.0 0.0024635726452692 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1297576 VEGFC FLT1 VEGFC-FLT1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.577422356048775e-06 0.8718210606749883 0.0 0.0 0.0017670878089588 0.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1297600 VEGFC FLT1 VEGFC-FLT1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.576970408256793e-06 0.743507317541692 0.0 0.0 0.0020684923107111 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1297971 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.5691597688363429e-06 0.0 0.6331674633943454 0.0 0.0 0.0023576674662702 0.0 0.0 0.0 0.0 3 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1297973 MMP2 PECAM1 MMP2-PECAM1 Unassigned Basal-like Structured DCIS Cells Unassigned -> Basal-like Structured DCIS Cells 1.5691597688363429e-06 0.0 0.6331674633943454 0.0 0.0 0.0023576674662702 0.0 0.0 0.0 0.0 3 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1298209 COL4A1 CD93 COL4A1-CD93 B Cells Unassigned B Cells -> Unassigned 1.5636738751125677e-06 0.8684504425765611 0.0 0.0 0.0016831757123532 0.0 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1298362 CCN1 CAV1 CCN1-CAV1 B Cells Unassigned B Cells -> Unassigned 1.558789875415492e-06 0.6213271600240247 0.0 0.0 0.0023088899408624 0.0 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1298386 JAG1 NOTCH2 JAG1-NOTCH2 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.5580559382724617e-06 0.8630183004227985 0.0 0.0 0.0016575843792215 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1298643 DLL4 NOTCH3 DLL4-NOTCH3 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 1.5511551649375107e-06 0.6342079770588467 0.0 0.0 0.002196330917593 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1298644 DLL4 NOTCH4 DLL4-NOTCH4 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 1.5511551649375107e-06 0.6342079770588467 0.0 0.0 0.002196330917593 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1298663 CD34 SELP CD34-SELP Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.550386930875404e-06 0.0 0.6572093097629401 0.0 0.0 0.002113171886167 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1298664 VWF SELP VWF-SELP Unassigned CAFs, Invasive Associated Unassigned -> CAFs, Invasive Associated 1.550386930875404e-06 0.0 0.6572093097629401 0.0 0.0 0.002113171886167 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1298828 THBS2 CD36 THBS2-CD36 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.546742674588831e-06 0.0 0.7763054211764489 0.0 0.0 0.0017638974017382 0.0 0.0 0.0 0.0 6 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1299346 CXCL12 ITGA4 CXCL12-ITGA4 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.5356721600673158e-06 0.6160088550075702 0.0 0.0 0.0021291294377375 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1299347 CXCL12 CXCR4 CXCL12-CXCR4 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.5356721600673158e-06 0.6160088550075702 0.0 0.0 0.0021291294377375 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1299397 CD34 SELP CD34-SELP Plasma Cells Unassigned Plasma Cells -> Unassigned 1.534407129109318e-06 0.7168245244832976 0.0 0.0 0.0018206581062216 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1299586 VWF ITGA9 VWF-ITGA9 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.5299584059288408e-06 0.6332974881236617 0.0 0.0 0.0020251995753771 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1299590 VWF SELP VWF-SELP Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.5299584059288408e-06 0.6332974881236617 0.0 0.0 0.0020251995753771 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1299591 VWF LRP1 VWF-LRP1 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.5299584059288408e-06 0.6332974881236617 0.0 0.0 0.0020251995753771 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1299605 DLL1 NOTCH3 DLL1-NOTCH3 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 1.5296217145154305e-06 0.2534163760166434 0.0 0.0 0.0050543892975134 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1299621 THBS2 CD36 THBS2-CD36 Basal-like Structured DCIS Cells Unassigned Basal-like Structured DCIS Cells -> Unassigned 1.529289654365763e-06 0.6242573126045354 0.0 0.0 0.0020491452254277 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1299660 VEGFC FLT1 VEGFC-FLT1 Unassigned Mast Cells Unassigned -> Mast Cells 1.5278373518987772e-06 0.0 0.8331580262014722 0.0 0.0 0.001526625481682 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1299755 VWF SELP VWF-SELP Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.5251343057254372e-06 0.6332974881236617 0.0 0.0 0.0019871862905238 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1299759 VWF ITGA9 VWF-ITGA9 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.5251343057254372e-06 0.6332974881236617 0.0 0.0 0.0019871862905238 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1299760 VWF LRP1 VWF-LRP1 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.5251343057254372e-06 0.6332974881236617 0.0 0.0 0.0019871862905238 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1299766 CD48 CD2 CD48-CD2 Unassigned Macrophages Unassigned -> Macrophages 1.5250385259284926e-06 0.0 0.7763428264267787 0.0 0.0 0.0016204239758814 0.0 0.0 0.0 0.0 4 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1299823 MMP2 PECAM1 MMP2-PECAM1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.5224766587285725e-06 0.2491408586098361 0.0 0.0 0.0049987108499989 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1299854 C1QB LRP1 C1QB-LRP1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.5213643808839286e-06 0.4601010570874773 0.0 0.0 0.0026949121497638 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1299866 HSPG2 LRP1 HSPG2-LRP1 Mast Cells Unassigned Mast Cells -> Unassigned 1.5205992539523164e-06 0.8349903778527206 0.0 0.0 0.0014804857410621 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1299891 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.5201608415262133e-06 0.0 0.7754239189773715 0.0 0.0 0.0015914585039484 0.0 0.0 0.0 0.0 10 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1299971 CXCL12 CXCR4 CXCL12-CXCR4 Mast Cells Unassigned Mast Cells -> Unassigned 1.5191801880325264e-06 0.7487535481622718 0.0 0.0 0.0016417770622885 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1299978 CXCL12 ITGA4 CXCL12-ITGA4 Mast Cells Unassigned Mast Cells -> Unassigned 1.5191801880325264e-06 0.7487535481622718 0.0 0.0 0.0016417770622885 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1300066 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.516944020302238e-06 0.0 0.885766439573873 0.0 0.0 0.0013756087909864 0.0 0.0 0.0 0.0 10 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1300094 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Macrophages Unassigned -> Macrophages 1.5166483541793962e-06 0.0 0.9195415044619336 0.0 0.0 0.0013235329769289 0.0 0.0 0.0 0.0 4 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1300150 A2M LRP1 A2M-LRP1 B Cells Unassigned B Cells -> Unassigned 1.5156711005126588e-06 0.7741139100414175 0.0 0.0 0.0015661096645571 0.0 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1300202 CCN1 CAV1 CCN1-CAV1 Unassigned B Cells Unassigned -> B Cells 1.5141771667381498e-06 0.0 0.62431395375366 0.0 0.0 0.0019304335593669 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1300284 CXCL12 CXCR4 CXCL12-CXCR4 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.510262284092617e-06 0.7487535481622718 0.0 0.0 0.0015847932820241 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1300286 CXCL12 ITGA4 CXCL12-ITGA4 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.510262284092617e-06 0.7487535481622718 0.0 0.0 0.0015847932820241 0.0 0.0 0.0 0.0 0.0 1 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1300430 CD34 SELP CD34-SELP 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.5063080110369643e-06 0.633566764858408 0.0 0.0 0.0018436902762588 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1300656 CD48 CD2 CD48-CD2 Unassigned Mast Cells Unassigned -> Mast Cells 1.5012974987840295e-06 0.0 0.7763428264267787 0.0 0.0 0.0014748371602574 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1300696 EFNB2 PECAM1 EFNB2-PECAM1 B Cells Unassigned B Cells -> Unassigned 1.5003491065163535e-06 0.7800321422220979 0.0 0.0 0.0014623066995027 0.0 0.0 0.0 0.0 0.0 2 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1300857 A2M LRP1 A2M-LRP1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.4965683863093105e-06 0.0 0.6207977546603366 0.0 0.0 0.0018097844702233 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1300869 VWF LRP1 VWF-LRP1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.4965683863093105e-06 0.0 0.6207977546603366 0.0 0.0 0.0018097844702233 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1300879 HSPG2 LRP1 HSPG2-LRP1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.4965683863093105e-06 0.0 0.6207977546603366 0.0 0.0 0.0018097844702233 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1300889 C3 LRP1 C3-LRP1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.4965683863093105e-06 0.0 0.6207977546603366 0.0 0.0 0.0018097844702233 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1300893 C1QB LRP1 C1QB-LRP1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.4965683863093105e-06 0.0 0.6207977546603366 0.0 0.0 0.0018097844702233 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1300990 CD48 CD2 CD48-CD2 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.4935419026389355e-06 0.7719609236370527 0.0 0.0 0.0014378253178126 0.0 0.0 0.0 0.0 0.0 9 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1301403 VEGFC FLT1 VEGFC-FLT1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.4849599620499824e-06 0.4636527906642655 0.0 0.0 0.0023125636768155 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1301468 CCN1 CAV1 CCN1-CAV1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.4834753395650375e-06 0.0 0.7832252605020791 0.0 0.0 0.00136079311934 0.0 0.0 0.0 0.0 6 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1301593 VWF SELP VWF-SELP Unassigned Plasma Cells Unassigned -> Plasma Cells 1.4776863600442563e-06 0.0 0.4623922682986163 0.0 0.0 0.0022515473538965 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1301595 CD34 SELP CD34-SELP Unassigned Plasma Cells Unassigned -> Plasma Cells 1.4776863600442563e-06 0.0 0.4623922682986163 0.0 0.0 0.0022515473538965 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1301642 VWF LRP1 VWF-LRP1 Unassigned B Cells Unassigned -> B Cells 1.4761794904376593e-06 0.0 0.6207977546603366 0.0 0.0 0.0016667952436519 0.0 0.0 0.0 0.0 2 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1301656 A2M LRP1 A2M-LRP1 Unassigned B Cells Unassigned -> B Cells 1.4761794904376593e-06 0.0 0.6207977546603366 0.0 0.0 0.0016667952436519 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1301663 C3 LRP1 C3-LRP1 Unassigned B Cells Unassigned -> B Cells 1.4761794904376593e-06 0.0 0.6207977546603366 0.0 0.0 0.0016667952436519 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1301665 C1QB LRP1 C1QB-LRP1 Unassigned B Cells Unassigned -> B Cells 1.4761794904376593e-06 0.0 0.6207977546603366 0.0 0.0 0.0016667952436519 0.0 0.0 0.0 0.0 2 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1301673 HSPG2 LRP1 HSPG2-LRP1 Unassigned B Cells Unassigned -> B Cells 1.4761794904376593e-06 0.0 0.6207977546603366 0.0 0.0 0.0016667952436519 0.0 0.0 0.0 0.0 2 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1301721 MMP2 PECAM1 MMP2-PECAM1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.4742645929138932e-06 0.0 0.7841656220878274 0.0 0.0 0.001309307002134 0.0 0.0 0.0 0.0 6 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1301723 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.4742645929138932e-06 0.0 0.7841656220878274 0.0 0.0 0.001309307002134 0.0 0.0 0.0 0.0 6 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1301752 VWF LRP1 VWF-LRP1 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 1.4736441183364564e-06 0.6332974881236617 0.0 0.0 0.0016171311116606 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1301757 VWF ITGA9 VWF-ITGA9 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 1.4736441183364564e-06 0.6332974881236617 0.0 0.0 0.0016171311116606 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1301758 VWF SELP VWF-SELP CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 1.4736441183364564e-06 0.6332974881236617 0.0 0.0 0.0016171311116606 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1301781 VWF ITGA9 VWF-ITGA9 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 1.473518475843081e-06 0.0 0.2531744428854943 0.0 0.0 0.0040430820937484 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1301824 A2M LRP1 A2M-LRP1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.472210122834052e-06 0.4648000335061383 0.0 0.0 0.0021905373114471 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1301864 COL4A1 CD93 COL4A1-CD93 Unassigned Mast Cells Unassigned -> Mast Cells 1.4702032462137507e-06 0.0 0.8347945881127203 0.0 0.0 0.0012097093680331 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1301865 MMRN2 CD93 MMRN2-CD93 Unassigned Mast Cells Unassigned -> Mast Cells 1.4702032462137507e-06 0.0 0.8347945881127203 0.0 0.0 0.0012097093680331 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1301873 COL4A2 CD93 COL4A2-CD93 Unassigned Mast Cells Unassigned -> Mast Cells 1.4702032462137507e-06 0.0 0.8347945881127203 0.0 0.0 0.0012097093680331 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1301879 EFNB2 PECAM1 EFNB2-PECAM1 Mast Cells Unassigned Mast Cells -> Unassigned 1.4701691099843205e-06 0.8284725546778968 0.0 0.0 0.0012187708721425 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1301897 HSPG2 LRP1 HSPG2-LRP1 B Cells Unassigned B Cells -> Unassigned 1.4697607663242837e-06 0.7789175740361626 0.0 0.0 0.0012941512528773 0.0 0.0 0.0 0.0 0.0 2 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1302047 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.4653038342067208e-06 0.0 0.4614667734221426 0.0 0.0 0.0021449819680126 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1302059 VEGFC FLT1 VEGFC-FLT1 Unassigned B Cells Unassigned -> B Cells 1.465112281807866e-06 0.0 0.777821334064334 0.0 0.0 0.001271575589586 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1302081 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.4644053059496224e-06 0.6332974881236617 0.0 0.0 0.0015572459193676 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1302083 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.4644053059496224e-06 0.6332974881236617 0.0 0.0 0.0015572459193676 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1302085 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.4644053059496224e-06 0.6332974881236617 0.0 0.0 0.0015572459193676 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1302126 THBS2 CD36 THBS2-CD36 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.4628233588659724e-06 0.0 0.8587566561291643 0.0 0.0 0.0011409783203169 0.0 0.0 0.0 0.0 10 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1302182 MMRN2 CD93 MMRN2-CD93 Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.4606454573829087e-06 0.6301823358791634 0.0 0.0 0.0015409900107563 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1302183 MMRN2 CLEC14A MMRN2-CLEC14A Dendritic Cells Unassigned Dendritic Cells -> Unassigned 1.4606454573829087e-06 0.6301823358791634 0.0 0.0 0.0015409900107563 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1302241 VEGFC FLT1 VEGFC-FLT1 B Cells Unassigned B Cells -> Unassigned 1.45914673962623e-06 0.7745997874735252 0.0 0.0 0.0012459853895406 0.0 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1302342 CD48 CD2 CD48-CD2 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.4567884539784695e-06 0.0 0.7464347811605867 0.0 0.0 0.0012805120781881 0.0 0.0 0.0 0.0 6 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1302378 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.4554503018480133e-06 0.0 0.7757991160529997 0.0 0.0 0.0012252690191386 0.0 0.0 0.0 0.0 10 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1302417 C1QB LRP1 C1QB-LRP1 Mast Cells Unassigned Mast Cells -> Unassigned 1.4545359680288445e-06 0.7753420160918723 0.0 0.0 0.0012213774841743 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1302473 COL4A2 CD93 COL4A2-CD93 Mast Cells Unassigned Mast Cells -> Unassigned 1.4524746275880791e-06 0.8355319038299565 0.0 0.0 0.001123788079051 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1302544 COL4A1 CD93 COL4A1-CD93 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.4495545855895387e-06 0.7463064942968751 0.0 0.0 0.0012430446376512 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1302556 MMRN2 CLEC14A MMRN2-CLEC14A CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 1.4490277262190364e-06 0.6301823358791634 0.0 0.0 0.00146889578236 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1302558 MMRN2 CD93 MMRN2-CD93 CAFs, Invasive Associated Unassigned CAFs, Invasive Associated -> Unassigned 1.4490277262190364e-06 0.6301823358791634 0.0 0.0 0.00146889578236 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1302630 C3 LRP1 C3-LRP1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.4473473501314787e-06 0.2485046029682279 0.0 0.0 0.0036991419150414 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1302662 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.444837155755546e-06 0.6303642896310324 0.0 0.0 0.0014431743145616 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1302667 C1QB LRP1 C1QB-LRP1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.4446935611978e-06 0.7452691992612583 0.0 0.0 0.0012199377895337 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1302796 CCN1 CAV1 CCN1-CAV1 Unassigned Mast Cells Unassigned -> Mast Cells 1.441577600981056e-06 0.0 0.8617632615906476 0.0 0.0 0.0010414441948928 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1302962 DLL4 NOTCH4 DLL4-NOTCH4 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.4371741280892884e-06 0.7160288858520609 0.0 0.0 0.0012306151710811 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1302963 DLL4 NOTCH3 DLL4-NOTCH3 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.4371741280892884e-06 0.7160288858520609 0.0 0.0 0.0012306151710811 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1303357 COL4A1 CD93 COL4A1-CD93 Unassigned B Cells Unassigned -> B Cells 1.4257687249615482e-06 0.0 0.7779918296243433 0.0 0.0 0.001079730675535 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1303358 COL4A2 CD93 COL4A2-CD93 Unassigned B Cells Unassigned -> B Cells 1.4257687249615482e-06 0.0 0.7779918296243433 0.0 0.0 0.001079730675535 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1303360 MMRN2 CD93 MMRN2-CD93 Unassigned B Cells Unassigned -> B Cells 1.4257687249615482e-06 0.0 0.7779918296243433 0.0 0.0 0.001079730675535 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1303420 VWF SELP VWF-SELP Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.424043307855731e-06 0.2486570577556728 0.0 0.0 0.0033537993821664 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1303422 VWF LRP1 VWF-LRP1 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.424043307855731e-06 0.2486570577556728 0.0 0.0 0.0033537993821664 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1303423 VWF ITGA9 VWF-ITGA9 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.424043307855731e-06 0.2486570577556728 0.0 0.0 0.0033537993821664 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1303554 MMP2 PECAM1 MMP2-PECAM1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.4189495707919143e-06 0.785133132759182 0.0 0.0 0.001039571291679 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1303745 VWF SELP VWF-SELP Macrophages Unassigned Macrophages -> Unassigned 1.4134837772469891e-06 0.9011206516381156 0.0 0.0 0.0008850282134344 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1303746 VWF ITGA9 VWF-ITGA9 Macrophages Unassigned Macrophages -> Unassigned 1.4134837772469891e-06 0.9011206516381156 0.0 0.0 0.0008850282134344 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1303750 VWF LRP1 VWF-LRP1 Macrophages Unassigned Macrophages -> Unassigned 1.4134837772469891e-06 0.9011206516381156 0.0 0.0 0.0008850282134344 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1303777 COL4A1 CD93 COL4A1-CD93 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.4125564259613162e-06 0.4604235282221027 0.0 0.0 0.0017253404164066 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1303969 COL4A2 CD93 COL4A2-CD93 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.406833726113861e-06 0.0 0.7461459456652184 0.0 0.0 0.0010390313650636 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1303975 MMRN2 CD93 MMRN2-CD93 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.406833726113861e-06 0.0 0.7461459456652184 0.0 0.0 0.0010390313650636 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1303976 COL4A1 CD93 COL4A1-CD93 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.406833726113861e-06 0.0 0.7461459456652184 0.0 0.0 0.0010390313650636 0.0 0.0 0.0 0.0 6 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1304104 A2M LRP1 A2M-LRP1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.401629813332874e-06 0.7460047258226694 0.0 0.0 0.0010163752993685 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1304165 CD34 SELP CD34-SELP Unassigned Mast Cells Unassigned -> Mast Cells 1.4005665173743837e-06 0.0 0.8347297932672282 0.0 0.0 0.0009042150166242 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1304166 VWF SELP VWF-SELP Unassigned Mast Cells Unassigned -> Mast Cells 1.4005665173743837e-06 0.0 0.8347297932672282 0.0 0.0 0.0009042150166242 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1304438 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.3905389503179528e-06 0.0 0.6347970925105053 0.0 0.0 0.0011388334136451 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1304460 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned B Cells Unassigned -> B Cells 1.3900451696149585e-06 0.0 0.8445107771175474 0.0 0.0 0.0008542071298387 0.0 0.0 0.0 0.0 2 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1304476 THBS2 CD36 THBS2-CD36 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.3895455088704849e-06 0.0 0.7373999388878224 0.0 0.0 0.0009761781830445 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1304484 CCN1 CAV1 CCN1-CAV1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.3889892399558235e-06 0.7797135509308979 0.0 0.0 0.0009209869688402 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1304522 CD34 SELP CD34-SELP Mast Cells Unassigned Mast Cells -> Unassigned 1.3879198158329566e-06 0.8532069650852002 0.0 0.0 0.00083777361258 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1304526 CLEC2D KLRB1 CLEC2D-KLRB1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.3878643246290745e-06 0.8721681415062816 0.0 0.0 0.0008193633790489 0.0 0.0 0.0 0.0 0.0 9 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1304561 C1QB LRP1 C1QB-LRP1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.386279527974895e-06 0.7753420160918723 0.0 0.0 0.0009153913192522 0.0 0.0 0.0 0.0 0.0 9 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1304564 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.3862127416324858e-06 0.0 0.9003264838243337 0.0 0.0 0.0007880862995141 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1304583 THBS2 CD36 THBS2-CD36 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.3848739930129698e-06 0.724503440376099 0.0 0.0 0.0009736808737186 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1304771 MMRN2 CLEC14A MMRN2-CLEC14A Macrophages Unassigned Macrophages -> Unassigned 1.3787957426241329e-06 0.893316592628645 0.0 0.0 0.0007691101630988 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1304772 MMRN2 CD93 MMRN2-CD93 Macrophages Unassigned Macrophages -> Unassigned 1.3787957426241329e-06 0.893316592628645 0.0 0.0 0.0007691101630988 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1304778 CD34 SELP CD34-SELP Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.3780225017138715e-06 0.0 0.6572093097629401 0.0 0.0 0.0010419094417808 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1304779 VWF SELP VWF-SELP Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.3780225017138715e-06 0.0 0.6572093097629401 0.0 0.0 0.0010419094417808 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1304860 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Plasma Cells Unassigned -> Plasma Cells 1.3747803683678438e-06 0.0 0.7154802332407408 0.0 0.0 0.0009436211854823 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1304967 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.371576091683793e-06 0.0 0.773263018678637 0.0 0.0 0.0008609682710384 0.0 0.0 0.0 0.0 10 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1305199 C3 LRP1 C3-LRP1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.3622403977679071e-06 0.7796725988275006 0.0 0.0 0.000819605673545 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1305627 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.3469082743721877e-06 0.6160088550075702 0.0 0.0 0.0009692519480124 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1305631 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.3469082743721877e-06 0.6160088550075702 0.0 0.0 0.0009692519480124 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1305645 MMP2 PECAM1 MMP2-PECAM1 Mast Cells Unassigned Mast Cells -> Unassigned 1.3466420623245808e-06 0.8560892486218385 0.0 0.0 0.0006966068981631 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1305699 HSPG2 LRP1 HSPG2-LRP1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.345484908632677e-06 0.4629984640915818 0.0 0.0 0.0012814156885439 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1305710 JAG1 NOTCH2 JAG1-NOTCH2 T Lymphocytes Unassigned T Lymphocytes -> Unassigned 1.344885237958043e-06 0.8630183004227985 0.0 0.0 0.0006856224272495 0.0 0.0 0.0 0.0 0.0 1 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1305856 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.3390009448748373e-06 0.0 0.7470475610360806 0.0 0.0 0.0007714919761827 0.0 0.0 0.0 0.0 6 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1305865 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.3390009448748373e-06 0.0 0.7470475610360806 0.0 0.0 0.0007714919761827 0.0 0.0 0.0 0.0 6 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1305955 DLL4 NOTCH3 DLL4-NOTCH3 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.3358182143862368e-06 0.6342079770588467 0.0 0.0 0.000895875398841 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1305956 DLL4 NOTCH4 DLL4-NOTCH4 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.3358182143862368e-06 0.6342079770588467 0.0 0.0 0.000895875398841 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1306088 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned B Cells Unassigned -> B Cells 1.331090325489018e-06 0.0 0.7746834992804791 0.0 0.0 0.00071798405859 0.0 0.0 0.0 0.0 2 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1306091 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned B Cells Unassigned -> B Cells 1.331090325489018e-06 0.0 0.7746834992804791 0.0 0.0 0.00071798405859 0.0 0.0 0.0 0.0 2 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1306291 C3 LRP1 C3-LRP1 Mast Cells Unassigned Mast Cells -> Unassigned 1.3231233447500742e-06 0.8509500867818902 0.0 0.0 0.0006305085967044 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1306335 THBS2 CD36 THBS2-CD36 B Cells Unassigned B Cells -> Unassigned 1.321403642193188e-06 0.6242573126045354 0.0 0.0 0.0008527942416386 0.0 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1306405 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Mast Cells Unassigned -> Mast Cells 1.3186868323401177e-06 0.0 0.773263018678637 0.0 0.0 0.0006800116997025 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1306412 MMP2 PECAM1 MMP2-PECAM1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.3181284098709468e-06 0.6303642896310324 0.0 0.0 0.0008320501336843 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1306547 VEGFC FLT1 VEGFC-FLT1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.31128255176523e-06 0.0 0.878254460598671 0.0 0.0 0.0005788283879716 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1306626 HSPG2 LRP1 HSPG2-LRP1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.3074766012821404e-06 0.7468485855611411 0.0 0.0 0.0006689050756654 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1306732 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Mast Cells Unassigned -> Mast Cells 1.3027330192690912e-06 0.0 0.8514619504364779 0.0 0.0 0.0005740632036187 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1306898 COL4A1 CD93 COL4A1-CD93 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.298026272415595e-06 0.0 0.6587114738285964 0.0 0.0 0.0007261054236978 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1306901 COL4A2 CD93 COL4A2-CD93 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.298026272415595e-06 0.0 0.6587114738285964 0.0 0.0 0.0007261054236978 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1306908 MMRN2 CD93 MMRN2-CD93 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.298026272415595e-06 0.0 0.6587114738285964 0.0 0.0 0.0007261054236978 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1306912 CCN1 CAV1 CCN1-CAV1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 1.2978453294107687e-06 0.0 0.252518874138558 0.0 0.0 0.0018925243453249 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1307007 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned B Cells Unassigned -> B Cells 1.2947103189013064e-06 0.0 0.7754072541855492 0.0 0.0 0.0006074333625108 0.0 0.0 0.0 0.0 2 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1307036 THBS2 CD36 THBS2-CD36 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.2939423663888298e-06 0.0 0.6176321640000088 0.0 0.0 0.0007598956708367 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1307044 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.2935988578457632e-06 0.0 0.6331674633943454 0.0 0.0 0.0007400708115376 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1307045 MMP2 PECAM1 MMP2-PECAM1 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.2935988578457632e-06 0.0 0.6331674633943454 0.0 0.0 0.0007400708115376 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1307162 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.2891569857376446e-06 0.6319926036888139 0.0 0.0 0.0007263013575398 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1307249 VEGFC FLT1 VEGFC-FLT1 Mast Cells Unassigned Mast Cells -> Unassigned 1.286094506886724e-06 0.8317042416754105 0.0 0.0 0.0005440770361181 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1307258 MMRN2 CD93 MMRN2-CD93 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.285542757283613e-06 0.6301823358791634 0.0 0.0 0.000716220684292 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1307259 MMRN2 CLEC14A MMRN2-CLEC14A 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.285542757283613e-06 0.6301823358791634 0.0 0.0 0.000716220684292 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1307356 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.2785811935479007e-06 0.0 0.896164124004365 0.0 0.0 0.0004874986369898 0.0 0.0 0.0 0.0 10 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1307384 THBS2 CD36 THBS2-CD36 Unassigned B Cells Unassigned -> B Cells 1.277976262324739e-06 0.0 0.6176321640000088 0.0 0.0 0.0007053434767499 0.0 0.0 0.0 0.0 2 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1307398 MMRN2 CD93 MMRN2-CD93 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.2778875334060084e-06 0.7856500335676843 0.0 0.0 0.0005542667491398 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1307400 MMRN2 CLEC14A MMRN2-CLEC14A Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.2778875334060084e-06 0.7856500335676843 0.0 0.0 0.0005542667491398 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1307422 A2M LRP1 A2M-LRP1 Mast Cells Unassigned Mast Cells -> Unassigned 1.2769032434229793e-06 0.8392912392980421 0.0 0.0 0.0005164482812395 0.0 0.0 0.0 0.0 0.0 1 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1307443 HSPG2 LRP1 HSPG2-LRP1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.276142224794126e-06 0.0 0.7769451595923457 0.0 0.0 0.0005558995075445 0.0 0.0 0.0 0.0 6 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1307453 VWF LRP1 VWF-LRP1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.276142224794126e-06 0.0 0.7769451595923457 0.0 0.0 0.0005558995075445 0.0 0.0 0.0 0.0 6 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1307471 A2M LRP1 A2M-LRP1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.276142224794126e-06 0.0 0.7769451595923457 0.0 0.0 0.0005558995075445 0.0 0.0 0.0 0.0 6 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1307477 C1QB LRP1 C1QB-LRP1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.276142224794126e-06 0.0 0.7769451595923457 0.0 0.0 0.0005558995075445 0.0 0.0 0.0 0.0 6 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1307480 C3 LRP1 C3-LRP1 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.276142224794126e-06 0.0 0.7769451595923457 0.0 0.0 0.0005558995075445 0.0 0.0 0.0 0.0 6 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1307496 DLL4 NOTCH4 DLL4-NOTCH4 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.2758738031541834e-06 0.9184503888425788 0.0 0.0 0.0004696576149175 0.0 0.0 0.0 0.0 0.0 9 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1307498 DLL4 NOTCH3 DLL4-NOTCH3 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.2758738031541834e-06 0.9184503888425788 0.0 0.0 0.0004696576149175 0.0 0.0 0.0 0.0 0.0 9 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1307562 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.274709689467778e-06 0.0 0.4638256179742202 0.0 0.0 0.0009249287638231 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1307565 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.274709689467778e-06 0.0 0.4638256179742202 0.0 0.0 0.0009249287638231 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1307580 MMRN2 CD93 MMRN2-CD93 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.2741702484252938e-06 0.0 0.4630027772793905 0.0 0.0 0.0009242223287825 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1307584 COL4A2 CD93 COL4A2-CD93 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.2741702484252938e-06 0.0 0.4630027772793905 0.0 0.0 0.0009242223287825 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1307585 COL4A1 CD93 COL4A1-CD93 Unassigned Plasma Cells Unassigned -> Plasma Cells 1.2741702484252938e-06 0.0 0.4630027772793905 0.0 0.0 0.0009242223287825 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1307620 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned B Cells Unassigned -> B Cells 1.2732126662378282e-06 0.0 0.6347970925105053 0.0 0.0 0.000671064546954 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1308001 DLL4 NOTCH4 DLL4-NOTCH4 Mast Cells Unassigned Mast Cells -> Unassigned 1.2611303782908016e-06 0.8516956437178343 0.0 0.0 0.000472352586488 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1308002 DLL4 NOTCH3 DLL4-NOTCH3 Mast Cells Unassigned Mast Cells -> Unassigned 1.2611303782908016e-06 0.8516956437178343 0.0 0.0 0.000472352586488 0.0 0.0 0.0 0.0 0.0 1 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1308009 CD34 SELP CD34-SELP B Cells Unassigned B Cells -> Unassigned 1.260701084730796e-06 0.633566764858408 0.0 0.0 0.0006336851232098 0.0 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1308208 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Myeloid Cells Unassigned -> Myeloid Cells 1.2519352316401966e-06 0.0 0.7426180951053148 0.0 0.0 0.0005184623914895 0.0 0.0 0.0 0.0 6 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1308293 MMP2 PECAM1 MMP2-PECAM1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.24946592203688e-06 0.0 0.930308383061206 0.0 0.0 0.0004089864655001 0.0 0.0 0.0 0.0 10 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1308294 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.24946592203688e-06 0.0 0.930308383061206 0.0 0.0 0.0004089864655001 0.0 0.0 0.0 0.0 10 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1308304 CCN1 CAV1 CCN1-CAV1 Mast Cells Unassigned Mast Cells -> Unassigned 1.2489123422016206e-06 0.8749036366850302 0.0 0.0 0.0004337320404416 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1308328 THBS2 CD36 THBS2-CD36 Unassigned Mast Cells Unassigned -> Mast Cells 1.247275831465212e-06 0.0 0.8765901449012573 0.0 0.0 0.0004295051170816 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1308358 THBS2 CD36 THBS2-CD36 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.2454950773232369e-06 0.7809827257946271 0.0 0.0 0.0004779710276932 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1308373 CCN1 CAV1 CCN1-CAV1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 1.2451187209638575e-06 0.2542249848376565 0.0 0.0 0.0014656941948563 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1308460 VWF LRP1 VWF-LRP1 Unassigned Mast Cells Unassigned -> Mast Cells 1.2399115066711347e-06 0.0 0.8755243548400705 0.0 0.0 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1308464 A2M LRP1 A2M-LRP1 Unassigned Mast Cells Unassigned -> Mast Cells 1.2399115066711347e-06 0.0 0.8755243548400705 0.0 0.0 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1308472 HSPG2 LRP1 HSPG2-LRP1 Unassigned Mast Cells Unassigned -> Mast Cells 1.2399115066711347e-06 0.0 0.8755243548400705 0.0 0.0 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1308485 C1QB LRP1 C1QB-LRP1 Unassigned Mast Cells Unassigned -> Mast Cells 1.2399115066711347e-06 0.0 0.8755243548400705 0.0 0.0 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1308492 C3 LRP1 C3-LRP1 Unassigned Mast Cells Unassigned -> Mast Cells 1.2399115066711347e-06 0.0 0.8755243548400705 0.0 0.0 0.0004150165744076 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1308592 MMRN2 CD93 MMRN2-CD93 Mast Cells Unassigned Mast Cells -> Unassigned 1.2378527671845387e-06 0.8571898293845529 0.0 0.0 0.0004196880356983 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1308593 MMRN2 CLEC14A MMRN2-CLEC14A Mast Cells Unassigned Mast Cells -> Unassigned 1.2378527671845387e-06 0.8571898293845529 0.0 0.0 0.0004196880356983 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1308626 VWF SELP VWF-SELP Unassigned B Cells Unassigned -> B Cells 1.2354766464207508e-06 0.0 0.7760344326192508 0.0 0.0 0.0004582650848664 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1308627 CD34 SELP CD34-SELP Unassigned B Cells Unassigned -> B Cells 1.2354766464207508e-06 0.0 0.7760344326192508 0.0 0.0 0.0004582650848664 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1308651 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Mast Cells Unassigned -> Mast Cells 1.2341222645145283e-06 0.0 0.8537710813834968 0.0 0.0 0.0004138063814779 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1308652 MMP2 PECAM1 MMP2-PECAM1 Unassigned Mast Cells Unassigned -> Mast Cells 1.2341222645145283e-06 0.0 0.8537710813834968 0.0 0.0 0.0004138063814779 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1309065 C3 LRP1 C3-LRP1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 1.2162916242156178e-06 0.2485046029682279 0.0 0.0 0.0013028322726017 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1309176 VWF ITGA9 VWF-ITGA9 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.211289037669086e-06 0.7848266128497919 0.0 0.0 0.0004024409845247 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1309180 VWF LRP1 VWF-LRP1 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.211289037669086e-06 0.7848266128497919 0.0 0.0 0.0004024409845247 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1309181 VWF SELP VWF-SELP Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.211289037669086e-06 0.7848266128497919 0.0 0.0 0.0004024409845247 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1309377 COL4A2 CD93 COL4A2-CD93 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.199344727686071e-06 0.0 0.8817184225858201 0.0 0.0 0.0003375370073613 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1309380 MMRN2 CD93 MMRN2-CD93 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.199344727686071e-06 0.0 0.8817184225858201 0.0 0.0 0.0003375370073613 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1309383 COL4A1 CD93 COL4A1-CD93 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.199344727686071e-06 0.0 0.8817184225858201 0.0 0.0 0.0003375370073613 0.0 0.0 0.0 0.0 10 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1309805 JAG1 NOTCH2 JAG1-NOTCH2 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 1.1745280628781797e-06 0.2451358214448441 0.0 0.0 0.0010709508378277 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1309832 C3 LRP1 C3-LRP1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.171725751596502e-06 0.6319926036888139 0.0 0.0 0.0004094805141934 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1309990 VWF SELP VWF-SELP Plasma Cells Unassigned Plasma Cells -> Unassigned 1.1630330936920983e-06 0.7158082793127664 0.0 0.0 0.0003457348439318 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1309992 VWF LRP1 VWF-LRP1 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.1630330936920983e-06 0.7158082793127664 0.0 0.0 0.0003457348439318 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1309997 VWF ITGA9 VWF-ITGA9 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.1630330936920983e-06 0.7158082793127664 0.0 0.0 0.0003457348439318 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1310006 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (Mitotic) Unassigned 11q13 Invasive Tumor Cells (Mitotic) -> Unassigned 1.1615274112460747e-06 0.6242573126045354 0.0 0.0 0.000393370777602 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1310032 CD48 CD2 CD48-CD2 Unassigned 11q13 Invasive Tumor Cells (G1/S) Unassigned -> 11q13 Invasive Tumor Cells (G1/S) 1.1593709248207684e-06 0.0 0.6614977577544194 0.0 0.0 0.0003671083100858 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1310113 JAG1 NOTCH2 JAG1-NOTCH2 Myeloid Cells Unassigned Myeloid Cells -> Unassigned 1.156137029336432e-06 0.6303682835571691 0.0 0.0 0.0003788349535045 0.0 0.0 0.0 0.0 0.0 1 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1310157 THBS2 CD36 THBS2-CD36 Luminal-like Amorphous DCIS Cells Unassigned Luminal-like Amorphous DCIS Cells -> Unassigned 1.15099905383215e-06 0.2510234128936706 0.0 0.0 0.0009262556366009 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1310184 COL4A1 CD93 COL4A1-CD93 Mast Cells Unassigned Mast Cells -> Unassigned 1.1494866895768886e-06 0.7766289238087107 0.0 0.0 0.0002970267018348 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1310277 VWF SELP VWF-SELP CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.146659437152153e-06 0.9275752708651288 0.0 0.0 0.000245041593909 0.0 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1310279 VWF LRP1 VWF-LRP1 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.146659437152153e-06 0.9275752708651288 0.0 0.0 0.000245041593909 0.0 0.0 0.0 0.0 0.0 9 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1310283 VWF ITGA9 VWF-ITGA9 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.146659437152153e-06 0.9275752708651288 0.0 0.0 0.000245041593909 0.0 0.0 0.0 0.0 0.0 9 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1310310 THBS2 CD36 THBS2-CD36 Mast Cells Unassigned Mast Cells -> Unassigned 1.145775759418626e-06 0.8581959463413404 0.0 0.0 0.0002636300075004 0.0 0.0 0.0 0.0 0.0 1 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1310329 VWF ITGA9 VWF-ITGA9 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.1430461621162102e-06 0.6332974881236617 0.0 0.0 0.0003521782369754 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1310335 VWF LRP1 VWF-LRP1 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.1430461621162102e-06 0.6332974881236617 0.0 0.0 0.0003521782369754 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1310337 VWF SELP VWF-SELP 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.1430461621162102e-06 0.6332974881236617 0.0 0.0 0.0003521782369754 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1310739 CD48 CD2 CD48-CD2 Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.1181881355162469e-06 0.0 0.7763428264267787 0.0 0.0 0.0002517784065132 0.0 0.0 0.0 0.0 10 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1310757 MMRN2 CLEC14A MMRN2-CLEC14A B Cells Unassigned B Cells -> Unassigned 1.1171127357415051e-06 0.6301823358791634 0.0 0.0 0.0003083910058032 0.0 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1310758 MMRN2 CD93 MMRN2-CD93 B Cells Unassigned B Cells -> Unassigned 1.1171127357415051e-06 0.6301823358791634 0.0 0.0 0.0003083910058032 0.0 0.0 0.0 0.0 0.0 2 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1310883 VWF LRP1 VWF-LRP1 Mast Cells Unassigned Mast Cells -> Unassigned 1.102298245743728e-06 0.8525936146535493 0.0 0.0 0.0002103933337194 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1310886 VWF ITGA9 VWF-ITGA9 Mast Cells Unassigned Mast Cells -> Unassigned 1.102298245743728e-06 0.8525936146535493 0.0 0.0 0.0002103933337194 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1310887 VWF SELP VWF-SELP Mast Cells Unassigned Mast Cells -> Unassigned 1.102298245743728e-06 0.8525936146535493 0.0 0.0 0.0002103933337194 0.0 0.0 0.0 0.0 0.0 1 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1310931 JAG1 NOTCH2 JAG1-NOTCH2 Macrophages Unassigned Macrophages -> Unassigned 1.0960488211014503e-06 0.6303682835571691 0.0 0.0 0.0002750231449378 0.0 0.0 0.0 0.0 0.0 1 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1310964 JAG1 NOTCH2 JAG1-NOTCH2 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.093058364551107e-06 0.6303682835571691 0.0 0.0 0.0002705513462707 0.0 0.0 0.0 0.0 0.0 1 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1311166 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Mast Cells Unassigned -> Mast Cells 1.0771017284479806e-06 0.0 0.8341464445360613 0.0 0.0 0.0001871866311057 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1311171 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Mast Cells Unassigned -> Mast Cells 1.0771017284479806e-06 0.0 0.8341464445360613 0.0 0.0 0.0001871866311057 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1311178 MMRN2 CLEC14A MMRN2-CLEC14A Plasma Cells Unassigned Plasma Cells -> Unassigned 1.076963806790858e-06 0.7205550478301406 0.0 0.0 0.0002165306714062 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1311180 MMRN2 CD93 MMRN2-CD93 Plasma Cells Unassigned Plasma Cells -> Unassigned 1.076963806790858e-06 0.7205550478301406 0.0 0.0 0.0002165306714062 0.0 0.0 0.0 0.0 0.0 1 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1311255 VWF LRP1 VWF-LRP1 B Cells Unassigned B Cells -> Unassigned 1.0699304531914662e-06 0.6332974881236617 0.0 0.0 0.00023686843287 0.0 0.0 0.0 0.0 0.0 2 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1311257 VWF ITGA9 VWF-ITGA9 B Cells Unassigned B Cells -> Unassigned 1.0699304531914662e-06 0.6332974881236617 0.0 0.0 0.00023686843287 0.0 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1311260 VWF SELP VWF-SELP B Cells Unassigned B Cells -> Unassigned 1.0699304531914662e-06 0.6332974881236617 0.0 0.0 0.00023686843287 0.0 0.0 0.0 0.0 0.0 2 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1311288 DLL4 NOTCH4 DLL4-NOTCH4 B Cells Unassigned B Cells -> Unassigned 1.0670728815688268e-06 0.6342079770588467 0.0 0.0 0.0002327631000826 0.0 0.0 0.0 0.0 0.0 2 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1311290 DLL4 NOTCH3 DLL4-NOTCH3 B Cells Unassigned B Cells -> Unassigned 1.0670728815688268e-06 0.6342079770588467 0.0 0.0 0.0002327631000826 0.0 0.0 0.0 0.0 0.0 2 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1311421 JAG1 NOTCH2 JAG1-NOTCH2 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.0557356118399111e-06 0.6303682835571691 0.0 0.0 0.000219642761279 0.0 0.0 0.0 0.0 0.0 9 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1311647 THBS2 CD36 THBS2-CD36 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.0341545883708268e-06 0.6242573126045354 0.0 0.0 0.0001959417442809 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1311650 MMRN2 CLEC14A MMRN2-CLEC14A CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.033945546983713e-06 0.940547666092272 0.0 0.0 0.0001298888146421 0.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1311651 MMRN2 CD93 MMRN2-CD93 CXCL14+ Fibroblasts Unassigned CXCL14+ Fibroblasts -> Unassigned 1.033945546983713e-06 0.940547666092272 0.0 0.0 0.0001298888146421 0.0 0.0 0.0 0.0 0.0 9 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1311685 CXCL12 ITGA4 CXCL12-ITGA4 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.032949339362942e-06 0.6160088550075702 0.0 0.0 0.0001971810371238 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1311693 CXCL12 CXCR4 CXCL12-CXCR4 11q13 Invasive Tumor Cells (G1/S) Unassigned 11q13 Invasive Tumor Cells (G1/S) -> Unassigned 1.032949339362942e-06 0.6160088550075702 0.0 0.0 0.0001971810371238 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1311847 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Apocrine Cells Unassigned -> Apocrine Cells 1.018180282822426e-06 0.0 0.2491545808994955 0.0 0.0 0.0004471667362236 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1311913 VWF SELP VWF-SELP Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.0080018126899383e-06 0.0 0.8819126042133903 0.0 0.0 0.0001189339410417 0.0 0.0 0.0 0.0 10 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1311916 CD34 SELP CD34-SELP Unassigned CXCL14+ Fibroblasts Unassigned -> CXCL14+ Fibroblasts 1.0080018126899383e-06 0.0 0.8819126042133903 0.0 0.0 0.0001189339410417 0.0 0.0 0.0 0.0 10 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1312079 JAG1 NOTCH2 JAG1-NOTCH2 B Cells Unassigned B Cells -> Unassigned 9.927319270767894e-07 0.8630183004227985 0.0 0.0 0.0001109003117737 0.0 0.0 0.0 0.0 0.0 2 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1312096 CD34 SELP CD34-SELP Apocrine Cells Unassigned Apocrine Cells -> Unassigned 9.895154956493255e-07 0.2491449441646273 0.0 0.0 0.0003767662344862 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1312249 VWF LRP1 VWF-LRP1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 9.758965186362665e-07 0.0 0.2550748532138862 0.0 0.0 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1312254 C1QB LRP1 C1QB-LRP1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 9.758965186362665e-07 0.0 0.2550748532138862 0.0 0.0 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1312257 HSPG2 LRP1 HSPG2-LRP1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 9.758965186362665e-07 0.0 0.2550748532138862 0.0 0.0 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1312260 C3 LRP1 C3-LRP1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 9.758965186362665e-07 0.0 0.2550748532138862 0.0 0.0 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1312261 A2M LRP1 A2M-LRP1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 9.758965186362665e-07 0.0 0.2550748532138862 0.0 0.0 0.0003386430177035 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1312472 THBS2 CD36 THBS2-CD36 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 9.358345887446064e-07 0.0 0.2562573700401372 0.0 0.0 0.0002621208738319 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1312542 JAG1 NOTCH2 JAG1-NOTCH2 Mast Cells Unassigned Mast Cells -> Unassigned 9.24476519044028e-07 0.6303682835571691 0.0 0.0 9.902323108165852e-05 0.0 0.0 0.0 0.0 0.0 1 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1312598 CXCL12 ITGA4 CXCL12-ITGA4 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 9.13305236465665e-07 0.255669001367946 0.0 0.0 0.0002269856810233 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1312607 CXCL12 CXCR4 CXCL12-CXCR4 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 9.13305236465665e-07 0.255669001367946 0.0 0.0 0.0002269856810233 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1312783 MMP2 PECAM1 MMP2-PECAM1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 8.896696349826539e-07 0.0 0.2491073778594529 0.0 0.0 0.0001990509171164 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1312785 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 8.896696349826539e-07 0.0 0.2491073778594529 0.0 0.0 0.0001990509171164 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1312842 MMP2 PECAM1 MMP2-PECAM1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 8.770338914632642e-07 0.2491408586098361 0.0 0.0 0.0001826541344284 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1313068 DLL4 NOTCH3 DLL4-NOTCH3 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 8.25244040693086e-07 0.2490567623945399 0.0 0.0 0.000126812416921 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1313069 DLL4 NOTCH4 DLL4-NOTCH4 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 8.25244040693086e-07 0.2490567623945399 0.0 0.0 0.000126812416921 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1313138 VWF SELP VWF-SELP Apocrine Cells Unassigned Apocrine Cells -> Unassigned 8.029294970854323e-07 0.2486570577556728 0.0 0.0 0.0001077515101466 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1313143 VWF ITGA9 VWF-ITGA9 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 8.029294970854323e-07 0.2486570577556728 0.0 0.0 0.0001077515101466 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1313144 VWF LRP1 VWF-LRP1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 8.029294970854323e-07 0.2486570577556728 0.0 0.0 0.0001077515101466 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1313212 MMRN2 CLEC14A MMRN2-CLEC14A Apocrine Cells Unassigned Apocrine Cells -> Unassigned 7.489762069649933e-07 0.250044481781731 0.0 0.0 7.058774627838557e-05 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1313213 MMRN2 CD93 MMRN2-CD93 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 7.489762069649933e-07 0.250044481781731 0.0 0.0 7.058774627838557e-05 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1313268 THBS2 CD36 THBS2-CD36 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 7.136162505622125e-07 0.2510234128936706 0.0 0.0 5.260070730345377e-05 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1313531 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1313610 CD48 CD2 CD48-CD2 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1313668 COL4A1 CD93 COL4A1-CD93 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1313914 MMP2 PECAM1 MMP2-PECAM1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling CAF-endothelial remodeling CAF MMP2 toward endothelial PECAM1 supports a stromal-remodeling interface around vasculature. MMP2 is a classic ECM remodeling enzyme; PECAM1 anchors the receiver identity as endothelial. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1314012 HSPG2 LRP1 HSPG2-LRP1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1314099 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1314216 CCN1 CAV1 CCN1-CAV1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling mechanovascular signaling CCN1-CAV1 suggests a CAF/endothelial mechanovascular or matrix-associated signaling axis. Treat as a topology-supported mechanovascular hypothesis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1314251 THBS2 CD36 THBS2-CD36 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 CAF_ECM_remodeling stromal matrix angiogenesis CAF THBS2 to endothelial CD36 supports matrix-rich stromal angiogenesis biology. THBS/CD36 biology is interpretable in matrix remodeling, angiogenesis, and stromal context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1314322 VWF LRP1 VWF-LRP1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM vascular-stromal matrix/scavenger axis Endothelial VWF toward CAF LRP1 highlights a vascular-to-stromal matrix/scavenger-receptor interface. This is a high-scoring dataset-supported vascular-stromal hypothesis rather than a single canonical pathway claim. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1314466 COL4A2 CD93 COL4A2-CD93 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1314487 CD34 SELP CD34-SELP Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1314810 MMRN2 CD93 MMRN2-CD93 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1314855 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1315135 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1315164 EFNB2 PECAM1 EFNB2-PECAM1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1315217 VWF SELP VWF-SELP Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1315243 MMRN2 CLEC14A MMRN2-CLEC14A Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix tumor endothelial angiogenic complex MMRN2-CLEC14A points to tumor endothelial matrix remodeling and angiogenic vessel state. CD93/CLEC14A/MMRN2 family biology is linked to tumor vasculature, matrix organization, and endothelial angiogenic programs. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1315618 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1315728 VEGFC FLT1 VEGFC-FLT1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1315789 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1315873 VWF ITGA9 VWF-ITGA9 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB vascular adhesion / integrin VWF-ITGA9 extends the VWF vascular adhesion theme within endothelial neighborhoods. Interpret as an integrin-associated vascular adhesion hypothesis supported by endothelial spatial contact. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1316209 C1QB LRP1 C1QB-LRP1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1316229 A2M LRP1 A2M-LRP1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1316291 C3 LRP1 C3-LRP1 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger complement-ECM/scavenger receptor C3-LRP1 supports complement/scavenger-receptor biology in CAF-rich tissue neighborhoods. Dataset-supported complement/scavenger hypothesis; interpret with cell-type specificity checks. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1316588 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Unassigned Unassigned -> Unassigned 2.1544346936226055e-07 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1317686 JAG1 NOTCH2 JAG1-NOTCH2 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 1.0115475262135962e-07 0.0 0.0 0.0 0.0 0.0107131540183669 0.0 0.0 0.0 0.0 0 1.0 tumor_Notch tumor Notch signaling Tumor-intrinsic JAG1-NOTCH2 suggests a Notch signaling state within 11q13 invasive tumor cells. JAG1/Notch signaling is broadly linked to cancer cell state, angiogenesis, stemness, EMT, and therapy resistance. jag1_notch The Notch ligand Jagged1 as a target for anti-tumor therapy: https://pmc.ncbi.nlm.nih.gov/articles/PMC4174884/ True +1317830 CLEC2D KLRB1 CLEC2D-KLRB1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 9.937233795940333e-08 0.0 0.0 0.0 0.0096292529477205 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1318498 DLL1 NOTCH3 DLL1-NOTCH3 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 8.985764772464224e-08 0.0 0.0 0.0 0.0 0.0052641644527029 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch DLL1-NOTCH3 provides another endothelial-to-pericyte Notch axis. Treat as supportive Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1318499 DLL4 NOTCH3 DLL4-NOTCH3 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 8.985764772464224e-08 0.0 0.0 0.0 0.0 0.0052641644527029 0.0 0.0 0.0 0.0 0 1.0 Notch_pericyte endothelial-pericyte Notch Endothelial DLL4 to pericyte NOTCH3 supports vascular stabilization and pericyte-endothelial Notch biology. Notch1/Notch3 and DLL4-linked endothelial-pericyte signaling are reported in vascular stabilization contexts. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ True +1318668 EFNB2 PECAM1 EFNB2-PECAM1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 8.698239013083643e-08 0.0 0.0 0.0 0.0043309883979474 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_identity endothelial identity / vascular adhesion Endothelial EFNB2-PECAM1 supports a vascular identity and endothelial adhesion/state axis. Both genes mark vascular/endothelial biology; interpret as endothelial organization rather than secreted paracrine signaling. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1318688 CLEC2D KLRB1 CLEC2D-KLRB1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 8.6724344539716e-08 0.0 0.0 0.0 0.0 0.0042544667714474 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T/NK immune-regulatory interaction CLEC2D-KLRB1 suggests a T/NK immune-regulatory neighborhood. Useful as an immune hypothesis; less central than CD48-CD2 or CXCL12-CXCR4. immune_checkpoint KLRB1/CLEC2D is interpreted as T/NK immune-regulatory biology; use as an immune-cell hypothesis. False +1318999 VEGFC FLT1 VEGFC-FLT1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 8.175758521812083e-08 0.0 0.0 0.0 0.0029865299894135 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1319068 COL4A2 CD93 COL4A2-CD93 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 7.921444194020393e-08 0.0 0.0 0.0 0.0024707251961819 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1319075 CXCL12 CXCR4 CXCL12-CXCR4 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 7.912972898441797e-08 0.0 0.0 0.0 0.0 0.0024549141020602 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment canonical CAF-immune chemokine axis CAF CXCL12 to T-cell CXCR4 recovers a canonical stromal chemokine immune-recruitment axis. CXCL12/CXCR4 is a well-studied cancer-stroma chemokine pathway with immune and tumor-microenvironment relevance. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ True +1319087 VEGFC FLT1 VEGFC-FLT1 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 7.827469922432873e-08 0.0 0.0 0.0 0.0 0.00229999322473 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_growth_factor VEGF/angiogenesis VEGFC-FLT1 supports a vascular growth-factor/angiogenesis interpretation. Canonical VEGF-family ligand/receptor biology makes this a straightforward angiogenic axis. vegf Reactome VEGFA-VEGFR2 pathway and VEGF-family angiogenesis context: https://reactome.org/content/detail/R-HSA-4420097 True +1319208 DLL4 NOTCH4 DLL4-NOTCH4 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 7.525435077572576e-08 0.0 0.0 0.0 0.0 0.0018162987722844 0.0 0.0 0.0 0.0 0 1.0 Notch_vascular endothelial Notch/angiogenesis DLL4-NOTCH4 extends the endothelial Notch angiogenesis module. Treat as supportive endothelial Notch biology and partially redundant with DLL4-NOTCH3. notch_pericyte Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature: https://pubmed.ncbi.nlm.nih.gov/34878922/ False +1319270 CD48 CD2 CD48-CD2 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 7.213465155165585e-08 0.0 0.0 0.0 0.001408836344877 0.0 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1319356 C1QB LRP1 C1QB-LRP1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 6.834034040215174e-08 0.0 0.0 0.0 0.0010187287506117 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger macrophage-CAF complement/scavenger axis Macrophage C1QB to CAF LRP1 suggests complement/scavenger biology in macrophage-stromal niches. Useful as a myeloid-stromal hypothesis rather than a vascular headline axis. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1319361 A2M LRP1 A2M-LRP1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 6.82792119468954e-08 0.0 0.0 0.0 0.0010132735682542 0.0 0.0 0.0 0.0 0.0 0 1.0 complement_scavenger protease inhibitor/scavenger receptor A2M-LRP1 highlights protease-inhibitor/scavenger-receptor signaling around vascular-stromal niches. LRP1 is a plausible receptor for protease-inhibitor/scavenger biology. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. False +1319438 VWF SELP VWF-SELP Unassigned Apocrine Cells Unassigned -> Apocrine Cells 6.325952948742115e-08 0.0 0.0 0.0 0.0 0.0006408390492498 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB WPB / endothelial activation Endothelial VWF-SELP suggests a Weibel-Palade body/P-selectin-like vascular adhesion state. VWF and P-selectin are core endothelial Weibel-Palade body cargos linked to hemostasis, inflammation, and leukocyte rolling. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ True +1319441 CD34 SELP CD34-SELP Unassigned Apocrine Cells Unassigned -> Apocrine Cells 6.325952948742115e-08 0.0 0.0 0.0 0.0 0.0006408390492498 0.0 0.0 0.0 0.0 0 1.0 vascular_WPB endothelial adhesion CD34-SELP supports an endothelial adhesion program aligned with the VWF-SELP top hit. SELP/P-selectin biology links this to endothelial activation and adhesion. wpb Weibel-Palade Bodies, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK535353/ False +1319464 CXCL12 ITGA4 CXCL12-ITGA4 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 6.285697233910998e-08 0.0 0.0 0.0 0.0 0.0006167564619166 0.0 0.0 0.0 0.0 0 1.0 immune_recruitment CAF-T cell immune recruitment/adhesion CAF CXCL12 to T-cell ITGA4 suggests chemokine-linked immune adhesion/recruitment. Interpret as a CXCL12-associated immune/stromal neighborhood, not as a replacement for CXCL12-CXCR4. cxcl12 Chemokine signaling in cancer-stroma communications: https://pmc.ncbi.nlm.nih.gov/articles/PMC8222467/ False +1319488 MMRN2 CD93 MMRN2-CD93 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 6.174979655635327e-08 0.0 0.0 0.0 0.0 0.0005543771898401 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix CD93-MMRN2 angiogenesis MMRN2-CD93 is a direct interpretable tumor-endothelial matrix/angiogenesis axis. CD93-MMRN2 signaling has reported roles in beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1319491 COL4A1 CD93 COL4A1-CD93 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 6.174979655635327e-08 0.0 0.0 0.0 0.0 0.0005543771898401 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False +1319497 COL4A2 CD93 COL4A2-CD93 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 6.174979655635327e-08 0.0 0.0 0.0 0.0 0.0005543771898401 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A2-CD93 links endothelial basement membrane signal with angiogenic endothelial receptor state. CD93 is implicated in endothelial matrix organization and tumor angiogenesis. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ True +1319507 HSPG2 LRP1 HSPG2-LRP1 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 6.04647568241694e-08 0.0 0.0 0.0 0.00048865795825 0.0 0.0 0.0 0.0 0.0 0 1.0 vascular_stromal_ECM basement membrane / ECM receptor Endothelial HSPG2 to CAF LRP1 suggests basement-membrane-rich vascular-stromal remodeling. LRP1 frequently acts as a scavenger/ECM-associated receptor; here the strongest support is spatial WTA context. ecm_lrp1 Interpreted as ECM/scavenger-receptor biology in the pyXenium WTA context; use as dataset-supported hypothesis. True +1319527 CD48 CD2 CD48-CD2 Unassigned Apocrine Cells Unassigned -> Apocrine Cells 5.8406524407058685e-08 0.0 0.0 0.0 0.0 0.0003969695918337 0.0 0.0 0.0 0.0 0 1.0 T_cell_signaling T-cell adhesion/co-stimulation T-cell CD48-CD2 indicates lymphocyte-local adhesion/co-stimulation biology. CD48-CD2 has experimental support in T-cell adhesion and activation contexts. cd48_cd2 Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48: https://pubmed.ncbi.nlm.nih.gov/9862369/ True +1319561 COL4A1 CD93 COL4A1-CD93 Apocrine Cells Unassigned Apocrine Cells -> Unassigned 5.4373230258817045e-08 0.0 0.0 0.0 0.0002584008880758 0.0 0.0 0.0 0.0 0.0 0 1.0 angiogenesis_matrix basement membrane angiogenesis COL4A1-CD93 is another basement-membrane/CD93 vascular angiogenesis axis. Kept in appendix/main table but treated as partially redundant with COL4A2-CD93. cd93_mmrn2 CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis: https://pmc.ncbi.nlm.nih.gov/articles/PMC6063507/ False diff --git a/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_summary.json b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_summary.json new file mode 100644 index 0000000..2cbcbce --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_classic_axes/tables/topolink_cci_classic_axes_summary.json @@ -0,0 +1,34 @@ +{ + "input": "D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\pdc_collected\\pdc_20260426_1327\\runs\\full_common\\pyxenium\\pyxenium_scores.tsv", + "input_rows": 1319600, + "headline_rows": 15, + "all_classic_rows": 10000, + "caveat_rows": 80, + "headline_top": [ + { + "lr_pair": "VWF-SELP", + "sender_receiver": "Endothelial Cells -> Endothelial Cells", + "CCI_score": 0.7912892368005828 + }, + { + "lr_pair": "VWF-LRP1", + "sender_receiver": "Endothelial Cells -> CAFs, DCIS Associated", + "CCI_score": 0.7479758913021439 + }, + { + "lr_pair": "EFNB2-PECAM1", + "sender_receiver": "Endothelial Cells -> Endothelial Cells", + "CCI_score": 0.7469197326713805 + }, + { + "lr_pair": "MMRN2-CLEC14A", + "sender_receiver": "Endothelial Cells -> Endothelial Cells", + "CCI_score": 0.7322091602540813 + }, + { + "lr_pair": "HSPG2-LRP1", + "sender_receiver": "Endothelial Cells -> CAFs, DCIS Associated", + "CCI_score": 0.7279607350660221 + } + ] +} \ No newline at end of file diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/README.md b/benchmarking/cci_2026_atera/topolink_cci_short_communication/README.md new file mode 100644 index 0000000..69e5ce7 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/README.md @@ -0,0 +1,29 @@ +# TopoLink-CCI Nature Methods Brief Communication Package + +This folder contains a draft manuscript package for presenting **TopoLink-CCI** as a Nature Methods Brief Communication. + +## Contents + +- `manuscript/topolink_cci_brief_communication.md`: title, abstract, four-paragraph main text draft, figure legends and claims. +- `manuscript/online_methods.md`: reproducible method details for the Online Methods section. +- `manuscript/supplementary_information_outline.md`: planned Supplementary Notes, Figures, Tables and Data. +- `manuscript/supplementary_data_manifest.tsv`: source paths for supplementary data and software artifacts. +- `manuscript/presubmission_inquiry.md`: concise Nature Methods presubmission inquiry draft. +- `scripts/make_topolink_cci_nature_brief_figures.py`: reproducible figure-generation script. +- `figures/`: generated Figure 1 and Figure 2 drafts in PNG, PDF and SVG formats. + +## Regenerate Figures + +From the repository root: + +```powershell +python benchmarking\cci_2026_atera\topolink_cci_short_communication\scripts\make_topolink_cci_nature_brief_figures.py +``` + +## Naming + +The formal method name is **TopoLink-CCI**. The current benchmark uses TopoLink-CCI in **cell-cell interaction-resource mode**, so historical `TopoLink-CCI` wording should be treated as a mode name rather than the manuscript-level method name. + +## Interpretation Guardrail + +TopoLink-CCI prioritizes computationally supported spatial molecular interaction hypotheses. 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Schematic panel; source data records graphical elements. +fig1b topolink_score_formula TopoLink-CCI score formula D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig1b_topolink_score_formula.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig1b_topolink_score_formula.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig1b_topolink_score_formula.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig1b_topolink_score_formula.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig1b_topolink_score_formula.json 180.0 65.0 Arial 42 none 15 7 pdffonts_not_available False 6 {} The discovery score is a prior-weighted geometric mean of six diagnostic components. Schematic formula uses editable text rather than math outlines. +fig1c local_contact_model Local contact model D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig1c_local_contact_model.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig1c_local_contact_model.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig1c_local_contact_model.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig1c_local_contact_model.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig1c_local_contact_model.json 85.0 65.0 Arial 42 none 3 9 pdffonts_not_available False 12 {} Local contact links candidate molecular axes to the actual cell-cell neighbor graph. Schematic panel; source data records nodes and edges. +fig1d validation_gate_map Validation gate map D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig1d_validation_gate_map.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig1d_validation_gate_map.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig1d_validation_gate_map.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig1d_validation_gate_map.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig1d_validation_gate_map.json 180.0 65.0 Arial 42 none 22 25 pdffonts_not_available False 6 {} TopoLink-CCI reports candidates with controls inspired by established CCC methods. Schematic mapping, not a claim of identical software reimplementation. +fig1e evidence_matrix Evidence matrix D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig1e_evidence_matrix.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig1e_evidence_matrix.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig1e_evidence_matrix.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig1e_evidence_matrix.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig1e_evidence_matrix.json 180.0 65.0 Arial 42 none 18 24 pdffonts_not_available False 63 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\pdc_validation_v2_collected\\topolink_cci_validation_v2\\tables\\topolink_cci_validation_v2_evidence.tsv"": ""d87a16edfce1c50e""}" Seven representative TopoLink-CCI axes have strong computational support. Orange marks are axis-specific weak evidence layers, not artifact-risk calls. +fig1f false_positive_controls_quantitative Quantitative false-positive controls D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig1f_false_positive_controls_quantitative.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig1f_false_positive_controls_quantitative.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig1f_false_positive_controls_quantitative.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig1f_false_positive_controls_quantitative.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig1f_false_positive_controls_quantitative.json 180.0 65.0 Arial 42 none 13 33 pdffonts_not_available False 28 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\pdc_validation_v2_collected\\topolink_cci_validation_v2\\tables\\topolink_cci_validation_v2_evidence.tsv"": ""d87a16edfce1c50e""}" Representative axes pass multiple quantitative controls, not just the TopoLink-CCI score. Bubble sizes use transformed metrics; raw values are in source data. +fig2a whole_dataset_rank_landscape Whole-dataset score landscape D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2a_whole_dataset_rank_landscape.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2a_whole_dataset_rank_landscape.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2a_whole_dataset_rank_landscape.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2a_whole_dataset_rank_landscape.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2a_whole_dataset_rank_landscape.json 180.0 65.0 Arial 42 none 19 21 pdffonts_not_available False 126 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\pdc_collected\\pdc_20260426_1327\\runs\\full_common\\pyxenium\\pyxenium_scores.tsv"": ""7bb7f9fcf3d2c589"", ""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\pdc_validation_v2_collected\\topolink_cci_validation_v2\\tables\\topolink_cci_validation_v2_evidence.tsv"": ""d87a16edfce1c50e""}" TopoLink-CCI ranks 1,319,600 whole-dataset candidate axes and highlights validated discoveries. Histogram bins are source data; highlighted lines mark seven representative axes. +fig2b top_interpretable_axes Top interpretable axes D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2b_top_interpretable_axes.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2b_top_interpretable_axes.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2b_top_interpretable_axes.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2b_top_interpretable_axes.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2b_top_interpretable_axes.json 85.0 65.0 Arial 42 none 26 22 pdffonts_not_available False 7 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\pdc_validation_v2_collected\\topolink_cci_validation_v2\\tables\\topolink_cci_validation_v2_evidence.tsv"": ""d87a16edfce1c50e""}" High-scoring axes span vascular, immune, stromal, Notch and tumor-intrinsic biology. +fig2c vwf_selp_component_decomposition VWF-SELP component decomposition D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2c_vwf_selp_component_decomposition.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2c_vwf_selp_component_decomposition.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2c_vwf_selp_component_decomposition.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2c_vwf_selp_component_decomposition.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2c_vwf_selp_component_decomposition.json 85.0 65.0 Arial 42 none 17 19 pdffonts_not_available False 6 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\vwf_selp_deep_dive\\tables\\component_decomposition.tsv"": ""6f0b1eacf87f74cf""}" The lead endothelial axis combines topology, expression and local contact support. +fig2d vwf_selp_rank_sensitivity VWF-SELP rank sensitivity D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2d_vwf_selp_rank_sensitivity.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2d_vwf_selp_rank_sensitivity.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2d_vwf_selp_rank_sensitivity.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2d_vwf_selp_rank_sensitivity.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2d_vwf_selp_rank_sensitivity.json 85.0 65.0 Arial 42 none 19 14 pdffonts_not_available False 10 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\vwf_selp_deep_dive\\tables\\rank_sensitivity.tsv"": ""efddedb339329d7b""}" Component perturbations test whether the top axis is driven by one isolated term. +fig2e expression_specificity_dotplot Expression specificity dotplot D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2e_expression_specificity_dotplot.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2e_expression_specificity_dotplot.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2e_expression_specificity_dotplot.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2e_expression_specificity_dotplot.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2e_expression_specificity_dotplot.json 180.0 65.0 Arial 42 none 42 302 pdffonts_not_available False 260 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\vwf_selp_deep_dive\\tables\\expression_specificity_full_wta.tsv"": ""22d656b1269d11c5""}" VWF-SELP interpretation is supported by endothelial marker specificity and contamination controls. RNA expression specificity does not prove protein localization. +fig2f vwf_selp_spatial_hotspots VWF-SELP spatial hotspots D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2f_vwf_selp_spatial_hotspots.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2f_vwf_selp_spatial_hotspots.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2f_vwf_selp_spatial_hotspots.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2f_vwf_selp_spatial_hotspots.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2f_vwf_selp_spatial_hotspots.json 85.0 85.0 Arial 42 none 24 10 pdffonts_not_available True 170490 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\pdc_collected\\pdc_20260426_1327\\runs\\full_common\\pyxenium\\input_cache\\adata_full_from_sparse_bundle.h5ad"": ""7a0756a5bd491109"", ""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\vwf_selp_deep_dive\\tables\\vwf_selp_hotspot_endothelial_cells.tsv"": ""007e51168b7044fb""}" VWF-SELP hotspots localize to a subset of endothelial neighborhoods. Dense background cells are rasterized to keep Illustrator files usable. +fig2g hotspot_neighborhood_context Hotspot neighborhood context D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2g_hotspot_neighborhood_context.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2g_hotspot_neighborhood_context.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2g_hotspot_neighborhood_context.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2g_hotspot_neighborhood_context.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2g_hotspot_neighborhood_context.json 85.0 65.0 Arial 42 none 24 27 pdffonts_not_available False 12 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\vwf_selp_deep_dive\\tables\\hotspot_neighbor_context.tsv"": ""5b259e3b08beccd5""}" Endothelial VWF-SELP hotspots can be interpreted through their neighboring cell ecology. +fig2h pathway_context Pathway context D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2h_pathway_context.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2h_pathway_context.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2h_pathway_context.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2h_pathway_context.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2h_pathway_context.json 85.0 65.0 Arial 42 none 13 14 pdffonts_not_available False 3 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\vwf_selp_deep_dive\\tables\\vwf_selp_pathway_correlations.tsv"": ""36dbc5ebc77852e2""}" VWF-SELP hotspots align with vascular identity and thromboinflammatory pathway panels. Pathway panels are RNA-level summaries. +fig2i contour_ecology_context Contour ecology context D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2i_contour_ecology_context.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2i_contour_ecology_context.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2i_contour_ecology_context.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2i_contour_ecology_context.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2i_contour_ecology_context.json 85.0 65.0 Arial 42 none 23 17 pdffonts_not_available False 6 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\vwf_selp_deep_dive\\tables\\contour_hypothesis_ranking.tsv"": ""e39cccaddcc1bdd3""}" Vascular interaction axes can be interpreted in the broader contour and tissue-ecology context. +fig2j cross_method_consensus Cross-method consensus D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\pdf\fig2j_cross_method_consensus.pdf D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\svg\fig2j_cross_method_consensus.svg D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\png\fig2j_cross_method_consensus.png D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\source_data\fig2j_cross_method_consensus.tsv D:\GitHub\pyXenium\benchmarking\cci_2026_atera\topolink_cci_short_communication\figures\panels\metadata\fig2j_cross_method_consensus.json 180.0 65.0 Arial 42 none 14 19 pdffonts_not_available False 35 "{""D:\\GitHub\\pyXenium\\benchmarking\\cci_2026_atera\\pdc_validation_v2_collected\\topolink_cci_validation_v2\\tables\\cross_method_support_detail.tsv"": ""5695b36937c57202""}" TopoLink-CCI discoveries are triangulated against independent method outputs. 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z!$x}w`rKltPBX30XU}j#0jo68_x%}xNgO_Shv#%2UiA(bt7_DROR*Ih=?~Qn_#h_v z?M#Gm!^OC7u%+1%LW%a*AY`=L3f_ihblTR?C3Im5FIdCJCEf^MD(Y+k?U8>x{n=TR zvO~qu1P%h}Xo#i!>Tn`bj2Q<UQEWr-LmymbDRlV85yKOy zII}xg!BB2b4JrX&S2ZT<3zKv@of3{^l!b3Q79NE5bOUx1rT~OURoWO>oo3~e)sSjB zp3~pZg9SYA(V#n+F;l}Osf?@I1&t~yt+POJ~(DO{}?`{Bl+-k6oy(V7( literal 0 HcmV?d00001 diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1a_problem_schematic.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1a_problem_schematic.tsv new file mode 100644 index 0000000..45cee79 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1a_problem_schematic.tsv @@ -0,0 +1,5 @@ +element x y label category value +box 0.17 0.67 expression-only candidate false_positive_source 1 +box 0.48 0.67 database membership false_positive_source 1 +box 0.79 0.67 spatial proximity false_positive_source 1 +box 0.5 0.23 TopoLink-CCI combined evidence solution 1 diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1b_topolink_score_formula.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1b_topolink_score_formula.tsv new file mode 100644 index 0000000..bec1a09 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1b_topolink_score_formula.tsv @@ -0,0 +1,7 @@ +element x y label category description value +component 0.185 0.53 sender anchor score_component ligand fits sender topology 1 +component 0.495 0.53 receiver anchor score_component receptor fits receiver topology 2 +component 0.805 0.53 structure bridge score_component sender-receiver tissue relation 3 +component 0.185 0.26 sender expression score_component ligand expressed in sender 4 +component 0.495 0.26 receiver expression score_component receptor expressed in receiver 5 +component 0.805 0.26 local contact score_component neighbor edges support interaction 6 diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1c_local_contact_model.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1c_local_contact_model.tsv new file mode 100644 index 0000000..c7c156b --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1c_local_contact_model.tsv @@ -0,0 +1,13 @@ +element x y label category value +node 0.25 0.68 sender_1 sender 1.0 +node 0.2 0.48 sender_2 sender 1.0 +node 0.32 0.32 sender_3 sender 1.0 +node 0.68 0.7 receiver_1 receiver 1.0 +node 0.76 0.5 receiver_2 receiver 1.0 +node 0.62 0.34 receiver_3 receiver 1.0 +edge 0.465 0.69 edge_1 neighbor_edge 0.9 +edge 0.505 0.5900000000000001 edge_2 neighbor_edge 0.5 +edge 0.48 0.49 edge_3 neighbor_edge 0.7 +edge 0.47 0.33 edge_4 neighbor_edge 0.8 +edge 0.41000000000000003 0.41000000000000003 edge_5 neighbor_edge 0.2 +formula 0.5 0.14 local contact support summary 1.0 diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1d_validation_gate_map.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1d_validation_gate_map.tsv new file mode 100644 index 0000000..5f6fe8c --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1d_validation_gate_map.tsv @@ -0,0 +1,7 @@ +element x y label category value +gate 0.10500000000000001 0.3 cell-label permutation CellPhoneDB/ Squidpy 1 +gate 0.26 0.3 group specificity CellChat 2 +gate 0.415 0.3 spatial null + matched genes stLearn/ SpatialDM 3 +gate 0.5700000000000001 0.3 receiver target support NicheNet 4 +gate 0.7250000000000001 0.3 cross-method consensus LIANA 5 +gate 0.8800000000000001 0.3 ablation + bootstrap pyXenium 6 diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1e_evidence_matrix.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1e_evidence_matrix.tsv new file mode 100644 index 0000000..b3ba3d5 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1e_evidence_matrix.tsv @@ -0,0 +1,64 @@ +x y value category label +expression VWF-SELP 1 pass VWF-SELP:expression +label perm. VWF-SELP 1 pass VWF-SELP:label perm. +spatial null VWF-SELP 1 pass VWF-SELP:spatial null +matched genes VWF-SELP 1 pass VWF-SELP:matched genes +downstream VWF-SELP 1 pass VWF-SELP:downstream +received signal VWF-SELP 1 pass VWF-SELP:received signal +cross method VWF-SELP 1 pass VWF-SELP:cross method +ablation VWF-SELP 0 weak VWF-SELP:ablation +bootstrap VWF-SELP 1 pass VWF-SELP:bootstrap +expression VWF-LRP1 1 pass VWF-LRP1:expression +label perm. VWF-LRP1 1 pass VWF-LRP1:label perm. +spatial null VWF-LRP1 1 pass VWF-LRP1:spatial null +matched genes VWF-LRP1 1 pass VWF-LRP1:matched genes +downstream VWF-LRP1 1 pass VWF-LRP1:downstream +received signal VWF-LRP1 1 pass VWF-LRP1:received signal +cross method VWF-LRP1 1 pass VWF-LRP1:cross method +ablation VWF-LRP1 0 weak VWF-LRP1:ablation +bootstrap VWF-LRP1 1 pass VWF-LRP1:bootstrap +expression MMRN2-CD93 1 pass MMRN2-CD93:expression +label perm. MMRN2-CD93 1 pass MMRN2-CD93:label perm. +spatial null MMRN2-CD93 1 pass MMRN2-CD93:spatial null +matched genes MMRN2-CD93 1 pass MMRN2-CD93:matched genes +downstream MMRN2-CD93 1 pass MMRN2-CD93:downstream +received signal MMRN2-CD93 1 pass MMRN2-CD93:received signal +cross method MMRN2-CD93 1 pass MMRN2-CD93:cross method +ablation MMRN2-CD93 0 weak MMRN2-CD93:ablation +bootstrap MMRN2-CD93 1 pass MMRN2-CD93:bootstrap +expression CD48-CD2 1 pass CD48-CD2:expression +label perm. CD48-CD2 1 pass CD48-CD2:label perm. +spatial null CD48-CD2 1 pass CD48-CD2:spatial null +matched genes CD48-CD2 1 pass CD48-CD2:matched genes +downstream CD48-CD2 1 pass CD48-CD2:downstream +received signal CD48-CD2 1 pass CD48-CD2:received signal +cross method CD48-CD2 1 pass CD48-CD2:cross method +ablation CD48-CD2 0 weak CD48-CD2:ablation +bootstrap CD48-CD2 1 pass CD48-CD2:bootstrap +expression DLL4-NOTCH3 1 pass DLL4-NOTCH3:expression +label perm. DLL4-NOTCH3 1 pass DLL4-NOTCH3:label perm. +spatial null DLL4-NOTCH3 1 pass DLL4-NOTCH3:spatial null +matched genes DLL4-NOTCH3 1 pass DLL4-NOTCH3:matched genes +downstream DLL4-NOTCH3 1 pass DLL4-NOTCH3:downstream +received signal DLL4-NOTCH3 1 pass DLL4-NOTCH3:received signal +cross method DLL4-NOTCH3 1 pass DLL4-NOTCH3:cross method +ablation DLL4-NOTCH3 0 weak DLL4-NOTCH3:ablation +bootstrap DLL4-NOTCH3 1 pass DLL4-NOTCH3:bootstrap +expression CXCL12-CXCR4 1 pass CXCL12-CXCR4:expression +label perm. CXCL12-CXCR4 1 pass CXCL12-CXCR4:label perm. +spatial null CXCL12-CXCR4 0 weak CXCL12-CXCR4:spatial null +matched genes CXCL12-CXCR4 1 pass CXCL12-CXCR4:matched genes +downstream CXCL12-CXCR4 1 pass CXCL12-CXCR4:downstream +received signal CXCL12-CXCR4 1 pass CXCL12-CXCR4:received signal +cross method CXCL12-CXCR4 1 pass CXCL12-CXCR4:cross method +ablation CXCL12-CXCR4 0 weak CXCL12-CXCR4:ablation +bootstrap CXCL12-CXCR4 1 pass CXCL12-CXCR4:bootstrap +expression JAG1-NOTCH2 1 pass JAG1-NOTCH2:expression +label perm. JAG1-NOTCH2 1 pass JAG1-NOTCH2:label perm. +spatial null JAG1-NOTCH2 1 pass JAG1-NOTCH2:spatial null +matched genes JAG1-NOTCH2 0 weak JAG1-NOTCH2:matched genes +downstream JAG1-NOTCH2 0 weak JAG1-NOTCH2:downstream +received signal JAG1-NOTCH2 1 pass JAG1-NOTCH2:received signal +cross method JAG1-NOTCH2 1 pass JAG1-NOTCH2:cross method +ablation JAG1-NOTCH2 0 weak JAG1-NOTCH2:ablation +bootstrap JAG1-NOTCH2 1 pass JAG1-NOTCH2:bootstrap diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1f_false_positive_controls_quantitative.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1f_false_positive_controls_quantitative.tsv new file mode 100644 index 0000000..f2b1210 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig1f_false_positive_controls_quantitative.tsv @@ -0,0 +1,29 @@ +x y value raw_value category label +label perm. FDR VWF-SELP 2.6998377258672535 0.0019960079840319 -log10 VWF-SELP +spatial null FDR VWF-SELP 2.3324384599156125 0.0046511627906976 -log10 VWF-SELP +matched gene z VWF-SELP 6.674917611699146 6.674917611699146 z VWF-SELP +downstream FDR VWF-SELP 1.5656791933629541 0.0271844660194174 -log10 VWF-SELP +label perm. FDR VWF-LRP1 2.6998377258672535 0.0019960079840319 -log10 VWF-LRP1 +spatial null FDR VWF-LRP1 2.3324384599156125 0.0046511627906976 -log10 VWF-LRP1 +matched gene z VWF-LRP1 11.234674798948532 11.234674798948532 z VWF-LRP1 +downstream FDR VWF-LRP1 1.5356299114333811 0.0291319857312722 -log10 VWF-LRP1 +label perm. FDR MMRN2-CD93 2.6998377258672535 0.0019960079840319 -log10 MMRN2-CD93 +spatial null FDR MMRN2-CD93 2.3324384599156125 0.0046511627906976 -log10 MMRN2-CD93 +matched gene z MMRN2-CD93 6.198278570208171 6.198278570208171 z MMRN2-CD93 +downstream FDR MMRN2-CD93 2.0796979557836566 0.0083234244946492 -log10 MMRN2-CD93 +label perm. FDR CD48-CD2 2.6998377258672535 0.0019960079840319 -log10 CD48-CD2 +spatial null FDR CD48-CD2 1.934498451243571 0.0116279069767441 -log10 CD48-CD2 +matched gene z CD48-CD2 9.860708047779738 9.860708047779738 z CD48-CD2 +downstream FDR CD48-CD2 2.0796979557836566 0.0083234244946492 -log10 CD48-CD2 +label perm. FDR DLL4-NOTCH3 2.6998377258672535 0.0019960079840319 -log10 DLL4-NOTCH3 +spatial null FDR DLL4-NOTCH3 2.3324384599156125 0.0046511627906976 -log10 DLL4-NOTCH3 +matched gene z DLL4-NOTCH3 8.301941713984622 8.301941713984622 z DLL4-NOTCH3 +downstream FDR DLL4-NOTCH3 1.593557303304013 0.0254942767950052 -log10 DLL4-NOTCH3 +label perm. FDR CXCL12-CXCR4 2.6998377258672535 0.0019960079840319 -log10 CXCL12-CXCR4 +spatial null FDR CXCL12-CXCR4 0.2355284469075489 0.5813953488372093 -log10 CXCL12-CXCR4 +matched gene z CXCL12-CXCR4 11.218977606863426 11.218977606863426 z CXCL12-CXCR4 +downstream FDR CXCL12-CXCR4 1.593557303304013 0.0254942767950052 -log10 CXCL12-CXCR4 +label perm. FDR JAG1-NOTCH2 2.6998377258672535 0.0019960079840319 -log10 JAG1-NOTCH2 +spatial null FDR JAG1-NOTCH2 2.3324384599156125 0.0046511627906976 -log10 JAG1-NOTCH2 +matched gene z JAG1-NOTCH2 0.3126368933035661 0.3126368933035661 z JAG1-NOTCH2 +downstream FDR JAG1-NOTCH2 0.21637509566319943 0.6076099881093936 -log10 JAG1-NOTCH2 diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2a_whole_dataset_rank_landscape.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2a_whole_dataset_rank_landscape.tsv new file mode 100644 index 0000000..79cb18d --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2a_whole_dataset_rank_landscape.tsv @@ -0,0 +1,127 @@ +x y value category label +0.0033247446924394236 356987.0 356987 histogram CCI_score_bin +0.009974234077318272 517171.0 517171 histogram CCI_score_bin +0.01662372346219712 272711.0 272711 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CCI_score_bin +0.628376746871051 7.0 7 histogram CCI_score_bin +0.63502623625593 6.0 6 histogram CCI_score_bin +0.6416757256408088 5.0 5 histogram CCI_score_bin +0.6483252150256875 2.0 2 histogram CCI_score_bin +0.6549747044105665 2.0 2 histogram CCI_score_bin +0.6616241937954452 4.0 4 histogram CCI_score_bin +0.6682736831803242 3.0 3 histogram CCI_score_bin +0.674923172565203 5.0 5 histogram CCI_score_bin +0.6815726619500819 2.0 2 histogram CCI_score_bin +0.6882221513349607 2.0 2 histogram CCI_score_bin +0.6948716407198396 2.0 2 histogram CCI_score_bin +0.7015211301047184 0.0 0 histogram CCI_score_bin +0.7081706194895971 3.0 3 histogram CCI_score_bin +0.7148201088744761 2.0 2 histogram CCI_score_bin +0.7214695982593549 0.0 0 histogram CCI_score_bin +0.7281190876442338 1.0 1 histogram CCI_score_bin +0.7347685770291126 1.0 1 histogram CCI_score_bin +0.7414180664139915 2.0 2 histogram CCI_score_bin +0.7480675557988703 2.0 2 histogram CCI_score_bin +0.7547170451837493 0.0 0 histogram CCI_score_bin +0.761366534568628 0.0 0 histogram CCI_score_bin +0.7680160239535068 0.0 0 histogram CCI_score_bin +0.7746655133383857 0.0 0 histogram CCI_score_bin +0.7813150027232645 0.0 0 histogram CCI_score_bin +0.7879644921081435 1.0 1 histogram CCI_score_bin +0.7912892368005828 1 vascular VWF-SELP +0.7479758913021439 2 vascular VWF-LRP1 +0.7107166026857937 10 vascular MMRN2-CD93 +0.6849877065459009 16 immune CD48-CD2 +0.6695148471220083 24 notch DLL4-NOTCH3 +0.6616803690861207 28 stromal CXCL12-CXCR4 +0.6339181063246662 45 tumor JAG1-NOTCH2 diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2b_top_interpretable_axes.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2b_top_interpretable_axes.tsv new file mode 100644 index 0000000..c7aeeea --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2b_top_interpretable_axes.tsv @@ -0,0 +1,8 @@ +pair sender receiver x value biology_label theme y category label +JAG1-NOTCH2 11q13 Invasive Tumor Cells 11q13 Invasive Tumor Cells 0.6339181063246662 45 tumor-intrinsic Notch signaling tumor JAG1-NOTCH2 tumor JAG1-NOTCH2 +CXCL12-CXCR4 CAFs, DCIS Associated T Lymphocytes 0.6616803690861207 28 CAF-immune chemokine recruitment stromal CXCL12-CXCR4 stromal CXCL12-CXCR4 +DLL4-NOTCH3 Endothelial Cells Pericytes 0.6695148471220083 24 endothelial-pericyte Notch notch DLL4-NOTCH3 notch DLL4-NOTCH3 +CD48-CD2 T Lymphocytes T Lymphocytes 0.6849877065459009 16 T-cell adhesion/co-stimulation immune CD48-CD2 immune CD48-CD2 +MMRN2-CD93 Endothelial Cells Endothelial Cells 0.7107166026857937 10 CD93-MMRN2 angiogenesis vascular MMRN2-CD93 vascular MMRN2-CD93 +VWF-LRP1 Endothelial Cells CAFs, DCIS Associated 0.7479758913021439 2 vascular-stromal matrix/scavenger axis vascular VWF-LRP1 vascular VWF-LRP1 +VWF-SELP Endothelial Cells Endothelial Cells 0.7912892368005828 1 WPB / endothelial activation vascular VWF-SELP vascular VWF-SELP diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2c_vwf_selp_component_decomposition.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2c_vwf_selp_component_decomposition.tsv new file mode 100644 index 0000000..b9bf161 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2c_vwf_selp_component_decomposition.tsv @@ -0,0 +1,7 @@ +label x geomean_penalty target_lr target_sender target_receiver prior_confidence reported_lr_score recomputed_lr_score y value category +sender_anchor 0.955713094717548 0.0452975106374889 VWF-SELP Endothelial Cells Endothelial Cells 1.0 0.7912892368005828 0.7912892368005827 sender_anchor 0.955713094717548 component +receiver_anchor 0.8819126042133903 0.125662304739348 VWF-SELP Endothelial Cells Endothelial Cells 1.0 0.7912892368005828 0.7912892368005827 receiver_anchor 0.8819126042133903 component +structure_bridge 1.0 -9.999999889225293e-09 VWF-SELP Endothelial Cells Endothelial Cells 1.0 0.7912892368005828 0.7912892368005827 structure_bridge 1.0 component +sender_expr 1.0 -9.999999889225293e-09 VWF-SELP Endothelial Cells Endothelial Cells 1.0 0.7912892368005828 0.7912892368005827 sender_expr 1.0 component +receiver_expr 1.0 -9.999999889225293e-09 VWF-SELP Endothelial Cells Endothelial Cells 1.0 0.7912892368005828 0.7912892368005827 receiver_expr 1.0 component +local_contact 0.2912449657481761 1.23359052490106 VWF-SELP Endothelial Cells Endothelial Cells 1.0 0.7912892368005828 0.7912892368005827 local_contact 0.2912449657481761 component diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2d_vwf_selp_rank_sensitivity.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2d_vwf_selp_rank_sensitivity.tsv new file mode 100644 index 0000000..29475a0 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2d_vwf_selp_rank_sensitivity.tsv @@ -0,0 +1,11 @@ +scenario target_score target_rank top_ligand top_receptor top_sender top_receiver top_score x y value category label +original 0.7912892368005827 1 VWF SELP Endothelial Cells Endothelial Cells 0.7912892368005827 1 original 0.7912892368005827 rank_sensitivity original +remove_sender_anchor 0.7619681211528222 1 VWF SELP Endothelial Cells Endothelial Cells 0.7619681211528222 1 remove_sender_anchor 0.7619681211528222 rank_sensitivity remove_sender_anchor +set_sender_anchor_to_1 0.7972857506756545 1 VWF SELP Endothelial Cells Endothelial Cells 0.7972857506756545 1 set_sender_anchor_to_1 0.7972857506756545 rank_sensitivity set_sender_anchor_to_1 +remove_receiver_anchor 0.7743141562550239 1 VWF SELP Endothelial Cells Endothelial Cells 0.7743141562550239 1 remove_receiver_anchor 0.7743141562550239 rank_sensitivity remove_receiver_anchor +set_receiver_anchor_to_1 0.8080365395595056 1 VWF SELP Endothelial Cells Endothelial Cells 0.8080365395595056 1 set_receiver_anchor_to_1 0.8080365395595056 rank_sensitivity set_receiver_anchor_to_1 +remove_structure_bridge 0.7550962427202288 1 VWF SELP Endothelial Cells Endothelial Cells 0.7550962427202288 1 remove_structure_bridge 0.7550962427202288 rank_sensitivity remove_structure_bridge +set_structure_bridge_to_1 0.7912892368005827 1 VWF SELP Endothelial Cells Endothelial Cells 0.7912892368005827 1 set_structure_bridge_to_1 0.7912892368005827 rank_sensitivity set_structure_bridge_to_1 +remove_sender_expr 0.7550962427202288 1 VWF SELP Endothelial Cells Endothelial Cells 0.7550962427202288 1 remove_sender_expr 0.7550962427202288 rank_sensitivity remove_sender_expr +set_sender_expr_to_1 0.7912892368005827 1 VWF SELP Endothelial Cells Endothelial Cells 0.7912892368005827 1 set_sender_expr_to_1 0.7912892368005827 rank_sensitivity set_sender_expr_to_1 +remove_receiver_expr 0.7550962427202288 1 VWF SELP Endothelial Cells Endothelial Cells 0.7550962427202288 1 remove_receiver_expr 0.7550962427202288 rank_sensitivity remove_receiver_expr diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2e_expression_specificity_dotplot.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2e_expression_specificity_dotplot.tsv new file mode 100644 index 0000000..373ff06 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2e_expression_specificity_dotplot.tsv @@ -0,0 +1,261 @@ +gene cell_type n_cells mean_raw mean_log1p detection_fraction mean_log1p_norm_by_gene detection_norm_by_gene x y value category label +CLEC14A 11q13 Invasive Tumor Cells 64036 0.0398838153538634 0.0264680911599 0.0359485289524642 0.041557481697445 0.0609795660279409 10 7 0.041557481697445 endothelial_or_axis_marker CLEC14A|11q13 Invasive Tumor Cells +EMCN 11q13 Invasive Tumor Cells 64036 0.0466456368292835 0.0306939309471538 0.0412580423511774 0.0438564551449711 0.0650593083263036 10 3 0.0438564551449711 endothelial_or_axis_marker EMCN|11q13 Invasive Tumor Cells +FLT1 11q13 Invasive Tumor Cells 64036 0.1213223811605971 0.0788451112156392 0.1039727653195077 0.1127899234129754 0.1685453248337284 10 5 0.1127899234129754 endothelial_or_axis_marker FLT1|11q13 Invasive Tumor Cells +GP1BA 11q13 Invasive Tumor Cells 64036 0.0122899618964332 0.0083308810678187 0.0116496970454119 0.3329924716816997 0.3582281841464176 10 11 0.3329924716816997 contamination_control GP1BA|11q13 Invasive Tumor Cells +HBB 11q13 Invasive Tumor Cells 64036 0.0137266537572615 0.0091192711403616 0.0124461240552189 0.1391703020625389 0.2250217481178367 10 12 0.1391703020625389 contamination_control HBB|11q13 Invasive Tumor Cells +ITGA2B 11q13 Invasive Tumor Cells 64036 0.0111812105690549 0.0075541820553332 0.010525329502155 0.0956136919166066 0.1044893598157488 10 10 0.0956136919166066 contamination_control ITGA2B|11q13 Invasive Tumor Cells +KDR 11q13 Invasive Tumor Cells 64036 0.0382909613342494 0.0248978279213703 0.033496783059529 0.0289646436847441 0.0525611821516336 10 4 0.0289646436847441 endothelial_or_axis_marker KDR|11q13 Invasive Tumor Cells +MMRN2 11q13 Invasive Tumor Cells 64036 0.0198013617340246 0.0127775449038571 0.0168967455806109 0.021414330386234 0.0299706980434365 10 6 0.021414330386234 endothelial_or_axis_marker MMRN2|11q13 Invasive Tumor Cells +PECAM1 11q13 Invasive Tumor Cells 64036 0.0740520956961709 0.0484797119319033 0.0648853769754513 0.0337595881679162 0.0727566624673374 10 2 0.0337595881679162 endothelial_or_axis_marker PECAM1|11q13 Invasive Tumor Cells +PF4 11q13 Invasive Tumor Cells 64036 0.0104628646386407 0.0071561231872387 0.0101349241051908 0.2936332728024037 0.2942747606257194 10 9 0.2936332728024037 contamination_control PF4|11q13 Invasive Tumor Cells +PPBP 11q13 Invasive Tumor Cells 64036 0.0200668374039602 0.0135668158922899 0.0188956212130676 0.5162658763147775 0.5169002158508061 10 8 0.5162658763147775 contamination_control PPBP|11q13 Invasive Tumor Cells +SELP 11q13 Invasive Tumor Cells 64036 0.0167718158535823 0.0112277514672464 0.015444437503904 0.0358242679564606 0.0595142220883237 10 1 0.0358242679564606 endothelial_or_axis_marker SELP|11q13 Invasive Tumor Cells +VWF 11q13 Invasive Tumor Cells 64036 0.0526422637266537 0.033807260687592 0.0445842963333125 0.0203868912709569 0.0507718171898173 10 0 0.0203868912709569 endothelial_or_axis_marker VWF|11q13 Invasive Tumor Cells +CLEC14A 11q13 Invasive Tumor Cells (G1/S) 2374 0.0261162594776748 0.0179812313067669 0.0256950294860994 0.0282322849205162 0.0435865331015187 16 7 0.0282322849205162 endothelial_or_axis_marker CLEC14A|11q13 Invasive Tumor Cells (G1/S) +EMCN 11q13 Invasive Tumor Cells (G1/S) 2374 0.0290648694187026 0.0186424547403363 0.0240101095197978 0.0266369264177785 0.0378612515082714 16 3 0.0266369264177785 endothelial_or_axis_marker EMCN|11q13 Invasive Tumor Cells (G1/S) +FLT1 11q13 Invasive Tumor Cells (G1/S) 2374 0.0766638584667228 0.0508588641476264 0.0690817186183656 0.0727548899816109 0.1119851017602979 16 5 0.0727548899816109 endothelial_or_axis_marker FLT1|11q13 Invasive Tumor Cells (G1/S) +GP1BA 11q13 Invasive Tumor Cells (G1/S) 2374 0.0016849199663016 0.0011678975241111 0.0016849199663016 0.0466818671469189 0.0518112889637742 16 11 0.0466818671469189 contamination_control GP1BA|11q13 Invasive Tumor Cells (G1/S) +HBB 11q13 Invasive Tumor Cells (G1/S) 2374 0.0080033698399326 0.0053051526056172 0.0071609098567818 0.080962576860319 0.1294668482282731 16 12 0.080962576860319 contamination_control HBB|11q13 Invasive Tumor Cells (G1/S) +ITGA2B 11q13 Invasive Tumor Cells (G1/S) 2374 0.0143218197135636 0.0096351545739166 0.0134793597304128 0.1219526739296609 0.1338152566785335 16 10 0.1219526739296609 contamination_control ITGA2B|11q13 Invasive Tumor Cells (G1/S) +KDR 11q13 Invasive Tumor Cells (G1/S) 2374 0.0438079191238416 0.025524522357307 0.0320134793597304 0.0296937025043906 0.0502336692136672 16 4 0.0296937025043906 endothelial_or_axis_marker KDR|11q13 Invasive Tumor Cells (G1/S) +MMRN2 11q13 Invasive Tumor Cells (G1/S) 2374 0.0181128896377422 0.0123125377502839 0.0172704296545914 0.0206350087799705 0.0306335222832571 16 6 0.0206350087799705 endothelial_or_axis_marker MMRN2|11q13 Invasive Tumor Cells (G1/S) +PECAM1 11q13 Invasive Tumor Cells (G1/S) 2374 0.0543386689132266 0.0336271429289932 0.0450716090985678 0.0234167747972815 0.0505392740691781 16 2 0.0234167747972815 endothelial_or_axis_marker PECAM1|11q13 Invasive Tumor Cells (G1/S) +PF4 11q13 Invasive Tumor Cells (G1/S) 2374 0.0088458298230834 0.006010281684628 0.008424599831508 0.246616587689383 0.2446142736791431 16 9 0.246616587689383 contamination_control PF4|11q13 Invasive Tumor Cells (G1/S) +PPBP 11q13 Invasive Tumor Cells (G1/S) 2374 0.0134793597304128 0.0089796392420231 0.0122156697556866 0.3417073953887903 0.3341664326500047 16 8 0.3417073953887903 contamination_control PPBP|11q13 Invasive Tumor Cells (G1/S) +SELP 11q13 Invasive Tumor Cells (G1/S) 2374 0.0130581297388374 0.0086876648609953 0.0117944397641112 0.0277196404644458 0.0454491727103194 16 1 0.0277196404644458 endothelial_or_axis_marker SELP|11q13 Invasive Tumor Cells (G1/S) +VWF 11q13 Invasive Tumor Cells (G1/S) 2374 0.0438079191238416 0.0262285559090642 0.033698399326032 0.0158166827668637 0.0383751479978476 16 0 0.0158166827668637 endothelial_or_axis_marker VWF|11q13 Invasive Tumor Cells (G1/S) +CLEC14A 11q13 Invasive Tumor Cells (Mitotic) 2462 0.0649878147847278 0.0430808568883224 0.058489033306255 0.067641142341202 0.0992150714463304 0 7 0.067641142341202 endothelial_or_axis_marker CLEC14A|11q13 Invasive Tumor Cells (Mitotic) +EMCN 11q13 Invasive Tumor Cells (Mitotic) 2462 0.0905767668562144 0.0581035691849789 0.0751421608448416 0.0830202094385059 0.1184907652451844 0 3 0.0830202094385059 endothelial_or_axis_marker EMCN|11q13 Invasive Tumor Cells (Mitotic) +FLT1 11q13 Invasive Tumor Cells (Mitotic) 2462 0.2465475223395613 0.1585772686289839 0.2063363119415109 0.2268487888207098 0.3344820214630809 0 5 0.2268487888207098 endothelial_or_axis_marker FLT1|11q13 Invasive Tumor Cells (Mitotic) +GP1BA 11q13 Invasive Tumor Cells (Mitotic) 2462 0.033306255077173 0.0228524389362355 0.0324939073923639 0.913431612260985 0.9991876523151908 0 11 0.913431612260985 contamination_control GP1BA|11q13 Invasive Tumor Cells (Mitotic) +HBB 11q13 Invasive Tumor Cells (Mitotic) 2462 0.0308692120227457 0.0203452668848455 0.0272136474411047 0.3104915836283197 0.4920136174676892 0 12 0.3104915836283197 contamination_control HBB|11q13 Invasive Tumor Cells (Mitotic) +ITGA2B 11q13 Invasive Tumor Cells (Mitotic) 2462 0.1246953696181965 0.0790073252471198 0.1007311129163281 1.0 1.0 0 10 1.0 contamination_control ITGA2B|11q13 Invasive Tumor Cells (Mitotic) +KDR 11q13 Invasive Tumor Cells (Mitotic) 2462 0.0629569455727051 0.0421405613509575 0.0580828594638505 0.0490238083442582 0.0911402074265369 0 4 0.0490238083442582 endothelial_or_axis_marker KDR|11q13 Invasive Tumor Cells (Mitotic) +MMRN2 11q13 Invasive Tumor Cells (Mitotic) 2462 0.0422420796100731 0.0271288572048927 0.0349309504467912 0.0454661921016744 0.061958970928245 0 6 0.0454661921016744 endothelial_or_axis_marker MMRN2|11q13 Invasive Tumor Cells (Mitotic) +PECAM1 11q13 Invasive Tumor Cells (Mitotic) 2462 0.1673436230706742 0.1075963014386392 0.1393176279447603 0.0749263285652699 0.1562183361585767 0 2 0.0749263285652699 endothelial_or_axis_marker PECAM1|11q13 Invasive Tumor Cells (Mitotic) +PF4 11q13 Invasive Tumor Cells (Mitotic) 2462 0.0219333874898456 0.0152030656987152 0.0219333874898456 0.6238190457235915 0.6368515724730184 0 9 0.6238190457235915 contamination_control PF4|11q13 Invasive Tumor Cells (Mitotic) +PPBP 11q13 Invasive Tumor Cells (Mitotic) 2462 0.0389926888708367 0.0262787383685571 0.0365556458164094 1.0 1.0 0 8 1.0 contamination_control PPBP|11q13 Invasive Tumor Cells (Mitotic) +SELP 11q13 Invasive Tumor Cells (Mitotic) 2462 0.0341186027619821 0.0226665814588808 0.0308692120227457 0.0723220219300986 0.1189526740322427 0 1 0.0723220219300986 endothelial_or_axis_marker SELP|11q13 Invasive Tumor Cells (Mitotic) +VWF 11q13 Invasive Tumor Cells (Mitotic) 2462 0.111697806661251 0.0716813682035306 0.0942323314378554 0.0432262250770041 0.1073101315621372 0 0 0.0432262250770041 endothelial_or_axis_marker VWF|11q13 Invasive Tumor Cells (Mitotic) +CLEC14A Apocrine Cells 403 0.0471464019851116 0.0312516930167131 0.0421836228287841 0.0490682026410676 0.0715561690156243 6 7 0.0490682026410676 endothelial_or_axis_marker CLEC14A|Apocrine Cells +EMCN Apocrine Cells 403 0.0471464019851116 0.0305378417203067 0.0397022332506203 0.0436334299421184 0.0626059717596178 6 3 0.0436334299421184 endothelial_or_axis_marker EMCN|Apocrine Cells +FLT1 Apocrine Cells 403 0.1563275434243176 0.1055025907828025 0.1464019851116625 0.1509241213664805 0.2373253232336424 6 5 0.1509241213664805 endothelial_or_axis_marker FLT1|Apocrine Cells +GP1BA Apocrine Cells 403 0.0248138957816377 0.0171996818997505 0.0248138957816377 0.6874860583547492 0.7630272952853597 6 11 0.6874860583547492 contamination_control GP1BA|Apocrine Cells +HBB Apocrine Cells 403 0.0173697270471464 0.0120397773298253 0.0173697270471464 0.1837405009640988 0.3140388386888691 6 12 0.1837405009640988 contamination_control HBB|Apocrine Cells +ITGA2B Apocrine Cells 403 0.0272952853598014 0.0189196500897255 0.0272952853598014 0.2394670371455872 0.2709717441767389 6 10 0.2394670371455872 contamination_control ITGA2B|Apocrine Cells +KDR Apocrine Cells 403 0.0719602977667493 0.0450114385365135 0.0570719602977667 0.0523636151340271 0.0895539639024636 6 4 0.0523636151340271 endothelial_or_axis_marker KDR|Apocrine Cells +MMRN2 Apocrine Cells 403 0.0124069478908188 0.0085998409498752 0.0124069478908188 0.0144127715265631 0.0220068939963845 6 6 0.0144127715265631 endothelial_or_axis_marker MMRN2|Apocrine Cells +PECAM1 Apocrine Cells 403 0.0719602977667493 0.0474452580228949 0.064516129032258 0.0330392303820476 0.0723426208261856 6 2 0.0330392303820476 endothelial_or_axis_marker PECAM1|Apocrine Cells +PF4 Apocrine Cells 403 0.0173697270471464 0.0120397773298253 0.0173697270471464 0.4940215712710401 0.5043424317617866 6 9 0.4940215712710401 contamination_control PF4|Apocrine Cells +PPBP Apocrine Cells 403 0.0074441687344913 0.0051599045699251 0.0074441687344913 0.1963528270481602 0.2036393713813068 6 8 0.1963528270481602 contamination_control PPBP|Apocrine Cells +SELP Apocrine Cells 403 0.0297766749379652 0.0206396182797006 0.0297766749379652 0.0658546119343693 0.1147426473034014 6 1 0.0658546119343693 endothelial_or_axis_marker SELP|Apocrine Cells +VWF Apocrine Cells 403 0.0620347394540942 0.040857650860157 0.0545905707196029 0.0246385086733293 0.0621667875195901 6 0 0.0246385086733293 endothelial_or_axis_marker VWF|Apocrine Cells +CLEC14A B Cells 2512 0.0187101910828025 0.0120058431015313 0.0155254777070063 0.0188503433035694 0.0263359008153467 17 7 0.0188503433035694 endothelial_or_axis_marker CLEC14A|B Cells +EMCN B Cells 2512 0.0147292993630573 0.0098660029710838 0.0135350318471337 0.0140968557434515 0.0213432281312271 17 3 0.0140968557434515 endothelial_or_axis_marker EMCN|B Cells +FLT1 B Cells 2512 0.0322452229299363 0.0207212203728157 0.0270700636942675 0.029642229211666 0.043881997988602 17 5 0.029642229211666 endothelial_or_axis_marker FLT1|B Cells +GP1BA B Cells 2512 0.0047770700636942 0.0029207551408071 0.0035828025477707 0.1167450916171898 0.110171178343949 17 11 0.1167450916171898 contamination_control GP1BA|B Cells +HBB B Cells 2512 0.0067675159235668 0.0040244926894695 0.0051751592356687 0.0614182706733004 0.0935651430784227 17 12 0.0614182706733004 contamination_control HBB|B Cells +ITGA2B B Cells 2512 0.0035828025477707 0.0024834094844902 0.0035828025477707 0.0314326485135728 0.0355679833573042 17 10 0.0314326485135728 contamination_control ITGA2B|B Cells +KDR B Cells 2512 0.0207006369426751 0.013270991919345 0.0171178343949044 0.0154386781650545 0.0268602990941877 17 4 0.0154386781650545 endothelial_or_axis_marker KDR|B Cells +MMRN2 B Cells 2512 0.0103503184713375 0.0067162015942481 0.0087579617834394 0.011255915041736 0.0155344842493587 17 6 0.011255915041736 endothelial_or_axis_marker MMRN2|B Cells +PECAM1 B Cells 2512 0.2121815286624203 0.1101852870632928 0.116640127388535 0.0767292082643847 0.130789813886195 17 2 0.0767292082643847 endothelial_or_axis_marker PECAM1|B Cells +PF4 B Cells 2512 0.0039808917197452 0.0027593438716558 0.0039808917197452 0.1132226417323869 0.115588034576888 17 9 0.1132226417323869 contamination_control PF4|B Cells +PPBP B Cells 2512 0.009156050955414 0.0063464909048084 0.009156050955414 0.2415066817820325 0.2504688605803255 17 8 0.2415066817820325 contamination_control PPBP|B Cells +SELP B Cells 2512 0.0071656050955414 0.0048522958509662 0.0067675159235668 0.0154821690946877 0.0260782204311174 17 1 0.0154821690946877 endothelial_or_axis_marker SELP|B Cells +VWF B Cells 2512 0.0342356687898089 0.0195710439219732 0.0222929936305732 0.0118019838455243 0.0253868713944359 17 0 0.0118019838455243 endothelial_or_axis_marker VWF|B Cells +CLEC14A Basal-like Structured DCIS Cells 8760 0.0340182648401826 0.0217730809223095 0.0286529680365296 0.0341858582267813 0.0486040905481966 14 7 0.0341858582267813 endothelial_or_axis_marker CLEC14A|Basal-like Structured DCIS Cells +EMCN Basal-like Structured DCIS Cells 8760 0.030593607305936 0.0203057357760514 0.0275114155251141 0.0290134747413515 0.0433824186302037 14 3 0.0290134747413515 endothelial_or_axis_marker EMCN|Basal-like Structured DCIS Cells +FLT1 Basal-like Structured DCIS Cells 8760 0.0818493150684931 0.0532775213329842 0.0707762557077625 0.07621484018642 0.1147320355683729 14 5 0.07621484018642 endothelial_or_axis_marker FLT1|Basal-like Structured DCIS Cells +GP1BA Basal-like Structured DCIS Cells 8760 0.014269406392694 0.0097131511611961 0.0136986301369863 0.3882429945469764 0.4212328767123287 14 11 0.3882429945469764 contamination_control GP1BA|Basal-like Structured DCIS Cells +HBB Basal-like Structured DCIS Cells 8760 0.0159817351598173 0.0091534459384017 0.0115296803652968 0.1396918477971655 0.2084527536065401 14 12 0.1396918477971655 contamination_control HBB|Basal-like Structured DCIS Cells +ITGA2B Basal-like Structured DCIS Cells 8760 0.0100456621004566 0.0067989202656411 0.0094748858447488 0.0860543024887299 0.0940611651200471 14 10 0.0860543024887299 contamination_control ITGA2B|Basal-like Structured DCIS Cells +KDR Basal-like Structured DCIS Cells 8760 0.0836757990867579 0.050134376117882 0.0606164383561643 0.0583233342762806 0.0951157504336902 14 4 0.0583233342762806 endothelial_or_axis_marker KDR|Basal-like Structured DCIS Cells +MMRN2 Basal-like Structured DCIS Cells 8760 0.0674657534246575 0.0420943176594778 0.0531963470319634 0.0705473259946077 0.094357321432261 14 6 0.0705473259946077 endothelial_or_axis_marker MMRN2|Basal-like Structured DCIS Cells +PECAM1 Basal-like Structured DCIS Cells 8760 0.0501141552511415 0.0311493000356866 0.0394977168949771 0.0216912910373878 0.044289209530917 14 2 0.0216912910373878 endothelial_or_axis_marker PECAM1|Basal-like Structured DCIS Cells +PF4 Basal-like Structured DCIS Cells 8760 0.0075342465753424 0.0051566609328827 0.0073059360730593 0.2115904361672836 0.212133072407045 14 9 0.2115904361672836 contamination_control PF4|Basal-like Structured DCIS Cells +PPBP Basal-like Structured DCIS Cells 8760 0.011986301369863 0.0081769093229437 0.0115296803652968 0.3111606504187248 0.3154008117706748 14 8 0.3111606504187248 contamination_control PPBP|Basal-like Structured DCIS Cells +SELP Basal-like Structured DCIS Cells 8760 0.0126712328767123 0.0083948936271542 0.0114155251141552 0.0267854983825105 0.043989047624877 14 1 0.0267854983825105 endothelial_or_axis_marker SELP|Basal-like Structured DCIS Cells +VWF Basal-like Structured DCIS Cells 8760 0.0597031963470319 0.0357247227005931 0.0440639269406392 0.0215431839956612 0.0501792296231444 14 0 0.0215431839956612 endothelial_or_axis_marker VWF|Basal-like Structured DCIS Cells +CLEC14A CAFs, DCIS Associated 24442 0.0515506096064151 0.0323206068480466 0.0411177481384502 0.0507465014920662 0.069748123514161 9 7 0.0507465014920662 endothelial_or_axis_marker CLEC14A|CAFs, DCIS Associated +EMCN CAFs, DCIS Associated 24442 0.0415268799607233 0.0268165331788122 0.035226249897717 0.0383163071072609 0.0555478477085229 9 3 0.0383163071072609 endothelial_or_axis_marker EMCN|CAFs, DCIS Associated +FLT1 CAFs, DCIS Associated 24442 0.0830537599214466 0.0543076057896063 0.0724572457245724 0.0776884020240531 0.1174570088587806 9 5 0.0776884020240531 endothelial_or_axis_marker FLT1|CAFs, DCIS Associated +GP1BA CAFs, DCIS Associated 24442 0.0198838065624744 0.0131729225135657 0.018001800180018 0.5265330271018102 0.5535553555355535 9 11 0.5265330271018102 contamination_control GP1BA|CAFs, DCIS Associated +HBB CAFs, DCIS Associated 24442 0.0133376974061042 0.007988252819741 0.010187382374601 0.1219096944003347 0.1841844561814672 9 12 0.1219096944003347 contamination_control HBB|CAFs, DCIS Associated +ITGA2B CAFs, DCIS Associated 24442 0.0199247197447017 0.0134148481495626 0.0186154979134277 0.1697924604788679 0.1848038542857218 9 10 0.1697924604788679 contamination_control ITGA2B|CAFs, DCIS Associated +KDR CAFs, DCIS Associated 24442 0.0457818509123639 0.0282488982848719 0.0357581212666721 0.0328630784939114 0.0561095410851128 9 4 0.0328630784939114 endothelial_or_axis_marker KDR|CAFs, DCIS Associated +MMRN2 CAFs, DCIS Associated 24442 0.0258571311676622 0.0165633741955356 0.0216430733982489 0.0277591329166023 0.0383895238557175 9 6 0.0277591329166023 endothelial_or_axis_marker MMRN2|CAFs, DCIS Associated +PECAM1 CAFs, DCIS Associated 24442 0.0796988789788069 0.0471977616614245 0.0569511496604205 0.0328668825090231 0.0638599290952369 9 2 0.0328668825090231 endothelial_or_axis_marker PECAM1|CAFs, DCIS Associated +PF4 CAFs, DCIS Associated 24442 0.0086326814499631 0.0059248688624453 0.0084281155388266 0.2431118902630549 0.2447163547523583 9 9 0.2431118902630549 contamination_control PF4|CAFs, DCIS Associated +PPBP CAFs, DCIS Associated 24442 0.0110465592013746 0.0074049027163915 0.010187382374601 0.281783037394656 0.2786815045140878 9 8 0.281783037394656 contamination_control PPBP|CAFs, DCIS Associated +SELP CAFs, DCIS Associated 24442 0.0214385074871123 0.0140318842334462 0.0187791506423369 0.044771384740697 0.0723643409917399 9 1 0.044771384740697 endothelial_or_axis_marker SELP|CAFs, DCIS Associated +VWF CAFs, DCIS Associated 24442 0.072539072089027 0.0409118728978425 0.0477865968415023 0.0246712063472698 0.0544185410221994 9 0 0.0246712063472698 endothelial_or_axis_marker VWF|CAFs, DCIS Associated +CLEC14A CAFs, Invasive Associated 4001 0.0717320669832541 0.0434648940221394 0.0537365658585353 0.0682441180549896 0.0911534508190418 15 7 0.0682441180549896 endothelial_or_axis_marker CLEC14A|CAFs, Invasive Associated +EMCN CAFs, Invasive Associated 4001 0.0354911272181954 0.0224370067264638 0.0287428142964258 0.0320587017928969 0.0453241964696245 15 3 0.0320587017928969 endothelial_or_axis_marker EMCN|CAFs, Invasive Associated +FLT1 CAFs, Invasive Associated 4001 0.0722319420144963 0.0457991076729008 0.0587353161709572 0.0655167805227785 0.0952130388455517 15 5 0.0655167805227785 endothelial_or_axis_marker FLT1|CAFs, Invasive Associated +GP1BA CAFs, Invasive Associated 4001 0.0137465633591602 0.0088781638987084 0.0117470632341914 0.3548678364940589 0.3612221944513871 15 11 0.3548678364940589 contamination_control GP1BA|CAFs, Invasive Associated +HBB CAFs, Invasive Associated 4001 0.0224943764058985 0.0082961082251694 0.0087478130467383 0.126607913052419 0.1581575256081157 15 12 0.126607913052419 contamination_control HBB|CAFs, Invasive Associated +ITGA2B CAFs, Invasive Associated 4001 0.0077480629842539 0.0052986454698591 0.0074981254686328 0.0670652430427939 0.0744370359023147 15 10 0.0670652430427939 contamination_control ITGA2B|CAFs, Invasive Associated +KDR CAFs, Invasive Associated 4001 0.1054736315921019 0.0591636561965484 0.0672331917020744 0.0688274586133218 0.1054983706766176 15 4 0.0688274586133218 endothelial_or_axis_marker KDR|CAFs, Invasive Associated +MMRN2 CAFs, Invasive Associated 4001 0.0217445638590352 0.0138334272538159 0.0177455636090977 0.0231839202144166 0.0314762938224719 15 6 0.0231839202144166 endothelial_or_axis_marker MMRN2|CAFs, Invasive Associated +PECAM1 CAFs, Invasive Associated 4001 0.1074731317170707 0.0636215144819947 0.076730817295676 0.044303813738584 0.0860390805302185 15 2 0.044303813738584 endothelial_or_axis_marker PECAM1|CAFs, Invasive Associated +PF4 CAFs, Invasive Associated 4001 0.0022494376405898 0.0015591913584202 0.0022494376405898 0.0639774427464584 0.0653140286356982 15 9 0.0639774427464584 contamination_control PF4|CAFs, Invasive Associated +PPBP CAFs, Invasive Associated 4001 0.005498625343664 0.0035956490264842 0.0047488127968008 0.1368273079192601 0.1299064122858174 15 8 0.1368273079192601 contamination_control PPBP|CAFs, Invasive Associated +SELP CAFs, Invasive Associated 4001 0.0157460634841289 0.0093978943515151 0.0117470632341914 0.0299857621944455 0.045266610067769 15 1 0.0299857621944455 endothelial_or_axis_marker SELP|CAFs, Invasive Associated +VWF CAFs, Invasive Associated 4001 0.0932266933266683 0.0503121527555694 0.0552361909522619 0.0303398845979859 0.0629020085530578 15 0 0.0303398845979859 endothelial_or_axis_marker VWF|CAFs, Invasive Associated +CLEC14A CXCL14+ Fibroblasts 4936 0.012965964343598 0.0085316205383633 0.011547811993517 0.0133954754134191 0.0195885780157534 18 7 0.0133954754134191 endothelial_or_axis_marker CLEC14A|CXCL14+ Fibroblasts +EMCN CXCL14+ Fibroblasts 4936 0.0095218800648298 0.0061657085541936 0.0083063209076175 0.0088097585516016 0.0130981370464972 18 3 0.0088097585516016 endothelial_or_axis_marker EMCN|CXCL14+ Fibroblasts +FLT1 CXCL14+ Fibroblasts 4936 0.0117504051863857 0.0078877684657644 0.0109400324149108 0.0112836520544648 0.0177343683357502 18 5 0.0112836520544648 endothelial_or_axis_marker FLT1|CXCL14+ Fibroblasts +GP1BA CXCL14+ Fibroblasts 4936 0.0012155591572123 0.0008425614026255 0.0012155591572123 0.0336779029396633 0.0373784440842787 18 11 0.0336779029396633 contamination_control GP1BA|CXCL14+ Fibroblasts +HBB CXCL14+ Fibroblasts 4936 0.0097244732576985 0.0040597003515462 0.0040518638573743 0.0619555790711662 0.0732563394255697 18 12 0.0619555790711662 contamination_control HBB|CXCL14+ Fibroblasts +ITGA2B CXCL14+ Fibroblasts 4936 0.0010129659643435 0.0007021345021879 0.0010129659643435 0.0088869544689914 0.0100561379202174 18 10 0.0088869544689914 contamination_control ITGA2B|CXCL14+ Fibroblasts +KDR CXCL14+ Fibroblasts 4936 0.0212722852512155 0.0133277091056395 0.0170178282009724 0.0155046595469249 0.0267033752556743 18 4 0.0155046595469249 endothelial_or_axis_marker KDR|CXCL14+ Fibroblasts +MMRN2 CXCL14+ Fibroblasts 4936 0.0036466774716369 0.0024111193486984 0.0032414910858995 0.0040408784881736 0.0057496131478398 18 6 0.0040408784881736 endothelial_or_axis_marker MMRN2|CXCL14+ Fibroblasts +PECAM1 CXCL14+ Fibroblasts 4936 0.023095623987034 0.014339592885942 0.0176256077795786 0.0099855946133708 0.0197637812366513 18 2 0.0099855946133708 endothelial_or_axis_marker PECAM1|CXCL14+ Fibroblasts +PF4 CXCL14+ Fibroblasts 4936 0.0016207455429497 0.0011234152035007 0.0016207455429497 0.0460964790975293 0.047059504514934 18 9 0.0460964790975293 contamination_control PF4|CXCL14+ Fibroblasts +PPBP CXCL14+ Fibroblasts 4936 0.0024311183144246 0.0016268403756619 0.0022285251215559 0.061907095875216 0.060962542769674 18 8 0.061907095875216 contamination_control PPBP|CXCL14+ Fibroblasts +SELP CXCL14+ Fibroblasts 4936 0.0018233387358184 0.0012638421039383 0.0018233387358184 0.0040325276452923 0.0070261274609913 18 1 0.0040325276452923 endothelial_or_axis_marker SELP|CXCL14+ Fibroblasts +VWF CXCL14+ Fibroblasts 4936 0.0212722852512155 0.0130493720227543 0.0160048622366288 0.0078692009695953 0.0182260572994437 18 0 0.0078692009695953 endothelial_or_axis_marker VWF|CXCL14+ Fibroblasts +CLEC14A Dendritic Cells 4008 0.0399201596806387 0.0250244204532524 0.0316866267465069 0.0392907780426103 0.0537500922623674 7 7 0.0392907780426103 endothelial_or_axis_marker CLEC14A|Dendritic Cells +EMCN Dendritic Cells 4008 0.0326846307385229 0.0205833496806416 0.0261976047904191 0.0294101382307964 0.04131068636178 7 3 0.0294101382307964 endothelial_or_axis_marker EMCN|Dendritic Cells +FLT1 Dendritic Cells 4008 0.0980538922155688 0.0636484698575915 0.0843313373253493 0.0910507440462188 0.1367055362958293 7 5 0.0910507440462188 endothelial_or_axis_marker FLT1|Dendritic Cells +GP1BA Dendritic Cells 4008 0.0259481037924151 0.0168504265519323 0.0222055888223552 0.6735260221267357 0.6828218562874251 7 11 0.6735260221267357 contamination_control GP1BA|Dendritic Cells +HBB Dendritic Cells 4008 0.0184630738522954 0.0117045891317719 0.0149700598802395 0.1786251532512284 0.2706536612309971 7 12 0.1786251532512284 contamination_control HBB|Dendritic Cells +ITGA2B Dendritic Cells 4008 0.0137225548902195 0.0092246423754964 0.0127245508982035 0.1167567987733232 0.1263219528684566 7 10 0.1167567987733232 contamination_control ITGA2B|Dendritic Cells +KDR Dendritic Cells 4008 0.0531437125748503 0.0324346492072382 0.0409181636726546 0.037732530736987 0.0642063761850389 7 4 0.037732530736987 endothelial_or_axis_marker KDR|Dendritic Cells +MMRN2 Dendritic Cells 4008 0.0229540918163672 0.0140084955435966 0.0174650698602794 0.0234773232292935 0.0309787664490024 7 6 0.0234773232292935 endothelial_or_axis_marker MMRN2|Dendritic Cells +PECAM1 Dendritic Cells 4008 0.7437624750499002 0.3970185759349767 0.4149201596806387 0.2764699517481468 0.4652543826662109 7 2 0.2764699517481468 endothelial_or_axis_marker PECAM1|Dendritic Cells +PF4 Dendritic Cells 4008 0.0054890219560878 0.0038047000928939 0.0054890219560878 0.1561161694785087 0.1593776732249786 7 9 0.1561161694785087 contamination_control PF4|Dendritic Cells +PPBP Dendritic Cells 4008 0.0147205588822355 0.0096716881512519 0.0129740518962075 0.3680423320026765 0.3549123974273674 7 8 0.3680423320026765 contamination_control PPBP|Dendritic Cells +SELP Dendritic Cells 4008 0.0197105788423153 0.0128140115758366 0.0172155688622754 0.0408855313220201 0.0663391715229059 7 1 0.0408855313220201 endothelial_or_axis_marker SELP|Dendritic Cells +VWF Dendritic Cells 4008 0.1105289421157684 0.0552210056229069 0.0591317365269461 0.0333000844969462 0.0673381877470465 7 0 0.0333000844969462 endothelial_or_axis_marker VWF|Dendritic Cells +CLEC14A Endothelial Cells 8624 1.3179499072356216 0.6369031538676542 0.589517625231911 1.0 1.0 3 7 1.0 endothelial_or_axis_marker CLEC14A|Endothelial Cells +EMCN Endothelial Cells 8624 1.4728664192949907 0.6998725922031905 0.6341604823747681 1.0 1.0 3 3 1.0 endothelial_or_axis_marker EMCN|Endothelial Cells +FLT1 Endothelial Cells 8624 1.5473098330241188 0.6990439290126235 0.6168831168831169 1.0 1.0 3 5 1.0 endothelial_or_axis_marker FLT1|Endothelial Cells +GP1BA Endothelial Cells 8624 0.0230751391465677 0.0157139435663449 0.022147495361781 0.6280998210665826 0.6810354823747681 3 11 0.6280998210665826 contamination_control GP1BA|Endothelial Cells +HBB Endothelial Cells 8624 0.222982374768089 0.0655259851075393 0.0553107606679035 1.0 1.0 3 12 1.0 contamination_control HBB|Endothelial Cells +ITGA2B Endothelial Cells 8624 0.0211038961038961 0.0142141487658664 0.0197124304267161 0.1799092517232712 0.1956935633490933 3 10 0.1799092517232712 contamination_control ITGA2B|Endothelial Cells +KDR Endothelial Cells 8624 2.37569573283859 0.8595937927758542 0.637291280148423 1.0 1.0 3 4 1.0 endothelial_or_axis_marker KDR|Endothelial Cells +MMRN2 Endothelial Cells 8624 1.2184601113172542 0.5966819729311267 0.5637755102040817 1.0 1.0 3 6 1.0 endothelial_or_axis_marker MMRN2|Endothelial Cells +PECAM1 Endothelial Cells 8624 4.5438311688311686 1.4360279423662103 0.8918135435992579 1.0 1.0 3 2 1.0 endothelial_or_axis_marker PECAM1|Endothelial Cells +PF4 Endothelial Cells 8624 0.009160482374768 0.0063495625306395 0.009160482374768 0.2605381123203701 0.2659811489530877 3 9 0.2605381123203701 contamination_control PF4|Endothelial Cells +PPBP Endothelial Cells 8624 0.0182050092764378 0.0122047935346513 0.0168135435992578 0.4644360533401633 0.4599438260152546 3 8 0.4644360533401633 contamination_control PPBP|Endothelial Cells +SELP Endothelial Cells 8624 0.7355055658627088 0.3134118883013089 0.2595083487940631 1.0 1.0 3 1 1.0 endothelial_or_axis_marker SELP|Endothelial Cells +VWF Endothelial Cells 8624 6.707908163265306 1.658284249337892 0.8781307977736549 1.0 1.0 3 0 1.0 endothelial_or_axis_marker VWF|Endothelial Cells +CLEC14A Luminal-like Amorphous DCIS Cells 13028 0.0388394227817009 0.0258947244362063 0.0354620816702486 0.0406572400826691 0.0601544044697531 13 7 0.0406572400826691 endothelial_or_axis_marker CLEC14A|Luminal-like Amorphous DCIS Cells +EMCN Luminal-like Amorphous DCIS Cells 13028 0.0459778937672704 0.0305304564582535 0.0414491863678231 0.0436228776471214 0.0653607210159273 13 3 0.0436228776471214 endothelial_or_axis_marker EMCN|Luminal-like Amorphous DCIS Cells +FLT1 Luminal-like Amorphous DCIS Cells 13028 0.0984034387473134 0.0644891177569788 0.0862757138470985 0.0922533121030999 0.1398574729731913 13 5 0.0922533121030999 endothelial_or_axis_marker FLT1|Luminal-like Amorphous DCIS Cells +GP1BA Luminal-like Amorphous DCIS Cells 13028 0.014276941971139 0.0096531219517332 0.013432606693276 0.3858435754856044 0.4130526558182376 13 11 0.3858435754856044 contamination_control GP1BA|Luminal-like Amorphous DCIS Cells +HBB Luminal-like Amorphous DCIS Cells 13028 0.0180380718452563 0.0117760896263026 0.0158120970217992 0.1797163309636028 0.2858774103060719 13 12 0.1797163309636028 contamination_control HBB|Luminal-like Amorphous DCIS Cells +ITGA2B Luminal-like Amorphous DCIS Cells 13028 0.0114369051274178 0.0077638449770197 0.0108996008596868 0.0982674068858285 0.1082049085344716 13 10 0.0982674068858285 contamination_control ITGA2B|Luminal-like Amorphous DCIS Cells +KDR Luminal-like Amorphous DCIS Cells 13028 0.052732575990175 0.0332318294154894 0.0436751611912803 0.0386599225061586 0.0685324945621545 13 4 0.0386599225061586 endothelial_or_axis_marker KDR|Luminal-like Amorphous DCIS Cells +MMRN2 Luminal-like Amorphous DCIS Cells 13028 0.0277863064169481 0.0178947711423567 0.0235646300276327 0.0299904672072644 0.0417978957956201 13 6 0.0299904672072644 endothelial_or_axis_marker MMRN2|Luminal-like Amorphous DCIS Cells +PECAM1 Luminal-like Amorphous DCIS Cells 13028 0.0814399754375191 0.0530433066285229 0.0703868590727663 0.0369375170660823 0.0789255327842331 13 2 0.0369375170660823 endothelial_or_axis_marker PECAM1|Luminal-like Amorphous DCIS Cells +PF4 Luminal-like Amorphous DCIS Cells 13028 0.0117439361375498 0.0080077852464661 0.0112833896223518 0.3285790543700732 0.3276212772490021 13 9 0.3285790543700732 contamination_control PF4|Luminal-like Amorphous DCIS Cells +PPBP Luminal-like Amorphous DCIS Cells 13028 0.0158888547743322 0.0108366602545513 0.0152747927540681 0.4123736879057146 0.417850441783509 13 8 0.4123736879057146 contamination_control PPBP|Luminal-like Amorphous DCIS Cells +SELP Luminal-like Amorphous DCIS Cells 13028 0.0183451028553883 0.0123535062909841 0.0171169788148603 0.0394162019760646 0.0659592606342069 13 1 0.0394162019760646 endothelial_or_axis_marker SELP|Luminal-like Amorphous DCIS Cells +VWF Luminal-like Amorphous DCIS Cells 13028 0.0628645993245317 0.0388471531536224 0.0492784771261897 0.0234261123623003 0.0561174682076139 13 0 0.0234261123623003 endothelial_or_axis_marker VWF|Luminal-like Amorphous DCIS Cells +CLEC14A Macrophages 3861 0.0217560217560217 0.0141995064228834 0.0189070189070189 0.0222946084293281 0.0320720163363751 12 7 0.0222946084293281 endothelial_or_axis_marker CLEC14A|Macrophages +EMCN Macrophages 3861 0.0326340326340326 0.0209639658435888 0.0271950271950271 0.0299539745907102 0.0428835096964553 12 3 0.0299539745907102 endothelial_or_axis_marker EMCN|Macrophages +FLT1 Macrophages 3861 0.0699300699300699 0.046158519417716 0.0624190624190624 0.0660309281033502 0.1011845853951117 12 5 0.0660309281033502 endothelial_or_axis_marker FLT1|Macrophages +GP1BA Macrophages 3861 0.0152810152810152 0.0103684634643049 0.0145040145040145 0.4144363901505435 0.4459984459984459 12 11 0.4144363901505435 contamination_control GP1BA|Macrophages +HBB Macrophages 3861 0.0129500129500129 0.0079906306789968 0.0098420098420098 0.1219459831986171 0.1779402366404463 12 12 0.1219459831986171 contamination_control HBB|Macrophages +ITGA2B Macrophages 3861 0.0098420098420098 0.0068219613730323 0.0098420098420098 0.0863459350344358 0.0977057589960815 12 10 0.0863459350344358 contamination_control ITGA2B|Macrophages +KDR Macrophages 3861 0.0274540274540274 0.0178205182454308 0.0238280238280238 0.0207313249527822 0.0373895337505235 12 4 0.0207313249527822 endothelial_or_axis_marker KDR|Macrophages +MMRN2 Macrophages 3861 0.0142450142450142 0.0091695806068572 0.0121730121730121 0.0153676179654177 0.0215919491937591 12 6 0.0153676179654177 endothelial_or_axis_marker MMRN2|Macrophages +PECAM1 Macrophages 3861 0.4421134421134421 0.2537920055022898 0.2867132867132867 0.1767319409426705 0.3214946540911955 12 2 0.1767319409426705 endothelial_or_axis_marker PECAM1|Macrophages +PF4 Macrophages 3861 0.0062160062160062 0.0043086071829678 0.0062160062160062 0.1767927123740518 0.1804861804861804 12 9 0.1767927123740518 contamination_control PF4|Macrophages +PPBP Macrophages 3861 0.0106190106190106 0.0072115178083538 0.0101010101010101 0.2744240498616374 0.2763187429854096 12 8 0.2744240498616374 contamination_control PPBP|Macrophages +SELP Macrophages 3861 0.0152810152810152 0.0101144284337398 0.0137270137270137 0.0322719999185737 0.0528962316272414 12 1 0.0322719999185737 endothelial_or_axis_marker SELP|Macrophages +VWF Macrophages 3861 0.0595700595700595 0.0356794823693743 0.0435120435120435 0.0215159025864354 0.049550754423328 12 0 0.0215159025864354 endothelial_or_axis_marker VWF|Macrophages +CLEC14A Mast Cells 369 0.056910569105691 0.0394474005196716 0.056910569105691 0.0619362618635559 0.0965375192697639 5 7 0.0619362618635559 endothelial_or_axis_marker CLEC14A|Mast Cells +EMCN Mast Cells 369 0.046070460704607 0.0311539837318896 0.043360433604336 0.0445137930517 0.0683745436832682 5 3 0.0445137930517 endothelial_or_axis_marker EMCN|Mast Cells +FLT1 Mast Cells 369 0.1300813008130081 0.0847081034138615 0.1111111111111111 0.121177081865955 0.1801169590643274 5 5 0.121177081865955 endothelial_or_axis_marker FLT1|Mast Cells +GP1BA Mast Cells 369 0.032520325203252 0.0225413717255266 0.032520325203252 0.9009979886730534 1.0 5 11 0.9009979886730534 contamination_control GP1BA|Mast Cells +HBB Mast Cells 369 0.029810298102981 0.0183240454439134 0.021680216802168 0.2796454782608846 0.3919710475930755 5 12 0.2796454782608846 contamination_control HBB|Mast Cells +ITGA2B Mast Cells 369 0.05420054200542 0.0360097004506648 0.048780487804878 0.4557767313098297 0.48426435877262 5 10 0.4557767313098297 contamination_control ITGA2B|Mast Cells +KDR Mast Cells 369 0.062330623306233 0.038492873165771 0.048780487804878 0.0447803061041976 0.0765434728583093 5 4 0.0447803061041976 endothelial_or_axis_marker KDR|Mast Cells +MMRN2 Mast Cells 369 0.046070460704607 0.0287814397282205 0.037940379403794 0.0482358124326017 0.0672969625623857 5 6 0.0482358124326017 endothelial_or_axis_marker MMRN2|Mast Cells +PECAM1 Mast Cells 369 0.1409214092140921 0.0786123294884544 0.086720867208672 0.0547428968261726 0.0972410296200218 5 2 0.0547428968261726 endothelial_or_axis_marker PECAM1|Mast Cells +PF4 Mast Cells 369 0.008130081300813 0.0056353429313816 0.008130081300813 0.2312319317331349 0.2360627177700348 5 9 0.2312319317331349 contamination_control PF4|Mast Cells +PPBP Mast Cells 369 0.010840108401084 0.0075137905751755 0.010840108401084 0.2859266099382423 0.2965371875940981 5 8 0.2859266099382423 contamination_control PPBP|Mast Cells +SELP Mast Cells 369 0.040650406504065 0.0273970884443018 0.037940379403794 0.0874156005785038 0.1462009973093475 5 1 0.0874156005785038 endothelial_or_axis_marker SELP|Mast Cells +VWF Mast Cells 369 0.1084010840108401 0.064429266486136 0.08130081300813 0.0388529689719123 0.0925839444582218 5 0 0.0388529689719123 endothelial_or_axis_marker VWF|Mast Cells +CLEC14A Myeloid Cells 813 0.0959409594095941 0.063171658543608 0.084870848708487 0.0991856582276162 0.1439666009563321 2 7 0.0991856582276162 endothelial_or_axis_marker CLEC14A|Myeloid Cells +EMCN Myeloid Cells 813 0.068880688806888 0.044190650512719 0.057810578105781 0.0631409930964825 0.0911608018987485 2 3 0.0631409930964825 endothelial_or_axis_marker EMCN|Myeloid Cells +FLT1 Myeloid Cells 813 0.2164821648216482 0.1342771106539257 0.1685116851168511 0.1920867989563799 0.2731663106104744 2 5 0.1920867989563799 endothelial_or_axis_marker FLT1|Myeloid Cells +GP1BA Myeloid Cells 813 0.03690036900369 0.0237928444459297 0.031980319803198 0.9510204281985712 0.9833948339483392 2 11 0.9510204281985712 contamination_control GP1BA|Myeloid Cells +HBB Myeloid Cells 813 0.041820418204182 0.0206722753795988 0.020910209102091 0.315482099897806 0.3780495666591886 2 12 0.315482099897806 contamination_control HBB|Myeloid Cells +ITGA2B Myeloid Cells 813 0.02460024600246 0.0170515911576862 0.02460024600246 0.2158229139431324 0.2442169582986152 2 10 0.2158229139431324 contamination_control ITGA2B|Myeloid Cells +KDR Myeloid Cells 813 0.094710947109471 0.0625280568907611 0.084870848708487 0.072741401131855 0.1331743448438851 2 4 0.072741401131855 endothelial_or_axis_marker KDR|Myeloid Cells +MMRN2 Myeloid Cells 813 0.031980319803198 0.0211055110420704 0.028290282902829 0.0353714574924933 0.0501800493118053 2 6 0.0353714574924933 endothelial_or_axis_marker MMRN2|Myeloid Cells +PECAM1 Myeloid Cells 813 0.1734317343173431 0.1013956402364748 0.1180811808118081 0.0706084033917895 0.1324056823977419 2 2 0.0706084033917895 endothelial_or_axis_marker PECAM1|Myeloid Cells +PF4 Myeloid Cells 813 0.035670356703567 0.0243709546910044 0.034440344403444 1.0 1.0 2 9 1.0 contamination_control PF4|Myeloid Cells +PPBP Myeloid Cells 813 0.038130381303813 0.0250145563438513 0.033210332103321 0.9518933516907968 0.9084870848708488 2 8 0.9518933516907968 contamination_control PPBP|Myeloid Cells +SELP Myeloid Cells 813 0.051660516605166 0.0333954773400913 0.044280442804428 0.1065545966398871 0.1706320548460176 2 1 0.1065545966398871 endothelial_or_axis_marker SELP|Myeloid Cells +VWF Myeloid Cells 813 0.0971709717097171 0.0609036690351614 0.076260762607626 0.0367269176315692 0.0868444231781549 2 0 0.0367269176315692 endothelial_or_axis_marker VWF|Myeloid Cells +CLEC14A Myoepithelial Cells 8438 0.0342498222327565 0.0228118573348078 0.0311685233467646 0.0358168383941588 0.0528712323647714 8 7 0.0358168383941588 endothelial_or_axis_marker CLEC14A|Myoepithelial Cells +EMCN Myoepithelial Cells 8438 0.0362645176582128 0.023963506014734 0.0322351268073003 0.0342398120482147 0.0508311818588696 8 3 0.0342398120482147 endothelial_or_axis_marker EMCN|Myoepithelial Cells +FLT1 Myoepithelial Cells 8438 0.0977719838824366 0.0644725671229003 0.0869874377814648 0.0922296360029415 0.1410112149299534 8 5 0.0922296360029415 endothelial_or_axis_marker FLT1|Myoepithelial Cells +GP1BA Myoepithelial Cells 8438 0.020739511732638 0.0139384932042256 0.0193173737852571 0.5571335451568191 0.5940092438966579 8 11 0.5571335451568191 contamination_control GP1BA|Myoepithelial Cells +HBB Myoepithelial Cells 8438 0.0141028679781938 0.0088377982864899 0.011258592083432 0.1348747107271352 0.203551568401506 8 12 0.1348747107271352 contamination_control HBB|Myoepithelial Cells +ITGA2B Myoepithelial Cells 8438 0.020739511732638 0.0141027850223247 0.0197914197677174 0.1784997147823181 0.1964777236617758 8 10 0.1784997147823181 contamination_control ITGA2B|Myoepithelial Cells +KDR Myoepithelial Cells 8438 0.0741881962550367 0.0463084306158829 0.0597297937899976 0.0538724581366983 0.0937244799208405 8 4 0.0538724581366983 endothelial_or_axis_marker KDR|Myoepithelial Cells +MMRN2 Myoepithelial Cells 8438 0.0624555581891443 0.0397219631339557 0.0513154776013273 0.0665714148172208 0.0910211186412683 8 6 0.0665714148172208 endothelial_or_axis_marker MMRN2|Myoepithelial Cells +PECAM1 Myoepithelial Cells 8438 0.0554633799478549 0.0343003331366867 0.0438492533775776 0.0238855610846739 0.0491686336143842 8 2 0.0238855610846739 endothelial_or_axis_marker PECAM1|Myoepithelial Cells +PF4 Myoepithelial Cells 8438 0.011258592083432 0.0077356740943696 0.0110215690922019 0.3174136669018129 0.320019131141435 8 9 0.3174136669018129 contamination_control PF4|Myoepithelial Cells +PPBP Myoepithelial Cells 8438 0.014339890969424 0.0098032804643216 0.0138658449869637 0.373049890250874 0.3793078928656079 8 8 0.373049890250874 contamination_control PPBP|Myoepithelial Cells +SELP Myoepithelial Cells 8438 0.0163545863948803 0.0110974800201599 0.0155250059255747 0.035408612226895 0.0598246877132068 8 1 0.035408612226895 endothelial_or_axis_marker SELP|Myoepithelial Cells +VWF Myoepithelial Cells 8438 0.07146243185589 0.0419762066168591 0.0515525005925574 0.0253130346221518 0.0587070863739886 8 0 0.0253130346221518 endothelial_or_axis_marker VWF|Myoepithelial Cells +CLEC14A Pericytes 8087 0.3164337826140719 0.1826373823877548 0.2093483368368987 0.2867584832618149 0.3551180284975245 11 7 0.2867584832618149 endothelial_or_axis_marker CLEC14A|Pericytes +EMCN Pericytes 8087 0.3227402003215036 0.1876974327969063 0.2149128230493384 0.2681880029135547 0.3388934331646543 11 3 0.2681880029135547 endothelial_or_axis_marker EMCN|Pericytes +FLT1 Pericytes 8087 0.3560034623469766 0.2050259988814704 0.2351922839124521 0.2932948708546298 0.3812590707633433 11 5 0.2932948708546298 endothelial_or_axis_marker FLT1|Pericytes +GP1BA Pericytes 8087 0.0123655249165327 0.0083932617402912 0.011747248670706 0.3354858807392409 0.3612278966242116 11 11 0.3354858807392409 contamination_control GP1BA|Pericytes +HBB Pericytes 8087 0.0838382589340917 0.0290978152906039 0.0244837393347347 0.4440652855939436 0.4426577945969655 11 12 0.4440652855939436 contamination_control HBB|Pericytes +ITGA2B Pericytes 8087 0.0071720044515889 0.0049001078678834 0.0069246939532583 0.0620209310030028 0.0687443407779111 11 10 0.0620209310030028 contamination_control ITGA2B|Pericytes +KDR Pericytes 8087 0.6527760603437616 0.3246482093513414 0.3185359218498825 0.3776763072043215 0.4998278366145173 11 4 0.3776763072043215 endothelial_or_axis_marker KDR|Pericytes +MMRN2 Pericytes 8087 0.2594287127488562 0.1521963660737839 0.1774452825522443 0.2550711651738665 0.3147445735768315 11 6 0.2550711651738665 endothelial_or_axis_marker MMRN2|Pericytes +PECAM1 Pericytes 8087 1.07753184122666 0.5102737634871709 0.4703845678249042 0.3553369321256862 0.5274472127060166 11 2 0.3553369321256862 endothelial_or_axis_marker PECAM1|Pericytes +PF4 Pericytes 8087 0.0039569679732904 0.0027427611942522 0.0039569679732904 0.1125422138372226 0.1148933915101838 11 9 0.1125422138372226 contamination_control PF4|Pericytes +PPBP Pericytes 8087 0.0092741436873995 0.0062003416683107 0.0085322121924075 0.2359451805239446 0.2334034046411937 11 8 0.2359451805239446 contamination_control PPBP|Pericytes +SELP Pericytes 8087 0.1098058612588104 0.0635039574989391 0.0727092865092123 0.202621406109163 0.2801809145913525 11 1 0.202621406109163 endothelial_or_axis_marker SELP|Pericytes +VWF Pericytes 8087 1.29108445653518 0.522848572084377 0.4304439223445035 0.3152949033274218 0.4901820132442887 11 0 0.3152949033274218 endothelial_or_axis_marker VWF|Pericytes +CLEC14A Plasma Cells 873 0.0458190148911798 0.0306358052341192 0.0423825887743413 0.0481011988213285 0.0718936753717387 1 7 0.0481011988213285 endothelial_or_axis_marker CLEC14A|Plasma Cells +EMCN Plasma Cells 873 0.0675830469644902 0.0439389014915346 0.0584192439862542 0.06278128616698 0.0921205997691455 1 3 0.06278128616698 endothelial_or_axis_marker EMCN|Plasma Cells +FLT1 Plasma Cells 873 0.145475372279496 0.0949639526095303 0.1260022909507445 0.1358483332280187 0.2042563453306806 1 5 0.1358483332280187 endothelial_or_axis_marker FLT1|Plasma Cells +GP1BA Plasma Cells 873 0.0389461626575028 0.025018226465438 0.0320733104238258 1.0 0.986254295532646 1 11 1.0 contamination_control GP1BA|Plasma Cells +HBB Plasma Cells 873 0.0137457044673539 0.0095277962963566 0.0137457044673539 0.1454048539784621 0.2485177260512798 1 12 0.1454048539784621 contamination_control HBB|Plasma Cells +ITGA2B Plasma Cells 873 0.0240549828178694 0.0163441107895842 0.0229095074455899 0.206868296559376 0.2274322876251708 1 10 0.206868296559376 contamination_control ITGA2B|Plasma Cells +KDR Plasma Cells 873 0.0504009163802978 0.0338117373329047 0.0469644902634593 0.039334552688797 0.0736939163086014 1 4 0.039334552688797 endothelial_or_axis_marker KDR|Plasma Cells +MMRN2 Plasma Cells 873 0.0160366552119129 0.0107862296167095 0.0148911798396334 0.0180770160756215 0.0264133144666801 1 6 0.0180770160756215 endothelial_or_axis_marker MMRN2|Plasma Cells +PECAM1 Plasma Cells 873 1.7445589919816724 0.7524104298425486 0.6300114547537228 0.5239524995612319 0.7064385367047334 1 2 0.5239524995612319 endothelial_or_axis_marker PECAM1|Plasma Cells +PF4 Plasma Cells 873 0.0126002290950744 0.0087338132716602 0.0126002290950744 0.3583697636138964 0.3658566519391262 1 9 0.3583697636138964 contamination_control PF4|Plasma Cells +PPBP Plasma Cells 873 0.0286368843069874 0.0195200428883698 0.0274914089347079 0.7428074595744601 0.7520427644138984 1 8 0.7428074595744601 contamination_control PPBP|Plasma Cells +SELP Plasma Cells 873 0.0435280641466208 0.0280592409976069 0.0366552119129438 0.0895283237329889 0.1412486807583681 1 1 0.0895283237329889 endothelial_or_axis_marker SELP|Plasma Cells +VWF Plasma Cells 873 0.0847651775486827 0.051819034142692 0.0641466208476517 0.031248583687255 0.0730490503354217 1 0 0.031248583687255 endothelial_or_axis_marker VWF|Plasma Cells +CLEC14A T Lymphocytes 8018 0.0436517834871539 0.0290143268473991 0.0395360439012222 0.0455553197863865 0.0670650752565186 4 7 0.0455553197863865 endothelial_or_axis_marker CLEC14A|T Lymphocytes +EMCN T Lymphocytes 8018 0.0553754053379895 0.0361832253880223 0.048266400598653 0.0516997319099436 0.0761107037415951 4 3 0.0516997319099436 endothelial_or_axis_marker EMCN|T Lymphocytes +FLT1 T Lymphocytes 8018 0.1250935395360439 0.0823683814853259 0.110750810675979 0.1178300505401263 0.1795328930957976 4 5 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+9790.3896484375 4114.27734375 0.5612404886150851 hotspot miahfcee-1 +5857.24609375 5097.99658203125 0.5606121299946575 hotspot nacpmdne-1 +6094.7939453125 3913.425048828125 0.5600944705473929 hotspot npoadoha-1 +3642.755126953125 1291.130126953125 0.5598298916199833 hotspot fpklfbcf-1 +3638.0771484375 1303.1739501953125 0.5598298916199833 hotspot fpkolhgg-1 diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2g_hotspot_neighborhood_context.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2g_hotspot_neighborhood_context.tsv new file mode 100644 index 0000000..4c3b40b --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2g_hotspot_neighborhood_context.tsv @@ -0,0 +1,13 @@ +group neighbor_cell_type neighbor_fraction n_query_cells x y value category label +hotspot_endothelial 11q13 Invasive Tumor Cells 0.0164549653579676 433 0.0164549653579676 11q13 Invasive Tumor Cells 0.0164549653579676 hotspot_endothelial 11q13 Invasive Tumor Cells +hotspot_endothelial CAFs, Invasive Associated 0.0262702078521939 433 0.0262702078521939 CAFs, Invasive Associated 0.0262702078521939 hotspot_endothelial CAFs, Invasive Associated +all_endothelial Macrophages 0.0374681122448979 8624 0.0374681122448979 Macrophages 0.0374681122448979 all_endothelial Macrophages +hotspot_endothelial Macrophages 0.0433025404157043 433 0.0433025404157043 Macrophages 0.0433025404157043 hotspot_endothelial Macrophages +all_endothelial CAFs, Invasive Associated 0.0435557745825603 8624 0.0435557745825603 CAFs, Invasive Associated 0.0435557745825603 all_endothelial CAFs, Invasive Associated +all_endothelial T Lymphocytes 0.0666019248608534 8624 0.0666019248608534 T Lymphocytes 0.0666019248608534 all_endothelial T Lymphocytes +all_endothelial 11q13 Invasive Tumor Cells 0.0870100881261595 8624 0.0870100881261595 11q13 Invasive Tumor Cells 0.0870100881261595 all_endothelial 11q13 Invasive Tumor Cells +hotspot_endothelial CAFs, DCIS Associated 0.1579099307159353 433 0.1579099307159353 CAFs, DCIS Associated 0.1579099307159353 hotspot_endothelial CAFs, DCIS Associated +hotspot_endothelial T Lymphocytes 0.1593533487297921 433 0.1593533487297921 T Lymphocytes 0.1593533487297921 hotspot_endothelial T Lymphocytes +all_endothelial Pericytes 0.1649321660482375 8624 0.1649321660482375 Pericytes 0.1649321660482375 all_endothelial Pericytes +hotspot_endothelial Pericytes 0.1714780600461893 433 0.1714780600461893 Pericytes 0.1714780600461893 hotspot_endothelial Pericytes +all_endothelial CAFs, DCIS Associated 0.202081400742115 8624 0.202081400742115 CAFs, DCIS Associated 0.202081400742115 all_endothelial CAFs, DCIS Associated diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2h_pathway_context.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2h_pathway_context.tsv new file mode 100644 index 0000000..a360f1a --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2h_pathway_context.tsv @@ -0,0 +1,4 @@ +pathway present_genes spearman_rho_vs_vwf_selp_joint p_value x y value category label +WPB_EndothelialActivation VWF,SELP,ANGPT2,IL6,CXCL8,RAB27A,STXBP5,PLAT 0.1953464655866251 0.0 0.1953464655866251 WPB_EndothelialActivation 0.1953464655866251 pathway_correlation WPB_EndothelialActivation +Hemostasis_Thromboinflammation VWF,SELP,THBD,PLAT,SERPINE1,ADAMTS13 0.2069526148852819 0.0 0.2069526148852819 Hemostasis_Thromboinflammation 0.2069526148852819 pathway_correlation Hemostasis_Thromboinflammation +VascularIdentity PECAM1,EMCN,CDH5,KDR,FLT1,MMRN2,CLEC14A,EGFL7 0.2181908741315978 0.0 0.2181908741315978 VascularIdentity 0.2181908741315978 pathway_correlation VascularIdentity diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2i_contour_ecology_context.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2i_contour_ecology_context.tsv new file mode 100644 index 0000000..919e99e --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2i_contour_ecology_context.tsv @@ -0,0 +1,7 @@ +program mean_score max_score n_matched_exemplars hypothesis x y value category label +immune_exclusion -0.2664018102483715 0.4521304865361235 3 Outer-rim immune signals dominate the boundary while the inner rim stays comparatively immune-cold; top evidence: spp1_cd44__outer_minus_inner, immune_activation, myeloid_activation. -0.2664018102483715 immune_exclusion -0.2664018102483715 other_contour immune_exclusion +necrotic_hypoxic_rim -0.1430020149136928 0.5298084468447939 3 Hypoxia-like rim features and reduced cellularity suggest a necrotic or stressed boundary ecology; top evidence: CD3E, CXCR5, ACTA2. -0.1430020149136928 necrotic_hypoxic_rim -0.1430020149136928 other_contour necrotic_hypoxic_rim +stromal_encapsulation -0.0209864674981045 0.9994173416905704 3 Stromal matrix features wrap the contour and may form a physical barrier; top evidence: CXCL12, COL4A1, VIM. -0.0209864674981045 stromal_encapsulation -0.0209864674981045 other_contour stromal_encapsulation +emt_invasive_front 0.1117714104087119 0.9484490341559768 3 The boundary shows an EMT- and stroma-shifted invasive front relative to matched controls; top evidence: spp1_cd44__outer_minus_inner, cxcl12_cxcr4__outer_minus_inner, tgfb1_tgfbr2__outer_minus_inner. 0.1117714104087119 emt_invasive_front 0.1117714104087119 other_contour emt_invasive_front +tls_adjacent_activation 0.1461579662081422 0.9248120430631804 3 Lymphoid activation is enriched near the outer rim, consistent with TLS-adjacent immune organization; top evidence: VEGFA, KDR, TAGLN. 0.1461579662081422 tls_adjacent_activation 0.1461579662081422 other_contour tls_adjacent_activation +myeloid_vascular_belt 0.1625034299556274 0.5726395582270783 3 Myeloid and vascular programs co-accumulate along the contour edge, consistent with a perivascular suppressive belt; top evidence: TAGLN, SLC2A1, VEGFA. 0.1625034299556274 myeloid_vascular_belt 0.1625034299556274 vascular_contour myeloid_vascular_belt diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2j_cross_method_consensus.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2j_cross_method_consensus.tsv new file mode 100644 index 0000000..f2322b0 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/figures/panels/source_data/fig2j_cross_method_consensus.tsv @@ -0,0 +1,36 @@ +axis_id method exact_support same_lr_any_celltype_support same_sender_receiver_support exact_best_rank same_lr_best_rank 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2 exact CD48-CD2|T Lymphocytes->T Lymphocytes|cellphonedb +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells cellphonedb True True True 2782.0 1232.0 0.9989598261363328 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/cellphonedb/cellphonedb_standardized.tsv.gz JAG1-NOTCH2 2 cellphonedb JAG1-NOTCH2 2 exact JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells|cellphonedb +VWF-SELP|Endothelial Cells->Endothelial Cells laris True True True 2845.0 2845.0 0.9978205811017408 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz VWF-SELP 2 laris VWF-SELP 2 exact VWF-SELP|Endothelial Cells->Endothelial Cells|laris +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated laris True True True 18.0 18.0 0.9999869725311988 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz VWF-LRP1 2 laris VWF-LRP1 2 exact VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated|laris +MMRN2-CD93|Endothelial Cells->Endothelial Cells laris True True True 5577.0 5577.0 0.99572699023323 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz MMRN2-CD93 2 laris MMRN2-CD93 2 exact MMRN2-CD93|Endothelial Cells->Endothelial Cells|laris +DLL4-NOTCH3|Endothelial Cells->Pericytes laris True True True 9878.0 9878.0 0.9924310406265446 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz DLL4-NOTCH3 2 laris DLL4-NOTCH3 2 exact DLL4-NOTCH3|Endothelial Cells->Pericytes|laris +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes laris True True True 226.0 226.0 0.9998275776188086 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz CXCL12-CXCR4 2 laris CXCL12-CXCR4 2 exact CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes|laris +CD48-CD2|T Lymphocytes->T Lymphocytes laris True True True 15762.0 15762.0 0.987922003777966 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz CD48-CD2 2 laris CD48-CD2 2 exact CD48-CD2|T Lymphocytes->T Lymphocytes|laris +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells laris True True True 2153.0 889.0 0.9993195063355648 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/laris/laris_standardized.tsv.gz JAG1-NOTCH2 2 laris JAG1-NOTCH2 2 exact JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells|laris +VWF-SELP|Endothelial Cells->Endothelial Cells liana True True True 8450.0 1616.0 0.9978299106836924 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz VWF-SELP 2 liana VWF-SELP 2 exact VWF-SELP|Endothelial Cells->Endothelial Cells|liana +VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated liana True True True 58588.0 3227.0 0.9956651962016048 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz VWF-LRP1 2 liana VWF-LRP1 2 exact VWF-LRP1|Endothelial Cells->CAFs, DCIS Associated|liana +MMRN2-CD93|Endothelial Cells->Endothelial Cells liana True True True 6324.0 3314.0 0.9955482935573206 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz MMRN2-CD93 2 liana MMRN2-CD93 2 exact MMRN2-CD93|Endothelial Cells->Endothelial Cells|liana +DLL4-NOTCH3|Endothelial Cells->Pericytes liana True True True 81639.0 32868.0 0.955836330923168 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz DLL4-NOTCH3 2 liana DLL4-NOTCH3 2 exact DLL4-NOTCH3|Endothelial Cells->Pericytes|liana +CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes liana True True True 69984.0 9542.0 0.9871796766768476 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz CXCL12-CXCR4 2 liana CXCL12-CXCR4 2 exact CXCL12-CXCR4|CAFs, DCIS Associated->T Lymphocytes|liana +CD48-CD2|T Lymphocytes->T Lymphocytes liana True True True 23050.0 23050.0 0.9690288615160526 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz CD48-CD2 2 liana CD48-CD2 2 exact CD48-CD2|T Lymphocytes->T Lymphocytes|liana +JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells liana True True True 1437.0 170.0 0.9997729132542068 /cfs/klemming/scratch/h/hutaobo/topolink_cci_benchmark_2026-04/runs/full_common/liana/liana_standardized.tsv.gz JAG1-NOTCH2 2 liana JAG1-NOTCH2 2 exact JAG1-NOTCH2|11q13 Invasive Tumor Cells->11q13 Invasive Tumor Cells|liana +VWF-SELP|Endothelial Cells->Endothelial Cells spatialdm True True True 1967.0 1896.0 0.9957513401775244 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b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/online_methods.md @@ -0,0 +1,89 @@ +# Online Methods Draft + +## Method Overview + +TopoLink-CCI is a topology-guided spatial cell-cell interaction scoring framework implemented in pyXenium. In the analysis reported here, TopoLink-CCI was run in cell-cell interaction-resource mode, where each candidate consists of a ligand or interaction-source gene, a receptor or interaction-target gene, a sender cell group and a receiver cell group. The method ranks candidate molecular interaction axes by combining tissue topology, sender and receiver expression support, sender-receiver structural compatibility and local spatial contact. + +## Dataset + +The primary dataset was the Atera Xenium WTA FFPE breast cancer dataset. The full benchmark object contained 170,057 cells, 18,028 RNA features and 20 annotated cell groups. Gene symbols were taken from the Xenium feature metadata. Spatial coordinates were taken from the cell-level Xenium output. The main benchmark used a common interaction resource containing 3,299 cell-cell interaction or molecular interaction pairs to support cross-method comparison. + +## Topology Inputs + +TopoLink-CCI uses pyXenium topology outputs that encode gene-to-cell-type anchoring and cell-type-to-cell-type structural relationships. For a ligand or source gene \(l\), receptor or target gene \(r\), sender cell group \(s\) and receiver cell group \(t\), the topology maps provide ligand-sender distance, receptor-receiver distance and sender-receiver structure distance. These distances are converted into support scores by subtracting each distance from 1 after normalization. + +## Expression Support + +For each gene and cell group, expression support combines pseudobulk expression share and detection fraction. If \(P(g,c)\) is the fraction of total gene expression assigned to cell group \(c\), and \(F(g,c)\) is the fraction of cells in group \(c\) in which gene \(g\) is detected, the expression support is: + +\[ +E(g,c) = \mathrm{rowNorm}\left(P(g,c)\sqrt{F(g,c)}\right) +\] + +This favors genes that are both abundant and recurrently detected in the relevant cell group, while preserving cell-type specificity. + +## Local Contact Support + +Local contact support is computed from a cell-cell spatial neighbor graph. In the full benchmark, spatial neighborhoods were constructed from cell coordinates using the configured pyXenium neighbor settings. For each sender-receiver group pair and each candidate gene pair, TopoLink-CCI computes local edge strength from normalized source-gene expression in sender cells and normalized target-gene expression in receiver cells. It also records active-edge coverage, local edge count and an edge-count support term. Candidate contacts with insufficient sender-receiver edges are assigned zero contact support. + +## TopoLink-CCI Score + +For candidate \((l,r,s,t)\), the final score is: + +\[ +\mathrm{TopoLink\mbox{-}CCI}_{l,r,s,t} += +\pi_{l,r} +\times +\mathrm{GM} +\left[ +A_{\mathrm{sender}}, +A_{\mathrm{receiver}}, +B_{\mathrm{structure}}, +E_{\mathrm{sender}}, +E_{\mathrm{receiver}}, +C_{\mathrm{local}} +\right] +\] + +where \(A_{\mathrm{sender}}\) is ligand-sender topology support, \(A_{\mathrm{receiver}}\) is receptor-receiver topology support, \(B_{\mathrm{structure}}\) is sender-receiver structural support, \(E_{\mathrm{sender}}\) and \(E_{\mathrm{receiver}}\) are expression support terms, \(C_{\mathrm{local}}\) is local contact support and \(\pi_{l,r}\) is the optional prior confidence assigned to the molecular interaction pair. The geometric mean ensures that a high score requires broad support across topology, expression and contact components. + +## Benchmarking + +The full common-database TopoLink-CCI run generated 1,319,600 sender-receiver candidate axes. Standardized benchmark outputs were compared with completed full or bounded method outputs from CellPhoneDB, LIANA+, SpatialDM, stLearn, LARIS and related adapters. Raw scores were not compared directly across methods. Instead, each method was normalized within method and interpreted through rank, theme recovery, canonical axis recovery and output provenance. + +## False-Positive Controls + +Seven biologically interpretable TopoLink-CCI axes were selected for targeted computational validation: VWF-SELP, VWF-LRP1, MMRN2-CD93, CD48-CD2, DLL4-NOTCH3, CXCL12-CXCR4 and JAG1-NOTCH2. The validation framework implemented the main computational principles used in classical cell-cell interaction and cell-cell communication methods: + +- Cell-label permutation of sender-receiver communication probability. +- Group specificity checks analogous to CellChat-style cell-group communication scoring. +- Spatial-neighborhood coupling and spatial null controls inspired by spatial CCC methods. +- Matched-expression random gene-pair negative controls. +- Receiver target and pathway support inspired by ligand-target frameworks. +- Received-signal association with receiver target programs. +- Cross-method consensus across benchmarked methods. +- TopoLink-CCI component ablation. +- Stratified bootstrap stability. + +Candidate axes were assigned an evidence class based on the number and type of independent evidence layers. `strong` required at least five independent support layers and no contamination or label-artifact flag. `moderate` indicated three to four support layers. `hypothesis_only` indicated limited support outside TopoLink-CCI score. `artifact_risk` indicated failed null controls or contamination risk. + +## Lead Biological Axis + +The lead axis, VWF-SELP from endothelial cells to endothelial cells, had a TopoLink-CCI score of 0.791289 and rank 1 among all full common-database candidates. Its component values were: sender anchor 0.955713, receiver anchor 0.881913, structure bridge 1.000000, sender expression 1.000000, receiver expression 1.000000, local contact 0.291245 and prior confidence 1.000000. This axis was interpreted as an endothelial activation and vascular adhesion niche. The interpretation is RNA-level and spatially supported; it does not prove protein-level VWF secretion, P-selectin surface presentation or platelet or leukocyte adhesion. + +## Reproducibility + +Primary outputs used for the manuscript are stored under: + +`benchmarking/cci_2026_atera/pdc_collected/pdc_20260426_1327/` + +Validation outputs used for false-positive control summaries are stored under: + +`benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/` + +The figure drafts in this manuscript package are regenerated by: + +```bash +python benchmarking/cci_2026_atera/topolink_cci_short_communication/scripts/make_topolink_cci_nature_brief_figures.py +``` diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/presubmission_inquiry.md b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/presubmission_inquiry.md new file mode 100644 index 0000000..4018d5b --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/presubmission_inquiry.md @@ -0,0 +1,21 @@ +# Presubmission Inquiry Draft + +**Target:** Nature Methods +**Article type requested:** Brief Communication +**Proposed title:** Topology-guided inference of spatial cell-cell interaction axes + +Dear Nature Methods editors, + +We would like to ask whether the manuscript described below would be suitable for consideration as a Brief Communication. + +Spatial cell-cell interaction and cell-cell communication analysis in spatial transcriptomics is highly susceptible to false positives from co-expression, cell-type abundance, database ambiguity and spatial proximity confounding. We developed **TopoLink-CCI**, a topology-guided spatial cell-cell interaction framework that ranks molecular interaction axes by integrating tissue topology, sender and receiver expression specificity, sender-receiver structural bridging and local spatial contact. We then evaluate candidate axes with orthogonal computational false-positive controls adapted from classical cell-cell communication methods, including cell-label permutation, spatial nulls, matched-gene controls, downstream target support, cross-method consensus, component ablation and bootstrap stability. + +Applied to a 170,057-cell Xenium WTA breast cancer dataset, TopoLink-CCI generated 1,319,600 sender-receiver interaction hypotheses and prioritized interpretable vascular, stromal, immune and Notch axes. Seven representative axes, including VWF-SELP, VWF-LRP1, MMRN2-CD93, DLL4-NOTCH3, CXCL12-CXCR4, CD48-CD2 and JAG1-NOTCH2, received strong computational support under independent false-positive controls. The top-ranked VWF-SELP endothelial-endothelial axis was interpreted as a topology-supported endothelial activation and vascular adhesion niche, while explicitly avoiding claims of protein-level signaling or causality. + +We believe this work fits Nature Methods because it introduces a concise computational method for a current spatial omics bottleneck: how to prioritize cell-cell interaction hypotheses without treating co-expression or database membership as proof of communication. The manuscript is planned as a Brief Communication with two main figures, an Online Methods section, reproducible code and supplementary validation tables. + +Thank you for considering this presubmission inquiry. + +Sincerely, + +[Authors] diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/supplementary_data_manifest.tsv b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/supplementary_data_manifest.tsv new file mode 100644 index 0000000..03571de --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/supplementary_data_manifest.tsv @@ -0,0 +1,10 @@ +supplementary_item source_path description +Supplementary Data 1 benchmarking/cci_2026_atera/pdc_collected/pdc_20260426_1327/runs/full_common/pyxenium/pyxenium_scores.tsv Full TopoLink-CCI full-common score table with 1,319,600 candidate axes. +Supplementary Data 2 benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_evidence.tsv Validation evidence table for seven representative TopoLink-CCI axes. +Supplementary Data 3 benchmarking/cci_2026_atera/pdc_validation_v2_collected/topolink_cci_validation_v2/tables/topolink_cci_validation_v2_false_positive_controls.tsv False-positive control summary table. +Supplementary Data 4 benchmarking/cci_2026_atera/vwf_selp_deep_dive/tables/vascular_top_hits_compact.tsv Top vascular and endothelial interaction axes used for biological interpretation. +Supplementary Data 5 benchmarking/cci_2026_atera/vwf_selp_deep_dive/tables/component_decomposition.tsv VWF-SELP component decomposition. +Supplementary Data 6 benchmarking/cci_2026_atera/vwf_selp_deep_dive/tables/cross_method_vascular_consensus_compact.tsv Cross-method support table for vascular axes. +Supplementary Software 1 benchmarking/cci_2026_atera/scripts/topolink_cci_validation_v2.py Validation framework script. +Supplementary Software 2 benchmarking/cci_2026_atera/topolink_cci_short_communication/scripts/make_topolink_cci_nature_brief_figures.py Figure-generation script for the Brief Communication draft. + diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/supplementary_information_outline.md b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/supplementary_information_outline.md new file mode 100644 index 0000000..28aaa55 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/supplementary_information_outline.md @@ -0,0 +1,75 @@ +# Supplementary Information Outline + +## Supplementary Note 1. TopoLink-CCI algorithm + +- Definition of molecular interaction axis. +- Topology anchor construction. +- Expression support calculation. +- Local contact graph construction. +- Prior-weighted geometric mean score. +- Interpretation of component diagnostics. + +## Supplementary Note 2. Dataset and preprocessing + +- Atera Xenium WTA breast cancer source data. +- Cell group annotation. +- Gene-symbol handling. +- Full sparse bundle and common interaction resource. +- PDC execution and reproducibility paths. + +## Supplementary Note 3. Benchmarking against existing methods + +- Completed full or bounded methods. +- Method-specific environment isolation. +- Unified output schema. +- Common-database versus native-database interpretation. +- Why raw scores are not compared directly. + +## Supplementary Note 4. False-positive control framework + +- Cell-label permutation. +- Group specificity. +- Spatial null. +- Matched-expression random gene-pair controls. +- Receiver target support. +- Received-signal association. +- Cross-method consensus. +- Component ablation. +- Stratified bootstrap stability. + +## Supplementary Note 5. Biological interpretation + +- VWF-SELP endothelial activation and vascular adhesion niche. +- VWF-LRP1 vascular-stromal matrix/scavenger axis. +- MMRN2-CD93 angiogenic endothelial matrix axis. +- DLL4-NOTCH3 endothelial-pericyte Notch axis. +- CXCL12-CXCR4 CAF-to-T-cell chemokine axis. +- CD48-CD2 T-cell adhesion/co-stimulation axis. +- JAG1-NOTCH2 tumor-intrinsic Notch axis. +- Caveats separating RNA-level spatial evidence from protein-level function. + +## Supplementary Figures + +- Supplementary Fig. 1: Full false-positive control null distributions. +- Supplementary Fig. 2: Per-axis validation cards. +- Supplementary Fig. 3: Runtime, memory and engineering reproducibility summary. +- Supplementary Fig. 4: Extended VWF-SELP deep-dive, including expression specificity, spatial hotspot and contour context. + +## Supplementary Tables + +- Supplementary Table 1: Full TopoLink-CCI score schema and component definitions. +- Supplementary Table 2: Top interpretable axes and biological categories. +- Supplementary Table 3: Benchmark method run status, environment and resource use. +- Supplementary Table 4: Validation evidence table for seven representative axes. +- Supplementary Table 5: False-positive control summaries. +- Supplementary Table 6: Cross-method consensus. +- Supplementary Table 7: Component ablation and bootstrap stability. +- Supplementary Table 8: Method cards for failed or bounded benchmark methods. + +## Supplementary Data Files + +- Supplementary Data 1: Full or indexed TopoLink-CCI standardized output. +- Supplementary Data 2: Validation evidence table. +- Supplementary Data 3: Benchmark combined standardized results. +- Supplementary Data 4: Canonical axes and pathway categories. +- Supplementary Software 1: Reproducible scripts and environment manifests. diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/topolink_cci_brief_communication.md b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/topolink_cci_brief_communication.md new file mode 100644 index 0000000..2f92b94 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/manuscript/topolink_cci_brief_communication.md @@ -0,0 +1,50 @@ +# Topology-guided inference of spatial cell-cell interaction axes + +**Target format:** Nature Methods Brief Communication +**Method name:** TopoLink-CCI +**Short title:** TopoLink-CCI for spatial interaction discovery +**Primary dataset:** Atera Xenium WTA FFPE breast cancer +**Status:** Draft for presubmission and coauthor iteration + +## Abstract + +Spatial cell-cell interaction inference is confounded by co-expression, cell abundance and incomplete cell-cell interaction databases. We introduce TopoLink-CCI, a topology-guided framework that integrates tissue topology, expression specificity and local spatial contact, then evaluates candidates with orthogonal false-positive controls. In Xenium WTA breast cancer, TopoLink-CCI prioritizes vascular, stromal, immune and Notch interaction axes, including an endothelial VWF-SELP activation niche. + +## Main Text Draft + +Spatial transcriptomics enables cell-cell interaction and cell-cell communication analysis in intact tissue, but inference remains vulnerable to false positives. Genes with strong cell-type specificity can appear as communication signals even when no local contact exists; abundant cell types can dominate sender-receiver summaries; curated cell-cell interaction resources mix secreted, membrane, extracellular-matrix and adhesion biology; and spatial proximity alone does not prove signaling. These problems are amplified in imaging-based whole-transcriptome platforms, where single-cell resolution encourages cell-pair interpretation while RNA measurements do not directly observe protein release, binding or pathway activation. Existing tools reduce parts of this problem through curated resources, expression thresholds, group-label permutations, spatial neighborhoods, downstream target models or consensus rankings, but no single control is sufficient for high-resolution tissue-scale data. We therefore reasoned that spatial interaction discovery should be framed as hypothesis prioritization: candidate molecular axes should be ranked by concordant topology, expression and local contact, and then challenged with independent false-positive controls before being interpreted biologically. + +We developed TopoLink-CCI, a topology-guided spatial cell-cell interaction framework implemented in pyXenium. The method starts from a topology map that relates genes to cell groups and cell groups to tissue structures. In cell-cell interaction-resource mode, TopoLink-CCI evaluates each ligand, receptor, sender and receiver combination with six components: ligand-to-sender topology anchoring, receptor-to-receiver topology anchoring, sender-receiver structure bridging, ligand expression support in the sender, receptor expression support in the receiver and local contact support between neighboring sender and receiver cells. The final score is a prior-weighted geometric mean of these components, so a candidate cannot be ranked highly by expression alone if topology or contact support is missing. Local contact is calculated on a cell-cell neighbor graph and combines edge strength, active-edge coverage and sender-receiver edge support. TopoLink-CCI retains every component as a diagnostic field, allowing users to distinguish topology-driven, expression-driven and contact-driven axes. This diagnostic design is important because spatial molecular interaction resources often contain a mixture of paracrine signaling, juxtacrine signaling, extracellular-matrix binding, adhesion, scavenger-receptor biology and shared activation states. We use the term interaction axis rather than classical cell-cell interaction interaction because these relationships are biologically interpretable but not always simple secreted cell-cell interaction events. + +We applied TopoLink-CCI to the Atera Xenium WTA breast cancer dataset containing 170,057 cells, 18,028 RNA features and 20 annotated cell groups. Using a common interaction resource of 3,299 pairs, the full run generated 1,319,600 sender-receiver hypotheses. We compared the output with completed full or bounded runs from CellPhoneDB, LIANA+, SpatialDM, stLearn, LARIS and related benchmark adapters, and then evaluated seven interpretable axes with false-positive controls inspired by established cell-cell communication methods. These controls included cell-label permutation, group specificity, spatial nulls, spatial-neighborhood coupling, matched-expression random gene pairs, receiver target support, received-signal association, cross-method consensus, component ablation and stratified bootstrap stability. All seven candidate axes were classified as strongly supported computational hypotheses: VWF-SELP, VWF-LRP1, MMRN2-CD93, CD48-CD2, DLL4-NOTCH3, CXCL12-CXCR4 and JAG1-NOTCH2. Each had significant cell-label permutation support, at least six independent evidence layers and no contamination flag. Five axes were recovered by same-pair support across benchmarked methods, and all seven remained stable under stratified bootstrap. Importantly, the evidence framework preserves caveats rather than forcing every axis through the same gate; for example, CXCL12-CXCR4 had weak spatial-null support but strong expression, permutation, downstream, consensus and bootstrap support. This makes the validation table more useful than a binary pass-fail filter, because different biological mechanisms can have different expected spatial signatures. + +The top-ranked axis was VWF-SELP from endothelial cells to endothelial cells. This result was not driven by a single score component: VWF and SELP were strongly anchored to endothelial topology, both showed maximal expression support in the relevant population, the sender-receiver structure bridge was maximal, and 12,779 endothelial-endothelial local edges contributed measurable contact support. Component ablation retained the vascular theme but showed that local contact was important for the top-hit rank. Spatial hotspot analysis, endothelial marker specificity and contamination controls supported an endothelial origin rather than a platelet or erythroid artifact. We interpret this axis as an endothelial activation and vascular adhesion niche consistent with Weibel-Palade body biology, rather than as proof of protein-level VWF release or P-selectin-mediated adhesion. Other high-ranking axes recovered vascular-stromal matrix biology (VWF-LRP1), angiogenic endothelial matrix biology (MMRN2-CD93), endothelial-pericyte Notch signaling (DLL4-NOTCH3), CAF-to-T-cell chemokine recruitment (CXCL12-CXCR4), T-cell adhesion and co-stimulation (CD48-CD2) and tumor-intrinsic Notch signaling (JAG1-NOTCH2). These axes span the biological contexts in which spatial information is expected to matter: vascular neighborhoods, stromal boundaries, immune niches and tumor-intrinsic programs. Together, these results suggest that topology-guided scoring can prioritize spatial molecular interaction hypotheses that are both computationally robust and biologically interpretable. TopoLink-CCI is therefore best viewed as a discovery and validation framework: it narrows the search space to axes compatible with tissue topology, local organization and independent controls, while leaving causal signaling and protein-level mechanism to orthogonal experimental validation. + +## Figure Legends + +### Figure 1 | TopoLink-CCI method and validation logic. + +**a,** TopoLink-CCI links sender and receiver cells through topology anchors, tissue-structure bridging and local spatial contact. **b,** The discovery score is a prior-weighted geometric mean of sender anchor, receiver anchor, structure bridge, sender expression, receiver expression and local contact. **c,** Workflow from Xenium WTA data and pyXenium topology maps to candidate interaction axes and orthogonal false-positive controls. **d,** Evidence matrix for seven interpretable axes. Orange marks indicate axis-specific weak evidence layers rather than artifact risk. + +### Figure 2 | Whole-dataset discovery and biological interpretation. + +**a,** Top interpretable TopoLink-CCI axes ranked by discovery score. **b,** Component decomposition for the lead VWF-SELP endothelial-endothelial axis. **c,** Spatial hotspot overlay for VWF-SELP endothelial neighborhoods. **d,** Validation and cross-method support counts show that candidates are not supported solely by TopoLink-CCI. **e,** WTA expression specificity supports endothelial identity for the VWF-SELP interpretation. **f,** Biological model: TopoLink-CCI prioritizes a topology-supported endothelial activation niche, which remains a computational hypothesis requiring protein-level or functional validation. + +## Key Claims + +- TopoLink-CCI prioritizes spatially supported molecular interaction axes by combining tissue topology, expression and local contact. +- The TopoLink-CCI score is a discovery score, not a direct proof of protein-level signaling. +- In the Atera Xenium WTA breast cancer dataset, seven interpretable axes received strong computational support under orthogonal false-positive controls. +- VWF-SELP is best described as a topology-supported endothelial activation and vascular adhesion niche, not as direct evidence of VWF/P-selectin protein release. + +## Recommended References + +1. Efremova M, et al. CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit cell-cell interaction complexes. *Nature Protocols*. 2020. +2. Jin S, et al. Inference and analysis of cell-cell communication using CellChat. *Nature Communications*. 2021. +3. Browaeys R, et al. NicheNet: modeling intercellular communication by linking ligands to target genes. *Nature Methods*. 2020. +4. Dimitrov D, et al. Comparison of methods and resources for cell-cell communication inference from single-cell RNA-seq data. *Nature Communications*. 2022. +5. Palla G, et al. Squidpy: a scalable framework for spatial omics analysis. *Nature Methods*. 2022. +6. Pham D, et al. stLearn: integrating spatial location, tissue morphology and gene expression to find cell-cell interactions. *Nature Communications*. 2023. +7. Li H, et al. SpatialDM for spatially resolved transcriptomics cell-cell interaction inference. *Nature Communications*. 2023. +8. Cang Z, et al. Screening cell-cell communication in spatial transcriptomics via collective optimal transport. *Nature Methods*. 2023. +9. Shao X, et al. SpaTalk: inferring spatially resolved cell-cell communication. *Nature Communications*. 2022. diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/scripts/make_topolink_cci_nature_brief_figures.py b/benchmarking/cci_2026_atera/topolink_cci_short_communication/scripts/make_topolink_cci_nature_brief_figures.py new file mode 100644 index 0000000..8b0e3a6 --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/scripts/make_topolink_cci_nature_brief_figures.py @@ -0,0 +1,337 @@ +"""Create draft Nature Methods Brief Communication figures for TopoLink-CCI. + +The script uses the PDC-clean TopoLink-CCI validation outputs plus the +VWF-SELP deep-dive artifacts. It is intentionally self-contained so the +manuscript figure drafts can be regenerated after validation table updates. +""" + +from __future__ import annotations + +from pathlib import Path + +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +from matplotlib import patches + + +ROOT = Path(__file__).resolve().parents[2] +VALIDATION = ROOT / "pdc_validation_v2_collected" / "topolink_cci_validation_v2" +DEEP_DIVE = ROOT / "vwf_selp_deep_dive" +OUT = ROOT / "topolink_cci_short_communication" / "figures" + + +COLORS = { + "vascular": "#0f766e", + "stromal": "#8a5a2b", + "immune": "#3f7f3f", + "notch": "#5b5f97", + "tumor": "#7a7a7a", + "pass": "#138a72", + "partial": "#e69f00", + "fail": "#b23a48", + "blue": "#2563eb", + "light": "#f4f7f6", + "text": "#1f2933", +} + + +BIOLOGY_THEME = { + "VWF-SELP": "vascular", + "VWF-LRP1": "vascular", + "MMRN2-CD93": "vascular", + "CD48-CD2": "immune", + "DLL4-NOTCH3": "notch", + "CXCL12-CXCR4": "stromal", + "JAG1-NOTCH2": "tumor", +} + + +def load_evidence() -> pd.DataFrame: + path = VALIDATION / "tables" / "topolink_cci_validation_v2_evidence.tsv" + df = pd.read_csv(path, sep="\t") + df["pair"] = df["ligand"] + "-" + df["receptor"] + df["short_axis"] = df["pair"] + "\n" + df["sender"].str.replace(" Cells", "", regex=False) + " -> " + df["receiver"].str.replace(" Cells", "", regex=False) + df["theme"] = df["pair"].map(BIOLOGY_THEME).fillna("tumor") + return df.sort_values("pyxenium_rank") + + +def add_panel_label(ax, label: str) -> None: + ax.text( + -0.06, + 1.05, + label, + transform=ax.transAxes, + fontsize=16, + fontweight="bold", + va="top", + ha="left", + color=COLORS["text"], + ) + + +def rounded_box(ax, xy, width, height, text, fc="#ffffff", ec="#425466", fontsize=9): + box = patches.FancyBboxPatch( + xy, + width, + height, + boxstyle="round,pad=0.03,rounding_size=0.04", + fc=fc, + ec=ec, + lw=1.2, + ) + ax.add_patch(box) + ax.text( + xy[0] + width / 2, + xy[1] + height / 2, + text, + ha="center", + va="center", + fontsize=fontsize, + color=COLORS["text"], + wrap=True, + ) + return box + + +def draw_figure_1(evidence: pd.DataFrame) -> plt.Figure: + fig = plt.figure(figsize=(14, 9), constrained_layout=True) + gs = fig.add_gridspec(2, 2, width_ratios=[1.05, 1.2], height_ratios=[1, 1.15]) + + # A. Conceptual topology/contact model. + ax = fig.add_subplot(gs[0, 0]) + ax.set_axis_off() + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + add_panel_label(ax, "a") + ax.set_title("TopoLink-CCI links topology, expression and contact", fontsize=12, fontweight="bold", loc="left") + for x, y, color, label in [ + (0.26, 0.55, COLORS["vascular"], "sender\ncell"), + (0.64, 0.55, COLORS["notch"], "receiver\ncell"), + (0.45, 0.25, COLORS["blue"], "local\nneighbor graph"), + ]: + circ = patches.Circle((x, y), 0.12, fc=color, ec="white", lw=2, alpha=0.9) + ax.add_patch(circ) + ax.text(x, y, label, ha="center", va="center", color="white", fontsize=9, fontweight="bold") + ax.annotate("", xy=(0.52, 0.55), xytext=(0.38, 0.55), arrowprops=dict(arrowstyle="->", lw=2.5, color=COLORS["text"])) + ax.text(0.45, 0.61, "molecular\ninteraction axis", ha="center", fontsize=9) + rounded_box(ax, (0.05, 0.78), 0.35, 0.13, "ligand-sender\ntopology anchor", fc="#e0f2f1", ec=COLORS["vascular"]) + rounded_box(ax, (0.58, 0.78), 0.35, 0.13, "receptor-receiver\ntopology anchor", fc="#ebe9fb", ec=COLORS["notch"]) + rounded_box(ax, (0.25, 0.03), 0.43, 0.13, "structure bridge +\nspatial local contact", fc="#eff6ff", ec=COLORS["blue"]) + ax.plot([0.22, 0.26], [0.78, 0.67], color=COLORS["vascular"], lw=1.5) + ax.plot([0.74, 0.64], [0.78, 0.67], color=COLORS["notch"], lw=1.5) + ax.plot([0.46, 0.45], [0.16, 0.36], color=COLORS["blue"], lw=1.5) + + # B. Score formula. + ax = fig.add_subplot(gs[0, 1]) + ax.set_axis_off() + add_panel_label(ax, "b") + ax.set_title("Discovery score uses a prior-weighted geometric mean", fontsize=12, fontweight="bold", loc="left") + formula = ( + r"$\mathrm{TopoLink\!-\!CCI}_{l,r,s,t} = \pi_{l,r} \times$" "\n" + r"$\mathrm{GM}(A_\mathrm{sender}, A_\mathrm{receiver}, B_\mathrm{structure},$" "\n" + r"$E_\mathrm{sender}, E_\mathrm{receiver}, C_\mathrm{local})$" + ) + ax.text(0.5, 0.74, formula, ha="center", va="center", fontsize=18, color=COLORS["text"]) + components = [ + ("sender anchor", COLORS["vascular"]), + ("receiver anchor", COLORS["notch"]), + ("structure bridge", COLORS["blue"]), + ("sender expression", "#2f855a"), + ("receiver expression", "#2f855a"), + ("local contact", "#c2410c"), + ] + for i, (name, color) in enumerate(components): + x = 0.08 + (i % 3) * 0.3 + y = 0.34 - (i // 3) * 0.18 + rounded_box(ax, (x, y), 0.23, 0.12, name, fc="#ffffff", ec=color, fontsize=9) + ax.text(0.5, 0.05, "High scores are hypotheses; validation gates test false-positive risk.", ha="center", fontsize=10, color="#4b5563") + + # C. Workflow. + ax = fig.add_subplot(gs[1, 0]) + ax.set_axis_off() + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + add_panel_label(ax, "c") + ax.set_title("Brief Communication workflow", fontsize=12, fontweight="bold", loc="left") + steps = [ + ("Xenium WTA\ncells + genes + xy", "#e8f5e9"), + ("pyXenium\ntopology map", "#e0f2f1"), + ("TopoLink-CCI\ncandidate axes", "#eff6ff"), + ("orthogonal\nfalse-positive controls", "#fff7ed"), + ("evidence class\nstrong / moderate / risk", "#f4f7f6"), + ] + ys = np.linspace(0.78, 0.22, len(steps)) + for i, (text, fc) in enumerate(steps): + rounded_box(ax, (0.2, ys[i]), 0.6, 0.11, text, fc=fc, ec="#425466", fontsize=8.5) + if i < len(steps) - 1: + ax.annotate( + "", + xy=(0.5, ys[i + 1] + 0.12), + xytext=(0.5, ys[i]), + arrowprops=dict(arrowstyle="->", lw=1.6, color=COLORS["text"]), + ) + ax.text( + 0.5, + 0.06, + "Primary dataset: Atera Xenium WTA breast cancer\n170,057 cells; 20 cell groups; 3,299 common interaction pairs", + ha="center", + fontsize=9, + ) + + # D. Evidence matrix. + ax = fig.add_subplot(gs[1, 1]) + add_panel_label(ax, "d") + layers = [ + ("expression", "expression_specificity_support"), + ("label\nperm.", "cell_label_permutation_support"), + ("spatial\nnull", "spatial_null_support"), + ("matched\ngenes", "matched_gene_control_support"), + ("downstream", "downstream_target_support"), + ("received\nsignal", "functional_received_signal_support"), + ("cross\nmethod", "cross_method_support"), + ("ablation", "component_ablation_support"), + ("bootstrap", "bootstrap_stability_support"), + ] + matrix = evidence[[col for _, col in layers]].astype(bool).to_numpy() + n_rows, n_cols = matrix.shape + ax.set_xlim(-0.5, n_cols - 0.5) + ax.set_ylim(n_rows - 0.5, -0.5) + ax.set_xticks(range(n_cols)) + ax.set_xticklabels([x for x, _ in layers], fontsize=8) + ax.set_yticks(range(n_rows)) + ax.set_yticklabels(evidence["pair"].tolist(), fontsize=9) + ax.set_title("Orthogonal evidence matrix (7/7 strong)", fontsize=12, fontweight="bold", loc="left") + for i in range(n_rows): + for j in range(n_cols): + color = COLORS["pass"] if matrix[i, j] else COLORS["partial"] + marker = "o" if matrix[i, j] else "X" + ax.scatter(j, i, s=230, marker=marker, color=color, edgecolor="white", linewidth=1.4) + ax.grid(True, color="#e5e7eb", lw=0.8) + ax.tick_params(length=0) + ax.text(0.99, -0.16, "orange = weak/axis-specific caveat, not artifact risk", transform=ax.transAxes, ha="right", fontsize=8, color="#6b7280") + + fig.suptitle("Figure 1 | TopoLink-CCI method and validation logic", fontsize=16, fontweight="bold") + return fig + + +def draw_figure_2(evidence: pd.DataFrame) -> plt.Figure: + fig = plt.figure(figsize=(15, 10), constrained_layout=True) + gs = fig.add_gridspec(2, 3, width_ratios=[1.1, 1, 1.15], height_ratios=[1, 1]) + + # A. Ranked interpretable axes. + ax = fig.add_subplot(gs[0, 0]) + add_panel_label(ax, "a") + plot_df = evidence.sort_values("CCI_score", ascending=True) + bar_colors = [COLORS.get(BIOLOGY_THEME.get(pair, "tumor"), COLORS["tumor"]) for pair in plot_df["pair"]] + ax.barh(plot_df["pair"], plot_df["CCI_score"].astype(float), color=bar_colors) + ax.set_xlabel("TopoLink-CCI score") + ax.set_title("Top interpretable axes", fontsize=12, fontweight="bold", loc="left") + ax.set_xlim(0.58, 0.82) + ax.grid(axis="x", color="#e5e7eb") + for idx, (score, rank) in enumerate(zip(plot_df["CCI_score"], plot_df["pyxenium_rank"])): + ax.text(float(score) + 0.004, idx, f"rank {int(rank)}", va="center", fontsize=8) + + # B. VWF-SELP score decomposition. + ax = fig.add_subplot(gs[0, 1]) + add_panel_label(ax, "b") + comp = pd.read_csv(DEEP_DIVE / "tables" / "component_decomposition.tsv", sep="\t") + comp_order = ["sender_anchor", "receiver_anchor", "structure_bridge", "sender_expr", "receiver_expr", "local_contact"] + comp = comp.set_index("component").loc[comp_order].reset_index() + ax.barh(comp["component"].str.replace("_", "\n"), comp["value"].astype(float), color=[COLORS["vascular"]] * 5 + ["#c2410c"]) + ax.set_xlim(0, 1.05) + ax.set_xlabel("component value") + ax.set_title("VWF-SELP is rank 1 by combined support", fontsize=12, fontweight="bold", loc="left") + ax.text(0.05, 0.08, "CCI_score = 0.791\nlocal contact = 0.291\n12,779 endothelial-endothelial edges", transform=ax.transAxes, fontsize=9, bbox=dict(fc="white", ec="#d1d5db", boxstyle="round,pad=0.35")) + ax.grid(axis="x", color="#e5e7eb") + + # C. Existing spatial hotspot overlay. + ax = fig.add_subplot(gs[0, 2]) + add_panel_label(ax, "c") + img_path = DEEP_DIVE / "figures" / "vwf_selp_hotspot_spatial_overlay.png" + img = plt.imread(img_path) + ax.imshow(img) + ax.set_axis_off() + ax.set_title("Endothelial VWF-SELP hotspots in tissue", fontsize=12, fontweight="bold", loc="left") + + # D. Cross-method and validation strength. + ax = fig.add_subplot(gs[1, 0]) + add_panel_label(ax, "d") + metrics = evidence[["pair", "support_count", "cross_method_same_lr_count", "bootstrap_rank_median"]].copy() + metrics = metrics.sort_values("support_count", ascending=True) + y = np.arange(len(metrics)) + ax.barh(y - 0.18, metrics["support_count"], height=0.32, color=COLORS["pass"], label="validation layers") + ax.barh(y + 0.18, metrics["cross_method_same_lr_count"], height=0.32, color=COLORS["blue"], label="same-CCI method support") + ax.set_yticks(y) + ax.set_yticklabels(metrics["pair"], fontsize=9) + ax.set_xlim(0, 9) + ax.set_xlabel("count") + ax.set_title("Support is not single-algorithm self-consistency", fontsize=12, fontweight="bold", loc="left") + ax.legend(frameon=False, fontsize=8, loc="lower right") + ax.grid(axis="x", color="#e5e7eb") + + # E. VWF/SELP expression specificity heatmap. + ax = fig.add_subplot(gs[1, 1]) + add_panel_label(ax, "e") + img_path = DEEP_DIVE / "figures" / "expression_specificity_heatmap.png" + img = plt.imread(img_path) + ax.imshow(img) + ax.set_axis_off() + ax.set_title("WTA expression supports endothelial identity", fontsize=12, fontweight="bold", loc="left") + + # F. Biological model summary. + ax = fig.add_subplot(gs[1, 2]) + ax.set_axis_off() + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + add_panel_label(ax, "f") + ax.set_title("Lead biological interpretation", fontsize=12, fontweight="bold", loc="left") + vessel = patches.FancyBboxPatch((0.12, 0.38), 0.76, 0.2, boxstyle="round,pad=0.04,rounding_size=0.12", fc="#d6f5ef", ec=COLORS["vascular"], lw=2) + ax.add_patch(vessel) + ax.text(0.5, 0.49, "endothelial activation niche", ha="center", va="center", fontsize=12, fontweight="bold", color=COLORS["vascular"]) + ax.text(0.22, 0.68, "VWF", color="#b91c1c", fontsize=16, fontweight="bold") + ax.text(0.67, 0.68, "SELP", color="#b45309", fontsize=16, fontweight="bold") + ax.annotate("", xy=(0.44, 0.58), xytext=(0.28, 0.66), arrowprops=dict(arrowstyle="->", lw=2, color="#b91c1c")) + ax.annotate("", xy=(0.60, 0.58), xytext=(0.69, 0.66), arrowprops=dict(arrowstyle="->", lw=2, color="#b45309")) + rounded_box(ax, (0.08, 0.12), 0.84, 0.17, "Topology-supported molecular interaction axis;\ncomputational validation, not protein-level proof.", fc="#fff7ed", ec="#c2410c", fontsize=10) + ax.text(0.5, 0.88, "Recovered themes: vascular adhesion, ECM/stroma,\nimmune recruitment and Notch signaling", ha="center", fontsize=10) + + fig.suptitle("Figure 2 | Whole-dataset discovery and biological interpretation", fontsize=16, fontweight="bold") + return fig + + +def save_figure(fig: plt.Figure, stem: str) -> None: + OUT.mkdir(parents=True, exist_ok=True) + for ext in ["png", "pdf", "svg"]: + fig.savefig(OUT / f"{stem}.{ext}", dpi=300, bbox_inches="tight") + plt.close(fig) + + +def main() -> None: + evidence = load_evidence() + save_figure(draw_figure_1(evidence), "figure_1_topolink_cci_method_validation") + save_figure(draw_figure_2(evidence), "figure_2_topolink_cci_discovery_biology") + + source = evidence[ + [ + "pair", + "sender", + "receiver", + "biology_label", + "CCI_score", + "pyxenium_rank", + "support_count", + "evidence_class", + "cell_label_perm_fdr", + "spatial_null_fdr", + "matched_gene_z", + "downstream_target_fdr", + "cross_method_same_lr_count", + "bootstrap_rank_median", + ] + ].copy() + source.to_csv(OUT / "figure_source_data.tsv", sep="\t", index=False) + + +if __name__ == "__main__": + main() diff --git a/benchmarking/cci_2026_atera/topolink_cci_short_communication/scripts/make_topolink_cci_panel_library.py b/benchmarking/cci_2026_atera/topolink_cci_short_communication/scripts/make_topolink_cci_panel_library.py new file mode 100644 index 0000000..747240b --- /dev/null +++ b/benchmarking/cci_2026_atera/topolink_cci_short_communication/scripts/make_topolink_cci_panel_library.py @@ -0,0 +1,955 @@ +"""Generate Illustrator-friendly standalone panels for TopoLink-CCI. + +This script is intentionally stricter than an exploratory plotting script: + +- PDF text is exported as editable TrueType/Type 42 text when supported. +- SVG text is kept as rather than converted to paths. +- Every panel is saved through PanelExporter, which requires source data. +- Dense spatial layers are rasterized while axes and labels remain vector. +- A panel manifest records outputs, source hashes, style policy and checks. +""" + +from __future__ import annotations + +import argparse +import datetime as dt +import hashlib +import json +import math +import shutil +import subprocess +from dataclasses import dataclass +from pathlib import Path +from typing import Callable, Iterable + +import matplotlib + +matplotlib.use("Agg") + +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +from matplotlib import font_manager, patches + + +ROOT = Path(__file__).resolve().parents[2] +VALIDATION = ROOT / "pdc_validation_v2_collected" / "topolink_cci_validation_v2" +DEEP_DIVE = ROOT / "vwf_selp_deep_dive" +PDC_PYXENIUM = ROOT / "pdc_collected" / "pdc_20260426_1327" / "runs" / "full_common" / "pyxenium" +OUT_ROOT = ROOT / "topolink_cci_short_communication" / "figures" / "panels" + + +COLORS = { + "vascular": "#0F766E", + "stromal": "#8A5A2B", + "immune": "#3F7F3F", + "notch": "#5B5F97", + "tumor": "#7A7A7A", + "pass": "#138A72", + "weak": "#E69F00", + "risk": "#B23A48", + "blue": "#2563EB", + "gray": "#6B7280", + "light_gray": "#F3F4F6", + "text": "#1F2933", +} + +THEME = { + "VWF-SELP": "vascular", + "VWF-LRP1": "vascular", + "MMRN2-CD93": "vascular", + "CD48-CD2": "immune", + "DLL4-NOTCH3": "notch", + "CXCL12-CXCR4": "stromal", + "JAG1-NOTCH2": "tumor", +} + +SIZE_MM = { + "single": (85, 65), + "wide": (180, 65), + "tall": (85, 110), + "square": (85, 85), +} + +STYLE_POINTS = { + "panel_label": 8, + "title": 7, + "axis_label": 6, + "tick_label": 5, + "legend": 5, + "annotation": 5, + "body": 6, +} + + +def mm_to_inch(value: float) -> float: + return value / 25.4 + + +def file_hash(path: Path) -> str: + if not path.exists(): + return "missing" + h = hashlib.sha256() + with path.open("rb") as fh: + for chunk in iter(lambda: fh.read(1024 * 1024), b""): + h.update(chunk) + return h.hexdigest()[:16] + + +def ensure_bool(series: pd.Series) -> pd.Series: + if series.dtype == bool: + return series + return series.astype(str).str.lower().isin({"true", "1", "yes", "pass"}) + + +@dataclass(frozen=True) +class FigureStyle: + font_family: str + pdf_fonttype: int = 42 + ps_fonttype: int = 42 + svg_fonttype: str = "none" + + @staticmethod + def choose_font() -> str: + installed = {font.name for font in font_manager.fontManager.ttflist} + return "Arial" if "Arial" in installed else "DejaVu Sans" + + @classmethod + def apply(cls) -> "FigureStyle": + font = cls.choose_font() + plt.rcParams.update( + { + "pdf.fonttype": 42, + "ps.fonttype": 42, + "svg.fonttype": "none", + "font.family": font, + "font.sans-serif": [font, "Arial", "DejaVu Sans"], + "font.size": STYLE_POINTS["body"], + "axes.titlesize": STYLE_POINTS["title"], + "axes.labelsize": STYLE_POINTS["axis_label"], + "xtick.labelsize": STYLE_POINTS["tick_label"], + "ytick.labelsize": STYLE_POINTS["tick_label"], + "legend.fontsize": STYLE_POINTS["legend"], + "axes.linewidth": 0.45, + "lines.linewidth": 0.75, + "grid.linewidth": 0.35, + "patch.linewidth": 0.65, + "savefig.dpi": 300, + "figure.dpi": 300, + "text.usetex": False, + } + ) + return cls(font_family=font) + + def as_dict(self) -> dict[str, object]: + return { + "font_family": self.font_family, + "pdf.fonttype": self.pdf_fonttype, + "ps.fonttype": self.ps_fonttype, + "svg.fonttype": self.svg_fonttype, + "panel_label_pt": STYLE_POINTS["panel_label"], + "title_pt": STYLE_POINTS["title"], + "axis_label_pt": STYLE_POINTS["axis_label"], + "tick_label_pt": STYLE_POINTS["tick_label"], + "legend_pt": STYLE_POINTS["legend"], + } + + +class PanelExporter: + def __init__(self, output_root: Path, style: FigureStyle): + self.output_root = output_root + self.style = style + self.manifest_rows: list[dict[str, object]] = [] + for sub in ["pdf", "svg", "png", "source_data", "metadata"]: + (self.output_root / sub).mkdir(parents=True, exist_ok=True) + + def save_panel( + self, + fig: plt.Figure, + panel_id: str, + slug: str, + source_data_df: pd.DataFrame, + metadata: dict[str, object], + ) -> None: + if not isinstance(source_data_df, pd.DataFrame): + raise TypeError(f"{panel_id}_{slug} source_data_df must be a pandas DataFrame") + if source_data_df.empty: + raise ValueError(f"{panel_id}_{slug} source_data_df is empty") + + stem = f"{panel_id}_{slug}" + pdf_path = self.output_root / "pdf" / f"{stem}.pdf" + svg_path = self.output_root / "svg" / f"{stem}.svg" + png_path = self.output_root / "png" / f"{stem}.png" + source_path = self.output_root / "source_data" / f"{stem}.tsv" + metadata_path = self.output_root / "metadata" / f"{stem}.json" + + source_data_df.to_csv(source_path, sep="\t", index=False) + fig.savefig(pdf_path, dpi=300) + fig.savefig(svg_path, dpi=300) + fig.savefig(png_path, dpi=300) + plt.close(fig) + + svg_text_count = 0 + svg_path_count = 0 + if svg_path.exists(): + text = svg_path.read_text(encoding="utf-8", errors="ignore") + svg_text_count = text.count(" Path: + if not self.manifest_rows: + raise RuntimeError("No panels were saved") + manifest = pd.DataFrame(self.manifest_rows) + path = self.output_root / "panel_manifest.tsv" + manifest.to_csv(path, sep="\t", index=False) + return path + + +def make_figure(size_key: str) -> tuple[plt.Figure, plt.Axes]: + width_mm, height_mm = SIZE_MM[size_key] + fig, ax = plt.subplots(figsize=(mm_to_inch(width_mm), mm_to_inch(height_mm)), layout="constrained") + return fig, ax + + +def add_panel_label(ax: plt.Axes, label: str) -> None: + ax.text( + 0.0, + 1.30, + label, + transform=ax.transAxes, + fontsize=STYLE_POINTS["panel_label"], + fontweight="bold", + va="top", + ha="left", + color=COLORS["text"], + ) + + +def clean_axis(ax: plt.Axes, grid_axis: str | None = None) -> None: + ax.spines["top"].set_visible(False) + ax.spines["right"].set_visible(False) + ax.tick_params(length=2, width=0.45) + if grid_axis: + ax.grid(axis=grid_axis, color="#E5E7EB", linewidth=0.35) + + +def rounded_box( + ax: plt.Axes, + x: float, + y: float, + w: float, + h: float, + text: str, + fc: str, + ec: str, + fontsize: float = 5.5, +) -> None: + box = patches.FancyBboxPatch( + (x, y), + w, + h, + boxstyle="round,pad=0.02,rounding_size=0.025", + fc=fc, + ec=ec, + lw=0.7, + ) + ax.add_patch(box) + ax.text(x + w / 2, y + h / 2, text, ha="center", va="center", fontsize=fontsize, color=COLORS["text"]) + + +def load_evidence() -> pd.DataFrame: + path = VALIDATION / "tables" / "topolink_cci_validation_v2_evidence.tsv" + df = pd.read_csv(path, sep="\t") + df["pair"] = df["ligand"] + "-" + df["receptor"] + df["axis_short"] = df["pair"] + "\n" + df["sender"].str.replace(" Cells", "", regex=False) + " -> " + df["receiver"].str.replace(" Cells", "", regex=False) + df["theme"] = df["pair"].map(THEME).fillna("tumor") + for col in [c for c in df.columns if c.endswith("_support")]: + df[col] = ensure_bool(df[col]) + return df.sort_values("pyxenium_rank") + + +def read_scores_for_landscape() -> pd.DataFrame: + path = PDC_PYXENIUM / "pyxenium_scores.tsv" + cols = ["ligand", "receptor", "sender_celltype", "receiver_celltype", "CCI_score"] + df = pd.read_csv(path, sep="\t", usecols=cols) + df["pair"] = df["ligand"] + "-" + df["receptor"] + df["rank"] = df["CCI_score"].rank(ascending=False, method="first").astype(int) + return df + + +def read_full_coords() -> pd.DataFrame: + h5ad_path = PDC_PYXENIUM / "input_cache" / "adata_full_from_sparse_bundle.h5ad" + if not h5ad_path.exists(): + return pd.DataFrame() + import h5py + + with h5py.File(h5ad_path, "r") as h5: + coords = np.asarray(h5["obsm"]["spatial"][:]) + return pd.DataFrame({"x": coords[:, 0], "y": coords[:, 1], "layer": "all_cells"}) + + +def source_meta(title: str, source_tables: Iterable[Path], message: str, caveat: str = "", rasterized: bool = False) -> dict[str, object]: + return { + "title": title, + "source_tables": [str(p) for p in source_tables], + "rasterized_layers": rasterized, + "biological_message": message, + "caveat": caveat, + "output_formats": ["pdf", "svg", "png"], + } + + +def fig1a_problem_schematic() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("wide") + ax.set_axis_off() + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + add_panel_label(ax, "Fig. 1a") + ax.text(0.02, 0.92, "False-positive problem in spatial CCI", fontsize=STYLE_POINTS["title"], fontweight="bold") + + rounded_box(ax, 0.06, 0.57, 0.22, 0.2, "expression-only\ncandidate", "#FEF3C7", COLORS["weak"]) + rounded_box(ax, 0.37, 0.57, 0.22, 0.2, "database\nmembership", "#FEE2E2", COLORS["risk"]) + rounded_box(ax, 0.68, 0.57, 0.22, 0.2, "spatial\nproximity", "#DBEAFE", COLORS["blue"]) + ax.annotate("", xy=(0.34, 0.67), xytext=(0.28, 0.67), arrowprops=dict(arrowstyle="->", lw=0.8)) + ax.annotate("", xy=(0.65, 0.67), xytext=(0.59, 0.67), arrowprops=dict(arrowstyle="->", lw=0.8)) + ax.text(0.5, 0.43, "Any one layer alone can be misleading", ha="center", fontsize=STYLE_POINTS["body"], color=COLORS["gray"]) + rounded_box(ax, 0.18, 0.14, 0.64, 0.18, "TopoLink-CCI requires concordant topology + expression + local contact,\nthen tests candidates with orthogonal controls.", "#ECFDF5", COLORS["pass"]) + + source = pd.DataFrame( + [ + {"element": "box", "x": 0.17, "y": 0.67, "label": "expression-only candidate", "category": "false_positive_source", "value": 1}, + {"element": "box", "x": 0.48, "y": 0.67, "label": "database membership", "category": "false_positive_source", "value": 1}, + {"element": "box", "x": 0.79, "y": 0.67, "label": "spatial proximity", "category": "false_positive_source", "value": 1}, + {"element": "box", "x": 0.5, "y": 0.23, "label": "TopoLink-CCI combined evidence", "category": "solution", "value": 1}, + ] + ) + return fig, source, source_meta( + "False-positive problem in spatial CCI", + [], + "Spatial CCI needs orthogonal evidence beyond expression, database membership or proximity alone.", + "Schematic panel; source data records graphical elements.", + ) + + +def fig1b_topolink_score_formula() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("wide") + ax.set_axis_off() + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + add_panel_label(ax, "Fig. 1b") + ax.text(0.02, 0.92, "TopoLink-CCI discovery score", fontsize=STYLE_POINTS["title"], fontweight="bold") + ax.text( + 0.5, + 0.72, + "TopoLink-CCI(l,r,s,t) = prior(l,r) x geometric mean( six evidence components )", + ha="center", + fontsize=7, + color=COLORS["text"], + ) + components = [ + ("sender anchor", "ligand fits sender topology", COLORS["vascular"]), + ("receiver anchor", "receptor fits receiver topology", COLORS["notch"]), + ("structure bridge", "sender-receiver tissue relation", COLORS["blue"]), + ("sender expression", "ligand expressed in sender", "#2F855A"), + ("receiver expression", "receptor expressed in receiver", "#2F855A"), + ("local contact", "neighbor edges support interaction", "#C2410C"), + ] + xs = [0.06, 0.37, 0.68, 0.06, 0.37, 0.68] + ys = [0.45, 0.45, 0.45, 0.18, 0.18, 0.18] + rows = [] + for i, (name, desc, color) in enumerate(components): + rounded_box(ax, xs[i], ys[i], 0.25, 0.16, f"{name}\n{desc}", "#FFFFFF", color, fontsize=5.4) + rows.append({"element": "component", "x": xs[i] + 0.125, "y": ys[i] + 0.08, "label": name, "category": "score_component", "description": desc, "value": i + 1}) + return fig, pd.DataFrame(rows), source_meta( + "TopoLink-CCI score formula", + [], + "The discovery score is a prior-weighted geometric mean of six diagnostic components.", + "Schematic formula uses editable text rather than math outlines.", + ) + + +def fig1c_local_contact_model() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("single") + ax.set_axis_off() + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + add_panel_label(ax, "Fig. 1c") + ax.text(0.04, 0.92, "Local contact support", fontsize=STYLE_POINTS["title"], fontweight="bold") + senders = [(0.25, 0.68), (0.20, 0.48), (0.32, 0.32)] + receivers = [(0.68, 0.70), (0.76, 0.50), (0.62, 0.34)] + rows = [] + for i, (x, y) in enumerate(senders): + ax.scatter(x, y, s=80, color=COLORS["vascular"], edgecolor="white", linewidth=0.4, zorder=3) + rows.append({"element": "node", "x": x, "y": y, "label": f"sender_{i+1}", "category": "sender", "value": 1}) + for i, (x, y) in enumerate(receivers): + ax.scatter(x, y, s=80, color=COLORS["notch"], edgecolor="white", linewidth=0.4, zorder=3) + rows.append({"element": "node", "x": x, "y": y, "label": f"receiver_{i+1}", "category": "receiver", "value": 1}) + edges = [(senders[0], receivers[0], 0.9), (senders[0], receivers[1], 0.5), (senders[1], receivers[1], 0.7), (senders[2], receivers[2], 0.8), (senders[1], receivers[2], 0.2)] + for i, (a, b, strength) in enumerate(edges): + ax.plot([a[0], b[0]], [a[1], b[1]], color="#374151", alpha=0.25 + strength * 0.55, lw=0.4 + strength * 1.2, zorder=1) + rows.append({"element": "edge", "x": (a[0]+b[0])/2, "y": (a[1]+b[1])/2, "label": f"edge_{i+1}", "category": "neighbor_edge", "value": strength}) + rounded_box(ax, 0.08, 0.06, 0.84, 0.16, "local contact = f(edge strength, active-edge coverage, edge-count support)", "#F9FAFB", COLORS["gray"], fontsize=5.1) + rows.append({"element": "formula", "x": 0.5, "y": 0.14, "label": "local contact support", "category": "summary", "value": 1}) + return fig, pd.DataFrame(rows), source_meta( + "Local contact model", + [], + "Local contact links candidate molecular axes to the actual cell-cell neighbor graph.", + "Schematic panel; source data records nodes and edges.", + ) + + +def fig1d_validation_gate_map() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("wide") + ax.set_axis_off() + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + add_panel_label(ax, "Fig. 1d") + ax.text(0.02, 0.92, "Orthogonal validation gates adapted from CCC methods", fontsize=STYLE_POINTS["title"], fontweight="bold") + gates = [ + ("CellPhoneDB/\nSquidpy", "cell-label\npermutation", COLORS["blue"]), + ("CellChat", "group\nspecificity", COLORS["notch"]), + ("stLearn/\nSpatialDM", "spatial null +\nmatched genes", COLORS["vascular"]), + ("NicheNet", "receiver target\nsupport", COLORS["immune"]), + ("LIANA", "cross-method\nconsensus", COLORS["stromal"]), + ("pyXenium", "ablation +\nbootstrap", COLORS["pass"]), + ] + rows = [] + for i, (method, gate, color) in enumerate(gates): + x = 0.04 + i * 0.155 + rounded_box(ax, x, 0.52, 0.13, 0.18, method, "#FFFFFF", color) + ax.annotate("", xy=(x + 0.065, 0.42), xytext=(x + 0.065, 0.52), arrowprops=dict(arrowstyle="->", lw=0.7, color=COLORS["text"])) + rounded_box(ax, x, 0.22, 0.13, 0.16, gate, "#F9FAFB", color) + rows.append({"element": "gate", "x": x + 0.065, "y": 0.3, "label": gate.replace("\n", " "), "category": method.replace("\n", " "), "value": i + 1}) + return fig, pd.DataFrame(rows), source_meta( + "Validation gate map", + [], + "TopoLink-CCI reports candidates with controls inspired by established CCC methods.", + "Schematic mapping, not a claim of identical software reimplementation.", + ) + + +def fig1e_evidence_matrix(evidence: pd.DataFrame) -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("wide") + add_panel_label(ax, "Fig. 1e") + layers = [ + ("expression", "expression_specificity_support"), + ("label perm.", "cell_label_permutation_support"), + ("spatial null", "spatial_null_support"), + ("matched genes", "matched_gene_control_support"), + ("downstream", "downstream_target_support"), + ("received signal", "functional_received_signal_support"), + ("cross method", "cross_method_support"), + ("ablation", "component_ablation_support"), + ("bootstrap", "bootstrap_stability_support"), + ] + pairs = evidence["pair"].tolist() + source_rows = [] + for i, pair in enumerate(pairs): + for j, (label, col) in enumerate(layers): + passed = bool(evidence.iloc[i][col]) + ax.scatter(j, i, s=50, marker="o" if passed else "X", color=COLORS["pass"] if passed else COLORS["weak"], edgecolor="white", linewidth=0.35) + source_rows.append({"x": label, "y": pair, "value": int(passed), "category": "pass" if passed else "weak", "label": f"{pair}:{label}"}) + ax.set_xticks(range(len(layers))) + ax.set_xticklabels([x for x, _ in layers], rotation=35, ha="right") + ax.set_yticks(range(len(pairs))) + ax.set_yticklabels(pairs) + ax.set_xlim(-0.5, len(layers) - 0.5) + ax.set_ylim(len(pairs) - 0.5, -0.5) + ax.set_title("Evidence matrix for representative axes", loc="left", fontsize=STYLE_POINTS["title"]) + ax.grid(color="#E5E7EB", linewidth=0.35) + ax.tick_params(length=0) + return fig, pd.DataFrame(source_rows), source_meta( + "Evidence matrix", + [VALIDATION / "tables" / "topolink_cci_validation_v2_evidence.tsv"], + "Seven representative TopoLink-CCI axes have strong computational support.", + "Orange marks are axis-specific weak evidence layers, not artifact-risk calls.", + ) + + +def fig1f_false_positive_controls_quantitative(evidence: pd.DataFrame) -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("wide") + add_panel_label(ax, "Fig. 1f") + metric_defs = [ + ("label perm. FDR", "cell_label_perm_fdr", "-log10"), + ("spatial null FDR", "spatial_null_fdr", "-log10"), + ("matched gene z", "matched_gene_z", "z"), + ("downstream FDR", "downstream_target_fdr", "-log10"), + ] + rows = [] + for i, row in evidence.iterrows(): + pair = row["pair"] + for j, (label, col, transform) in enumerate(metric_defs): + raw = float(row[col]) + value = -math.log10(max(raw, 1e-300)) if transform == "-log10" else raw + rows.append({"x": label, "y": pair, "value": value, "raw_value": raw, "category": transform, "label": pair}) + src = pd.DataFrame(rows) + pairs = evidence["pair"].tolist() + for _, row in src.iterrows(): + x = [m[0] for m in metric_defs].index(row["x"]) + y = pairs.index(row["y"]) + size = 10 + min(float(row["value"]), 12) * 8 + ax.scatter(x, y, s=size, color=COLORS["pass"], alpha=0.85, edgecolor="white", linewidth=0.25) + ax.set_xticks(range(len(metric_defs))) + ax.set_xticklabels([m[0] for m in metric_defs], rotation=25, ha="right") + ax.set_yticks(range(len(pairs))) + ax.set_yticklabels(pairs) + ax.set_ylim(len(pairs) - 0.5, -0.5) + ax.set_title("Quantitative false-positive controls", loc="left", fontsize=STYLE_POINTS["title"]) + ax.grid(color="#E5E7EB", linewidth=0.35) + ax.tick_params(length=0) + return fig, src, source_meta( + "Quantitative false-positive controls", + [VALIDATION / "tables" / "topolink_cci_validation_v2_evidence.tsv"], + "Representative axes pass multiple quantitative controls, not just the TopoLink-CCI score.", + "Bubble sizes use transformed metrics; raw values are in source data.", + ) + + +def fig2a_whole_dataset_rank_landscape(evidence: pd.DataFrame) -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("wide") + add_panel_label(ax, "Fig. 2a") + scores = read_scores_for_landscape() + bins = np.linspace(0, scores["CCI_score"].max(), 120) + counts, edges = np.histogram(scores["CCI_score"], bins=bins) + centers = (edges[:-1] + edges[1:]) / 2 + ax.fill_between(centers, counts, color="#CBD5E1", step="mid") + ax.set_yscale("log") + ax.set_xlabel("TopoLink-CCI score") + ax.set_ylabel("candidate axes") + ax.set_title("Whole-dataset score landscape", loc="left", fontsize=STYLE_POINTS["title"]) + clean_axis(ax, "y") + highlight_rows = [] + for _, row in evidence.iterrows(): + score = float(row["CCI_score"]) + pair = row["pair"] + color = COLORS[THEME.get(pair, "tumor")] + ax.axvline(score, color=color, lw=0.9, alpha=0.85) + highlight_rows.append({"x": score, "y": np.nan, "value": int(row["pyxenium_rank"]), "category": row["theme"], "label": pair}) + hist_src = pd.DataFrame({"x": centers, "y": counts, "value": counts, "category": "histogram", "label": "CCI_score_bin"}) + src = pd.concat([hist_src, pd.DataFrame(highlight_rows)], ignore_index=True) + return fig, src, source_meta( + "Whole-dataset score landscape", + [PDC_PYXENIUM / "pyxenium_scores.tsv", VALIDATION / "tables" / "topolink_cci_validation_v2_evidence.tsv"], + "TopoLink-CCI ranks 1,319,600 whole-dataset candidate axes and highlights validated discoveries.", + "Histogram bins are source data; highlighted lines mark seven representative axes.", + ) + + +def fig2b_top_interpretable_axes(evidence: pd.DataFrame) -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("single") + add_panel_label(ax, "Fig. 2b") + plot = evidence.sort_values("CCI_score", ascending=True) + colors = [COLORS[THEME.get(pair, "tumor")] for pair in plot["pair"]] + y = np.arange(len(plot)) + ax.barh(y, plot["CCI_score"], color=colors, height=0.65) + ax.set_yticks(y) + ax.set_yticklabels(plot["pair"]) + ax.set_xlabel("TopoLink-CCI score") + ax.set_xlim(0.60, 0.82) + clean_axis(ax, "x") + ax.set_title("Top interpretable axes", loc="left", fontsize=STYLE_POINTS["title"]) + for idx, row in enumerate(plot.itertuples()): + ax.text(float(row.CCI_score) + 0.004, idx, f"r{int(row.pyxenium_rank)}", va="center", fontsize=STYLE_POINTS["tick_label"]) + src = plot[["pair", "sender", "receiver", "CCI_score", "pyxenium_rank", "biology_label", "theme"]].rename(columns={"CCI_score": "x", "pyxenium_rank": "value"}) + src["y"] = src["pair"] + src["category"] = src["theme"] + src["label"] = src["pair"] + return fig, src, source_meta( + "Top interpretable axes", + [VALIDATION / "tables" / "topolink_cci_validation_v2_evidence.tsv"], + "High-scoring axes span vascular, immune, stromal, Notch and tumor-intrinsic biology.", + ) + + +def fig2c_vwf_selp_component_decomposition() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("single") + add_panel_label(ax, "Fig. 2c") + path = DEEP_DIVE / "tables" / "component_decomposition.tsv" + comp = pd.read_csv(path, sep="\t") + order = ["sender_anchor", "receiver_anchor", "structure_bridge", "sender_expr", "receiver_expr", "local_contact"] + comp = comp.set_index("component").loc[order].reset_index() + y = np.arange(len(comp)) + colors = [COLORS["vascular"]] * 5 + ["#C2410C"] + ax.barh(y, comp["value"], color=colors, height=0.62) + ax.set_yticks(y) + ax.set_yticklabels(comp["component"].str.replace("_", " ")) + ax.set_xlim(0, 1.05) + ax.set_xlabel("component value") + clean_axis(ax, "x") + ax.set_title("VWF-SELP component support", loc="left", fontsize=STYLE_POINTS["title"]) + ax.text(0.04, 0.05, "score 0.791\n12,779 local edges", transform=ax.transAxes, fontsize=STYLE_POINTS["annotation"], bbox=dict(fc="white", ec="#D1D5DB", lw=0.5)) + src = comp.rename(columns={"component": "label", "value": "x"}) + src["y"] = src["label"] + src["value"] = src["x"] + src["category"] = ["component"] * len(src) + return fig, src, source_meta( + "VWF-SELP component decomposition", + [path], + "The lead endothelial axis combines topology, expression and local contact support.", + ) + + +def fig2d_vwf_selp_rank_sensitivity() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("single") + add_panel_label(ax, "Fig. 2d") + path = DEEP_DIVE / "tables" / "rank_sensitivity.tsv" + data = pd.read_csv(path, sep="\t").head(10) + y = np.arange(len(data))[::-1] + ax.scatter(data["target_rank"], y, color=COLORS["vascular"], s=28, zorder=3) + ax.plot(data["target_rank"], y, color=COLORS["vascular"], lw=0.7) + ax.set_yticks(y) + ax.set_yticklabels(data["scenario"].str.replace("_", " ")) + ax.set_xlabel("VWF-SELP rank") + ax.set_xlim(0.5, max(3, data["target_rank"].max() + 1)) + ax.set_title("Rank sensitivity", loc="left", fontsize=STYLE_POINTS["title"]) + clean_axis(ax, "x") + src = data.copy() + src["x"] = src["target_rank"] + src["y"] = src["scenario"] + src["value"] = src["target_score"] + src["category"] = "rank_sensitivity" + src["label"] = src["scenario"] + return fig, src, source_meta( + "VWF-SELP rank sensitivity", + [path], + "Component perturbations test whether the top axis is driven by one isolated term.", + ) + + +def fig2e_expression_specificity_dotplot() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("wide") + add_panel_label(ax, "Fig. 2e") + path = DEEP_DIVE / "tables" / "expression_specificity_full_wta.tsv" + df = pd.read_csv(path, sep="\t") + genes = ["VWF", "SELP", "PECAM1", "EMCN", "KDR", "FLT1", "MMRN2", "CLEC14A", "PPBP", "PF4", "ITGA2B", "GP1BA", "HBB"] + plot = df[df["gene"].isin(genes)].copy() + cell_order = plot.groupby("cell_type")["mean_log1p_norm_by_gene"].max().sort_values(ascending=False).index.tolist() + gene_order = genes + x_map = {c: i for i, c in enumerate(cell_order)} + y_map = {g: i for i, g in enumerate(gene_order)} + plot["x"] = plot["cell_type"].map(x_map) + plot["y"] = plot["gene"].map(y_map) + sizes = 5 + 45 * plot["detection_fraction"].clip(0, 1) + sc = ax.scatter(plot["x"], plot["y"], s=sizes, c=plot["mean_log1p_norm_by_gene"], cmap="viridis", vmin=0, vmax=1, edgecolor="none") + ax.set_xticks(range(len(cell_order))) + ax.set_xticklabels(cell_order, rotation=55, ha="right") + ax.set_yticks(range(len(gene_order))) + ax.set_yticklabels(gene_order) + ax.set_title("Expression specificity and contamination controls", loc="left", fontsize=STYLE_POINTS["title"]) + ax.tick_params(length=0) + ax.grid(color="#F3F4F6", linewidth=0.35) + cbar = fig.colorbar(sc, ax=ax, fraction=0.018, pad=0.01) + cbar.set_label("gene-normalized expression", fontsize=STYLE_POINTS["axis_label"]) + cbar.ax.tick_params(labelsize=STYLE_POINTS["tick_label"], length=2) + plot["value"] = plot["mean_log1p_norm_by_gene"] + plot["category"] = np.where(plot["gene"].isin(["PPBP", "PF4", "ITGA2B", "GP1BA", "HBB"]), "contamination_control", "endothelial_or_axis_marker") + plot["label"] = plot["gene"] + "|" + plot["cell_type"] + return fig, plot, source_meta( + "Expression specificity dotplot", + [path], + "VWF-SELP interpretation is supported by endothelial marker specificity and contamination controls.", + "RNA expression specificity does not prove protein localization.", + ) + + +def fig2f_vwf_selp_spatial_hotspots() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("square") + add_panel_label(ax, "Fig. 2f") + hotspot_path = DEEP_DIVE / "tables" / "vwf_selp_hotspot_endothelial_cells.tsv" + hotspots = pd.read_csv(hotspot_path, sep="\t") + coords = read_full_coords() + rasterized = False + rows = [] + if not coords.empty: + rasterized = True + ax.scatter(coords["x"], coords["y"], s=0.08, color="#94A3B8", alpha=0.22, linewidths=0, rasterized=True) + rows.append(coords.assign(value=np.nan, category="background", label="all_cells")[["x", "y", "value", "category", "label"]]) + sc = ax.scatter( + hotspots["x"], + hotspots["y"], + c=hotspots["hotspot_score"], + cmap="magma", + vmin=0, + vmax=1, + s=5, + edgecolor="none", + rasterized=len(hotspots) > 5000, + ) + rows.append(hotspots.assign(value=hotspots["hotspot_score"], category="hotspot", label=hotspots["cell_id"])[["x", "y", "value", "category", "label"]]) + ax.set_aspect("equal") + ax.invert_yaxis() + ax.set_xlabel("x (um)") + ax.set_ylabel("y (um)") + ax.set_title("VWF-SELP endothelial hotspots", loc="left", fontsize=STYLE_POINTS["title"]) + clean_axis(ax) + cbar = fig.colorbar(sc, ax=ax, fraction=0.035, pad=0.02) + cbar.set_label("hotspot score", fontsize=STYLE_POINTS["axis_label"]) + cbar.ax.tick_params(labelsize=STYLE_POINTS["tick_label"], length=2) + src = pd.concat(rows, ignore_index=True) + return fig, src, source_meta( + "VWF-SELP spatial hotspots", + [hotspot_path, PDC_PYXENIUM / "input_cache" / "adata_full_from_sparse_bundle.h5ad"], + "VWF-SELP hotspots localize to a subset of endothelial neighborhoods.", + "Dense background cells are rasterized to keep Illustrator files usable.", + rasterized=rasterized, + ) + + +def fig2g_hotspot_neighborhood_context() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("single") + add_panel_label(ax, "Fig. 2g") + path = DEEP_DIVE / "tables" / "hotspot_neighbor_context.tsv" + data = pd.read_csv(path, sep="\t").sort_values("neighbor_fraction", ascending=True) + y = np.arange(len(data)) + ax.barh(y, data["neighbor_fraction"], color=COLORS["vascular"], height=0.62) + ax.set_yticks(y) + ax.set_yticklabels(data["neighbor_cell_type"].str.replace(" Cells", "")) + ax.set_xlabel("neighbor fraction") + ax.set_title("Hotspot neighborhood context", loc="left", fontsize=STYLE_POINTS["title"]) + clean_axis(ax, "x") + data["x"] = data["neighbor_fraction"] + data["y"] = data["neighbor_cell_type"] + data["value"] = data["neighbor_fraction"] + data["category"] = data["group"] + data["label"] = data["neighbor_cell_type"] + return fig, data, source_meta( + "Hotspot neighborhood context", + [path], + "Endothelial VWF-SELP hotspots can be interpreted through their neighboring cell ecology.", + ) + + +def fig2h_pathway_context() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("single") + add_panel_label(ax, "Fig. 2h") + path = DEEP_DIVE / "tables" / "vwf_selp_pathway_correlations.tsv" + data = pd.read_csv(path, sep="\t").sort_values("spearman_rho_vs_vwf_selp_joint", ascending=True) + y = np.arange(len(data)) + ax.barh(y, data["spearman_rho_vs_vwf_selp_joint"], color=COLORS["vascular"], height=0.6) + ax.set_yticks(y) + ax.set_yticklabels(data["pathway"].str.replace("_", "\n")) + ax.set_xlabel("Spearman rho") + ax.set_title("Pathway context", loc="left", fontsize=STYLE_POINTS["title"]) + clean_axis(ax, "x") + data["x"] = data["spearman_rho_vs_vwf_selp_joint"] + data["y"] = data["pathway"] + data["value"] = data["spearman_rho_vs_vwf_selp_joint"] + data["category"] = "pathway_correlation" + data["label"] = data["pathway"] + return fig, data, source_meta( + "Pathway context", + [path], + "VWF-SELP hotspots align with vascular identity and thromboinflammatory pathway panels.", + "Pathway panels are RNA-level summaries.", + ) + + +def fig2i_contour_ecology_context() -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("single") + add_panel_label(ax, "Fig. 2i") + path = DEEP_DIVE / "tables" / "contour_hypothesis_ranking.tsv" + data = pd.read_csv(path, sep="\t").sort_values("mean_score", ascending=True) + colors = [COLORS["vascular"] if "vascular" in p else COLORS["gray"] for p in data["program"]] + y = np.arange(len(data)) + ax.barh(y, data["mean_score"], color=colors, height=0.62) + ax.axvline(0, color="#111827", lw=0.45) + ax.set_yticks(y) + ax.set_yticklabels(data["program"].str.replace("_", "\n")) + ax.set_xlabel("mean contour score") + ax.set_title("Contour ecology context", loc="left", fontsize=STYLE_POINTS["title"]) + clean_axis(ax, "x") + data["x"] = data["mean_score"] + data["y"] = data["program"] + data["value"] = data["mean_score"] + data["category"] = np.where(data["program"].str.contains("vascular"), "vascular_contour", "other_contour") + data["label"] = data["program"] + return fig, data, source_meta( + "Contour ecology context", + [path], + "Vascular interaction axes can be interpreted in the broader contour and tissue-ecology context.", + ) + + +def fig2j_cross_method_consensus(evidence: pd.DataFrame) -> tuple[plt.Figure, pd.DataFrame, dict[str, object]]: + fig, ax = make_figure("wide") + add_panel_label(ax, "Fig. 2j") + path = VALIDATION / "tables" / "cross_method_support_detail.tsv" + data = pd.read_csv(path, sep="\t") + data["pair"] = data["axis_id"].str.split("|", regex=False).str[0] + methods = sorted(data["method"].unique()) + pairs = evidence["pair"].tolist() + x_map = {m: i for i, m in enumerate(methods)} + y_map = {p: i for i, p in enumerate(pairs)} + data["exact_support"] = ensure_bool(data["exact_support"]) + data["same_lr_any_celltype_support"] = ensure_bool(data["same_lr_any_celltype_support"]) + data["support_level"] = np.where(data["exact_support"], 2, np.where(data["same_lr_any_celltype_support"], 1, 0)) + for _, row in data.iterrows(): + if row["pair"] not in y_map: + continue + marker = "s" if row["support_level"] == 2 else "o" if row["support_level"] == 1 else "x" + color = COLORS["pass"] if row["support_level"] == 2 else COLORS["blue"] if row["support_level"] == 1 else "#D1D5DB" + ax.scatter(x_map[row["method"]], y_map[row["pair"]], s=45, marker=marker, color=color, edgecolor="white", linewidth=0.35) + ax.set_xticks(range(len(methods))) + ax.set_xticklabels(methods, rotation=35, ha="right") + ax.set_yticks(range(len(pairs))) + ax.set_yticklabels(pairs) + ax.set_ylim(len(pairs) - 0.5, -0.5) + ax.set_title("Cross-method consensus", loc="left", fontsize=STYLE_POINTS["title"]) + ax.grid(color="#E5E7EB", linewidth=0.35) + ax.tick_params(length=0) + data["x"] = data["method"] + data["y"] = data["pair"] + data["value"] = data["support_level"] + data["category"] = np.where(data["support_level"] == 2, "exact", np.where(data["support_level"] == 1, "same_lr", "none")) + data["label"] = data["axis_id"] + "|" + data["method"] + return fig, data, source_meta( + "Cross-method consensus", + [path], + "TopoLink-CCI discoveries are triangulated against independent method outputs.", + "Methods differ in score definitions; this panel shows support categories, not raw score equivalence.", + ) + + +PanelFunc = Callable[..., tuple[plt.Figure, pd.DataFrame, dict[str, object]]] + + +def build_registry(evidence: pd.DataFrame) -> dict[str, tuple[str, str, Callable[[], tuple[plt.Figure, pd.DataFrame, dict[str, object]]]]]: + return { + "fig1a": ("fig1a", "problem_schematic", fig1a_problem_schematic), + "fig1b": ("fig1b", "topolink_score_formula", fig1b_topolink_score_formula), + "fig1c": ("fig1c", "local_contact_model", fig1c_local_contact_model), + "fig1d": ("fig1d", "validation_gate_map", fig1d_validation_gate_map), + "fig1e": ("fig1e", "evidence_matrix", lambda: fig1e_evidence_matrix(evidence)), + "fig1f": ("fig1f", "false_positive_controls_quantitative", lambda: fig1f_false_positive_controls_quantitative(evidence)), + "fig2a": ("fig2a", "whole_dataset_rank_landscape", lambda: fig2a_whole_dataset_rank_landscape(evidence)), + "fig2b": ("fig2b", "top_interpretable_axes", lambda: fig2b_top_interpretable_axes(evidence)), + "fig2c": ("fig2c", "vwf_selp_component_decomposition", fig2c_vwf_selp_component_decomposition), + "fig2d": ("fig2d", "vwf_selp_rank_sensitivity", fig2d_vwf_selp_rank_sensitivity), + "fig2e": ("fig2e", "expression_specificity_dotplot", fig2e_expression_specificity_dotplot), + "fig2f": ("fig2f", "vwf_selp_spatial_hotspots", fig2f_vwf_selp_spatial_hotspots), + "fig2g": ("fig2g", "hotspot_neighborhood_context", fig2g_hotspot_neighborhood_context), + "fig2h": ("fig2h", "pathway_context", fig2h_pathway_context), + "fig2i": ("fig2i", "contour_ecology_context", fig2i_contour_ecology_context), + "fig2j": ("fig2j", "cross_method_consensus", lambda: fig2j_cross_method_consensus(evidence)), + } + + +def run_quality_checks(output_root: Path, expected_panels: int) -> None: + pdf_n = len(list((output_root / "pdf").glob("*.pdf"))) + svg_n = len(list((output_root / "svg").glob("*.svg"))) + png_n = len(list((output_root / "png").glob("*.png"))) + src_n = len(list((output_root / "source_data").glob("*.tsv"))) + meta_n = len(list((output_root / "metadata").glob("*.json"))) + if len({pdf_n, svg_n, png_n, src_n, meta_n, expected_panels}) != 1: + raise RuntimeError( + f"Panel output count mismatch: pdf={pdf_n}, svg={svg_n}, png={png_n}, " + f"source={src_n}, metadata={meta_n}, expected={expected_panels}" + ) + manifest = pd.read_csv(output_root / "panel_manifest.tsv", sep="\t") + if len(manifest) != expected_panels: + raise RuntimeError(f"Manifest has {len(manifest)} rows, expected {expected_panels}") + fig2f = manifest[manifest["panel_id"] == "fig2f"] + if fig2f.empty or not bool(fig2f.iloc[0]["rasterized_layers"]): + raise RuntimeError("fig2f must be marked as rasterized_layers=true") + if (manifest["svg_text_count"] <= 0).any(): + bad = manifest.loc[manifest["svg_text_count"] <= 0, "panel_id"].tolist() + raise RuntimeError(f"SVG text was not retained for panels: {bad}") + + +def main() -> None: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--panel", action="append", help="Panel id to render, e.g. fig1a. Repeatable. Default: all panels.") + parser.add_argument("--all", action="store_true", help="Render all panels. This is the default when --panel is omitted.") + args = parser.parse_args() + + style = FigureStyle.apply() + evidence = load_evidence() + registry = build_registry(evidence) + selected = args.panel or list(registry.keys()) + unknown = [panel for panel in selected if panel not in registry] + if unknown: + raise ValueError(f"Unknown panel ids: {unknown}. Available: {sorted(registry)}") + + exporter = PanelExporter(OUT_ROOT, style) + for key in selected: + panel_id, slug, fn = registry[key] + fig, source, metadata = fn() + exporter.save_panel(fig, panel_id, slug, source, metadata) + exporter.write_manifest() + if len(selected) == len(registry): + run_quality_checks(OUT_ROOT, expected_panels=len(registry)) + + +if __name__ == "__main__": + main() diff --git a/benchmarking/cci_2026_atera/vwf_selp_deep_dive/figures/component_decomposition.png b/benchmarking/cci_2026_atera/vwf_selp_deep_dive/figures/component_decomposition.png new file mode 100644 index 0000000000000000000000000000000000000000..c7c4ce52fbe00dfc585d80fd3d6be128e2c1ed8a GIT binary patch literal 70440 zcmd?RS5(y5w=Ikj+5lnzB&xIl5DM6!zHEV+n^h=PFKl0iVBK(dlk0V+Ys zP(Tq21PMiySmgTFF1pY8fA>D!m-BG1V|2@q3j4RiT64}d*M4#BHF0!#_{5k-`Jtnom93+d`J)rg#!no~ zZEb`Fgf0k(pFd&d=xFC4DJW?DU#}3bePSx8^qE@&KIIR)TiOmZG@M`2e>-eioMdTs z(9qnzenrDIcB-E?G_+$??zdv@o$H?;$R9lSq2}2GE4d67Bk_WB%S?O)W>xnOi!NWa 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figure titled: + +**pyXenium identifies a topology-supported endothelial VWF-SELP vascular activation niche** + +Canvas: 16:9 landscape, clean manuscript style, white/off-white background, teal endothelial palette with crimson VWF and amber SELP/P-selectin highlights. + +## Required panel narrative + +1. **A. Biological model**: draw an endothelial vessel neighborhood with VWF strings, SELP/P-selectin on activated endothelial surfaces, nearby T cell/immune rolling, and pericyte context. Include caveat: RNA/spatial evidence, not direct protein release proof. +2. **B. pyXenium evidence stack**: show CCI_score 0.791, rank 1, component values, and the rank-sensitivity callout: removing local contact drops VWF-SELP to rank 13. +3. **C. WTA specificity**: show VWF and SELP enriched in endothelial cells with endothelial markers PECAM1, EMCN, KDR, MMRN2, CLEC14A. Include HBB/PF4 contamination control note. +4. **D. Spatial hotspot map**: use the hotspot spatial overlay and show 433 endothelial hotspot cells; add small bar chart for T cell/pericyte-associated neighborhoods. +5. **E. Tissue ecology and cross-method support**: show S3 vascular contour enrichment and exact VWF-SELP recovery by CellPhoneDB and LARIS. + +Use the generated local output `vwf_selp_endothelial_activation_main_figure.svg` or PDF as the editable source if importing into Canva. For a talk-style Canva page, use `vwf_selp_endothelial_activation_conference_summary.png` or PDF. diff --git a/benchmarking/cci_2026_atera/vwf_selp_deep_dive/figures/final/figure_caption.md b/benchmarking/cci_2026_atera/vwf_selp_deep_dive/figures/final/figure_caption.md new file mode 100644 index 0000000..a4811aa --- /dev/null +++ b/benchmarking/cci_2026_atera/vwf_selp_deep_dive/figures/final/figure_caption.md @@ -0,0 +1,6 @@ +# Figure caption + +**pyXenium identifies a topology-supported endothelial VWF-SELP vascular activation niche.** +The whole-dataset Xenium WTA breast benchmark ranked `VWF-SELP / Endothelial Cells -> Endothelial Cells` as the strongest pyXenium ligand-receptor axis (`CCI_score=0.791`). The component stack shows high sender and receiver topology anchors, full expression support, a perfect structure bridge, and a local endothelial contact score of `0.291`; removing the local-contact term drops the interaction from rank 1 to rank 13. Full WTA expression summaries show that `VWF` and `SELP` are most enriched in endothelial cells, alongside canonical endothelial markers including `PECAM1`, `EMCN`, `KDR`, `MMRN2`, and `CLEC14A`, while blood/platelet contamination controls remain secondary. Spatial hotspot analysis identifies 433 high-scoring endothelial cells with T-cell and pericyte-enriched neighborhood context. S1-S5 contour analysis places vascular markers in S3-enriched tissue regions, and CellPhoneDB/LARIS independently recover exact `VWF-SELP` endothelial-endothelial support. Together, the data support an endothelial activation / Weibel-Palade body-associated adhesion state. This is RNA-level and spatial-topology evidence, not direct proof of VWF/P-selectin protein release or thrombosis. + +Literature context: Weibel-Palade bodies are endothelial storage organelles containing VWF and P-selectin and connect vascular adhesion, hemostasis, and inflammation. 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